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Profile

Jocelyn Grunwell

  • Department of Pediatrics
    Associate Professor
  • (404) 785-2311
  • jocelyn.grunwell@emory.edu
Head shot of Jocelyn Grunwell

Overview

Dr. Jocelyn R. Grunwell, MD, PhD is an Assistant Professor of Pediatrics in the Division of Critical Care Medicine at Emory University and Childrens Healthcare of Atlanta. Dr. Grunwell completed her undergraduate studies in chemistry at Harvard University. She then attended graduate school at the University of California, Berkeley where she received a PhD in Bio-organic Chemistry. After completing a post-doctoral fellowship in biochemistry at the University of California San Francisco, where she was a Damon Runyon post-doctoral fellow, she attended the Stanford University School of Medicine. She completed her Pediatrics Residency at Emory University in 2012. She was the Assistant Program Director (Chief Resident) for the Emory Pediatrics Residency program from 2012 - 2013. She completed her subspecialty fellowship training in pediatric critical care medicine at Emory in 2017 where she was a T32 post-doctoral fellow. From 2018 - 2020, Dr. Grunwell was an Atlanta Pediatric K12 Scholar. In 2020, Dr. Grunwell was awarded Junior Faculty Researcher of the Year. She is currently a NHLBI K23 awardee. Dr. Grunwell completed the postgraduate coursework for the Master of Science in Clinical and Translational Research (MSCR) degree at Emory in 2022.

Dr. Grunwells research focuses on the airway immune response in children who are at risk for developing and who are diagnosed with acute respiratory distress syndrome. She has a research program in immunophenotyping and determining patient-reported outcomes following life-threatening asthma exacerbations. She collaborates with engineers at the Georgia Institute of Technology to develop a lung-on-a-chip model and data scientists and machine learning experts at Emory/Georgia Tech to discover transcriptomic and metabolomic signatures of pediatric ARDS. In addition to her translational research, she participates in the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network and collaborates on multi-center observational and clinical trials to improve the care of critically ill children with ARDS (LEOPARDS), influenza (PICFLU2), sepsis (PROMPT-BOLUS), and multiple organ dysfunction (PARADIGM, TROPICS). She is a member of the SCCM Discover Research Network and the Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guideline committee.

In 2022, Dr. Grunwell became the Research Director for the Division of Pediatric Critical Care Medicine.

Focus of practice
Critical care medicine

Areas of interest
Pediatric acute respiratory distress syndrome
Critical and near-fatal asthma
Sepsis
Multiple Organ Dysfunction Syndrome
Social Determinants of Health

Professional affiliations
Society of Critical Care Medicine
American Association of Immunologists
American Thoracic Society
Pediatric Acute Lung Injury and Sepsis Investigators
Shock Society

Research interests
Understanding heterogeneity of complex critical illness syndromes with subphenotyping and endotyping strategies
Using machine learning to develop clinical prediction models and clinical decision support
Developing preclinical models that represent pediatric acute respiratory distress syndrome to identify underlying mechanisms, heterogeneity, and test interventions targeted at causal biological pathways

Research

Publications

  • High-throughput quantitation of human neutrophil recruitment and functional responses in an air-blood barrier array.
    APL Bioeng Volume: 9 Page(s): 026110
    06/01/2025 Authors: Viola H; Chen L-H; Jo S; Washington K; Selva C; Li A; Feng D; Giacalone V; Stephenson ST; Cottrill K
  • Development of an acute lung injury model for drug testing.
    Sci Rep Volume: 15 Page(s): 17703
    05/21/2025 Authors: Grunwell JR; Stephenson ST; Dallalio GA; Diani BA; Zaworski C; Jordan N; Fitzpatrick AM
  • Development of a Core Critical Care Data Dictionary With Common Data Elements to Characterize Critical Illness and Injuries Using a Modified Delphi Method.
    Crit Care Med Volume: 53 Page(s): e1045 - e1054
    05/01/2025 Authors: Murphy DJ; Anderson W; Heavner SH; Al-Hakim T; Cruz-Cano R; Laudanski K; Kamaleswaran R; Badawi O; Engel H; Grunwell J
  • The PICU Data Collaborative: A Novel, Multi-Institutional, Pediatric Critical Care Dataset.
    Pediatr Crit Care Med
    04/30/2025 Authors: Farris RWD; Shah SS; Bennett TD; Brown SR; Cornell TT; Dziorny AC; Flynn A; Grunwell J; Heneghan JA; Kennedy CE
  • Association of the child opportunity index with in-hospital mortality and persistence of organ dysfunction at one week after onset of Phoenix Sepsis among children admitted to the pediatric intensive care unit with suspected infection.
    PLOS Digit Health Volume: 4 Page(s): e0000763
    04/01/2025 Authors: Moore R; Chanci D; Brown SR; Ripple MJ; Bishop NR; Grunwell J; Kamaleswaran R
  • Tackling the small imbalanced horizontal dataset regressions by Stability Selection and SMOGN: a case study of ventilation-free days prediction in the pediatric intensive care unit and the importance of PRISM.
    Int J Med Inform Volume: 196 Page(s): 105809
    04/01/2025 Authors: Rad M; Rafiei A; Grunwell J; Kamaleswaran R
  • Asthma Phenotypes and Biomarkers.
    Respir Care
    02/10/2025 Authors: Grunwell JR; Fitzpatrick AM
  • PROGNOSTIC ACCURACY OF MACHINE LEARNING MODELS FOR IN-HOSPITAL MORTALITY AMONG CHILDREN WITH PHOENIX SEPSIS ADMITTED TO THE PEDIATRIC INTENSIVE CARE UNIT.
    Shock Volume: 63 Page(s): 80 - 87
    01/01/2025 Authors: Moore R; Chanci D; Brown S; Ripple MJ; Bishop NR; Grunwell J; Kamaleswaran R
  • RNA Sequencing Analysis of Monocytes Exposed to Airway Fluid From Children With Pediatric Acute Respiratory Distress Syndrome.
    Crit Care Explor Volume: 6 Page(s): e1125
    10/01/2024 Authors: Grunwell JR; Huang M; Stephenson ST; Tidwell M; Ripple MJ; Fitzpatrick AM; Kamaleswaran R
  • Clinical and inflammatory features of traffic-related diesel exposure in children with asthma.
    Ann Allergy Asthma Immunol Volume: 133 Page(s): 393 - 402.e4
    10/01/2024 Authors: Fitzpatrick AM; Mohammad AF; Desher K; Mutic AD; Stephenson ST; Dallalio GA; Grunwell JR
  • Assessing Social Determinants of Health During Critical Illness: Implications and Methodologies.
    Crit Care Clin Volume: 40 Page(s): 623 - 640
    10/01/2024 Authors: Magee PM; Asp RA; Myers CN; Grunwell JR; Paquette E; Akande MY
  • Association between comorbidities at ICU admission and post-Sepsis physical impairment: A retrospective cohort study.
    J Crit Care Volume: 83 Page(s): 154833
    10/01/2024 Authors: Kobara S; Yamamoto R; Rad MG; Grunwell JR; Hikota N; Uzawa Y; Hayashi Y; Coopersmith CM; Kamaleswaran R
  • Plasma metabolomics identifies differing endotypes of recurrent wheezing in preschool children differentiated by symptoms and social disadvantage.
    Sci Rep Volume: 14 Page(s): 15813
    07/09/2024 Authors: Fitzpatrick AM; Grunwell JR; Gaur H; Kobara S; Kamaleswaran R
  • HIGH THROUGHPUT QUANTITATION OF HUMAN NEUTROPHIL RECRUITMENT AND FUNCTIONAL RESPONSES IN AN AIR-BLOOD BARRIER ARRAY.
    bioRxiv
    05/14/2024 Authors: Viola H; Chen L-H; Jo S; Washington K; Selva C; Li A; Feng D; Giacalone V; Stephenson ST; Cottrill K
  • Dysfunctional neutrophil type 1 interferon responses in preschool children with recurrent wheezing and IL-4-mediated aeroallergen sensitization.
    J Allergy Clin Immunol Glob Volume: 3 Page(s): 100229
    05/01/2024 Authors: Fitzpatrick AM; Huang M; Mohammad AF; Stephenson ST; Kamaleswaran R; Grunwell JR
  • Environmental Injustice Is Associated With Poorer Asthma Outcomes in School-Age Children With Asthma in Metropolitan Atlanta, Georgia.
    J Allergy Clin Immunol Pract Volume: 12 Page(s): 1263 - 1272.e1
    05/01/2024 Authors: Grunwell JR; Mutic AD; Ezhuthachan ID; Mason C; Tidwell M; Caldwell C; Norwood J; Zack S; Jordan N; Fitzpatrick AM
  • Altered Symptom Perception in Children With Asthma Is Associated With Poor Childhood Opportunity and Adverse Outcomes.
    J Allergy Clin Immunol Pract Volume: 12 Page(s): 983 - 990
    04/01/2024 Authors: Fitzpatrick AM; Kavalieratos D; Vickery BP; Lee T; Mason C; Grunwell JR
  • Development and Validation of a Model for Endotracheal Intubation and Mechanical Ventilation Prediction in PICU Patients.
    Pediatr Crit Care Med Volume: 25 Page(s): 212 - 221
    03/01/2024 Authors: Chanci D; Grunwell JR; Rafiei A; Moore R; Bishop NR; Rajapreyar P; Lima LM; Mai M; Kamaleswaran R
  • Reply.
    J Allergy Clin Immunol Volume: 153 Page(s): 535
    02/01/2024 Authors: Fitzpatrick AM; Grunwell JR
  • So, You Say You Want a Revolution? You Tell Me That It's Evolution: Associating Temporal Changes in Pediatric Acute Respiratory Distress Syndrome Plasma Biomarkers With Lung Injury Severity.
    Pediatr Crit Care Med Volume: 25 Page(s): 80 - 83
    01/01/2024 Authors: Grunwell JR
  • Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness.
    EBioMedicine Volume: 99 Page(s): 104938
    01/01/2024 Authors: Atreya MR; Banerjee S; Lautz AJ; Alder MN; Varisco BM; Wong HR; Muszynski JA; Hall MW; Sanchez-Pinto LN; Kamaleswaran R
  • Frequency of HLA-DR+CD38hi T cells identifies and quantifies T-cell activation in hemophagocytic lymphohistiocytosis, hyperinflammation, and immune regulatory disorders.
    J Allergy Clin Immunol Volume: 153 Page(s): 309 - 319
    01/01/2024 Authors: Nguyen TH; Kumar D; Prince C; Martini D; Grunwell JR; Lawrence T; Whitely T; Chappelle K; Chonat S; Prahalad S
  • Functional immunophenotyping of blood neutrophils identifies novel endotypes of viral response in preschool children with recurrent wheezing.
    J Allergy Clin Immunol Volume: 152 Page(s): 1433 - 1443
    12/01/2023 Authors: Fitzpatrick AM; Mohammad AF; Huang M; Stephenson ST; Patrignani J; Kamaleswaran R; Grunwell JR
  • Outcomes of children with life-threatening status asthmaticus requiring isoflurane therapy and extracorporeal life support.
    J Asthma Volume: 60 Page(s): 1926 - 1934
    10/01/2023 Authors: Kolli S; Opolka C; Westbrook A; Gillespie S; Mason C; Truitt B; Kamat P; Fitzpatrick A; Grunwell JR
  • Metabolomics identifies disturbances in arginine, phenylalanine, and glycine metabolism as differentiating features of exacerbating atopic asthma in children.
    J Allergy Clin Immunol Glob Volume: 2
    08/01/2023 Authors: Cottrill KA; Chandler JD; Kobara S; Stephenson ST; Mohammad AF; Tidwell M; Mason C; Van Dresser M; Patrignani J; Kamaleswaran R
  • Poorer patient mental and social health is associated with worse respiratory outcomes in school-age children with pediatric intensive care use for life-threatening asthma.
    J Allergy Clin Immunol Pract Volume: 11 Page(s): 2595 - 2598
    08/01/2023 Authors: Grunwell JR; Tidwell M; Zack S; Najjar N; Fitzpatrick AM
  • Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock.
    Crit Care Volume: 27 Page(s): 260
    07/03/2023 Authors: Atreya MR; Cvijanovich NZ; Fitzgerald JC; Weiss SL; Bigham MT; Jain PN; Schwarz AJ; Lutfi R; Nowak J; Allen GL
  • RNA Sequencing Analysis of CD4+ T Cells Exposed to Airway Fluid From Children With Pediatric Acute Respiratory Distress Syndrome.
    Crit Care Explor Volume: 5 Page(s): e0935
    07/01/2023 Authors: Ripple MJ; Huang M; Stephenson ST; Mohammad AF; Tidwell M; Fitzpatrick AM; Kamaleswaran R; Grunwell JR
  • Social determinants of health influence preschool and caregiver experiences during symptoms and exacerbations of wheezing.
    Ann Allergy Asthma Immunol Volume: 131 Page(s): 75 - 81.e3
    07/01/2023 Authors: Fitzpatrick AM; Lee T; Vickery BP; Corace EA; Mason C; Norwood J; Caldwell C; Grunwell JR
  • Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1.
    Crit Care Volume: 27 Page(s): 250
    06/26/2023 Authors: Atreya MR; Cvijanovich NZ; Fitzgerald JC; Weiss SL; Bigham MT; Jain PN; Schwarz AJ; Lutfi R; Nowak J; Allen GL
  • Poorer Caregiver Mental and Social Health Is Associated With Worse Respiratory Outcomes in Preschool Children With Recurrent Wheezing.
    J Allergy Clin Immunol Pract Volume: 11 Page(s): 1814 - 1822
    06/01/2023 Authors: Fitzpatrick AM; Diani B; Kavalieratos D; Corace EA; Mason C; Van Dresser M; Grunwell JR
  • Blood Eosinophils for Prediction of Exacerbation in Preschool Children With Recurrent Wheezing.
    J Allergy Clin Immunol Pract Volume: 11 Page(s): 1485 - 1493.e8
    05/01/2023 Authors: Fitzpatrick AM; Grunwell JR; Cottrill KA; Mutic AD; Mauger DT
  • Cluster analysis of plasma cytokines identifies two unique endotypes of children with asthma in the pediatric intensive care unit.
    Sci Rep Volume: 13 Page(s): 3521
    03/02/2023 Authors: Cottrill KA; Rad MG; Ripple MJ; Stephenson ST; Mohammad AF; Tidwell M; Kamaleswaran R; Fitzpatrick AM; Grunwell JR
  • Association of Asthma With Treatments and Outcomes in Children With Critical Influenza.
    J Allergy Clin Immunol Pract Volume: 11 Page(s): 836 - 843.e3
    03/01/2023 Authors: Maddux AB; Grunwell JR; Newhams MM; Chen SR; Olson SM; Halasa NB; Weiss SL; Coates BM; Schuster JE; Hall MW
  • Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1.
    Res Sq
    02/03/2023 Authors: Atreya MR; Cvijanovich NZ; Fitzgerald JC; Weiss SL; Bigham MT; Jain PN; Schwarz AJ; Lutfi R; Nowak J; Allen GL
  • Pathobiology, Severity, and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.
    Pediatr Crit Care Med Volume: 24 Page(s): S12 - S27
    02/01/2023 Authors: Grunwell JR; Dahmer MK; Sapru A; Quasney MW; Flori H; Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
  • Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2).
    Pediatr Crit Care Med Volume: 24 Page(s): 143 - 168
    02/01/2023 Authors: Emeriaud G; Lpez-Fernndez YM; Iyer NP; Bembea MM; Agulnik A; Barbaro RP; Baudin F; Bhalla A; Brunow de Carvalho W; Carroll CL
  • Understanding clinical and biological heterogeneity to advance precision medicine in paediatric acute respiratory distress syndrome.
    Lancet Respir Med Volume: 11 Page(s): 197 - 212
    02/01/2023 Authors: Kneyber MCJ; Khemani RG; Bhalla A; Blokpoel RGT; Cruces P; Dahmer MK; Emeriaud G; Grunwell J; Ilia S; Katira BH
  • Identification of a pediatric acute hypoxemic respiratory failure signature in peripheral blood leukocytes at 24 hours post-ICU admission with machine learning.
    Front Pediatr Volume: 11 Page(s): 1159473
    01/01/2023 Authors: Grunwell JR; Rad MG; Ripple MJ; Yehya N; Wong HR; Kamaleswaran R
  • Expression Patterns of Airway Fluid Cytokines From Intubated Children With Pediatric Acute Respiratory Distress Syndrome.
    Crit Care Explor Volume: 4 Page(s): e0819
    12/01/2022 Authors: Ripple MJ; Mohammad AF; Stephenson ST; Fitzpatrick AM; Grunwell JR
  • Bioenergetic Crisis in ICU-Acquired Weakness Gene Signatures Was Associated With Sepsis-Related Mortality: A Brief Report.
    Crit Care Explor Volume: 4 Page(s): e0818
    12/01/2022 Authors: Kobara S; Rad MG; Grunwell JR; Coopersmith CM; Kamaleswaran R
  • Functional immunophenotyping of children with critical status asthmaticus identifies differential gene expression responses in neutrophils exposed to a poly(I:C) stimulus.
    Sci Rep Volume: 12 Page(s): 19644
    11/16/2022 Authors: Grunwell JR; Rad MG; Stephenson ST; Mohammad AF; Opolka C; Fitzpatrick AM; Kamaleswaran R
  • Geospatial Analysis of Social Determinants of Health Identifies Neighborhood Hot Spots Associated With Pediatric Intensive Care Use for Acute Respiratory Failure Requiring Mechanical Ventilation.
    Pediatr Crit Care Med Volume: 23 Page(s): 606 - 617
    08/01/2022 Authors: Najjar N; Opolka C; Fitzpatrick AM; Grunwell JR
  • Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospectiveobservationalstudy.
    Crit Care Volume: 26 Page(s): 210
    07/11/2022 Authors: Atreya MR; Cvijanovich NZ; Fitzgerald JC; Weiss SL; Bigham MT; Jain PN; Schwarz AJ; Lutfi R; Nowak J; Allen GL
  • Social Vulnerability Is Associated with Poorer Outcomes in Preschool Children With Recurrent Wheezing Despite Standardized and Supervised Medical Care.
    J Allergy Clin Immunol Pract Volume: 10 Page(s): 994 - 1002
    04/01/2022 Authors: Mutic AD; Mauger DT; Grunwell JR; Opolka C; Fitzpatrick AM
  • Geospatial Analysis of Social Determinants of Health Identifies Neighborhood Hot Spots Associated With Pediatric Intensive Care Use for Life-Threatening Asthma.
    J Allergy Clin Immunol Pract Volume: 10 Page(s): 981 - 991.e1
    04/01/2022 Authors: Grunwell JR; Opolka C; Mason C; Fitzpatrick AM
  • Obesity Is Associated with Sustained Symptomatology and Unique Inflammatory Features in Children with Asthma.
    J Allergy Clin Immunol Pract Volume: 10 Page(s): 815 - 826.e2
    03/01/2022 Authors: Fitzpatrick AM; Mutic AD; Mohammad AF; Stephenson ST; Grunwell JR
  • Adverse Childhood Experiences and Patient-Reported Outcome Measures in Critically Ill Children.
    Front Pediatr Volume: 10 Page(s): 923118
    01/01/2022 Authors: Rodenbough A; Opolka C; Wang T; Gillespie S; Ververis M; Fitzpatrick AM; Grunwell JR
  • THE ASSOCIATION OF NEIGHBORHOOD SOCIAL VULNERABILITY AND PEDIATRIC ACUTE RESPIRATORY FAILURE
    Volume: 50 Page(s): 26 - 26
    01/01/2022 Authors: Najjar N; Fitzpatrick A; Grunwell J
  • CLUSTER ANALYSIS AND PROFILING OF AIRWAY FLUID METABOLITES IN PEDIATRIC ARDS
    Volume: 50 Page(s): 584 - 584
    01/01/2022 Authors: Ripple M; Rad M; Stephenson S; Mohammad A; Opolka C; Fitzpatrick A; Kamaleswaran R; Grunwell J
  • ADVERSE CHILDHOOD EXPERIENCES ARE ASSOCIATED WITH PATIENT-REPORTED OUTCOMES IN CRITICALLY ILL KIDS
    Volume: 50 Page(s): 235 - 235
    01/01/2022 Authors: Rodenbough A; Opolka C; Ververis M; Grunwell J
  • FUTURE OF PEDIATRIC CRITICAL CARE REMOTE LEARNING: ROLE AND REACH OF A PODCAST SERIES
    Volume: 50 Page(s): 279 - 279
    01/01/2022 Authors: Damania R; Price C; Grunwell J; Kamat P
  • INTEGRATING PODCASTS INTO PEDIATRIC CRITICAL CARE EDUCATION: REACH OF "PICU DOC ON CALL" PODCASTS
    Volume: 50 Page(s): 278 - 278
    01/01/2022 Authors: Damania R; Austin T; Grunwell J; Kamat P
  • A High-Throughput Distal Lung Air-Blood Barrier Model Enabled By Density-Driven Underside Epithelium Seeding.
    Adv Healthc Mater Volume: 11 Page(s): e2102450
    01/01/2022 Authors: Viola H; Washington K; Selva C; Grunwell J; Tirouvanziam R; Takayama S
  • Cluster analysis and profiling of airway fluid metabolites in pediatric acute hypoxemic respiratory failure.
    Sci Rep Volume: 11 Page(s): 23019
    11/26/2021 Authors: Grunwell JR; Rad MG; Stephenson ST; Mohammad AF; Opolka C; Fitzpatrick AM; Kamaleswaran R
  • A High-Throughput Distal Lung Air-Blood Barrier Model Enabled By Density-Driven Underside Epithelium Seeding.
    Adv Healthc Mater Volume: 10 Page(s): e2100879
    08/01/2021 Authors: Viola H; Washington K; Selva C; Grunwell J; Tirouvanziam R; Takayama S
  • Recalibration of the Renal Angina Index for Pediatric Septic Shock.
    Kidney Int Rep Volume: 6 Page(s): 1858 - 1867
    07/01/2021 Authors: Stanski NL; Wong HR; Basu RK; Cvijanovich NZ; Fitzgerald JC; Weiss SL; Bigham MT; Jain PN; Schwarz A; Lutfi R
  • Performance of Eosinophil Cationic Protein as a Biomarker in Asthmatic Children.
    J Allergy Clin Immunol Pract Volume: 9 Page(s): 2761 - 2769.e2
    07/01/2021 Authors: Shah SN; Grunwell JR; Mohammad AF; Stephenson ST; Lee GB; Vickery BP; Fitzpatrick AM
  • Machine Learning-Based Discovery of a Gene Expression Signature in Pediatric Acute Respiratory Distress Syndrome.
    Crit Care Explor Volume: 3 Page(s): e0431
    06/01/2021 Authors: Grunwell JR; Rad MG; Stephenson ST; Mohammad AF; Opolka C; Fitzpatrick AM; Kamaleswaran R
  • Hexosylceramides and Glycerophosphatidylcholine GPC(36:1) Increase in Multi-Organ Dysfunction Syndrome Patients with Pediatric Intensive Care Unit Admission over 8-Day Hospitalization.
    J Pers Med Volume: 11
    04/24/2021 Authors: Leimanis-Laurens M; Wolfrum E; Ferguson K; Grunwell JR; Sanfilippo D; Prokop JW; Lydic TA; Rajasekaran S
  • The microbiome and the immune system in critical illness.
    Curr Opin Crit Care Volume: 27 Page(s): 157 - 163
    04/01/2021 Authors: Miniet AA; Grunwell JR; Coopersmith CM
  • Adult opioid poisonings by drug, intent, and resource use from the United States National Poison Data System from 2005-2018.
    Clin Toxicol (Phila) Volume: 59 Page(s): 142 - 151
    02/01/2021 Authors: Land ME; Wetzel M; Geller RJ; Steck AR; Grunwell JR
  • Preventing asthma in high risk kids (PARK) with omalizumab: Design, rationale, methods, lessons learned and adaptation.
    Contemp Clin Trials Volume: 100 Page(s): 106228
    01/01/2021 Authors: Phipatanakul W; Mauger DT; Guilbert TW; Bacharier LB; Durrani S; Jackson DJ; Martinez FD; Fitzpatrick AM; Cunningham A; Kunselman S
  • LATENT CLASS ANALYSIS OF PEDIATRIC PATIENTS WITH NEAR-FATAL ASTHMA
    Volume: 49 Page(s): 484 - 484
    01/01/2021 Authors: Kolli S; Rodenbough A; Jones K; Mason C; Opolka C; Grunwell J; Fitzpatrick A
  • CHANGES IN SPHINGOLIPIDS AND GLYCEROPHOSPHOTIDYLCHOLINE IN MULTIORGAN DYSFUNCTION SYNDROME PATIENTS
    Volume: 49 Page(s): 311 - 311
    01/01/2021 Authors: Leimanis M; Wolfrum E; Ferguson K; Grunwell J; Sanfilippo D; Prokop J; Lydic T; Rajasekaran S
  • Differential type I interferon response and primary airway neutrophil extracellular trap release in children with acute respiratory distress syndrome.
    Sci Rep Volume: 10 Page(s): 19049
    11/04/2020 Authors: Grunwell JR; Stephenson ST; Mohammad AF; Jones K; Mason C; Opolka C; Fitzpatrick AM
  • Critical care resource use, cost, and mortality associated with firearm-related injuries in US children's hospitals.
    J Pediatr Surg Volume: 55 Page(s): 2475 - 2479
    11/01/2020 Authors: Kamat PP; Santore MT; Hoops KEM; Wetzel M; McCracken C; Sullivan D; Hall M; Grunwell JR
  • Analysis of 207,543 children with acute opioid poisonings from the United States National Poison Data System.
    Clin Toxicol (Phila) Volume: 58 Page(s): 829 - 836
    08/01/2020 Authors: Land ME; Wetzel M; Geller RJ; Kamat PP; Grunwell JR
  • Severe acute kidney injury is independently associated with mortality in children with septic shock.
    Intensive Care Med Volume: 46 Page(s): 1050 - 1051
    05/01/2020 Authors: Stanski NL; Cvijanovich NZ; Fitzgerald JC; Bigham MT; Wong HR; Genomics of Pediatric Septic Shock Investigators
  • PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock.
    Am J Respir Crit Care Med Volume: 201 Page(s): 848 - 855
    04/01/2020 Authors: Stanski NL; Stenson EK; Cvijanovich NZ; Weiss SL; Fitzgerald JC; Bigham MT; Jain PN; Schwarz A; Lutfi R; Nowak J
  • Bronchodilator Dose Responsiveness in Children and Adolescents: Clinical Features and Association with Future Asthma Exacerbations.
    J Allergy Clin Immunol Pract Volume: 8 Page(s): 953 - 964
    03/01/2020 Authors: Grunwell JR; Nguyen KM; Bruce AC; Fitzpatrick AM
  • ANALYSIS OF 207,543 CHILDREN WITH ACUTE OPIOID INGESTIONS FROM THE NATIONAL POISON DATA SYSTEM
    Volume: 48
    01/01/2020 Authors: Land M; Wetzel M; Geller R; Kamat P; Grunwell J
  • DOES ONE PILL REALLY KILL? ANALYSIS OF 10,192 PRESCHOOL CHILDREN WITH HIGH-POTENCY INGESTIONS
    Volume: 48
    01/01/2020 Authors: Land M; Wetzel M; Geller R; Grunwell J
  • NONINVASIVE DIFFUSE OPTICS FOR CEREBRAL HEMODYNAMIC MONITORING IN CHILDREN AFTER CARDIAC ARREST
    Volume: 48
    01/01/2020 Authors: Atlas N; Cowdrick K; Chance K; Sathialingam E; Lee S; Fang Z; Liew A; Brothers R; Wolf M; Grunwell J
  • Latent Class Analysis of School-Age Children at Risk for Asthma Exacerbation.
    J Allergy Clin Immunol Pract Volume: 8 Page(s): 2275 - 2284.e2
    01/01/2020 Authors: Grunwell JR; Gillespie S; Morris CR; Fitzpatrick AM
  • Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair.
    APL Bioeng Volume: 3 Page(s): 041503
    12/01/2019 Authors: Viola H; Chang J; Grunwell JR; Hecker L; Tirouvanziam R; Grotberg JB; Takayama S
  • Prospective evaluation of a clinical decision tool to reduce childhood admissions to PICUs for poisoning: ReCAP2.
    Clin Toxicol (Phila) Volume: 57 Page(s): 1137 - 1141
    12/01/2019 Authors: Grunwell JR; McCracken CE; Travers CD; Geller RJ; Kamat PP
  • Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model.
    Sci Transl Med Volume: 11
    11/13/2019 Authors: Wong HR; Caldwell JT; Cvijanovich NZ; Weiss SL; Fitzgerald JC; Bigham MT; Jain PN; Schwarz A; Lutfi R; Nowak J
  • Therapeutic Plasma Exchange in Children With Thrombocytopenia-Associated Multiple Organ Failure: The Thrombocytopenia-Associated Multiple Organ Failure Network Prospective Experience.
    Crit Care Med Volume: 47 Page(s): e173 - e181
    03/01/2019 Authors: Fortenberry JD; Nguyen T; Grunwell JR; Aneja RK; Wheeler D; Hall M; Fleming G; Tarrago R; Buttram S; Dalton H
  • Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections.
    Sci Rep Volume: 9 Page(s): 2874
    02/27/2019 Authors: Grunwell JR; Giacalone VD; Stephenson S; Margaroli C; Dobosh BS; Brown MR; Fitzpatrick AM; Tirouvanziam R
  • Children with Neutrophil-Predominant Severe Asthma Have Proinflammatory Neutrophils With Enhanced Survival and Impaired Clearance.
    J Allergy Clin Immunol Pract Volume: 7 Page(s): 516 - 525.e6
    02/01/2019 Authors: Grunwell JR; Stephenson ST; Tirouvanziam R; Brown LAS; Brown MR; Fitzpatrick AM
  • SEDATION VERSUS GENERAL ANESTHESIA FOR PROCEDURES IN PEDIATRIC PATIENTS WITH SLEEP-RELATED CONCERNS
    Volume: 47
    01/01/2019 Authors: Miniet A; Karaga K; Grunwell J; Mc-Cracken C; Simon H; Guglani L; Kamat P
  • A NURSING SCREENING TOOL TO ASSESS A CHILD's APPROPRIATENESS FOR SEDATION VERSUS NEED FOR ANESTHESIA
    Volume: 47
    01/01/2019 Authors: Balkam K; Kamat P; Grunwell J; Mallory M; Thompson B
  • A RESIDENT SCREENING TOOL TO ASSESS PEDIATRIC APPROPRIATENESS FOR SEDATION VERSUS ANESTHESIA
    Volume: 47
    01/01/2019 Authors: Balkam K; Kamat P; Grunwell J; Cooley A; Singer K; Thompson B
  • Exploring the Utility of Noninvasive Type 2 Inflammatory Markers for Prediction of Severe Asthma Exacerbations in Children and Adolescents.
    J Allergy Clin Immunol Pract Volume: 7 Page(s): 2624 - 2633.e2
    01/01/2019 Authors: Shah SP; Grunwell J; Shih J; Stephenson S; Fitzpatrick AM
  • Inflammatory and Comorbid Features of Children Admitted to a PICU for Status Asthmaticus.
    Pediatr Crit Care Med Volume: 19 Page(s): e585 - e594
    11/01/2018 Authors: Grunwell JR; Travers C; Fitzpatrick AM
  • Hyperchloremia is associated with acute kidney injury in pediatric patients with septic shock.
    Intensive Care Med Volume: 44 Page(s): 2004 - 2005
    11/01/2018 Authors: Stenson EK; Cvijanovich NZ; Allen GL; Thomas NJ; Bigham MT; Weiss SL; Fitzgerald JC; Jain PN; Meyer K; Quasney M
  • Procedural sedation in children with autism spectrum disorders: A survey of current practice patterns of the society for pediatric sedation members.
    Paediatr Anaesth Volume: 28 Page(s): 552 - 557
    06/01/2018 Authors: Kamat PP; Bryan LN; McCracken CE; Simon HK; Berkenbosch JW; Grunwell JR
  • Outpatient Procedural Sedation of Patients With Autism Spectrum Disorders for Magnetic Resonance Imaging of the Brain Using Propofol.
    J Child Neurol Volume: 33 Page(s): 313 - 319
    04/01/2018 Authors: Kamat PP; Karaga MK; Wisniewski BL; McCracken CE; Simon HK; Sidhu R; Grunwell JR
  • TGF-1 Suppresses the Type I IFN Response and Induces Mitochondrial Dysfunction in Alveolar Macrophages.
    J Immunol Volume: 200 Page(s): 2115 - 2128
    03/15/2018 Authors: Grunwell JR; Yeligar SM; Stephenson S; Ping XD; Gauthier TW; Fitzpatrick AM; Brown LAS
  • Endotype Transitions During the Acute Phase of Pediatric Septic Shock Reflect Changing Risk and Treatment Response.
    Crit Care Med Volume: 46 Page(s): e242 - e249
    03/01/2018 Authors: Wong HR; Cvijanovich NZ; Anas N; Allen GL; Thomas NJ; Bigham MT; Weiss SL; Fitzgerald JC; Checchia PA; Meyer K
  • Hyperchloremia Is Associated With Complicated Course and Mortality in Pediatric Patients With Septic Shock.
    Pediatr Crit Care Med Volume: 19 Page(s): 155 - 160
    02/01/2018 Authors: Stenson EK; Cvijanovich NZ; Anas N; Allen GL; Thomas NJ; Bigham MT; Weiss SL; Fitzgerald JC; Checchia PA; Meyer K
  • Reducing Childhood Admissions to the PICU for Poisoning (ReCAP2) by Predicting Unnecessary PICU Admissions After Acute Intoxication.
    Pediatr Crit Care Med Volume: 19 Page(s): e120 - e129
    02/01/2018 Authors: Patel MM; Travers CD; Stockwell JA; Numur EA; Geller RJ; Kamat PP; Grunwell JR
  • Factors affecting same-day cancelation of outpatient pediatric oncologic procedural sedation.
    Pediatr Hematol Oncol Volume: 35 Page(s): 309 - 315
    01/01/2018 Authors: Grunwell JR; Long LD; Bryan LN; Kelley T; Sabnis HS; Simon HK; Kamat PP
  • Vitamin D deficiency is associated with an oxidized plasma cysteine redox potential in critically Ill children.
    J Steroid Biochem Mol Biol Volume: 175 Page(s): 164 - 169
    01/01/2018 Authors: Alvarez JA; Grunwell JR; Gillespie SE; Tangpricha V; Hebbar KB
  • A SURVEY OF PROCEDURAL SEDATION IN CHILDREN WITH AUTISM SPECTRUM DISORDERS
    Volume: 46 Page(s): 222 - 222
    01/01/2018 Authors: Patel M; Grunwell J; Bryan L; McCracken C; Dave I; Stockwell J; Berkenbosch J; Simon H; Kamat P
  • Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP.
    Am J Respir Crit Care Med Volume: 196 Page(s): 494 - 501
    08/15/2017 Authors: Wong HR; Cvijanovich NZ; Anas N; Allen GL; Thomas NJ; Bigham MT; Weiss SL; Fitzgerald JC; Checchia PA; Meyer K
  • Predictors of emergency department use in children with persistent asthma in metropolitan Atlanta, Georgia.
    Ann Allergy Asthma Immunol Volume: 119 Page(s): 129 - 136
    08/01/2017 Authors: Franklin JM; Grunwell JR; Bruce AC; Smith RC; Fitzpatrick AM
  • Trend and Outcomes of Video Laryngoscope Use Across PICUs.
    Pediatr Crit Care Med Volume: 18 Page(s): 741 - 749
    08/01/2017 Authors: Grunwell JR; Kamat PP; Miksa M; Krishna A; Walson K; Simon D; Krawiec C; Breuer R; Lee JH; Gradidge E
  • Pediatric Procedural Sedation Using the Combination of Ketamine and Propofol Outside of the Emergency Department: A Report From the Pediatric Sedation Research Consortium.
    Pediatr Crit Care Med Volume: 18 Page(s): e356 - e363
    08/01/2017 Authors: Grunwell JR; Travers C; Stormorken AG; Scherrer PD; Chumpitazi CE; Stockwell JA; Roback MG; Cravero J; Kamat PP
  • Analysis of Interventions Required in 12,021 Children With Acute Intoxications Admitted to PICUs.
    Pediatr Crit Care Med Volume: 18 Page(s): e281 - e289
    07/01/2017 Authors: Patel MM; Travers CD; Stockwell JA; Geller RJ; Kamat PP; Grunwell JR
  • Glucocorticoid Receptor Polymorphisms and Outcomes in Pediatric Septic Shock.
    Pediatr Crit Care Med Volume: 18 Page(s): 299 - 303
    04/01/2017 Authors: Cvijanovich NZ; Anas N; Allen GL; Thomas NJ; Bigham MT; Weiss SL; Fitzgerald J; Checchia PA; Meyer K; Quasney M
  • Impaired defenses of neonatal mouse alveolar macrophage with cftr deletion are modulated by glutathione and TGF1.
    Physiol Rep Volume: 5
    03/01/2017 Authors: Gauthier TW; Grunwell JR; Ping X-D; Harris FL; Brown LAS
  • MITOCHONDRIAL FUNCTION IN ALVEOLAR MACROPHAGES IS IMPAIRED IN HIV-1 TRANSGENIC RATS VIA A PPAR gamma-DEPENDENT PATHWAY
    Volume: 65 Page(s): 616 - 616
    02/01/2017 Authors: Staitieh B; Grunwell J; Fan X; Guidot D; Yeligar S
  • Respiratory Syncytial Virus Decreases The Metabolic Potential And Spare Respiratory Capacity Of Mouse Alveolar Macrophages
    Volume: 195
    01/01/2017 Authors: Grunwell JR; Yeligar SM; Gauthier TW; Brown L
  • Mitochondrial Function In Alveolar Macrophages Is Impaired In Hiv-1 Transgenic Rats Via A Ppar-gamma-Dependent Pathway
    Volume: 195
    01/01/2017 Authors: Staitieh BS; Grunwell JR; Fan X; Guidot DM; Yeligar SM
  • Alcohol Dysregulates Mitochondrial Morphology And Function In Alveolar Macrophages
    Volume: 195
    01/01/2017 Authors: Grunwell JR; Yeligar S
  • ReCAP2: reducing childhood admissions to the PICU for poisoning by predicting unnecessary PICU admissions after acute ingestion
    Volume: 55 Page(s): 707 - 708
    01/01/2017 Authors: Patel M; Travers C; Numur E; Geller R; Kamat P; Grunwell J
  • ANALYSIS OF 10,300 CHILDREN WITH ACUTE INGESTIONS TO DETERMINE RISK FACTORS FOR PICU PROCEDURES
    Volume: 44
    12/01/2016 Authors: Patel M; Travers C; Stockwell J; Kamat P; Grunwell J
  • WHICH CHILDREN NEED PICU CARE AFTER INGESTION? PREDICTION MODEL BASED ON NATIONAL POISON DATA
    Volume: 44
    12/01/2016 Authors: Patel M; Travers C; Geller R; Stockwell J; Kamat P; Grunwell J
  • Procedural Sedation Outside of the Operating Room Using Ketamine in 22,645 Children: A Report From the Pediatric Sedation Research Consortium.
    Pediatr Crit Care Med Volume: 17 Page(s): 1109 - 1116
    12/01/2016 Authors: Grunwell JR; Travers C; McCracken CE; Scherrer PD; Stormorken AG; Chumpitazi CE; Roback MG; Stockwell JA; Kamat PP
  • Outcomes following implementation of a pediatric procedural sedation guide for referral to general anesthesia for magnetic resonance imaging studies.
    Paediatr Anaesth Volume: 26 Page(s): 628 - 636
    06/01/2016 Authors: Grunwell JR; Marupudi NK; Gupta RV; Travers CD; McCracken CE; Williamson JL; Stockwell JA; Fortenberry JD; Couloures K; Cravero J
  • Relationship Between Vitamin D Status and Plasma Aminothiol Redox in Critically Ill Children
    Volume: 30
    04/01/2016 Authors: Alvarez JA; Grunwell JR; Gillespie SE; Tangpricha V; Hebbar K
  • TREND AND OUTCOMES OF VIDEO LARYNGOSCOPE USE ACROSS PICUS
    Volume: 43
    12/01/2015 Authors: Grunwell J; Kamat P; Walson K; Krishna A; Gradidge E; Nadkarni V; Nishisaki A
  • Differential expression of the Nrf2-linked genes in pediatric septic shock.
    Crit Care Volume: 19 Page(s): 327
    09/17/2015 Authors: Grunwell JR; Weiss SL; Cvijanovich NZ; Allen GL; Thomas NJ; Freishtat RJ; Anas N; Meyer K; Checchia PA; Shanley TP
  • Comments on Baranwal et al: dexamethasone pretreatment for 24 h versus 6 h for prevention of postextubation airway obstruction in children.
    Intensive Care Med Volume: 41 Page(s): 375
    02/01/2015 Authors: Grunwell J
  • Comparison of Glutathione, Cysteine, and Their Redox Potentials in the Plasma of Critically Ill and Healthy Children.
    Front Pediatr Volume: 3 Page(s): 46
    01/01/2015 Authors: Grunwell JR; Gillespie SE; Ward JM; Fitzpatrick AM; Brown LA; Gauthier TW; Hebbar KB
  • OXIDATIVE STRESS IS ELEVATED IN THE PLASMA OF CRITICALLY ILL CHILDREN
    CRITICAL CARE MEDICINE Volume: 42
    12/01/2014 Authors: Grunwell J; Gillespie S; Ward J; Fitzpatrick A; Brown LA; Gauthier T; Hebbar K
  • Risk factors leading to failed procedural sedation in children outside the operating room.
    Pediatr Emerg Care Volume: 30 Page(s): 381 - 387
    06/01/2014 Authors: Grunwell JR; McCracken C; Fortenberry J; Stockwell J; Kamat P
  • Targeting tat inhibitors in the assembly of human immunodeficiency virus type 1 transcription complexes.
    J Virol Volume: 82 Page(s): 9492 - 9504
    10/01/2008 Authors: D'Orso I; Grunwell JR; Nakamura RL; Das C; Frankel AD
  • Extent of disease and practice patterns for medullary thyroid cancer.
    J Am Coll Surg Volume: 200 Page(s): 890 - 896
    06/01/2005 Authors: Kebebew E; Greenspan FS; Clark OH; Woeber KA; Grunwell J
  • Constructing azide-labeled cell surfaces using polysaccharide biosynthetic pathways.
    Methods Enzymol Volume: 362 Page(s): 249 - 272
    01/01/2003 Authors: Luchansky SJ; Hang HC; Saxon E; Grunwell JR; Yu C; Dube DH; Bertozzi CR
  • Characterization and mutagenesis of Gal/GlcNAc-6-O-sulfotransferases.
    Biochemistry Volume: 41 Page(s): 15590 - 15600
    12/31/2002 Authors: Grunwell JR; Rath VL; Rasmussen J; Cabrilo Z; Bertozzi CR
  • Carbohydrate sulfotransferases of the GalNAc/Gal/GlcNAc6ST family.
    Biochemistry Volume: 41 Page(s): 13117 - 13126
    11/05/2002 Authors: Grunwell JR; Bertozzi CR
  • Monitoring the conformational fluctuations of DNA hairpins using single-pair fluorescence resonance energy transfer.
    J Am Chem Soc Volume: 123 Page(s): 4295 - 4303
    05/09/2001 Authors: Grunwell JR; Glass JL; Lacoste TD; Deniz AA; Chemla DS; Schultz PG
  • Single-pair fluorescence resonance energy transfer on freely diffusing molecules: observation of Frster distance dependence and subpopulations.
    Proc Natl Acad Sci U S A Volume: 96 Page(s): 3670 - 3675
    03/30/1999 Authors: Deniz AA; Dahan M; Grunwell JR; Ha T; Faulhaber AE; Chemla DS; Weiss S; Schultz PG
  • Ratiometric measurements on single molecules: towards identification of biomolecule conformations
    Volume: 76 Page(s): A168 - A168
    01/01/1999 Authors: Dahan M; Deniz AA; Ha T; Grunwell JR; Chemla DS; Schultz PC; Weiss S
  • Induced conformational dynamics of single DNA hairpin molecules
    Volume: 76 Page(s): A110 - A110
    01/01/1999 Authors: Lacoste TD; Laurence T; Grunwell JR; Glass J; Chemla DS; Schultz PG; Weiss S
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