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Profile

Jacob Kohlmeier

  • Department of Microbiology and Immunology
    Associate Professor
  • (404) 727-7023
  • jkohlmeier@emory.edu
  • Emory University School of Medicine
    Microbiology and Immunology
    1510 Clifton Rd., Room 3133 RRC
Head shot of Jacob Kohlmeier

Overview

Dr. Jacob Kohlmeier earned his B.S. in Genetics and Ph.D. in Microbiology at the University of Kansas in Lawrence, KS. In the laboratory of Dr. Stephen Benedict, he investigated the role of adhesion molecules on human nave CD4 T cell function. Jake continued his training as a postdoctoral associate at the Trudeau Institute in Saranac Lake, NY in the laboratory of Dr. David Woodland. There he investigated the generation and recall of cellular immunity to influenza and parainfluenza viruses. Following several years as a research faculty member at Trudeau, Jake accepted a position as an Assistant Professor in the Department of Microbiology and Immunology at Emory University School of Medicine, where he continues to investigate immunity to respiratory pathogens.
Research
The mucosal surfaces of the respiratory, intestinal, and genital tracts are primary portals of entry for a wide range of pathogens. My laboratory studies the generation, maintenance, and recall of cellular immunity in the lung to better understand how pulmonary immune defenses can be harnessed to protect against respiratory pathogens.

The control of influenza and parainfluenza virus infections is mediated in part by T lymphocytes through the production of antiviral cytokines and the lysis of infected host cells within the lung tissue and lung airways. Following resolution of a primary infection, virus-specific memory T cells are established in secondary lymphoid organs and in peripheral tissues such as the lung tissue and lung airways. At the site of pathogen entry in the lung these cells can serve as sentinels to alert the immune system should a similar pathogen be reencountered, can help to orchestrate the appropriate secondary immune response, and can limit early pathogen replication.

Using a variety of molecular and genetic approaches to manipulate both the host and the pathogen, we are investigating how lung-resident lymphocytes are programmed to preferentially reside in the different compartments of the lung. We are also investigating the mechanisms these cells use to promote protective immunity, both directly through killing infected cells and indirectly through their interactions with other cells of the innate and adaptive immune system. Our goal is to translate these findings to develop vaccine strategies that promote the most efficacious immune memory for defense against respiratory pathogens. Finally, we are utilizing our knowledge of lung airway immunology during infection to address the dysregulation of immune function in the airways of patients with lung disease, with a particular focus on cystic fibrosis.

Research Topics
Cellular And Molecular Immunology
Development Of Novel Vaccines
Viral Pathogenesis

Academic Appointment

  • Assistant Professor, Department of Microbiology and Immunology, Emory University School of Medicine

Education

Degrees

  • PhD from University of Kansas
  • B.G.S. from University of Kansas
  • BS from University of Kansas

Research

Publications

  • An aberrant immune-epithelial progenitor niche drives viral lung sequelae.
    Nature Volume: 634 Page(s): 961 - 969
    10/01/2024 Authors: Narasimhan H; Cheon IS; Qian W; Hu SS; Parimon T; Li C; Goplen N; Wu Y; Wei X; Son YM
  • CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment.
    Sci Adv Volume: 10 Page(s): eadp2636
    08/23/2024 Authors: Kar M; Johnson KEE; Vanderheiden A; Elrod EJ; Floyd K; Geerling E; Stone ET; Salinas E; Banakis S; Wang W
  • Eosinophils protect against SARS-CoV-2 following a vaccine breakthrough infection.
    bioRxiv
    08/10/2024 Authors: Moore KM; Foster SL; Kar M; Floyd KA; Elrod EJ; Williams ME; Velden JV; Ellis M; Malik A; Wali B
  • Prevention of respiratory virus transmission by resident memory CD8+ T cells.
    Nature Volume: 626 Page(s): 392 - 400
    02/01/2024 Authors: Uddbck I; Michalets SE; Saha A; Mattingly C; Kost KN; Williams ME; Lawrence LA; Hicks SL; Lowen AC; Ahmed H
  • The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling.
    Mucosal Immunol Volume: 17 Page(s): 41 - 53
    02/01/2024 Authors: Elliott Williams M; Hardnett FP; Sheth AN; Wein AN; Li Z-RT; Radzio-Basu J; Dinh C; Haddad LB; Collins EMB; Ofotokun I
  • CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment.
    bioRxiv
    01/24/2024 Authors: Kar M; Johnson KEE; Vanderheiden A; Elrod EJ; Floyd K; Geerling E; Stone ET; Salinas E; Banakis S; Wang W
  • Both Humoral and Cellular Immunity Limit the Ability of Live Attenuated Influenza Vaccines to Promote T Cell Responses.
    J Immunol Volume: 212 Page(s): 107 - 116
    01/01/2024 Authors: Lobby JL; Danzy S; Holmes KE; Lowen AC; Kohlmeier JE
  • Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice.
    EMBO Rep Volume: 24 Page(s): e56660
    04/05/2023 Authors: Kenney AD; Zani A; Kawahara J; Eddy AC; Wang X-L; Mahesh KC; Lu M; Thomas J; Kohlmeier JE; Suthar MS
  • Vaccine induced memory CD8+ T cells efficiently prevent viral transmission from the respiratory tract.
    Front Immunol Volume: 14 Page(s): 1322536
    01/01/2023 Authors: Zhou J; Uddback I; Kohlmeier JE; Christensen JP; Thomsen AR
  • Persistent Antigen Harbored by Alveolar Macrophages Enhances the Maintenance of Lung-Resident Memory CD8+ T Cells.
    J Immunol Volume: 209 Page(s): 1778 - 1787
    11/01/2022 Authors: Lobby JL; Uddbck I; Scharer CD; Mi T; Boss JM; Thomsen AR; Christensen JP; Kohlmeier JE
  • Erratum for Vanderheiden et al., "CCR2 Signaling Restricts SARS-CoV-2 Infection".
    mBio Volume: 13 Page(s): e0025922
    06/28/2022 Authors: Vanderheiden A; Thomas J; Soung AL; Davis-Gardner ME; Floyd K; Jin F; Cowan DA; Pellegrini K; Creanga A; Pegu A
  • Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis.
    Proc Natl Acad Sci U S A Volume: 119 Page(s): e2202012119
    05/24/2022 Authors: Eltobgy MM; Zani A; Kenney AD; Estfanous S; Kim E; Badr A; Carafice C; Daily K; Whitham O; Pietrzak M
  • Sex differences in the relationships between body composition, fat distribution, and mitochondrial energy metabolism: a pilot study.
    Nutr Metab (Lond) Volume: 19 Page(s): 37
    05/21/2022 Authors: Bellissimo MP; Fleischer CC; Reiter DA; Goss AM; Zhou L; Smith MR; Kohlmeier J; Tirouvanziam R; Tran PH; Hao L
  • A Novel H-2d Epitope for Influenza A Polymerase Acidic Protein.
    Viruses Volume: 14
    03/14/2022 Authors: Uddbck I; Kohlmeier JE; Thomsen AR; Christensen JP
  • CCR2 Signaling Restricts SARS-CoV-2 Infection.
    mBio Volume: 12 Page(s): e0274921
    12/21/2021 Authors: Vanderheiden A; Thomas J; Soung AL; Davis-Gardner ME; Floyd K; Jin F; Cowan DA; Pellegrini K; Shi P-Y; Grakoui A
  • Resident Memory CD8+T cells in the respiratory tract limits transmission of respiratory viruses
    Volume: 94
    12/01/2021 Authors: Uddback I; Mattingly C; Li Z; Thomas J; Kost K; Thomsen AR; Scharer C; Christensen JP; Kohlmeier J
  • CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection.
    bioRxiv
    05/04/2021 Authors: Vanderheiden A; Thomas J; Soung AL; Davis-Gardner ME; Floyd K; Jin F; Cowan DA; Pellegrini K; Creanga A; Pegu A
  • Identifying mechanisms that enhance the longevity of tissue-resident memory CD8+T cells in the lung
    Volume: 206
    05/01/2021 Authors: Lobby JL; Uddback IEM; Scharer CD; Mi T; Boss JM; Thomsen AR; Christensen JP; Kohlmeier JE
  • Resident Memory CD8+T cells in the respiratory tract prevent transmission of respiratory viruses
    Volume: 206
    05/01/2021 Authors: Uddback IEM; Mattingly C; Thomas J; Kost KN; Li Z-RT; Thomsen AR; Scharer CD; Christensen JP; Kohlmeier JE
  • Long-term maintenance of lung resident memory T cells is mediated by persistent antigen.
    Mucosal Immunol Volume: 14 Page(s): 92 - 99
    01/01/2021 Authors: Uddbck I; Cartwright EK; Schller AS; Wein AN; Hayward SL; Lobby J; Takamura S; Thomsen AR; Kohlmeier JE; Christensen JP
  • Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures.
    J Virol Volume: 94
    09/15/2020 Authors: Vanderheiden A; Ralfs P; Chirkova T; Upadhyay AA; Zimmerman MG; Bedoya S; Aoued H; Tharp GM; Pellegrini KL; Manfredi C
  • Identifying mechanisms that enhance the longevity of tissue-resident memory T cells in the lung
    Volume: 204
    05/01/2020 Authors: Lobby JL; Uddback I; Cartwright E; Hayward SL; Takamura S; Thomsen AR; Christensen J; Kohlmeier JE
  • Migratory memory CD4 T cells surveilling the lower reproductive tract direct rapid clearance of Chlamydia muridarum following vaginal challenge
    Volume: 204
    05/01/2020 Authors: Kohlmeier A; Li T; Lobby J; Kost K; Dunbar P; Lowen A; Zheng H; Kohlmeier JE
  • Lung-resident memory CD8(+) T cells prevent transmission of respiratory viruses
    Volume: 204
    05/01/2020 Authors: Uddback IEM; Laccette KH; Li Z-RT; Kohlmeier JE
  • Harnessing Cross-Reactive CD8+ TRM Cells for Long-Standing Protection Against Influenza A Virus.
    Viral Immunol Volume: 33 Page(s): 201 - 207
    04/01/2020 Authors: Uddbck I; Kohlmeier JE; Thomsen AR; Christensen JP
  • The Human Lung Glycome Reveals Novel Glycan Ligands for Influenza A Virus.
    Sci Rep Volume: 10 Page(s): 5320
    03/24/2020 Authors: Jia N; Byrd-Leotis L; Matsumoto Y; Gao C; Wein AN; Lobby JL; Kohlmeier JE; Steinhauer DA; Cummings RD
  • Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells.
    Nat Immunol Volume: 21 Page(s): 309 - 320
    03/01/2020 Authors: Hayward SL; Scharer CD; Cartwright EK; Takamura S; Li Z-RT; Boss JM; Kohlmeier JE
  • Pulmonary monocytes interact with effector T cells in the lung tissue to drive TRM differentiation following viral infection.
    Mucosal Immunol Volume: 13 Page(s): 161 - 171
    01/01/2020 Authors: Dunbar PR; Cartwright EK; Wein AN; Tsukamoto T; Tiger Li Z-R; Kumar N; Uddbck IE; Hayward SL; Ueha S; Takamura S
  • CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways.
    J Exp Med Volume: 216 Page(s): 2748 - 2762
    12/02/2019 Authors: Wein AN; McMaster SR; Takamura S; Dunbar PR; Cartwright EK; Hayward SL; McManus DT; Shimaoka T; Ueha S; Tsukui T
  • PD-1hi CD8+ resident memory T cells balance immunity and fibrotic sequelae.
    Sci Immunol Volume: 4
    06/14/2019 Authors: Wang Z; Wang S; Goplen NP; Li C; Cheon IS; Dai Q; Huang S; Shan J; Ma C; Ye Z
  • Chronic immune barrier dysregulation among women with a history of violence victimization.
    JCI Insight Volume: 4
    05/16/2019 Authors: Swaims-Kohlmeier A; Haddad LB; Li Z-RT; Brookmeyer KA; Baker JM; Widom CS; Lamousin JC; Chi K-H; Chen CY; Kersh EN
  • Chronic immune barrier dysregulation among women with a history of violence victimization
    Volume: 202
    05/01/2019 Authors: Kohlmeier A; Haddad LB; Li TZ-R; Brookmeyer KA; Baker JM; Chen CY; Kersh EN; Herbst-Kralovetz MM; Hogben M; Ofotokun I
  • CD8+T Cells require IL-27R for optimal generation of an effector response during influenza infection
    Volume: 202
    05/01/2019 Authors: Dunbar P; Li Z-RT; Lobby J; Hayward SL; Lawrence L; Kohlmeier JE
  • Persistent antigen can maintain lung resident memory CD8 T cells long-term
    Volume: 202
    05/01/2019 Authors: Uddback IEM; Cartwright E; Scholler AS; Hayward SL; Lobby J; Takamura S; Thomsen AR; Kohlmeier JE; Christsensen JP
  • Unrelated respiratory infections compromise established cellular immunity by promoting apoptosis of pre-existing lung-resident memory CD8 T cells
    Volume: 202
    05/01/2019 Authors: Hayward SL; Li ZRT; Lobby JL; Eggert JOP; Kohlmeier JE
  • Quantifying the selection on influenza A virus imposed by CD8 T cells
    Volume: 202
    05/01/2019 Authors: Li Z-RT; Zarnitsyna VI; Lowen AC; Kohlmeier JE; Antia R
  • Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?
    J Virol Volume: 93
    03/15/2019 Authors: Li Z-RT; Zarnitsyna VI; Lowen AC; Weissman D; Koelle K; Kohlmeier JE; Antia R
  • Establishment and Maintenance of Conventional and Circulation-Driven Lung-Resident Memory CD8+ T Cells Following Respiratory Virus Infections.
    Front Immunol Volume: 10 Page(s): 733
    01/01/2019 Authors: Takamura S; Kohlmeier JE
  • A Regional Mucosal Immunology Approach to Measuring HIV Susceptibility at Barrier Tissue Sites
    Volume: 34 Page(s): 307 - 307
    10/01/2018 Authors: Swaims-Kohlmeier A; Dobard C; Kohlmeier J; Garcia-Lerma JG
  • IL-36 Protects against Severe Influenza Infection by Promoting Lung Alveolar Macrophage Survival and Limiting Viral Replication.
    J Immunol Volume: 201 Page(s): 573 - 582
    07/15/2018 Authors: Wein AN; Dunbar PR; McMaster SR; Li Z-RT; Denning TL; Kohlmeier JE
  • Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma.
    Mucosal Immunol Volume: 11 Page(s): 1071 - 1078
    07/01/2018 Authors: McMaster SR; Wein AN; Dunbar PR; Hayward SL; Cartwright EK; Denning TL; Kohlmeier JE
  • B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation.
    Nat Commun Volume: 9 Page(s): 1900
    05/15/2018 Authors: Barwick BG; Scharer CD; Martinez RJ; Price MJ; Wein AN; Haines RR; Bally APR; Kohlmeier JE; Boss JM
  • Cellular stress mediated by the local microenvironment regulates the homeostatic loss of tissue-resident memory CD8 T cells in different compartments of the lung
    Volume: 200
    05/01/2018 Authors: Hayward SL; Scharer CD; Takamura S; Kumar G; Boss JM; Kohlmeier JE
  • IL-36 signaling controls the induced regulatory T cell-Th9 cell balance via NFB activation and STAT transcription factors.
    Mucosal Immunol Volume: 10 Page(s): 1455 - 1467
    11/01/2017 Authors: Harusato A; Abo H; Ngo VL; Yi SW; Mitsutake K; Osuka S; Kohlmeier JE; Li JD; Gewirtz AT; Nusrat A
  • Differential localization of distinct CD4 T cell subsets in the female genital tract during the menstrual cycle is regulated by CCR5
    JOURNAL OF IMMUNOLOGY Volume: 198
    05/01/2017 Authors: Kohlmeier A; McMaster S; Li Z-R; Radzio-Basu J; Haddad LB; Sheth AN; Cong M-E; Dinh C; Martin A; Hayward SL
  • O-012 IL-36 Signaling Controls the Induced Regulatory T Cell-TH9 Cell Balance and Gut Inflammation.
    Inflamm Bowel Dis Volume: 23 Suppl 1 Page(s): S4 - S5
    02/01/2017 Authors: Harusato A; Abo H; Ngo V; Yi S; Osuka S; Kohlmeier J; Li J-D; Gewirtz A; Nusrat A; Denning T
  • IL-36 Signaling Controls the Induced Regulatory T Cell-TH9 Cell Balance and Gut Inflammation
    Volume: 23 Page(s): S4 - S5
    02/01/2017 Authors: Harusato A; Abo H; Vu N; Yi S; Osuka S; Kohlmeier J; Li J-D; Gewirtz A; Nusrat A; Denning T
  • Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
    J Exp Med Volume: 213 Page(s): 3057 - 3073
    12/12/2016 Authors: Takamura S; Yagi H; Hakata Y; Motozono C; McMaster SR; Masumoto T; Fujisawa M; Chikaishi T; Komeda J; Itoh J
  • A Distinct Lung-Interstitium-Resident Memory CD8(+) T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection.
    Cell Rep Volume: 16 Page(s): 1800 - 1809
    08/16/2016 Authors: Gilchuk P; Hill TM; Guy C; McMaster SR; Boyd KL; Rabacal WA; Lu P; Shyr Y; Kohlmeier JE; Sebzda E
  • The role of IL-36 in the immune response to influenza infection
    Volume: 46 Page(s): 80 - 80
    08/01/2016 Authors: Wein A; Dunbar P; McMaster S; Hayward S; Denning T; Kohlmeier J
  • Progesterone Levels Associate with a Novel Population of CCR5+CD38+ CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential.
    J Immunol Volume: 197 Page(s): 368 - 376
    07/01/2016 Authors: Swaims-Kohlmeier A; Haaland RE; Haddad LB; Sheth AN; Evans-Strickfaden T; Lupo LD; Cordes S; Aguirre AJ; Lupoli KA; Chen C-Y
  • Distinct migratory phenotypes of luminal CD4 T cell subsets in the female genital tract
    Volume: 196
    05/01/2016 Authors: Kohlmeier A; Haddad L; Haaland R; Lupo D; Ofotokun I; Hart C; Kohlmeier JE
  • Tissue-resident monocytes promote the establishment of lung-resident CD8 T cell memory following influenza infection
    Volume: 196
    05/01/2016 Authors: Dunbar P; Wein AN; McMaster SR; Hayward SL; Kohlmeier JE
  • Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity.
    J Immunol Volume: 196 Page(s): 2838 - 2846
    03/15/2016 Authors: Krummey SM; Martinez RJ; Andargachew R; Liu D; Wagener M; Kohlmeier JE; Evavold BD; Larsen CP; Ford ML
  • Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage.
    J Immunol Volume: 196 Page(s): 34 - 38
    01/01/2016 Authors: Medina-Contreras O; Harusato A; Nishio H; Flannigan KL; Ngo V; Leoni G; Neumann P-A; Geem D; Lili LN; Ramadas RA
  • Mathematical Model Reveals the Role of Memory CD8 T Cell Populations in Recall Responses to Influenza.
    Front Immunol Volume: 7 Page(s): 165
    01/01/2016 Authors: Zarnitsyna VI; Handel A; McMaster SR; Hayward SL; Kohlmeier JE; Antia R
  • Enhanced immune responses by skin vaccination with influenza subunit vaccine in young hosts.
    Vaccine Volume: 33 Page(s): 4675 - 4682
    09/08/2015 Authors: Koutsonanos DG; Esser ES; McMaster SR; Kalluri P; Lee J-W; Prausnitz MR; Skountzou I; Denning TL; Kohlmeier JE; Compans RW
  • Airway-Resident Memory CD8 T Cells Provide Antigen-Specific Protection against Respiratory Virus Challenge through Rapid IFN- Production.
    J Immunol Volume: 195 Page(s): 203 - 209
    07/01/2015 Authors: McMaster SR; Wilson JJ; Wang H; Kohlmeier JE
  • Recirculating HIV-target T lymphocytes at the mucosal surface of the female genital tract are associated with progesterone increases during the menstrual cycle
    JOURNAL OF IMMUNOLOGY Volume: 194
    05/01/2015 Authors: Swaims A; Haaland R; Evans-Strickfaden T; Haadad L; Sheth A; Lupo L; Cordes S; Aguirre A; Lupoli K; Chen C-Y
  • Memory T cells generated by prior exposure to influenza cross react with the novel H7N9 influenza virus and confer protective heterosubtypic immunity.
    PLoS One Volume: 10 Page(s): e0115725
    01/01/2015 Authors: McMaster SR; Gabbard JD; Koutsonanos DG; Compans RW; Tripp RA; Tompkins SM; Kohlmeier JE
  • CD4 T cells specific for a latency-associated -herpesvirus epitope are polyfunctional and cytotoxic.
    J Immunol Volume: 193 Page(s): 5827 - 5834
    12/15/2014 Authors: Freeman ML; Burkum CE; Cookenham T; Roberts AD; Lanzer KG; Huston GE; Jensen MK; Sidney J; Peters B; Kohlmeier JE
  • Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza.
    Viral Immunol Volume: 27 Page(s): 484 - 496
    12/01/2014 Authors: Sell S; Guest I; McKinstry KK; Strutt TM; Kohlmeier JE; Brincks E; Tighe M; Blackman MA; Woodland DL; Dutton RW
  • Low Affinity CD8(+) CD45RB(high) TNF-Producing T-CM Are Potently Alloreactive Against High Affinity Antigen in a Model of T Cell Receptor Cross-Reactive Heterologous Immunity
    Volume: 98 Page(s): 33 - 33
    07/15/2014 Authors: Krummey S; Martinez R; Liu D; Wagener M; Kohlmeier J; Evavold B; Larsen C; Ford M
  • Low Affinity CD8(+) CD45RB(high) TNF-Producing T-CM Are Potently Alloreactive Against High Affinity Antigen in a Model of T Cell Receptor Cross-Reactive Heterologous Immunity.
    Volume: 14 Page(s): 33 - 33
    06/01/2014 Authors: Krummey S; Martinez R; Liu D; Wagener M; Kohlmeier J; Evavold B; Larsen C; Ford M
  • Both local antigen and inflammation are required to establish resident memory CD8 T cell populations in the lung parenchyma and airways
    JOURNAL OF IMMUNOLOGY Volume: 192
    05/01/2014 Authors: McMaster S; Wilson J; Wang H; Kohlmeier J
  • Correction: Early dysregulation of the memory CD8+ T cell repertoire leads to compromised immune responses to secondary viral infection in the aged.
    Immun Ageing Volume: 10 Page(s): 40
    10/11/2013 Authors: Connor LM; Kohlmeier JE; Ryan L; Roberts AD; Cookenham T; Quinn A; Blackman MA; Woodland DL
  • Intra-epithelial T lymphocytes from the cervical-vaginal mucosa of healthy women contain a majority population of CD4+cells and express high levels of the HIV-1 co-receptor CCR5.
    Volume: 190
    05/01/2013 Authors: Swaims A; Haaland R; Lupo D; Evans-Strickfaden T; Kohlmeier J; Haddad L; Hart C
  • The role of CXCR6 in lung airway memory CD8 T cell recruitment and maintenance
    Volume: 190
    05/01/2013 Authors: McMaster S; Wilson J; Wang H; Kohlmeier J
  • Respiratory airway memory cells pre-arm the immune system against viral reinfection
    Volume: 190
    05/01/2013 Authors: Wilson J; McMaster S; Wang H; Kohlmeier J
  • Natural Killer cells in defense against parainfluenza virus
    Volume: 190
    05/01/2013 Authors: Hendricks D; Kohlmeier J; Lanier L
  • Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection.
    J Immunol Volume: 190 Page(s): 3438 - 3446
    04/01/2013 Authors: Brincks EL; Roberts AD; Cookenham T; Sell S; Kohlmeier JE; Blackman MA; Woodland DL
  • Early dysregulation of the memory CD8+ T cell repertoire leads to compromised immune responses to secondary viral infection in the aged.
    Immun Ageing Volume: 9 Page(s): 28
    12/18/2012 Authors: Connor LM; Kohlmeier JE; Ryan L; Roberts AD; Cookenham T; Blackman MA; Woodland DL
  • Immunity to the conserved influenza nucleoprotein reduces susceptibility to secondary bacterial infections.
    J Immunol Volume: 189 Page(s): 4921 - 4929
    11/15/2012 Authors: Haynes L; Szaba FM; Eaton SM; Kummer LW; Lanthier PA; Petell AH; Duso DK; Luo D; Lin J-S; Lefebvre JS
  • Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response.
    Proc Natl Acad Sci U S A Volume: 109 Page(s): 18535 - 18540
    11/06/2012 Authors: Perona-Wright G; Kohlmeier JE; Bassity E; Freitas TC; Mohrs K; Cookenham T; Situ H; Pearce EJ; Woodland DL; Mohrs M
  • Memory Treg cells regulate the immune response to influenza virus infection
    Volume: 188
    05/01/2012 Authors: Brincks E; Roberts A; Cookenham T; Sell S; Blackman M; Kohlmeier J; Woodland D
  • Live attenuated influenza vaccine (LAIV) impacts innate and adaptive immune responses.
    Vaccine Volume: 29 Page(s): 7849 - 7856
    10/13/2011 Authors: Lanthier PA; Huston GE; Moquin A; Eaton SM; Szaba FM; Kummer LW; Tighe MP; Kohlmeier JE; Blair PJ; Broderick M
  • Inflammatory chemokine receptors regulate CD8(+) T cell contraction and memory generation following infection.
    J Exp Med Volume: 208 Page(s): 1621 - 1634
    08/01/2011 Authors: Kohlmeier JE; Reiley WW; Perona-Wright G; Freeman ML; Yager EJ; Connor LM; Brincks EL; Cookenham T; Roberts AD; Burkum CE
  • Inflammatory chemokine receptors regulate CD8 T cell contraction and memory generation following infection
    JOURNAL OF IMMUNOLOGY Volume: 186
    04/01/2011 Authors: Kohlmeier J; Reiley W; Perona-Wright G; Freeman M; Eric Y; Connor L; Brincks E; Cookenham T; Roberts A; Burkum C
  • A persistent loss of cytokine responsiveness defines CD8+memory T cell function
    JOURNAL OF IMMUNOLOGY Volume: 186
    04/01/2011 Authors: Perona-Wright G; Kohlmeier J; Mohrs K; Cookenham T; Woodland D; Mohrs M
  • Virus-specific T cell clonal expansions can limit recall responses to secondary respiratory virus infections
    JOURNAL OF IMMUNOLOGY Volume: 186
    04/01/2011 Authors: Connor L; Ryan L; Kohlmeier J; Cookenham T; Roberts A; Quinn A; Woodland D
  • Choice of resident costimulatory molecule can influence cell fate in human nave CD4+ T cell differentiation.
    Cell Immunol Volume: 271 Page(s): 418 - 427
    01/01/2011 Authors: Williams KM; Dotson AL; Otto AR; Kohlmeier JE; Benedict SH
  • Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection.
    J Immunol Volume: 185 Page(s): 3456 - 3462
    09/15/2010 Authors: Kohlmeier JE; Connor LM; Roberts AD; Cookenham T; Martin K; Woodland DL
  • Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge.
    Immunity Volume: 33 Page(s): 96 - 105
    07/23/2010 Authors: Kohlmeier JE; Cookenham T; Roberts AD; Miller SC; Woodland DL
  • The route of priming influences the ability of respiratory virus-specific memory CD8+ T cells to be activated by residual antigen.
    J Exp Med Volume: 207 Page(s): 1153 - 1160
    06/07/2010 Authors: Takamura S; Roberts AD; Jelley-Gibbs DM; Wittmer ST; Kohlmeier JE; Woodland DL
  • A call to arms: interferons prepare bone marrow cells to battle peripheral infections.
    Cell Host Microbe Volume: 7 Page(s): 336 - 337
    05/20/2010 Authors: Kohlmeier JE; Woodland DL
  • IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool.
    J Immunol Volume: 184 Page(s): 35 - 44
    01/01/2010 Authors: Sandau MM; Kohlmeier JE; Woodland DL; Jameson SC
  • CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection.
    J Immunol Volume: 183 Page(s): 4378 - 4384
    10/01/2009 Authors: Kohlmeier JE; Cookenham T; Miller SC; Roberts AD; Christensen JP; Thomsen AR; Woodland DL
  • Type I interferon-dependent regulation of granzyme B protein expression by memory CD8+T cells during the early stages of a respiratory virus challenge
    JOURNAL OF IMMUNOLOGY Volume: 182
    04/01/2009 Authors: Kohlmeier JE; Miller SC; Cookenham T; Roberts AD; Woodland DL
  • Brief costimulation through ICAM-1 of human na ve CD4+T cells induces differentiation to a memory phenotype days later
    JOURNAL OF IMMUNOLOGY Volume: 182
    04/01/2009 Authors: Dotson AL; Kohlmeier JE; Cool KM; Benedict SH
  • Migration, maintenance and recall of memory T cells in peripheral tissues.
    Nat Rev Immunol Volume: 9 Page(s): 153 - 161
    03/01/2009 Authors: Woodland DL; Kohlmeier JE
  • Immunity to respiratory viruses.
    Annu Rev Immunol Volume: 27 Page(s): 61 - 82
    01/01/2009 Authors: Kohlmeier JE; Woodland DL
  • The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections.
    Immunity Volume: 29 Page(s): 101 - 113
    07/18/2008 Authors: Kohlmeier JE; Miller SC; Smith J; Lu B; Gerard C; Cookenham T; Roberts AD; Woodland DL
  • Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection.
    J Immunol Volume: 180 Page(s): 693 - 697
    01/15/2008 Authors: Mayer KD; Mohrs K; Reiley W; Wittmer S; Kohlmeier JE; Pearl JE; Cooper AM; Johnson LL; Woodland DL; Mohrs M
  • Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections.
    J Immunol Volume: 179 Page(s): 3535 - 3542
    09/15/2007 Authors: Ely KH; Ahmed M; Kohlmeier JE; Roberts AD; Wittmer ST; Blackman MA; Woodland DL
  • Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells.
    J Exp Med Volume: 204 Page(s): 1625 - 1636
    07/09/2007 Authors: Hikono H; Kohlmeier JE; Takamura S; Wittmer ST; Roberts AD; Woodland DL
  • Aging and CD8+ T cell immunity to respiratory virus infections.
    Exp Gerontol Volume: 42 Page(s): 427 - 431
    05/01/2007 Authors: Ely KH; Roberts AD; Kohlmeier JE; Blackman MA; Woodland DL
  • Cutting edge: Antigen is not required for the activation and maintenance of virus-specific memory CD8+ T cells in the lung airways.
    J Immunol Volume: 178 Page(s): 4721 - 4725
    04/15/2007 Authors: Kohlmeier JE; Miller SC; Woodland DL
  • Costimulation through ICAM-1 induces differentiation of naive human CD4+T cells from aging individuals
    JOURNAL OF IMMUNOLOGY Volume: 178
    04/01/2007 Authors: Dotson AL; Kohlmeier JE; Cool KM; Benedict SH
  • Costimulation Through ICAM-1 Induces Differentiation of Human Naive CD4+T Cells to Regulato T Cells
    JOURNAL OF IMMUNOLOGY Volume: 178
    04/01/2007 Authors: Cool KM; Dotson AL; Otto AR; Kohlmeier JE; Benedict SH
  • CD8 T cell memory to respiratory virus infections
    Volume: 120 Page(s): 14 - 14
    03/01/2007 Authors: Woodland DL; Kohlmeier JE; Hikono H; Ely KH; Miller S; Roberts AD
  • Costimulation of naive human CD4 T cells through intercellular adhesion molecule-1 promotes differentiation to a memory phenotype that is not strictly the result of multiple rounds of cell division.
    Immunology Volume: 118 Page(s): 549 - 558
    08/01/2006 Authors: Kohlmeier JE; Chan MA; Benedict SH
  • Memory T cell recruitment to the lung airways.
    Curr Opin Immunol Volume: 18 Page(s): 357 - 362
    06/01/2006 Authors: Kohlmeier JE; Woodland DL
  • T-cell memory and recall responses to respiratory virus infections.
    Immunol Rev Volume: 211 Page(s): 119 - 132
    06/01/2006 Authors: Hikono H; Kohlmeier JE; Ely KH; Scott I; Roberts AD; Blackman MA; Woodland DL
  • Central memory CD8+T cells mediate optimal recall responses to respiratory virus infections
    Volume: 176 Page(s): S117 - S117
    04/01/2006 Authors: Hikono H; Kohlmeier J; Wittmer S; Roberts AD; Woodland DL
  • Inflammatory mediators and immune function are altered in home parenteral nutrition patients.
    Nutrition Volume: 22 Page(s): 97 - 103
    02/01/2006 Authors: Hise ME; Compher C; Harlan L; Kohlmeier JE; Benedict SH; Gajewski B; Brown JC
  • The suitability of yellow fever and Japanese encephalitis vaccines for immunization against West Nile virus.
    Vaccine Volume: 23 Page(s): 4785 - 4792
    09/15/2005 Authors: Yamshchikov G; Borisevich V; Kwok CW; Nistler R; Kohlmeier J; Seregin A; Chaporgina E; Benedict S; Yamshchikov V
  • Alternate costimulatory molecules in T cell activation: differential mechanisms for directing the immune response.
    Histol Histopathol Volume: 18 Page(s): 1195 - 1204
    10/01/2003 Authors: Kohlmeier JE; Benedict SH
  • T cell activation and differentiation of naive human CD4+T cells costimulated through ICAM-1 are distinct from those observed through CD28 or LFA-1
    Volume: 17 Page(s): C213 - C213
    04/14/2003 Authors: Kohlmeier JE; Benedict SH
  • The outcome of T-cell costimulation through intercellular adhesion molecule-1 differs from costimulation through leucocyte function-associated antigen-1.
    Immunology Volume: 108 Page(s): 152 - 157
    02/01/2003 Authors: Kohlmeier JE; Rumsey LM; Chan MA; Benedict SH
  • Stimulation through intercellular adhesion molecule-1 provides a second signal for T cell activation.
    J Immunol Volume: 168 Page(s): 5530 - 5537
    06/01/2002 Authors: Chirathaworn C; Kohlmeier JE; Tibbetts SA; Rumsey LM; Chan MA; Benedict SH
  • ICAM-1 stimulation modulates gene expression in T cells
    FASEB JOURNAL Volume: 14 Page(s): A1141 - A1141
    04/20/2000 Authors: Kohlmeier J; Wick BM; Rumsey LM; Chan MA; Benedict SH
  • Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506.
    Phytother Res Volume: 13 Page(s): 464 - 467
    09/01/1999 Authors: Chan MA; Kohlmeier JE; Branden M; Jung M; Benedict SH
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