James Lah MD/PhD
Academic Appointment
- Alice and Roy Richards Chair, Neurology, Emory University
- Vice Chair, Neurology, Emory University
- Associate Professor, Neurology, Emory University
- Training Faculty, Graduate Division of Biological and Biomedical Sciences, Emory University
- Training Faculty, Neuroscience Program, Emory University
Education
Degrees
- BS from Duke University
- MD-PhD from Ohio State University
Research
Focus
- My research is driven by the goal of understanding basic pathogenic mechanisms in neurodegenerative disorders. Specific topics of interest include: regulation of amyloid precursor protein (APP) processing through control of intracellular trafficking, analysis of the role of the apolipoprotein E (ApoE) receptor LR11 in amyloidogenesis, modulation of APP processing by muscarinic receptor activity, and characterization of new genes involved in Alzheimers disease, Parkinsons disease, Frontotemporal Dementia, and other neurodegenerative disorders.
Publications
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County Health Departments Facilitate Telehealth Dementia Evaluation: The Georgia Memory Net Collaboration.
Telemed J E Health
04/21/2025 Authors: Loring DW; Lah JJ; Head EN; Hale CL; McIntosh RL -
The association between pulse wave velocity and cerebrospinal fluid biomarkers for Alzheimer's disease.
J Alzheimers Dis Page(s): 13872877251331235
04/21/2025 Authors: Kim H; Kulshreshtha A; Alonso A; Goldstein FC; Johnson EC; Gold ME; Quyyumi AA; Lah JJ -
Proteomic Subtyping of Alzheimer's Disease CSF links Blood-Brain Barrier Dysfunction to Reduced levels of Tau and Synaptic Biomarkers.
03/15/2025 Authors: Bangs MC; Gadhavi J; Carter EK; Ping L; Duong DM; Dammer EB; Wu F; Shantaraman A; Fox EJ; Johnson ECB -
Probing locus coeruleus functional network in healthy aging and its association with Alzheimer's disease biomarkers using pupillometry.
Alzheimers Res Ther Volume: 17 Page(s): 53
02/27/2025 Authors: Wu J; Toporek A; Lin Q; Goldstein FC; Loring DW; Kelberman MA; Weinshenker D; Levey AI; Lah JJ; Qiu D -
Accelerated model-based T1, T2* and proton density mapping using a Bayesian approach with automatic hyperparameter estimation.
Magn Reson Med Volume: 93 Page(s): 563 - 583
02/01/2025 Authors: Huang S; Lah JJ; Allen JW; Qiu D -
Survival of Patients at a Neurology Clinic: No Improvement Over 12 Years.
Alzheimer Dis Assoc Disord
01/30/2025 Authors: Steenland K; Tan Y; Mullins SM; Kidd TE; Gong Q; Lah JJ -
ABBA Letter Alternation: A telehealth inspired measure of executive functioning/inhibitory control.
Clin Neuropsychol Page(s): 1 - 12
01/09/2025 Authors: Loring DW; Hewitt KC; Drane DL; Zhao L; Xu H; Lah JJ; Goldstein FC -
Stratifying risk of Alzheimer's disease in healthy middle-aged individuals with machine learning.
Brain Commun Volume: 7 Page(s): fcaf121
01/01/2025 Authors: Tandon R; Zhao L; Watson CM; Sarkar N; Elmor M; Heilman C; Sanders K; Hales CM; Yang H; Loring DW -
CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment.
Alzheimers Dement (N Y) Volume: 11 Page(s): e70051
01/01/2025 Authors: Hajs M; Pandey K; Singer AC; Duong D; Bitarafan S; Shpokayte M; Malchano Z; Kern R; Lah JJ; Levey AI -
Technology literacy and access to digital resources for remote assessment among adults enrolled in Alzheimer's disease research.
J Alzheimers Dis Volume: 102 Page(s): 1286 - 1296
12/01/2024 Authors: Okafor M; Yang Z; Vickers KL; Sanders K; Simama N; Hewitt KC; Lah J; Levey AI; Goldstein FC; Hajjar I -
Receptive vocabulary is superior to education level to account for Black and White neuropsychological performance discrepancies.
J Int Neuropsychol Soc Volume: 30 Page(s): 998 - 1002
12/01/2024 Authors: Goldstein FC; Hanfelt JJ; James TA; Lah JJ; Loring DW -
Simplifying Complex Figure scoring: Data from the Emory Healthy Brain Study and initial clinical validation.
J Int Neuropsychol Soc Volume: 30 Page(s): 992 - 997
12/01/2024 Authors: Loring DW; Simama N; Sanders K; Saurman JR; Zhao L; Lah JJ; Goldstein FC -
Large-scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity.
Alzheimers Dement Volume: 20 Page(s): 8878 - 8897
12/01/2024 Authors: Seifar F; Fox EJ; Shantaraman A; Liu Y; Dammer EB; Modeste E; Duong DM; Yin L; Trautwig AN; Guo Q -
Correction: Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer's disease.
Mol Neurodegener Volume: 19 Page(s): 71
10/11/2024 Authors: Shantaraman A; Dammer EB; Ugochukwu O; Duong DM; Yin L; Carter EK; Gearing M; Chen-Plotkin A; Lee EB; Trojanowski JQ -
Heparin-enriched plasma proteome is significantly altered in Alzheimer's disease.
Mol Neurodegener Volume: 19 Page(s): 67
10/08/2024 Authors: Guo Q; Ping L; Dammer EB; Duong DM; Yin L; Xu K; Shantaraman A; Fox EJ; Golde TE; Johnson ECB -
Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations.
Alzheimers Dement Volume: 20 Page(s): 7174 - 7192
10/01/2024 Authors: Reddy JS; Heath L; Linden AV; Allen M; Lopes KDP; Seifar F; Wang E; Ma Y; Poehlman WL; Quicksall ZS -
An interim exploratory proteomics biomarker analysis of a phase 2 clinical trial to assess the impact of CT1812 in Alzheimer's disease.
Neurobiol Dis Volume: 199 Page(s): 106575
09/01/2024 Authors: Lizama BN; North HA; Pandey K; Williams C; Duong D; Cho E; Di Caro V; Ping L; Blennow K; Zetterberg H -
Lower Prevalence of Asymptomatic Alzheimer's Disease Among Healthy African Americans.
Ann Neurol Volume: 96 Page(s): 463 - 475
09/01/2024 Authors: Lah JJ; Tian G; Risk BB; Hanfelt JJ; Wang L; Zhao L; Hales CM; Johnson ECB; Elmor MB; Malakauskas SJ -
Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer's disease.
Mol Neurodegener Volume: 19 Page(s): 60
08/06/2024 Authors: Shantaraman A; Dammer EB; Ugochukwu O; Duong DM; Yin L; Carter EK; Gearing M; Chen-Plotkin A; Lee EB; Trojanowski JQ -
A deep spatio-temporal attention model of dynamic functional network connectivity shows sensitivity to Alzheimer's in asymptomatic individuals.
Volume: 2024 Page(s): 1 - 4
07/01/2024 Authors: Wei Y; Abrol A; Lah J; Qiu D; Calhoun VD -
Proteomic analysis of Alzheimer's disease cerebrospinal fluid reveals alterations associated with APOE 4 and atomoxetine treatment.
Sci Transl Med Volume: 16 Page(s): eadn3504
06/26/2024 Authors: Dammer EB; Shantaraman A; Ping L; Duong DM; Gerasimov ES; Ravindran SP; Gudmundsdottir V; Frick EA; Gomez GT; Walker KA -
s-SuStaIn: Scaling subtype and stage inference via simultaneous clustering of subjects and biomarkers.
Volume: 248 Page(s): 461 - 476
06/01/2024 Authors: Tandon R; Lah JJ; Mitchell CS -
Proteomic changes in the human cerebrovasculature in Alzheimer's disease and related tauopathies linked to peripheral biomarkers in plasma and cerebrospinal fluid.
Alzheimers Dement Volume: 20 Page(s): 4043 - 4065
06/01/2024 Authors: Wojtas AM; Dammer EB; Guo Q; Ping L; Shantaraman A; Duong DM; Yin L; Fox EJ; Seifar F; Lee EB -
Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial.
JAMA Neurol Volume: 81 Page(s): 582 - 593
06/01/2024 Authors: Wagemann O; Liu H; Wang G; Shi X; Bittner T; Scelsi MA; Farlow MR; Clifford DB; Supnet-Bell C; Santacruz AM -
Contribution of Peripheral Microvascular Dysfunction to Mild Cognitive Impairment.
Am J Cardiol Volume: 218 Page(s): 4 - 6
05/01/2024 Authors: Gold ME; Rogers SC; Kulshreshtha A; Chen Y; Ko Y-A; Cheng ML; Gold DA; Vatsa N; Jain V; Desai S -
Joint effects of air pollution and neighborhood socioeconomic status on cognitive decline - Mediation by depression, high cholesterol levels, and high blood pressure.
Sci Total Environ Volume: 923 Page(s): 171535
05/01/2024 Authors: Mei Y; Christensen GM; Li Z; Waller LA; Ebelt S; Marcus M; Lah JJ; Wingo AP; Wingo TS; Hls A -
The association between neighborhood deprivation and DNA methylation in an autopsy cohort.
Aging (Albany NY) Volume: 16 Page(s): 6694 - 6716
04/24/2024 Authors: Pett L; Li Z; Abrishamcar S; Hodge K; Everson T; Christensen G; Gearing M; Kobor MS; Konwar C; MacIsaac JL -
APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's disease pathology.
Neuron Volume: 112 Page(s): 1110 - 1116.e5
04/03/2024 Authors: Chemparathy A; Le Guen Y; Chen S; Lee E-G; Leong L; Gorzynski JE; Jensen TD; Ferrasse A; Xu G; Xiang H -
Disentangling Visual Exploration Differences in Cognitive Impairment.
IEEE Trans Biomed Eng Volume: 71 Page(s): 1197 - 1208
04/01/2024 Authors: Jiang Z; Seyedi S; Vickers KL; Manzanares CM; Lah JJ; Levey AI; Clifford GD -
Association between Fine Particulate Matter Exposure and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease among a Cognitively Healthy Population-Based Cohort.
Environ Health Perspect Volume: 132 Page(s): 47001
04/01/2024 Authors: Casey E; Li Z; Liang D; Ebelt S; Levey AI; Lah JJ; Wingo TS; Hls A -
Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease.
Alzheimers Dement Volume: 20 Page(s): 2698 - 2706
04/01/2024 Authors: Wang G; Li Y; Xiong C; Benzinger TLS; Gordon BA; Hassenstab J; Aschenbrenner AJ; McDade E; Clifford DB; Libre-Guerra JJ -
Differential DNA methylation in the brain as potential mediator of the association between traffic-related PM2.5 and neuropathology markers of Alzheimer's disease.
Alzheimers Dement Volume: 20 Page(s): 2538 - 2551
04/01/2024 Authors: Li Z; Liang D; Ebelt S; Gearing M; Kobor MS; Konwar C; Maclsaac JL; Dever K; Wingo AP; Levey AI -
Association of PM2.5 Exposure and Alzheimer Disease Pathology in Brain Bank Donors-Effect Modification by APOE Genotype.
Neurology Volume: 102 Page(s): e209162
03/12/2024 Authors: Christensen GM; Li Z; Liang D; Ebelt S; Gearing M; Levey AI; Lah JJ; Wingo A; Wingo T; Hls A -
Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White Individuals.
Ann Neurol Volume: 95 Page(s): 495 - 506
03/01/2024 Authors: Bonomi S; Lu R; Schindler SE; Bui Q; Lah JJ; Wolk D; Gleason CE; Sperling R; Roberson ED; Levey AI -
Direct to Consumer Biomarker Testing for Alzheimer Disease-Are We Ready for the Insurance Consequences?
JAMA Neurol Volume: 81 Page(s): 107 - 108
02/01/2024 Authors: Arias JJ; Manchester M; Lah J -
Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer's Disease.
01/24/2024 Authors: Shantaraman A; Dammer EB; Ugochukwu O; Duong DM; Yin L; Carter EK; Gearing M; Chen-Plotkin A; Lee EB; Trojanowski JQ -
Proteomic Changes in the Human Cerebrovasculature in Alzheimer's Disease and Related Tauopathies Linked to Peripheral Biomarkers in Plasma and Cerebrospinal Fluid.
01/11/2024 Authors: Wojtas AM; Dammer EB; Guo Q; Ping L; Shantaraman A; Duong DM; Yin L; Fox EJ; Seifar F; Lee EB -
Alzheimer's disease cerebrospinal fluid biomarkers and kidney function in normal and cognitively impaired older adults.
Alzheimers Dement (Amst) Volume: 16 Page(s): e12581
01/01/2024 Authors: Hajjar I; Neal R; Yang Z; Lah JJ -
Mixture of regressions with multivariate responses for discovering subtypes in Alzheimer's biomarkers with detection limits.
Data Sci Sci Volume: 3
01/01/2024 Authors: Tian G; Hanfelt J; Lah J; Risk BB -
Comparison of Quantitative Hippocampal Volumes and Structured Scoring Scales in Predicting Alzheimer Disease Diagnosis.
AJNR Am J Neuroradiol Volume: 44 Page(s): 1411 - 1417
12/11/2023 Authors: Essien M; Lah J; Weinberg BD; Allen JW; Hu R -
Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.
EBioMedicine Volume: 97 Page(s): 104820
11/01/2023 Authors: Jo T; Kim J; Bice P; Huynh K; Wang T; Arnold M; Meikle PJ; Giles C; Kaddurah-Daouk R; Saykin AJ -
Proteomic Network Analysis of Alzheimer's Disease Cerebrospinal Fluid Reveals Alterations Associated with APOE 4 Genotype and Atomoxetine Treatment.
medRxiv
10/30/2023 Authors: Dammer EB; Shantaraman A; Ping L; Duong DM; Gerasimov ES; Ravindran SP; Gudmundsdottir V; Frick EA; Gomez GT; Walker KA -
Unbiased classification of the elderly human brain proteome resolves distinct clinical and pathophysiological subtypes of cognitive impairment.
Neurobiol Dis Volume: 186 Page(s): 106286
10/01/2023 Authors: Higginbotham L; Carter EK; Dammer EB; Haque RU; Johnson ECB; Duong DM; Yin L; De Jager PL; Bennett DA; Felsky D -
Robust quantitative susceptibility mapping via approximate message passing with parameter estimation.
Magn Reson Med Volume: 90 Page(s): 1414 - 1430
10/01/2023 Authors: Huang S; Lah JJ; Allen JW; Qiu D -
A protein panel in cerebrospinal fluid for diagnostic and predictive assessment of Alzheimer's disease.
Sci Transl Med Volume: 15 Page(s): eadg4122
09/06/2023 Authors: Haque R; Watson CM; Liu J; Carter EK; Duong DM; Lah JJ; Wingo AP; Roberts BR; Johnson ECB; Saykin AJ -
Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism.
Sci Rep Volume: 13 Page(s): 13752
08/23/2023 Authors: Borkowski K; Seyfried NT; Arnold M; Lah JJ; Levey AI; Hales CM; Dammer EB; Blach C; Louie G; Kaddurah-Daouk R -
Author Correction: Predicting Alzheimer's disease progression using multi-modal deep learning approach.
Sci Rep Volume: 13 Page(s): 12466
08/01/2023 Authors: Lee G; Nho K; Kang B; Sohn K-A; Kim D; Alzheimers Disease Neuroimaging Initiative -
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease.
Nat Med Volume: 29 Page(s): 1979 - 1988
08/01/2023 Authors: Johnson ECB; Bian S; Haque RU; Carter EK; Watson CM; Gordon BA; Ping L; Duong DM; Epstein MP; McDade E -
Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment.
BMC Geriatr Volume: 23 Page(s): 462
07/31/2023 Authors: Tuena C; Maestri S; Serino S; Pedroli E; Stramba-Badiale M; Riva G; Alzheimers Disease Neuroimaging Initiative -
APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology.
medRxiv
07/24/2023 Authors: Chemparathy A; Guen YL; Chen S; Lee E-G; Leong L; Gorzynski J; Xu G; Belloy M; Kasireddy N; Tauber AP -
Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer's disease.
Mol Neurodegener Volume: 18 Page(s): 48
07/19/2023 Authors: Modeste ES; Ping L; Watson CM; Duong DM; Dammer EB; Johnson ECB; Roberts BR; Lah JJ; Levey AI; Seyfried NT -
Differential DNA Methylation in the Brain as Potential Mediator of the Association between Traffic-related PM2.5 and Neuropathology Markers of Alzheimer's Disease.
medRxiv
06/30/2023 Authors: Li Z; Liang D; Ebelt S; Gearing M; Kobor MS; Konwar C; Maclsaac JL; Dever K; Wingo A; Levey A -
Associations between neuropsychiatric symptoms of affective and vegetative domains and brain morphology in aging people with mild cognitive impairment and Alzheimer's disease.
Int J Geriatr Psychiatry Volume: 38 Page(s): e5952
06/01/2023 Authors: Cannizzaro A; Ronat L; El Haffaf LM; Hanganu A; ADNI -
Telehealth equivalence of the Montreal cognitive assessment (MoCA): Results from the Emory healthy brain study (EHBS).
J Am Geriatr Soc Volume: 71 Page(s): 1931 - 1936
06/01/2023 Authors: Loring DW; Lah JJ; Goldstein FC -
Magnetic resonance evidence of increased iron content in subcortical brain regions in asymptomatic Alzheimer's disease.
Hum Brain Mapp Volume: 44 Page(s): 3072 - 3083
06/01/2023 Authors: Lin Q; Shahid S; Hone-Blanchet A; Huang S; Wu J; Bisht A; Loring D; Goldstein F; Levey A; Crosson B -
Quantitative Mass Spectrometry Analysis of Cerebrospinal Fluid Protein Biomarkers in Alzheimer's Disease.
Sci Data Volume: 10 Page(s): 261
05/09/2023 Authors: Watson CM; Dammer EB; Ping L; Duong DM; Modeste E; Carter EK; Johnson ECB; Levey AI; Lah JJ; Roberts BR -
The Rey Auditory Verbal Learning Test: Cross-validation of Mayo Normative Studies (MNS) demographically corrected norms with confidence interval estimates.
J Int Neuropsychol Soc Volume: 29 Page(s): 397 - 405
05/01/2023 Authors: Loring DW; Saurman JL; John SE; Bowden SC; Lah JJ; Goldstein FC -
Fine particulate air pollution and neuropathology markers of Alzheimer's disease in donors with and without APOE 4 alleles - results from an autopsy cohort.
medRxiv
04/07/2023 Authors: Christensen GM; Li Z; Liang D; Ebelt S; Gearing M; Levey AI; Lah JJ; Wingo AP; Wingo TS; Huels A -
Alzheimer's disease genetic burden is associated with mid-life depression among persons with normal cognition.
Alzheimers Dement Volume: 19 Page(s): 868 - 874
03/01/2023 Authors: Wingo TS; Gerasimov ES; Canon SM; Lah JJ; Levey AI; Wingo AP -
Predictors of Cognitive Decline in Healthy Middle-Aged Individuals with Asymptomatic Alzheimer's Disease.
Res Sq
02/28/2023 Authors: Tandon R; Zhao L; Watson CM; Elmor M; Heilman C; Sanders K; Hales CM; Yang H; Loring DW; Goldstein FC -
Blood-based biomarkers in Alzheimer's disease: Future directions for implementation.
Alzheimers Dement (Amst) Volume: 15 Page(s): e12508
01/01/2023 Authors: Suridjan I; van der Flier WM; Monsch AU; Burnie N; Baldor R; Sabbagh M; Vilaseca J; Cai D; Carboni M; Lah JJ -
Machine Learning Selection of Most Predictive Brain Proteins Suggests Role of Sugar Metabolism in Alzheimer's Disease.
J Alzheimers Dis Volume: 92 Page(s): 411 - 424
01/01/2023 Authors: Tandon R; Levey AI; Lah JJ; Seyfried NT; Mitchell CS -
Multi-platform proteomic analysis of Alzheimer's disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome.
Alzheimers Res Ther Volume: 14 Page(s): 174
11/17/2022 Authors: Dammer EB; Ping L; Duong DM; Modeste ES; Seyfried NT; Lah JJ; Levey AI; Johnson ECB -
CSF proteome profiling across the Alzheimer's disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels.
Nat Aging Volume: 2 Page(s): 1040 - 1053
11/01/2022 Authors: Del Campo M; Peeters CFW; Johnson ECB; Vermunt L; Hok-A-Hin YS; van Nee M; Chen-Plotkin A; Irwin DJ; Hu WT; Lah JJ -
Examination of the reliability and feasibility of two smartphone applications to assess executive functioning in racially diverse older adults.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn Volume: 29 Page(s): 1068 - 1086
11/01/2022 Authors: John SE; Evans SA; Kim B; Ozgul P; Loring DW; Parker M; Lah JJ; Levey AI; Goldstein FC -
Multimodal Machine Learning to Identify Risk of Progression in Asymptomatic Alzheimer's Disease
Volume: 92 Page(s): S56 - S56
10/01/2022 Authors: Tandon R; Watson CM; Seyfried NT; Lah JJ; Mitchell CS -
Network Proteomic Analysis Identifies Diverse Pathophysiological Signatures in the Lewy Body Dementia Brain
Volume: 92 Page(s): S61 - S61
10/01/2022 Authors: Higginbotham L; Dammer EB; Shantaraman A; Duong DM; Yin L; Chen-Plotkin A; Lee EB; Lah JJ; Levey AI; Seyfried NT -
Race-Dependent Differences in Biomarkers Lead to Lower Rates of Alzheimer's Disease Classification in Symptomatic and Asymptomatic African Americans
Volume: 92 Page(s): S58 - S59
10/01/2022 Authors: Lah JJ; Parker MW; Tian G; Hales CM; Johnson ECB; Hanfelt JJ; Risk BB; Levey AI; Hajjar IM -
A probabilistic Bayesian approach to recover R2*$$ {R}_{2\ast } $$ map and phase images for quantitative susceptibility mapping.
Magn Reson Med Volume: 88 Page(s): 1624 - 1642
10/01/2022 Authors: Huang S; Lah JJ; Allen JW; Qiu D -
The trend of disruption in the functional brain network topology of Alzheimer's disease.
Sci Rep Volume: 12 Page(s): 14998
09/02/2022 Authors: Fathian A; Jamali Y; Raoufy MR; Alzheimers Disease Neuroimaging Initiative -
The complex relationship of air pollution and neighborhood socioeconomic status and their association with cognitive decline.
Environ Int Volume: 167 Page(s): 107416
09/01/2022 Authors: Christensen GM; Li Z; Pearce J; Marcus M; Lah JJ; Waller LA; Ebelt S; Hls A -
Neighborhood characteristics as confounders and effect modifiers for the association between air pollution exposure and subjective cognitive functioning.
Environ Res Volume: 212 Page(s): 113221
09/01/2022 Authors: Li Z; Christensen GM; Lah JJ; Marcus M; Russell AG; Ebelt S; Waller LA; Hls A -
Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment.
Geroscience Volume: 44 Page(s): 2319 - 2336
08/01/2022 Authors: Jiang J; Sheng C; Chen G; Liu C; Jin S; Li L; Jiang X; Han Y; Alzheimers Disease Neuroimaging Initiative -
Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.
Nat Commun Volume: 13 Page(s): 4006
07/11/2022 Authors: Yan T; Liang J; Gao J; Wang L; Fujioka H; Alzheimer Disease Neuroimaging Initiative; Zhu X; Wang X -
Genetic Evidence Supporting a Causal Role of Depression in Alzheimer's Disease.
Biol Psychiatry Volume: 92 Page(s): 25 - 33
07/01/2022 Authors: Harerimana NV; Liu Y; Gerasimov ES; Duong D; Beach TG; Reiman EM; Schneider JA; Boyle P; Lori A; Bennett DA -
A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment.
Brain Volume: 145 Page(s): 1924 - 1938
06/30/2022 Authors: Levey AI; Qiu D; Zhao L; Hu WT; Duong DM; Higginbotham L; Dammer EB; Seyfried NT; Wingo TS; Hales CM -
Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90.
Sci Rep Volume: 12 Page(s): 6117
04/12/2022 Authors: Heath L; Earls JC; Magis AT; Kornilov SA; Lovejoy JC; Funk CC; Rappaport N; Logsdon BA; Mangravite LM; Kunkle BW -
New insights into the genetic etiology of Alzheimer's disease and related dementias.
Nat Genet Volume: 54 Page(s): 412 - 436
04/01/2022 Authors: Bellenguez C; Kkali F; Jansen IE; Kleineidam L; Moreno-Grau S; Amin N; Naj AC; Campos-Martin R; Grenier-Boley B; Andrade V -
The Georgia Memory Net: Implementation of a statewide program to diagnose and treat Alzheimer's disease and related dementias.
J Am Geriatr Soc Volume: 70 Page(s): 1257 - 1267
04/01/2022 Authors: Bender AA; McIntosh RL; Sudduth S; Harris M; Tuckey K; Morgan JC; Jungerman JM; Cox A; Moore MA; Ingram B -
Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer's disease.
Nat Commun Volume: 13 Page(s): 1495
03/21/2022 Authors: Duong MT; Das SR; Lyu X; Xie L; Richardson H; Xie SX; Yushkevich PA; Alzheimers Disease Neuroimaging Initiative (ADNI); Wolk DA; Nasrallah IM -
Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Nat Neurosci Volume: 25 Page(s): 213 - 225
02/01/2022 Authors: Johnson ECB; Carter EK; Dammer EB; Duong DM; Gerasimov ES; Liu Y; Liu J; Betarbet R; Ping L; Yin L -
Brain microRNAs are associated with variation in cognitive trajectory in advanced age.
Transl Psychiatry Volume: 12 Page(s): 47
02/01/2022 Authors: Wingo AP; Wang M; Liu J; Breen MS; Yang H-S; Tang B; Schneider JA; Seyfried NT; Lah JJ; Levey AI -
Cerebral A deposition in an A-precursor protein-transgenic rhesus monkey.
Aging Brain Volume: 2
01/01/2022 Authors: Chan AWS; Cho IK; Li C-X; Zhang X; Patel S; Rusnak R; Raper J; Bachevalier J; Moran SP; Chi T -
Safety and biomarker effects of candesartan in non-hypertensive adults with prodromal Alzheimer's disease.
Brain Commun Volume: 4 Page(s): fcac270
01/01/2022 Authors: Hajjar I; Okafor M; Wan L; Yang Z; Nye JA; Bohsali A; Shaw LM; Levey AI; Lah JJ; Calhoun VD -
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Neurobiol Aging Volume: 109 Page(s): 22 - 30
01/01/2022 Authors: Hone-Blanchet A; Bohsali A; Krishnamurthy LC; Shahid S; Lin Q; Zhao L; Loring D; Goldstein F; John SE; Fleischer CC -
Multimodal magnetic resonance imaging reveals distinct sensitivity of hippocampal subfields in asymptomatic stage of Alzheimer's disease.
Front Aging Neurosci Volume: 14 Page(s): 901140
01/01/2022 Authors: Wu J; Shahid SS; Lin Q; Hone-Blanchet A; Smith JL; Risk BB; Bisht AS; Loring DW; Goldstein FC; Levey AI -
From paper to screen: regulatory and operational considerations for modernizing the informed consent process.
J Clin Transl Sci Volume: 6 Page(s): e71
01/01/2022 Authors: Cobb NL; Edwards DF; Chin EM; Lah JJ; Goldstein FC; Manzanares CM; Suver CM -
Frontal Metabolites and Alzheimer's Disease Biomarkers in Healthy Older Women and Women Diagnosed with Mild Cognitive Impairment.
J Alzheimers Dis Volume: 87 Page(s): 1131 - 1141
01/01/2022 Authors: Hone-Blanchet A; Bohsali A; Krishnamurthy LC; Shahid SS; Lin Q; Zhao L; Bisht AS; John SE; Loring D; Goldstein F -
Automated analysis of facial emotions in subjects with cognitive impairment.
PLoS One Volume: 17 Page(s): e0262527
01/01/2022 Authors: Jiang Z; Seyedi S; Haque RU; Pongos AL; Vickers KL; Manzanares CM; Lah JJ; Levey AI; Clifford GD -
A deep learning framework identifies dimensional representations of Alzheimer's Disease from brain structure.
Nat Commun Volume: 12 Page(s): 7065
12/03/2021 Authors: Yang Z; Nasrallah IM; Shou H; Wen J; Doshi J; Habes M; Erus G; Abdulkadir A; Resnick SM; Albert MS -
Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.
Nat Commun Volume: 12 Page(s): 7035
12/02/2021 Authors: Ma Y; Dammer EB; Felsky D; Duong DM; Klein H-U; White CC; Zhou M; Logsdon BA; McCabe C; Xu J -
Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Alzheimers Dement Volume: 17 Suppl 3 Page(s): e055041
12/01/2021 Authors: Johnson ECB; Carter EK; Dammer EB; Duong DM; Liu Y; Liu J; Betarbet R; Ping L; Yin L; Beach TG -
Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer's amyloid, tau and FDG PET status.
Transl Psychiatry Volume: 11 Page(s): 585
11/13/2021 Authors: Shen X-N; Huang Y-Y; Chen S-D; Guo Y; Tan L; Dong Q; Yu J-T; Alzheimers Disease Neuroimaging Initiative -
Effect of Methylphenidate on Apathy in Patients With Alzheimer Disease: The ADMET 2 Randomized Clinical Trial.
JAMA Neurol Volume: 78 Page(s): 1324 - 1332
11/01/2021 Authors: Mintzer J; Lanctt KL; Scherer RW; Rosenberg PB; Herrmann N; van Dyck CH; Padala PR; Brawman-Mintzer O; Porsteinsson AP; Lerner AJ -
Tau-Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease.
Ann Neurol Volume: 90 Page(s): 751 - 762
11/01/2021 Authors: Das SR; Lyu X; Duong MT; Xie L; McCollum L; de Flores R; DiCalogero M; Irwin DJ; Dickerson BC; Nasrallah IM -
Staging tau pathology with tau PET in Alzheimer's disease: a longitudinal study.
Transl Psychiatry Volume: 11 Page(s): 483
09/18/2021 Authors: Chen S-D; Lu J-Y; Li H-Q; Yang Y-X; Jiang J-H; Cui M; Zuo C-T; Tan L; Dong Q; Yu J-T -
Accelerated functional brain aging in pre-clinical familial Alzheimer's disease.
Nat Commun Volume: 12 Page(s): 5346
09/09/2021 Authors: Gonneaud J; Baria AT; Pichet Binette A; Gordon BA; Chhatwal JP; Cruchaga C; Jucker M; Levin J; Salloway S; Farlow M -
Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer's disease.
Alzheimers Res Ther Volume: 13 Page(s): 149
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Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease.
Nat Commun Volume: 12 Page(s): 4862
08/05/2021 Authors: Vogel JW; Iturria-Medina Y; Strandberg OT; Smith R; Levitis E; Evans AC; Hansson O; Alzheimers Disease Neuroimaging Initiative; Swedish BioFinder Study -
Correlation between Alzheimer's disease and type 2 diabetes using non-negative matrix factorization.
Sci Rep Volume: 11 Page(s): 15265
07/27/2021 Authors: Chung Y; Lee H; the Alzheimers Disease Neuroimaging Initiative -
A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.
Nat Med Volume: 27 Page(s): 1187 - 1196
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Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease.
Nat Commun Volume: 12 Page(s): 4001
06/28/2021 Authors: Hu WT; Ozturk T; Kollhoff A; Wharton W; Christina Howell J; Alzheimers Disease Neuroimaging Initiative -
KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.
Nat Commun Volume: 12 Page(s): 3825
06/22/2021 Authors: Neitzel J; Franzmeier N; Rubinski A; Dichgans M; Brendel M; Alzheimers Disease Neuroimaging Initiative (ADNI); Malik R; Ewers M -
Brain proteome-wide association study implicates novel proteins in depression pathogenesis.
Nat Neurosci Volume: 24 Page(s): 810 - 817
06/01/2021 Authors: Wingo TS; Liu Y; Gerasimov ES; Gockley J; Logsdon BA; Duong DM; Dammer EB; Lori A; Kim PJ; Ressler KJ -
Extracellular signal-regulated kinase regulates microglial immune responses in Alzheimer's disease.
J Neurosci Res Volume: 99 Page(s): 1704 - 1721
06/01/2021 Authors: Chen MJ; Ramesha S; Weinstock LD; Gao T; Ping L; Xiao H; Dammer EB; Duong DD; Levey AI; Lah JJ -
Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease.
Alzheimers Dement Volume: 17 Page(s): 984 - 1004
06/01/2021 Authors: Li H-D; Funk CC; McFarland K; Dammer EB; Allen M; Carrasquillo MM; Levites Y; Chakrabarty P; Burgess JD; Wang X -
Correction to: Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease.
Alzheimers Res Ther Volume: 13 Page(s): 102
05/18/2021 Authors: Donovan LE; Dammer EB; Duong DM; Hanfelt JJ; Levey AI; Seyfried NT; Lah JJ -
Four distinct trajectories of tau deposition identified in Alzheimer's disease.
Nat Med Volume: 27 Page(s): 871 - 881
05/01/2021 Authors: Vogel JW; Young AL; Oxtoby NP; Smith R; Ossenkoppele R; Strandberg OT; La Joie R; Aksman LM; Grothe MJ; Iturria-Medina Y -
The oral microbiome and inflammation in mild cognitive impairment.
Exp Gerontol Volume: 147 Page(s): 111273
05/01/2021 Authors: Yang I; Arthur RA; Zhao L; Clark J; Hu Y; Corwin EJ; Lah J -
Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease.
Brain Connect Volume: 11 Page(s): 239 - 249
04/01/2021 Authors: Smith RX; Strain JF; Tanenbaum A; Fagan AM; Hassenstab J; McDade E; Schindler SE; Gordon BA; Xiong C; Chhatwal J -
Genetic control of the human brain proteome.
Am J Hum Genet Volume: 108 Page(s): 400 - 410
03/04/2021 Authors: Robins C; Liu Y; Fan W; Duong DM; Meigs J; Harerimana NV; Gerasimov ES; Dammer EB; Cutler DJ; Beach TG -
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis.
Nat Genet Volume: 53 Page(s): 143 - 146
02/01/2021 Authors: Wingo AP; Liu Y; Gerasimov ES; Gockley J; Logsdon BA; Duong DM; Dammer EB; Robins C; Beach TG; Reiman EM -
Association of Initial -Amyloid Levels With Subsequent Flortaucipir Positron Emission Tomography Changes in Persons Without Cognitive Impairment.
JAMA Neurol Volume: 78 Page(s): 217 - 228
02/01/2021 Authors: Knopman DS; Lundt ES; Therneau TM; Albertson SM; Gunter JL; Senjem ML; Schwarz CG; Mielke MM; Machulda MM; Boeve BF -
Feasibility study for detection of retinal amyloid in clinical trials: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial.
Alzheimers Dement (Amst) Volume: 13 Page(s): e12199
01/01/2021 Authors: Ngolab J; Donohue M; Belsha A; Salazar J; Cohen P; Jaiswal S; Tan V; Gessert D; Korouri S; Aggarwal NT -
A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer's disease.
Alzheimers Dement (N Y) Volume: 7 Page(s): e12178
01/01/2021 Authors: He Q; Colon-Motas KM; Pybus AF; Piendel L; Seppa JK; Walker ML; Manzanares CM; Qiu D; Miocinovic S; Wood LB -
TBK1 interacts with tau and enhances neurodegeneration in tauopathy.
J Biol Chem Volume: 296 Page(s): 100760
01/01/2021 Authors: Abreha MH; Ojelade S; Dammer EB; McEachin ZT; Duong DM; Gearing M; Bassell GJ; Lah JJ; Levey AI; Shulman JM -
Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer's Disease.
Front Mol Neurosci Volume: 14 Page(s): 623659
01/01/2021 Authors: Guo Q; Dammer EB; Zhou M; Kundinger SR; Gearing M; Lah JJ; Levey AI; Shulman JM; Seyfried NT -
Deep Convolutional Neural Networks and Transfer Learning for Measuring Cognitive Impairment Using Eye-Tracking in a Distributed Tablet-Based Environment.
IEEE Trans Biomed Eng Volume: 68 Page(s): 11 - 18
01/01/2021 Authors: Haque RU; Pongos AL; Manzanares CM; Lah JJ; Levey AI; Clifford GD -
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions.
Sci Data Volume: 7 Page(s): 340
10/12/2020 Authors: Sieberts SK; Perumal TM; Carrasquillo MM; Allen M; Reddy JS; Hoffman GE; Dang KK; Calley J; Ebert PJ; Eddy J -
Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration.
Mol Neurodegener Volume: 15 Page(s): 57
10/08/2020 Authors: Franzmeier N; Surez-Calvet M; Frontzkowski L; Moore A; Hohman TJ; Morenas-Rodriguez E; Nuscher B; Shaw L; Trojanowski JQ; Dichgans M -
Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease.
Sci Adv Volume: 6
10/01/2020 Authors: Higginbotham L; Ping L; Dammer EB; Duong DM; Zhou M; Gearing M; Hurst C; Glass JD; Factor SA; Johnson ECB -
DIAN-TU Alzheimer's Disease Prevention Trial of Solanezumab and Gantenerumab: Amyloid, Tau and Neurodegeneration Outcomes
Volume: 88 Page(s): S103 - S103
10/01/2020 Authors: Bateman R; Aschenbrenner A; Benzinger T; Clifford D; Cruchaga C; Fagan A; Farlow M; Goate A; Gordon B; Hassenstab J -
Gamma Sensory Flicker for Patients with Prodromal Alzheimer's Disease: A Phase I Trial
Volume: 88 Page(s): S96 - S96
10/01/2020 Authors: He Q; Colon-Motas K; Pybus A; Pendel L; Seppa J; Walker M; Manzanares C; Qui D; Miocinovic S; Wood L -
Deep Proteomic Analysis of Alzheimer Disease Brain Identifies New Protein Co-Expression Modules Associated with Disease That are Not Observed at the RNA Level
Volume: 88 Page(s): S96 - S96
10/01/2020 Authors: Johnson ECB; Dammer EB; Carter EK; Duong DM; Ping L; Yin L; Lah JJ; Levey AI; Seyfried NT -
Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer's disease.
Sci Data Volume: 7 Page(s): 315
09/28/2020 Authors: Ping L; Kundinger SR; Duong DM; Yin L; Gearing M; Lah JJ; Levey AI; Seyfried NT -
Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
Nat Commun Volume: 11 Page(s): 3942
08/07/2020 Authors: Beckmann ND; Lin W-J; Wang M; Cohain AT; Charney AW; Wang P; Ma W; Wang Y-C; Jiang C; Audrain M -
Publisher Correction: Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain.
Nat Neurosci Volume: 23 Page(s): 1034
08/01/2020 Authors: Wingo AP; Fan W; Duong DM; Gerasimov ES; Dammer EB; Liu Y; Harerimana NV; White B; Thambisetty M; Troncoso JC -
A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer's disease.
Sci Rep Volume: 10 Page(s): 12063
07/21/2020 Authors: Squillario M; Abate G; Tomasi F; Tozzo V; Barla A; Uberti D; Alzheimers Disease Neuroimaging Initiative -
Author Correction: Multimodal hippocampal subfield grading for Alzheimer's disease classification.
Sci Rep Volume: 10 Page(s): 10969
06/30/2020 Authors: Hett K; Ta V-T; Catheline G; Tourdias T; Manjn JV; Coup P; Alzheimers Disease Neuroimaging Initiative -
Identification of Conserved Proteomic Networks in Neurodegenerative Dementia.
Cell Rep Volume: 31 Page(s): 107807
06/23/2020 Authors: Swarup V; Chang TS; Duong DM; Dammer EB; Dai J; Lah JJ; Johnson ECB; Seyfried NT; Levey AI; Geschwind DH -
Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain.
Nat Neurosci Volume: 23 Page(s): 696 - 700
06/01/2020 Authors: Wingo AP; Fan W; Duong DM; Gerasimov ES; Dammer EB; Liu Y; Harerimana NV; White B; Thambisetty M; Troncoso JC -
Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease.
Nat Commun Volume: 11 Page(s): 2612
05/26/2020 Authors: Vogel JW; Iturria-Medina Y; Strandberg OT; Smith R; Levitis E; Evans AC; Hansson O; Alzheimers Disease Neuroimaging Initiative; Swedish BioFinder Study -
Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease.
Mol Neurodegener Volume: 15 Page(s): 28
05/07/2020 Authors: Rayaprolu S; Gao T; Xiao H; Ramesha S; Weinstock LD; Shah J; Duong DM; Dammer EB; Webster JA; Lah JJ -
Functional Analyses of Genetic Risk Variants of Depression-Related Phenotypes in the Human Brain
Volume: 87 Page(s): S174 - S175
05/01/2020 Authors: Harerimana N; Liu Y; Gerasimov ES; Robins C; Duong DM; Lah JJ; Bennett DA; Levey AI; Seyfried NT; Wingo TS -
Human Brain Proteome-Wide Association Study of Depression Identified 24 Proteins as Tractable Targets for Further Mechanistic Studies
Volume: 87 Page(s): S183 - S183
05/01/2020 Authors: Wingo TS; Liu Y; Lori A; Gerasimov ES; Duong DM; Dammer E; Ressler K; Lah J; Bennett D; Seyfried NT -
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation.
Nat Med Volume: 26 Page(s): 769 - 780
05/01/2020 Authors: Johnson ECB; Dammer EB; Duong DM; Ping L; Zhou M; Yin L; Higginbotham LA; Guajardo A; White B; Troncoso JC -
Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer's Pathophysiology.
Sci Rep Volume: 10 Page(s): 2975
02/19/2020 Authors: Shen X; Ma S; Vemuri P; Simon G; Alzheimers Disease Neuroimaging Initiative -
Purpose in life is a robust protective factor of reported cognitive decline among late middle-aged adults: The Emory Healthy Aging Study.
J Affect Disord Volume: 263 Page(s): 310 - 317
02/15/2020 Authors: Wingo AP; Wingo TS; Fan W; Bergquist S; Alonso A; Marcus M; Levey AI; Lah JJ -
Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia.
NPJ Genom Med Volume: 5 Page(s): 6
02/06/2020 Authors: Wingo TS; Yang J; Fan W; Min Canon S; Gerasimov ES; Lori A; Logsdon B; Yao B; Seyfried NT; Lah JJ -
Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.
Nat Commun Volume: 11 Page(s): 667
02/03/2020 Authors: Reiman EM; Arboleda-Velasquez JF; Quiroz YT; Huentelman MJ; Beach TG; Caselli RJ; Chen Y; Su Y; Myers AJ; Hardy J -
FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.
Nat Commun Volume: 11 Page(s): 411
01/21/2020 Authors: Yan T; Liang J; Gao J; Wang L; Fujioka H; Alzheimer Disease Neuroimaging Initiative; Zhu X; Wang X -
Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease.
Nat Commun Volume: 11 Page(s): 347
01/17/2020 Authors: Franzmeier N; Neitzel J; Rubinski A; Smith R; Strandberg O; Ossenkoppele R; Hansson O; Ewers M; Alzheimers Disease Neuroimaging Initiative (ADNI) -
Targeted mass spectrometry to quantify brain-derived cerebrospinal fluid biomarkers in Alzheimer's disease.
Clin Proteomics Volume: 17 Page(s): 19
01/01/2020 Authors: Zhou M; Haque RU; Dammer EB; Duong DM; Ping L; Johnson ECB; Lah JJ; Levey AI; Seyfried NT -
Informed Consent in Two Alzheimer's Disease Research Centers: Insights From Research Coordinators.
AJOB Empir Bioeth Volume: 11 Page(s): 114 - 124
01/01/2020 Authors: Suver CM; Hamann JK; Chin EM; Goldstein FC; Blazel HM; Manzanares CM; Doerr MJ; Asthana SJ; Mangravite LM; Levey AI -
Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia.
NPJ Genom Med Volume: 5 Page(s): 6
01/01/2020 Authors: Wingo TS; Yang J; Fan W; Min Canon S; Gerasimov ES; Lori A; Logsdon B; Yao B; Seyfried NT; Lah JJ -
A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer's Disease Data.
Sci Rep Volume: 9 Page(s): 19589
12/20/2019 Authors: Kundu S; Lukemire J; Wang Y; Guo Y; Alzheimers Disease Neuroimaging Initiative -
Can Persons with Dementia Meaningfully Participate in Advance Care Planning Discussions? A Mixed-Methods Study of SPIRIT.
J Palliat Med Volume: 22 Page(s): 1410 - 1416
11/01/2019 Authors: Song M-K; Ward SE; Hepburn K; Paul S; Kim H; Shah RC; Morhardt DJ; Medders L; Lah JJ; Clevenger CC -
Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.
Sci Rep Volume: 9 Page(s): 14498
10/10/2019 Authors: Horgusluoglu-Moloch E; Risacher SL; Crane PK; Hibar D; Thompson PM; Saykin AJ; Nho K; Alzheimers Disease Neuroimaging Initiative (ADNI) -
Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease.
Cell Rep Volume: 29 Page(s): 301 - 316.e10
10/08/2019 Authors: Hsieh Y-C; Guo C; Yalamanchili HK; Abreha M; Al-Ouran R; Li Y; Dammer EB; Lah JJ; Levey AI; Bennett DA -
A Consensus Alzheimer's Disease Brain Protein Co-Expression Network Identifies Robust Biological Alterations Associated with Early- And Late-Stage Disease
Volume: 86 Page(s): S242 - S242
10/01/2019 Authors: Johnson ECB; Dammer EB; Duong DM; Yin L; Betarbet R; Shulman JM; Lah JJ; Levey AI; Seyfried NT -
Multimodal Hippocampal Subfield Grading For Alzheimer's Disease Classification.
Sci Rep Volume: 9 Page(s): 13845
09/25/2019 Authors: Hett K; Ta V-T; Catheline G; Tourdias T; Manjn JV; Coup P; Alzheimers Disease Neuroimaging Initiative -
Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A, tau, immunity and lipid processing.
Nat Genet Volume: 51 Page(s): 1423 - 1424
09/01/2019 Authors: Kunkle BW; Grenier-Boley B; Sims R; Bis JC; Damotte V; Naj AC; Boland A; Vronskaya M; van der Lee SJ; Amlie-Wolf A -
Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.
JAMA Neurol Volume: 76 Page(s): 1099 - 1108
09/01/2019 Authors: Ma Y; Jun GR; Zhang X; Chung J; Naj AC; Chen Y; Bellenguez C; Hamilton-Nelson K; Martin ER; Kunkle BW -
Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer's Disease.
Proteomes Volume: 7
08/27/2019 Authors: Higginbotham L; Dammer EB; Duong DM; Modeste E; Montine TJ; Lah JJ; Levey AI; Seyfried NT -
CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.
Aging Cell Volume: 18 Page(s): e12964
08/01/2019 Authors: Ma Y; Jun GR; Chung J; Zhang X; Kunkle BW; Naj AC; White CC; Bennett DA; De Jager PL; Alzheimers Disease Genetics Consortium -
Non-coding variability at the APOE locus contributes to the Alzheimer's risk.
Nat Commun Volume: 10 Page(s): 3310
07/25/2019 Authors: Zhou X; Chen Y; Mok KY; Kwok TCY; Mok VCT; Guo Q; Ip FC; Chen Y; Mullapudi N; Alzheimers Disease Neuroimaging Initiative -
Regional Amyloid- Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia.
Mol Neurobiol Volume: 56 Page(s): 4916 - 4924
07/01/2019 Authors: Schilling LP; Pascoal TA; Zimmer ER; Mathotaarachchi S; Shin M; de Mello Rieder CR; Gauthier S; Palmini A; Rosa-Neto P; Alzheimers Disease Neuroimaging Initiative -
Association of Early-Onset Alzheimer Disease With Elevated Low-Density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB.
JAMA Neurol Volume: 76 Page(s): 809 - 817
07/01/2019 Authors: Wingo TS; Cutler DJ; Wingo AP; Le N-A; Rabinovici GD; Miller BL; Lah JJ; Levey AI -
Mass Spectrometry-Based Quantification of Tau in Human Cerebrospinal Fluid Using a Complementary Tryptic Peptide Standard.
J Proteome Res Volume: 18 Page(s): 2422 - 2432
06/07/2019 Authors: Zhou M; Duong DM; Johnson ECB; Dai J; Lah JJ; Levey AI; Seyfried NT -
Human Brain Proteome-Wide Association Study of Longitudinally Assessed Late-Life Depression
Volume: 85 Page(s): S249 - S249
05/15/2019 Authors: Wingo A; Fan W; Seyfried N; Duc D; Dammer E; Bennett D; Lah J; Levey A; Wingo T -
The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory.
Nat Commun Volume: 10 Page(s): 1766
04/16/2019 Authors: Franzmeier N; Rubinski A; Neitzel J; Ewers M; Alzheimers Disease Neuroimaging Initiative (ADNI) -
Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age.
Nat Commun Volume: 10 Page(s): 1619
04/08/2019 Authors: Wingo AP; Dammer EB; Breen MS; Logsdon BA; Duong DM; Troncosco JC; Thambisetty M; Beach TG; Serrano GE; Reiman EM -
Proteomic analysis of the poly-ubiquitin profiles in Alzheimer's Disease
Volume: 33
04/01/2019 Authors: Zhang TT; Dammer EB; Abreha M; Duong DM; Lah JJ; Levey AI; Seyfried NT -
White matter in different regions evolves differently during progression to dementia.
Neurobiol Aging Volume: 76 Page(s): 71 - 79
04/01/2019 Authors: Dadar M; Maranzano J; Ducharme S; Collins DL; Alzheimer's Disease Neuroimaging Initiative -
Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers.
Brain Volume: 142 Page(s): 1063 - 1076
04/01/2019 Authors: Gordon BA; Blazey TM; Christensen J; Dincer A; Flores S; Keefe S; Chen C; Su Y; McDade EM; Wang G -
A blood-based signature of cerebrospinal fluid A1-42 status.
Sci Rep Volume: 9 Page(s): 4163
03/11/2019 Authors: Goudey B; Fung BJ; Schieber C; Faux NG; Alzheimers Disease Metabolomics Consortium; Alzheimers Disease Neuroimaging Initiative -
A statistical framework for cross-tissue transcriptome-wide association analysis.
Nat Genet Volume: 51 Page(s): 568 - 576
03/01/2019 Authors: Hu Y; Li M; Lu Q; Weng H; Wang J; Zekavat SM; Yu Z; Li B; Gu J; Muchnik S -
A concise and persistent feature to study brain resting-state network dynamics: Findings from the Alzheimer's Disease Neuroimaging Initiative.
Hum Brain Mapp Volume: 40 Page(s): 1062 - 1081
03/01/2019 Authors: Kuang L; Han X; Chen K; Caselli RJ; Reiman EM; Wang Y; Alzheimer's Disease Neuroimaging Initiative -
A Review of Statistical Methods in Imaging Genetics.
Can J Stat Volume: 47 Page(s): 108 - 131
03/01/2019 Authors: Nathoo FS; Kong L; Zhu H -
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A, tau, immunity and lipid processing.
Nat Genet Volume: 51 Page(s): 414 - 430
03/01/2019 Authors: Kunkle BW; Grenier-Boley B; Sims R; Bis JC; Damotte V; Naj AC; Boland A; Vronskaya M; van der Lee SJ; Amlie-Wolf A -
VisMET: a passive, efficient, and sensitive assessment of visuospatial memory in healthy aging, mild cognitive impairment, and Alzheimer's disease.
Learn Mem Volume: 26 Page(s): 93 - 100
03/01/2019 Authors: Haque RU; Manzanares CM; Brown LN; Pongos AL; Lah JJ; Clifford GD; Levey AI -
Type 2 diabetes mellitus, brain atrophy, and cognitive decline.
Neurology Volume: 92 Page(s): e823 - e830
02/19/2019 Authors: Moran C; Beare R; Wang W; Callisaya M; Srikanth V; Alzheimer's Disease Neuroimaging Initiative (ADNI) -
Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics.
Sci Rep Volume: 9 Page(s): 2235
02/19/2019 Authors: Varatharajah Y; Ramanan VK; Iyer R; Vemuri P; Alzheimers Disease Neuroimaging Initiative -
Association of CSF CD40 levels and synaptic degeneration across the Alzheimer's disease spectrum.
Neurosci Lett Volume: 694 Page(s): 41 - 45
02/16/2019 Authors: Ye X; Zhou W; Zhang J; for Alzheimers Disease Neuroimaging Initiative -
Predicting Alzheimer's disease progression using multi-modal deep learning approach.
Sci Rep Volume: 9 Page(s): 1952
02/13/2019 Authors: Lee G; Nho K; Kang B; Sohn K-A; Kim D; for Alzheimers Disease Neuroimaging Initiative -
Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs.
Neurobiol Aging Volume: 74 Page(s): 135 - 146
02/01/2019 Authors: Katsumata Y; Nelson PT; Estus S; Alzheimer's Disease Neuroimaging Initiative (ADNI); Fardo DW -
Amyloid beta-positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity.
Neurobiol Aging Volume: 74 Page(s): 191 - 201
02/01/2019 Authors: Avants BB; Hutchison RM; Mikulskis A; Salinas-Valenzuela C; Hargreaves R; Beaver J; Chiao P; Alzheimer's Disease Neuroimaging Initiative -
Functional signature of conversion of patients with mild cognitive impairment.
Neurobiol Aging Volume: 74 Page(s): 21 - 37
02/01/2019 Authors: Delli Pizzi S; Punzi M; Sensi SL; Alzheimer's Disease Neuroimaging Initiative -
QuickNAT: A fully convolutional network for quick and accurate segmentation of neuroanatomy.
Neuroimage Volume: 186 Page(s): 713 - 727
02/01/2019 Authors: Guha Roy A; Conjeti S; Navab N; Wachinger C; Alzheimer's Disease Neuroimaging Initiative -
Disease progression timeline estimation for Alzheimer's disease using discriminative event based modeling.
Neuroimage Volume: 186 Page(s): 518 - 532
02/01/2019 Authors: Venkatraghavan V; Bron EE; Niessen WJ; Klein S; Alzheimer's Disease Neuroimaging Initiative -
Accuracy and generalization capability of an automatic method for the detection of typical brain hypometabolism in prodromal Alzheimer disease.
Eur J Nucl Med Mol Imaging Volume: 46 Page(s): 334 - 347
02/01/2019 Authors: De Carli F; Nobili F; Pagani M; Bauckneht M; Massa F; Grazzini M; Jonsson C; Peira E; Morbelli S; Arnaldi D -
Accurate risk estimation of -amyloid positivity to identify prodromal Alzheimer's disease: Cross-validation study of practical algorithms.
Alzheimers Dement Volume: 15 Page(s): 194 - 204
02/01/2019 Authors: Palmqvist S; Insel PS; Zetterberg H; Blennow K; Brix B; Stomrud E; Alzheimer's Disease Neuroimaging Initiative; Swedish BioFINDER study; Mattsson N; Hansson O -
Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.
Alzheimers Dement Volume: 15 Page(s): 232 - 244
02/01/2019 Authors: Nho K; Kueider-Paisley A; MahmoudianDehkordi S; Arnold M; Risacher SL; Louie G; Blach C; Baillie R; Han X; Kastenmller G -
A Novel Method to Estimate Long-Term Chronological Changes From Fragmented Observations in Disease Progression.
Clin Pharmacol Ther Volume: 105 Page(s): 436 - 447
02/01/2019 Authors: Ishida T; Tokuda K; Hisaka A; Honma M; Kijima S; Takatoku H; Iwatsubo T; Moritoyo T; Suzuki H; Alzheimer's Disease Neuroimaging Initiative -
MAPT rs242557 variant is associated with hippocampus tau uptake on 18F-AV-1451 PET in non-demented elders.
Aging (Albany NY) Volume: 11 Page(s): 874 - 884
01/31/2019 Authors: Shen X-N; Miao D; Li J-Q; Tan C-C; Cao X-P; Tan L; Yu J-T -
Longitudinal Brain Atrophy Rates in Transient Ischemic Attack and Minor Ischemic Stroke Patients and Cognitive Profiles.
Front Neurol Volume: 10 Page(s): 18
01/01/2019 Authors: Munir M; Ursenbach J; Reid M; Gupta Sah R; Wang M; Sitaram A; Aftab A; Tariq S; Zamboni G; Griffanti L -
Diffusion MRI Indices and Their Relation to Cognitive Impairment in Brain Aging: The Updated Multi-protocol Approach in ADNI3.
Front Neuroinform Volume: 13 Page(s): 2
01/01/2019 Authors: Zavaliangos-Petropulu A; Nir TM; Thomopoulos SI; Reid RI; Bernstein MA; Borowski B; Jack CR; Weiner MW; Jahanshad N; Thompson PM -
A Homolog for Dementia Case Finding with Replication in the Alzheimer's Disease Neuroimaging Initiative.
J Alzheimers Dis Volume: 67 Page(s): 67 - 79
01/01/2019 Authors: Royall DR; Palmer RF; Alzheimers Disease Neuroimaging Initiative -
Next Generation Sequencing Analysis in Early Onset Dementia Patients.
J Alzheimers Dis Volume: 67 Page(s): 243 - 256
01/01/2019 Authors: Bonvicini C; Scassellati C; Benussi L; Di Maria E; Maj C; Ciani M; Fostinelli S; Mega A; Bocchetta M; Lanzi G -
Random forest prediction of Alzheimer's disease using pairwise selection from time series data.
PLoS One Volume: 14 Page(s): e0211558
01/01/2019 Authors: Moore PJ; Lyons TJ; Gallacher J; Alzheimers Disease Neuroimaging Initiative -
The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE 4 in Mild Cognitive Impairment.
Front Aging Neurosci Volume: 11 Page(s): 36
01/01/2019 Authors: Wang X; Zhou W; Ye T; Lin X; Zhang J; Alzheimers Disease Neuroimaging Initiative -
Longitudinal Functional Brain Mapping in Supernormals.
Cereb Cortex Volume: 29 Page(s): 242 - 252
01/01/2019 Authors: Wang X; Ren P; Baran TM; Raizada RDS; Mapstone M; Lin F; Alzheimers Disease Neuroimaging Initiative -
Robust Motion Regression of Resting-State Data Using a Convolutional Neural Network Model.
Front Neurosci Volume: 13 Page(s): 169
01/01/2019 Authors: Yang Z; Zhuang X; Sreenivasan K; Mishra V; Cordes D; Alzheimers Disease Neuroimaging Initiative -
Evaluating trajectories of episodic memory in normal cognition and mild cognitive impairment: Results from ADNI.
PLoS One Volume: 14 Page(s): e0212435
01/01/2019 Authors: Ding X; Charnigo RJ; Schmitt FA; Kryscio RJ; Abner EL; Alzheimers Disease Neuroimaging Initiative -
Prognosis of conversion of mild cognitive impairment to Alzheimer's dementia by voxel-wise Cox regression based on FDG PET data.
Neuroimage Clin Volume: 21 Page(s): 101637
01/01/2019 Authors: Srensen A; Blazhenets G; Rcker G; Schiller F; Meyer PT; Frings L; Alzheimer's Disease Neuroimaging Initiative -
Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment.
Neuroimage Clin Volume: 21 Page(s): 101617
01/01/2019 Authors: Kulason S; Tward DJ; Brown T; Sicat CS; Liu C-F; Ratnanather JT; Younes L; Bakker A; Gallagher M; Albert M -
Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative.
Alzheimers Dement Volume: 15 Page(s): 106 - 152
01/01/2019 Authors: Veitch DP; Weiner MW; Aisen PS; Beckett LA; Cairns NJ; Green RC; Harvey D; Jack CR; Jagust W; Morris JC -
Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.
Alzheimers Dement Volume: 15 Page(s): 76 - 92
01/01/2019 Authors: MahmoudianDehkordi S; Arnold M; Nho K; Ahmad S; Jia W; Xie G; Louie G; Kueider-Paisley A; Moseley MA; Thompson JW -
The Feasibility of Measuring Gait in an Outpatient Cognitive Neurology Clinical Setting.
J Alzheimers Dis Volume: 71 Page(s): S51 - S55
01/01/2019 Authors: Nocera JR; Arsik I; Keskinocak P; Lepley-Flood A; Lah JJ; Levey AI; Esper GJ -
Rationale and Design of the Emory Healthy Aging and Emory Healthy Brain Studies.
Neuroepidemiology Volume: 53 Page(s): 187 - 200
01/01/2019 Authors: Goetz ME; Hanfelt JJ; John SE; Bergquist SH; Loring DW; Quyyumi A; Clifford GD; Vaccarino V; Goldstein F; Johnson Nd TM -
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
Nat Med Volume: 25 Page(s): 152 - 164
01/01/2019 Authors: Swarup V; Hinz FI; Rexach JE; Noguchi K-I; Toyoshiba H; Oda A; Hirai K; Sarkar A; Seyfried NT; Cheng C -
Sex-specific genetic predictors of Alzheimer's disease biomarkers.
Acta Neuropathol Volume: 136 Page(s): 857 - 872
12/01/2018 Authors: Deming Y; Dumitrescu L; Barnes LL; Thambisetty M; Kunkle B; Gifford KA; Bush WS; Chibnik LB; Mukherjee S; De Jager PL -
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference.
Nat Commun Volume: 9 Page(s): 4273
10/15/2018 Authors: Young AL; Marinescu RV; Oxtoby NP; Bocchetta M; Yong K; Firth NC; Cash DM; Thomas DL; Dick KM; Cardoso J -
Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease.
Mol Neurodegener Volume: 13 Page(s): 52
10/04/2018 Authors: Johnson ECB; Dammer EB; Duong DM; Yin L; Thambisetty M; Troncoso JC; Lah JJ; Levey AI; Seyfried NT -
Quantitative Proteomics of CSF and Plasma Reveals Candidate Biomarkers Linked to Immune-Related Pathways in Alzheimer's Disease
Volume: 84 Page(s): S64 - S65
10/01/2018 Authors: Duong DM; Lah JJ; Levey AI; Seyfried NT -
Proteomic Changes in Frontotemporal Lobar Degeneration Due to Microtubule Associated Protein Tau (MAPT) Mutations
Volume: 84 Page(s): S161 - S161
10/01/2018 Authors: Hales C; Duc D; Seyfried N; Webster J; Levey A; Lah J; Dammer E -
Improving Alzheimer's Disease Care for the Citizens of Georgia: The Georgia Memory Network
Volume: 84 Page(s): S69 - S69
10/01/2018 Authors: Hales C; Dillard R; Sudduth S; Medders L; Loring D; Hepburn K; Johnson T; Humberstone S; Levey A; Lah J -
Quantitative Proteomics of the Human Brain Reveals Proteins Associated with Cognitive Resilience
ANNALS OF NEUROLOGY Volume: 84 Page(s): S62 - S62
10/01/2018 Authors: Wingo AP; Dammer EB; Duc D; Breen M; Logsdon B; Yang J; Beach TG; Reiman E; Thambisetty M; Troncosco J -
Brain microRNAs Associated with Cognitive Resilience
Volume: 84 Page(s): S161 - S162
10/01/2018 Authors: Wingo AP; Perumal T; Yang H-S; Schneider JA; Jin P; Lah JJ; Levey A; Bennett DA; De Jager PL; Wingo TS -
A Search for Predictive AD Biomarkers: The Emory Healthy Brain Study
Volume: 84 Page(s): S170 - S170
10/01/2018 Authors: Lah JJ; Goetz ME; John S; Lewis LM; Lomba C; Bergquist SH; Clifford GD; Goldstein FC; Loring DW; Kuerston R -
Comprehensive Mapping of Alzheimer's Disease Brain Ubiquitin Pattern Revealed Novel Tau Ubiquitylation Sites
Volume: 84 Page(s): S65 - S65
10/01/2018 Authors: Abreha M; Dammer E; Ping L; Duc D; Gearing M; Lah J; Levey A; Seyfried N -
Effects of APOE Genotype on Protein Co-Expression in Alzheimer's Disease
Volume: 84 Page(s): S164 - S164
10/01/2018 Authors: Dammer EB; Dai J; Johnson ECB; Duong DM; Gearing M; Lah JJ; Levey AI; Wingo TS; Seyfried NT -
Establishing a Roadmap for Brain-Based Protein Biomarkers in Alzheimer's Disease
Volume: 84 Page(s): S165 - S166
10/01/2018 Authors: Zhou M; Duong DM; Ping L; Dammer EB; Gearing M; Lah JJ; Levey AI; Seyfried NT -
Deep Proteomic Network Analysis of AD Brain Reveals Alterations in RNA Binding Proteins and RNA Splicing Associated with Disease
Volume: 84 Page(s): S68 - S68
10/01/2018 Authors: Johnson E; Dammer E; Duc D; Thambisetty M; Troncoso J; Lah J; Levey A; Seyfried N -
The Role of the Inflammation Module Hub Protein Moesin in AD
Volume: 84 Page(s): S160 - S160
10/01/2018 Authors: Betarbet R; Raza SA; Webster J; Eric DB; Duong D; Seyfried NT; Levey AI; Rangaraju S; Lah JJ -
Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease.
Proteomics Volume: 18 Page(s): e1800108
10/01/2018 Authors: Abreha MH; Dammer EB; Ping L; Zhang T; Duong DM; Gearing M; Lah JJ; Levey AI; Seyfried NT -
Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer's disease.
Sci Rep Volume: 8 Page(s): 13807
09/14/2018 Authors: Huang S-Y; Hsu J-L; Lin K-J; Liu H-L; Wey S-P; Hsiao I-T; Alzheimers Disease Neuroimaging Initiative -
The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease.
Sci Data Volume: 5 Page(s): 180185
09/11/2018 Authors: Wang M; Beckmann ND; Roussos P; Wang E; Zhou X; Wang Q; Ming C; Neff R; Ma W; Fullard JF -
Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center.
Neurobiol Dis Volume: 117 Page(s): 62 - 71
09/01/2018 Authors: Hanfelt JJ; Peng L; Goldstein FC; Lah JJ -
Medical Image Imputation from Image Collections.
IEEE Trans Med Imaging
08/22/2018 Authors: Dalca AV; Bouman KL; Freeman WT; Rost NS; Sabuncu MR; Golland P -
Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau.
JAMA Neurol Volume: 75 Page(s): 989 - 998
08/01/2018 Authors: Hohman TJ; Dumitrescu L; Barnes LL; Thambisetty M; Beecham G; Kunkle B; Gifford KA; Bush WS; Chibnik LB; Mukherjee S -
RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.
J Biol Chem Volume: 293 Page(s): 11047 - 11066
07/13/2018 Authors: Bishof I; Dammer EB; Duong DM; Kundinger SR; Gearing M; Lah JJ; Levey AI; Seyfried NT -
Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins.
Mol Neurodegener Volume: 13 Page(s): 34
06/28/2018 Authors: Rangaraju S; Dammer EB; Raza SA; Gao T; Xiao H; Betarbet R; Duong DM; Webster JA; Hales CM; Lah JJ -
Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.
Mol Neurodegener Volume: 13 Page(s): 24
05/21/2018 Authors: Rangaraju S; Dammer EB; Raza SA; Rathakrishnan P; Xiao H; Gao T; Duong DM; Pennington MW; Lah JJ; Seyfried NT -
Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images.
Sci Rep Volume: 8 Page(s): 5697
04/09/2018 Authors: Lu D; Popuri K; Ding GW; Balachandar R; Beg MF; Alzheimers Disease Neuroimaging Initiative -
18F-florbetapir Positron Emission Tomography-determined Cerebral -Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.
Anesthesiology Volume: 128 Page(s): 728 - 744
04/01/2018 Authors: Klinger RY; James OG; Borges-Neto S; Bisanar T; Li Y-J; Qi W; Berger M; Terrando N; Newman MF; Doraiswamy PM -
Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's Disease.
Sci Data Volume: 5 Page(s): 180036
03/13/2018 Authors: Ping L; Duong DM; Yin L; Gearing M; Lah JJ; Levey AI; Seyfried NT -
Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states.
Sci Rep Volume: 8 Page(s): 4103
03/07/2018 Authors: Mahjoub I; Mahjoub MA; Rekik I; Alzheimers Disease Neuroimaging Initiative -
Evidence for brain glucose dysregulation in Alzheimer's disease.
Alzheimers Dement Volume: 14 Page(s): 318 - 329
03/01/2018 Authors: An Y; Varma VR; Varma S; Casanova R; Dammer E; Pletnikova O; Chia CW; Egan JM; Ferrucci L; Troncoso J -
Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases.
Alzheimers Dement Volume: 14 Page(s): 352 - 366
03/01/2018 Authors: Allen M; Wang X; Burgess JD; Watzlawik J; Serie DJ; Younkin CS; Nguyen T; Malphrus KG; Lincoln S; Carrasquillo MM -
The Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): study protocol for a randomized controlled trial.
Trials Volume: 19 Page(s): 46
01/18/2018 Authors: Scherer RW; Drye L; Mintzer J; Lanctt K; Rosenberg P; Herrmann N; Padala P; Brawman-Mintzer O; Burke W; Craft S -
Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.
J Neurosci Volume: 38 Page(s): 74 - 92
01/03/2018 Authors: Chalermpalanupap T; Schroeder JP; Rorabaugh JM; Liles LC; Lah JJ; Levey AI; Weinshenker D -
Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes-Activation and Age-Related Effects.
Front Immunol Volume: 9 Page(s): 405
01/01/2018 Authors: Rangaraju S; Raza SA; Li NX; Betarbet R; Dammer EB; Duong D; Lah JJ; Seyfried NT; Levey AI -
Dual-Model Radiomic Biomarkers Predict Development of Mild Cognitive Impairment Progression to Alzheimer's Disease.
Front Neurosci Volume: 12 Page(s): 1045
01/01/2018 Authors: Zhou H; Jiang J; Lu J; Wang M; Zhang H; Zuo C; Alzheimers Disease Neuroimaging Initiative -
Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease.
Front Mol Neurosci Volume: 11 Page(s): 454
01/01/2018 Authors: Dai J; Johnson ECB; Dammer EB; Duong DM; Gearing M; Lah JJ; Levey AI; Wingo TS; Seyfried NT -
A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain.
EMBO Mol Med Volume: 10 Page(s): 48 - 62
01/01/2018 Authors: Umoh ME; Dammer EB; Dai J; Duong DM; Lah JJ; Levey AI; Gearing M; Glass JD; Seyfried NT -
Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.
J Neuropathol Exp Neurol Volume: 77 Page(s): 40 - 49
01/01/2018 Authors: Cherry JD; Zeineddin A; Dammer EB; Webster JA; Duong D; Seyfried NT; Levey AI; Alvarez VE; Huber BR; Stein TD -
Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease.
Alzheimers Dement (Amst) Volume: 10 Page(s): 595 - 598
01/01/2018 Authors: Peloso GM; van der Lee SJ; International Genomics of Alzheimer's Project (IGAP); Destefano AL; Seshardi S -
Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease.
Mol Neurodegener Volume: 12 Page(s): 82
11/06/2017 Authors: McKenzie AT; Moyon S; Wang M; Katsyv I; Song W-M; Zhou X; Dammer EB; Duong DM; Aaker J; Zhao Y -
Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty.
Sci Rep Volume: 7 Page(s): 14052
10/25/2017 Authors: Du L; Liu K; Yao X; Yan J; Risacher SL; Han J; Guo L; Saykin AJ; Shen L; Alzheimers Disease Neuroimaging Initiative -
Systems Pharmacology Approach to Identify Novel Kv1.3 Channel Dependent Mechanisms in Microglial Activation
Volume: 82 Page(s): S30 - S30
10/01/2017 Authors: Raza SA; Deng Q; Dammer EB; Duong D; Tansey MG; Lah JJ; Betarbet R; Seyfried NT; Levey AI; Rangaraju S -
Early-Onset Alzheimer's Disease Is Associated with APOB and Higher Plasma Cholesterol Independent of APOE
Volume: 82 Page(s): S53 - S53
10/01/2017 Authors: Wingo TS; Cutler DJ; Wingo AP; Le N-A; Rabinovici GD; Miller BL; Lah JJ; Levey AI -
Targeting Microglial and Macrophage Kv1.3 Potassium Channels as a Therapeutic Strategy in Alzheimer's Disease
Volume: 82 Page(s): S50 - S51
10/01/2017 Authors: Rangaraju S; Raza SA; Lah JJ; Tansey M; Levey AI -
Targeting Microglial and Macrophage Kv1.3 Potassium Channels as a Therapeutic Strategy in Alzheimer's Disease
Volume: 82 Page(s): S212 - S213
10/01/2017 Authors: Rangaraju S; Raza SA; Tansey MG; Lah JJ; Levey AI -
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Nat Genet Volume: 49 Page(s): 1373 - 1384
09/01/2017 Authors: Sims R; van der Lee SJ; Naj AC; Bellenguez C; Badarinarayan N; Jakobsdottir J; Kunkle BW; Boland A; Raybould R; Bis JC -
Integrating Next-Generation Genomic Sequencing and Mass Spectrometry To Estimate Allele-Specific Protein Abundance in Human Brain.
J Proteome Res Volume: 16 Page(s): 3336 - 3347
09/01/2017 Authors: Wingo TS; Duong DM; Zhou M; Dammer EB; Wu H; Cutler DJ; Lah JJ; Levey AI; Seyfried NT -
Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features.
Sci Rep Volume: 7 Page(s): 8137
08/15/2017 Authors: Singanamalli A; Wang H; Madabhushi A; Alzheimers Disease Neuroimaging Initiative -
Transethnic genome-wide scan identifies novel Alzheimer's disease loci.
Alzheimers Dement Volume: 13 Page(s): 727 - 738
07/01/2017 Authors: Jun GR; Chung J; Mez J; Barber R; Beecham GW; Bennett DA; Buxbaum JD; Byrd GS; Carrasquillo MM; Crane PK -
A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation.
J Neuroinflammation Volume: 14 Page(s): 128
06/26/2017 Authors: Rangaraju S; Raza SA; Pennati A; Deng Q; Dammer EB; Duong D; Pennington MW; Tansey MG; Lah JJ; Betarbet R -
Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease.
JAMA Neurol Volume: 74 Page(s): 557 - 566
05/01/2017 Authors: Mattsson N; Andreasson U; Zetterberg H; Blennow K; Alzheimers Disease Neuroimaging Initiative -
Comparison of detergent-insoluble proteome changes in autosomal dominant Alzheimer's disease brain to late onset AD and transgenic rodents
Volume: 88
04/18/2017 Authors: Hales C; Dammer E; Duong D; Gearing M; Cohen R; Wingo T; Lah J; Levey A; Seyfried N -
Association of AHA Cardiovascular Health Metrics With Cognitive Function, Depression, and Anxiety: The Emory Healthy Aging Study
Volume: 135
03/07/2017 Authors: Alonso A; Goldstein FC; Vaccarino V; Levey AI; Lah JJ; Marcus M -
Family History of Cardiovascular Disease is Associated With Cognitive Function: The Emory Healthy Aging Study
Volume: 135
03/07/2017 Authors: Goetz ME; Marcus M; Vaccarino V; Goldstein F; Levey A; Lah J -
A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Cell Syst Volume: 4 Page(s): 60 - 72.e4
01/25/2017 Authors: Seyfried NT; Dammer EB; Swarup V; Nandakumar D; Duong DM; Yin L; Deng Q; Nguyen T; Hales CM; Wingo T -
Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease.
Sci Rep Volume: 7 Page(s): 39880
01/12/2017 Authors: Huang M; Yang W; Feng Q; Chen W; Alzheimers Disease Neuroimaging Initiative -
Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.
Mol Psychiatry Volume: 22 Page(s): 13 - 23
01/01/2017 Authors: Varma VR; Varma S; An Y; Hohman TJ; Seddighi S; Casanova R; Beri A; Dammer EB; Seyfried NT; Pletnikova O -
Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression.
Proteomics Volume: 16 Page(s): 3042 - 3053
12/01/2016 Authors: Hales CM; Dammer EB; Deng Q; Duong DM; Gearing M; Troncoso JC; Thambisetty M; Lah JJ; Shulman JM; Levey AI -
A Genetic Study of a Large Pedigree with Late-Onset Alzheimer's Disease
Volume: 80 Page(s): S159 - S159
10/01/2016 Authors: Wingo TS; Cutler DJ; Lah JJ; Levey AI -
NADPH Dehydrogenase Quinone 1 (NQO1) Demonstrates Increased Expression and Pathologic Aggregation in Glial Cells in Chronic Traumatic Encephalopathy
Volume: 80 Page(s): S195 - S195
10/01/2016 Authors: Hales C; Zeineddin A; Webster J; Giuliano J; Duong D; Seyfried N; Dammer E; Mckee A; Levey A; Lah J -
Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention.
BMC Neurosci Volume: 17 Page(s): 46
07/07/2016 Authors: Agca C; Klakotskaia D; Schachtman TR; Chan AW; Lah JJ; Agca Y -
Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis.
Nat Commun Volume: 7 Page(s): 11934
06/21/2016 Authors: Iturria-Medina Y; Sotero RC; Toussaint PJ; Mateos-Prez JM; Evans AC; Alzheimers Disease Neuroimaging Initiative -
5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity.
Hum Mol Genet Volume: 25 Page(s): 2437 - 2450
06/15/2016 Authors: Bernstein AI; Lin Y; Street RC; Lin L; Dai Q; Yu L; Bao H; Gearing M; Lah JJ; Nelson PT -
Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults.
JAMA Neurol Volume: 73 Page(s): 721 - 732
06/01/2016 Authors: Risacher SL; McDonald BC; Tallman EF; West JD; Farlow MR; Unverzagt FW; Gao S; Boustani M; Crane PK; Petersen RC -
False-Positive Error Rates for Reliable Digit Span and Auditory Verbal Learning Test Performance Validity Measures in Amnestic Mild Cognitive Impairment and Early Alzheimer Disease.
Arch Clin Neuropsychol Volume: 31 Page(s): 313 - 331
06/01/2016 Authors: Loring DW; Goldstein FC; Chen C; Drane DL; Lah JJ; Zhao L; Larrabee GJ; Alzheimer's Disease Neuroimaging Initiative -
Assessment of the genetic variance of late-onset Alzheimer's disease.
Neurobiol Aging Volume: 41 Page(s): 200.e13 - 200.e20
05/01/2016 Authors: Ridge PG; Hoyt KB; Boehme K; Mukherjee S; Crane PK; Haines JL; Mayeux R; Farrer LA; Pericak-Vance MA; Schellenberg GD -
A Comparative Analysis of the Insoluble Brain Proteome in Alzheimer's Disease, Chronic Traumatic Encephalopathy and Frontotemporal Dementia
Volume: 86
04/05/2016 Authors: Hales C; Dammer E; Duong D; Webster J; Zeineddin A; Seyfried N; Lah J -
A Comparative Analysis of the Insoluble Brain Proteome in Alzheimer's Disease, Chronic Traumatic Encephalopathy and Frontotemporal Dementia
Volume: 86
04/05/2016 Authors: Hales C; Dammer E; Duc D; Webster J; Zeineddin A; Seyfried N; Lah J -
CSF complement 3 and factor H are staging biomarkers in Alzheimer's disease.
Acta Neuropathol Commun Volume: 4 Page(s): 14
02/17/2016 Authors: Hu WT; Watts KD; Tailor P; Nguyen TP; Howell JC; Lee RC; Seyfried NT; Gearing M; Hales CM; Levey AI -
A novel Alzheimer disease locus located near the gene encoding tau protein.
Mol Psychiatry Volume: 21 Page(s): 108 - 117
01/01/2016 Authors: Jun G; Ibrahim-Verbaas CA; Vronskaya M; Lambert J-C; Chung J; Naj AC; Kunkle BW; Wang L-S; Bis JC; Bellenguez C -
Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.
PLoS One Volume: 11 Page(s): e0148717
01/01/2016 Authors: Karch CM; Ezerskiy LA; Bertelsen S; Alzheimers Disease Genetics Consortium (ADGC); Goate AM -
Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses.
Alzheimers Dement Volume: 11 Page(s): 1439 - 1451
12/01/2015 Authors: Mukherjee S; Walter S; Kauwe JSK; Saykin AJ; Bennett DA; Larson EB; Crane PK; Glymour MM; Adult Changes in Thought Study Investigators; Religious Orders Study/Memory and Aging Project Investigators -
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.
PLoS Med Volume: 12 Page(s): e1001841
06/01/2015 Authors: stergaard SD; Mukherjee S; Sharp SJ; Proitsi P; Lotta LA; Day F; Perry JRB; Boehme KL; Walter S; Kauwe JS -
Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE.
Nat Commun Volume: 6 Page(s): 6760
05/19/2015 Authors: Ayton S; Faux NG; Bush AI; Alzheimer's Disease Neuroimaging Initiative -
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease.
Nat Genet Volume: 47 Page(s): 445 - 447
05/01/2015 Authors: Steinberg S; Stefansson H; Jonsson T; Johannsdottir H; Ingason A; Helgason H; Sulem P; Magnusson OT; Gudjonsson SA; Unnsteinsdottir U -
TREM2 is associated with increased risk for Alzheimer's disease in African Americans.
Mol Neurodegener Volume: 10 Page(s): 19
04/10/2015 Authors: Jin SC; Carrasquillo MM; Benitez BA; Skorupa T; Carrell D; Patel D; Lincoln S; Krishnan S; Kachadoorian M; Reitz C -
Tau phosphosignatures discriminate Alzheimer Disease from other tauopathies
FASEB JOURNAL Volume: 29
04/01/2015 Authors: Seyfried N; Dammer E; Ren R; Gearing M; Duc D; Lah J; Levey A -
Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
JAMA Neurol Volume: 72 Page(s): 209 - 216
02/01/2015 Authors: Wang L-S; Naj AC; Graham RR; Crane PK; Kunkle BW; Cruchaga C; Murcia JDG; Cannon-Albright L; Baldwin CT; Zetterberg H -
CSF beta-amyloid 1-42 - what are we measuring in Alzheimer's disease?
Ann Clin Transl Neurol Volume: 2 Page(s): 131 - 139
02/01/2015 Authors: Hu WT; Watts KD; Shaw LM; Howell JC; Trojanowski JQ; Basra S; Glass JD; Lah JJ; Levey AI -
Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins.
Proteomics Volume: 15 Page(s): 508 - 519
01/01/2015 Authors: Dammer EB; Lee AK; Duong DM; Gearing M; Lah JJ; Levey AI; Seyfried NT -
Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease.
J Biol Chem Volume: 289 Page(s): 35296 - 35313
12/19/2014 Authors: Diner I; Hales CM; Bishof I; Rabenold L; Duong DM; Yi H; Laur O; Gearing M; Troncoso J; Thambisetty M -
Late-stage CTE pathology in a retired soccer player with dementia.
Neurology Volume: 83 Page(s): 2307 - 2309
12/09/2014 Authors: Hales C; Neill S; Gearing M; Cooper D; Glass J; Lah J -
Integrated approaches for analyzing U1-70K cleavage in Alzheimer's disease.
J Proteome Res Volume: 13 Page(s): 4526 - 4534
11/07/2014 Authors: Bai B; Chen P-C; Hales CM; Wu Z; Pagala V; High AA; Levey AI; Lah JJ; Peng J -
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
JAMA Neurol Volume: 71 Page(s): 1394 - 1404
11/01/2014 Authors: Naj AC; Jun G; Reitz C; Kunkle BW; Perry W; Park YS; Beecham GW; Rajbhandary RA; Hamilton-Nelson KL; Wang L-S -
Small Nuclear Ribonucleoproteins (snRNPs) Aggregate in Chronic Traumatic Encephalopathy Suggesting Shared Mechanism with Alzheimer's Disease
Volume: 76 Page(s): S116 - S116
10/01/2014 Authors: Hales CM; Mckee AC; Levey AI; Lah JJ -
Aggregates of small nuclear ribonucleic acids (snRNAs) in Alzheimer's disease.
Brain Pathol Volume: 24 Page(s): 344 - 351
07/01/2014 Authors: Hales CM; Dammer EB; Diner I; Yi H; Seyfried NT; Gearing M; Glass JD; Montine TJ; Levey AI; Lah JJ -
U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21.
Mol Neurodegener Volume: 9 Page(s): 15
04/28/2014 Authors: Hales CM; Seyfried NT; Dammer EB; Duong D; Yi H; Gearing M; Troncoso JC; Mufson EJ; Thambisetty M; Levey AI -
Biomarkers for predicting cognitive decline in those with normal cognition.
J Alzheimers Dis Volume: 40 Page(s): 587 - 594
01/01/2014 Authors: Steenland K; Zhao L; Goldstein F; Cellar J; Lah J -
Pharmacologic inhibition of ROCK2 suppresses amyloid- production in an Alzheimer's disease mouse model.
J Neurosci Volume: 33 Page(s): 19086 - 19098
12/04/2013 Authors: Herskowitz JH; Feng Y; Mattheyses AL; Hales CM; Higginbotham LA; Duong DM; Montine TJ; Troncoso JC; Thambisetty M; Seyfried NT -
Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP.
Neurology Volume: 81 Page(s): 1945 - 1952
11/26/2013 Authors: Hu WT; Watts K; Grossman M; Glass J; Lah JJ; Hales C; Shelnutt M; Van Deerlin V; Trojanowski JQ; Levey AI -
AAV2 production with optimized N/P ratio and PEI-mediated transfection results in low toxicity and high titer for in vitro and in vivo applications.
J Virol Methods Volume: 193 Page(s): 270 - 277
11/01/2013 Authors: Huang X; Hartley A-V; Yin Y; Herskowitz JH; Lah JJ; Ressler KJ -
Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes.
J Neuropathol Exp Neurol Volume: 72 Page(s): 1009 - 1015
11/01/2013 Authors: Hales CM; Rees H; Seyfried NT; Dammer EB; Duong DM; Gearing M; Montine TJ; Troncoso JC; Thambisetty M; Levey AI -
U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.
Proc Natl Acad Sci U S A Volume: 110 Page(s): 16562 - 16567
10/08/2013 Authors: Bai B; Hales CM; Chen P-C; Gozal Y; Dammer EB; Fritz JJ; Wang X; Xia Q; Duong DM; Street C -
Neuron enriched nuclear proteome isolated from human brain.
J Proteome Res Volume: 12 Page(s): 3193 - 3206
07/05/2013 Authors: Dammer EB; Duong DM; Diner I; Gearing M; Feng Y; Lah JJ; Levey AI; Seyfried NT -
NF-B activity is inversely correlated to RNF11 expression in Parkinson's disease.
Neurosci Lett Volume: 547 Page(s): 16 - 20
06/28/2013 Authors: Pranski E; Van Sanford CD; Dalal N; Orr AL; Karmali D; Cooper DS; Gearing M; Lah JJ; Levey AI; Betarbet R -
RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-B signaling in dopaminergic cells.
Neurobiol Dis Volume: 54 Page(s): 264 - 279
06/01/2013 Authors: Pranski EL; Dalal NV; Sanford CV; Herskowitz JH; Gearing M; Lazo C; Miller GW; Lah JJ; Levey AI; Betarbet RS -
Proteomic analysis of postsynaptic density in Alzheimer's disease.
Clin Chim Acta Volume: 420 Page(s): 62 - 68
05/01/2013 Authors: Zhou J; Jones DR; Duong DM; Levey AI; Lah JJ; Peng J -
Novel CSF biomarkers for frontotemporal lobar degeneration with lesions immunoreactive to TDP-43 (FTLD-TDP)
Volume: 80 Page(s): E201 - E201
05/01/2013 Authors: Hu W; Watts K; Grossman M; Glass J; Lah J; Trojanowski J; Levey A -
A behavioral task predicts conversion to mild cognitive impairment and Alzheimer's disease.
Am J Alzheimers Dis Other Demen Volume: 28 Page(s): 179 - 184
03/01/2013 Authors: Zola SM; Manzanares CM; Clopton P; Lah JJ; Levey AI -
Variant of TREM2 associated with the risk of Alzheimer's disease.
N Engl J Med Volume: 368 Page(s): 107 - 116
01/10/2013 Authors: Jonsson T; Stefansson H; Steinberg S; Jonsdottir I; Jonsson PV; Snaedal J; Bjornsson S; Huttenlocher J; Levey AI; Lah JJ -
Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease.
Alzheimers Res Ther Volume: 5 Page(s): 32
01/01/2013 Authors: Donovan LE; Dammer EB; Duong DM; Hanfelt JJ; Levey AI; Seyfried NT; Lah JJ -
Behavior matters--cognitive predictors of survival in amyotrophic lateral sclerosis.
PLoS One Volume: 8 Page(s): e57584
01/01/2013 Authors: Hu WT; Shelnutt M; Wilson A; Yarab N; Kelly C; Grossman M; Libon DJ; Khan J; Lah JJ; Levey AI -
Clinical Tissue Proteomics Identifies the U1 Small Nuclear Ribonucleoprotein Complex in Alzheimer Disease Pathology
MOLECULAR BIOLOGY OF THE CELL Volume: 24
01/01/2013 Authors: Chen P-C; Bai B; Hales C; Gozal YM; Li Y; Dammer EB; Cantero G; Seyfried NT; Sun YE; Mufson EJ -
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
Nat Genet Volume: 44 Page(s): 1349 - 1354
12/01/2012 Authors: Whitcomb DC; LaRusch J; Krasinskas AM; Klei L; Smith JP; Brand RE; Neoptolemos JP; Lerch MM; Tector M; Sandhu BS -
Hippocampal proNGF signaling pathways and -amyloid levels in mild cognitive impairment and Alzheimer disease.
J Neuropathol Exp Neurol Volume: 71 Page(s): 1018 - 1029
11/01/2012 Authors: Mufson EJ; He B; Nadeem M; Perez SE; Counts SE; Leurgans S; Fritz J; Lah J; Ginsberg SD; Wuu J -
RNF11 modulates microglia activation through NF-B signalling cascade.
Neurosci Lett Volume: 528 Page(s): 174 - 179
10/24/2012 Authors: Dalal NV; Pranski EL; Tansey MG; Lah JJ; Levey AI; Betarbet RS -
Asparaginyl endopeptidase cleaves TDP-43 in brain.
Proteomics Volume: 12 Page(s): 2455 - 2463
08/01/2012 Authors: Herskowitz JH; Gozal YM; Duong DM; Dammer EB; Gearing M; Ye K; Lah JJ; Peng J; Levey AI; Seyfried NT -
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.
Hum Mol Genet Volume: 21 Page(s): 3500 - 3512
08/01/2012 Authors: Coppola G; Chinnathambi S; Lee JJ; Dombroski BA; Baker MC; Soto-Ortolaza AI; Lee SE; Klein E; Huang AY; Sears R -
GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid- production.
Mol Biol Cell Volume: 23 Page(s): 2645 - 2657
07/01/2012 Authors: Herskowitz JH; Offe K; Deshpande A; Kahn RA; Levey AI; Lah JJ -
Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.
Neurosci Lett Volume: 520 Page(s): 104 - 109
06/27/2012 Authors: Pranski EL; Van Sanford CD; Dalal NV; Orr AL; Karmali D; Cooper DS; Costa N; Heilman CJ; Gearing M; Lah JJ -
Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.
J Proteome Res Volume: 11 Page(s): 2721 - 2738
05/04/2012 Authors: Seyfried NT; Gozal YM; Donovan LE; Herskowitz JH; Dammer EB; Xia Q; Ku L; Chang J; Duong DM; Rees HD -
Neuronal RING finger protein 11 (RNF11) regulates canonical NF-B signaling.
J Neuroinflammation Volume: 9 Page(s): 67
04/16/2012 Authors: Pranski EL; Dalal NV; Herskowitz JH; Orr AL; Roesch LA; Fritz JJ; Heilman C; Lah JJ; Levey AI; Betarbet RS -
Cerebrospinal Fluid beta-Amyloid 1-42 Solubility Is Influenced by Apolipoproteins E and J
Volume: 78
04/01/2012 Authors: Hu W; Basra S; Watts K; Glass J; Lah J; Levey A -
Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease.
Proteomics Clin Appl Volume: 6 Page(s): 201 - 211
04/01/2012 Authors: Donovan LE; Higginbotham L; Dammer EB; Gearing M; Rees HD; Xia Q; Duong DM; Seyfried NT; Lah JJ; Levey AI -
Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.
Proc Natl Acad Sci U S A Volume: 109 Page(s): 3985 - 3990
03/06/2012 Authors: Bakken TE; Roddey JC; Djurovic S; Akshoomoff N; Amaral DG; Bloss CS; Casey BJ; Chang L; Ernst TM; Gruen JR -
Exogenous seeding of cerebral -amyloid deposition in APP-transgenic rats.
J Neurochem Volume: 120 Page(s): 660 - 666
03/01/2012 Authors: Rosen RF; Fritz JJ; Dooyema J; Cintron AF; Hamaguchi T; Lah JJ; LeVine H; Jucker M; Walker LC -
Neuronal LR11 expression does not differentiate between clinically-defined Alzheimer's disease and control brains.
PLoS One Volume: 7 Page(s): e40527
01/01/2012 Authors: Sager KL; Wuu J; Herskowitz JH; Mufson EJ; Levey AI; Lah JJ -
Gephyrin Plaques Identified in Frontal Cortex of Alzheimer's Disease Brains
Volume: 72 Page(s): S43 - S43
01/01/2012 Authors: Hales CM; Rees H; Lah JJ; Levey AI; Wingo T -
Autosomal recessive causes likely in early-onset Alzheimer disease.
Arch Neurol Volume: 69 Page(s): 59 - 64
01/01/2012 Authors: Wingo TS; Lah JJ; Levey AI; Cutler DJ -
Paraoxonase-1 polymorphisms in Alzheimer's disease, Parkinson's disease, and AD-PD spectrum diseases.
Neurobiol Aging Volume: 33 Page(s): 204.e13 - 204.e15
01/01/2012 Authors: Wingo TS; Rosen A; Cutler DJ; Lah JJ; Levey AI -
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.
PLoS One Volume: 7 Page(s): e38658
01/01/2012 Authors: Dammer EB; Fallini C; Gozal YM; Duong DM; Rossoll W; Xu P; Lah JJ; Levey AI; Peng J; Bassell GJ -
Neurocognitive correlates of nocturnal oxygen desaturation in a memory clinic population.
J Clin Exp Neuropsychol Volume: 34 Page(s): 325 - 332
01/01/2012 Authors: Yamout K; Goldstein FC; Lah JJ; Levey AI; Bliwise DL -
Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration.
Mol Neurodegener Volume: 6 Page(s): 82
11/29/2011 Authors: Gozal YM; Seyfried NT; Gearing M; Glass JD; Heilman CJ; Wuu J; Duong DM; Cheng D; Xia Q; Rees HD -
An exploration of subgroups of mild cognitive impairment based on cognitive, neuropsychiatric and functional features: analysis of data from the National Alzheimer's Coordinating Center.
Am J Geriatr Psychiatry Volume: 19 Page(s): 940 - 950
11/01/2011 Authors: Hanfelt JJ; Wuu J; Sollinger AB; Greenaway MC; Lah JJ; Levey AI; Goldstein FC -
DEMENTIA SCREENING IN PRIMARY CARE
JOURNAL OF GENERAL INTERNAL MEDICINE Volume: 26 Page(s): S10 - S10
05/01/2011 Authors: Brott BJ; Cellar JS; Lah JJ -
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Nat Genet Volume: 43 Page(s): 436 - 441
05/01/2011 Authors: Naj AC; Jun G; Beecham GW; Wang L-S; Vardarajan BN; Buros J; Gallins PJ; Buxbaum JD; Jarvik GP; Crane PK -
White matter hyperintensities and changes in white matter integrity in patients with Alzheimer's disease.
Neuroradiology Volume: 53 Page(s): 373 - 381
05/01/2011 Authors: Wang L; Goldstein FC; Levey AI; Lah JJ; Meltzer CC; Holder CA; Mao H -
Dementia Screening in Primary Care.
Volume: 59 Page(s): S49 - S50
04/01/2011 Authors: Brott B; Cellar J; Lah J -
Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease.
J Biol Chem Volume: 286 Page(s): 10457 - 10465
03/25/2011 Authors: Dammer EB; Na CH; Xu P; Seyfried NT; Duong DM; Cheng D; Gearing M; Rees H; Lah JJ; Levey AI -
Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production.
J Biol Chem Volume: 286 Page(s): 6117 - 6127
02/25/2011 Authors: Herskowitz JH; Seyfried NT; Gearing M; Kahn RA; Peng J; Levey AI; Lah JJ -
Proteomic analysis of hippocampal dentate granule cells in frontotemporal lobar degeneration: application of laser capture technology.
Front Neurol Volume: 2 Page(s): 24
01/01/2011 Authors: Gozal YM; Dammer EB; Duong DM; Cheng D; Gearing M; Rees HD; Peng J; Lah JJ; Levey AI -
Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration.
J Proteome Res Volume: 9 Page(s): 6368 - 6379
12/03/2010 Authors: Herskowitz JH; Seyfried NT; Duong DM; Xia Q; Rees HD; Gearing M; Peng J; Lah JJ; Levey AI -
Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated.
Mol Neurodegener Volume: 5 Page(s): 40
10/11/2010 Authors: Vieira SI; Rebelo S; Esselmann H; Wiltfang J; Lah J; Lane R; Small SA; Gandy S; da Cruz E Silva EF; da Cruz E Silva OA -
Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.
J Neurosci Volume: 30 Page(s): 13110 - 13115
09/29/2010 Authors: Lane RF; Raines SM; Steele JW; Ehrlich ME; Lah JA; Small SA; Tanzi RE; Attie AD; Gandy S -
Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation.
ACS Chem Neurosci Volume: 1 Page(s): 542 - 551
08/18/2010 Authors: Davis AA; Heilman CJ; Brady AE; Miller NR; Fuerstenau-Sharp M; Hanson BJ; Lindsley CW; Conn PJ; Lah JJ; Levey AI -
Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers.
Ann Neurol Volume: 68 Page(s): 220 - 230
08/01/2010 Authors: Gandy S; Simon AJ; Steele JW; Lublin AL; Lah JJ; Walker LC; Levey AI; Krafft GA; Levy E; Checler F -
Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains.
Mol Cell Proteomics Volume: 9 Page(s): 705 - 718
04/01/2010 Authors: Seyfried NT; Gozal YM; Dammer EB; Xia Q; Duong DM; Cheng D; Lah JJ; Levey AI; Peng J -
DHA diet reduces AD pathology in young APPswe/PS1 Delta E9 transgenic mice: possible gender effects.
J Neurosci Res Volume: 88 Page(s): 1026 - 1040
04/01/2010 Authors: Perez SE; Berg BM; Moore KA; He B; Counts SE; Fritz JJ; Hu Y-S; Lazarov O; Lah JJ; Mufson EJ -
Deletion of M1 muscarinic acetylcholine receptors increases amyloid pathology in vitro and in vivo.
J Neurosci Volume: 30 Page(s): 4190 - 4196
03/24/2010 Authors: Davis AA; Fritz JJ; Wess J; Lah JJ; Levey AI -
Mild cognitive impairment in Parkinson's disease: subtypes and motor characteristics.
Parkinsonism Relat Disord Volume: 16 Page(s): 177 - 180
03/01/2010 Authors: Sollinger AB; Goldstein FC; Lah JJ; Levey AI; Factor SA -
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.
Nat Genet Volume: 42 Page(s): 234 - 239
03/01/2010 Authors: Van Deerlin VM; Sleiman PMA; Martinez-Lage M; Chen-Plotkin A; Wang L-S; Graff-Radford NR; Dickson DW; Rademakers R; Boeve BF; Grossman M -
Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease.
Acta Neuropathol Volume: 119 Page(s): 221 - 233
02/01/2010 Authors: Rosen RF; Ciliax BJ; Wingo TS; Gearing M; Dooyema J; Lah JJ; Ghiso JA; LeVine H; Walker LC -
The impact of vascular comorbidities on qualitative error analysis of executive impairment in Alzheimer's disease.
J Int Neuropsychol Soc Volume: 16 Page(s): 77 - 83
01/01/2010 Authors: Lamar M; Libon DJ; Ashley AV; Lah JJ; Levey AI; Goldstein FC -
Prion-like induction of Alzheimer-type proteopathy in transgenic animals
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01/01/2010 Authors: Walker LC; Rosen RF; Fritz JJ; Betarbet R; Lah JJ; LeVine IIIH; Jucker M -
Analyses of diagnostic patterns at 30 Alzheimer's disease centers in the US.
Neuroepidemiology Volume: 35 Page(s): 19 - 27
01/01/2010 Authors: Steenland K; Macneil J; Bartell S; Lah J -
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.
J Neurosci Volume: 29 Page(s): 14271 - 14286
11/11/2009 Authors: Shirey JK; Brady AE; Jones PJ; Davis AA; Bridges TM; Kennedy JP; Jadhav SB; Menon UN; Xiang Z; Watson ML -
Proteomics analysis reveals novel components in the detergent-insoluble subproteome in Alzheimer's disease.
J Proteome Res Volume: 8 Page(s): 5069 - 5079
11/01/2009 Authors: Gozal YM; Duong DM; Gearing M; Cheng D; Hanfelt JJ; Funderburk C; Peng J; Lah JJ; Levey AI -
Is ApoE epsilon4 associated with cognitive functioning in African Americans diagnosed with Alzheimer Disease? An exploratory study.
South Med J Volume: 102 Page(s): 890 - 893
09/01/2009 Authors: Mount DL; Ashley AV; Lah JJ; Levey AI; Goldstein FC -
White Matter Integrity and Episodic Memory Performance in Mild Cognitive Impairment: A Diffusion Tensor Imaging Study.
Brain Imaging Behav Volume: 3 Page(s): 132 - 141
06/01/2009 Authors: Goldstein FC; Mao H; Wang L; Ni C; Lah JJ; Levey AI -
Alterations in cortical thickness and white matter integrity in mild cognitive impairment measured by whole-brain cortical thickness mapping and diffusion tensor imaging.
Volume: 30 Page(s): 893 - 899
05/01/2009 Authors: Wang L; Goldstein FC; Veledar E; Levey AI; Lah JJ; Meltzer CC; Holder CA; Mao H -
Non-Verbal Memory Performance is Associated with Conversion to Dementia Within 1 Year: A Prospective Study of MCI Using Computerized Cognitive Assessment
Volume: 57 Page(s): S194 - S195
03/01/2009 Authors: Dwolatzky T; Doniger GM; Goldstein FC; Simon ES; Levey AI; Lah J; Friger MD -
Non-Verbal Memory Performance is Associated with Conversion to Dementia Within 1 Year: A Prospective Study of MCI Using Computerized Cognitive Assessment
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY Volume: 17 Page(s): A71 - A72
03/01/2009 Authors: Simon ES; Dwolatzky T; Goldstein FC; Doniger GM; Levey AI; Lah JJ; Friger MD -
Neurobiology of Alzheimer's Disease
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01/01/2009 Authors: Davis AA; Lah JJ; Levey AI -
Eye tracking during a visual paired comparison task as a predictor of early dementia.
Am J Alzheimers Dis Other Demen Volume: 24 Page(s): 258 - 266
01/01/2009 Authors: Crutcher MD; Calhoun-Haney R; Manzanares CM; Lah JJ; Levey AI; Zola SM -
Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease.
J Neurosci Volume: 28 Page(s): 12877 - 12886
11/26/2008 Authors: Dodson SE; Andersen OM; Karmali V; Fritz JJ; Cheng D; Peng J; Levey AI; Willnow TE; Lah JJ -
Development of a rapid screening instrument for mild cognitive impairment and undiagnosed dementia.
J Alzheimers Dis Volume: 15 Page(s): 419 - 427
11/01/2008 Authors: Steenland NK; Auman CM; Patel PM; Bartell SM; Goldstein FC; Levey AI; Lah JJ -
Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.
J Neurosci Volume: 28 Page(s): 10422 - 10433
10/08/2008 Authors: Jones CK; Brady AE; Davis AA; Xiang Z; Bubser M; Tantawy MN; Kane AS; Bridges TM; Kennedy JP; Bradley SR -
Mild cognitive impairment in Parkinson's disease: Clinical and motor characteristics
Volume: 23 Page(s): 686 - 686
10/01/2008 Authors: Sollinger AB; Goldstein F; Lah J; Levey A; Factor S -
Fas-associated factor 1 and Parkinson's disease.
Neurobiol Dis Volume: 31 Page(s): 309 - 315
09/01/2008 Authors: Betarbet R; Anderson LR; Gearing M; Hodges TR; Fritz JJ; Lah JJ; Levey AI -
Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry.
J Proteome Res Volume: 7 Page(s): 2845 - 2851
07/01/2008 Authors: Xia Q; Cheng D; Duong DM; Gearing M; Lah JJ; Levey AI; Peng J -
Proteomic identification of novel proteins associated with Lewy bodies.
Front Biosci Volume: 13 Page(s): 3850 - 3856
05/01/2008 Authors: Xia Q; Liao L; Cheng D; Duong DM; Gearing M; Lah JJ; Levey AI; Peng J -
MEDI 253-Subtype-selective allosteric modulation of the M1 and M4 muscarinic receptors
Volume: 235
04/06/2008 Authors: Bridges TM; Jones CK; Brady A; Marlo JE; Rodriguez AL; Niswender CM; Sheffler D; Kennedy P; Williams R; Orton D -
A single nucleotide polymorphism (SNP) at DBH is associated with Alzheimer disease in European-American subjects
Volume: 63 Page(s): 92S - 92S
04/01/2008 Authors: Tang Y; Lah J; Rosen A; Levey A; Cubells JF -
Non-verbal memory performance is associated with conversion to dementia within 1 year: A prospective study of MCI using computerized cognitive assessment
Volume: 70 Page(s): A279 - A279
03/11/2008 Authors: Simon E; Dwolatzky T; Goldstein F; Doniger GM; Levey A; Lah J; Friger MD -
Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: transgene and endogenous APP genes are regulated tissue-specifically.
BMC Neurosci Volume: 9 Page(s): 28
02/26/2008 Authors: Agca C; Fritz JJ; Walker LC; Levey AI; Chan AW; Lah JJ; Agca Y -
Effects of hypertension and hypercholesterolemia on cognitive functioning in patients with alzheimer disease.
Alzheimer Dis Assoc Disord Volume: 22 Page(s): 336 - 342
01/01/2008 Authors: Goldstein FC; Ashley AV; Endeshaw YW; Hanfelt J; Lah JJ; Levey AI -
Cognitive performance and plasma levels of homocysteine, vitamin B12, folate and lipids in patients with Alzheimer disease.
Dement Geriatr Cogn Disord Volume: 26 Page(s): 384 - 390
01/01/2008 Authors: Li L; Cao D; Desmond R; Rahman A; Lah JJ; Levey AI; Zamrini E -
Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network.
Mol Biol Cell Volume: 19 Page(s): 51 - 64
01/01/2008 Authors: Shrivastava-Ranjan P; Faundez V; Fang G; Rees H; Lah JJ; Levey AI; Kahn RA -
Neuronal LR11/sorLA expression is reduced in mild cognitive impairment.
Ann Neurol Volume: 62 Page(s): 640 - 647
12/01/2007 Authors: Sager KL; Wuu J; Leurgans SE; Rees HD; Gearing M; Mufson EJ; Levey AI; Lah JJ -
Evidence of shared risk for Alzheimer's disease and Parkinson's disease using family history.
Neurogenetics Volume: 8 Page(s): 263 - 270
11/01/2007 Authors: Rosen AR; Steenland NK; Hanfelt J; Factor SA; Lah JJ; Levey AI -
PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain.
J Neuropathol Exp Neurol Volume: 66 Page(s): 955 - 964
10/01/2007 Authors: Anderson LR; Betarbet R; Gearing M; Gulcher J; Hicks AA; Stefnsson K; Lah JJ; Levey AI -
Influence of sleep disordered breathing on cognitive functioning among elderly with cognitive compromise
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY Volume: 22 Page(s): 817 - 817
09/01/2007 Authors: Yamout KZ; Bliwise DL; Goldstein FC; Wood-Siverio C; Lah JJ; Levey A -
Daytime sleepiness and functional impairment in Alzheimer disease.
Am J Geriatr Psychiatry Volume: 15 Page(s): 620 - 626
07/01/2007 Authors: Lee JH; Bliwise DL; Ansari FP; Goldstein FC; Cellar JS; Lah JJ; Levey AI -
Clinical and neuropathologic findings in a case of posterior cortical atrophy (PCA)
Volume: 66 Page(s): 422 - 422
05/01/2007 Authors: Gearing M; Brat DJ; Hunter SB; Cooper DS; Tehrani M; Lah JJ -
Clinical and neuropathologic findings in a case of posterior cortical atrophy (PCA)
Volume: 21 Page(s): A22 - A22
04/01/2007 Authors: Gearing M; Brat DJ; Hunter SB; Cooper DS; Tehrani M; Lah JJ -
Plaque amyloid per se plays no detectable role in timing of onset or initial severity of cognitive dysfunction in a mouse model of Alzheimer's
Volume: 68 Page(s): A188 - A189
03/20/2007 Authors: Gandy S; Lah J; Walker L; Kufahamu T; Pedrini S; Gieringer T; Levy E; Levey A; Abel T; Ehrlich M -
The role of LR11/SORL1 in Alzheimer's disease pathogenesis
Volume: 62 Page(s): S7 - S7
01/01/2007 Authors: Lah JJ; Offe K; Dodson SE; Sager KL; Khoogar L; Levey AI -
Changes in expression and distribution of LR11/Sorla distinguish between sporadic and genetic forms of Alzheimer's disease
Volume: 60 Page(s): 642 - 642
11/01/2006 Authors: Lah JJ; Dodson SE; Khoogar L; Mufson EJ; Levey AI -
LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease.
J Neuropathol Exp Neurol Volume: 65 Page(s): 866 - 872
09/01/2006 Authors: Dodson SE; Gearing M; Lippa CF; Montine TJ; Levey AI; Lah JJ -
Mild cognitive impairment: an opportunity to identify patients at high risk for progression to Alzheimer's disease.
Clin Ther Volume: 28 Page(s): 991 - 1001
07/01/2006 Authors: Levey A; Lah J; Goldstein F; Steenland K; Bliwise D -
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates.
Mol Neurodegener Volume: 1 Page(s): 3
06/12/2006 Authors: Nyborg AC; Ladd TB; Zwizinski CW; Lah JJ; Golde TE -
The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments.
J Neurosci Volume: 26 Page(s): 1596 - 1603
02/01/2006 Authors: Offe K; Dodson SE; Shoemaker JT; Fritz JJ; Gearing M; Levey AI; Lah JJ -
Merger of laser capture microdissection and mass spectrometry: a window into the amyloid plaque proteome.
Methods Enzymol Volume: 412 Page(s): 77 - 93
01/01/2006 Authors: Gozal YM; Cheng D; Duong DM; Lah JJ; Levey AI; Peng J -
LR11 regulates intracellular amyloid precursor protein traffic and amyloid accumulation in Alzheimer's disease
Volume: 58
12/01/2005 Authors: Lah JJ; Dodson SE; Offe K; Shoemaker JT; Levey AI -
Severe frontotemporal glial pathology and mild hippocampal degeneration associated with the P301L MAPT mutation: Study of a previously unreported family.
Volume: 64 Page(s): 434 - 434
05/01/2005 Authors: Spina S; Murrell JR; Gearing M; Levey A; Mirra S; Yamaguchi K; Ghetti B; Lah J -
Concomitant Alzheimer's disease and frontotemporal dementia-motor neuron disease subtype: A common neuropathologic phenomenon.
Volume: 64 Page(s): 433 - 433
05/01/2005 Authors: Gearing M; Lah JJ; Levey AI -
Hypertension and cognitive performance in African Americans with Alzheimer disease.
Neurology Volume: 64 Page(s): 899 - 901
03/08/2005 Authors: Goldstein FC; Ashley AV; Freedman LJ; Penix L; Lah JJ; Hanfelt J; Levey AI -
Feasibility of ambulatory overnight oximetry in consecutive patients in a dementia clinic.
J Am Geriatr Soc Volume: 53 Page(s): 545 - 546
03/01/2005 Authors: Bliwise DL; Lee J-H; Wood-Siverio C; Cellar JS; Lah JJ; Levey AI -
Common pattern of deficit in a multinational MCI cohort identified by objective computerized cognitive assessment
INTERNATIONAL PSYCHOGERIATRICS Volume: 17 Page(s): 252 - 253
01/01/2005 Authors: Dwolatzky T; Doniger G; Simon E; Goldstein F; Levey A; Lah J -
Daytime sleepiness associated with cognitive and functional impairments in Alzheimer's disease (AD)
Volume: 28 Page(s): A347 - A347
01/01/2005 Authors: Lee JH; Bliwise DL; Ansari FP; Goldstein FG; Cellar JS; Lah JJ; Levey AI -
Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection.
J Biol Chem Volume: 279 Page(s): 37061 - 37068
08/27/2004 Authors: Liao L; Cheng D; Wang J; Duong DM; Losik TG; Gearing M; Rees HD; Lah JJ; Levey AI; Peng J -
Loss of apolipoprotein E receptor LR11 in Alzheimer disease.
Arch Neurol Volume: 61 Page(s): 1200 - 1205
08/01/2004 Authors: Scherzer CR; Offe K; Gearing M; Rees HD; Fang G; Heilman CJ; Schaller C; Bujo H; Levey AI; Lah JJ -
Examining the role of the APOE receptor LR11 in the etiopathology of Alzheimer's disease
Volume: 25 Page(s): S441 - S441
07/01/2004 Authors: Dodson SE; Offe K; Carter SC; Shoemaker JT; Fan GF; Lah JJ; Levey AI -
Activity-dependent calcium entry in synaptosomes regulates app metabolism and A-beta production
Volume: 25 Page(s): S78 - S78
07/01/2004 Authors: Cook DG; Lab JJ; Wang J; Zhu P; Yang YX; Duerson KC -
Intermittent hypoxic insults occurring during a period of critical brain development reduce the expression of insoluble beta amyloid within the hippocampus
Volume: 25 Page(s): S166 - S166
07/01/2004 Authors: Jones KA; Carter S; Shoemaker JT; Solomon IG; Lah J; Levey A; Decker MJ -
Quantification of LR11 expression in mild cognitive impairment, a human model for early Alzheimer's disease
Volume: 25 Page(s): S439 - S439
07/01/2004 Authors: Sager KL; Lah JJ; Levey AI; Rees HD; Mufson EJ; Bennett DA; Wuu J; Leurgans S -
The "Mini-Cog" as a screen for dementia: Validation in an African American population
Volume: 25 Page(s): S131 - S132
07/01/2004 Authors: Ashley AV; Flacker J; Goldstein FC; Freedman LJ; Lah JJ; Levey AI -
Effect of targeted domain deletions on LR11-mediated regulation of extracellular A beta levels
Volume: 25 Page(s): S440 - S440
07/01/2004 Authors: Offe K; Williams TJ; Fang GF; Lah JJ; Levey AI -
Functional abilities in patients with mild cognitive impairment versus Alzheimer's disease and normal controls
Volume: 25 Page(s): S100 - S100
07/01/2004 Authors: Goldstein FC; Ashley AV; Freedman LJ; Cellar J; Harrison J; Lah JJ; Levey AI -
Reduced expression of the multifunctional apolipoprotein E receptor LR11 plays an important role in Alzheimer's disease pathogenesis.
Volume: 63 Page(s): 553 - 553
05/01/2004 Authors: Gearing M; Lah JJ; Sager KL; Offer K; Dodson SE; Carter SC; Bennett DA; Mufson EJ; Levey AI -
Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein.
J Biol Chem Volume: 278 Page(s): 36032 - 36040
09/19/2003 Authors: Hill K; Li Y; Bennett M; McKay M; Zhu X; Shern J; Torre E; Lah JJ; Levey AI; Kahn RA -
Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation.
J Biol Chem Volume: 278 Page(s): 17141 - 17149
05/09/2003 Authors: Huse JT; Byant D; Yang Y; Pijak DS; D'Souza I; Lah JJ; Lee VM-Y; Doms RW; Cook DG -
Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor.
J Neurosci Volume: 22 Page(s): 9776 - 9784
11/15/2002 Authors: Volpicelli LA; Lah JJ; Fang G; Goldenring JR; Levey AI -
BACE activity is regulated by an internal loop region whose sequence resembles the beta-secretase cleavage site of the amyloid precursor protein
NEUROBIOLOGY OF AGING Volume: 23 Page(s): S182 - S183
07/01/2002 Authors: McGraw W; Lah J; Levey A -
Effects of manipulating endosomal traffic on amyloid precursor protein metabolism and amyloid beta peptide secretion
NEUROLOGY Volume: 58 Page(s): A362 - A362
04/09/2002 Authors: Lah JJ; Levey AI -
Notch signaling inhibits PC12 cell neurite outgrowth via RBP-J-dependent and -independent mechanisms.
Dev Neurosci Volume: 24 Page(s): 79 - 88
01/01/2002 Authors: Levy OA; Lah JJ; Levey AI -
Rab5-dependent trafficking of the m4 muscarinic acetylcholine receptor to the plasma membrane, early endosomes, and multivesicular bodies.
J Biol Chem Volume: 276 Page(s): 47590 - 47598
12/14/2001 Authors: Volpicelli LA; Lah JJ; Levey AI -
Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein.
J Biol Chem Volume: 276 Page(s): 43343 - 43350
11/16/2001 Authors: Kim SH; Leem JY; Lah JJ; Slunt HH; Levey AI; Thinakaran G; Sisodia SS -
M1 and M4 subtypes of muscarinic receptors traffic through distinct endosomal compartments in PC12 cells
LIFE SCIENCES Volume: 68 Page(s): 2623 - 2623
04/27/2001 Authors: Volpicelli LA; Lah JJ; Levey AI -
The regulation of presenilin-1 by nerve growth factor.
J Neurochem Volume: 76 Page(s): 679 - 689
02/01/2001 Authors: Counts SE; Lah JJ; Levey AI -
Large-scale gene expression in Alzheimer's disease lymphoblasts
ANNALS OF NEUROLOGY Volume: 48 Page(s): 429 - 429
09/01/2000 Authors: Scherzer CR; Lah J; Bennett-Desmelik JA; Fang G; Counts S; Greenamyre JT; Levey AI -
Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments.
Mol Cell Neurosci Volume: 16 Page(s): 111 - 126
08/01/2000 Authors: Lah JJ; Levey AI -
Subcellular localization of presenilins: association with a unique membrane pool in cultured cells.
Neurobiol Dis Volume: 7 Page(s): 99 - 117
04/01/2000 Authors: Kim SH; Lah JJ; Thinakaran G; Levey A; Sisodia SS -
Localization and characterization of speech arrest during transcranial magnetic stimulation.
Clin Neurophysiol Volume: 110 Page(s): 1073 - 1079
06/01/1999 Authors: Epstein CM; Meador KJ; Loring DW; Wright RJ; Weissman JD; Sheppard S; Lah JJ; Puhalovich F; Gaitan L; Davey KR -
Muscarinic activation of MAPK in PC12 cells
LIFE SCIENCES Volume: 64 Page(s): 566 - 566
01/08/1999 Authors: Berkeley JL; Lah JJ; Levey AI -
Differential effects of transforming growth factor-beta(s) and glial cell line-derived neurotrophic factor on gene expression of presenilin-1 in human post-mitotic neurons and astrocytes.
Neuroscience Volume: 93 Page(s): 1041 - 1049
01/01/1999 Authors: Ren RF; Lah JJ; Diehlmann A; Kim ES; Hawver DB; Levey AI; Beyreuther K; Flanders KC -
Regulation of presenilin-1 during neuronotypic differentiation of PC12 cells
BRAIN PATHOLOGY Volume: 8 Page(s): 579 - 579
07/01/1998 Authors: Counts SE; Lah JJ; Levey AI -
Presenilin-1 protein expression in familial and sporadic Alzheimer's disease.
Ann Neurol Volume: 41 Page(s): 742 - 753
06/01/1997 Authors: Levey AI; Heilman CJ; Lah JJ; Nash NR; Rees HD; Wakai M; Mirra SS; Rye DB; Nochlin D; Bird TD -
Light and electron microscopic localization of presenilin-1 in primate brain.
J Neurosci Volume: 17 Page(s): 1971 - 1980
03/15/1997 Authors: Lah JJ; Heilman CJ; Nash NR; Rees HD; Yi H; Counts SE; Levey AI -
Optimum stimulus parameters for lateralized suppression of speech with magnetic brain stimulation.
Neurology Volume: 47 Page(s): 1590 - 1593
12/01/1996 Authors: Epstein CM; Lah JJ; Meador K; Weissman JD; Gaitan LE; Dihenia B -
Synaptophysin has a selective distribution in early endosomes of PC12 cells.
J Neurocytol Volume: 22 Page(s): 92 - 101
02/01/1993 Authors: Lah JJ; Burry RW -
Neuronotypic differentiation results in reduced levels and altered distribution of synaptophysin in PC12 cells.
J Neurochem Volume: 60 Page(s): 503 - 512
02/01/1993 Authors: Lah JJ; Burry RW -
GAP-43 distribution is correlated with development of growth cones and presynaptic terminals.
J Neurocytol Volume: 21 Page(s): 413 - 425
06/01/1992 Authors: Burry RW; Lah JJ; Hayes DM -
Redistribution of GAP-43 during growth cone development in vitro; immunocytochemical studies.
J Neurocytol Volume: 20 Page(s): 133 - 144
02/01/1991 Authors: Burry RW; Lah JJ; Hayes DM -
A neutral pH silver development method for the visualization of 1-nanometer gold particles in pre-embedding electron microscopic immunocytochemistry.
J Histochem Cytochem Volume: 38 Page(s): 503 - 508
04/01/1990 Authors: Lah JJ; Hayes DM; Burry RW