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Profile

Joshy Jacob PhD

  • Department of Microbiology and Immunology
    Professor
  • (404) 727-7919
  • jjacob3@emory.edu
  • Pubmed
  • Emory National Primate Center
    Emory University
    954 Gatewood Rd
Head shot of Joshy Jacob

Overview

Dr. Jacob is a Professor in the Emory School of Medicine Department of Microbiology and Immunology. He received his Ph.D. in immunology from the University of Maryland School of Medicine at Baltimore, and did his post-doctoral training at the Rockefeller University and the Massachusetts Institute of Technology.

Research
Though the existence of immunological memory, which enables the immune system to remember infections and respond accordingly, has been recognized for centuries, our understanding of the cellular and molecular basis of this type of memory remains limited. As a basic immunologist, Dr. Joshy Jacob seeks to understand how B cell memory is generated, regulated and maintained.

Dr. Jacob also studies the phenomenon known as original antigenic sin. Humans previously exposed to influenza virus, upon infection with a novel influenza strain, produce antibodies directed primarily against the older viral strains at the expense of responses to novel protective antigenic determinants thus exacerbating the severity of current infection. This blind spot of the immune system and the redirection of responses to the original antigen, but not to the current virus is well established but poorly understood. Since original antigenic sin drastically dampens immune responses to newer strains of influenza virus, Dr. Jacob seeks to understand the fundamental aspects of this phenomenon such that vaccines capable of overcoming original antigenic sin can be designed.

Research Topics
Cellular And Molecular Immunology
Development Of Novel Vaccines
Emerging Infectious Diseases

Academic Appointment

  • Associate Professor with Tenure, Microbiology and Immunology, Emory University School of Medicine
  • Affiliate Scientist, Emory National Primate Center

Education

Degrees

  • PhD from University of Maryland
  • BS from University of Texas-Pan American

Research

Focus

  • The research of my laboratory is focused upon studying (a) fundamental aspects of B cell memory and (b) original antigenic sin responses to influenza virus.

Publications

  • Molecular features of the serological IgG repertoire elicited by egg-based, cell-based, or recombinant haemagglutinin-based seasonal influenza vaccines: a comparative, prospective, observational cohort study.
    Lancet Microbe Volume: 6 Page(s): 100935
    02/01/2025 Authors: Park J; Bartzoka F; von Beck T; Li Z-N; Mishina M; Hebert LS; Kain J; Liu F; Sharma S; Cao W
  • Distinct Replication Kinetics, Cytopathogenicity, and Immune Gene Regulation in Human Microglia Cells Infected with Asian and African Lineages of Zika Virus.
    Microorganisms Volume: 12
    09/05/2024 Authors: Bird IM; Cavener V; Surendran Nair M; Nissly RH; Chothe SK; Jacob J; Kuchipudi SV
  • Analysis of rare genetic variants in All of Us cohort patients with common variable immunodeficiency.
    Front Genet Volume: 15 Page(s): 1409754
    01/01/2024 Authors: von Beck T; Patel M; Patel NC; Jacob J
  • A wild boar cathelicidin peptide derivative inhibits severe acute respiratory syndrome coronavirus-2 and its drifted variants.
    Sci Rep Volume: 13 Page(s): 14650
    09/05/2023 Authors: von Beck T; Navarrete K; Arce NA; Gao M; Dale GA; Davis-Gardner ME; Floyd K; Mena Hernandez L; Mullick N; Vanderheiden A
  • Atovaquone and Pibrentasvir Inhibit the SARS-CoV-2 Endoribonuclease and Restrict Infection In Vitro but Not In Vivo.
    Viruses Volume: 15
    08/30/2023 Authors: von Beck T; Mena Hernandez L; Zhou H; Floyd K; Suthar MS; Skolnick J; Jacob J
  • Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis.
    J Immunol Volume: 208 Page(s): 2141 - 2153
    05/01/2022 Authors: Dale GA; Wilkins DJ; Rowley J; Scharer CD; Tipton CM; Hom J; Boss JM; Corces V; Sanz I; Jacob J
  • A Novel Neuraminidase Virus-Like Particle Vaccine Offers Protection Against Heterologous H3N2 Influenza Virus Infection in the Porcine Model.
    Front Immunol Volume: 13 Page(s): 915364
    01/01/2022 Authors: Pliasas VC; Menne Z; Aida V; Yin J-H; Naskou MC; Neasham PJ; North JF; Wilson D; Horzmann KA; Jacob J
  • Prediction of severe adverse events, modes of action and drug treatments for COVID-19's complications.
    Sci Rep Volume: 11 Page(s): 20864
    10/21/2021 Authors: Astore C; Zhou H; Jacob J; Skolnick J
  • The amphibian peptide Yodha is virucidal for Zika and dengue viruses.
    Sci Rep Volume: 11 Page(s): 602
    01/12/2021 Authors: Lee SH; Kim EH; O'neal JT; Dale G; Holthausen DJ; Bowen JR; Quicke KM; Skountzou I; Gopal S; George S
  • Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.
    Elife Volume: 9
    06/09/2020 Authors: Kim EH; Woodruff MC; Grigoryan L; Maier B; Lee SH; Mandal P; Cortese M; Natrajan MS; Ravindran R; Ma H
  • Templated mutagenesis in B cell non-Ig genes
    Volume: 204
    05/01/2020 Authors: Navarrete K; Dale GA; Woodruff MC; Scharer CD; Boss JM; Sanz I; Jacob J
  • Early AID expression in developing B cells marks a population with a restricted IgH repertoire favoring D-proximal V-H gene usage
    Volume: 204
    05/01/2020 Authors: von Beck TA; Dale G; Jacob J
  • DISTINCTIVE FEATURES OF CARBAPENEM-RESISTANT ENTEROBACTERIACEAE RESISTANT ONLY TO ERTAPENEM, ATLANTA, GA, 2016-2018
    Volume: 68 Page(s): 691 - 691
    02/01/2020 Authors: Adelman M; Bower C; Blakney R; Howard-Anderson J; Ansari U; Lutgring J; Jacob J
  • Interchromosomal templated mutagenesis accounts for mutation clusters in B cell non-Ig genes
    Volume: 49 Page(s): 340 - 340
    10/01/2019 Authors: Navarrete K; Dale G; Wilkins D; Jacob J
  • A subset of somatic mutations in switched memory B cells are generated from interchromosomal templates
    Volume: 49 Page(s): 286 - 286
    10/01/2019 Authors: Dale G; Wilkins D; Rowley M; Corces V; Sanz I; Jacob J
  • Optimizing frog-derived antimicrobial peptides for use as antivirals
    Volume: 49 Page(s): 1861 - 1861
    10/01/2019 Authors: Shartouny J; Jacob J
  • Clustered Mutations at the Murine and Human IgH Locus Exhibit Significant Linkage Consistent with Templated Mutagenesis.
    J Immunol Volume: 203 Page(s): 1252 - 1264
    09/01/2019 Authors: Dale GA; Wilkins DJ; Bohannon CD; Dilernia D; Hunter E; Bedford T; Antia R; Sanz I; Jacob J
  • Mining the tree of life: Host defense peptides as antiviral therapeutics.
    Semin Cell Dev Biol Volume: 88 Page(s): 147 - 155
    04/01/2019 Authors: Shartouny JR; Jacob J
  • A Multi-Stage Plasmodium vivax Malaria Vaccine Candidate Able to Induce Long-Lived Antibody Responses Against Blood Stage Parasites and Robust Transmission-Blocking Activity.
    Front Cell Infect Microbiol Volume: 9 Page(s): 135
    01/01/2019 Authors: McCaffery JN; Fonseca JA; Singh B; Cabrera-Mora M; Bohannon C; Jacob J; Arvalo-Herrera M; Moreno A
  • A synthetic stroma-free germinal center niche for efficient generation of humoral immunity exvivo.
    Biomaterials Volume: 164 Page(s): 106 - 120
    05/01/2018 Authors: Roh K-H; Song HW; Pradhan P; Bai K; Bohannon CD; Dale G; Leleux J; Jacob J; Roy K
  • A HYBRID PLASMODIUM VIVAX BLOOD STAGE-TRANSMISSION BLOCKING VACCINE CANDIDATE ELICITS ROBUST CELLULAR IMMUNE RESPONSES AND LONG-LIVED FUNCTIONAL ANTIBODIES
    Volume: 95 Page(s): 313 - 313
    11/01/2017 Authors: Fonseca JA; Singh B; Bohannon C; Cabrera-Mora M; Jacob J; Arevalo-Herrera M; Moreno A
  • An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin-Bearing Influenza Viruses.
    Immunity Volume: 46 Page(s): 587 - 595
    04/18/2017 Authors: Holthausen DJ; Lee SH; Kumar VT; Bouvier NM; Krammer F; Ellebedy AH; Wrammert J; Lowen AC; George S; Pillai MR
  • Quantifying the shifting landscape of B cell immunodominance.
    Nat Immunol Volume: 18 Page(s): 367 - 368
    03/22/2017 Authors: Dale GA; Shartouny JR; Jacob J
  • Non-neutralizing antibodies induced by seasonal influenza vaccine prevent, not exacerbate A(H1N1)pdm09 disease.
    Sci Rep Volume: 6 Page(s): 37341
    11/16/2016 Authors: Kim JH; Reber AJ; Kumar A; Ramos P; Sica G; Music N; Guo Z; Mishina M; Stevens J; York IA
  • Tetanus vaccination with a dissolving microneedle patch confers protective immune responses in pregnancy.
    J Control Release Volume: 236 Page(s): 47 - 56
    08/28/2016 Authors: Esser ES; Romanyuk A; Vassilieva EV; Jacob J; Prausnitz MR; Compans RW; Skountzou I
  • Corrigendum: Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection.
    Nat Commun Volume: 7 Page(s): 12687
    08/16/2016 Authors: Bohannon C; Powers R; Satyabhama L; Cui A; Tipton C; Michaeli M; Skountzou I; Mittler RS; Kleinstein SH; Mehr R
  • Innate mediators of amphibian immunity provide protection against human influenza viruses
    Volume: 46 Page(s): 95 - 95
    08/01/2016 Authors: Holthausen D; George S; Jacob J
  • The role of gene conversion in the diversification of murine IgM plasma cells
    Volume: 46 Page(s): 63 - 64
    08/01/2016 Authors: Dale G; Bohannon C; Antia R; Jacob J
  • Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection.
    Nat Commun Volume: 7 Page(s): 11826
    06/07/2016 Authors: Bohannon C; Powers R; Satyabhama L; Cui A; Tipton C; Michaeli M; Skountzou I; Mittler RS; Kleinstein SH; Mehr R
  • Prior infection with influenza virus but not vaccination leaves a long-term immunological imprint that intensifies the protective efficacy of antigenically drifted vaccine strains.
    Vaccine Volume: 34 Page(s): 495 - 502
    01/20/2016 Authors: Kim JH; Liepkalns J; Reber AJ; Lu X; Music N; Jacob J; Sambhara S
  • Masking of antigenic epitopes by antibodies shapes the humoral immune response to influenza.
    Philos Trans R Soc Lond B Biol Sci Volume: 370
    09/05/2015 Authors: Zarnitsyna VI; Ellebedy AH; Davis C; Jacob J; Ahmed R; Antia R
  • Long-lived IgM plasma cells confer host protection against viral challenge
    Volume: 194
    05/01/2015 Authors: Bohannon C; Powers R; Satyabhama L; Cui A; Tipton C; Michaeli M; Mehr R; Mittler R; Kleinstein S; Sanz I
  • Host Defense Peptides from Asian Frogs as Potential Clinical Therapies.
    Antibiotics (Basel) Volume: 4 Page(s): 136 - 159
    03/30/2015 Authors: Kumar VTV; Holthausen D; Jacob J; George S
  • Influenza virus-specific neutralizing IgM antibodies persist for a lifetime.
    Clin Vaccine Immunol Volume: 21 Page(s): 1481 - 1489
    11/01/2014 Authors: Skountzou I; Satyabhama L; Stavropoulou A; Ashraf Z; Esser ES; Vassilieva E; Koutsonanos D; Compans R; Jacob J
  • Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2.
    Nature Volume: 509 Page(s): 381 - 384
    05/15/2014 Authors: Khan AG; Whidby J; Miller MT; Scarborough H; Zatorski AV; Cygan A; Price AA; Yost SA; Bohannon CD; Jacob J
  • Inducible nitric oxide synthase is crucial for plasma cell survival.
    Nat Immunol Volume: 15 Page(s): 219 - 221
    03/01/2014 Authors: Njau MN; Jacob J
  • The regulation of plasma cell function through soluble mediators of the CD28/B7 pathway
    Volume: 190
    05/01/2013 Authors: Holthausen D; Njau M; Jacob J
  • The CD28/B7 pathway: a novel regulator of plasma cell function.
    Adv Exp Med Biol Volume: 785 Page(s): 67 - 75
    01/01/2013 Authors: Njau MN; Jacob J
  • The enigma of memory B cells in malaria.
    Eur J Immunol Volume: 42 Page(s): 3146 - 3149
    12/01/2012 Authors: Njau MN; Jacob J
  • CD28-B7 interaction modulates short- and long-lived plasma cell function.
    J Immunol Volume: 189 Page(s): 2758 - 2767
    09/15/2012 Authors: Njau MN; Kim JH; Chappell CP; Ravindran R; Thomas L; Pulendran B; Jacob J
  • Hydrodynamic delivery of plasmid DNA encoding human FcR-Ig dimers blocks immune-complex mediated inflammation in mice.
    Gene Ther Volume: 19 Page(s): 877 - 885
    09/01/2012 Authors: Shashidharamurthy R; Machiah D; Bozeman EN; Srivatsan S; Patel J; Cho A; Jacob J; Selvaraj P
  • Strategies to alleviate original antigenic sin responses to influenza viruses.
    Proc Natl Acad Sci U S A Volume: 109 Page(s): 13751 - 13756
    08/21/2012 Authors: Kim JH; Davis WG; Sambhara S; Jacob J
  • Local response to microneedle-based influenza immunization in the skin.
    mBio Volume: 3 Page(s): e00012 - e00012
    01/01/2012 Authors: del Pilar Martin M; Weldon WC; Zarnitsyn VG; Koutsonanos DG; Akbari H; Skountzou I; Jacob J; Prausnitz MR; Compans RW
  • Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen.
    PLoS Pathog Volume: 7 Page(s): e1002220
    09/01/2011 Authors: Liang X; Paden CR; Morales FM; Powers RP; Jacob J; Speck SH
  • Serological memory and long-term protection to novel H1N1 influenza virus after skin vaccination.
    J Infect Dis Volume: 204 Page(s): 582 - 591
    08/15/2011 Authors: Koutsonanos DG; del Pilar Martin M; Zarnitsyn VG; Jacob J; Prausnitz MR; Compans RW; Skountzou I
  • Programming the magnitude and persistence of antibody responses with innate immunity.
    Nature Volume: 470 Page(s): 543 - 547
    02/24/2011 Authors: Kasturi SP; Skountzou I; Albrecht RA; Koutsonanos D; Hua T; Nakaya HI; Ravindran R; Stewart S; Alam M; Kwissa M
  • Immunity to pre-1950 H1N1 influenza viruses confers cross-protection against the pandemic swine-origin 2009 A (H1N1) influenza virus.
    J Immunol Volume: 185 Page(s): 1642 - 1649
    08/01/2010 Authors: Skountzou I; Koutsonanos DG; Kim JH; Powers R; Satyabhama L; Masseoud F; Weldon WC; Martin MDP; Mittler RS; Compans R
  • Immune complex-mediated enhancement of secondary antibody responses.
    J Immunol Volume: 184 Page(s): 6293 - 6298
    06/01/2010 Authors: Goins CL; Chappell CP; Shashidharamurthy R; Selvaraj P; Jacob J
  • Adjuvanted influenza vaccine administered intradermally elicits robust long-term immune responses that confer protection from lethal challenge.
    PLoS One Volume: 5 Page(s): e10897
    05/28/2010 Authors: Martin MDP; Seth S; Koutsonanos DG; Jacob J; Compans RW; Skountzou I
  • Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine.
    Vaccine Volume: 28 Page(s): 4103 - 4112
    05/28/2010 Authors: Skountzou I; Martin MDP; Wang B; Ye L; Koutsonanos D; Weldon W; Jacob J; Compans RW
  • Original antigenic sin responses to influenza viruses.
    J Immunol Volume: 183 Page(s): 3294 - 3301
    09/01/2009 Authors: Kim JH; Skountzou I; Compans R; Jacob J
  • Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties.
    Immunity Volume: 31 Page(s): 296 - 308
    08/21/2009 Authors: Rutishauser RL; Martins GA; Kalachikov S; Chandele A; Parish IA; Meffre E; Jacob J; Calame K; Kaech SM
  • Redemption from Original Antigenic Sin response to influenza virus
    Volume: 182
    04/01/2009 Authors: Kim JH; Jacob J
  • Naive B cells participate in secondary antibody response via immune complex mediated activation
    Volume: 182
    04/01/2009 Authors: Goins CL; Chappell CP; Murthy S; Selvaraj P; Jacob J
  • Perfusion fixation preserves enhanced yellow fluorescent protein and other cellular markers in lymphoid tissues.
    J Immunol Methods Volume: 340 Page(s): 116 - 122
    01/30/2009 Authors: Dauner JG; Chappell CP; Williams IR; Jacob J
  • DNA vaccines against influenza viruses.
    Curr Top Microbiol Immunol Volume: 333 Page(s): 197 - 210
    01/01/2009 Authors: Kim JH; Jacob J
  • Ontogeny of the secondary antibody response: origins and clonal diversity.
    Volume: 633 Page(s): 27 - 41
    01/01/2009 Authors: Chappell CP; Dauner J; Jacob J
  • Differential localization of memory B cell subsets
    FASEB JOURNAL Volume: 22
    04/01/2008 Authors: Dauner JG; Chappell CP; Jacob J
  • Differential microenvironment localization of effector and memory CD8 T cells.
    J Immunol Volume: 180 Page(s): 291 - 299
    01/01/2008 Authors: Dauner JG; Williams IR; Jacob J
  • Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent.
    J Clin Invest Volume: 117 Page(s): 3029 - 3041
    10/01/2007 Authors: Zhang B; Maris CH; Foell J; Whitmire J; Niu L; Song J; Kwon BS; Vella AT; Ahmed R; Jacob J
  • Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets.
    PLoS One Volume: 2 Page(s): e863
    09/12/2007 Authors: Gururajan M; Jacob J; Pulendran B
  • Interleukin-10 plays an early role in generating virus-specific T cell anergy.
    BMC Immunol Volume: 8 Page(s): 8
    06/14/2007 Authors: Maris CH; Chappell CP; Jacob J
  • Incorporation of glycosylphosphatidylinositol-anchored granulocyte- macrophage colony-stimulating factor or CD40 ligand enhances immunogenicity of chimeric simian immunodeficiency virus-like particles.
    J Virol Volume: 81 Page(s): 1083 - 1094
    02/01/2007 Authors: Skountzou I; Quan F-S; Gangadhara S; Ye L; Vzorov A; Selvaraj P; Jacob J; Compans RW; Kang S-M
  • Germinal-center-derived B-cell memory.
    Adv Exp Med Biol Volume: 590 Page(s): 139 - 148
    01/01/2007 Authors: Chappell CP; Jacob J
  • Transcutaneous immunization with inactivated influenza virus induces protective immune responses.
    Vaccine Volume: 24 Page(s): 6110 - 6119
    08/28/2006 Authors: Skountzou I; Quan F-S; Jacob J; Compans RW; Kang S-M
  • Identification of memory B cells using a novel transgenic mouse model.
    J Immunol Volume: 176 Page(s): 4706 - 4715
    04/15/2006 Authors: Chappell CP; Jacob J
  • DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T cell expansion.
    J Immunol Volume: 176 Page(s): 4562 - 4572
    04/15/2006 Authors: Chappell C; Beard C; Altman J; Jaenisch R; Jacob J
  • B lymphocytes participate in cross-presentation of antigen following gene gun vaccination.
    J Immunol Volume: 174 Page(s): 5233 - 5242
    05/01/2005 Authors: Hon H; Oran A; Brocker T; Jacob J
  • bcl-xL is critical for dendritic cell survival in vivo.
    J Immunol Volume: 173 Page(s): 4425 - 4432
    10/01/2004 Authors: Hon H; Rucker EB; Hennighausen L; Jacob J
  • The hybrid cytomegalovirus enhancer/chicken beta-actin promoter along with woodchuck hepatitis virus posttranscriptional regulatory element enhances the protective efficacy of DNA vaccines.
    J Immunol Volume: 173 Page(s): 550 - 558
    07/01/2004 Authors: Garg S; Oran AE; Hon H; Jacob J
  • Tracking dendritic cells in vivo: insights into DC biology and function.
    Immunol Res Volume: 29 Page(s): 69 - 80
    01/01/2004 Authors: Hon H; Jacob J
  • Genetic tagging shows increased frequency and longevity of antigen-presenting, skin-derived dendritic cells in vivo.
    Nat Immunol Volume: 4 Page(s): 907 - 912
    09/01/2003 Authors: Garg S; Oran A; Wajchman J; Sasaki S; Maris CH; Kapp JA; Jacob J
  • A transgenic mouse model genetically tags all activated CD8 T cells.
    J Immunol Volume: 171 Page(s): 2393 - 2401
    09/01/2003 Authors: Maris CH; Miller JD; Altman JD; Jacob J
  • Anti-CD137 treatment during the priming phase of an antiviral immune response results in CD8 T cell anergy and chronic infection
    Volume: 17 Page(s): C212 - C212
    04/14/2003 Authors: Maris CH; Foell J; McCausland M; Whitmire J; Ahmed R; Jacob J; Mittler RS
  • Neutralizing IL-10 during the early stages of a chronic viral infection results in transient augmentation of the immune response that ultimately fails to contain virus
    Volume: 17 Page(s): C229 - C229
    04/14/2003 Authors: Maris CH; Chappell C; Jacob J
  • Introduction: the complexities of T-cell heterogeneity.
    Microbes Infect Volume: 5 Page(s): 197 - 198
    03/01/2003 Authors: Chappell CP; Jacob J
  • Irreversible marking of dendritic cells in vivo: for contributed volumes.
    Adv Exp Med Biol Volume: 512 Page(s): 177 - 181
    01/01/2002 Authors: Garg S; Oran A; Maris C; Jaco J
  • Marking antigen-specific CD8 lymphocytes
    FASEB JOURNAL Volume: 14 Page(s): A1222 - A1222
    04/20/2000 Authors: Maris CH; Jacob J
  • Modelling T-cell memory by genetic marking of memory T cells in vivo.
    Nature Volume: 399 Page(s): 593 - 597
    06/10/1999 Authors: Jacob J; Baltimore D
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.
    J Exp Med Volume: 178 Page(s): 1293 - 1307
    10/01/1993 Authors: Jacob J; Przylepa J; Miller C; Kelsoe G
  • THE GERMINAL CENTER MICROENVIRONMENT DOES NOT ENSURE SOMATIC HYPERMUTATION
    JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 183 - 183
    01/26/1993 Authors: MILLER C; STEDRA J; JACOB J; CERNY J; KELSOE G
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.
    J Exp Med Volume: 176 Page(s): 679 - 687
    09/01/1992 Authors: Jacob J; Kelsoe G
  • In situ studies of the antigen-driven somatic hypermutation of immunoglobulin genes.
    Immunol Cell Biol Volume: 70 ( Pt 2) Page(s): 145 - 152
    04/01/1992 Authors: Jacob J; Miller C; Kelsoe G
  • INSITU STUDIES OF SOMATIC MUTATION IN RESPONSE TO T-DEPENDENT AND T-INDEPENDENT ANTIGENS
    FASEB JOURNAL Volume: 6 Page(s): A1136 - A1136
    02/26/1992 Authors: JACOB J; MILLER C; KELSOE G
  • Intraclonal generation of antibody mutants in germinal centres.
    Nature Volume: 354 Page(s): 389 - 392
    12/05/1991 Authors: Jacob J; Kelsoe G; Rajewsky K; Weiss U
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.
    J Exp Med Volume: 173 Page(s): 1165 - 1175
    05/01/1991 Authors: Jacob J; Kassir R; Kelsoe G
  • INSITU ANALYSIS OF A PRIMARY IMMUNE-RESPONSE
    FASEB JOURNAL Volume: 5 Page(s): A1004 - A1004
    03/15/1991 Authors: JACOB J; KELSOE G
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