Publications

• Vadadustat Three Times Weekly in Patients With Anemia Due to Dialysis-Dependent CKD.
  Am J Kidney Dis Volume: 85 Page(s): 454 - 464.e1
  04/01/2025 Authors: Toka HR; Bernardo M; Burke SK; Luo W; Manllo-Karim R; Ullah I; Yang Z; Zhang Z; Tumlin J
• Efficacy and Safety of Ravulizumab in IgA Nephropathy: A Phase 2 Randomized Double-Blind Placebo-Controlled Trial.
  J Am Soc Nephrol Volume: 36 Page(s): 645 - 656
  04/01/2025 Authors: Lafayette R; Tumlin J; Fenoglio R; Kaufeld J; Prez Valdivia M; Wu M-S; Susan Huang S-H; Alamartine E; Kim SG; Yee M
• Effects of dialysate potassium concentration of 3.0mmol/l with sodium zirconium cyclosilicate ondialysis-free days versus dialysate potassiumconcentration of 2.0 mmol/l alone onrates of cardiac arrhythmias in hemodialysis patients with hyperkalemia.
  Kidney Int Volume: 107 Page(s): 169 - 179
  01/01/2025 Authors: Charytan DM; Winkelmayer WC; Granger CB; Middleton JP; Herzog CA; Chertow GM; Eudicone JM; Whitson JD; Tumlin JA; ADAPT Investigators
• Association of Dialysate Bicarbonate with Arrhythmia in the Monitoring in Dialysis Study.
  Kidney360 Volume: 5 Page(s): 1490 - 1499
  10/01/2024 Authors: Ravi KS; Tumlin JA; Roy-Chaudhury P; Koplan BA; Costea AI; Kher V; Williamson D; McClure CK; Charytan DM; Mc Causland FR
• Comparative Levels of Urinary Biomarkers of Renal Injury and Inflammation Among Patients With Diabetic Nephropathy With or Without Hyperuricemia.
  J Clin Rheumatol
  02/14/2024 Authors: Alex R; Press E; Sanchez L; Whitson J; Marder B; Tumlin JA
• Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis.
  N Engl J Med Volume: 389 Page(s): 2436 - 2445
  12/28/2023 Authors: Rheault MN; Alpers CE; Barratt J; Bieler S; Canetta P; Chae D-W; Coppock G; Diva U; Gesualdo L; Heerspink HJL
• Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial.
  Lancet Volume: 402 Page(s): 2077 - 2090
  12/02/2023 Authors: Rovin BH; Barratt J; Heerspink HJL; Alpers CE; Bieler S; Chae D-W; Diva UA; Floege J; Gesualdo L; Inrig JK
• Randomized Trial on the Effect of an Oral Spleen Tyrosine Kinase Inhibitor in the Treatment of IgA Nephropathy.
  Kidney Int Rep Volume: 8 Page(s): 2546 - 2556
  12/01/2023 Authors: Tam FWK; Tumlin J; Barratt J; Rovin BH; Roberts ISD; Roufosse C; Cook HT; Bhangal G; Brown AL; Busch M
• IgA nephropathy: the lectin pathway and implications for targeted therapy.
  Kidney Int Volume: 104 Page(s): 254 - 264
  08/01/2023 Authors: Barratt J; Lafayette RA; Zhang H; Tesar V; Rovin BH; Tumlin JA; Reich HN; Floege J
• Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial.
  Lancet Volume: 401 Page(s): 1584 - 1594
  05/13/2023 Authors: Heerspink HJL; Radhakrishnan J; Alpers CE; Barratt J; Bieler S; Diva U; Inrig J; Komers R; Mercer A; Noronha IL
• Association of Bradycardia and Asystole Episodes with Dialytic Parameters: An Analysis of the Monitoring in Dialysis (MiD) Study.
  Kidney360 Volume: 3 Page(s): 1871 - 1880
  11/24/2022 Authors: Soomro QH; Bansal N; Winkelmayer WC; Koplan BA; Costea AI; Roy-Chaudhury P; Tumlin JA; Kher V; Williamson DE; Pokhariyal S
• Erythropoietic effects of vadadustat in patients with anemia associated with chronic kidney disease.
  Am J Hematol Volume: 97 Page(s): 1178 - 1188
  09/01/2022 Authors: Koury MJ; Agarwal R; Chertow GM; Eckardt K-U; Fishbane S; Ganz T; Haase VH; Hanudel MR; Parfrey PS; Pergola PE
• Randomized Phase II JANUS Study of Atacicept in Patients With IgA Nephropathy and Persistent Proteinuria.
  Kidney Int Rep Volume: 7 Page(s): 1831 - 1841
  08/01/2022 Authors: Barratt J; Tumlin J; Suzuki Y; Kao A; Aydemir A; Pudota K; Jin H; Ghring H; Appel G; JANUS study investigators
• Clinical Outcomes of Patients with C3G or IC-MPGN Treated with the Factor D Inhibitor Danicopan: Final Results from Two Phase 2 Studies.
  Am J Nephrol Volume: 53 Page(s): 687 - 700
  01/01/2022 Authors: Nester C; Appel GB; Bomback AS; Bouman KP; Cook HT; Daina E; Dixon BP; Rice K; Najafian N; Hui J
• Baseline Clinical Characteristics and Complement Biomarkers of Patients with C3 Glomerulopathy Enrolled in Two Phase 2 Studies Investigating the Factor D Inhibitor Danicopan.
  Am J Nephrol Volume: 53 Page(s): 675 - 686
  01/01/2022 Authors: Podos SD; Trachtman H; Appel GB; Bomback AS; Dixon BP; Wetzels JFM; Cook HT; Parikh SV; Pickering MC; Tumlin J
• Vadadustat in Patients with Anemia and Non-Dialysis-Dependent CKD.
  N Engl J Med Volume: 384 Page(s): 1589 - 1600
  04/29/2021 Authors: Chertow GM; Pergola PE; Farag YMK; Agarwal R; Arnold S; Bako G; Block GA; Burke S; Castillo FP; Jardine AG
• Safety and Efficacy of Vadadustat for Anemia in Patients Undergoing Dialysis.
  N Engl J Med Volume: 384 Page(s): 1601 - 1612
  04/29/2021 Authors: Eckardt K-U; Agarwal R; Aswad A; Awad A; Block GA; Bacci MR; Farag YMK; Fishbane S; Hubert H; Jardine A
• Electrolyte Changes in Contemporary Hemodialysis: A Secondary Analysis of the Monitoring in Dialysis (MiD) Study.
  Kidney360 Volume: 2 Page(s): 695 - 707
  04/01/2021 Authors: Correa S; Scovner KM; Tumlin JA; Roy-Chaudhury P; Koplan BA; Costea AI; Kher V; Williamson D; Pokhariyal S; McClure CK
• Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection.
  Am J Med Volume: 134 Page(s): 16 - 22
  01/01/2021 Authors: McCullough PA; Kelly RJ; Ruocco G; Lerma E; Tumlin J; Wheelan KR; Katz N; Lepor NE; Vijay K; Carter H
• Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19).
  Rev Cardiovasc Med Volume: 21 Page(s): 517 - 530
  12/30/2020 Authors: McCullough PA; Alexander PE; Armstrong R; Arvinte C; Bain AF; Bartlett RP; Berkowitz RL; Berry AC; Borody TJ; Brewer JH
• Phase II, randomised, double-blind, multicentre study evaluating the safety and efficacy of filgotinib and lanraplenib in patients with lupus membranous nephropathy.
  RMD Open Volume: 6
  12/01/2020 Authors: Baker M; Chaichian Y; Genovese M; Derebail V; Rao P; Chatham W; Bubb M; Lim S; Hajian H; Gurtovaya O
• Renin and Survival in Patients Given Angiotensin II for Catecholamine-Resistant Vasodilatory Shock. A Clinical Trial.
  Am J Respir Crit Care Med Volume: 202 Page(s): 1253 - 1261
  11/01/2020 Authors: Bellomo R; Forni LG; Busse LW; McCurdy MT; Ham KR; Boldt DW; Hstbacka J; Khanna AK; Albertson TE; Tumlin J
• Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for Treatment of Anemia in Chronic Kidney Disease: A Placebo-Controlled Study of Pharmacokinetic and Pharmacodynamic Profiles in Hemodialysis Patients.
  J Clin Pharmacol Volume: 60 Page(s): 1432 - 1440
  11/01/2020 Authors: Provenzano R; Tumlin J; Zabaneh R; Chou J; Hemmerich S; Neff TB; Yu K-HP
• Intradialytic Hypotension and Cardiac Arrhythmias in Patients Undergoing Maintenance Hemodialysis: Results from the Monitoring in Dialysis Study.
  Clin J Am Soc Nephrol Volume: 15 Page(s): 805 - 812
  06/08/2020 Authors: Mc Causland FR; Tumlin JA; Roy-Chaudhury P; Koplan BA; Costea AI; Kher V; Williamson D; Pokhariyal S; Charytan DM; MiD Investigators and Committees*
• Urgent need for individual mobile phone and institutional reporting of at home, hospitalized, and intensive care unit cases of SARS-CoV-2 (COVID-19) infection.
  Rev Cardiovasc Med Volume: 21 Page(s): 1 - 7
  03/30/2020 Authors: McCullough PA; Eidt J; Rangaswami J; Lerma E; Tumlin J; Wheelan K; Katz N; Lepor NE; Vijay K; Soman S
• Relationship between dialytic parameters and reviewer confirmed arrhythmias in hemodialysis patients in the monitoring in dialysis study.
  BMC Nephrol Volume: 20 Page(s): 80
  03/05/2019 Authors: Tumlin JA; Roy-Chaudhury P; Koplan BA; Costea AI; Kher V; Williamson D; Pokhariyal S; Charytan DM; MiD investigators and Committees
• A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis.
  Kidney Int Volume: 95 Page(s): 219 - 231
  01/01/2019 Authors: Rovin BH; Solomons N; Pendergraft WF; Dooley MA; Tumlin J; Romero-Diaz J; Lysenko L; Navarra SV; Huizinga RB; AURA-LV Study Group
• JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: results from a Phase 2 randomized controlled clinical trial.
  Nephrol Dial Transplant Volume: 33 Page(s): 1950 - 1959
  11/01/2018 Authors: Tuttle KR; Brosius FC; Adler SG; Kretzler M; Mehta RL; Tumlin JA; Tanaka Y; Haneda M; Liu J; Silk ME
• Evaluation of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy After Single and Multiple Dosings of LY3016859 in Healthy Subjects and Patients With Diabetic Nephropathy.
  Clin Pharmacol Drug Dev Volume: 7 Page(s): 759 - 772
  09/01/2018 Authors: Sloan-Lancaster J; Raddad E; Deeg MA; Eli M; Flynt A; Tumlin J
• Effect of a Contrast Modulation Systemon Contrast Media Use and the Rate ofAcute Kidney Injury After Coronary Angiography.
  JACC Cardiovasc Interv Volume: 11 Page(s): 1601 - 1610
  08/27/2018 Authors: Mehran R; Faggioni M; Chandrasekhar J; Angiolillo DJ; Bertolet B; Jobe RL; Al-Joundi B; Brar S; Dangas G; Batchelor W
• Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II.
  Crit Care Med Volume: 46 Page(s): 949 - 957
  06/01/2018 Authors: Tumlin JA; Murugan R; Deane AM; Ostermann M; Busse LW; Ham KR; Kashani K; Szerlip HM; Prowle JR; Bihorac A
• Primary outcomes of the Monitoring in Dialysis Study indicate that clinically significant arrhythmias are common in hemodialysis patients and related to dialytic cycle.
  Kidney Int Volume: 93 Page(s): 941 - 951
  04/01/2018 Authors: Roy-Chaudhury P; Tumlin JA; Koplan BA; Costea AI; Kher V; Williamson D; Pokhariyal S; Charytan DM; MiD investigators and committees
• Protecting Podocytes: A Key Target for Therapy of Focal Segmental Glomerulosclerosis.
  Am J Nephrol Volume: 47 Suppl 1 Page(s): 14 - 29
  01/01/2018 Authors: Campbell KN; Tumlin JA
• Proteinuria in Nephrotic Syndrome: Mechanistic and Clinical Considerations in Optimizing Management.
  Am J Nephrol Volume: 47 Suppl 1 Page(s): 1 - 2
  01/01/2018 Authors: Tumlin JA; Campbell KN
• Angiotensin II for the Treatment of Vasodilatory Shock.
  N Engl J Med Volume: 377 Page(s): 419 - 430
  08/03/2017 Authors: Khanna A; English SW; Wang XS; Ham K; Tumlin J; Szerlip H; Busse LW; Altaweel L; Albertson TE; Mackey C
• A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction.
  J Am Soc Nephrol Volume: 28 Page(s): 1306 - 1313
  04/01/2017 Authors: Lafayette RA; Canetta PA; Rovin BH; Appel GB; Novak J; Nath KA; Sethi S; Tumlin JA; Mehta K; Hogan M
• A mechanistic investigation of thrombotic microangiopathy associated with IV abuse of Opana ER.
  Blood Volume: 129 Page(s): 896 - 905
  02/16/2017 Authors: Hunt R; Yalamanoglu A; Tumlin J; Schiller T; Baek JH; Wu A; Fogo AB; Yang H; Wong E; Miller P
• Arrhythmia and Sudden Death in Hemodialysis Patients: Protocol and Baseline Characteristics of the Monitoring in Dialysis Study.
  Clin J Am Soc Nephrol Volume: 11 Page(s): 721 - 734
  04/07/2016 Authors: Charytan DM; Foley R; McCullough PA; Rogers JD; Zimetbaum P; Herzog CA; Tumlin JA; MiD Investigators and Committees
• Major Adverse Events One Year After Acute Kidney Injury After Contrast-Enhanced Computed Tomography.
  Ann Emerg Med Volume: 66 Page(s): 267 - 274.e4
  09/01/2015 Authors: Mitchell AM; Kline JA; Jones AE; Tumlin JA
• Furosemide Stress Test and Biomarkers for the Prediction of AKI Severity.
  J Am Soc Nephrol Volume: 26 Page(s): 2023 - 2031
  08/01/2015 Authors: Koyner JL; Davison DL; Brasha-Mitchell E; Chalikonda DM; Arthur JM; Shaw AD; Tumlin JA; Trevino SA; Bennett MR; Kimmel PL
• A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device in Patients with Acute Kidney Injury.
  PLoS One Volume: 10 Page(s): e0132482
  01/01/2015 Authors: Tumlin JA; Galphin CM; Tolwani AJ; Chan MR; Vijayan A; Finkel K; Szamosfalvi B; Dev D; DaSilva JR; Astor BC
• Proposal for a functional classification system of heart failure in patients with end-stage renal disease: proceedings of the acute dialysis quality initiative (ADQI) XI workgroup.
  J Am Coll Cardiol Volume: 63 Page(s): 1246 - 1252
  04/08/2014 Authors: Chawla LS; Herzog CA; Costanzo MR; Tumlin J; Kellum JA; McCullough PA; Ronco C; ADQI XI Workgroup
• Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery.
  Kidney Int Volume: 85 Page(s): 431 - 438
  02/01/2014 Authors: Arthur JM; Hill EG; Alge JL; Lewis EC; Neely BA; Janech MG; Tumlin JA; Chawla LS; Shaw AD; SAKInet Investigators
• Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease.
  N Engl J Med Volume: 369 Page(s): 2492 - 2503
  12/26/2013 Authors: de Zeeuw D; Akizawa T; Audhya P; Bakris GL; Chin M; Christ-Schmidt H; Goldsberry A; Houser M; Krauth M; Lambers Heerspink HJ
• Association of elevated urinary concentration of renin-angiotensin system components and severe AKI.
  Clin J Am Soc Nephrol Volume: 8 Page(s): 2043 - 2052
  12/01/2013 Authors: Alge JL; Karakala N; Neely BA; Janech MG; Tumlin JA; Chawla LS; Shaw AD; Arthur JM; SAKInet Investigators
• Development and standardization of a furosemide stress test to predict the severity of acute kidney injury.
  Crit Care Volume: 17 Page(s): R207
  09/20/2013 Authors: Chawla LS; Davison DL; Brasha-Mitchell E; Koyner JL; Arthur JM; Shaw AD; Tumlin JA; Trevino SA; Kimmel PL; Seneff MG
• Randomized clinical trial of the iron-based phosphate binder PA21 in hemodialysis patients.
  Clin J Am Soc Nephrol Volume: 8 Page(s): 280 - 289
  02/01/2013 Authors: Wthrich RP; Chonchol M; Covic A; Gaillard S; Chong E; Tumlin JA
• Urinary angiotensinogen and risk of severe AKI.
  Clin J Am Soc Nephrol Volume: 8 Page(s): 184 - 193
  02/01/2013 Authors: Alge JL; Karakala N; Neely BA; Janech MG; Tumlin JA; Chawla LS; Shaw AD; Arthur JM; SAKInet Investigators
• The role of early and sufficient isolated venovenous ultrafiltration in heart failure patients with pulmonary and systemic congestion.
  Rev Cardiovasc Med Volume: 14 Page(s): e123 - e133
  01/01/2013 Authors: Costanzo MR; Chawla LS; Tumlin JA; Herzog CA; McCullough PA; Kellum JA; Ronco C
• Advanced diabetic nephropathy with nephrotic range proteinuria: a pilot study of the long-term efficacy of subcutaneous ACTH gel on proteinuria, progression of CKD, and urinary levels of VEGF and MCP-1.
  J Diabetes Res Volume: 2013 Page(s): 489869
  01/01/2013 Authors: Tumlin JA; Galphin CM; Rovin BH
• The effect of the selective cytopheretic device on acute kidney injury outcomes in the intensive care unit: a multicenter pilot study.
  Semin Dial Volume: 26 Page(s): 616 - 623
  01/01/2013 Authors: Tumlin JA; Chawla L; Tolwani AJ; Mehta R; Dillon J; Finkel KW; DaSilva JR; Astor BC; Yevzlin AS; Humes HD
• Pathophysiology of the cardiorenal syndromes: executive summary from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI).
  Volume: 182 Page(s): 82 - 98
  01/01/2013 Authors: McCullough PA; Kellum JA; Haase M; Mller C; Damman K; Murray PT; Cruz D; House AA; Schmidt-Ott KM; Vescovo G
• Cardiorenal syndrome type 4: insights on clinical presentation and pathophysiology from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI).
  Volume: 182 Page(s): 158 - 173
  01/01/2013 Authors: Tumlin JA; Costanzo MR; Chawla LS; Herzog CA; Kellum JA; McCullough PA; Ronco C
• Soluble urokinase receptor and focal segmental glomerulosclerosis.
  Curr Opin Nephrol Hypertens Volume: 21 Page(s): 428 - 432
  07/01/2012 Authors: Reiser J; Wei C; Tumlin J
• Prospective study of the incidence of contrast-induced nephropathy among patients evaluated for pulmonary embolism by contrast-enhanced computed tomography.
  Acad Emerg Med Volume: 19 Page(s): 618 - 625
  06/01/2012 Authors: Mitchell AM; Jones AE; Tumlin JA; Kline JA
• Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings.
  Clin J Am Soc Nephrol Volume: 7 Page(s): 856 - 860
  05/01/2012 Authors: Molitoris BA; Okusa MD; Palevsky PM; Chawla LS; Kaufman JS; Devarajan P; Toto RM; Hsu C-Y; Greene TH; Faubel SG
• Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology.
  Clin J Am Soc Nephrol Volume: 7 Page(s): 844 - 850
  05/01/2012 Authors: Palevsky PM; Molitoris BA; Okusa MD; Levin A; Waikar SS; Wald R; Chertow GM; Murray PT; Parikh CR; Shaw AD
• Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials.
  Clin J Am Soc Nephrol Volume: 7 Page(s): 851 - 855
  05/01/2012 Authors: Okusa MD; Molitoris BA; Palevsky PM; Chinchilli VM; Liu KD; Cheung AK; Weisbord SD; Faubel S; Kellum JA; Wald R
• Cell-based strategies for the treatment of kidney dysfunction: a review.
  Blood Purif Volume: 34 Page(s): 117 - 123
  01/01/2012 Authors: Pino CJ; Yevzlin AS; Tumlin J; Humes HD
• Immediate complications of intravenous contrast for computed tomography imaging in the outpatient setting are rare.
  Acad Emerg Med Volume: 18 Page(s): 1005 - 1009
  09/01/2011 Authors: Mitchell AM; Jones AE; Tumlin JA; Kline JA
• Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH) gel.
  Drug Des Devel Ther Volume: 5 Page(s): 147 - 153
  03/14/2011 Authors: Bomback AS; Tumlin JA; Baranski J; Bourdeau JE; Besarab A; Appel AS; Radhakrishnan J; Appel GB
• A longitudinal study of uremic pruritus in hemodialysis patients.
  Clin J Am Soc Nephrol Volume: 5 Page(s): 1410 - 1419
  08/01/2010 Authors: Mathur VS; Lindberg J; Germain M; Block G; Tumlin J; Smith M; Grewal M; McGuire D; ITCH National Registry Investigators
• A phase III, randomized, double-blind, placebo-controlled study of tenecteplase for improvement of hemodialysis catheter function: TROPICS 3.
  Clin J Am Soc Nephrol Volume: 5 Page(s): 631 - 636
  04/01/2010 Authors: Tumlin J; Goldman J; Spiegel DM; Roer D; Ntoso KA; Blaney M; Jacobs J; Gillespie BS; Begelman SM
• Incidence of contrast-induced nephropathy after contrast-enhanced computed tomography in the outpatient setting.
  Clin J Am Soc Nephrol Volume: 5 Page(s): 4 - 9
  01/01/2010 Authors: Mitchell AM; Jones AE; Tumlin JA; Kline JA
• Impaired blood flow in acute kidney injury: pathophysiology and potential efficacy of intrarenal vasodilator therapy.
  Curr Opin Crit Care Volume: 15 Page(s): 514 - 519
  12/01/2009 Authors: Tumlin JA
• Prostaglandin-based renal protection against contrast-induced acute kidney injury.
  Circulation Volume: 120 Page(s): 1749 - 1751
  11/03/2009 Authors: McCullough PA; Tumlin JA
• T-cell receptor-stimulated calcineurin activity is inhibited in isolated T cells from transplant patients.
  J Pharmacol Exp Ther Volume: 330 Page(s): 602 - 607
  08/01/2009 Authors: Tumlin JA; Roberts BR; Kokko KE; El Minshawy O; Gooch JL
• Abetimus sodium for renal flare in systemic lupus erythematosus: results of a randomized, controlled phase III trial.
  Arthritis Rheum Volume: 58 Page(s): 2470 - 2480
  08/01/2008 Authors: Cardiel MH; Tumlin JA; Furie RA; Wallace DJ; Joh T; Linnik MD; LJP 394-90-09 Investigator Consortium
• Systemic lupus international collaborating clinics renal activity/response exercise: development of a renal activity score and renal response index.
  Arthritis Rheum Volume: 58 Page(s): 1784 - 1788
  06/01/2008 Authors: Petri M; Kasitanon N; Lee S-S; Link K; Magder L; Bae S-C; Hanly JG; Isenberg DA; Nived O; Sturfelt G
• Systemic lupus international collaborating clinics renal activity/response exercise: comparison of agreement in rating renal response.
  Arthritis Rheum Volume: 58 Page(s): 1789 - 1795
  06/01/2008 Authors: Petri M; Kasitanon N; Singh S; Link K; Magder L; Bae S-C; Hanly JG; Nived O; Sturfelt G; van Vollenhoven R
• Efficacy and safety of renal tubule cell therapy for acute renal failure.
  J Am Soc Nephrol Volume: 19 Page(s): 1034 - 1040
  05/01/2008 Authors: Tumlin J; Wali R; Williams W; Murray P; Tolwani AJ; Vinnikova AK; Szerlip HM; Ye J; Paganini EP; Dworkin L
• Racial differences in the inhibition of calcineurin in stimulated T cells
  FASEB JOURNAL Volume: 22
  04/01/2008 Authors: Gooch JL; Roberts BR; Kokko KE; El Minshawy O; Tumlin JA
• Fenoldopam reduces the need for renal replacement therapy and in-hospital death in cardiovascular surgery: a meta-analysis.
  J Cardiothorac Vasc Anesth Volume: 22 Page(s): 27 - 33
  02/01/2008 Authors: Landoni G; Biondi-Zoccai GGL; Marino G; Bove T; Fochi O; Maj G; Calabr MG; Sheiban I; Tumlin JA; Ranucci M
• Contrast-induced nephropathy: is the picture any clearer?
  Clin J Am Soc Nephrol Volume: 3 Page(s): 261 - 262
  01/01/2008 Authors: Rudnick MR; Goldfarb S; Tumlin J
• Lupus nephritis: histology, diagnosis, and treatment.
  Volume: 66 Page(s): 188 - 194
  01/01/2008 Authors: Tumlin JA
• Idiopathic IgA nephropathy: pathogenesis, histopathology, and therapeutic options.
  Clin J Am Soc Nephrol Volume: 2 Page(s): 1054 - 1061
  09/01/2007 Authors: Tumlin JA; Madaio MP; Hennigar R
• Loss of the alpha-isoform of calcineurin is sufficient to induce nephrotoxicity and altered expression of transforming growth factor-beta.
  Transplantation Volume: 83 Page(s): 439 - 447
  02/27/2007 Authors: Gooch JL; Roberts BR; Cobbs SL; Tumlin JA
• Economic burden of contrast-induced nephropathy: implications for prevention strategies.
  J Med Econ Volume: 10 Page(s): 119 - 134
  01/01/2007 Authors: Subramanian S; Tumlin J; Bapat B; Zyczynski T
• Beneficial impact of fenoldopam in critically ill patients with or at risk for acute renal failure: a meta-analysis of randomized clinical trials.
  Am J Kidney Dis Volume: 49 Page(s): 56 - 68
  01/01/2007 Authors: Landoni G; Biondi-Zoccai GGL; Tumlin JA; Bove T; De Luca M; Calabr MG; Ranucci M; Zangrillo A
• Strategies to reduce the risk of contrast-induced nephropathy.
  Am J Cardiol Volume: 98 Page(s): 59K - 77K
  09/18/2006 Authors: Stacul F; Adam A; Becker CR; Davidson C; Lameire N; McCullough PA; Tumlin J; CIN Consensus Working Panel
• Baseline renal function screening.
  Am J Cardiol Volume: 98 Page(s): 21K - 26K
  09/18/2006 Authors: Lameire N; Adam A; Becker CR; Davidson C; McCullough PA; Stacul F; Tumlin J; CIN Consensus Working Panel
• High-risk situations and procedures.
  Am J Cardiol Volume: 98 Page(s): 37K - 41K
  09/18/2006 Authors: Becker CR; Davidson C; Lameire N; McCullough PA; Stacul F; Tumlin J; Adam A; CIN Consensus Working Panel
• Epidemiology and prognostic implications of contrast-induced nephropathy.
  Am J Cardiol Volume: 98 Page(s): 5K - 13K
  09/18/2006 Authors: McCullough PA; Adam A; Becker CR; Davidson C; Lameire N; Stacul F; Tumlin J; CIN Consensus Working Panel
• Risk prediction of contrast-induced nephropathy.
  Am J Cardiol Volume: 98 Page(s): 27K - 36K
  09/18/2006 Authors: McCullough PA; Adam A; Becker CR; Davidson C; Lameire N; Stacul F; Tumlin J; CIN Consensus Working Panel
• Pathophysiology of contrast-induced nephropathy.
  Am J Cardiol Volume: 98 Page(s): 14K - 20K
  09/18/2006 Authors: Tumlin J; Stacul F; Adam A; Becker CR; Davidson C; Lameire N; McCullough PA; CIN Consensus Working Panel
• Contrast medium use.
  Am J Cardiol Volume: 98 Page(s): 42K - 58K
  09/18/2006 Authors: Davidson C; Stacul F; McCullough PA; Tumlin J; Adam A; Lameire N; Becker CR; CIN Consensus Working Panel
• Contrast-Induced Nephropathy (CIN) Consensus Working Panel: executive summary.
  Rev Cardiovasc Med Volume: 7 Page(s): 177 - 197
  01/01/2006 Authors: McCullough PA; Stacul F; Becker CR; Adam A; Lameire N; Tumlin JA; Davidson CJ; CIN Consensus Working Panel
• A prospective, open-label trial of sirolimus in the treatment of focal segmental glomerulosclerosis.
  Clin J Am Soc Nephrol Volume: 1 Page(s): 109 - 116
  01/01/2006 Authors: Tumlin JA; Miller D; Near M; Selvaraj S; Hennigar R; Guasch A
• Primary prevention of acute renal failure in the critically ill.
  Curr Opin Crit Care Volume: 11 Page(s): 537 - 541
  12/01/2005 Authors: Kellum JA; Leblanc M; Gibney RTN; Tumlin J; Lieberthal W; Ronco C
• Risk factors for acute renal failure: inherent and modifiable risks.
  Curr Opin Crit Care Volume: 11 Page(s): 533 - 536
  12/01/2005 Authors: Leblanc M; Kellum JA; Gibney RTN; Lieberthal W; Tumlin J; Mehta R
• Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial.
  Am J Kidney Dis Volume: 46 Page(s): 26 - 34
  07/01/2005 Authors: Tumlin JA; Finkel KW; Murray PT; Samuels J; Cotsonis G; Shaw AD
• Relationship between anti-double-stranded DNA antibodies and exacerbation of renal disease in patients with systemic lupus erythematosus.
  Arthritis Rheum Volume: 52 Page(s): 1129 - 1137
  04/01/2005 Authors: Linnik MD; Hu JZ; Heilbrunn KR; Strand V; Hurley FL; Joh T; LJP 394 Investigator Consortium
• Clinical presentation, natural history, and treatment of crescentic proliferative IgA nephropathy.
  Semin Nephrol Volume: 24 Page(s): 256 - 268
  05/01/2004 Authors: Tumlin JA; Hennigar RA
• Calcineurin phosphatase activity: activation by glucocorticoids and role of intracellular calcium.
  Transplantation Volume: 77 Page(s): 259 - 267
  01/27/2004 Authors: Tong DC; Buck SM; Roberts BR; Klein JD; Tumlin JA
• LJP 394 (abetimus sodium, Riquent) in the management of systemic lupus erythematosus.
  Lupus Volume: 13 Page(s): 323 - 327
  01/01/2004 Authors: Wallace DJ; Tumlin JA
• FK-506 (tacrolimus)-resistance among African Americans: Blunted inhibition of calcineurin activity, interferon gamma and transforming growth factor beta production within activated CD4(+) T cells.
  Volume: 4 Page(s): 284 - 285
  01/01/2004 Authors: Tumlin J; Shakir M; Savage S; Roberts B
• Fenoldopam mesylate for the prevention of contrast-induced nephropathy: a randomized controlled trial.
  JAMA Volume: 290 Page(s): 2284 - 2291
  11/05/2003 Authors: Stone GW; McCullough PA; Tumlin JA; Lepor NE; Madyoon H; Murray P; Wang A; Chu AA; Schaer GL; Stevens M
• Efficacy of rapamycin in steroid-resistant, FK-506-Dependent FSGS: Stabilization of renal function and reduction in proteinuria.
  Volume: 14 Page(s): 524A - 524A
  11/01/2003 Authors: Tumlin JA; Miller DR; Guasch A
• Safety results from a RCT of LJP 394 in SLE patients with a history of renal disease.
  Volume: 14 Page(s): 449A - 449A
  11/01/2003 Authors: Wallace DJ; Cardiel MH; Tumlin JA; Furie R; Hura C; Strand V; Wang S; Yushmanova I; Heilbrunn KR
• FK-506 (tacrolimus)-resistance among African American patients: Reduced inhibition of calcineurin activity and interferon gamma production in activated peripheral lymphocytes
  Volume: 14 Page(s): 184A - 184A
  11/01/2003 Authors: Tumlin J; Shakir M; Roberts B
• Dopamine receptor 1 agonists in early acute tubular necrosis: A prospective, randomized, double blind, placebo-controlled trial of fenoldopam mesylate.
  Volume: 14 Page(s): 774A - 774A
  11/01/2003 Authors: Tumlin J; Finckle K; Murray P; Shaw A
• Crescentic, proliferative IgA nephropathy: clinical and histological response to methylprednisolone and intravenous cyclophosphamide.
  Nephrol Dial Transplant Volume: 18 Page(s): 1321 - 1329
  07/01/2003 Authors: Tumlin JA; Lohavichan V; Hennigar R
• Correlation between urinary ICAM-1 and severity of ARF in patients with post-operative ATN
  Volume: 17 Page(s): A846 - A846
  03/17/2003 Authors: Tumlin JA; El Bagdoudi DG; Irvine RF; Abbani R; Shakir M; Roberts BR
• LJP 394 for the prevention of renal flare in patients with systemic lupus erythematosus: results from a randomized, double-blind, placebo-controlled study.
  Arthritis Rheum Volume: 48 Page(s): 442 - 454
  02/01/2003 Authors: Alarcn-Segovia D; Tumlin JA; Furie RA; McKay JD; Cardiel MH; Strand V; Bagin RG; Linnik MD; Hepburn B; LJP 394 Investigator Consortium
• Improvement in health-related quality of life in systemic lupus erythematosus patients enrolled in a randomized clinical trial comparing LJP 394 treatment with placebo.
  Lupus Volume: 12 Page(s): 677 - 686
  01/01/2003 Authors: Strand V; Aranow C; Cardiel MH; Alarcn-Segovia D; Furie R; Sherrer Y; Tumlin J; Wallace DJ; Crawford B; LJP 394 Investigator Consortium
• Dexamethasone-induced activation of calcineurin involves rapid tyrosine phosphorylation of PLC gamma-1, and gamma-2 isoforms of insositol tri-phosphate
  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 13 Page(s): 503A - 503A
  09/01/2002 Authors: Tong DC; Roberts BR; Abbani LR; Tumlin JA
• Eicosapentanoic acid (EPA fish oil) reduces platelet deposition in dialyis AV grafts: A randomized, double-blind, placebo-controlled trial.
  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 13 Page(s): 34A - 34A
  09/01/2002 Authors: Tumlin J; Roberts B; Crymes J; Wheeler A; Someren J; Halkar R
• Angiotensin II stimulates calcineurin activity in proximal tubule epithelia through AT-1 receptor-mediated tyrosine phosphorylation of the PLC-gamma1 isoform.
  J Am Soc Nephrol Volume: 13 Page(s): 1750 - 1756
  07/01/2002 Authors: Lea JP; Jin SG; Roberts BR; Shuler MS; Marrero MB; Tumlin JA
• SLE trial shows fewer renal flares in LJP 394-treated patients with high-affinity antibodies to LJP 394.
  Volume: 103 Page(s): S87 - S87
  06/01/2002 Authors: Alarcon-Segovia D; Tumlin J; Furie R; McKay J; Cardiel M; Strand V; Linnik M; Hepburn B
• Fenoldopam mesylate blocks reductions in renal plasma flow after radiocontrast dye infusion: a pilot trial in the prevention of contrast nephropathy.
  Am Heart J Volume: 143 Page(s): 894 - 903
  05/01/2002 Authors: Tumlin JA; Wang A; Murray PT; Mathur VS
• Glucocorticoids stimulate calcineurin in Jurkat T cells through a non genomic pathway
  FASEB JOURNAL Volume: 16 Page(s): A902 - A902
  03/22/2002 Authors: Tumlin J; Roberts B; Tong D
• Design and rationale of CONTRAST--a prospective, randomized, placebo-controlled trial of fenoldopam mesylate for the prevention of radiocontrast nephropathy.
  Rev Cardiovasc Med Volume: 2 Suppl 1 Page(s): S31 - S36
  01/01/2001 Authors: Stone GW; Tumlin JA; Madyoon H; Lepor NE; McCullough PA; Mathur VS; Murray PT; O'Neill WW
• SLE trial shows fewer renal flares in LJP 394-treated patients with high-affinity antibodies to LJP 394. 90-05 trial results.
  Volume: 43 Page(s): S272 - S272
  09/01/2000 Authors: Alarcon-Segovia D; Tumlin J; Furie R; McKay J; Cardiel M; Linnik M; Hepburn B
• Fenoldopam, a dopamine agonist, for hypertensive emergency: a multicenter randomized trial. Fenoldopam Study Group.
  Acad Emerg Med Volume: 7 Page(s): 653 - 662
  06/01/2000 Authors: Tumlin JA; Dunbar LM; Oparil S; Buckalew V; Ram CV; Mathur V; Ellis D; McGuire D; Fellmann J; Luther RR
• Heat shock proteins 70 and 90 increase calcineurin activity in vitro through calmodulin-dependent and independent mechanisms.
  Biochem Biophys Res Commun Volume: 260 Page(s): 619 - 625
  07/14/1999 Authors: Someren JS; Faber LE; Klein JD; Tumlin JA
• Lupus nephritis: novel immunosuppressive modalities and future directions.
  Semin Nephrol Volume: 19 Page(s): 67 - 76
  01/01/1999 Authors: Tumlin JA
• Dexamethasone activates calcineurin activity in LLCPK-1 cells transfected with the glucocorticoid receptor through a mechanism involving receptor-associated HSP-90.
  Volume: 12 Page(s): A451 - A451
  03/17/1998 Authors: Tumlin JA; Smith C
• Dexamethasone activates calcineurin phosphatase activity in LLCPK-1 cells transfected with the glucocorticoid receptor through a mechanism involving receptor-associated HSP-90.
  JOURNAL OF INVESTIGATIVE MEDICINE Volume: 46 Page(s): 63A - 63A
  01/01/1998 Authors: Tumlin JA; Smith C; Edge S; Someren JT
• Expression and function of calcineurin in the mammalian nephron: physiological roles, receptor signaling, and ion transport.
  Am J Kidney Dis Volume: 30 Page(s): 884 - 895
  12/01/1997 Authors: Tumlin JA
• Angiotensin-II activates calcineurin phosphatase activity in LLCPK-1 cells through phospholipase C and tyrosine kinase dependent pathways.
  Volume: 8 Page(s): A2082 - A2082
  09/01/1997 Authors: Tumlin JA; Smith C; Lea JP
• Heat shock protein-90 mediates dexamethasone-induced stimulation of calcineurin activity in LLCPK-1 cells transfected with glucocorticoid receptors.
  Volume: 8 Page(s): A1892 - A1892
  09/01/1997 Authors: Tumlin JA; Smith C; Lea JP
• Aldosterone and dexamethasone stimulate calcineurin activity through a transcription-independent mechanism involving steroid receptor-associated heat shock proteins.
  J Clin Invest Volume: 99 Page(s): 1217 - 1223
  03/15/1997 Authors: Tumlin JA; Lea JP; Swanson CE; Smith CL; Edge SS; Someren JS
• Heat shock proteins associated with steroid receptor complexes increase calcineurin activity in vitro.
  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 7 Page(s): A2198 - A2198
  09/01/1996 Authors: Someren JT; Smith C; Tai PK; Faber L; Tumlin JA
• Dose dependent stimulation of in-vitro calcineurin activity by HSP-90 and HSP-70: Role of calmodulin.
  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 7 Page(s): A2208 - A2208
  09/01/1996 Authors: Tumlin JA; Smith C; Eaton DC; Tai PK; Someren JT
• Case report: delayed hypercalcemia after rhabdomyolysis-induced acute renal failure.
  Am J Med Sci Volume: 311 Page(s): 186 - 188
  04/01/1996 Authors: Sperling LS; Tumlin JA
• Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron.
  Am J Physiol Volume: 269 Page(s): F558 - F563
  10/01/1995 Authors: Tumlin JA; Someren JT; Swanson CE; Lea JP
• ALDOSTERONE-INDUCED STIMULATION OF CALCINEURIN ACTIVITY IN RAT CCD INVOLVES CALMODULIN AND FKBP-59
  Volume: 6 Page(s): 812 - 812
  09/01/1995 Authors: SOMEREN JS; LEA JP; SWANSON CE; TUMLIN JA
• EVIDENCE THAT THE ANGIOTENSIN-II RECEPTOR (AT(1)) SIGNALING IN THE RAT NEPHRON OCCURS INDEPENDENTLY OF PHOSPHOLIPASE-C BETA-SUBUNIT ISOFORMS
  Volume: 6 Page(s): 798 - 798
  09/01/1995 Authors: LEA JP; MARRERO MB; BERNSTEIN KE; TUMLIN JA
• ALDOSTERONE REGULATES CALCINEURIN PROTEIN EXPRESSION IN RAT CORTICAL COLLECTING DUCT
  FASEB JOURNAL Volume: 9 Page(s): A564 - A564
  03/09/1995 Authors: LEA JP; SOMEREN JT; SANDS JM; TUMLIN JA
• Sodium-dependent net urea transport in rat initial inner medullary collecting ducts.
  J Clin Invest Volume: 94 Page(s): 1513 - 1517
  10/01/1994 Authors: Isozaki T; Lea JP; Tumlin JA; Sands JM
• CALCINEURIN ACTIVITY AND EXPRESSION OF ITS ALPHA-ISOFORM AND BETA-ISOFORM PROTEINS ARE HETEROGENEOUS ALONG THE RAT NEPHRON
  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 5 Page(s): 721 - 721
  09/01/1994 Authors: LEA JP; SANDS JM; TUMLIN JA
• ALDOSTERONE STIMULATES CALCINEURIN ACTIVITY IN RAT DISTAL NEPHRON SEGMENTS
  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 5 Page(s): 734 - 734
  09/01/1994 Authors: TUMLIN JA; SANDS JM; LEA JP
• Evidence that the inhibition of Na+/K(+)-ATPase activity by FK506 involves calcineurin.
  Kidney Int Volume: 46 Page(s): 647 - 652
  09/01/1994 Authors: Lea JP; Sands JM; McMahon SJ; Tumlin JA
• SPECIFIC CELL BIOLOGIC RESPONSES CORRESPONDING TO THE CHANGES IN URINE CONCENTRATION ASSOCIATED WITH A LOW-PROTEIN DIET
  CLINICAL RESEARCH Volume: 42 Page(s): A264 - A264
  04/01/1994 Authors: SANDS JM; ISOZAKI T; GILLIN AG; LEA JP; SWANSON CE; TUMLIN JA
• CALCINEURIN ACTIVITY IN THE RAT NEPHRON - ROLE IN SEGMENT-SPECIFIC INHIBITION OF NA/K-ATPASE BY FK-506
  CLINICAL RESEARCH Volume: 42 Page(s): A261 - A261
  04/01/1994 Authors: TUMLIN JA; LEA JP; SANDS JM
• Expression of Na-K-ATPase alpha- and beta-subunit mRNA and protein isoforms in the rat nephron.
  Am J Physiol Volume: 266 Page(s): F240 - F245
  02/01/1994 Authors: Tumlin JA; Hoban CA; Medford RM; Sands JM
• SEGMENT-SPECIFIC EXPRESSION OF NA+/K+-ATPASE ALPHA-ISOFORMS AND BETA-ISOFORMS DOES NOT EXPLAIN CYCLOSPORINE-A-INDUCED NA PUMP INHIBITION
  CLINICAL RESEARCH Volume: 41 Page(s): A141 - A141
  04/01/1993 Authors: TUMLIN JA; SANDS JM
• A POTENTIAL MECHANISM FOR HYPERKALEMIA WITH IMMUNOSUPPRESSIVE THERAPY - COMPARISON OF CHANGES IN NA+/K+-ATPASE ACTIVITY WITH CYCLOSPORINE-A AND FK506
  CLINICAL RESEARCH Volume: 41 Page(s): A326 - A326
  04/01/1993 Authors: LEA JP; SANDS JM; TUMLIN JA
• Nephron segment-specific inhibition of Na+/K(+)-ATPase activity by cyclosporin A.
  Kidney Int Volume: 43 Page(s): 246 - 251
  01/01/1993 Authors: Tumlin JA; Sands JM
• POTENTIAL MECHANISM FOR CYCLOSPORINE-INDUCED HYPERKALEMIA - CYCLOSPORINE-A INHIBITS NA/K ATPASE ACTIVITY IN NEPHRON SEGMENTS IMPORTANT TO POTASSIUM SECRETION
  CLINICAL RESEARCH Volume: 40 Page(s): A178 - A178
  04/01/1992 Authors: TUMLIN JA; SANDS JM
• Hemolytic-uremic syndrome following "crack" cocaine inhalation.
  Am J Med Sci Volume: 299 Page(s): 366 - 371
  06/01/1990 Authors: Tumlin JA; Sands JM; Someren A