Jacob Kohlmeier
- Department of Microbiology and Immunology
Associate Professor
- (404) 727-7023
- jkohlmeier@emory.edu
-
Emory University School of Medicine
Microbiology and Immunology
1510 Clifton Rd., Room 3133 RRC
Overview
Dr. Jacob Kohlmeier earned his B.S. in Genetics and Ph.D. in Microbiology at the University of Kansas in Lawrence, KS. In the laboratory of Dr. Stephen Benedict, he investigated the role of adhesion molecules on human nave CD4 T cell function. Jake continued his training as a postdoctoral associate at the Trudeau Institute in Saranac Lake, NY in the laboratory of Dr. David Woodland. There he investigated the generation and recall of cellular immunity to influenza and parainfluenza viruses. Following several years as a research faculty member at Trudeau, Jake accepted a position as an Assistant Professor in the Department of Microbiology and Immunology at Emory University School of Medicine, where he continues to investigate immunity to respiratory pathogens.
Research
The mucosal surfaces of the respiratory, intestinal, and genital tracts are primary portals of entry for a wide range of pathogens. My laboratory studies the generation, maintenance, and recall of cellular immunity in the lung to better understand how pulmonary immune defenses can be harnessed to protect against respiratory pathogens.
The control of influenza and parainfluenza virus infections is mediated in part by T lymphocytes through the production of antiviral cytokines and the lysis of infected host cells within the lung tissue and lung airways. Following resolution of a primary infection, virus-specific memory T cells are established in secondary lymphoid organs and in peripheral tissues such as the lung tissue and lung airways. At the site of pathogen entry in the lung these cells can serve as sentinels to alert the immune system should a similar pathogen be reencountered, can help to orchestrate the appropriate secondary immune response, and can limit early pathogen replication.
Using a variety of molecular and genetic approaches to manipulate both the host and the pathogen, we are investigating how lung-resident lymphocytes are programmed to preferentially reside in the different compartments of the lung. We are also investigating the mechanisms these cells use to promote protective immunity, both directly through killing infected cells and indirectly through their interactions with other cells of the innate and adaptive immune system. Our goal is to translate these findings to develop vaccine strategies that promote the most efficacious immune memory for defense against respiratory pathogens. Finally, we are utilizing our knowledge of lung airway immunology during infection to address the dysregulation of immune function in the airways of patients with lung disease, with a particular focus on cystic fibrosis.
Research Topics
Cellular And Molecular Immunology
Development Of Novel Vaccines
Viral Pathogenesis
Academic Appointment
- Assistant Professor, Department of Microbiology and Immunology, Emory University School of Medicine
Education
Degrees
- PhD from University of Kansas
- B.G.S. from University of Kansas
- BS from University of Kansas
Research
Publications
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An aberrant immune-epithelial progenitor niche drives viral lung sequelae.
Nature Volume: 634 Page(s): 961 - 969
10/01/2024 Authors: Narasimhan H; Cheon IS; Qian W; Hu SS; Parimon T; Li C; Goplen N; Wu Y; Wei X; Son YM -
CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment.
Sci Adv Volume: 10 Page(s): eadp2636
08/23/2024 Authors: Kar M; Johnson KEE; Vanderheiden A; Elrod EJ; Floyd K; Geerling E; Stone ET; Salinas E; Banakis S; Wang W -
Eosinophils protect against SARS-CoV-2 following a vaccine breakthrough infection.
bioRxiv
08/10/2024 Authors: Moore KM; Foster SL; Kar M; Floyd KA; Elrod EJ; Williams ME; Velden JV; Ellis M; Malik A; Wali B -
Prevention of respiratory virus transmission by resident memory CD8+ T cells.
Nature Volume: 626 Page(s): 392 - 400
02/01/2024 Authors: Uddbck I; Michalets SE; Saha A; Mattingly C; Kost KN; Williams ME; Lawrence LA; Hicks SL; Lowen AC; Ahmed H -
The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling.
Mucosal Immunol Volume: 17 Page(s): 41 - 53
02/01/2024 Authors: Elliott Williams M; Hardnett FP; Sheth AN; Wein AN; Li Z-RT; Radzio-Basu J; Dinh C; Haddad LB; Collins EMB; Ofotokun I -
CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment.
bioRxiv
01/24/2024 Authors: Kar M; Johnson KEE; Vanderheiden A; Elrod EJ; Floyd K; Geerling E; Stone ET; Salinas E; Banakis S; Wang W -
Both Humoral and Cellular Immunity Limit the Ability of Live Attenuated Influenza Vaccines to Promote T Cell Responses.
J Immunol Volume: 212 Page(s): 107 - 116
01/01/2024 Authors: Lobby JL; Danzy S; Holmes KE; Lowen AC; Kohlmeier JE -
Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice.
EMBO Rep Volume: 24 Page(s): e56660
04/05/2023 Authors: Kenney AD; Zani A; Kawahara J; Eddy AC; Wang X-L; Mahesh KC; Lu M; Thomas J; Kohlmeier JE; Suthar MS -
Vaccine induced memory CD8+ T cells efficiently prevent viral transmission from the respiratory tract.
Front Immunol Volume: 14 Page(s): 1322536
01/01/2023 Authors: Zhou J; Uddback I; Kohlmeier JE; Christensen JP; Thomsen AR -
Persistent Antigen Harbored by Alveolar Macrophages Enhances the Maintenance of Lung-Resident Memory CD8+ T Cells.
J Immunol Volume: 209 Page(s): 1778 - 1787
11/01/2022 Authors: Lobby JL; Uddbck I; Scharer CD; Mi T; Boss JM; Thomsen AR; Christensen JP; Kohlmeier JE