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Profile

Joseph Le Doux

  • Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory
    Adjunct Professor
  • jledoux@emory.edu
Head shot of Joseph Le Doux

Overview

Joe Le Doux (he/him/his) is a Professor, Deans Education Innovation Professor, in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, and the Executive Leader for Education Transformation and Innovation at Emory University's School of Medicine. Dr. Le Douxs current projects are focused on fostering students intrapersonal competencies, including their self-concept clarity and entrepreneurial mindset, through story-driven learning, promoting inclusion in engineering education, and creating constructivist interactive learning environments that promote deep and transferable learning. He is a recipient of the 2019 Bernard M. Gordon Prize for Innovation in Engineering and Technology Education. He has also received several awards for his excellence in teaching including Georgia Techs 2005 Educational Partnership Award, 2014 Women in Engineering Teaching Excellence Award, and 2017 Curriculum Innovation Award. Dr. Le Douxs Bachelor's and Master's degrees are in Chemical Engineering from Cornell University and he holds a Ph.D. in Chemical and Biochemical Engineering from Rutgers University.

Research

Publications

  • Near-Real-Time Learner Analysis and Faculty Support During a Transition to Online Education.
    Biomed Eng Educ Volume: 1 Page(s): 345 - 351
    01/01/2021 Authors: Fernandez T; Le Doux J; Behravesh E
  • THE PROBLEM-SOLVING STUDIO: AN APPROACH FOR STRUCTURING FACE-TO-FACE LEARNING ACTIVITIES IN THE FLIPPED CLASSROOM
    Page(s): 289 - 313
    01/01/2019 Authors: Le Doux JM
  • Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency.
    Mol Ther Volume: 25 Page(s): 2372 - 2382
    10/04/2017 Authors: Tran R; Myers DR; Denning G; Shields JE; Lytle AM; Alrowais H; Qiu Y; Sakurai Y; Li WC; Brand O
  • High-throughput screening identifies compounds that enhance lentiviral transduction.
    Volume: 21 Page(s): 1008 - 1020
    12/01/2014 Authors: Johnston JM; Denning G; Moot R; Whitehead D; Shields J; Le Doux JM; Doering CB; Spencer HT
  • Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity.
    J Biol Chem Volume: 285 Page(s): 21249 - 21257
    07/09/2010 Authors: Wang XH; Zhang L; Mitch WE; LeDoux JM; Hu J; Du J
  • Rapid modification of retroviruses using lipid conjugates.
    Nanotechnology Volume: 20 Page(s): 065103
    02/11/2009 Authors: Mukherjee NG; Lyon LA; Le Doux JM
  • Quantitative analysis of retroviral and lentiviral gene transfer to murine embryonic stem cells.
    J Biotechnol Volume: 138 Page(s): 42 - 51
    11/06/2008 Authors: Chilton JM; Le Doux JM
  • Complexation of retroviruses with polymers significantly increases the number of genes transferred to murine embryonic stem cells, but does not raise transgene expression levels.
    Biotechnol Appl Biochem Volume: 51 Page(s): 141 - 151
    11/01/2008 Authors: Chilton JM; Le Doux JM
  • Engineering graded tissue interfaces.
    Proc Natl Acad Sci U S A Volume: 105 Page(s): 12170 - 12175
    08/26/2008 Authors: Phillips JE; Burns KL; Le Doux JM; Guldberg RE; Garca AJ
  • Amphotropic retrovirus transduction is inhibited by high doses of particle-associated envelope proteins.
    Biotechnol Bioeng Volume: 99 Page(s): 1205 - 1215
    04/01/2008 Authors: Landzuri N; Le Doux JM
  • Lentiviruses inefficiently incorporate human parainfluenza type 3 envelope proteins.
    Biotechnol Bioeng Volume: 99 Page(s): 1016 - 1027
    03/01/2008 Authors: Jung C; Le Doux JM
  • Gene therapy protocols volume 2: design and characterization of gene transfer vectors. Preface.
    Methods Mol Biol Volume: 434 Page(s): v
    01/01/2008 Authors: Le Doux JM
  • Biomaterial-mediated retroviral gene transfer using self-assembled monolayers.
    Biomaterials Volume: 28 Page(s): 5121 - 5127
    12/01/2007 Authors: Gersbach CA; Coyer SR; Le Doux JM; Garca AJ
  • Retrovirus-polymer complexes: study of the factors affecting the dose response of transduction.
    Biotechnol Prog Volume: 23 Page(s): 480 - 487
    01/01/2007 Authors: Landazuri N; Krishna D; Gupta M; Le Doux JM
  • Rapid concentration and purification of retrovirus by flocculation with Polybrene.
    J Biotechnol Volume: 125 Page(s): 529 - 539
    10/01/2006 Authors: Landzuri N; Gupta M; Le Doux JM
  • Murine leukemia virus particles activate Rac1 in HeLa cells.
    Biochem Biophys Res Commun Volume: 345 Page(s): 1184 - 1193
    07/07/2006 Authors: Krishna D; Le Doux JM
  • Inducible regulation of Runx2-stimulated osteogenesis.
    Gene Ther Volume: 13 Page(s): 873 - 882
    06/01/2006 Authors: Gersbach CA; Le Doux JM; Guldberg RE; Garca AJ
  • Inducible Regulation of Runx2-Stimulated Osteogenesis
    Volume: 13 Page(s): S222 - S223
    05/01/2006 Authors: Gersbach CA; Le Doux JM; Guldberg RE; Garcia AJ
  • Biomaterial-Mediated Retroviral Gene Delivery
    Volume: 13 Page(s): S315 - S316
    05/01/2006 Authors: Gersbach CA; Coyer SR; Le Doux JM; Garcia AJ
  • Complexation with chondroitin sulfate C and Polybrene rapidly purifies retrovirus from inhibitors of transduction and substantially enhances gene transfer.
    Biotechnol Bioeng Volume: 93 Page(s): 146 - 158
    01/05/2006 Authors: Landzuri N; Le Doux JM
  • Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus.
    J Virol Volume: 79 Page(s): 11742 - 11751
    09/01/2005 Authors: Murray JL; Mavrakis M; McDonald NJ; Yilla M; Sheng J; Bellini WJ; Zhao L; Le Doux JM; Shaw MW; Luo C-C
  • Highly efficient transduction of repopulating bone marrow cells using rapidly concentrated polymer-complexed retrovirus.
    Biochem Biophys Res Commun Volume: 330 Page(s): 768 - 775
    05/13/2005 Authors: McMillin DW; Landzuri N; Gangadharan B; Hewes B; Archer DR; Spencer HT; Le Doux JM
  • Targeted receptor trafficking affects the efficiency of retrovirus transduction.
    Biotechnol Prog Volume: 21 Page(s): 263 - 273
    01/01/2005 Authors: Krishna D; Raykin J; Le Doux JM
  • Complexation of retroviruses with charged polymers enhances gene transfer by increasing the rate that viruses are delivered to cells.
    J Gene Med Volume: 6 Page(s): 1304 - 1319
    12/01/2004 Authors: Landzuri N; Le Doux JM
  • Genetic modification of embryonic stems cells to ectopically express proendocrine factors
    Volume: 15 Page(s): 219A - 219A
    11/01/2004 Authors: Chilton JM; Le Doux JM; Archer DR
  • Lentiviral vectors pseudotyped with envelope glycoproteins derived from human parainfluenza virus type 3
    Volume: 9 Page(s): S278 - S278
    05/01/2004 Authors: Jung C; Grzybowski BN; Tong SX; Cheng LT; Compans RW; Le Doux JM
  • Receptor trafficking affects the efficiency of retrovirus transduction
    Volume: 9 Page(s): S277 - S278
    05/01/2004 Authors: Krishna D; Le Doux JM
  • Transduction of hematopoietic stem cells using polymer-concentrated ecotropic retrovirus coupled with in vivo selection of gene-modified cells
    Volume: 9 Page(s): S153 - S154
    05/01/2004 Authors: McMillin DW; Landazuri N; Gangadharan B; Archer D; Le Doux J; Spencer HT
  • Enhancement of retroviral-mediated gene transfer by purification of virus stocks from inhibitors of transduction
    Volume: 9 Page(s): S32 - S32
    05/01/2004 Authors: Landazuri N; Le Doux JM
  • Lentiviral vectors pseudotyped with envelope glycoproteins derived from human parainfluenza virus type 3.
    Biotechnol Prog Volume: 20 Page(s): 1810 - 1816
    01/01/2004 Authors: Jung C; Grzybowski BN; Tong S; Cheng L; Compans RW; Le Doux JM
  • High efficiency transduction of murine hematopoietic stem cells using transiently produced and concentrated ecotropic retroviral supernatant.
    Volume: 102 Page(s): 500B - 500B
    11/16/2003 Authors: McMillin D; Landazuri N; Archer D; Le Doux J; Spencer T
  • The development of an experimental system to investigate the role of host cell factors in retrovirus transduction
    Volume: 7 Page(s): S181 - S181
    05/01/2003 Authors: Krishna D; Coburn L; Sheng JS; Rubin DH; Hodge TW; Le Doux JM
  • Enhancement of gene transfer using polymer-complexed recombinant retroviruses
    Volume: 7 Page(s): S336 - S336
    05/01/2003 Authors: Landazuri N; LeDoux JM
  • Complexation of retrovirus with cationic and anionic polymers increases the efficiency of gene transfer.
    Hum Gene Ther Volume: 12 Page(s): 1611 - 1621
    09/01/2001 Authors: Le Doux JM; Landazuri N; Yarmush ML; Morgan JR
  • Toward a more accurate quantitation of the activity of recombinant retroviruses: alternatives to titer and multiplicity of infection.
    J Virol Volume: 74 Page(s): 3431 - 3439
    04/01/2000 Authors: Andreadis S; Lavery T; Davis HE; Le Doux JM; Yarmush ML; Morgan JR
  • Toward a more accurate quantitation of the activity of recombinant retroviruses: alternatives to titer and multiplicity of infection.
    J Virol Volume: 74 Page(s): 1258 - 1266
    02/01/2000 Authors: Andreadis S; Lavery T; Davis HE; Le Doux JM; Yarmush ML; Morgan JR
  • Kinetics of retrovirus production and decay.
    Biotechnol Bioeng Volume: 63 Page(s): 654 - 662
    06/20/1999 Authors: Le Doux JM; Davis HE; Morgan JR; Yarmush ML
  • Large-scale processing of recombinant retroviruses for gene therapy.
    Biotechnol Prog Volume: 15 Page(s): 1 - 11
    01/01/1999 Authors: Andreadis ST; Roth CM; Le Doux JM; Morgan JR; Yarmush ML
  • Differential inhibition of retrovirus transduction by proteoglycans and free glycosaminoglycans.
    Biotechnol Prog Volume: 15 Page(s): 397 - 406
    01/01/1999 Authors: Le Doux JM; Morgan JR; Yarmush ML
  • Removal of proteoglycans increases efficiency of retroviral gene transfer.
    Biotechnol Bioeng Volume: 58 Page(s): 23 - 34
    04/05/1998 Authors: Le Doux JM; Morgan JR; Yarmush ML
  • Targeted antisense modulation of inflammatory cytokine receptors.
    Biotechnol Bioeng Volume: 55 Page(s): 72 - 81
    07/05/1997 Authors: Roth CM; Reiken SR; Le Doux JM; Rajur SB; Lu XM; Morgan JR; Yarmush ML
  • Proteoglycans secreted by packaging cell lines inhibit retrovirus infection.
    J Virol Volume: 70 Page(s): 6468 - 6473
    09/01/1996 Authors: Le Doux JM; Morgan JR; Snow RG; Yarmush ML
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