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Profile

Julia LeCher

  • Department of Pediatrics
    Instructor
  • (404) 727-0729
  • julia.christine.lecher@emory.edu
Head shot of Julia LeCher

Research

Publications

  • Mechanism of Inhibition of the Active Triphosphate Form of 2'--Fluoro,2'--bromouridine against Yellow Fever Virus RNA-Dependent RNA Polymerase.
    ACS Infect Dis Volume: 11 Page(s): 1528 - 1538
    06/13/2025 Authors: Gordon CJ; Walker SM; LeCher JC; Amblard F; Schinazi RF; Gtte M
  • Combating yellow fever virus with 7-deaza-7-fluoro-2'-C-methyladenosine.
    Antimicrob Agents Chemother Volume: 69 Page(s): e0188924
    05/07/2025 Authors: LeCher JC; Costa VV; Rust LN; Bassit LC; Patel D; Rezaei S; Moua J; Santos FRDS; Goncalves MR; Queroz-Junior CM
  • Development of robust antiviral assays using relevant apical-out human airway organoids.
    bioRxiv
    07/12/2024 Authors: Lee J-H; LeCher JC; Parigoris E; Shinagawa N; Sentosa J; Manfredi C; Goh SL; De R; Tao S; Zandi K
  • Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 Infections.
    Viruses Volume: 16
    04/22/2024 Authors: Hurwitz SJ; De R; LeCher JC; Downs-Bowen JA; Goh SL; Zandi K; McBrayer T; Amblard F; Patel D; Kohler JJ
  • Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
    Eur J Med Chem Volume: 268 Page(s): 116263
    03/15/2024 Authors: Amblard F; LeCher JC; De R; Zhou S; Liu P; Goh SL; Tao S; Patel D; Downs-Bowen J; Zandi K
  • Utilization of a cell-penetrating peptide-adaptor for delivery of human papillomavirus protein E2 into cervical cancer cells to arrest cell growth and promote cell death.
    Cancer Rep (Hoboken) Volume: 6 Page(s): e1810
    05/01/2023 Authors: LeCher JC; Didier HL; Dickson RL; Slaughter LR; Bejarano JC; Ho S; Nowak SJ; Chrestensen CA; McMurry JL
  • Synthesis of 4'-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents.
    Viruses Volume: 15
    02/16/2023 Authors: Biteau NG; Amichai SA; Azadi N; De R; Downs-Bowen J; Lecher JC; MacBrayer T; Schinazi RF; Amblard F
  • Discovery of a 2'-Fluoro,2'-Bromouridine Phosphoramidate Prodrug Exhibiting Anti-Yellow Fever Virus Activity in Culture and in Mice.
    Microorganisms Volume: 10
    10/22/2022 Authors: LeCher JC; Zandi K; Costa VV; Amblard F; Tao S; Patel D; Lee S; da Silva Santos FR; Goncalves MR; Queroz-Junior CM
  • Synthesis of Novel N4-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents.
    Pharmaceuticals (Basel) Volume: 15
    09/14/2022 Authors: Amblard F; LeCher JC; De R; Goh SL; Li C; Kasthuri M; Biteau N; Zhou L; Tber Z; Downs-Bowen J
  • Baricitinib attenuates the proinflammatory phase of COVID-19 driven by lung-infiltrating monocytes.
    Cell Rep Volume: 39 Page(s): 110945
    06/14/2022 Authors: Dobosh B; Zandi K; Giraldo DM; Goh SL; Musall K; Aldeco M; LeCher J; Giacalone VD; Yang J; Eddins DJ
  • Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside.
    Curr Res Pharmacol Drug Discov Volume: 2 Page(s): 100045
    01/01/2021 Authors: Tao S; Zandi K; Bassit L; Ong YT; Verma K; Liu P; Downs-Bowen JA; McBrayer T; LeCher JC; Kohler JJ
  • Genistein Has Antiviral Activity against Herpes B Virus and Acts Synergistically with Antiviral Treatments to Reduce Effective Dose.
    Viruses Volume: 11
    05/31/2019 Authors: LeCher JC; Diep N; Krug PW; Hilliard JK
  • Breaking in and busting out: cell-penetrating peptides and the endosomal escape problem.
    Biomol Concepts Volume: 8 Page(s): 131 - 141
    09/26/2017 Authors: LeCher JC; Nowak SJ; McMurry JL
  • B Virus (Macacine Herpesvirus 1) Divergence: Variations in Glycoprotein D from Clinical and Laboratory Isolates Diversify Virus Entry Strategies.
    J Virol Volume: 90 Page(s): 9420 - 9432
    10/15/2016 Authors: Patrusheva I; Perelygina L; Torshin I; LeCher J; Hilliard J
  • 2015 Colorado Alphaherpesvirus Latency Society Symposium.
    J Neurovirol Volume: 21 Page(s): 706 - 716
    12/01/2015 Authors: Cohrs RJ; Gilden D
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