Publications

• Antitumor Activity of Vebreltinib and Characterization of Clinicogenomic Features in Solid Tumors with MET Rearrangements.
  Cancer Discov Volume: 15 Page(s): 1129 - 1140
  06/03/2025 Authors: Nakazawa S; Pecci F; Odintsov I; Gazgalis D; Gottlieb FH; Ricciuti B; Zullo L; Alessi JV; Di Federico A; Aldea M
• Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer.
  Sci Adv Volume: 11 Page(s): eadu0847
  04/25/2025 Authors: Gui F; Jiang B; Jiang J; He Z; Tsujino T; Takai T; Arai S; Pana C; Kllermann J; Bradshaw GA
• Activating Mutations in the MET Kinase Domain Co-Occur With Other Driver Oncogenes and Mediate Resistance to Targeted Therapy in NSCLC.
  J Thorac Oncol
  04/02/2025 Authors: Nakazawa S; Pecci F; Ricciuti B; Gottlieb FH; Facchinetti F; Harada G; Chen MF; Repetto M; Giacomini F; Jiang J
• Biochemical analysis of EGFR exon20 insertion variants insASV and insSVD and their inhibitor sensitivity.
  Proc Natl Acad Sci U S A Volume: 121 Page(s): e2417144121
  11/05/2024 Authors: Zhao H; Beyett TS; Jiang J; Rana JK; Schaeffner IK; Santana J; Jnne PA; Eck MJ
• Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7).
  Eur J Med Chem Volume: 276 Page(s): 116613
  10/05/2024 Authors: Ji W; Du G; Jiang J; Lu W; Mills CE; Yuan L; Jiang F; He Z; Bradshaw GA; Chung M
• Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors.
  Cancer Discov Volume: 14 Page(s): 1440 - 1456
  08/02/2024 Authors: Pecci F; Nakazawa S; Ricciuti B; Harada G; Lee JK; Alessi JV; Barrichello A; Vaz VR; Lamberti G; Di Federico A
• Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality.
  ACS Cent Sci Volume: 10 Page(s): 1156 - 1166
  06/26/2024 Authors: Li Z; Jiang J; Ficarro SB; Beyett TS; To C; Tavares I; Zhu Y; Li J; Eck MJ; Jnne PA
• ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases.
  J Med Chem Volume: 67 Page(s): 2837 - 2848
  02/22/2024 Authors: Li Z; Lu W; Beyett TS; Ficarro SB; Jiang J; Tse J; Kim AY-J; Marto JA; Che J; Jnne PA
• TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk.
  Cell Rep Volume: 43 Page(s): 113662
  01/23/2024 Authors: Hou Y; Li Y; Xiang J-F; Tilahun K; Jiang J; Corces VG; Yao B
• Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2-dependent ISR in C9ORF72 FTD/ALS.
  Elife Volume: 12
  04/19/2023 Authors: Parameswaran J; Zhang N; Braems E; Tilahun K; Pant DC; Yin K; Asress S; Heeren K; Banerjee A; Davis E
• Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease.
  Proc Natl Acad Sci U S A Volume: 119 Page(s): e2123487119
  12/06/2022 Authors: Jambeau M; Meyer KD; Hruska-Plochan M; Tabet R; Lee C-Z; Ray-Soni A; Aguilar C; Savage K; Mishra N; Cavegn N
• Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling.
  Elife Volume: 11
  10/27/2022 Authors: Fan M; Lu W; Che J; Kwiatkowski NP; Gao Y; Seo H-S; Ficarro SB; Gokhale PC; Liu Y; Geffken EA
• Exploring the target scope of KEAP1 E3 ligase-based PROTACs.
  Cell Chem Biol Volume: 29 Page(s): 1470 - 1481.e31
  10/20/2022 Authors: Du G; Jiang J; Henning NJ; Safaee N; Koide E; Nowak RP; Donovan KA; Yoon H; You I; Yue H
• Asparagine bioavailability regulates the translation of MYC oncogene.
  Oncogene Volume: 41 Page(s): 4855 - 4865
  10/01/2022 Authors: Srivastava S; Jiang J; Misra J; Seim G; Staschke KA; Zhong M; Zhou L; Liu Y; Chen C; Dav U
• Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.
  Eur J Med Chem Volume: 238 Page(s): 114433
  08/05/2022 Authors: Li Z; Ishida R; Liu Y; Wang J; Li Y; Gao Y; Jiang J; Che J; Sheltzer JM; Robers MB
• ALS-linked KIF5A Exon27 mutant causes neuronal toxicity through gain-of-function.
  EMBO Rep Volume: 23 Page(s): e54234
  08/03/2022 Authors: Pant DC; Parameswaran J; Rao L; Loss I; Chilukuri G; Parlato R; Shi L; Glass JD; Bassell GJ; Koch P
• Integrin 5 Is Regulated by miR-218-5p in Endothelial Progenitor Cells.
  J Am Soc Nephrol Volume: 33 Page(s): 565 - 582
  03/01/2022 Authors: Liu J; Li Y; Lyu L; Xiao L; Memon AA; Yu X; Halim A; Patel S; Osman A; Yin W
• Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.
  Eur J Med Chem Volume: 221 Page(s): 113481
  10/05/2021 Authors: Jiang B; Jiang J; Kaltheuner IH; Iniguez AB; Anand K; Ferguson FM; Ficarro SB; Seong BKA; Greifenberg AK; Dust S
• Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2.
  Angew Chem Int Ed Engl Volume: 60 Page(s): 15905 - 15911
  07/12/2021 Authors: Du G; Jiang J; Wu Q; Henning NJ; Donovan KA; Yue H; Che J; Lu W; Fischer ES; Bardeesy N
• Discovery and resistance mechanism of a selective CDK12 degrader.
  Nat Chem Biol Volume: 17 Page(s): 675 - 683
  06/01/2021 Authors: Jiang B; Gao Y; Che J; Lu W; Kaltheuner IH; Dries R; Kalocsay M; Berberich MJ; Jiang J; You I
• Discovery of Covalent MKK4/7 Dual Inhibitor.
  Cell Chem Biol Volume: 27 Page(s): 1553 - 1560.e8
  12/17/2020 Authors: Jiang J; Jiang B; He Z; Ficarro SB; Che J; Marto JA; Gao Y; Zhang T; Gray NS
• RNA-mediated toxicity in C9orf72 ALS and FTD.
  Neurobiol Dis Volume: 145 Page(s): 105055
  11/01/2020 Authors: McEachin ZT; Parameswaran J; Raj N; Bassell GJ; Jiang J
• Development of CDK2 and CDK5 Dual Degrader TMX-2172.
  Angew Chem Int Ed Engl Volume: 59 Page(s): 13865 - 13870
  08/10/2020 Authors: Teng M; Jiang J; He Z; Kwiatkowski NP; Donovan KA; Mills CE; Victor C; Hatcher JM; Fischer ES; Sorger PK
• Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.
  Neuron Volume: 107 Page(s): 292 - 305.e6
  07/22/2020 Authors: McEachin ZT; Gendron TF; Raj N; Garca-Murias M; Banerjee A; Purcell RH; Ward PJ; Todd TW; Merritt-Garza ME; Jansen-West K
• Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72.
  Nat Neurosci Volume: 23 Page(s): 615 - 624
  05/01/2020 Authors: Zhu Q; Jiang J; Gendron TF; McAlonis-Downes M; Jiang L; Taylor A; Diaz Garcia S; Ghosh Dastidar S; Rodriguez MJ; King P
• Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.
  J Med Chem Volume: 63 Page(s): 1624 - 1641
  02/27/2020 Authors: Du G; Rao S; Gurbani D; Henning NJ; Jiang J; Che J; Yang A; Ficarro SB; Marto JA; Aguirre AJ
• Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion.
  J Biol Chem Volume: 294 Page(s): 18674 - 18684
  12/06/2019 Authors: Jiang J; Srivastava S; Seim G; Pavlova NN; King B; Zou L; Zhang C; Zhong M; Feng H; Kapur R
• Pathogenic Mechanisms and Therapy Development for C9orf72 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia.
  Neurotherapeutics Volume: 16 Page(s): 1115 - 1132
  10/01/2019 Authors: Jiang J; Ravits J
• Rare variants in MYH15 modify amyotrophic lateral sclerosis risk.
  Hum Mol Genet Volume: 28 Page(s): 2309 - 2318
  07/15/2019 Authors: Kim H; Lim J; Bao H; Jiao B; Canon SM; Epstein MP; Xu K; Jiang J; Parameswaran J; Li Y
• Antisense RNA foci and poly-GR dipeptide repeat proteins are unique in repeat-expanded C9orf72 ALS/FTD
  Volume: 77 Page(s): 511 - 511
  06/01/2018 Authors: Saberi S; Stauffer J; Jiang J; Garcia SD; Taylor A; Schulte D; Ohkubo T; Schloffman C; Maldonado M; Baughn M
• Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis.
  Acta Neuropathol Volume: 135 Page(s): 459 - 474
  03/01/2018 Authors: Saberi S; Stauffer JE; Jiang J; Garcia SD; Taylor AE; Schulte D; Ohkubo T; Schloffman CL; Maldonado M; Baughn M
• CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts.
  Nat Commun Volume: 9 Page(s): 152
  01/11/2018 Authors: Tabet R; Schaeffer L; Freyermuth F; Jambeau M; Workman M; Lee C-Z; Lin C-C; Jiang J; Jansen-West K; Abou-Hamdan H
• C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2 phosphorylation.
  Nat Commun Volume: 9 Page(s): 51
  01/04/2018 Authors: Cheng W; Wang S; Mestre AA; Fu C; Makarem A; Xian F; Hayes LR; Lopez-Gonzalez R; Drenner K; Jiang J
• Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72.
  Neuron Volume: 92 Page(s): 1160 - 1163
  12/21/2016 Authors: Jiang J; Cleveland DW
• Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers
  Volume: 138 Page(s): 339 - 340
  08/01/2016 Authors: Gendron T; van Blitterswijk M; Bieniek K; Daughrity L; Jiang J; Rush B; Pedraza O; Lucas J; Murray M; Desaro P
• Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs.
  Neuron Volume: 90 Page(s): 535 - 550
  05/04/2016 Authors: Jiang J; Zhu Q; Gendron TF; Saberi S; McAlonis-Downes M; Seelman A; Stauffer JE; Jafar-Nejad P; Drenner K; Schulte D
• C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.
  Nat Neurosci Volume: 19 Page(s): 668 - 677
  05/01/2016 Authors: Zhang Y-J; Gendron TF; Grima JC; Sasaguri H; Jansen-West K; Xu Y-F; Katzman RB; Gass J; Murray ME; Shinohara M
• Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72.
  Acta Neuropathol Volume: 130 Page(s): 863 - 876
  12/01/2015 Authors: van Blitterswijk M; Gendron TF; Baker MC; DeJesus-Hernandez M; Finch NA; Brown PH; Daughrity LM; Murray ME; Heckman MG; Jiang J
• Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers.
  Acta Neuropathol Volume: 130 Page(s): 559 - 573
  10/01/2015 Authors: Gendron TF; van Blitterswijk M; Bieniek KF; Daughrity LM; Jiang J; Rush BK; Pedraza O; Lucas JA; Murray ME; Desaro P
• A Mutation in Transmembrane Domain 7 (TM7) of Excitatory Amino Acid Transporters Disrupts the Substrate-dependent Gating of the Intrinsic Anion Conductance and Drives the Channel into a Constitutively Open State.
  J Biol Chem Volume: 290 Page(s): 22977 - 22990
  09/18/2015 Authors: Torres-Salazar D; Jiang J; Divito CB; Garcia-Olivares J; Amara SG
• Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.
  Proc Natl Acad Sci U S A Volume: 110 Page(s): E4530 - E4539
  11/19/2013 Authors: Lagier-Tourenne C; Baughn M; Rigo F; Sun S; Liu P; Li H-R; Jiang J; Watt AT; Chun S; Katz M
• Large collective motions regulate the functional properties of glutamate transporter trimers.
  Proc Natl Acad Sci U S A Volume: 108 Page(s): 15141 - 15146
  09/13/2011 Authors: Jiang J; Shrivastava IH; Watts SD; Bahar I; Amara SG
• New views of glutamate transporter structure and function: advances and challenges.
  Neuropharmacology Volume: 60 Page(s): 172 - 181
  01/01/2011 Authors: Jiang J; Amara SG
• Application of Gaussian Network Model to Elucidate Functional Modes of Motion in a Glutamate Transporter
  Volume: 98 Page(s): 632A - 632A
  01/01/2010 Authors: Shrivastava I; Jiang J; Amara SG; Bahar I
• Sulfhydryl Modification Of Cysteine Substitutions In The Second Hairpin Loop (HP2) Alters The Ion Permeation Properties Of The Glutamate Transporter, EAAT1
  Volume: 96 Page(s): 271A - 271A
  02/01/2009 Authors: Torres-Salazar D; Jiang J; Amara SG
• Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter.
  J Biol Chem Volume: 283 Page(s): 28680 - 28690
  10/17/2008 Authors: Shrivastava IH; Jiang J; Amara SG; Bahar I
• Hypoalgesia in mice lacking GABA transporter subtype 1.
  J Neurosci Res Volume: 86 Page(s): 465 - 470
  02/01/2008 Authors: Xu YF; Cai YQ; Cai GQ; Jiang J; Sheng ZJ; Wang ZG; Fei J
• Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype 1.
  Neuropsychopharmacology Volume: 32 Page(s): 1531 - 1539
  07/01/2007 Authors: Liu G-X; Cai G-Q; Cai Y-Q; Sheng Z-J; Jiang J; Mei Z; Wang Z-G; Guo L; Fei J
• Reduced aggression in mice lacking GABA transporter subtype 1.
  J Neurosci Res Volume: 85 Page(s): 649 - 655
  02/15/2007 Authors: Liu G-X; Liu S; Cai G-Q; Sheng Z-J; Cai Y-Q; Jiang J; Sun X; Ma S-K; Wang L; Wang Z-G
• [Ethanol affects the function of gamma-aminobutyric acid transporter I in mice brain].
  Shi Yan Sheng Wu Xue Bao Volume: 37 Page(s): 315 - 320
  08/01/2004 Authors: Jiang J; Hu JH; Wu M; Guo LH; Fei J
• Identification of glutamate transporters and receptors in mouse testis.
  Acta Pharmacol Sin Volume: 25 Page(s): 366 - 371
  03/01/2004 Authors: Hu J-H; Yang N; Ma Y-H; Jiang J; Zhang J-F; Fei J; Guo L-H
• Impaired reproduction in transgenic mice overexpressing Gamma-aminobutyric acid transporter I (GAT1).
  Cell Res Volume: 14 Page(s): 54 - 59
  02/01/2004 Authors: Hu JH; Zhang JF; Ma YH; Jiang J; Yang N; Li XB; Yu Chi ZG; Fei J; Guo LH
• Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1).
  Neuroreport Volume: 15 Page(s): 9 - 12
  01/19/2004 Authors: Hu J-H; Ma Y-H; Jiang J; Yang N; Duan S-H; Jiang Z-H; Mei Z-T; Fei J; Guo L-H
• Identification of glutamate receptors and transporters in mouse and human sperm.
  J Androl Volume: 25 Page(s): 140 - 146
  01/01/2004 Authors: Hu JH; Yang N; Ma YH; Jiang J; Zhang JF; Fei J; Guo LH
• Decrease of morphine-induced reward effects and withdrawal symptoms in mice overexpressing gamma-aminobutyric acid transporter I.
  J Neurosci Res Volume: 74 Page(s): 614 - 621
  11/15/2003 Authors: Hu J-H; Yang N; Ma Y-H; Zhou X-G; Zhang X-Y; Jiang J; Mei Z-T; Fei J; Guo L-H
• Enhancement of germ cell apoptosis induced by ethanol in transgenic mice overexpressing Fas Ligand.
  Cell Res Volume: 13 Page(s): 361 - 367
  10/01/2003 Authors: Hu JH; Jiang J; Ma YH; Yang N; Zhang MH; Wu M; Fei J; Guo LH
• Hyperalgesic effects of gamma-aminobutyric acid transporter I in mice.
  J Neurosci Res Volume: 73 Page(s): 565 - 572
  08/15/2003 Authors: Hu J-H; Yang N; Ma Y-H; Zhou X-G; Jiang J; Duan S-H; Mei Z-T; Fei J; Guo L-H