Jeong Hong
Research
Publications
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Evaluating elexacaftor/tezacaftor/ivacaftor (ETI; Trikafta) for treatment of patients with non-cystic fibrosis bronchiectasis (NCFBE): A clinical study protocol.
PLoS One Volume: 20 Page(s): e0316721
01/01/2025 Authors: Swenson CE; Hunt WR; Manfredi C; Beltran DJ; Hong JS; Davis BR; Suzuki S; Barill C; Rab A; Chico C -
Evaluation of elexacaftor-tezacaftor-ivacaftor treatment in individuals with cystic fibrosis and CFTRN1303K in the USA: a prospective, multicentre, open-label, single-arm trial.
Lancet Respir Med Volume: 12 Page(s): 947 - 957
12/01/2024 Authors: Solomon GM; Linnemann RW; Rich R; Streby A; Buehler B; Hunter E; Vijaykumar K; Hunt WR; Brewington JJ; Rab A -
Translation velocity determines the efficacy of engineered suppressor tRNAs on pathogenic nonsense mutations.
Nat Commun Volume: 15 Page(s): 2957
04/05/2024 Authors: Bharti N; Santos L; Davyt M; Behrmann S; Eichholtz M; Jimenez-Sanchez A; Hong JS; Rab A; Sorscher EJ; Albers S -
Mutation accumulation in H. sapiens F508del CFTR countermands dN/dS type genomic analysis.
PLoS One Volume: 19 Page(s): e0305832
01/01/2024 Authors: Hong JS; Tindall JM; Tindall SR; Sorscher EJ -
In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells.
iScience Volume: 26 Page(s): 108180
11/17/2023 Authors: Kleinfelder K; Lotti V; Eramo A; Amato F; Lo Cicero S; Castelli G; Spadaro F; Farinazzo A; Dell'Orco D; Preato S -
Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.
FASEB J Volume: 37 Page(s): e23220
11/01/2023 Authors: Tedbury PR; Manfredi C; Degenhardt F; Conway J; Horwath MC; McCracken C; Sorscher AJ; Moreau S; Wright C; Edwards C -
A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis.
ACS Med Chem Lett Volume: 14 Page(s): 1338 - 1343
10/12/2023 Authors: Rab A; Yang X; Tracy WF; Hong JS; Joshi D; Manfredi C; Ponnaluri SS; Kolykhalov AA; Qui M; Fu H -
Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics.
J Biol Chem Volume: 299 Page(s): 105242
10/01/2023 Authors: Kim M; McDonald EF; Sabusap CMP; Timalsina B; Joshi D; Hong JS; Rab A; Sorscher EJ; Plate L -
Engineered tRNAs suppress nonsense mutations in cells and in vivo.
Nature Volume: 618 Page(s): 842 - 848
06/01/2023 Authors: Albers S; Allen EC; Bharti N; Davyt M; Joshi D; Perez-Garcia CG; Santos L; Mukthavaram R; Delgado-Toscano MA; Molina B -
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo.
J Control Release Volume: 357 Page(s): 394 - 403
05/01/2023 Authors: Huayamares SG; Lokugamage MP; Rab R; Da Silva Sanchez AJ; Kim H; Radmand A; Loughrey D; Lian L; Hou Y; Achyut BR