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Profile

Jennifer Spangle

  • Department of Radiation Oncology
    Assistant Professor
  • (404) 778-6173
  • jennifer.spangle@emory.edu
  • Spangle Lab
Head shot of Jennifer Spangle

Overview

Jennifer M. Spangle, PhD, joined the Department of Radiation Oncology at Emory University School of Medicine in August 2019 as Assistant Professor. Prior to joining Emory, Dr. Spangle was Instructor of Pathology at Dana-Farber Cancer Institute and Harvard Medical School.

Dr. Spangle graduated with honors from the University of Arizona with a BS in Molecular and Cellular Biology. She earned her PhD in Virology from Harvard Medical School in Boston, Massachusetts. She completed her postdoctoral training at Dana-Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts, where she was the American Cancer Society Lee Denim Postdoctoral Fellow.

Academic Appointment

  • Assistant Professor, Department of Radiation Oncology, Emory University School of Medicine

Education

Degrees

  • PhD from Harvard University

Research

Focus

  • Unlocking novel therapies through the PI3K pathway

    The Spangle laboratory is committed to understanding how PI3K-mediated regulation of the epigenome contributes to cancer development and modulates treatment response. The PI3K signaling pathways is aberrantly activated in more than 40% of breast and other cancers, and yet mono- and combination therapies resulting in durable PI3K inhibition are still in development. Her research program hopes to utilize PI3K-mediated epigenetic rewiring to identify actionable targets and durable and efficacious combination therapies for the treatment of PI3K-activated cancers. The Spangle lab is specifically focusing on the mechanisms by which H3K4-directed demethylases and methyltransferases mediate resistance to PI3K inhibitors in cancer and how AKT regulates histone phosphorylation and transcriptional competence in normal tissue and how this process is deregulated in cancer.

Publications

  • Dynamic In Vivo Mapping of the Methylproteome Using a Chemoenzymatic Approach.
    J Am Chem Soc Volume: 147 Page(s): 7214 - 7230
    03/05/2025 Authors: Farhi J; Emenike B; Lee RS; Sad K; Fawwal DV; Beusch CM; Jones RB; Verma AK; Jones CY; Foroozani M
  • Histone H3E50K remodels chromatin to confer oncogenic activity and support an EMT phenotype.
    NAR Cancer Volume: 7 Page(s): zcaf002
    03/01/2025 Authors: Sad K; Fawwal DV; Jones CY; Hill EJ; Skinner KT; Adams ML; Lustenberger S; Lee RS; Lohano SV; Elayavalli SR
  • Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotype.
    bioRxiv
    08/01/2024 Authors: Sad K; Jones CY; Fawwal DV; Hill EJ; Skinner K; Lustenberger S; Lee RS; Elayavalli SR; Farhi J; Lemon LD
  • Tertiary Amine Coupling by Oxidation for Selective Labeling of Dimethyl Lysine Post-Translational Modifications.
    J Am Chem Soc Volume: 146 Page(s): 10621 - 10631
    04/17/2024 Authors: Emenike B; Czabala P; Farhi J; Swaminathan J; Anslyn EV; Spangle J; Raj M
  • Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.
    Commun Biol Volume: 7 Page(s): 426
    04/08/2024 Authors: Mittal K; Cooper GW; Lee BP; Su Y; Skinner KT; Shim J; Jonus HC; Kim WJ; Doshi M; Almanza D
  • Exploring the Molecular Underpinnings of Cancer-Causing Oncohistone Mutants Using Yeast as a Model.
    J Fungi (Basel) Volume: 9
    12/11/2023 Authors: Zhang X; Fawwal DV; Spangle JM; Corbett AH; Jones CY
  • Chemical sensors for imaging total cellular aliphatic aldehydes in live cells.
    Chem Sci Volume: 14 Page(s): 8305 - 8314
    08/09/2023 Authors: Wills R; Farhi J; Czabala P; Shahin S; M Spangle J; Raj M
  • Emerging Role of Epigenetic Modifiers in Breast Cancer Pathogenesis and Therapeutic Response.
    Cancers (Basel) Volume: 15
    08/07/2023 Authors: Lee RS; Sad K; Fawwal DV; Spangle JM
  • Identification of ligand-receptor pairs that drive human astrocyte development.
    Nat Neurosci Volume: 26 Page(s): 1339 - 1351
    08/01/2023 Authors: Voss AJ; Lanjewar SN; Sampson MM; King A; Hill EJ; Sing A; Sojka C; Bhatia TN; Spangle JM; Sloan SA
  • Targeting MLL Methyltransferases Enhances the Antitumor Effects of PI3K Inhibition in Hormone Receptor-positive Breast Cancer.
    Cancer Res Commun Volume: 2 Page(s): 1569 - 1578
    12/01/2022 Authors: Jones RB; Farhi J; Adams M; Parwani KK; Cooper GW; Zecevic M; Lee RS; Hong AL; Spangle JM
  • LOSS OF HISTONE H3 THREONINE 45 PHOSPHORYLATION DECREASES H3K36ME3 TO ABROGATE THE RADIATION-INDUCED DNA DAMAGE IN GLIOBLASTOMA MULTIFORME
    Volume: 24 Page(s): 91 - 91
    11/01/2022 Authors: Parwani K; Spangle J; McSwain L; Javadi RHS; Kenney A; Yu D
  • A Saccharomyces cerevisiae model and screen to define the functional consequences of oncogenic histone missense mutations.
    G3 (Bethesda) Volume: 12
    07/06/2022 Authors: Lemon LD; Kannan S; Mo KW; Adams M; Choi HG; Gulka AOD; Withers ES; Nurelegne HT; Gomez V; Ambrocio RE
  • Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine.
    Angew Chem Int Ed Engl Volume: 61 Page(s): e202112107
    01/26/2022 Authors: Tang K-C; Cao J; Boatner LM; Li L; Farhi J; Houk KN; Spangle J; Backus KM; Raj M
  • Medulloblastoma and the DNA Damage Response.
    Front Oncol Volume: 12 Page(s): 903830
    01/01/2022 Authors: McSwain LF; Parwani KK; Shahab SW; Hambardzumyan D; MacDonald TJ; Spangle JM; Kenney AM
  • Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs.
    Front Cell Dev Biol Volume: 10 Page(s): 909557
    01/01/2022 Authors: Lee M; Geitgey DK; Hamilton JAG; Boss JM; Scharer CD; Spangle JM; Haynes KA; Henry CJ
  • Practical advice for mentoring and supporting faculty colleagues in STEM fields: Views from mentor and mentee perspectives.
    J Biol Chem Volume: 297 Page(s): 101062
    09/01/2021 Authors: Spangle JM; Ghalei H; Corbett AH
  • PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K- inhibition.
    Proc Natl Acad Sci U S A Volume: 117 Page(s): 24427 - 24433
    09/29/2020 Authors: Spangle JM; Von T; Pavlick DC; Khotimsky A; Zhao JJ; Roberts TM
  • Epigenetic regulation of RTK signaling.
    J Mol Med (Berl) Volume: 95 Page(s): 791 - 798
    08/01/2017 Authors: Spangle JM; Roberts TM
  • The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.
    Biochim Biophys Acta Rev Cancer Volume: 1868 Page(s): 123 - 131
    08/01/2017 Authors: Spangle JM; Roberts TM; Zhao JJ
  • PI3K-p110 mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85.
    Proc Natl Acad Sci U S A Volume: 114 Page(s): 7095 - 7100
    07/03/2017 Authors: Thorpe LM; Spangle JM; Ohlson CE; Cheng H; Roberts TM; Cantley LC; Zhao JJ
  • PI3K-p110 mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers.
    Oncogene Volume: 35 Page(s): 3607 - 3612
    07/07/2016 Authors: Wang Q; Liu P; Spangle JM; Von T; Roberts TM; Lin NU; Krop IE; Winer EP; Zhao JJ
  • PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.
    Cell Rep Volume: 15 Page(s): 2692 - 2704
    06/21/2016 Authors: Spangle JM; Dreijerink KM; Groner AC; Cheng H; Ohlson CE; Reyes J; Lin CY; Bradner J; Zhao JJ; Roberts TM
  • The human papillomavirus type 8 E6 protein interferes with NOTCH activation during keratinocyte differentiation.
    J Virol Volume: 87 Page(s): 4762 - 4767
    04/01/2013 Authors: Meyers JM; Spangle JM; Munger K
  • The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species.
    PLoS Pathog Volume: 9 Page(s): e1003237
    03/01/2013 Authors: Spangle JM; Munger K
  • Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.
    Nature Volume: 487 Page(s): 491 - 495
    07/26/2012 Authors: Rozenblatt-Rosen O; Deo RC; Padi M; Adelmant G; Calderwood MA; Rolland T; Grace M; Dricot A; Askenazi M; Tavares M
  • Activation of cap-dependent translation by mucosal human papillomavirus E6 proteins is dependent on the integrity of the LXXLL binding motif.
    J Virol Volume: 86 Page(s): 7466 - 7472
    07/01/2012 Authors: Spangle JM; Ghosh-Choudhury N; Munger K
  • The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis.
    J Virol Volume: 84 Page(s): 9398 - 9407
    09/01/2010 Authors: Spangle JM; Mnger K
  • Expression of a viral oncoprotein in normal human epithelial cells triggers an autophagy-related process: is autophagy an "Achilles' heel" of human cancers?
    Autophagy Volume: 5 Page(s): 578 - 579
    05/01/2009 Authors: Zhou X; Spangle JM; Mnger K
  • Climate and life-history evolution in evening primroses (Oenothera, Onagraceae): a phylogenetic comparative analysis.
    Evolution Volume: 59 Page(s): 1914 - 1927
    09/01/2005 Authors: Evans MEK; Hearn DJ; Hahn WJ; Spangle JM; Venable DL
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