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Joshua Weinstock

  • Department of Human Genetics
    Assistant Professor

  • 615 Michael St NE, Suite 347
Head shot of Joshua Weinstock

Overview

The Weinstock lab works at the nexus of genetics, biostatistics, and machine learning to discover and characterize disease associated genetic variation. Our interests span both germline and somatic forms of genetic variation, and integrative analyses thereof. In more detail, our interests span two primary axes:
1) Discovery of the germline determinants of somatic mosaicism. Previous and ongoing work leverages biobank scale whole-genome sequencing (WGS) of blood to detect pre-malignant clonal expansions and to discover their germline determinants and phenotypic correlates. We are particularly interested the germline determinants of clonal expansions of somatic point mutations in blood, spanning both leukemogenic point mutations as well as relatively uncharacterized recurrent non-coding point mutations.
2) Characterization of the trans-regulatory cascade of disease-associated regulatory variation discovered by GWAS. We are particularly enthusiastic about high-throughput CRISPR perturbation approaches paired with bespoke statistical methods for computationally inferring gene regulatory networks. Our perspective is that these gene regulatory networks offer rich mechanistic insight into otherwise opaque GWAS loci.

Our lab furthers this mission though bespoke computational methods development and application. Our model has been to partner closely with experimentalists to develop statistical approaches that reflect deep biological and experimental intuition. We ultimately aspire to mitigate common disease burden through our discovery and characterization of novel therapeutic targets.

Read more about our work at weinstocklab.org

Academic Appointment

  • Assistant Professor, Human Genetics, Emory University

Education

Degrees

  • PhD Biostatistics from University of Michigan–Ann Arbor

Research

Publications

Read more publications