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Profile

Jindan Yu

  • Department of Urology
    Professor
  • J. Yu Lab
Head shot of Jindan Yu

Overview

Dr. Jindan Yu is the Fray F. Marshall Chair in Biomedical Urologic Research at Emory University School of Medicine. She is a Professor and Vice Chair for Research in the Department of Urology, spearheading the discoveries of novel biomarkers and therapeutic approaches for aggressive prostate and genitourinary cancers. Dr. Yu also serves as the Scientific Director for Prostate and GU Cancer Research Program at Winship Cancer Institute of Emory University. She is a Professor in the Coulter Department of Biomedical Engineering at Georgia Tech-Emory and a Professor of Human Genetics, where she acts as the Faculty Lead for Cancer Genomics & Epigenomics at Emory.

Dr. Yu received her Bachelor of Medicine (equivalent to MD in US) at Peking University, Health Science Center in Beijing. She received her PhD in Biomedical Engineering with concentration on Biotechnology and Bioinformatics from the University of Michigan. Prior to joining the faculty at Emory in 2023, Dr. Yu held a position as a Professor in the Department of Medicine in the division of Hematology/Oncology and of Biochemistry and Molecular Genetics at the Northwestern University of Chicago, Illinois.

She has trained over 40 fellows and graduate students, served on over 30 PhD thesis committees and published nearly 90 articles in prestigious journals such as Nature Genetics, Molecular Cell, and the Journal of Clinical Investigation. Dr. Yu is the Fray F. Marshall Chair in Biomedical Urologic Research and Professor of Urology and Human Genetics. Dr. Yu serves as the Vice Chair for Research in the Department of Urology and Scientific Director for Prostate and GU Cancers Research at Winship based primarily at Winship Cancer Institute.

Academic Appointment

  • Professor, Secondary Appointment, Department of Human Genetics, Emory University School of Medicine
  • Vice Chair of Research, Department of Urology, Emory University School of Medicine
  • Professor of Urology, Primary Appointment, Department of Urology, Emory University School of Medicine

Education

Degrees

  • PhD from University of Michigan–Ann Arbor
  • MS from University of Michigan–Ann Arbor
  • MD from Peking University

Research

Publications

  • Tumor-intrinsic regulators of the immune-cold microenvironment of prostate cancer.
    Trends Endocrinol Metab
    01/02/2025 Authors: Brea L; Yu J
  • Neuroendocrine gene subsets are uniquely dysregulated in prostate adenocarcinoma.
    Cancer Biol Ther Volume: 25 Page(s): 2364433
    12/31/2024 Authors: Naranjo NM; Kennedy A; Testa A; Verrillo CE; Altieri AD; Kean R; Hooper DC; Yu J; Zhao J; Abinader O
  • Myeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential therapeutic target.
    Oncogene Volume: 43 Page(s): 484 - 494
    02/01/2024 Authors: Ferrari MG; Jimenez-Uribe AP; Wang L; Hoeppner LH; Murugan P; Hahm E; Yu J; Kuzel TM; Gradilone SA; Mansini AP
  • Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth.
    J Clin Invest Volume: 133
    08/01/2023 Authors: Gritsina G; Fong K-W; Lu X; Lin Z; Xie W; Agarwal S; Lin D; Schiltz GE; Beltran H; Corey E
  • Myeloid differentiation factor-2/LY96, a new predictive biomarker of metastasis in prostate cancer: Clinical implications as a potential therapeutic target.
    Res Sq
    06/09/2023 Authors: Ferrari M; Wang L; Hoeppner L; Hahm E; Yu J; Kuzel T; Mansini A
  • Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer.
    Oncogene Volume: 42 Page(s): 2126 - 2138
    06/01/2023 Authors: Lin Z; Agarwal S; Tan S; Shi H; Lu X; Tao Z; Dong X; Wu X; Zhao JC; Yu J
  • Ferroptosis: the vulnerability within a cancer monster.
    J Clin Invest Volume: 133
    05/15/2023 Authors: Xie W; Agarwal S; Yu J
  • CXCR7 as a novel therapeutic target for advanced prostate cancer.
    Oncogene Volume: 42 Page(s): 785 - 792
    03/01/2023 Authors: Gritsina G; Yu J
  • PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing.
    Mol Cell Volume: 82 Page(s): 4611 - 4626.e7
    12/15/2022 Authors: Fong K-W; Zhao JC; Lu X; Kim J; Piunti A; Shilatifard A; Yu J
  • FOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A.
    Oncogene Volume: 41 Page(s): 4259 - 4270
    09/01/2022 Authors: Wang X; Brea L; Lu X; Gritsina G; Park SH; Xie W; Zhao JC; Yu J
  • A Genome-Wide CRISPR Activation Screen Identifies PRRX2 as a Regulator of Enzalutamide Resistance in Prostate Cancer.
    Cancer Res Volume: 82 Page(s): 2110 - 2123
    06/06/2022 Authors: Rodrguez Y; Unno K; Truica MI; Chalmers ZR; Yoo YA; Vatapalli R; Sagar V; Yu J; Lysy B; Hussain M
  • The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.
    Cell Mol Life Sci Volume: 79 Page(s): 285
    05/09/2022 Authors: Topchu I; Pangeni RP; Bychkov I; Miller SA; Izumchenko E; Yu J; Golemis E; Karanicolas J; Boumber Y
  • HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer.
    Nat Genet Volume: 54 Page(s): 670 - 683
    05/01/2022 Authors: Lu X; Fong K-W; Gritsina G; Wang F; Baca SC; Brea LT; Berchuck JE; Spisak S; Ross J; Morrissey C
  • Going beyond Polycomb: EZH2 functions in prostate cancer.
    Oncogene Volume: 40 Page(s): 5788 - 5798
    09/01/2021 Authors: Park SH; Fong K-W; Mong E; Martin MC; Schiltz GE; Yu J
  • Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer.
    Sci Adv Volume: 7
    04/01/2021 Authors: Park SH; Fong K-W; Kim J; Wang F; Lu X; Lee Y; Brea LT; Wadosky K; Guo C; Abdulkadir SA
  • Small Molecule Approaches for Targeting the Polycomb Repressive Complex 2 (PRC2) in Cancer.
    J Med Chem Volume: 63 Page(s): 15344 - 15370
    12/24/2020 Authors: Martin MC; Zeng G; Yu J; Schiltz GE
  • Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.
    Nat Commun Volume: 11 Page(s): 4153
    08/19/2020 Authors: Vatapalli R; Sagar V; Rodriguez Y; Zhao JC; Unno K; Pamarthy S; Lysy B; Anker J; Han H; Yoo YA
  • Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice.
    Sci Adv Volume: 6 Page(s): eabb7238
    08/01/2020 Authors: Do-Umehara HC; Chen C; Zhang Q; Misharin AV; Abdala-Valencia H; Casalino-Matsuda SM; Reyfman PA; Anekalla KR; Gonzalez-Gonzalez FJ; Sala MA
  • Correction: Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer.
    Cancer Res Volume: 80 Page(s): 2072
    05/15/2020 Authors: Li S; Fong K-W; Gritsina G; Zhang A; Zhao JC; Kim J; Sharp A; Yuan W; Aversa C; Yang XJ
  • BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer.
    Oncogene Volume: 39 Page(s): 17 - 29
    01/01/2020 Authors: Zhu S; Zhao D; Li C; Li Q; Jiang W; Liu Q; Wang R; Fazli L; Li Y; Zhang L
  • Novel discoveries in urology: big data to microbiome - highlights of the society for basic urologic research 2019 annual meeting.
    Am J Clin Exp Urol Volume: 8 Page(s): 73 - 75
    01/01/2020 Authors: Jin B; Prins GS; Adam R; Yu J; Sfanos KS; Li B; Hu C-D; Dong Y; You Z
  • Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression.
    Cell Res Volume: 29 Page(s): 773 - 775
    09/01/2019 Authors: Xu B; Song B; Lu X; Kim J; Hu M; Zhao JC; Yu J
  • N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer.
    J Clin Invest Volume: 129 Page(s): 3924 - 3940
    07/01/2019 Authors: Berger A; Brady NJ; Bareja R; Robinson B; Conteduca V; Augello MA; Puca L; Ahmed A; Dardenne E; Lu X
  • Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer.
    Cancer Res Volume: 79 Page(s): 2580 - 2592
    05/15/2019 Authors: Li S; Fong K-W; Gritsina G; Zhang A; Zhao JC; Kim J; Sharp A; Yuan W; Aversa C; Yang XJ
  • Targeting FOXA1-mediated repression of TGF- signaling suppresses castration-resistant prostate cancer progression.
    J Clin Invest Volume: 129 Page(s): 569 - 582
    02/01/2019 Authors: Song B; Park S-H; Zhao JC; Fong K-W; Li S; Lee Y; Yang YA; Sridhar S; Lu X; Abdulkadir SA
  • Immune modulatory functions of EZH2 in the tumor microenvironment: implications in cancer immunotherapy.
    Am J Clin Exp Urol Volume: 7 Page(s): 85 - 91
    01/01/2019 Authors: Wang X; Brea LT; Yu J
  • Transcriptional repression by androgen receptor: roles in castration-resistant prostate cancer.
    Asian J Androl Volume: 21 Page(s): 215 - 223
    01/01/2019 Authors: Gritsina G; Gao W-Q; Yu J
  • Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator.
    Cell Rep Volume: 25 Page(s): 2808 - 2820.e4
    12/04/2018 Authors: Kim J; Lee Y; Lu X; Song B; Fong K-W; Cao Q; Licht JD; Zhao JC; Yu J
  • TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.
    Nat Commun Volume: 9 Page(s): 5007
    11/27/2018 Authors: Fong K-W; Zhao JC; Song B; Zheng B; Yu J
  • Trinucleotide Repeat Expansion Diseases, RNAi, and Cancer.
    Trends Cancer Volume: 4 Page(s): 684 - 700
    10/01/2018 Authors: Murmann AE; Yu J; Opal P; Peter ME
  • USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
    Blood Volume: 132 Page(s): 423 - 434
    07/26/2018 Authors: Melo-Cardenas J; Xu Y; Wei J; Tan C; Kong S; Gao B; Montauti E; Kirsammer G; Licht JD; Yu J
  • Ligand-independent CXCR7 activation of MAPK signaling leads to prostate cancer enzalutamide resistance
    Volume: 78
    07/01/2018 Authors: Li S; Fong K-W; Gritsina G; Zhang A; Zhao JC; Kim J; Yu J
  • A novel role for polycomb group protein BMI1 in prostate cancer
    Volume: 78
    07/01/2018 Authors: Zhu S; Zhang D; Yan L; Jiang W; Liu Q; Wang R; Xia B; Zhao JC; Wang R-F; Shi X
  • In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration.
    Gastroenterology Volume: 155 Page(s): 144 - 155
    07/01/2018 Authors: Geng H; Bu H-F; Liu F; Wu L; Pfeifer K; Chou PM; Wang X; Sun J; Lu L; Pandey A
  • PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin 2 expression.
    EMBO Rep Volume: 19
    06/01/2018 Authors: Liu H; Dai X; Cao X; Yan H; Ji X; Zhang H; Shen S; Si Y; Zhang H; Chen J
  • BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1.
    Nat Commun Volume: 9 Page(s): 500
    02/05/2018 Authors: Zhu S; Zhao D; Yan L; Jiang W; Kim J-S; Gu B; Liu Q; Wang R; Xia B; Zhao JC
  • PADI2-Mediated Citrullination Promotes Prostate Cancer Progression.
    Cancer Res Volume: 77 Page(s): 5755 - 5768
    11/01/2017 Authors: Wang L; Song G; Zhang X; Feng T; Pan J; Chen W; Yang M; Bai X; Pang Y; Yu J
  • FOXA1 inhibits prostate cancer neuroendocrine differentiation.
    Oncogene Volume: 36 Page(s): 4072 - 4080
    07/13/2017 Authors: Kim J; Jin H; Zhao JC; Yang YA; Li Y; Yang X; Dong X; Yu J
  • Racial disparities in prostate cancer outcome among prostate-specific antigen screening eligible populations in the United States.
    Ann Oncol Volume: 28 Page(s): 1098 - 1104
    05/01/2017 Authors: Mahal BA; Chen Y-W; Muralidhar V; Mahal AR; Choueiri TK; Hoffman KE; Hu JC; Sweeney CJ; Yu JB; Feng FY
  • CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.
    Cell Rep Volume: 18 Page(s): 2373 - 2386
    03/07/2017 Authors: Qadir AS; Ceppi P; Brockway S; Law C; Mu L; Khodarev NN; Kim J; Zhao JC; Putzbach W; Murmann AE
  • Polycomb-Mediated Disruption of an Androgen Receptor Feedback Loop Drives Castration-Resistant Prostate Cancer.
    Cancer Res Volume: 77 Page(s): 412 - 422
    01/15/2017 Authors: Fong K-W; Zhao JC; Kim J; Li S; Yang YA; Song B; Rittie L; Hu M; Yang X; Perbal B
  • FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.
    Nucleic Acids Res Volume: 44 Page(s): 8153 - 8164
    09/30/2016 Authors: Yang YA; Zhao JC; Fong K-W; Kim J; Li S; Song C; Song B; Zheng B; He C; Yu J
  • FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression.
    Oncogene Volume: 35 Page(s): 4335 - 4344
    08/18/2016 Authors: Zhao JC; Fong K-W; Jin H-J; Yang YA; Kim J; Yu J
  • KAT8 Regulates Androgen Signaling in Prostate Cancer Cells.
    Mol Endocrinol Volume: 30 Page(s): 925 - 936
    08/01/2016 Authors: Kim J-Y; Yu J; Abdulkadir SA; Chakravarti D
  • The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation.
    BMC Genomics Volume: 17 Page(s): 335
    05/04/2016 Authors: Zhao J; Li X; Guo M; Yu J; Yan C
  • LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer.
    Oncogene Volume: 35 Page(s): 2746 - 2755
    05/01/2016 Authors: Xue X; Yang YA; Zhang A; Fong K-W; Kim J; Song B; Li S; Zhao JC; Yu J
  • MiR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition.
    Oncotarget Volume: 6 Page(s): 35978 - 35990
    11/03/2015 Authors: Wang L; Song G; Tan W; Qi M; Zhang L; Chan J; Yu J; Han J; Han B
  • LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer.
    Cell Rep Volume: 13 Page(s): 209 - 221
    10/06/2015 Authors: Zhang A; Zhao JC; Kim J; Fong K-W; Yang YA; Chakravarti D; Mo Y-Y; Yu J
  • The role of TXNDC5 in castration-resistant prostate cancer-involvement of androgen receptor signaling pathway.
    Oncogene Volume: 34 Page(s): 4735 - 4745
    09/03/2015 Authors: Wang L; Song G; Chang X; Tan W; Pan J; Zhu X; Liu Z; Qi M; Yu J; Han B
  • A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis.
    Cell Res Volume: 25 Page(s): 997 - 1012
    09/01/2015 Authors: Shen S; Guo X; Yan H; Lu Y; Ji X; Li L; Liang T; Zhou D; Feng X-H; Zhao JC
  • Current perspectives on FOXA1 regulation of androgen receptor signaling and prostate cancer.
    Genes Dis Volume: 2 Page(s): 144 - 151
    06/01/2015 Authors: Yang YA; Yu J
  • TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c.
    Oncogene Volume: 33 Page(s): 5183 - 5192
    10/30/2014 Authors: Kim J; Wu L; Zhao JC; Jin H-J; Yu J
  • Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program.
    Nat Commun Volume: 5 Page(s): 3972
    05/30/2014 Authors: Jin H-J; Zhao JC; Wu L; Kim J; Yu J
  • CCN3/NOV gene expression in human prostate cancer is directly suppressed by the androgen receptor.
    Oncogene Volume: 33 Page(s): 504 - 513
    01/23/2014 Authors: Wu L; Runkle C; Jin H-J; Yu J; Li J; Yang X; Kuzel T; Lee C; Yu J
  • Influence of oncogenic transcription factors on chromatin conformation and implications in prostate cancer.
    Appl Clin Genet Volume: 7 Page(s): 81 - 91
    01/01/2014 Authors: Yang YA; Kim J; Yu J
  • ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancer.
    Cancer Res Volume: 73 Page(s): 6068 - 6079
    10/01/2013 Authors: Wu L; Zhao JC; Kim J; Jin H-J; Wang C-Y; Yu J
  • Androgen receptor genomic regulation.
    Transl Androl Urol Volume: 2 Page(s): 157 - 177
    09/01/2013 Authors: Jin H-J; Kim J; Yu J
  • Androgen receptor-independent function of FoxA1 in prostate cancer metastasis.
    Cancer Res Volume: 73 Page(s): 3725 - 3736
    06/15/2013 Authors: Jin H-J; Zhao JC; Ogden I; Bergan RC; Yu J
  • The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer.
    Oncogene Volume: 32 Page(s): 2882 - 2890
    06/06/2013 Authors: Ezponda T; Popovic R; Shah MY; Martinez-Garcia E; Zheng Y; Min D-J; Will C; Neri A; Kelleher NL; Yu J
  • BRCA1 is a negative modulator of the PRC2 complex.
    EMBO J Volume: 32 Page(s): 1584 - 1597
    05/29/2013 Authors: Wang L; Zeng X; Chen S; Ding L; Zhong J; Zhao JC; Wang L; Sarver A; Koller A; Zhi J
  • EZH2, an epigenetic driver of prostate cancer.
    Protein Cell Volume: 4 Page(s): 331 - 341
    05/01/2013 Authors: Yang YA; Yu J
  • Interrogating genomic and epigenomic data to understand prostate cancer.
    Biochim Biophys Acta Volume: 1825 Page(s): 186 - 196
    04/01/2012 Authors: Kim J; Yu J
  • Cooperation between Polycomb and androgen receptor during oncogenic transformation.
    Genome Res Volume: 22 Page(s): 322 - 331
    02/01/2012 Authors: Zhao JC; Yu J; Runkle C; Wu L; Hu M; Wu D; Liu JS; Wang Q; Qin ZS; Yu J
  • Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis.
    Genes Dev Volume: 26 Page(s): 54 - 68
    01/01/2012 Authors: Zhao B; Li L; Wang L; Wang C-Y; Yu J; Guan K-L
  • Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer.
    Cancer Res Volume: 71 Page(s): 6738 - 6748
    11/01/2011 Authors: Zhang C; Wang L; Wu D; Chen H; Chen Z; Thomas-Ahner JM; Zynger DL; Eeckhoute J; Yu J; Luo J
  • Coordinated regulation of polycomb group complexes through microRNAs in cancer.
    Cancer Cell Volume: 20 Page(s): 187 - 199
    08/16/2011 Authors: Cao Q; Mani R-S; Ateeq B; Dhanasekaran SM; Asangani IA; Prensner JR; Kim JH; Brenner JC; Jing X; Cao X
  • Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer.
    Genome Res Volume: 21 Page(s): 1028 - 1041
    07/01/2011 Authors: Kim JH; Dhanasekaran SM; Prensner JR; Cao X; Robinson D; Kalyana-Sundaram S; Huang C; Shankar S; Jing X; Iyer M
  • Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.
    Cancer Cell Volume: 19 Page(s): 664 - 678
    05/17/2011 Authors: Brenner JC; Ateeq B; Li Y; Yocum AK; Cao Q; Asangani IA; Patel S; Wang X; Liang H; Yu J
  • Mechanistic rationale for inhibition of Poly(ADP-Ribose) Polymerase in ETS gene fusion positive prostate cancer
    Volume: 71
    04/15/2011 Authors: Brenner JC; Ateeq B; Li Y; Yocum A; Cao Q; Asangani I; Patel S; Liang H; Yu J; Palanisamy N
  • DNA methylation patterns and transcript isoform regulation in prostate cancer
    CANCER RESEARCH Volume: 71
    04/15/2011 Authors: Dhanasekaran SM; Kim JJH; Prensner J; Cao X; Robinson D; Kalyana-Sundaram S; Shankar S; Jing X; Iyer M; Sam L
  • The origins and functional consequences of ETS gene fusions in prostate cancer
    Volume: 71
    04/15/2011 Authors: Mani RS; Tomlins SA; Brenner CJ; Wang L; Iyer M; Yu J; Cao Q; Callahan K; Ghosh A; Nyati MK
  • The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.
    Genes Dev Volume: 25 Page(s): 673 - 678
    04/01/2011 Authors: Kappes F; Waldmann T; Mathew V; Yu J; Zhang L; Khodadoust MS; Chinnaiyan AM; Luger K; Erhardt S; Schneider R
  • Cancer cell migration: when red light switched to green.
    Asian J Androl Volume: 13 Page(s): 177 - 178
    03/01/2011 Authors: Corey SJ; Yu J
  • ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression.
    Neoplasia Volume: 12 Page(s): 1031 - 1040
    12/01/2010 Authors: Rickman DS; Chen Y-B; Banerjee S; Pan Y; Yu J; Vuong T; Perner S; Lafargue CJ; Mertz KD; Setlur SR
  • Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp.
    Cancer Res Volume: 70 Page(s): 8347 - 8356
    11/01/2010 Authors: Pichot CS; Arvanitis C; Hartig SM; Jensen SA; Bechill J; Marzouk S; Yu J; Frost JA; Corey SJ
  • The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer.
    Oncogene Volume: 29 Page(s): 5370 - 5380
    09/30/2010 Authors: Yu J; Cao Q; Yu J; Wu L; Dallol A; Li J; Chen G; Grasso C; Cao X; Lonigro RJ
  • Re: Florian Jentzmik, Carsten Stephan, Kurt Miller, et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours. Eur Urol 2010;58:12-8.
    Eur Urol Volume: 58 Page(s): e29 - e30
    09/01/2010 Authors: Sreekumar A; Poisson LM; Rajendiran TM; Khan AP; Cao Q; Yu J; Laxman B; Mehra R; Lonigro RJ; Li Y
  • HPeak: an HMM-based algorithm for defining read-enriched regions in ChIP-Seq data.
    BMC Bioinformatics Volume: 11 Page(s): 369
    07/02/2010 Authors: Qin ZS; Yu J; Shen J; Maher CA; Hu M; Kalyana-Sundaram S; Yu J; Chinnaiyan AM
  • The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation.
    Genes Dev Volume: 24 Page(s): 1106 - 1118
    06/01/2010 Authors: Lian I; Kim J; Okazawa H; Zhao J; Zhao B; Yu J; Chinnaiyan A; Israel MA; Goldstein LSB; Abujarour R
  • An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
    Cancer Cell Volume: 17 Page(s): 443 - 454
    05/18/2010 Authors: Yu J; Yu J; Mani R-S; Cao Q; Brenner CJ; Cao X; Wang X; Wu L; Li J; Hu M
  • On the detection and refinement of transcription factor binding sites using ChIP-Seq data.
    Nucleic Acids Res Volume: 38 Page(s): 2154 - 2167
    04/01/2010 Authors: Hu M; Yu J; Taylor JMG; Chinnaiyan AM; Qin ZS
  • Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases.
    PLoS One Volume: 4 Page(s): e7075
    09/18/2009 Authors: Vellaichamy A; Sreekumar A; Strahler JR; Rajendiran T; Yu J; Varambally S; Li Y; Omenn GS; Chinnaiyan AM; Nesvizhskii AI
  • Chimeric transcript discovery by paired-end transcriptome sequencing.
    Proc Natl Acad Sci U S A Volume: 106 Page(s): 12353 - 12358
    07/28/2009 Authors: Maher CA; Palanisamy N; Brenner JC; Cao X; Kalyana-Sundaram S; Luo S; Khrebtukova I; Barrette TR; Grasso C; Yu J
  • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.
    Cell Volume: 138 Page(s): 245 - 256
    07/23/2009 Authors: Wang Q; Li W; Zhang Y; Yuan X; Xu K; Yu J; Chen Z; Beroukhim R; Wang H; Lupien M
  • Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.
    Nature Volume: 457 Page(s): 910 - 914
    02/12/2009 Authors: Sreekumar A; Poisson LM; Rajendiran TM; Khan AP; Cao Q; Yu J; Laxman B; Mehra R; Lonigro RJ; Li Y
  • Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.
    Science Volume: 322 Page(s): 1695 - 1699
    12/12/2008 Authors: Varambally S; Cao Q; Mani R-S; Shankar S; Wang X; Ateeq B; Laxman B; Cao X; Jing X; Ramnarayanan K
  • Repression of E-cadherin by the polycomb group protein EZH2 in cancer.
    Oncogene Volume: 27 Page(s): 7274 - 7284
    12/11/2008 Authors: Cao Q; Yu J; Dhanasekaran SM; Kim JH; Mani R-S; Tomlins SA; Mehra R; Laxman B; Cao X; Yu J
  • A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancer.
    Cancer Res Volume: 68 Page(s): 7629 - 7637
    09/15/2008 Authors: Han B; Mehra R; Dhanasekaran SM; Yu J; Menon A; Lonigro RJ; Wang X; Gong Y; Wang L; Shankar S
  • TEAD mediates YAP-dependent gene induction and growth control.
    Genes Dev Volume: 22 Page(s): 1962 - 1971
    07/15/2008 Authors: Zhao B; Ye X; Yu J; Li L; Li W; Li S; Yu J; Lin JD; Wang C-Y; Chinnaiyan AM
  • Role of the TMPRSS2-ERG gene fusion in prostate cancer.
    Neoplasia Volume: 10 Page(s): 177 - 188
    02/01/2008 Authors: Tomlins SA; Laxman B; Varambally S; Cao X; Yu J; Helgeson BE; Cao Q; Prensner JR; Rubin MA; Shah RB
  • A transcriptional fingerprint of estrogen in human breast cancer predicts patient survival.
    Neoplasia Volume: 10 Page(s): 79 - 88
    01/01/2008 Authors: Yu J; Yu J; Cordero KE; Johnson MD; Ghosh D; Rae JM; Chinnaiyan AM; Lippman ME
  • A polycomb repression signature in metastatic prostate cancer predicts cancer outcome.
    Cancer Res Volume: 67 Page(s): 10657 - 10663
    11/15/2007 Authors: Yu J; Yu J; Rhodes DR; Tomlins SA; Cao X; Chen G; Mehra R; Wang X; Ghosh D; Shah RB
  • Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer.
    Cancer Cell Volume: 12 Page(s): 419 - 431
    11/01/2007 Authors: Yu J; Cao Q; Mehra R; Laxman B; Yu J; Tomlins SA; Creighton CJ; Dhanasekaran SM; Shen R; Chen G
  • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
    Genes Dev Volume: 21 Page(s): 2747 - 2761
    11/01/2007 Authors: Zhao B; Wei X; Li W; Udan RS; Yang Q; Kim J; Xie J; Ikenoue T; Yu J; Li L
  • Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer.
    Nature Volume: 448 Page(s): 595 - 599
    08/02/2007 Authors: Tomlins SA; Laxman B; Dhanasekaran SM; Helgeson BE; Cao X; Morris DS; Menon A; Jing X; Cao Q; Han B
  • Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinoma.
    Cancer Res Volume: 67 Page(s): 3461 - 3467
    04/01/2007 Authors: Chen G; Wang X; Yu J; Varambally S; Yu J; Thomas DG; Lin M-Y; Vishnu P; Wang Z; Wang R
  • Feature selection and molecular classification of cancer using genetic programming.
    Neoplasia Volume: 9 Page(s): 292 - 303
    04/01/2007 Authors: Yu J; Yu J; Almal AA; Dhanasekaran SM; Ghosh D; Worzel WP; Chinnaiyan AM
  • Identification and analysis of differential humoral response targets in prostate cancer
    Volume: 5 Page(s): S306 - S306
    10/01/2006 Authors: Taylor BS; Sreekumar A; Pal M; Yu J; Shen R; Zhao R; Wei JT; Ghosh D; Lubman DM; Chinnaiyan AM
  • Altered expression of genes of the Bmp/Smad and Wnt/calcium signaling pathways in the cone-only Nrl-/- mouse retina, revealed by gene profiling using custom cDNA microarrays.
    J Biol Chem Volume: 279 Page(s): 42211 - 42220
    10/01/2004 Authors: Yu J; He S; Friedman JS; Akimoto M; Ghosh D; Mears AJ; Hicks D; Swaroop A
  • From disease genes to cellular pathways: a progress report.
    Novartis Found Symp Volume: 255 Page(s): 147 - 160
    01/01/2004 Authors: Yu J; Mears AJ; Yoshida S; Farjo R; Carter TA; Ghosh D; Hero A; Barlow C; Swaroop A
  • Annotation and analysis of 10,000 expressed sequence tags from developing mouse eye and adult retina.
    Genome Biol Volume: 4 Page(s): R65
    01/01/2003 Authors: Yu J; Farjo R; MacNee SP; Baehr W; Stambolian DE; Swaroop A
  • Evaluation and optimization of procedures for target labeling and hybridization of cDNA microarrays.
    Mol Vis Volume: 8 Page(s): 130 - 137
    04/26/2002 Authors: Yu J; Othman MI; Farjo R; Zareparsi S; MacNee SP; Yoshida S; Swaroop A
  • Mouse eye gene microarrays for investigating ocular development and disease.
    Vision Res Volume: 42 Page(s): 463 - 470
    02/01/2002 Authors: Farjo R; Yu J; Othman MI; Yoshida S; Sheth S; Glaser T; Baehr W; Swaroop A
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