Jennifer Spangle
- Department of Radiation Oncology
Assistant Professor
- (404) 778-6173
- jennifer.spangle@emory.edu
- Spangle Lab
Overview
Jennifer M. Spangle, PhD, joined the Department of Radiation Oncology at Emory University School of Medicine in August 2019 as Assistant Professor. Prior to joining Emory, Dr. Spangle was Instructor of Pathology at Dana-Farber Cancer Institute and Harvard Medical School.
Dr. Spangle graduated with honors from the University of Arizona with a BS in Molecular and Cellular Biology. She earned her PhD in Virology from Harvard Medical School in Boston, Massachusetts. She completed her postdoctoral training at Dana-Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts, where she was the American Cancer Society Lee Denim Postdoctoral Fellow.
Academic Appointment
- Assistant Professor, Department of Radiation Oncology, Emory University School of Medicine
Education
Degrees
- PhD from Harvard University
Research
Focus
-
Unlocking novel therapies through the PI3K pathway
The Spangle laboratory is committed to understanding how PI3K-mediated regulation of the epigenome contributes to cancer development and modulates treatment response. The PI3K signaling pathways is aberrantly activated in more than 40% of breast and other cancers, and yet mono- and combination therapies resulting in durable PI3K inhibition are still in development. Her research program hopes to utilize PI3K-mediated epigenetic rewiring to identify actionable targets and durable and efficacious combination therapies for the treatment of PI3K-activated cancers. The Spangle lab is specifically focusing on the mechanisms by which H3K4-directed demethylases and methyltransferases mediate resistance to PI3K inhibitors in cancer and how AKT regulates histone phosphorylation and transcriptional competence in normal tissue and how this process is deregulated in cancer.
Publications
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Dynamic In Vivo Mapping of the Methylproteome Using a Chemoenzymatic Approach.
J Am Chem Soc Volume: 147 Page(s): 7214 - 7230
03/05/2025 Authors: Farhi J; Emenike B; Lee RS; Sad K; Fawwal DV; Beusch CM; Jones RB; Verma AK; Jones CY; Foroozani M -
Histone H3E50K remodels chromatin to confer oncogenic activity and support an EMT phenotype.
NAR Cancer Volume: 7 Page(s): zcaf002
03/01/2025 Authors: Sad K; Fawwal DV; Jones CY; Hill EJ; Skinner KT; Adams ML; Lustenberger S; Lee RS; Lohano SV; Elayavalli SR -
Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotype.
bioRxiv
08/01/2024 Authors: Sad K; Jones CY; Fawwal DV; Hill EJ; Skinner K; Lustenberger S; Lee RS; Elayavalli SR; Farhi J; Lemon LD -
Tertiary Amine Coupling by Oxidation for Selective Labeling of Dimethyl Lysine Post-Translational Modifications.
J Am Chem Soc Volume: 146 Page(s): 10621 - 10631
04/17/2024 Authors: Emenike B; Czabala P; Farhi J; Swaminathan J; Anslyn EV; Spangle J; Raj M -
Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.
Commun Biol Volume: 7 Page(s): 426
04/08/2024 Authors: Mittal K; Cooper GW; Lee BP; Su Y; Skinner KT; Shim J; Jonus HC; Kim WJ; Doshi M; Almanza D -
Exploring the Molecular Underpinnings of Cancer-Causing Oncohistone Mutants Using Yeast as a Model.
J Fungi (Basel) Volume: 9
12/11/2023 Authors: Zhang X; Fawwal DV; Spangle JM; Corbett AH; Jones CY -
Chemical sensors for imaging total cellular aliphatic aldehydes in live cells.
Chem Sci Volume: 14 Page(s): 8305 - 8314
08/09/2023 Authors: Wills R; Farhi J; Czabala P; Shahin S; M Spangle J; Raj M -
Emerging Role of Epigenetic Modifiers in Breast Cancer Pathogenesis and Therapeutic Response.
Cancers (Basel) Volume: 15
08/07/2023 Authors: Lee RS; Sad K; Fawwal DV; Spangle JM -
Identification of ligand-receptor pairs that drive human astrocyte development.
Nat Neurosci Volume: 26 Page(s): 1339 - 1351
08/01/2023 Authors: Voss AJ; Lanjewar SN; Sampson MM; King A; Hill EJ; Sing A; Sojka C; Bhatia TN; Spangle JM; Sloan SA -
Targeting MLL Methyltransferases Enhances the Antitumor Effects of PI3K Inhibition in Hormone Receptor-positive Breast Cancer.
Cancer Res Commun Volume: 2 Page(s): 1569 - 1578
12/01/2022 Authors: Jones RB; Farhi J; Adams M; Parwani KK; Cooper GW; Zecevic M; Lee RS; Hong AL; Spangle JM