Publications

• Editorial: Cell death programs in the pathogenesis of heart disease.
  Front Physiol Volume: 16 Page(s): 1581282
  01/01/2025 Authors: Kwong JQ; Correll RN; Liu Q
• Analyzing Mitochondrial Calcium Influx in Isolated Mitochondria.
  Methods Mol Biol Volume: 2861 Page(s): 155 - 164
  01/01/2025 Authors: Ghazal N; Kwong JQ
• The mitochondrial citrate carrier SLC25A1 regulates metabolic reprogramming and morphogenesis in the developing heart.
  Commun Biol Volume: 7 Page(s): 1422
  10/31/2024 Authors: Ohanele C; Peoples JN; Karlstaedt A; Geiger JT; Gayle AD; Ghazal N; Sohani F; Brown ME; Davis ME; Porter GA
• Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function.
  Commun Biol Volume: 7 Page(s): 1342
  10/17/2024 Authors: Matsunaga Y; Qadota H; Ghazal N; Lesanpezeshki L; Dorendorf T; Moody JC; Ahier A; Matheny CJ; Vanapalli SA; Zuryn S
• Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart.
  bioRxiv
  05/13/2024 Authors: Ohanele C; Peoples JN; Karlstaedt A; Geiger JT; Gayle AD; Ghazal N; Sohani F; Brown ME; Davis ME; Porter GA
• Sex differences in the involvement of skeletal and cardiac muscles in myopathic Ano5-/- mice.
  Am J Physiol Cell Physiol Volume: 322 Page(s): C283 - C295
  02/01/2022 Authors: Foltz S; Wu F; Ghazal N; Kwong JQ; Hartzell HC; Choo HJ
• Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome.
  Am J Physiol Cell Physiol Volume: 321 Page(s): C519 - C534
  09/01/2021 Authors: Peoples JN; Ghazal N; Duong DM; Hardin KR; Manning JR; Seyfried NT; Faundez V; Kwong JQ
• Mitochondrial functional resilience after TFAM ablation in the adult heart.
  Am J Physiol Cell Physiol Volume: 320 Page(s): C929 - C942
  06/01/2021 Authors: Ghazal N; Peoples JN; Mohiuddin TA; Kwong JQ
• Heterogeneous Expression of Nuclear Encoded Mitochondrial Genes Distinguishes Inhibitory and Excitatory Neurons.
  eNeuro Volume: 8
  01/01/2021 Authors: Wynne ME; Lane AR; Singleton KS; Zlatic SA; Gokhale A; Werner E; Duong D; Kwong JQ; Crocker AJ; Faundez V
• MCUb Induction Protects the Heart From Postischemic Remodeling.
  Circ Res Volume: 127 Page(s): 379 - 390
  07/17/2020 Authors: Huo J; Lu S; Kwong JQ; Bround MJ; Grimes KM; Sargent MA; Brown ME; Davis ME; Bers DM; Molkentin JD
• Mitochondrial dysfunction and oxidative stress in heart disease.
  Exp Mol Med Volume: 51 Page(s): 1 - 13
  12/19/2019 Authors: Peoples JN; Saraf A; Ghazal N; Pham TT; Kwong JQ
• Exploring MCUb Function in the Heart and Its Role in Ischemia Reperfusion Injury
  Volume: 125
  08/02/2019 Authors: Huo J; Grimes K; Sargent M; York A; Kwong J; Molkentin J
• Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior.
  J Neurosci Volume: 39 Page(s): 3561 - 3581
  05/01/2019 Authors: Gokhale A; Hartwig C; Freeman AAH; Bassell JL; Zlatic SA; Sapp Savas C; Vadlamudi T; Abudulai F; Pham TT; Crocker A
• Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve.
  J Mol Cell Cardiol Volume: 127 Page(s): 223 - 231
  02/01/2019 Authors: Altamimi TR; Karwi QG; Uddin GM; Fukushima A; Kwong JQ; Molkentin JD; Lopaschuk GD
• Mitochondrial protein acylation is a post-translational signature of energy dysfunction.
  Volume: 29
  12/15/2018 Authors: Ghazal N; Kwong JQ
• The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle.
  JCI Insight Volume: 3
  11/15/2018 Authors: Kwong JQ; Huo J; Bround MJ; Boyer JG; Schwanekamp JA; Ghazal N; Maxwell JT; Jang YC; Khuchua Z; Shi K
• Analyses of Mitochondrial Calcium Influx in Isolated Mitochondria and Cultured Cells.
  J Vis Exp
  04/27/2018 Authors: Maxwell JT; Tsai C-H; Mohiuddin TA; Kwong JQ
• The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis.
  J Biol Chem Volume: 293 Page(s): 1887 - 1896
  02/09/2018 Authors: Boulet A; Vest KE; Maynard MK; Gammon MG; Russell AC; Mathews AT; Cole SE; Zhu X; Phillips CB; Kwong JQ
• The mitochondrial calcium uniporter in the heart: energetics and beyond.
  J Physiol Volume: 595 Page(s): 3743 - 3751
  06/15/2017 Authors: Kwong JQ
• MUTATIONAL AND BIOCHEMICAL ANALYSIS OF THE DUAL KINASE REGION OF UNC-89 (OBSCURIN).
  Volume: 28
  01/01/2017 Authors: Matsunaga Y; Qadota H; Moody JC; Kwong JQ; Benian GM
• Inhibition of Mitochondrial Calcium Uptake in the Heart Does Not Compromise Cardiac Energetics or Function Due to a Preferential Increase in Fatty Acid Oxidation During Increased Cardiac Work
  Volume: 134
  11/11/2016 Authors: Altamimi TR; Kwong J; Fukushima A; Molkentin JD; Lopaschuk GD
• Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes.
  Cardiovasc Res Volume: 112 Page(s): 491 - 501
  10/01/2016 Authors: Seidlmayer LK; Kuhn J; Berbner A; Arias-Loza P-A; Williams T; Kaspar M; Czolbe M; Kwong JQ; Molkentin JD; Heinze KG
• Thrombospondin expression in myofibers stabilizes muscle membranes.
  Elife Volume: 5
  09/26/2016 Authors: Vanhoutte D; Schips TG; Kwong JQ; Davis J; Tjondrokoesoemo A; Brody MJ; Sargent MA; Kanisicak O; Yi H; Gao QQ
• Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings.
  Circ Res Volume: 118 Page(s): 834 - 841
  03/04/2016 Authors: Lu X; Kwong JQ; Molkentin JD; Bers DM
• MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response.
  Nat Commun Volume: 6 Page(s): 10084
  12/16/2015 Authors: Davis J; Salomonis N; Ghearing N; Lin S-CJ; Kwong JQ; Mohan A; Swanson MS; Molkentin JD
• The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart.
  Cell Rep Volume: 12 Page(s): 15 - 22
  07/07/2015 Authors: Kwong JQ; Lu X; Correll RN; Schwanekamp JA; Vagnozzi RJ; Sargent MA; York AJ; Zhang J; Bers DM; Molkentin JD
• Physiological and pathological roles of the mitochondrial permeability transition pore in the heart.
  Cell Metab Volume: 21 Page(s): 206 - 214
  02/03/2015 Authors: Kwong JQ; Molkentin JD
• P38 MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism.
  Hum Mol Genet Volume: 23 Page(s): 5452 - 5463
  10/15/2014 Authors: Wissing ER; Boyer JG; Kwong JQ; Sargent MA; Karch J; McNally EM; Otsu K; Molkentin JD
• Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy.
  Cell Death Differ Volume: 21 Page(s): 1209 - 1217
  08/01/2014 Authors: Kwong JQ; Davis J; Baines CP; Sargent MA; Karch J; Wang X; Huang T; Molkentin JD
• Enhanced Ca influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy.
  Hum Mol Genet Volume: 23 Page(s): 3706 - 3715
  07/15/2014 Authors: Goonasekera SA; Davis J; Kwong JQ; Accornero F; Wei-LaPierre L; Sargent MA; Dirksen RT; Molkentin JD
• Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice.
  Elife Volume: 2 Page(s): e00772
  08/27/2013 Authors: Karch J; Kwong JQ; Burr AR; Sargent MA; Elrod JW; Peixoto PM; Martinez-Caballero S; Osinska H; Cheng EH-Y; Robbins J
• Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle.
  PLoS One Volume: 8 Page(s): e82053
  01/01/2013 Authors: Davis J; Kwong JQ; Kitsis RN; Molkentin JD
• The mitochondrial respiratory chain is a modulator of apoptosis.
  J Cell Biol Volume: 179 Page(s): 1163 - 1177
  12/17/2007 Authors: Kwong JQ; Henning MS; Starkov AA; Manfredi G
• The role of mitochondria in inherited neurodegenerative diseases.
  J Neurochem Volume: 97 Page(s): 1659 - 1675
  06/01/2006 Authors: Kwong JQ; Beal MF; Manfredi G
• Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis.
  Cancer Res Volume: 65 Page(s): 1655 - 1663
  03/01/2005 Authors: Shidara Y; Yamagata K; Kanamori T; Nakano K; Kwong JQ; Manfredi G; Oda H; Ohta S
• BCL-2 improves oxidative phosphorylation and modulates adenine nucleotide translocation in mitochondria of cells harboring mutant mtDNA.
  J Biol Chem Volume: 278 Page(s): 5639 - 5645
  02/21/2003 Authors: Manfredi G; Kwong JQ; Oca-Cossio JA; Woischnik M; Gajewski CD; Martushova K; D'Aurelio M; Friedlich AL; Moraes CT
• Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.
  Nat Genet Volume: 30 Page(s): 394 - 399
  04/01/2002 Authors: Manfredi G; Fu J; Ojaimi J; Sadlock JE; Kwong JQ; Guy J; Schon EA
• In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I.
  J Biol Chem Volume: 276 Page(s): 46925 - 46932
  12/14/2001 Authors: D'Aurelio M; Pallotti F; Barrientos A; Gajewski CD; Kwong JQ; Bruno C; Beal MF; Manfredi G
• Bcl-2 Suppresses Oxidative Phosphorylation Defects Caused by Mitochondrial DNA Mutations.
  ScientificWorldJournal Volume: 1 Page(s): 39
  01/01/2001 Authors: Manfredi G; Kwong JQ; Oca-Cossio JA; Aurelio MD; Gajewsky CD; Beal FM; Moraes CT