Jennifer Felger PhD

Department of Psychiatry and Behavioral Sciences
Associate Professor

(404) 727-3987
jfelger@emory.edu

Academic Appointment

Associate Professor, Psychiatry and Behavioral Sciences, Emory University School of Medicine

Education

Degrees

Masters in Clinical Research from Emory University
PhD from Emory University
BS from University of Florida

Research

Focus

My research interests are on the impact of inflammatory cytokines on the brain and behavior, in relationship to neuropsychiatric illnesses including depression and fatigue. My work combines both basic and clinical approaches to understanding mechanisms of cytokine effects on neurotransmitter systems in the brain to identify novel therapeutic strategies.

Publications

Inflammation is associated with avolition and reduced resting state functional connectivity in corticostriatal reward circuitry in patients with schizophrenia.
Neuropsychopharmacology
04/24/2025 Authors: Goldsmith DR; Ning CS; Strauss GP; Gross RE; Cooper JA; Wommack EC; Haroon E; Felger JC; Walker EF; Treadway MT
Not All Neuroinflammation Is Created Equal: The Dual Nature of Astrogliosis.
Biol Psychiatry Volume: 97 Page(s): 758 - 760
04/15/2025 Authors: Haroon E; Felger JC; Miller AH
Designing Clinical Trials for an Inflammatory Subtype of Major Depressive Disorder.
Biol Psychiatry
04/10/2025 Authors: Miller AH; Felger JC; Haroon E
A randomized proof-of-mechanism trial of TNF antagonism for motivational deficits and related corticostriatal circuitry in depressed patients with high inflammation.
Mol Psychiatry Volume: 30 Page(s): 1407 - 1417
04/01/2025 Authors: Treadway MT; Etuk SM; Cooper JA; Hossein S; Hahn E; Betters SA; Liu S; Arulpragasam AR; DeVries BAM; Irfan N
Neurotransmitter and metabolic effects of interferon-alpha in association with decreased striatal dopamine in a non-human primate model of cytokine-Induced depression.
Brain Behav Immun Volume: 125 Page(s): 308 - 318
03/01/2025 Authors: Bekhbat M; Block AM; Dickinson SY; Tharp GK; Bosinger SE; Felger JC
Sustained effects of repeated levodopa (L-DOPA) administration on reward circuitry, effort-based motivation, and anhedonia in depressed patients with higher inflammation.
Brain Behav Immun Volume: 125 Page(s): 240 - 248
03/01/2025 Authors: Bekhbat M; Li Z; Dunlop BW; Treadway MT; Mehta ND; Revill KP; Lucido MJ; Hong C; Ashchi A; Wommack EC
Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression.
Compr Psychoneuroendocrinol Volume: 21 Page(s): 100284
02/01/2025 Authors: Singh A; Bekhbat M; Goldsmith DR; Le N-A; Wommack EC; Li Z; Haroon E; Felger JC
DNA methylation profiles of cancer-related fatigue associated with markers of inflammation and immunometabolism.
Mol Psychiatry Volume: 30 Page(s): 76 - 83
01/01/2025 Authors: Xiao C; Peng G; Conneely KN; Zhao H; Felger JC; Wommack EC; Higgins KA; Shin DM; Saba NF; Bruner DW
A randomized proof-of-mechanism trial of TNF antagonism for motivational anhedonia and related corticostriatal circuitry in depressed patients with high inflammation.

03/05/2024 Authors: Treadway M; Etuk S; Cooper J; Hossein S; Hahn E; Betters S; Liu S; Arulpragasam A; DeVries B; Irfan N
C-reactive protein moderates associations between racial discrimination and ventromedial prefrontal cortex activation during attention to threat in Black American women.
Neuropsychopharmacology Volume: 49 Page(s): 593 - 599
02/01/2024 Authors: Elbasheir A; Felger JC; Michopoulos V; Ely TD; Wommack EC; Carter SE; Harnett NG; Fani N
Cerebrospinal fluid levels of 5-HIAA and dopamine in people with HIV and depression.
J Neurovirol Volume: 29 Page(s): 440 - 448
08/01/2023 Authors: Fu R; Jinnah H; Mckay JL; Miller AH; Felger JC; Farber EW; Sharma S; Whicker N; Moore RC; Franklin D
Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer.
Head Neck Volume: 45 Page(s): 1952 - 1966
08/01/2023 Authors: Huang S; Zhan Y; Jeon S; Bruner DW; Miller AH; Felger JC; Wommack EC; Saba NF; Higgins KA; Irwin ML
Omega-3 Fatty Acids for Depression: Recent Finding
Volume: 79 Page(s): 280 - 280
08/01/2023 Authors: Mischoulon D; Dunlop BW; Kinkead B; Schettler PJ; Lamon-Fava S; So J; Maddipati KR; Felger JC; Fava M; Rapaport MH
Associations of inflammation with neuropsychological symptom cluster in patients with Head and neck cancer: A longitudinal study.
Brain Behav Immun Health Volume: 30 Page(s): 100649
07/01/2023 Authors: Amirkhanzadeh Barandouzi Z; Bruner DW; Miller AH; Paul S; Felger JC; Wommack EC; Higgins KA; Shin DM; Saba NF; Xiao C
Clinical response to EPA supplementation in patients with major depressive disorder is associated with higher plasma concentrations of pro-resolving lipid mediators.
Neuropsychopharmacology Volume: 48 Page(s): 929 - 935
05/01/2023 Authors: Lamon-Fava S; Liu M; Dunlop BW; Kinkead B; Schettler PJ; Felger JC; Ziegler TR; Fava M; Mischoulon D; Rapaport MH
Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology.
Biol Psychiatry Volume: 93 Page(s): 405 - 418
03/01/2023 Authors: Goldsmith DR; Bekhbat M; Mehta ND; Felger JC
Increased Inflammation and Treatment of Depression: From Resistance to Reuse, Repurposing, and Redesign.
Adv Neurobiol Volume: 30 Page(s): 387 - 416
01/01/2023 Authors: Felger JC
Immunometabolic Gene Pathways are Associated With Anhedonia and Altered Following a TNF-Alpha Antagonist in Patients With Depression and High Inflammation
Volume: 47 Page(s): 232 - 232
12/01/2022 Authors: Bekhbat M; Haroon E; Etuk S; Felger J; Miller A; Treadway M
From Blue to Gray: Inflammation, Aging and Neurodegeneration in Depression
Volume: 47 Page(s): 246 - 247
12/01/2022 Authors: Haroon E; Beltran D; Chen X; Wommack E; Roberts B; Qiu D; Goldstein F; Treadway M; Felger J; Miller A
Connecting the dots from east to west.
Brain Behav Immun Health Volume: 26 Page(s): 100569
12/01/2022 Authors: Kelley KW; Felger J; Bekhbat M
Inflammation, amygdala-ventromedial prefrontal functional connectivity and symptoms of anxiety and PTSD in African American women recruited from an inner-city hospital: Preliminary results.
Brain Behav Immun Volume: 105 Page(s): 122 - 130
10/01/2022 Authors: Mehta ND; Stevens JS; Li Z; Fani N; Gillespie CF; Ravi M; Michopoulos V; Felger JC
Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study.
Mol Psychiatry Volume: 27 Page(s): 4113 - 4121
10/01/2022 Authors: Bekhbat M; Li Z; Mehta ND; Treadway MT; Lucido MJ; Woolwine BJ; Haroon E; Miller AH; Felger JC
Correction to: Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study.
Mol Psychiatry Volume: 27 Page(s): 4122
10/01/2022 Authors: Bekhbat M; Li Z; Mehta ND; Treadway MT; Lucido MJ; Woolwine BJ; Haroon E; Miller AH; Felger JC
Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Randomized Dose-Finding Clinical Trial.
J Clin Psychiatry Volume: 83
08/22/2022 Authors: Mischoulon D; Dunlop BW; Kinkead B; Schettler PJ; Lamon-Fava S; Rakofsky JJ; Nierenberg AA; Clain AJ; Mletzko Crowe T; Wong A
The role of the immune system in posttraumatic stress disorder.
Transl Psychiatry Volume: 12 Page(s): 313
08/04/2022 Authors: Katrinli S; Oliveira NCS; Felger JC; Michopoulos V; Smith AK
Cellular and immunometabolic mechanisms of inflammation in depression: Preliminary findings from single cell RNA sequencing and a tribute to Bruce McEwen.
Neurobiol Stress Volume: 19 Page(s): 100462
07/01/2022 Authors: Bekhbat M; Ulukaya GB; Bhasin MK; Felger JC; Miller AH
Longitudinal Association of Physical Activity and Inflammatory Markers With Quality of Life in Head and Neck Cancer Patients
Volume: 71 Page(s): S27 - S28
05/01/2022 Authors: Huang S; Jeon S; Bruner D; Miller A; Felger J; Wommack E; Saba N; Higgins K; Xiao C
Inflammation as a Pathophysiologic Pathway to Anhedonia: Mechanisms and Therapeutic Implications.
Curr Top Behav Neurosci Volume: 58 Page(s): 397 - 419
01/01/2022 Authors: Bekhbat M; Treadway MT; Felger JC
Influences of dopaminergic system dysfunction on late-life depression.
Mol Psychiatry Volume: 27 Page(s): 180 - 191
01/01/2022 Authors: Taylor WD; Zald DH; Felger JC; Christman S; Claassen DO; Horga G; Miller JM; Gifford K; Rogers B; Szymkowicz SM
Reward Circuits and Symptoms of Anhedonia as Modifiable Targets for Therapy in Depressed Patients With High inflammation: Evidence From a Dopaminergic Challenge Study
Volume: 46 Page(s): 60 - 61
12/01/2021 Authors: Felger J
Increased Effort Expenditure in Major Depression Following a TNF-Alpha Antagonist is Mediated by Change in Systemic Immunometabolism
Volume: 46 Page(s): 239 - 239
12/01/2021 Authors: Etuk S; Hahn E; DeVries B; Cooper J; Irfan N; Harrison D; Nuutinen M; Lal A; Arulpragasam A; Hossein S
Childhood Trauma Moderates the Relationship Between Inflammation and Functional Connectivity Between the Amygdala and Ventromedial Prefrontal Cortex in Association with Anxiety in Trauma-Exposed Women
Volume: 46 Page(s): 104 - 105
12/01/2021 Authors: Mehta N; Stevens J; Li Z; Fani N; Gillespie C; Michopoulos V; Felger J
Transcriptomic signatures of psychomotor slowing in peripheral blood of depressed patients: evidence for immunometabolic reprogramming.
Mol Psychiatry Volume: 26 Page(s): 7384 - 7392
12/01/2021 Authors: Bekhbat M; Goldsmith DR; Woolwine BJ; Haroon E; Miller AH; Felger JC
SNP's association with fatigue and physical activity in head and neck cancer patients: a pilot study for inflammatory mechanisms
Volume: 30 Page(s): S147 - S147
10/01/2021 Authors: Xiao C; Ye Y; Miller A; Higgins K; Saba N; Zhao H; Gary R; Withycombee J; Wommack E; Felger J
Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study.
Cancer Volume: 127 Page(s): 3361 - 3371
09/15/2021 Authors: Xiao C; Beitler JJ; Peng G; Levine ME; Conneely KN; Zhao H; Felger JC; Wommack EC; Chico CE; Jeon S
Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression.
Transl Psychiatry Volume: 11 Page(s): 456
09/04/2021 Authors: Chen X; Beltran DJ; Tsygankova VD; Woolwine BJ; Patel T; Baer W; Felger JC; Miller AH; Haroon E
Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications.
Pharmacol Rev Volume: 73 Page(s): 1084 - 1117
07/01/2021 Authors: Lucido MJ; Bekhbat M; Goldsmith DR; Treadway MT; Haroon E; Felger JC; Miller AH
Transcriptomic Signatures of Inflammation and Metabolic Reprogramming in Peripheral Blood Immune Cells are Implicated in Psychomotor Retardation in Depression
Volume: 89 Page(s): S377 - S378
05/01/2021 Authors: Bekhbat M; Goldsmith DR; Woolwine BJ; Haroon E; Miller AH; Felger JC
Remembering Bruce S. McEwen - A tribute from psychoneuroimmunology.
Brain Behav Immun Volume: 94 Page(s): 11 - 14
05/01/2021 Authors: Dhabhar FS; Danese A; Felger JC; Miller AH
Special Issue: The intersection of inflammation and metabolism in neuropsychiatric disorders.
Brain Behav Immun Volume: 93 Page(s): 331 - 334
03/01/2021 Authors: Felger JC; Capuron L
Dose- and time-dependent increase in circulating anti-inflammatory and pro-resolving lipid mediators following eicosapentaenoic acid supplementation in patients with major depressive disorder and chronic inflammation.
Prostaglandins Leukot Essent Fatty Acids Volume: 164 Page(s): 102219
01/01/2021 Authors: Lamon-Fava S; So J; Mischoulon D; Ziegler TR; Dunlop BW; Kinkead B; Schettler PJ; Nierenberg AA; Felger JC; Maddipati KR
Metabolic Dysfunction and Inflammation Together Associate With Functional Connectivity in Reward Circuitry in Depression: Role of PTSD and Childhood Trauma in Women
Volume: 45 Page(s): 26 - 27
12/01/2020 Authors: Felger J
Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women.
Soc Cogn Affect Neurosci Volume: 15 Page(s): 1046 - 1055
11/10/2020 Authors: Mehta ND; Stevens JS; Li Z; Gillespie CF; Fani N; Michopoulos V; Felger JC
Depression-free after Interferon- exposure indicates less incidence of depressive disorder: A longitudinal study in Taiwan.
Brain Behav Immun Volume: 88 Page(s): 125 - 131
08/01/2020 Authors: Sun C-F; Chiu W-C; Chen P-C; Chang H-C; Guu T-W; Shityakov S; Miller AH; Felger JC; Chang JP-C; Su K-P
Protein and gene markers of metabolic dysfunction and inflammation together associate with functional connectivity in reward and motor circuits in depression.
Brain Behav Immun Volume: 88 Page(s): 193 - 202
08/01/2020 Authors: Goldsmith DR; Bekhbat M; Le N-A; Chen X; Woolwine BJ; Li Z; Haroon E; Felger JC
Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia.
Brain Behav Immun Volume: 88 Page(s): 161 - 165
08/01/2020 Authors: Bekhbat M; Treadway MT; Goldsmith DR; Woolwine BJ; Haroon E; Miller AH; Felger JC
Identifying Immunophenotypes of Inflammation in Depression: Dismantling the Monolith.
Biol Psychiatry Volume: 88 Page(s): 136 - 138
07/15/2020 Authors: Felger JC; Miller AH
GENE SIGNATURES RELATED TO INSULIN SIGNALING AND TYROSINE METABOLISM DEFINE A SUB-TYPE OF DEPRESSION WITH ANHEDONIA AND HIGH CRP
Volume: 82 Page(s): A197 - A197
07/01/2020 Authors: Bekhbat M; Goldsmith DR; Treadway MT; Woolwine BJ; Haroon E; Miller AH; Felger JC
Association Among Glucocorticoid Receptor Sensitivity, Fatigue, and Inflammation in Patients With Head and Neck Cancer.
Psychosom Med Volume: 82 Page(s): 508 - 516
06/01/2020 Authors: Xiao C; Eldridge RC; Beitler JJ; Higgins KA; Chico CE; Felger JC; Wommack EC; Knobf T; Saba NF; Shin DM
What does plasma CRP tell us about peripheral and central inflammation in depression?
Mol Psychiatry Volume: 25 Page(s): 1301 - 1311
06/01/2020 Authors: Felger JC; Haroon E; Patel TA; Goldsmith DR; Wommack EC; Woolwine BJ; Le N-A; Feinberg R; Tansey MG; Miller AH
Does n-3 Fatty Acid Supplementation Impact Immune and Clinical Outcomes in Inflammatory Depression?
Volume: 87 Page(s): S40 - S40
05/01/2020 Authors: Rapaport M; Mischoulon D; Fava M; Dunlop B; Kinkead B; Felger J; Nierenberg A; Schettler P; Lamon-Fava S
Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression.
Neuropsychopharmacology Volume: 45 Page(s): 998 - 1007
05/01/2020 Authors: Haroon E; Welle JR; Woolwine BJ; Goldsmith DR; Baer W; Patel T; Felger JC; Miller AH
Inflammatory markers are associated with psychomotor slowing in patients with schizophrenia compared to healthy controls.
NPJ Schizophr Volume: 6 Page(s): 8
04/01/2020 Authors: Goldsmith DR; Massa N; Pearce BD; Wommack EC; Alrohaibani A; Goel N; Cuthbert B; Fargotstein M; Felger JC; Haroon E
Reward-related brain activity and behavior are associated with peripheral ghrelin levels in obesity.
Psychoneuroendocrinology Volume: 112 Page(s): 104520
02/01/2020 Authors: Bogdanov VB; Bogdanova OV; Dexpert S; Delgado I; Beyer H; Aubert A; Dilharreguy B; Beau C; Forestier D; Ledaguenel P
Omega-3 fatty acids for major depressive disorder with high inflammation: A personalized approach
Volume: 29 Page(s): S250 - S251
12/01/2019 Authors: Mischoulon D; Dunlop B; Kinkead B; Schettler P; Lamon-Fava S; Nierenberg A; Felger J; Clain A; Mletzko T; Wong A
Severity of Psychomotor Retardation in Depression is Associated With mRNA Enrichment of Inflammatory and Metabolic Signaling Pathways
Volume: 44 Page(s): 438 - 439
12/01/2019 Authors: Goldsmith D; Bekhbat M; Woolwine B; Haroon E; Miller A; Felger J
Quinolinic Acid is Associated With Increased Basal Ganglia Glutamate and Anhedonia in Patients With Major Depression
Volume: 44 Page(s): 148 - 148
12/01/2019 Authors: Haroon E; Chen X; Baer W; Churillo K; Lis C; Woolwine B; Patel T; Felger J; Miller A
Latent class analysis of fatigue and its association with quality of life and inflammation in patients with head and neck cancer who have undergone definitive radiation
Volume: 28 Page(s): S52 - S53
10/01/2019 Authors: Xiao C; Eldridge R; Beitler J; Higgins K; Chico C; Withycombe J; Wommack E; Felger J; Knobf T; Miller A
High inflammation is associated with low functional connectivity in reward circuitry and symptoms of anhedonia and PTSD in a high-trauma population
Volume: 81 Page(s): 33 - 33
10/01/2019 Authors: Mehta ND; Michopoulos V; Stevens JS; Miller AH; Li Z; Felger JC
Severity of psychomotor retardation in depressed patients is associated with mRNA enrichment of toll-like receptor, cytokine and mTOR signaling pathways
Volume: 81 Page(s): 29 - 29
10/01/2019 Authors: Bekhbat M; Goldsmith DR; Miller AH; Felger JC
Inflammation and decreased functional connectivity in a widely-distributed network in depression: Centralized effects in the ventral medial prefrontal cortex.
Brain Behav Immun Volume: 80 Page(s): 657 - 666
08/01/2019 Authors: Yin L; Xu X; Chen G; Mehta ND; Haroon E; Miller AH; Luo Y; Li Z; Felger JC
Inflammation Effects on Striatal Dopamine: Implications for Late Life Depression
Volume: 85 Page(s): S42 - S43
05/15/2019 Authors: Felger J; Haroon E; Miller A; Li Z
'Inflammaging' in Depression - Morphological, Metabolic and Behavioral Consequences
Volume: 85 Page(s): S93 - S94
05/15/2019 Authors: Haroon E; Chen X; Kim AH; Woolwine B; Patel T; Felger JC; Miller A
FromInflammation to Anhedonia - Role of Glutamate, Regional Homogeneity and Network Dysfunction
Volume: 85 Page(s): S59 - S59
05/15/2019 Authors: Haroon E; Chen X; Kim AH; Woolwine B; Patel T; Li Z; Felger J; Miller A
INFLAMMATION, DOPAMINERGIC DECLINE, AND PSYCHOMOTOR SLOWING AS PATHOLOGIC ROUTES TO LATE LIFE DEPRESSION
Volume: 27 Page(s): S32 - S33
03/01/2019 Authors: Diniz BS; Rutherford BR; Aizenstein H; Felger JC
Role of Inflammation in Depression and Treatment Implications.
Handb Exp Pharmacol Volume: 250 Page(s): 255 - 286
01/01/2019 Authors: Felger JC
Inflammation-Related Disruptions in Corticostriatal and Amygdala-Prefrontal Circuits in Depression: Associations With Anhedonia, Anxiety and Response to Dopaminergic Therapy
Volume: 43 Page(s): S45 - S45
12/01/2018 Authors: Felger J
'Inflammaging' Selectively Disrupts Structural and Functional Integrity of Subcortical Brain Structures to Precipitate Cognitive Impairments in Depression
Volume: 43 Page(s): S300 - S301
12/01/2018 Authors: Haroon E; Chen X; Patel T; Woolwine B; Hu X; Felger J; Miller A
Glucose and lipid-related biomarkers and the antidepressant response to infliximab in patients with treatment-resistant depression.
Psychoneuroendocrinology Volume: 98 Page(s): 222 - 229
12/01/2018 Authors: Bekhbat M; Chu K; Le N-A; Woolwine BJ; Haroon E; Miller AH; Felger JC
What's CRP got to do with it? Tackling the complexities of the relationship between CRP and depression.
Brain Behav Immun Volume: 73 Page(s): 163 - 164
10/01/2018 Authors: Felger JC; Haroon E; Miller AH
Inflammation negatively correlates with amygdala-ventromedial prefrontal functional connectivity in association with anxiety in patients with depression: Preliminary results.
Brain Behav Immun Volume: 73 Page(s): 725 - 730
10/01/2018 Authors: Mehta ND; Haroon E; Xu X; Woolwine BJ; Li Z; Felger JC
HIV and symptoms of depression are independently associated with impaired glucocorticoid signaling.
Psychoneuroendocrinology Volume: 96 Page(s): 118 - 125
10/01/2018 Authors: Bekhbat M; Mehta CC; Kelly SD; Vester A; Ofotokun I; Felger J; Wingood G; Anastos K; Gustafson DR; Kassaye S
Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia.
Transl Psychiatry Volume: 8 Page(s): 189
09/10/2018 Authors: Haroon E; Chen X; Li Z; Patel T; Woolwine BJ; Hu XP; Felger JC; Miller AH
Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder.
Psychoneuroendocrinology Volume: 95 Page(s): 43 - 49
09/01/2018 Authors: Haroon E; Daguanno AW; Woolwine BJ; Goldsmith DR; Baer WM; Wommack EC; Felger JC; Miller AH
Associations among human papillomavirus, inflammation, and fatigue in patients with head and neck cancer.
Cancer Volume: 124 Page(s): 3163 - 3170
08/01/2018 Authors: Xiao C; Beitler JJ; Higgins KA; Glazer T; Huynh LK; Paul S; Felger JC; Wommack EC; Saba NF; Shin DM
Inflammation Effects on Motivation and Motor Activity: Dopamine as Mediator and Treatment Target
Volume: 83 Page(s): S62 - S63
05/01/2018 Authors: Miller A; Haroon E; Felger J
NEW PERSPECTIVES ON FATIGUE: CLINICAL, EXPERIMENTAL, AND NEUROIMAGING APPROACHES TO UNDERSTANDING CANCER-RELATED FATIGUE
Volume: 80 Page(s): A144 - A144
04/01/2018 Authors: Bower J; Dantzer R; Felger J; Dimsdale J
Inflammation-associated Alterations in Corticostriatal Circuit Function in Breast Cancer: Relationship with Motivational and Motor Deficits and Fatigue
Volume: 80 Page(s): A145 - A146
04/01/2018 Authors: Felger J; Treadway MT; Li Z; Haroon E; Torres MA; Miller AH
Imaging the Role of Inflammation in Mood and Anxiety-related Disorders.
Curr Neuropharmacol Volume: 16 Page(s): 533 - 558
01/01/2018 Authors: Felger JC
Depressive symptoms and inflammation are independent risk factors of fatigue in breast cancer survivors.
Psychol Med Volume: 47 Page(s): 1733 - 1743
07/01/2017 Authors: Xiao C; Miller AH; Felger J; Mister D; Liu T; Torres MA
ASSOCIATION BETWEEN INFLAMMATORY MARKERS AND NEGATIVE SYMPTOMS IN INDIVIDUALS WITH PERSISTENT SYMPTOMS OF SCHIZOPHRENIA TREATED WITH CLOZAPINE
SCHIZOPHRENIA BULLETIN Volume: 43 Page(s): S184 - S184
03/01/2017 Authors: Goldsmith D; Kopelovich S; Novacek D; Widener J; Wommack E; Felger J; Miller A; Cotes R
The Immunology of Behavior-Exploring the Role of the Immune System in Brain Health and Illness.
Neuropsychopharmacology Volume: 42 Page(s): 1 - 4
01/01/2017 Authors: Miller AH; Haroon E; Felger JC
Therapeutic Implications of Brain-Immune Interactions: Treatment in Translation.
Neuropsychopharmacology Volume: 42 Page(s): 334 - 359
01/01/2017 Authors: Miller AH; Haroon E; Felger JC
Inflammation Effects on Motivation and Motor Activity: Role of Dopamine.
Neuropsychopharmacology Volume: 42 Page(s): 216 - 241
01/01/2017 Authors: Felger JC; Treadway MT
The Role of Dopamine in Inflammation-Associated Depression: Mechanisms and Therapeutic Implications.
Curr Top Behav Neurosci Volume: 31 Page(s): 199 - 219
01/01/2017 Authors: Felger JC
Association Between Inflammatory Markers and Negative Symptoms in Individuals With Persistent Symptoms of Schizophrenia Treated With Clozapine
NEUROPSYCHOPHARMACOLOGY Volume: 41 Page(s): S390 - S391
12/01/2016 Authors: Goldsmith D; Kopelovich S; Novacek D; Widener J; Wommack E; Felger J; Miller A; Cotes R
CNS Immune Activation and Effects on Mesolimbic Dopamine in a Non-Human Primate Model of Peripheral Cytokine-Induced Depression
Volume: 41 Page(s): S57 - S57
12/01/2016 Authors: Felger J
Editorial introduction: The effects of somatic disease and environmental insults on the stress response.
Physiol Behav Volume: 166 Page(s): 1 - 3
11/01/2016 Authors: Neigh GN; Felger JC
Interferon-alpha-induced inflammation is associated with reduced glucocorticoid negative feedback sensitivity and depression in patients with hepatitis C virus.
Physiol Behav Volume: 166 Page(s): 14 - 21
11/01/2016 Authors: Felger JC; Haroon E; Woolwine BJ; Raison CL; Miller AH
Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression.
Mol Psychiatry Volume: 21 Page(s): 1351 - 1357
10/01/2016 Authors: Haroon E; Fleischer CC; Felger JC; Chen X; Woolwine BJ; Patel T; Hu XP; Miller AH
Depression and inflammation are independent predictors of fatigue in breast cancer survivors
Volume: 57 Page(s): E6 - E6
10/01/2016 Authors: Xiao C; Miller A; Felger J; Mister D; Liu T; Torres M
Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression.
Mol Psychiatry Volume: 21 Page(s): 1358 - 1365
10/01/2016 Authors: Felger JC; Li Z; Haroon E; Woolwine BJ; Jung MY; Hu X; Miller AH
Inflammatory markers are associated with decreased psychomotor speed in patients with major depressive disorder.
Brain Behav Immun Volume: 56 Page(s): 281 - 288
08/01/2016 Authors: Goldsmith DR; Haroon E; Woolwine BJ; Jung MY; Wommack EC; Harvey PD; Treadway MT; Felger JC; Miller AH
Inflammation Effects on Reward Circuitry and Anhedonia
Volume: 79 Page(s): 286S - 286S
05/01/2016 Authors: Felger JC
Inflammatory Markers are Associated with Decreased Psychomotor Speed in Patients with Major Depressive Disorder
Volume: 79 Page(s): 53S - 53S
05/01/2016 Authors: Goldsmith DR; Haroon E; Woolwine BJ; Jung MY; Wommack E; Harvey PD; Treadway MT; Felger JC; Miller AH
Association of childhood trauma with fatigue, depression, stress, and inflammation in breast cancer patients undergoing radiotherapy.
Psychooncology Volume: 25 Page(s): 187 - 193
02/01/2016 Authors: Han TJ; Felger JC; Lee A; Mister D; Miller AH; Torres MA
Fatigue is associated with inflammation in patients with head and neck cancer before and after intensity-modulated radiation therapy.
Brain Behav Immun Volume: 52 Page(s): 145 - 152
02/01/2016 Authors: Xiao C; Beitler JJ; Higgins KA; Conneely K; Dwivedi B; Felger J; Wommack EC; Shin DM; Saba NF; Ong LY
A prospective study of quality of life in breast cancer patients undergoing radiation therapy.
Adv Radiat Oncol Volume: 1 Page(s): 10 - 16
01/01/2016 Authors: Xiao C; Miller AH; Felger J; Mister D; Liu T; Torres MA
Inflammation-Related Decreases in Dopamine and Effects on Corticostriatal Reward Circuitry: Evidence from Humans and Non-Human Primates
Volume: 40 Page(s): S37 - S37
12/01/2015 Authors: Felger J
Inflammatory Cytokines Are Associated with Decreased Psychomotor Speed in Female, but Not Male, Patients with Major Depression
Volume: 40 Page(s): S339 - S340
12/01/2015 Authors: Goldsmith D; Haroon E; Woolwine B; Jung M; Wommack E; Felger J; Miller A
Conceptual Convergence: Increased Inflammation is Associated with Increased Basal Ganglia Glutamate in Patients with Major Depression
Volume: 40 Page(s): S335 - S336
12/01/2015 Authors: Haroon E; Fleischer C; Chen X; Felger J; Woolwine B; Hu X; Miller A
Inhibition of tumor necrosis factor improves sleep continuity in patients with treatment resistant depression and high inflammation.
Brain Behav Immun Volume: 47 Page(s): 193 - 200
07/01/2015 Authors: Weinberger JF; Raison CL; Rye DB; Montague AR; Woolwine BJ; Felger JC; Haroon E; Miller AH
Risk and Resilience: Animal Models Shed Light on the Pivotal Role of Inflammation in Individual Differences in Stress-Induced Depression.
Biol Psychiatry Volume: 78 Page(s): 7 - 9
07/01/2015 Authors: Felger JC; Haroon E; Miller AH
Age-related increases in basal ganglia glutamate are associated with TNF, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: Preliminary findings.
Brain Behav Immun Volume: 46 Page(s): 17 - 22
05/01/2015 Authors: Haroon E; Felger JC; Woolwine BJ; Chen X; Parekh S; Spivey JR; Hu XP; Miller AH
Inflammatory cytokine effects on neurotransmitters, neurocircuits, and behavior in depression
JOURNAL OF NEUROIMMUNE PHARMACOLOGY Volume: 10 Page(s): S69 - S69
04/01/2015 Authors: Felger JC; Haroon E; Woolwine BJ; Miller AH
Levodopa reverses cytokine-induced reductions in striatal dopamine release.
Int J Neuropsychopharmacol Volume: 18
01/31/2015 Authors: Felger JC; Hernandez CR; Miller AH
Levodopa Reverses Cytokine-induced Reductions in Striatal Dopamine Release
Volume: 39 Page(s): S617 - S618
12/01/2014 Authors: Felger J; Hernandez C; Miller A
Interaction of Aging and Inflammation is Associated with Increased Basal Ganglia Glutamate and Reduced Motivation and Motor Activity During Inteferon-Alpha Therapy
Volume: 39 Page(s): S204 - S204
12/01/2014 Authors: Haroon E; Felger JC; Woolwine BJ; Jung MY; Patel JD; Chen X; Hu XP; Miller AH
Increased Fatigue Is Associated With TNF and NF kappa B-Regulated Inflammatory Signaling in Patients With Head and Neck Cancer Receiving IMRT
Volume: 90 Page(s): S571 - S571
09/01/2014 Authors: Xiao C; Beitler JJ; Higgins KA; Felger J; Ong LY; Shin DM; Saba NF; Bruner DW; Miller AH
The Neurocircuitry of Inflammation in Depression
Volume: 75 Page(s): 400S - 400S
05/01/2014 Authors: Felger JC; Li Z; Haroon E; Brigitta G; Hu X; Miller A
Epigenetic changes associated with inflammation in breast cancer patients treated with chemotherapy.
Brain Behav Immun Volume: 38 Page(s): 227 - 236
05/01/2014 Authors: Smith AK; Conneely KN; Pace TWW; Mister D; Felger JC; Kilaru V; Akel MJ; Vertino PM; Miller AH; Torres MA
FRAILTY AND DEPRESSION IN LATE LIFE: PHENOMENOLOGY, PROGNOSIS, AND PATHOPHYSIOLOGY
Volume: 22 Page(s): S16 - S16
03/01/2014 Authors: Brown PJ; Mezuk B; Felger J; Roose S
The immune response to stress in orchestra musicians: setting the stage for naturalistic paradigms.
Brain Behav Immun Volume: 37 Page(s): 21 - 22
03/01/2014 Authors: Felger JC
Neurotherapeutic implications of brain-immune interactions.
Neuropsychopharmacology Volume: 39 Page(s): 242 - 243
01/01/2014 Authors: Felger JC; Miller AH
Chronic interferon- decreases dopamine 2 receptor binding and striatal dopamine release in association with anhedonia-like behavior in nonhuman primates.
Neuropsychopharmacology Volume: 38 Page(s): 2179 - 2187
10/01/2013 Authors: Felger JC; Mun J; Kimmel HL; Nye JA; Drake DF; Hernandez CR; Freeman AA; Rye DB; Goodman MM; Howell LL
A prospective study on behavioral symptoms' impact to the quality of life in patients with early-stage cancer receiving radiotherapy.
J Clin Oncol Volume: 31 Page(s): 46
09/10/2013 Authors: Felger J; Mister D; Liu T; Miller AH; Torres MA
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.
Neuroscience Volume: 246 Page(s): 199 - 229
08/29/2013 Authors: Felger JC; Lotrich FE
Tyrosine metabolism during interferon-alpha administration: association with fatigue and CSF dopamine concentrations.
Brain Behav Immun Volume: 31 Page(s): 153 - 160
07/01/2013 Authors: Felger JC; Li L; Marvar PJ; Woolwine BJ; Harrison DG; Raison CL; Miller AH
Transcriptional signatures related to glucose and lipid metabolism predict treatment response to the tumor necrosis factor antagonist infliximab in patients with treatment-resistant depression.
Brain Behav Immun Volume: 31 Page(s): 205 - 215
07/01/2013 Authors: Mehta D; Raison CL; Woolwine BJ; Haroon E; Binder EB; Miller AH; Felger JC
Predictors of depression in breast cancer patients treated with radiation: role of prior chemotherapy and nuclear factor kappa B.
Cancer Volume: 119 Page(s): 1951 - 1959
06/01/2013 Authors: Torres MA; Pace TW; Liu T; Felger JC; Mister D; Doho GH; Kohn JN; Barsevick AM; Long Q; Miller AH
Cytokine targets in the brain: impact on neurotransmitters and neurocircuits.
Depress Anxiety Volume: 30 Page(s): 297 - 306
04/01/2013 Authors: Miller AH; Haroon E; Raison CL; Felger JC
Prospective Longitudinal Study of Radiation-induced Cutaneous Toxicity in Breast Cancer Patients Undergoing Breast Conserving Therapy
Volume: 84 Page(s): S189 - S190
11/01/2012 Authors: Torres M; Yang X; Pace T; Felger J; Godette KD; Stapleford L; Mister D; Kohn J; Miller A; Liu T
Molecular signatures of peripheral blood mononuclear cells during chronic interferon- treatment: relationship with depression and fatigue.
Psychol Med Volume: 42 Page(s): 1591 - 1603
08/01/2012 Authors: Felger JC; Cole SW; Pace TWW; Hu F; Woolwine BJ; Doho GH; Raison CL; Miller AH
Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise.
Front Neuroendocrinol Volume: 33 Page(s): 315 - 327
08/01/2012 Authors: Felger JC; Miller AH
A prospective longitudinal study of cancer-related fatigue in patients undergoing breast-conserving surgery and radiation with or without chemotherapy for breast cancer
Volume: 30
05/20/2012 Authors: Torres MA; Pace T; Felger J; Liu T; Godette KD; Stapleford LJ; Mister D; Miller AH
Changes in Tyrosine Metabolism are Associated with Fatigue in Interferon-Alpha-Treated Patients
Volume: 71 Page(s): 304S - 305S
04/15/2012 Authors: Felger JC; Woolwine BJ; Raison CL; Miller AH
Accumulation of resident and peripheral dendritic cells in the aging CNS.
Neurobiol Aging Volume: 33 Page(s): 681 - 693.e1
04/01/2012 Authors: Kaunzner UW; Miller MM; Gottfried-Blackmore A; Gal-Toth J; Felger JC; McEwen BS; Bulloch K
Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue.
Brain Behav Immun Volume: 25 Page(s): 1094 - 1098
08/01/2011 Authors: Felger JC; Alagbe O; Pace TWW; Woolwine BJ; Hu F; Raison CL; Miller AH
Brain dendritic cells in ischemic stroke: time course, activation state, and origin.
Brain Behav Immun Volume: 24 Page(s): 724 - 737
07/01/2010 Authors: Felger JC; Abe T; Kaunzner UW; Gottfried-Blackmore A; Gal-Toth J; McEwen BS; Iadecola C; Bulloch K
Acute in vivo exposure to interferon-gamma enables resident brain dendritic cells to become effective antigen presenting cells.
Proc Natl Acad Sci U S A Volume: 106 Page(s): 20918 - 20923
12/08/2009 Authors: Gottfried-Blackmore A; Kaunzner UW; Idoyaga J; Felger JC; McEwen BS; Bulloch K
Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression.
Biol Psychiatry Volume: 62 Page(s): 1324 - 1333
12/01/2007 Authors: Felger JC; Alagbe O; Hu F; Mook D; Freeman AA; Sanchez MM; Kalin NH; Ratti E; Nemeroff CB; Miller AH
Activated p38 MAPK is associated with decreased CSF 5-HIAA and increased maternal rejection during infancy in rhesus monkeys.
Mol Psychiatry Volume: 12 Page(s): 895 - 897
10/01/2007 Authors: Sanchez MM; Alagbe O; Felger JC; Zhang J; Graff AE; Grand AP; Maestripieri D; Miller AH
Tamoxifen fails to affect central serotonergic tone but increases indices of anxiety in female rhesus macaques.
Psychoneuroendocrinology Volume: 30 Page(s): 273 - 283
04/01/2005 Authors: Mook D; Felger J; Graves F; Wallen K; Wilson ME
Nociceptin/orphanin FQ increases anxiety-related behavior and circulating levels of corticosterone during neophobic tests of anxiety.
Neuropsychopharmacology Volume: 29 Page(s): 59 - 71
01/01/2004 Authors: Fernandez F; Misilmeri MA; Felger JC; Devine DP
Tamoxifen is an estrogen antagonist on gonadotropin secretion and responsiveness of the hypothalamic-pituitary- adrenal axis in female monkeys.
Endocrine Volume: 22 Page(s): 305 - 315
12/01/2003 Authors: Wilson ME; Mook D; Graves F; Felger J; Bielsky IF; Wallen K

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Jennifer Felger PhD

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