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Profile

James Dahlman

  • Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory
    Associate Professor
  • james.dahlman@emory.edu

Research

Publications

  • Lipid nanoparticle screening in nonhuman primates with minimal loss of life.
    Nat Biotechnol
    06/26/2025 Authors: Zenhausern R; Jang B; Schrader Echeverri E; Gentry K; Calkins R; Curran EH; Wood JS; Stammen RL; Loughrey D; Chappa P
  • In utero lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells.
    bioRxiv
    05/12/2025 Authors: Worthington AK; Borges B; Lum T; Echeverri ES; Zada FM; Cordero MA; Kim H; Zenhausern R; Celik O; Shaw C
  • Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses.
    Nat Commun Volume: 16 Page(s): 3490
    04/12/2025 Authors: Huayamares SG; Lian L; Rab R; Hou Y; Radmand A; Kim H; Zenhausern R; Achyut BR; Gilbert Ross M; Lokugamage MP
  • The time course of in vivo cellular responses to LNPs.
    Chem Commun (Camb) Volume: 61 Page(s): 4535 - 4538
    03/13/2025 Authors: Loughrey D; Paunovska K; Echeverri ES; Tiegreen KE; Dahlman JE
  • Amelioration of a von Willebrand disease type 2B phenotype invivo upon treatment with allele-selective siRNAs.
    Blood Adv Volume: 9 Page(s): 310 - 320
    01/28/2025 Authors: Linthorst NA; Jongejan YK; Dirven RJ; Laan SNJ; Bierings R; Casari C; Cordfunke RA; Dahlman JE; Dolezal N; Drijfhout JW
  • Silencing of the von Willebrand factor gene in proatherothrombotic APOE3-Leiden.CETP transgenic mice.
    Res Pract Thromb Haemost Volume: 9 Page(s): 102699
    01/01/2025 Authors: Jongejan YK; Dirven RJ; Schrader Echeverri E; de Jong AJL; Pronk ACM; Kooijman S; Rensen PCN; Dahlman JE; Eikenboom JCJ; van Vlijmen BJM
  • Lipid nanoparticle-mediated mRNA delivery to CD34+ cells in rhesus monkeys.
    Nat Biotechnol
    11/22/2024 Authors: Kim H; Zenhausern R; Gentry K; Lian L; Huayamares SG; Radmand A; Loughrey D; Podilapu AR; Hatit MZC; Ni H
  • Lymphatic endothelial cell-targeting lipid nanoparticles delivering VEGFC mRNA improve lymphatic function after injury.
    bioRxiv
    07/31/2024 Authors: Michalaki E; Chin R; Jeong K; Qi Z; Liebman LN; Gonzlez-Vargas Y; Echeverri ES; Paunovska K; Muramatsu H; Pardi N
  • Substituting Poly(ethylene glycol) Lipids with Poly(2-ethyl-2-oxazoline) Lipids Improves Lipid Nanoparticle Repeat Dosing.
    Adv Healthc Mater Volume: 13 Page(s): e2304033
    07/01/2024 Authors: Sanchez AJDS; Loughrey D; Echeverri ES; Huayamares SG; Radmand A; Paunovska K; Hatit M; Tiegreen KE; Santangelo PJ; Dahlman JE
  • Nucleic acid-based drugs for patients with solid tumours.
    Nat Rev Clin Oncol Volume: 21 Page(s): 407 - 427
    06/01/2024 Authors: Huayamares SG; Loughrey D; Kim H; Dahlman JE; Sorscher EJ
  • Impact of allele-selective silencing of von Willebrand factor in mice based on a single nucleotide allelic difference in von Willebrand factor.
    Thromb Res Volume: 236 Page(s): 201 - 208
    04/01/2024 Authors: Jongejan YK; Linthorst NA; Schrader Echeverri E; Laan SNJ; Dirven RJ; Dahlman JE; van Vlijmen BJM; Denis CV; Eikenboom JCJ
  • RNA delivery systems.
    Proc Natl Acad Sci U S A Volume: 121 Page(s): e2315789121
    03/12/2024 Authors: Bhatia SN; Dahlman JE
  • Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart.
    Proc Natl Acad Sci U S A Volume: 121 Page(s): e2307801120
    03/12/2024 Authors: Radmand A; Kim H; Beyersdorf J; Dobrowolski CN; Zenhausern R; Paunovska K; Huayamares SG; Hua X; Han K; Loughrey D
  • Light-field flow cytometry for high-resolution, volumetric and multiparametric 3D single-cell analysis.
    Nat Commun Volume: 15 Page(s): 1975
    03/04/2024 Authors: Hua X; Han K; Mandracchia B; Radmand A; Liu W; Kim H; Yuan Z; Ehrlich SM; Li K; Zheng C
  • Multivalent Targeting of the Asialoglycoprotein Receptor by Virus-Like Particles.
    Small Volume: 19 Page(s): e2304263
    12/01/2023 Authors: Hincapie R; Bhattacharya S; Baksh MM; Sanhueza CA; Echeverri ES; Kim H; Paunovska K; Podilapu AR; Xu M; Dahlman JE
  • Drug delivery systems for CRISPR-based genome editors.
    Nat Rev Drug Discov Volume: 22 Page(s): 875 - 894
    11/01/2023 Authors: Madigan V; Zhang F; Dahlman JE
  • Small interfering RNA-mediated allele-selective silencing of von Willebrand factor invitro and invivo.
    Blood Adv Volume: 7 Page(s): 6108 - 6119
    10/24/2023 Authors: Jongejan YK; Schrader Echeverri E; Dirven RJ; Paunovska K; Linthorst NA; de Jong A; Wellershoff JC; van der Gouw KD; van Vlijmen BJM; Dahlman JE
  • AMELIORATION OF A VON WILLEBRAND DISEASE TYPE 2B PHENOTYPE IN VIVO USING ALLELE-SELECTIVE SMALL INTERFERING RNAS
    Volume: 29 Page(s): 10 - 11
    09/01/2023 Authors: Linthorst N; Jongejan Y; Bierings R; Dahlman J; Denis C; Leebeek F; Schrader E; Voorberg J; Van Vlijmen B; Eikenboom J
  • High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo.
    J Control Release Volume: 357 Page(s): 394 - 403
    05/01/2023 Authors: Huayamares SG; Lokugamage MP; Rab R; Da Silva Sanchez AJ; Kim H; Radmand A; Loughrey D; Lian L; Hou Y; Achyut BR
  • Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery.
    Nat Chem Volume: 15 Page(s): 508 - 515
    04/01/2023 Authors: Hatit MZC; Dobrowolski CN; Lokugamage MP; Loughrey D; Ni H; Zurla C; Da Silva Sanchez AJ; Radmand A; Huayamares SG; Zenhausern R
  • The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo.
    Nano Lett Volume: 23 Page(s): 993 - 1002
    02/08/2023 Authors: Radmand A; Lokugamage MP; Kim H; Dobrowolski C; Zenhausern R; Loughrey D; Huayamares SG; Hatit MZC; Ni H; Del Cid A
  • Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases.
    J Extracell Vesicles Volume: 12 Page(s): e12305
    02/01/2023 Authors: Li G; Chen T; Dahlman J; Eniola-Adefeso L; Ghiran IC; Kurre P; Lam WA; Lang JK; Marbn E; Martn P
  • Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery.
    J Control Release Volume: 353 Page(s): 270 - 277
    01/01/2023 Authors: Da Silva Sanchez AJ; Zhao K; Huayamares SG; Hatit MZC; Lokugamage MP; Loughrey D; Dobrowolski C; Wang S; Kim H; Paunovska K
  • The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid Structure.
    Nano Lett Volume: 22 Page(s): 10025 - 10033
    12/28/2022 Authors: Paunovska K; Da Silva Sanchez AJ; Lokugamage MP; Loughrey D; Echeverri ES; Cristian A; Hatit MZC; Santangelo PJ; Zhao K; Dahlman JE
  • What are the current bottlenecks in developing and applying CRISPR technologies?
    Cell Syst Volume: 13 Page(s): 589 - 593
    08/17/2022 Authors: Kellogg EH; Gootenberg J; Abudayyeh O; Wong ASL; Dahlman JE; Lapinaite A; Myhrvold C; Liu CC; Hsu PD; Mali P
  • Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo.
    Nat Commun Volume: 13 Page(s): 4766
    08/15/2022 Authors: Ni H; Hatit MZC; Zhao K; Loughrey D; Lokugamage MP; Peck HE; Cid AD; Muralidharan A; Kim Y; Santangelo PJ
  • Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery.
    Nat Nanotechnol Volume: 17 Page(s): 871 - 879
    08/01/2022 Authors: Dobrowolski C; Paunovska K; Schrader Echeverri E; Loughrey D; Da Silva Sanchez AJ; Ni H; Hatit MZC; Lokugamage MP; Kuzminich Y; Peck HE
  • Universal Barcoding Predicts In Vivo ApoE-Independent Lipid Nanoparticle Delivery.
    Nano Lett Volume: 22 Page(s): 4822 - 4830
    06/22/2022 Authors: Da Silva Sanchez AJ; Dobrowolski C; Cristian A; Echeverri ES; Zhao K; Hatit MZC; Loughrey D; Paunovska K; Dahlman JE
  • Drug delivery systems for RNA therapeutics.
    Nat Rev Genet Volume: 23 Page(s): 265 - 280
    05/01/2022 Authors: Paunovska K; Loughrey D; Dahlman JE
  • Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles.
    Nat Nanotechnol Volume: 17 Page(s): 310 - 318
    03/01/2022 Authors: Hatit MZC; Lokugamage MP; Dobrowolski CN; Paunovska K; Ni H; Zhao K; Vanover D; Beyersdorf J; Peck HE; Loughrey D
  • Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver.
    Nat Biomed Eng Volume: 6 Page(s): 157 - 167
    02/01/2022 Authors: Sago CD; Lokugamage MP; Loughrey D; Lindsay KE; Hincapie R; Krupczak BR; Kalathoor S; Sato M; Echeverri ES; Fitzgerald JP
  • Non-liver mRNA Delivery.
    Acc Chem Res Volume: 55 Page(s): 13 - 23
    01/04/2022 Authors: Loughrey D; Dahlman JE
  • Dataset of bond enthalpies (AA, AB, BB) in 975 binary intermetallic compounds.
    Data Brief Volume: 39 Page(s): 107652
    12/01/2021 Authors: Miracle D; Dahlman A; Wilks G; Dahlman JE
  • Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs.
    Nat Biomed Eng Volume: 5 Page(s): 1059 - 1068
    09/01/2021 Authors: Lokugamage MP; Vanover D; Beyersdorf J; Hatit MZC; Rotolo L; Echeverri ES; Peck HE; Ni H; Yoon J-K; Kim Y
  • Therapeutic RNA Delivery for COVID and Other Diseases.
    Adv Healthc Mater Volume: 10 Page(s): e2002022
    08/01/2021 Authors: Dobrowolski C; Paunovska K; Hatit MZC; Lokugamage MP; Dahlman JE
  • Frataxin deficiency promotes endothelial senescence in pulmonary hypertension.
    J Clin Invest Volume: 131
    06/01/2021 Authors: Culley MK; Zhao J; Tai YY; Tang Y; Perk D; Negi V; Yu Q; Woodcock C-SC; Handen A; Speyer G
  • The NIH Somatic Cell Genome Editing program.
    Nature Volume: 592 Page(s): 195 - 204
    04/01/2021 Authors: Saha K; Sontheimer EJ; Brooks PJ; Dwinell MR; Gersbach CA; Liu DR; Murray SA; Tsai SQ; Wilson RC; Anderson DG
  • Voices of biotech research.
    Nat Biotechnol Volume: 39 Page(s): 281 - 286
    03/01/2021 Authors: Annabi N; Baker M; Boettiger A; Chakraborty D; Chen Y; Corbett KS; Correia B; Dahlman J; de Oliveira T; Ertuerk A
  • Whither COVID-19 vaccines?
    Nat Biotechnol Volume: 38 Page(s): 1132 - 1145
    10/01/2020 Authors: DeFrancesco L
  • Treating Cystic Fibrosis with mRNA and CRISPR.
    Hum Gene Ther Volume: 31 Page(s): 940 - 955
    09/01/2020 Authors: Da Silva Sanchez A; Paunovska K; Cristian A; Dahlman JE
  • Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands.
    Bioeng Transl Med Volume: 5 Page(s): e10161
    09/01/2020 Authors: Gan Z; Lokugamage MP; Hatit MZC; Loughrey D; Paunovska K; Sato M; Cristian A; Dahlman JE
  • Increased PIP3 activity blocks nanoparticle mRNA delivery.
    Sci Adv Volume: 6 Page(s): eaba5672
    07/01/2020 Authors: Paunovska K; Da Silva Sanchez A; Foster MT; Loughrey D; Blanchard EL; Islam FZ; Gan Z; Mantalaris A; Santangelo PJ; Dahlman JE
  • Mild Innate Immune Activation Overrides Efficient Nanoparticle-Mediated RNA Delivery
    Volume: 28 Page(s): 465 - 465
    04/28/2020 Authors: Lokugamage M; Dahlman J
  • Nanoparticles Containing Oxidized Cholesterol Improve mRNA Delivery In Vivo
    Volume: 28 Page(s): 450 - 451
    04/28/2020 Authors: Paunovska K; Dahlman JE
  • Mild Innate Immune Activation Overrides Efficient Nanoparticle-Mediated RNA Delivery.
    Adv Mater Volume: 32 Page(s): e1904905
    01/01/2020 Authors: Lokugamage MP; Gan Z; Zurla C; Levin J; Islam FZ; Kalathoor S; Sato M; Sago CD; Santangelo PJ; Dahlman JE
  • Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing.
    Nucleic Acid Ther Volume: 29 Page(s): 231 - 244
    10/01/2019 Authors: Brown JM; Dahlman JE; Neuman KK; Prata CAH; Krampert MC; Hadwiger PM; Vornlocher H-P
  • Using Large Datasets to Understand Nanotechnology.
    Adv Mater Volume: 31 Page(s): e1902798
    10/01/2019 Authors: Paunovska K; Loughrey D; Sago CD; Langer R; Dahlman JE
  • Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands.
    Adv Mater Volume: 31 Page(s): e1902251
    10/01/2019 Authors: Lokugamage MP; Sago CD; Gan Z; Krupczak BR; Dahlman JE
  • Cell Subtypes Within the Liver Microenvironment Differentially Interact with Lipid Nanoparticles.
    Cell Mol Bioeng Volume: 12 Page(s): 389 - 397
    10/01/2019 Authors: Sago CD; Krupczak BR; Lokugamage MP; Gan Z; Dahlman JE
  • Endothelial TGF- signalling drives vascular inflammation and atherosclerosis.
    Nat Metab Volume: 1 Page(s): 912 - 926
    09/01/2019 Authors: Chen P-Y; Qin L; Li G; Wang Z; Dahlman JE; Malagon-Lopez J; Gujja S; Cilfone NA; Kauffman KJ; Sun L
  • Rapidly identifying nanoparticles for in vivo RNA and gene editing using DNA barcoding
    Volume: 258
    08/25/2019 Authors: Dahlman J
  • All the World's Data Could Fit in an Egg.
    Sci Am Volume: 320 Page(s): 68
    06/01/2019 Authors: Dahlman J
  • BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.
    Volume: 139 Page(s): 2238 - 2255
    05/07/2019 Authors: Yu Q; Tai Y-Y; Tang Y; Zhao J; Negi V; Culley MK; Pilli J; Sun W; Brugger K; Mayr J
  • Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses.
    Adv Mater Volume: 31 Page(s): e1807748
    04/01/2019 Authors: Paunovska K; Da Silva Sanchez AJ; Sago CD; Gan Z; Lokugamage MP; Islam FZ; Kalathoor S; Krupczak BR; Dahlman JE
  • Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution.
    J Am Chem Soc Volume: 140 Page(s): 17095 - 17105
    12/12/2018 Authors: Sago CD; Lokugamage MP; Islam FZ; Krupczak BR; Sato M; Dahlman JE
  • Modifying a Commonly Expressed Endocytic Receptor Retargets Nanoparticles in Vivo.
    Nano Lett Volume: 18 Page(s): 7590 - 7600
    12/12/2018 Authors: Sago CD; Lokugamage MP; Lando GN; Djeddar N; Shah NN; Syed C; Bryksin AV; Dahlman JE
  • Barcoding chemical modifications into nucleic acids improves drug stability in vivo.
    J Mater Chem B Volume: 6 Page(s): 7197 - 7203
    11/28/2018 Authors: Sago CD; Kalathoor S; Fitzgerald JP; Lando GN; Djeddar N; Bryksin AV; Dahlman JE
  • Correction for Sago et al., High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing.
    Proc Natl Acad Sci U S A Volume: 115 Page(s): E11427
    11/27/2018
  • Editing nature: Local roots of global governance.
    Science Volume: 362 Page(s): 527 - 529
    11/02/2018 Authors: Kofler N; Collins JP; Kuzma J; Marris E; Esvelt K; Nelson MP; Newhouse A; Rothschild LJ; Vigliotti VS; Semenov M
  • High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing.
    Proc Natl Acad Sci U S A Volume: 115 Page(s): E9944 - E9952
    10/16/2018 Authors: Sago CD; Lokugamage MP; Paunovska K; Vanover DA; Monaco CM; Shah NN; Gamboa Castro M; Anderson SE; Rudoltz TG; Lando GN
  • Testing thousands of nanoparticles in vivo using DNA barcodes.
    Curr Opin Biomed Eng Volume: 7 Page(s): 1 - 8
    09/01/2018 Authors: Lokugamage MP; Sago CD; Dahlman JE
  • Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery.
    ACS Nano Volume: 12 Page(s): 8341 - 8349
    08/28/2018 Authors: Paunovska K; Gil CJ; Lokugamage MP; Sago CD; Sato M; Lando GN; Gamboa Castro M; Bryksin AV; Dahlman JE
  • A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation.
    Nano Lett Volume: 18 Page(s): 2148 - 2157
    03/14/2018 Authors: Paunovska K; Sago CD; Monaco CM; Hudson WH; Castro MG; Rudoltz TG; Kalathoor S; Vanover DA; Santangelo PJ; Ahmed R
  • Inhibiting Integrin 5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis.
    J Am Heart Assoc Volume: 7
    01/30/2018 Authors: Budatha M; Zhang J; Zhuang ZW; Yun S; Dahlman JE; Anderson DG; Schwartz MA
  • CD73-Mediated Adenosine Production by Mesenchymal Stromal Cells Reduces the Innate Inflammatory Response Following Myocardial Ischemia/Reperfusion Injury
    Volume: 136
    11/14/2017 Authors: Shin EY; Wang L; Zemskova M; Deppen J; Xu K; Garcia AJ; Dahlman J; Tirouvanziam R; Levit RD
  • Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics.
    Proc Natl Acad Sci U S A Volume: 114 Page(s): 2060 - 2065
    02/21/2017 Authors: Dahlman JE; Kauffman KJ; Xing Y; Shaw TE; Mir FF; Dlott CC; Langer R; Anderson DG; Wang ET
  • Interaction between integrin 5 and PDE4D regulates endothelial inflammatory signalling.
    Nat Cell Biol Volume: 18 Page(s): 1043 - 1053
    10/01/2016 Authors: Yun S; Budatha M; Dahlman JE; Coon BG; Cameron RT; Langer R; Anderson DG; Baillie G; Schwartz MA
  • Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
    Circ Res Volume: 119 Page(s): 853 - 864
    09/16/2016 Authors: Sager HB; Hulsmans M; Lavine KJ; Moreira MB; Heidt T; Courties G; Sun Y; Iwamoto Y; Tricot B; Khan OF
  • Nanoparticle-enabled RNAi in endothelial cells attenuates inflammation in atherosclerosis and acute myocardial infarction
    Volume: 37 Page(s): 989 - 989
    08/01/2016 Authors: Sager H; Dutta P; Dahlman J; Hulsmans M; Courties G; Sun Y; Heidt T; Borodovsky A; Fitzgerald K; Libby P
  • RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction.
    Sci Transl Med Volume: 8 Page(s): 342ra80
    06/08/2016 Authors: Sager HB; Dutta P; Dahlman JE; Hulsmans M; Courties G; Sun Y; Heidt T; Vinegoni C; Borodovsky A; Fitzgerald K
  • Challenges in carrier-mediated intracellular delivery: moving beyond endosomal barriers.
    Wiley Interdiscip Rev Nanomed Nanobiotechnol Volume: 8 Page(s): 465 - 478
    05/01/2016 Authors: Stewart MP; Lorenz A; Dahlman J; Sahay G
  • Emerging Frontiers in Drug Delivery.
    J Am Chem Soc Volume: 138 Page(s): 704 - 717
    01/27/2016 Authors: Tibbitt MW; Dahlman JE; Langer R
  • Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease.
    Nat Biotechnol Volume: 33 Page(s): 1159 - 1161
    11/01/2015 Authors: Dahlman JE; Abudayyeh OO; Joung J; Gootenberg JS; Zhang F; Konermann S
  • Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure.
    Arterioscler Thromb Vasc Biol Volume: 35 Page(s): 2343 - 2353
    11/01/2015 Authors: Koga J-I; Nakano T; Dahlman JE; Figueiredo J-L; Zhang H; Decano J; Khan OF; Niida T; Iwata H; Aster JC
  • Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.
    EMBO Mol Med Volume: 7 Page(s): 695 - 713
    06/01/2015 Authors: White K; Lu Y; Annis S; Hale AE; Chau BN; Dahlman JE; Hemann C; Opotowsky AR; Vargas SO; Rosas I
  • Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature.
    Nano Lett Volume: 15 Page(s): 3008 - 3016
    05/13/2015 Authors: Khan OF; Zaia EW; Jhunjhunwala S; Xue W; Cai W; Yun DS; Barnes CM; Dahlman JE; Dong Y; Pelet JM
  • Ionizable amphiphilic dendrimer-based nanomaterials with alkyl-chain-substituted amines for tunable siRNA delivery to the liver endothelium in vivo.
    Angew Chem Int Ed Engl Volume: 53 Page(s): 14397 - 14401
    12/22/2014 Authors: Khan OF; Zaia EW; Yin H; Bogorad RL; Pelet JM; Webber MJ; Zhuang I; Dahlman JE; Langer R; Anderson DG
  • Loss of -catenin elicits a cholestatic response and impairs liver regeneration.
    Sci Rep Volume: 4 Page(s): 6835
    10/30/2014 Authors: Herr KJ; Tsang Y-HN; Ong JWE; Li Q; Yap LL; Yu W; Yin H; Bogorad RL; Dahlman JE; Chan YG
  • CRISPR-Cas9 knockin mice for genome editing and cancer modeling.
    Cell Volume: 159 Page(s): 440 - 455
    10/09/2014 Authors: Platt RJ; Chen S; Zhou Y; Yim MJ; Swiech L; Kempton HR; Dahlman JE; Parnas O; Eisenhaure TM; Jovanovic M
  • Small RNA combination therapy for lung cancer.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): E3553 - E3561
    08/26/2014 Authors: Xue W; Dahlman JE; Tammela T; Khan OF; Sood S; Dave A; Cai W; Chirino LM; Yang GR; Bronson R
  • A lesson in communication.
    Nat Nanotechnol Volume: 9 Page(s): 656
    08/01/2014 Authors: Dahlman JE
  • In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.
    Nat Nanotechnol Volume: 9 Page(s): 648 - 655
    08/01/2014 Authors: Dahlman JE; Barnes C; Khan O; Thiriot A; Jhunjunwala S; Shaw TE; Xing Y; Sager HB; Sahay G; Speciner L
  • Nanotechnology for in vivo targeted siRNA delivery.
    Volume: 88 Page(s): 37 - 69
    01/01/2014 Authors: Dahlman JE; Kauffman KJ; Langer R; Anderson DG
  • Alkane-modified short polyethyleneimine for siRNA delivery.
    J Control Release Volume: 160 Page(s): 172 - 176
    06/10/2012 Authors: Schroeder A; Dahlman JE; Sahay G; Love KT; Jiang S; Eltoukhy AA; Levins CG; Wang Y; Anderson DG
  • Treating metastatic cancer with nanotechnology.
    Nat Rev Cancer Volume: 12 Page(s): 39 - 50
    12/23/2011 Authors: Schroeder A; Heller DA; Winslow MM; Dahlman JE; Pratt GW; Langer R; Jacks T; Anderson DG
  • Silencing or stimulation? siRNA delivery and the immune system.
    Annu Rev Chem Biomol Eng Volume: 2 Page(s): 77 - 96
    01/01/2011 Authors: Whitehead KA; Dahlman JE; Langer RS; Anderson DG
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