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Profile

James Little III MD

  • Department of Pathology and Laboratory Medicine
    Assistant Professor, Emeritus
  • (404) 686-1216
  • jvlittl@emory.edu
Head shot of James Little III

Academic Appointment

  • Assistant ProfessorAssistant Professor, Director of Surgical Pathology (EUHM), Department of Pathology and Laboratory Medicine, Emory University School of Medicine

Education

Degrees

  • MD from Vanderbilt University
  • BA from Vanderbilt University

Research

Focus

  • My non-clinical work has focused on: (1) Support for laboratory services for the Global Aids Program (GAP), in collaboration with the Republic of Botswana Ministry of Health and the Centers for Disease Control and Prevention; (2) Cytology Proficiency Testing; (3) Best practices in Quality Assurance in Pathology and Laboratory Medicine, in collaboration with the University of Pittsburgh and the Centers for Disease Control and Prevention.

Publications

  • Automatic detection of head and neck squamous cell carcinoma on histologic slides using hyperspectral microscopic imaging (Erratum).
    J Biomed Opt Volume: 27
    05/01/2022 Authors: Ma L; Little JV; Chen AY; Myers L; Sumer BD; Fei B
  • Automatic detection of head and neck squamous cell carcinoma on histologic slides using hyperspectral microscopic imaging.
    J Biomed Opt Volume: 27
    04/01/2022 Authors: Ma L; Little JV; Chen AY; Myers L; Sumer BD; Fei B
  • Detecting Aggressive Papillary Thyroid Carcinoma Using Hyperspectral Imaging and Radiomic Features.
    Proc SPIE Int Soc Opt Eng Volume: 12033
    01/01/2022 Authors: Leitch K; Halicek M; Shahedi M; Little JV; Chen AY; Fei B
  • Automatic detection of head and neck squamous cell carcinoma on pathologic slides using polarized hyperspectral imaging and deep learning.
    Volume: 12039
    01/01/2022 Authors: Zhou X; Ma L; Mubarak HK; Little JV; Chen AY; Myers LL; Sumer BD; Fei B
  • Pixel-level Tumor Margin Assessment of Surgical Specimen with Hyperspectral Imaging and Deep Learning Classification.
    Proc SPIE Int Soc Opt Eng Volume: 11598
    02/01/2021 Authors: Ma L; Shahedi M; Shi T; Halicek M; Little JV; Chen AY; Myers LL; Sumer BD; Fei B
  • Multiparametric Radiomics for Predicting the Aggressiveness of Papillary Thyroid Carcinoma Using Hyperspectral Images.
    Proc SPIE Int Soc Opt Eng Volume: 11597
    02/01/2021 Authors: Edwards K; Halicek M; Little JV; Chen AY; Fei B
  • Hyperspectral Microscopic Imaging for the Detection of Head and Neck Squamous Cell Carcinoma on Histologic Slides.
    Proc SPIE Int Soc Opt Eng Volume: 11603
    02/01/2021 Authors: Ma L; Zhou X; Little JV; Chen AY; Myers LL; Sumer BD; Fei B
  • Automatic detection of head and neck squamous cell carcinoma on pathologic slides using polarized hyperspectral imaging and machine learning.
    Proc SPIE Int Soc Opt Eng Volume: 11603
    02/01/2021 Authors: Zhou X; Ma L; Brown W; Little JV; Chen AY; Myers LL; Sumer BD; Fei B
  • Tumor detection of the thyroid and salivary glands using hyperspectral imaging and deep learning.
    Biomed Opt Express Volume: 11 Page(s): 1383 - 1400
    03/01/2020 Authors: Halicek M; Dormer JD; Little JV; Chen AY; Fei B
  • Using a 22-Layer U-Net to Perform Segmentation of Squamous Cell Carcinoma on Digitized Head and Neck Histological Images.
    Proc SPIE Int Soc Opt Eng Volume: 11320
    02/01/2020 Authors: Mavuduru A; Halicek M; Shahedi M; Little JV; Chen AY; Myers LL; Fei B
  • Histopathology Feature Mining and Association with Hyperspectral Imaging for the Detection of Squamous Neoplasia.
    Sci Rep Volume: 9 Page(s): 17863
    11/28/2019 Authors: Lu G; Wang D; Qin X; Muller S; Little JV; Wang X; Chen AY; Chen G; Fei B
  • Head and Neck Cancer Detection in Digitized Whole-Slide Histology Using Convolutional Neural Networks.
    Sci Rep Volume: 9 Page(s): 14043
    10/01/2019 Authors: Halicek M; Shahedi M; Little JV; Chen AY; Myers LL; Sumer BD; Fei B
  • Hyperspectral Imaging of Head and Neck Squamous Cell Carcinoma for Cancer Margin Detection in Surgical Specimens from 102 Patients Using Deep Learning.
    Cancers (Basel) Volume: 11
    09/14/2019 Authors: Halicek M; Dormer JD; Little JV; Chen AY; Myers L; Sumer BD; Fei B
  • Hyperspectral imaging for head and neck cancer detection: specular glare and variance of the tumor margin in surgical specimens.
    J Med Imaging (Bellingham) Volume: 6 Page(s): 035004
    07/01/2019 Authors: Halicek M; Fabelo H; Ortega S; Little JV; Wang X; Chen AY; Callico GM; Myers L; Sumer BD; Fei B
  • Optical biopsy of head and neck cancer using hyperspectral imaging and convolutional neural networks.
    J Biomed Opt Volume: 24 Page(s): 1 - 9
    03/01/2019 Authors: Halicek M; Little JV; Wang X; Chen AY; Fei B
  • Cancer Detection Using Hyperspectral Imaging and Evaluation of the Superficial Tumor Margin Variance with Depth.
    Proc SPIE Int Soc Opt Eng Volume: 10951
    02/01/2019 Authors: Halicek M; Fabelo H; Ortega S; Little JV; Wang X; Chen AY; Callico GM; Myers LL; Sumer BD; Fei B
  • Detection of Squamous Cell Carcinoma in Digitized Histological Images from the Head and Neck Using Convolutional Neural Networks.
    Proc SPIE Int Soc Opt Eng Volume: 10956
    02/01/2019 Authors: Halicek M; Shahedi M; Little JV; Chen AY; Myers LL; Sumer BD; Fei B
  • Pathologic Characteristics of Node-Positive Invasive Breast Carcinomas Associated With Extranodal Extension
    Volume: 150 Page(s): S53 - S53
    10/01/2018 Authors: Wade J; Little J; Zhang C; Chen Z; Meisel J; Hanley K
  • Tumor Margin Classification of Head and Neck Cancer Using Hyperspectral Imaging and Convolutional Neural Networks.
    Volume: 10576
    02/01/2018 Authors: Halicek M; Little JV; Wang X; Patel M; Griffith CC; Chen AY; Fei B
  • Deformable Registration of Histological Cancer Margins to Gross Hyperspectral Images using Demons.
    Proc SPIE Int Soc Opt Eng Volume: 10581
    02/01/2018 Authors: Halicek M; Little JV; Wang X; Chen ZG; Patel M; Griffith CC; El-Deiry MW; Saba NF; Chen AY; Fei B
  • Optical Biopsy of Head and Neck Cancer Using Hyperspectral Imaging and Convolutional Neural Networks.
    Proc SPIE Int Soc Opt Eng Volume: 10469
    01/01/2018 Authors: Halicek M; Little JV; Wang X; Patel M; Griffith CC; El-Deiry MW; Chen AY; Fei B
  • Detection of Head and Neck Cancer in Surgical Specimens Using Quantitative Hyperspectral Imaging.
    Clin Cancer Res Volume: 23 Page(s): 5426 - 5436
    09/15/2017 Authors: Lu G; Little JV; Wang X; Zhang H; Patel MR; Griffith CC; El-Deiry MW; Chen AY; Fei B
  • Label-free reflectance hyperspectral imaging for tumor margin assessment: a pilot study on surgical specimens of cancer patients.
    J Biomed Opt Volume: 22 Page(s): 1 - 7
    08/01/2017 Authors: Fei B; Lu G; Wang X; Zhang H; Little JV; Patel MR; Griffith CC; El-Diery MW; Chen AY
  • Label-free hyperspectral imaging and quantification methods for surgical margin assessment of tissue specimens of cancer patients.
    Annu Int Conf IEEE Eng Med Biol Soc Volume: 2017 Page(s): 4041 - 4045
    07/01/2017 Authors: Fei B; Guolan Lu; Halicek MT; Wang X; Zhang H; Little JV; Magliocca KR; Patel M; Griffith CC; El-Deiry MW
  • Deep convolutional neural networks for classifying head and neck cancer using hyperspectral imaging.
    J Biomed Opt Volume: 22 Page(s): 60503
    06/01/2017 Authors: Halicek M; Lu G; Little JV; Wang X; Patel M; Griffith CC; El-Deiry MW; Chen AY; Fei B
  • Tumor margin assessment of surgical tissue specimen of cancer patients using label-free hyperspectral imaging.
    Proc SPIE Int Soc Opt Eng Volume: 10054
    01/01/2017 Authors: Fei B; Lu G; Wang X; Zhang H; Little JV; Magliocca KR; Chen AY
  • Genital and perianal herpes simplex simulating neoplasia in patients with AIDS.
    AIDS Patient Care STDS Volume: 23 Page(s): 153 - 158
    03/01/2009 Authors: Mosunjac M; Park J; Wang W; Tadros T; Siddiqui M; Bagirov M; Little J
  • Short of breath, not short of diagnoses.
    J Hosp Med Volume: 4 Page(s): 60 - 67
    01/01/2009 Authors: Di Francesco L; Mora L; Leeper K; Doss M; Little J; Sheline M; Williams MV; Franco-Paredes C
  • Vascular "pseudo invasion" in laparoscopic hysterectomy specimens: a diagnostic pitfall.
    Am J Surg Pathol Volume: 32 Page(s): 560 - 565
    04/01/2008 Authors: Logani S; Herdman AV; Little JV; Moller KA
  • Cytomegalovirus cystitis with bladder wall dehiscence in a patient with AIDS.
    AIDS Volume: 22 Page(s): 795 - 796
    03/30/2008 Authors: Whitaker JA; Jacob JT; Little JV; DiazGranados CA
  • Syringomatous adenoma of the nipple--treatment by central mound resection and oncoplastic reconstruction.
    Breast J Volume: 14 Page(s): 102 - 105
    01/01/2008 Authors: Oliva VL; Little JV; Carlson GW
  • Genital and perianal herpes simplex simulating neoplasia in AIDS patients
    Volume: 21 Page(s): 287A - 287A
    01/01/2008 Authors: Mosunjac MB; Park J; Wang W; Tadros TS; Siddiqui MT; Sequeira JH; Little JV
  • Genital and perianal herpes simplex simulating neoplasia in AIDS patients
    Volume: 88 Page(s): 287A - 287A
    01/01/2008 Authors: Mosunjac MB; Park J; Wang W; Tadros TS; Siddiqui MT; Sequeira JH; Little JV
  • Clinicopathologic analysis of large and giant condyloma accuminata of the anus
    Volume: 21 Page(s): 119A - 119A
    01/01/2008 Authors: Friedman TM; Akinflorin J; Tadros TS; Altinel D; Tehrani M; Basturk O; Little JV; Tighiouart M; Adsay NV
  • Clinicopathologic analysis of large and giant condyloma accuminata of the anus
    Volume: 88 Page(s): 119A - 119A
    01/01/2008 Authors: Friedman TM; Akinflorin J; Tadros TS; Allinel D; Tehrani M; Basturk O; Little JV; Tighiouart M; Adsay NV
  • The utility of SMAD4 as a diagnostic immunohistochemical marker for pancreatic adenocarcinoma, and its expression in other solid tumors.
    Diagn Cytopathol Volume: 35 Page(s): 644 - 648
    10/01/2007 Authors: Ali S; Cohen C; Little JV; Sequeira JH; Mosunjac MB; Siddiqui MT
  • Utility of reflex Gomori methenamine silver staining for Pneumocystis jirovecii on bronchoalveolar lavage cytologic specimens: a review.
    Diagn Cytopathol Volume: 34 Page(s): 719 - 723
    11/01/2006 Authors: Nassar A; Zapata M; Little JV; Siddiqui MT
  • A comparative analysis of cytoplasmic mu (C mu) expression in acute lymphoblastic leukemia by molecular and immunologic techniques. Identification of leukemia cases expressing C mu mRNA transcripts in the absence of detectable C mu proteins.
    Am J Clin Pathol Volume: 97 Page(s): 885 - 892
    06/01/1992 Authors: Little JV; Foucar K; Duncan MH; Crago SS; McConnell TS; Griffith B; Chen IM; Vogler LB; Willman CL
  • How accelerated regulation will affect point-of-care testing.
    MLO Med Lab Obs Volume: 23 Page(s): 47 - 51
    01/01/1991 Authors: Krienitz D; Little J
  • Immunoreactivity of tumor-associated glycoprotein (TAG-72) in normal, hyperplastic, and neoplastic colon.
    Hum Pathol Volume: 20 Page(s): 994 - 1000
    10/01/1989 Authors: Listrom MB; Little JV; McKinley M; Fenoglio-Preiser CM
  • Flow cytometric analysis of lymphoma and lymphoma-like disorders.
    Semin Diagn Pathol Volume: 6 Page(s): 37 - 54
    02/01/1989 Authors: Little JV; Foucar K; Horvath A; Crago S
  • IMMUNOREACTIVITY OF TUMOR-ASSOCIATED GLYCOPROTEIN (TAG) IN NORMAL, HYPERPLASTIC, AND NEOPLASTIC COLON
    LABORATORY INVESTIGATION Volume: 60 Page(s): A54 - A54
    01/01/1989 Authors: LITTLE J; LISTROM M; MCKINLEY M; FENOGLIOPREISER C
  • PHENOTYPIC AND GENOTYPIC ANALYSIS OF A CASE OF PRIMARY CUTANEOUS LYMPHOBLASTIC LYMPHOMA
    MODERN PATHOLOGY Volume: 1 Page(s): A47 - A47
    01/01/1988 Authors: KERRIGAN D; LITTLE J; FOUCAR K; CRAGO S; WILLMAN C
  • IDENTIFICATION OF BCR ABL GENE REARRANGEMENTS IN JUVENILE PH'-NEGATIVE MYELODYSPLASIA, CML, AND MONOCYTIC LEUKEMIAS
    LABORATORY INVESTIGATION Volume: 58 Page(s): A56 - A56
    01/01/1988 Authors: LITTLE J; GRIFFITH B; FOUCAR K; PORTER P; WILLMAN C
  • IDENTIFICATION OF BCR/ABL GENE REARRANGEMENTS IN JUVENILE PH'-NEGATIVE MYELODYSPLASIA, CML, AND MONOCYTIC LEUKEMIAS
    MODERN PATHOLOGY Volume: 1 Page(s): A56 - A56
    01/01/1988 Authors: LITTLE J; GRIFFITH B; FOUCAR K; PORTER P; WILLMAN C
  • PHENOTYPIC AND GENOTYPIC ANALYSIS OF A CASE OF PRIMARY CUTANEOUS LYMPHOBLASTIC LYMPHOMA
    LABORATORY INVESTIGATION Volume: 58 Page(s): A47 - A47
    01/01/1988 Authors: KERRIGAN D; LITTLE J; FOUCAR K; CRAGO S; WILLMAN C
  • ANALYSIS OF CYTOPLASMIC MU EXPRESSION BY MOLECULAR AND IMMUNOLOGICAL TECHNIQUES
    MODERN PATHOLOGY Volume: 1 Page(s): A56 - A56
    01/01/1988 Authors: LITTLE J; GRIFFITH B; CRAGO S; VOGLER L; WILLMAN C
  • ANALYSIS OF CYTOPLASMIC MU EXPRESSION BY MOLECULAR AND IMMUNOLOGICAL TECHNIQUES
    LABORATORY INVESTIGATION Volume: 58 Page(s): A56 - A56
    01/01/1988 Authors: LITTLE J; GRIFFITH B; CRAGO S; VOGLER L; WILLMAN C
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