Publications

• Immune checkpoint blockade resistance in lung cancer: emerging mechanisms and therapeutic opportunities.
  Trends Pharmacol Sci Volume: 45 Page(s): 520 - 536
  06/01/2024 Authors: Konen JM; Wu H; Gibbons DL
• Directions to overcome therapy resistance in cancer.
  Trends Pharmacol Sci Volume: 45 Page(s): 467 - 471
  06/01/2024 Authors: Nussinov R; Weichhart T; Dlamini Z; Gibbons DL; Van Seuningen I; Konen J; Ju H-Q
• Autotaxin suppresses cytotoxic T cells via LPAR5 to promote anti-PD-1 resistance in non-small cell lung cancer.
  J Clin Invest Volume: 133
  09/01/2023 Authors: Konen JM; Rodriguez BL; Wu H; Fradette JJ; Gibson L; Diao L; Wang J; Schmidt S; Wistuba II; Zhang J
• A live-cell platform to isolate phenotypically defined subpopulations for spatial multi-omic profiling.
  bioRxiv
  03/01/2023 Authors: Khatib TO; Amanso AM; Pedro B; Knippler CM; Summerbell ER; Zohbi NM; Konen JM; Mouw JK; Marcus AI
• A live-cell platform to isolate phenotypically defined subpopulations for spatial multi-omic profiling.
  PLoS One Volume: 18 Page(s): e0292554
  01/01/2023 Authors: Khatib TO; Amanso AM; Knippler CM; Pedro B; Summerbell ER; Zohbi NM; Konen JM; Mouw JK; Marcus AI
• Prognostic significance of an invasive leader cell-derived mutation cluster on chromosome 16q.
  Cancer Volume: 126 Page(s): 3140 - 3150
  07/01/2020 Authors: Pedro B; Rupji M; Dwivedi B; Kowalski J; Konen JM; Owonikoko TK; Ramalingam SS; Vertino PM; Marcus AI
• Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning.
  Sci Adv Volume: 6 Page(s): eaaz6197
  07/01/2020 Authors: Summerbell ER; Mouw JK; Bell JSK; Knippler CM; Pedro B; Arnst JL; Khatib TO; Commander R; Barwick BG; Konen J
• Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion.
  Nat Commun Volume: 11 Page(s): 1533
  03/24/2020 Authors: Commander R; Wei C; Sharma A; Mouw JK; Burton LJ; Summerbell E; Mahboubi D; Peterson RJ; Konen J; Zhou W
• Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes.
  J Cell Sci Volume: 132
  10/09/2019 Authors: Zoeller EL; Pedro B; Konen J; Dwivedi B; Rupji M; Sundararaman N; Wang L; Horton JR; Zhong C; Barwick BG
• Dissecting the biology of leader and follower cells in collective cancer invasion
  Volume: 79
  07/01/2019 Authors: Pedro BA; Konen J; Summerbell E; Mouw JK; Rupji M; Dwivedi B; Kowalski J; Vertino PM; Marcus AI
• MY01.0 aberrant methylation and overexpression in lung cancer leader cells drives the formation of long filopodia that regulate fibronectin architecture and collective invasion
  Volume: 29 Page(s): 232 - 233
  12/15/2018 Authors: Summerbell ER; Konen J; Kowalski J; Vertino PM; Marcus AI
• TASI: A software tool for spatial-temporal quantification of tumor spheroid dynamics.
  Sci Rep Volume: 8 Page(s): 7248
  05/08/2018 Authors: Hou Y; Konen J; Brat DJ; Marcus AI; Cooper LAD
• The complex ecosystem in non small cell lung cancer invasion.
  PLoS Comput Biol Volume: 14 Page(s): e1006131
  05/01/2018 Authors: Haney S; Konen J; Marcus AI; Bazhenov M
• Vimentin Is Required for Lung Adenocarcinoma Metastasis via Heterotypic Tumor Cell-Cancer-Associated Fibroblast Interactions during Collective Invasion.
  Clin Cancer Res Volume: 24 Page(s): 420 - 432
  01/15/2018 Authors: Richardson AM; Havel LS; Koyen AE; Konen JM; Shupe J; Wiles WG; Martin WD; Grossniklaus HE; Sica G; Gilbert-Ross M
• Using an image-guided genomics platform to probe the phenotypic heterogenetiy of collective cancer invasion
  Volume: 34 Page(s): 491 - 491
  12/01/2017 Authors: Konen J; Summerbell E; Vertino P; Marcus A
• Regulation of invasion by lysine demethylase 5B in non-small cell lung cancer cells
  Volume: 77
  07/01/2017 Authors: Zoeller EL; Konen J; Bell J; Summerbell E; Kowalski J; Marcus A; Vertino P
• Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion.
  Nat Commun Volume: 8 Page(s): 15078
  05/12/2017 Authors: Konen J; Summerbell E; Dwivedi B; Galior K; Hou Y; Rusnak L; Chen A; Saltz J; Zhou W; Boise LH
• Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma.
  JCI Insight Volume: 2 Page(s): e90487
  03/09/2017 Authors: Gilbert-Ross M; Konen J; Koo J; Shupe J; Robinson BS; Wiles WG; Huang C; Martin WD; Behera M; Smith GH
• Local alignment vectors reveal cancer cell-induced ECM fiber remodeling dynamics.
  Sci Rep Volume: 7 Page(s): 39498
  01/03/2017 Authors: Lee B; Konen J; Wilkinson S; Marcus AI; Jiang Y
• Leader cells are defined by DNA hypermethylation and aberrant gene expression during collective lung cancer invasion.
  Volume: 28
  01/01/2017 Authors: Summerbell ER; Bell J; Konen J; Kowalski J; Vertino PM; Marcus AI
• Leader cells are defined by DNA hypermethylation and aberrant gene expression during collective lung cancer invasion.
  Volume: 28
  01/01/2017 Authors: Summerbell ER; Bell J; Konen J; Kowalski J; Vertino PM; Marcus AI
• Developing a personalized anti-metastatic therapy to treat KRAS, LKB1-mutant lung adenocarcinoma
  Volume: 76
  07/01/2016 Authors: Gilbert-Ross M; Konen J; Koo J; Shupe J; Sica GL; Chen Z; Robinson BS; Behera M; Rossi MR; Smith GH
• LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.
  Mol Biol Cell Volume: 27 Page(s): 1069 - 1084
  04/01/2016 Authors: Konen J; Wilkinson S; Lee B; Fu H; Zhou W; Jiang Y; Marcus AI
• An early treatment window to target FAK-dependent collective invasion in Lkb1-mutant lung adenocarcinoma
  Volume: 76
  04/01/2016 Authors: Gilbert-Ross M; Konen J; Shupe J; Koo J; Sica GL; Ramalingam SS; Fu H; Khuri FR; Zhou W; Marcus AI
• Cell-cell cooperativity modulates proliferation and mitotic defects of phenotypically heterogeneous invading cancer cells.
  MOLECULAR BIOLOGY OF THE CELL Volume: 27
  01/01/2016 Authors: Summerbell E; Konen J; Marcus AI
• Defining the invasive biology of clinically relevant LKB1 mutations in lung cancer.
  MOLECULAR BIOLOGY OF THE CELL Volume: 27
  01/01/2016 Authors: Commander R; Hou Y; Konen J; Wilkinson S; Gilbert-Ross M; Cooper L; Marcus AI
• Identifying genomic signatures of rare cancer cells within a heterogeneous collective invasive pack.
  Volume: 27
  01/01/2016 Authors: Pedro B; Konen J; Summerbell E; Li W; Dwivedi B; Kowalski J; Vertino PM; Marcus AI
• Cell-cell cooperativity modulates proliferation and mitotic defects of phenotypically heterogeneous invading cancer cells.
  Volume: 27
  01/01/2016 Authors: Summerbell E; Konen J; Marcus AI
• Attacking the SAGA of tumor heterogeneity: The development of a novel technique to provide spatiotemporal genomic profiling of rare cancer cells
  Volume: 75
  11/15/2015 Authors: Konen J; Marcus AI
• LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to create a uniquely invasive amoeboid cancer cell
  MOLECULAR BIOLOGY OF THE CELL Volume: 26
  01/01/2015 Authors: Wilkinson S; Konen JM; Marcus A
• A novel image-guided genomics approach to dissect the mechanisms of collective cancer cell invasion.
  MOLECULAR BIOLOGY OF THE CELL Volume: 26
  01/01/2015 Authors: Konen JM; Marcus A