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Profile

Joy Feng

  • Department of Pediatrics
    Associate Professor
  • (404) 727-1451
  • joy.yang.feng@emory.edu
  • Emory University
    HSRB-1 Room E 430
    1760 Haygood Drive
Head shot of Joy Feng

Overview

I am an Associate Professor in the Department of Pediatrics and an AssociateDirector in the Division of the Laboratory of Biochemical Pharmacology (LOBP). I joined Emory in February 2025 and brought 25 years of expertise and experience in pre-clinical drug discovery in HIV, HCV, respiratory viruses, and emerging viruses at a leading pharmaceutical company. I am one of the inventors of Remdesivir, the first FDA-approved antiviral to treat COVID, and Obeldesivir, the orally available form under development for emerging viruses. My primary research interests are antiviral nucleoside and nucleotide analogs, viral polymerases, drug resistance, toxicity and off-target evaluation/mechanism of action, and drug metabolizing enzymes/activation pathways, but most importantly, how to advance a drug from bench to bed to address the unmet medical needs.

Research

Publications

  • Lack of activity of HIV-1 integrase strand-transfer inhibitors on recombinase activating gene (RAG) activity at clinically relevant concentrations.
    Microbiol Spectr Volume: 13 Page(s): e0246824
    01/07/2025 Authors: Demirdjian S; Duong VN; Byrum JN; Nayak A; McKinney CB; Perry JK; Callebaut C; Rodgers KK; Falkard B; Feng JY
  • Meeting report of the 37th International Conference on Antiviral Research in Gold Coast, Australia, May 20-24, 2024, organized by the International Society for Antiviral Research.
    Antiviral Res Volume: 232 Page(s): 106037
    12/01/2024 Authors: Welch SR; Bilello JP; Carter K; Delang L; Dirr L; Durantel D; Feng JY; Gowen BB; Herrero LJ; Janeba Z
  • Discovery of GS-7682, a Novel 4'-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.
    J Med Chem Volume: 67 Page(s): 12945 - 12968
    08/08/2024 Authors: Siegel DS; Hui HC; Pitts J; Vermillion MS; Ishida K; Rautiola D; Keeney M; Irshad H; Zhang L; Chun K
  • Mechanism and spectrum of inhibition of a 4'-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses.
    J Biol Chem Volume: 300 Page(s): 107514
    08/01/2024 Authors: Gordon CJ; Walker SM; Tchesnokov EP; Kocincova D; Pitts J; Siegel DS; Perry JK; Feng JY; Bilello JP; Gtte M
  • The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.
    Sci Transl Med Volume: 16 Page(s): eadj4504
    05/22/2024 Authors: Martinez DR; Moreira FR; Catanzaro NJ; Diefenbacher MV; Zweigart MR; Gully KL; De la Cruz G; Brown AJ; Adams LE; Yount B
  • Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys.
    J Med Chem Volume: 66 Page(s): 11701 - 11717
    09/14/2023 Authors: Mackman RL; Kalla RV; Babusis D; Pitts J; Barrett KT; Chun K; Du Pont V; Rodriguez L; Moshiri J; Xu Y
  • Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro.
    Sci Rep Volume: 13 Page(s): 3131
    02/23/2023 Authors: Radoshitzky SR; Iversen P; Lu X; Zou J; Kaptein SJF; Stuthman KS; Van Tongeren SA; Steffens J; Gong R; Truong H
  • Structural basis for substrate selection by the SARS-CoV-2 replicase.
    Nature Volume: 614 Page(s): 781 - 787
    02/01/2023 Authors: Malone BF; Perry JK; Olinares PDB; Lee HW; Chen J; Appleby TC; Feng JY; Bilello JP; Ng H; Sotiris J
  • Interfering with nucleotide excision by the coronavirus 3'-to-5' exoribonuclease.
    Nucleic Acids Res Volume: 51 Page(s): 315 - 336
    01/11/2023 Authors: Chinthapatla R; Sotoudegan M; Srivastava P; Anderson TK; Moustafa IM; Passow KT; Kennelly SA; Moorthy R; Dulin D; Feng JY
  • The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2.
    Molecules Volume: 27
    06/30/2022 Authors: Feng JY; Du Pont V; Babusis D; Gordon CJ; Tchesnokov EP; Perry JK; Duong V; Vijjapurapu A; Zhao X; Chan J
  • Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice.
    Sci Transl Med Volume: 14 Page(s): eabm3410
    05/04/2022 Authors: Schfer A; Martinez DR; Won JJ; Meganck RM; Moreira FR; Brown AJ; Gully KL; Zweigart MR; Conrad WS; May SR
  • Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir.
    J Biol Chem Volume: 298 Page(s): 101529
    02/01/2022 Authors: Gordon CJ; Lee HW; Tchesnokov EP; Perry JK; Feng JY; Bilello JP; Porter DP; Gtte M
  • Semi-Mechanistic PK/PD Modeling and Simulation of Irreversible BTK Inhibition to Support Dose Selection of Tirabrutinib in Subjects with RA.
    Clin Pharmacol Ther Volume: 111 Page(s): 416 - 424
    02/01/2022 Authors: Meng A; Humeniuk R; Jrgensmeier JM; Hsueh C-H; Matzkies F; Grant E; Truong H; Billin AN; Yu H; Feng J
  • Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus.
    PLoS One Volume: 17 Page(s): e0271145
    01/01/2022 Authors: Gilmore SA; Tam D; Cheung TL; Snyder C; Farand J; Dick R; Matles M; Feng JY; Ramirez R; Li L
  • An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15.
    J Biol Chem Volume: 297 Page(s): 101218
    10/01/2021 Authors: Perry JK; Appleby TC; Bilello JP; Feng JY; Schmitz U; Campbell EA
  • Reply to Yan and Muller, "Single-Cell RNA Sequencing Supports Preferential Bioactivation of Remdesivir in the Liver".
    Antimicrob Agents Chemother Volume: 65 Page(s): e0139421
    09/17/2021 Authors: Murakami E; Bilello J; Li R; Li L; Porter D; Humeniuk R; Mackman R; Cihlar T; Osinusi A; Feng J
  • Species-Specific Urothelial Toxicity With an Anti-HIV Noncatalytic Site Integrase Inhibitor (NCINI) Is Related to Unusual pH-Dependent Physicochemical Changes.
    Toxicol Sci Volume: 183 Page(s): 105 - 116
    08/30/2021 Authors: Roberts RA; Campbell RA; Sikakana P; Sadler C; Osier M; Xu Y; Feng JY; Mitchell M; Sakowicz R; Chester A
  • Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells.
    Antimicrob Agents Chemother Volume: 65 Page(s): e0060221
    08/17/2021 Authors: Li R; Liclican A; Xu Y; Pitts J; Niu C; Zhang J; Kim C; Zhao X; Soohoo D; Babusis D
  • Correction: Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action.
    J Biol Chem Volume: 297 Page(s): 101048
    08/01/2021 Authors: Tchesnokov EP; Gordon CJ; Woolner E; Kocincova D; Perry JK; Feng JY; Porter DP; Gtte M
  • Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice.
    Cell Rep Volume: 36 Page(s): 109450
    07/27/2021 Authors: Martinez DR; Schfer A; Leist SR; Li D; Gully K; Yount B; Feng JY; Bunyan E; Porter DP; Cihlar T
  • Reply to Yan and Muller, "Remdesivir for COVID-19: Why Not Dose Higher?".
    Antimicrob Agents Chemother Volume: 65
    03/18/2021 Authors: Juneja K; Humeniuk R; Porter D; Cao H; Feng J
  • Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent.
    Antimicrob Agents Chemother Volume: 65
    01/20/2021 Authors: Xu Y; Barauskas O; Kim C; Babusis D; Murakami E; Kornyeyev D; Lee G; Stepan G; Perron M; Bannister R
  • Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action.
    J Biol Chem Volume: 295 Page(s): 16156 - 16165
    11/20/2020 Authors: Tchesnokov EP; Gordon CJ; Woolner E; Kocinkova D; Perry JK; Feng JY; Porter DP; Gtte M
  • Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.
    Cell Rep Volume: 32 Page(s): 107940
    07/21/2020 Authors: Pruijssers AJ; George AS; Schfer A; Leist SR; Gralinksi LE; Dinnon KH; Yount BL; Agostini ML; Stevens LJ; Chappell JD
  • Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency.
    J Biol Chem Volume: 295 Page(s): 6785 - 6797
    05/15/2020 Authors: Gordon CJ; Tchesnokov EP; Woolner E; Perry JK; Feng JY; Porter DP; Gtte M
  • The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus.
    J Biol Chem Volume: 295 Page(s): 4773 - 4779
    04/10/2020 Authors: Gordon CJ; Tchesnokov EP; Feng JY; Porter DP; Gtte M
  • Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition.
    Biochim Biophys Acta Gen Subj Volume: 1864 Page(s): 129531
    04/01/2020 Authors: Liclican A; Serafini L; Xing W; Czerwieniec G; Steiner B; Wang T; Brendza KM; Lutz JD; Keegan KS; Ray AS
  • Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.
    Nat Commun Volume: 11 Page(s): 222
    01/10/2020 Authors: Sheahan TP; Sims AC; Leist SR; Schfer A; Won J; Brown AJ; Montgomery SA; Hogg A; Babusis D; Clarke MO
  • Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.
    Antiviral Res Volume: 169 Page(s): 104541
    09/01/2019 Authors: Brown AJ; Won JJ; Graham RL; Dinnon KH; Sims AC; Feng JY; Cihlar T; Denison MR; Baric RS; Sheahan TP
  • Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir.
    Viruses Volume: 11
    04/04/2019 Authors: Tchesnokov EP; Feng JY; Porter DP; Gtte M
  • The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM.
    J Mol Biol Volume: 431 Page(s): 1440 - 1459
    03/29/2019 Authors: Wong MH; Samal AB; Lee M; Vlach J; Novikov N; Niedziela-Majka A; Feng JY; Koltun DO; Brendza KM; Kwon HJ
  • Homogeneous BTK Occupancy Assay for Pharmacodynamic Assessment of Tirabrutinib (GS-4059/ONO-4059) Target Engagement.
    SLAS Discov Volume: 23 Page(s): 919 - 929
    10/01/2018 Authors: Yu H; Truong H; Mitchell SA; Liclican A; Gosink JJ; Li W; Lin J; Feng JY; Jrgensmeier JM; Billin A
  • Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment.
    Antimicrob Agents Chemother Volume: 62
    08/01/2018 Authors: Feng JY; Wang T; Park Y; Babusis D; Birkus G; Xu Y; Voitenleitner C; Fenaux M; Yang H; Eng S
  • Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.
    mBio Volume: 9
    03/06/2018 Authors: Agostini ML; Andres EL; Sims AC; Graham RL; Sheahan TP; Lu X; Smith EC; Case JB; Feng JY; Jordan R
  • Addressing the selectivity and toxicity of antiviral nucleosides.
    Antivir Chem Chemother Volume: 26 Page(s): 2040206618758524
    01/01/2018 Authors: Feng JY
  • Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.
    Sci Transl Med Volume: 9
    06/28/2017 Authors: Sheahan TP; Sims AC; Graham RL; Menachery VD; Gralinski LE; Case JB; Leist SR; Pyrc K; Feng JY; Trantcheva I
  • Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
    Bioorg Med Chem Lett Volume: 27 Page(s): 1840 - 1847
    04/15/2017 Authors: Kirschberg TA; Metobo S; Clarke MO; Aktoudianakis V; Babusis D; Barauskas O; Birkus G; Butler T; Byun D; Chin G
  • Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.
    J Med Chem Volume: 60 Page(s): 1648 - 1661
    03/09/2017 Authors: Siegel D; Hui HC; Doerffler E; Clarke MO; Chun K; Zhang L; Neville S; Carra E; Lew W; Ross B
  • In vitro selection of resistance to sofosbuvir in HCV replicons of genotype-1 to -6.
    Antivir Ther Volume: 22 Page(s): 587 - 597
    01/01/2017 Authors: Xu S; Doehle B; Rajyaguru S; Han B; Barauskas O; Feng J; Perry J; Dvory-Sobol H; Svarovskaia ES; Miller MD
  • Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs.
    PLoS One Volume: 12 Page(s): e0185998
    01/01/2017 Authors: Barauskas O; Xing W; Aguayo E; Willkom M; Sapre A; Clarke M; Birkus G; Schultz BE; Sakowicz R; Kwon H
  • Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.
    PLoS One Volume: 12 Page(s): e0181969
    01/01/2017 Authors: Xing W; Barauskas O; Kirschberg T; Niedziela-Majka A; Clarke M; Birkus G; Weissburg P; Liu X; Schultz BE; Sakowicz R
  • Role of Mitochondrial Toxicity in BMS-986094-Induced Toxicity.
    Toxicol Sci Volume: 155 Page(s): 2
    01/01/2017 Authors: Feng JY; Tay CH; Ray AS
  • Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.
    Nature Volume: 531 Page(s): 381 - 385
    03/17/2016 Authors: Warren TK; Jordan R; Lo MK; Ray AS; Mackman RL; Soloveva V; Siegel D; Perron M; Bannister R; Hui HC
  • Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.
    Antimicrob Agents Chemother Volume: 60 Page(s): 806 - 817
    02/01/2016 Authors: Feng JY; Xu Y; Barauskas O; Perry JK; Ahmadyar S; Stepan G; Yu H; Babusis D; Park Y; McCutcheon K
  • Discovery of -D-2'-deoxy-2'--fluoro-4'--cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases.
    Bioorg Med Chem Lett Volume: 25 Page(s): 2484 - 2487
    06/15/2015 Authors: Clarke MO; Mackman R; Byun D; Hui H; Barauskas O; Birkus G; Chun B-K; Doerffler E; Feng J; Karki K
  • Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
    Bioorg Med Chem Lett Volume: 25 Page(s): 1040 - 1043
    03/01/2015 Authors: Kirschberg TA; Mish MR; Zhang L; Squires NH; Wang K-Y; Cho A; Feng JY; Fenaux M; Babusis D; Park Y
  • Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase.
    Science Volume: 347 Page(s): 771 - 775
    02/13/2015 Authors: Appleby TC; Perry JK; Murakami E; Barauskas O; Feng J; Cho A; Fox D; Wetmore DR; McGrath ME; Ray AS
  • Structural and kinetic insights into binding and incorporation of L-nucleotide analogs by a Y-family DNA polymerase.
    Nucleic Acids Res Volume: 42 Page(s): 9984 - 9995
    09/01/2014 Authors: Gaur V; Vyas R; Fowler JD; Efthimiopoulos G; Feng JY; Suo Z
  • Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
    Bioorg Med Chem Lett Volume: 24 Page(s): 3092 - 3095
    07/15/2014 Authors: Mish MR; Cho A; Kirschberg T; Xu J; Zonte CS; Fenaux M; Park Y; Babusis D; Feng JY; Ray AS
  • Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.
    J Med Chem Volume: 57 Page(s): 1812 - 1825
    03/13/2014 Authors: Cho A; Zhang L; Xu J; Lee R; Butler T; Metobo S; Aktoudianakis V; Lew W; Ye H; Clarke M
  • Dead-end complexes contribute to the synergistic inhibition of HIV-1 RT by the combination of rilpivirine, emtricitabine, and tenofovir.
    Antiviral Res Volume: 101 Page(s): 131 - 135
    01/01/2014 Authors: Kulkarni R; Feng JY; Miller MD; White KL
  • Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
    Antimicrob Agents Chemother Volume: 58 Page(s): 1930 - 1942
    01/01/2014 Authors: Feng JY; Cheng G; Perry J; Barauskas O; Xu Y; Fenaux M; Eng S; Tirunagari N; Peng B; Yu M
  • Evaluation of 2'--fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase.
    Bioorg Med Chem Lett Volume: 23 Page(s): 3354 - 3357
    06/01/2013 Authors: Parrish JP; Lee SK; Boojamra CG; Hui H; Babusis D; Brown B; Shih I-H; Feng JY; Ray AS; Mackman RL
  • Bifunctional inhibition of HIV-1 reverse transcriptase: a first step in designing a bifunctional triphosphate.
    Bioorg Med Chem Lett Volume: 23 Page(s): 1511 - 1518
    03/01/2013 Authors: Piao D; Basavapathruni A; Iyidogan P; Dai G; Hinz W; Ray AS; Murakami E; Feng JY; You F; Dutschman GE
  • Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.
    Bioorg Med Chem Lett Volume: 22 Page(s): 4127 - 4132
    06/15/2012 Authors: Cho A; Zhang L; Xu J; Babusis D; Butler T; Lee R; Saunders OL; Wang T; Parrish J; Perry J
  • Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides.
    Bioorg Med Chem Lett Volume: 22 Page(s): 2705 - 2707
    04/15/2012 Authors: Cho A; Saunders OL; Butler T; Zhang L; Xu J; Vela JE; Feng JY; Ray AS; Kim CU
  • Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides.
    PLoS Pathog Volume: 8 Page(s): e1003030
    01/01/2012 Authors: Arnold JJ; Sharma SD; Feng JY; Ray AS; Smidansky ED; Kireeva ML; Cho A; Perry J; Vela JE; Park Y
  • Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
    J Med Chem Volume: 54 Page(s): 5498 - 5507
    08/11/2011 Authors: Bourderioux A; Naus P; Perlkov P; Pohl R; Pichov I; Votruba I; Dzubk P; Konecn P; Hajdch M; Stray KM
  • Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance.
    J Biol Chem Volume: 284 Page(s): 35092 - 35100
    12/11/2009 Authors: Das K; Bandwar RP; White KL; Feng JY; Sarafianos SG; Tuske S; Tu X; Clark AD; Boyer PL; Hou X
  • Comparison of HCV NS3 protease and NS5B polymerase inhibitor activity in 1a, 1b and 2a replicons and 2a infectious virus.
    Antiviral Res Volume: 83 Page(s): 135 - 142
    08/01/2009 Authors: Paulson MS; Yang H; Shih I-H; Feng JY; Mabery EM; Robinson MF; Zhong W; Delaney WE
  • Nucleoside diphosphate kinase and the activation of antiviral phosphonate analogs of nucleotides: binding mode and phosphorylation of tenofovir derivatives.
    Nucleosides Nucleotides Nucleic Acids Volume: 28 Page(s): 776 - 792
    08/01/2009 Authors: Koch K; Chen Y; Feng JY; Borroto-Esoda K; Deville-Bonne D; Gallois-Montbrun S; Janin J; Morra S
  • The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study.
    Retrovirology Volume: 6 Page(s): 44
    05/13/2009 Authors: Feng JY; Ly JK; Myrick F; Goodman D; White KL; Svarovskaia ES; Borroto-Esoda K; Miller MD
  • The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation.
    J Acquir Immune Defic Syndr Volume: 48 Page(s): 428 - 436
    08/01/2008 Authors: Svarovskaia ES; Feng JY; Margot NA; Myrick F; Goodman D; Ly JK; White KL; Kutty N; Wang R; Borroto-Esoda K
  • Structural basis for K65R function: tenofovir resistance, reduced nucleotide incorporation and excision antagonism
    Volume: 13 Page(s): A44 - A44
    01/01/2008 Authors: Das K; Bandwar R; White KL; Feng JY; Sarafianos SG; Tuske S; Tu X; Clark AD; Boyer PL; Gaffney BL
  • Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma.
    Antivir Chem Chemother Volume: 18 Page(s): 25 - 33
    01/01/2007 Authors: Ray AS; Feng JY; Murakami E; Chu CK; Schinazi RF; Anderson KS
  • The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations.
    Antivir Ther Volume: 11 Page(s): 155 - 163
    01/01/2006 Authors: White KL; Chen JM; Feng JY; Margot NA; Ly JK; Ray AS; Macarthur HL; McDermott MJ; Swaminathan S; Miller MD
  • Virologic and enzymatic studies revealing the mechanism of K65R- and Q151M-associated HIV-1 drug resistance towards emtricitabine and lamivudine.
    Nucleosides Nucleotides Nucleic Acids Volume: 25 Page(s): 89 - 107
    01/01/2006 Authors: Feng JY; Myrick FT; Margot NA; Mulamba GB; Rimsky L; Borroto-Esoda K; Selmi B; Canard B
  • Effects of HIV Q151M-associated multi-drug resistance mutations on the activities of (-)-beta-D-1',3'-dioxolan guanine.
    Antiviral Res Volume: 66 Page(s): 153 - 158
    06/01/2005 Authors: Feng JY; Myrick F; Selmi B; Deval J; Canard B; Borroto-Esoda K
  • In vitro combination of amdoxovir and the inosine monophosphate dehydrogenase inhibitors mycophenolic acid and ribavirin demonstrates potent activity against wild-type and drug-resistant variants of human immunodeficiency virus type 1.
    Antimicrob Agents Chemother Volume: 48 Page(s): 4387 - 4394
    11/01/2004 Authors: Borroto-Esoda K; Myrick F; Feng J; Jeffrey J; Furman P
  • Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases.
    Biochem Pharmacol Volume: 68 Page(s): 1879 - 1888
    11/01/2004 Authors: Feng JY; Parker WB; Krajewski ML; Deville-Bonne D; Veron M; Krishnan P; Cheng Y-C; Borroto-Esoda K
  • Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase.
    Antimicrob Agents Chemother Volume: 48 Page(s): 1300 - 1306
    04/01/2004 Authors: Feng JY; Murakami E; Zorca SM; Johnson AA; Johnson KA; Schinazi RF; Furman PA; Anderson KS
  • Characterization of novel reverse transcriptase and other RNA-associated catalytic activities by human DNA polymerase gamma: importance in mitochondrial DNA replication.
    J Biol Chem Volume: 278 Page(s): 36403 - 36409
    09/19/2003 Authors: Murakami E; Feng JY; Lee H; Hanes J; Johnson KA; Anderson KS
  • Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses.
    J Biol Chem Volume: 278 Page(s): 18971 - 18979
    05/23/2003 Authors: Jeffrey JL; Feng JY; Qi CCR; Anderson KS; Furman PA
  • Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug.
    FASEB J Volume: 15 Page(s): 1902 - 1908
    09/01/2001 Authors: Krynetskaia NF; Feng JY; Krynetski EY; Garcia JV; Panetta JC; Anderson KS; Evans WE
  • Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs.
    J Biol Chem Volume: 276 Page(s): 23832 - 23837
    06/29/2001 Authors: Feng JY; Johnson AA; Johnson KA; Anderson KS
  • Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.
    Antimicrob Agents Chemother Volume: 45 Page(s): 158 - 165
    01/01/2001 Authors: Furman PA; Jeffrey J; Kiefer LL; Feng JY; Anderson KS; Borroto-Esoda K; Hill E; Copeland WC; Chu CK; Sommadossi JP
  • Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP.
    FASEB J Volume: 13 Page(s): 1511 - 1517
    09/01/1999 Authors: Feng JY; Shi J; Schinazi RF; Anderson KS
  • Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase.
    Biochemistry Volume: 38 Page(s): 9440 - 9448
    07/20/1999 Authors: Feng JY; Anderson KS
  • Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase.
    Biochemistry Volume: 38 Page(s): 55 - 63
    01/05/1999 Authors: Feng JY; Anderson KS
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