Joseph Cubells MD/PhD

Department of Human Genetics
Professor

(404) 727-2005
jcubell@emory.edu
Website

Emory University School of Medicine
Human Genetics
615 Michael Street, Suite 301
Emory Autism Center
1551 Shoup Court

Overview

Joe Cubells is a Professor in the Departments of Human Genetics and Psychiatry and Behavioral Sciences at the Emory University School of Medicine. His research focuses on genomic disorders associated with autism spectrum disorder (ASD), schizophrenia, and other neurodevelopmental disorders. Clinically, he provides psychiatric care to adults with ASD and related disorders.

Academic Appointment

Professor, Human Genetics, Emory University School of Medicine
Professor, Emory University School of Medicine
Professor, Human Genetics, and Psychiatry and Behavioral Sciences, Emory University School of Medicine
Professor, Psychiatry and Behavioral Sciences, Emory University School of Medicine
Professor, Human Genetics, Emory University School of Medicine

Education

Degrees

MD from Albert Einstein College of Medicine
BA from Johns Hopkins University
PhD from Albert Einstein College of Medicine

Research

Focus

My research focuses broadly on understanding molecular-genetic contributions to neuro-developmental and psychiatric disorders. Special areas of interest include (1) psychiatric manifestations of copy-number-variant (CNV) disorders such as 22q11 deletion syndrome, 15q13.3 deletion syndrome, William syndrome, etc, and in other molecularly defined disorders such as Fragile X syndrome, Praeder Willi syndrome and Rett syndrome.

Publications

Random forest and Shapley Additive exPlanations predict oxytocin targeted effects on brain functional networks involved in salience and sensorimotor processing, in a randomized clinical trial in autism.
Neuropsychopharmacology
04/02/2025 Authors: Andari E; Gopinath K; O'Leary E; Caceres GA; Nishitani S; Smith AK; Ousley O; Rilling JK; Cubells JF; Young LJ
Beyond IQ: executive function deficits and their relation to functional, clinical, and neuroimaging outcomes in 3q29 deletion syndrome.
Psychol Med Volume: 54 Page(s): 1 - 12
10/04/2024 Authors: Pollak RM; Sefik E; Aberizk K; Duan K; Espana R; Guest RM; Goldman-Yassen AE; Goines K; Novacek DM; Saulnier CA
Return of genetic research results in 21,532 individuals with autism.
Genet Med Volume: 26 Page(s): 101202
10/01/2024 Authors: Wright JR; Astrovskaya I; Barns SD; Goler A; Zhou X; Shu C; Snyder LG; Han B; SPARK Consortium; Shen Y
Visual-Motor Integration Deficits in 3q29 Deletion Syndrome.
J Autism Dev Disord Volume: 54 Page(s): 3142 - 3154
08/01/2024 Authors: Pollak RM; Burrell TL; Cubells JF; Klaiman C; Murphy MM; Saulnier CA; Walker EF; White SP; Mulle JG
Reduced amplitude and slowed latency of the acoustic startle response in adolescents and adults with 22q11.2 deletion syndrome.
Schizophr Res Volume: 269 Page(s): 9 - 17
07/01/2024 Authors: Parker DA; Imes S; Ruban G; Ousley OY; Henshey B; Massa NM; Walker E; Cubells JF; Duncan E
Psychosis spectrum symptoms among individuals with schizophrenia-associated copy number variants and evidence of cerebellar correlates of symptom severity.
Psychiatry Res Volume: 335 Page(s): 115867
05/01/2024 Authors: Sefik E; Guest RM; Aberizk K; Espana R; Goines K; Novacek DM; Murphy MM; Goldman-Yassen AE; Cubells JF; Ousley O
Adaptive behaviour deficits in individuals with 3q29 deletion syndrome.
J Intellect Disabil Res Volume: 68 Page(s): 113 - 127
02/01/2024 Authors: Pollak RM; Burrell TL; Cubells JF; Klaiman C; Murphy MM; Saulnier CA; Walker EF; White SP; Mulle JG
Deep psychophysiological phenotyping of adolescents and adults with 22q11.2 deletion syndrome: a multilevel approach to defining core disease processes.
BMC Psychiatry Volume: 23 Page(s): 425
06/13/2023 Authors: Parker DA; Cubells JF; Imes SL; Ruban GA; Henshey BT; Massa NM; Walker EF; Duncan EJ; Ousley OY
Adaptive behavior deficits in individuals with 3q29 deletion syndrome.
medRxiv
04/03/2023 Authors: Pollak RM; Burrell TL; Cubells JF; Klaiman C; Murphy MM; Saulnier CA; Walker EF; White SP; Mulle JG
A distinct cognitive profile in individuals with 3q29 deletion syndrome.
J Intellect Disabil Res Volume: 67 Page(s): 216 - 227
03/01/2023 Authors: Klaiman C; White SP; Saulnier C; Murphy M; Burrell L; Cubells J; Walker E; Emory 3q29 Project; Mulle JG
Autism spectrum disorder symptom expression in individuals with 3q29 deletion syndrome.
Mol Autism Volume: 13 Page(s): 50
12/24/2022 Authors: Pollak RM; Pincus JE; Burrell TL; Cubells JF; Klaiman C; Murphy MM; Saulnier CA; Walker EF; White SP; Mulle JG
Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes.
Nat Genet Volume: 54 Page(s): 1305 - 1319
09/01/2022 Authors: Zhou X; Feliciano P; Shu C; Wang T; Astrovskaya I; Hall JB; Obiajulu JU; Wright JR; Murali SC; Xu SX
A normative chart for cognitive development in a genetically selected population.
Neuropsychopharmacology Volume: 47 Page(s): 1379 - 1386
06/01/2022 Authors: Fiksinski AM; Bearden CE; Bassett AS; Kahn RS; Zinkstok JR; Hooper SR; Tempelaar W; McDonald-McGinn D; Swillen A; Emanuel B
Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.
Mol Psychiatry Volume: 26 Page(s): 4496 - 4510
08/01/2021 Authors: Cleynen I; Engchuan W; Hestand MS; Heung T; Holleman AM; Johnston HR; Monfeuga T; McDonald-McGinn DM; Gur RE; Morrow BE
Craniofacial features of 3q29 deletion syndrome: Application of next-generation phenotyping technology.
Am J Med Genet A Volume: 185 Page(s): 2094 - 2101
07/01/2021 Authors: Mak BC; Sanchez Russo R; Gambello MJ; Fleischer N; Black ED; Leslie E; Murphy MM; Emory 3q29 Project; Mulle JG
Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome.
Transl Psychiatry Volume: 11 Page(s): 357
06/15/2021 Authors: Sefik E; Purcell RH; Emory 3q29 Project; Walker EF; Bassell GJ; Mulle JG
Oxytocin Dose-Dependent Effects on Brain Function During a Socially Dynamic Game in Autism Spectrum Disorders
Volume: 89 Page(s): S114 - S114
05/01/2021 Authors: Andari E; Cotton A; Cubells J; Rilling J; Young L
Deep phenotyping in 3q29 deletion syndrome: recommendations for clinical care.
Genet Med Volume: 23 Page(s): 872 - 880
05/01/2021 Authors: Sanchez Russo R; Gambello MJ; Murphy MM; Aberizk K; Black E; Burrell TL; Carlock G; Cubells JF; Epstein MT; Espana R
The role of oxytocin signaling in depression and suicidality in returning war veterans.
Psychoneuroendocrinology Volume: 126 Page(s): 105085
04/01/2021 Authors: Warrener CD; Valentin EM; Gallin C; Richey L; Ross DB; Hood CJ; Lori A; Cubells J; Rauch SAM; Rilling JK
Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome.
Nat Med Volume: 26 Page(s): 1912 - 1918
12/01/2020 Authors: Davies RW; Fiksinski AM; Breetvelt EJ; Williams NM; Hooper SR; Monfeuga T; Bassett AS; Owen MJ; Gur RE; Morrow BE
Psychiatric and Medical Profiles of Autistic Adults in the SPARK Cohort.
J Autism Dev Disord Volume: 50 Page(s): 3679 - 3698
10/01/2020 Authors: Fombonne E; Green Snyder L; Daniels A; Feliciano P; Chung W; SPARK Consortium
A Double-Blind, Randomized, Placebo-Controlled Clinical Study of Trofinetide in the Treatment of Fragile X Syndrome.
Pediatr Neurol Volume: 110 Page(s): 30 - 41
09/01/2020 Authors: Berry-Kravis E; Horrigan JP; Tartaglia N; Hagerman R; Kolevzon A; Erickson CA; Hatti S; Snape M; Yaroshinsky A; Stoms G
Meaning in Measurement: Evaluating Young Autistic Adults' Active Engagement and Expressed Interest in Quality-of-Life Goals.
Autism Adulthood Volume: 2 Page(s): 227 - 242
09/01/2020 Authors: Bernhardt JB; Lam GYH; Thomas T; Cubells JF; Bohlke K; Reid M; Rice CE
Epigenetic modification of the oxytocin receptor gene: implications for autism symptom severity and brain functional connectivity.
Neuropsychopharmacology Volume: 45 Page(s): 1150 - 1158
06/01/2020 Authors: Andari E; Nishitani S; Kaundinya G; Caceres GA; Morrier MJ; Ousley O; Smith AK; Cubells JF; Young LJ
Comprehensive phenotyping of neuropsychiatric traits in a multiplex 3q29 deletion family: a case report.
BMC Psychiatry Volume: 20 Page(s): 184
04/22/2020 Authors: Murphy MM; Burrell TL; Cubells JF; Epstein MT; Espana R; Gambello MJ; Goines K; Klaiman C; Koh S; Russo RS
Beliefs in vaccine as causes of autism among SPARK cohort caregivers.
Vaccine Volume: 38 Page(s): 1794 - 1803
02/11/2020 Authors: Fombonne E; Goin-Kochel RP; O'Roak BJ; SPARK Consortium
Epigenetic Modifications of the Oxytocin Receptor Gene and Autism Spectrum Disorders
Volume: 44 Page(s): 98 - 98
12/01/2019 Authors: Andari E; Nishitani S; Kaundinya G; Caceres G; Morrier M; Ousley O; Smith A; Cubells J; Young L
Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes.
NPJ Genom Med Volume: 4 Page(s): 19
01/01/2019 Authors: Feliciano P; Zhou X; Astrovskaya I; Turner TN; Wang T; Brueggeman L; Barnard R; Hsieh A; Snyder LG; Muzny DM
Targeted Action of Intranasal Oxytocin on Brain Functional Connectivity in Adults With Autism Spectrum Disorder
Volume: 43 Page(s): S245 - S245
12/01/2018 Authors: Andari E; Kaundinya G; Caceres G; Ousley O; Morrier M; Rilling J; Cubells J; Young L
Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects.
Am J Med Genet A Volume: 176 Page(s): 2172 - 2181
10/01/2018 Authors: Zhao Y; Guo T; Fiksinski A; Breetvelt E; McDonald-McGinn DM; Crowley TB; Diacou A; Schneider M; Eliez S; Swillen A
Retraction Notice to: Nested Inversion Polymorphisms Predispose Chromosome 22q11.2 to Meiotic Rearrangements.
Am J Hum Genet Volume: 103 Page(s): 457
09/06/2018 Authors: Demaerel W; Hestand MS; Vergaelen E; Swillen A; Lpez-Snchez M; Prez-Jurado LA; McDonald-McGinn DM; Zackai E; Emanuel BS; Morrow BE
Study protocol for The Emory 3q29 Project: evaluation of neurodevelopmental, psychiatric, and medical symptoms in 3q29 deletion syndrome.
BMC Psychiatry Volume: 18 Page(s): 183
06/08/2018 Authors: Murphy MM; Lindsey Burrell T; Cubells JF; Espaa RA; Gambello MJ; Goines KCB; Klaiman C; Li L; Novacek DM; Papetti A
Associations between the DBH gene, plasma dopamine -hydroxylase activity and cognitive measures in Han Chinese patients with schizophrenia.
Schizophr Res Volume: 193 Page(s): 58 - 63
03/01/2018 Authors: Sun Z; Ma Y; Li W; He J; Li J; Yang X; Mao P; Cubells JF; Tang Y-L
SPARK: A US Cohort of 50,000 Families to Accelerate Autism Research.
Neuron Volume: 97 Page(s): 488 - 493
02/07/2018 Authors: SPARK Consortium. Electronic address: pfeliciano@simonsfoundation.org; SPARK Consortium
Brief Report: Relationship Between ADOS-2, Module 4 Calibrated Severity Scores (CSS) and Social and Non-Social Standardized Assessment Measures in Adult Males with Autism Spectrum Disorder (ASD).
J Autism Dev Disord Volume: 47 Page(s): 4018 - 4024
12/01/2017 Authors: Morrier MJ; Ousley OY; Caceres-Gamundi GA; Segall MJ; Cubells JF; Young LJ; Andari E
Rare Genome-Wide Copy Number Variation and Expression of Schizophrenia in 22q11.2 Deletion Syndrome.
Am J Psychiatry Volume: 174 Page(s): 1054 - 1063
11/01/2017 Authors: Bassett AS; Lowther C; Merico D; Costain G; Chow EWC; van Amelsvoort T; McDonald-McGinn D; Gur RE; Swillen A; Van den Bree M
Nested Inversion Polymorphisms Predispose Chromosome 22q11.2 to Meiotic Rearrangements.
Am J Hum Genet Volume: 101 Page(s): 616 - 622
10/05/2017 Authors: Demaerel W; Hestand MS; Vergaelen E; Swillen A; Lpez-Snchez M; Prez-Jurado LA; McDonald-McGinn DM; Zackai E; Emanuel BS; Morrow BE
Subthreshold Psychosis in 22q11.2 Deletion Syndrome: Multisite Naturalistic Study.
Schizophr Bull Volume: 43 Page(s): 1079 - 1089
09/01/2017 Authors: Weisman O; Guri Y; Gur RE; McDonald-McGinn DM; Calkins ME; Tang SX; Emanuel B; Zackai EH; Eliez S; Schneider M
Examining the Overlap between Autism Spectrum Disorder and 22q11.2 Deletion Syndrome.
Int J Mol Sci Volume: 18
05/18/2017 Authors: Ousley O; Evans AN; Fernandez-Carriba S; Smearman EL; Rockers K; Morrier MJ; Evans DW; Coleman K; Cubells J
PEMapper and PECaller provide a simplified approach to whole-genome sequencing.
Proc Natl Acad Sci U S A Volume: 114 Page(s): E1923 - E1932
03/07/2017 Authors: Johnston HR; Chopra P; Wingo TS; Patel V; International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome; Epstein MP; Mulle JG; Warren ST; Zwick ME; Cutler DJ
An epigenetic clock for gestational age at birth based on blood methylation data.
Genome Biol Volume: 17 Page(s): 206
10/07/2016 Authors: Knight AK; Craig JM; Theda C; Bkvad-Hansen M; Bybjerg-Grauholm J; Hansen CS; Hollegaard MV; Hougaard DM; Mortensen PB; Weinsheimer SM
An epigenetic clock for gestational age at birth based on blood methylation data
BREAST CANCER RESEARCH Volume: 17
10/07/2016 Authors: Knight AK; Craig JM; Theda C; Baekvad-Hansen M; Bybjerg-Grauholm J; Hansen CS; Hollegaard MV; Hougaard DM; Mortensen PB; Weinsheimer SM
Analysis of Rare Variants in ADRA1a with Response to Treatment for Major Depressive Disorder (MDD)
Volume: 79 Page(s): 225S - 226S
05/01/2016 Authors: Lori A; Carillo-Roa T; Binder EB; Mayberg HS; McGrath CL; Mletzko T; Laird JL; Czamara D; Dunlop BW; Craighead WE
Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine -Hydroxylase Knockout Mice.
PLoS One Volume: 11 Page(s): e0154864
01/01/2016 Authors: Cubells JF; Schroeder JP; Barrie ES; Manvich DF; Sadee W; Berg T; Mercer K; Stowe TA; Liles LC; Squires KE
The effect of hypocalcemia in early childhood on autism-related social and communication skills in patients with 22q11 deletion syndrome.
Eur Arch Psychiatry Clin Neurosci Volume: 265 Page(s): 519 - 524
09/01/2015 Authors: Muldoon M; Ousley OY; Kobrynski LJ; Patel S; Oster ME; Fernandez-Carriba S; Cubells JF; Coleman K; Pearce BD
Association of Rare Variants in ADRA1a with Response to Treatment for Major Depressive Disorder (MDD)
Volume: 77
05/01/2015 Authors: Lori A; Tania C-R; Binder EB; Mayberg HS; McGrath CL; Mletzko TC; Dunlop BW; Craighead EW; Kelley ME; Mulle JG
Cognitive decline preceding the onset of psychosis in patients with 22q11.2 deletion syndrome.
JAMA Psychiatry Volume: 72 Page(s): 377 - 385
04/01/2015 Authors: Vorstman JAS; Breetvelt EJ; Duijff SN; Eliez S; Schneider M; Jalbrzikowski M; Armando M; Vicari S; Shashi V; Hooper SR
Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity.
Circ Res Volume: 115 Page(s): 1017 - 1025
12/05/2014 Authors: Barrie ES; Weinshenker D; Verma A; Pendergrass SA; Lange LA; Ritchie MD; Wilson JG; Kuivaniemi H; Tromp G; Carey DJ
Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment.
Drug Alcohol Depend Volume: 136 Page(s): 36 - 42
03/01/2014 Authors: Schottenfeld RS; Chawarski MC; Cubells JF; George TP; Lappalainen J; Kosten TR
Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills.
Proc Natl Acad Sci U S A Volume: 111 Page(s): 1987 - 1992
02/04/2014 Authors: Skuse DH; Lori A; Cubells JF; Lee I; Conneely KN; Puura K; Lehtimki T; Binder EB; Young LJ
Effect of COMT Val(158)Met genotype on nicotine withdrawal-related cognitive dysfunction in smokers with and without schizophrenia.
Schizophr Res Volume: 150 Page(s): 602 - 603
11/01/2013 Authors: Wing VC; Tang Y-L; Sacco KA; Cubells JF; George TP
Axis I psychiatric diagnoses in adolescents and young adults with 22q11 deletion syndrome.
Eur Psychiatry Volume: 28 Page(s): 417 - 422
09/01/2013 Authors: Ousley OY; Smearman E; Fernandez-Carriba S; Rockers KA; Coleman K; Walker EF; Cubells JF
Prevalence of autism spectrum disorders in China.
Shanghai Arch Psychiatry Volume: 25 Page(s): 176 - 177
06/01/2013 Authors: Cubells JF
Sex dependent influence of a functional polymorphism in steroid 5--reductase type 2 (SRD5A2) on post-traumatic stress symptoms.
Am J Med Genet B Neuropsychiatr Genet Volume: 162B Page(s): 283 - 292
04/01/2013 Authors: Gillespie CF; Almli LM; Smith AK; Bradley B; Kerley K; Crain DF; Mercer KB; Weiss T; Phifer J; Tang Y
Alcohol and alcohol-related harm in China: policy changes needed.
Bull World Health Organ Volume: 91 Page(s): 270 - 276
04/01/2013 Authors: Tang Y-L; Xiang X-J; Wang X-Y; Cubells JF; Babor TF; Hao W
The gut microbiome: a new frontier in autism research.
Curr Psychiatry Rep Volume: 15 Page(s): 337
02/01/2013 Authors: Mulle JG; Sharp WG; Cubells JF
Prodromal and autistic symptoms in schizotypal personality disorder and 22q11.2 deletion syndrome.
J Abnorm Psychol Volume: 122 Page(s): 238 - 249
02/01/2013 Authors: Esterberg ML; Ousley OY; Cubells JF; Walker EF
SUBTYPES OF MAJOR DEPRESSION IN SUBSTANCE DEPENDENCE
Volume: 36 Page(s): 48A - 48A
09/01/2012 Authors: Kranzler HR; Niciu M; Chan G; Gelernter J; Arias AJ; Douglas K; Weiss R; Anton RF; Farrer L; Cubells JF
Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial.
Trials Volume: 13 Page(s): 106
07/09/2012 Authors: Dunlop BW; Binder EB; Cubells JF; Goodman MM; Kelley ME; Kinkead B; Kutner M; Nemeroff CB; Newport DJ; Owens MJ
Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon--induced depression in patients with chronic hepatitis C.
Mol Psychiatry Volume: 17 Page(s): 781 - 789
07/01/2012 Authors: Smith AK; Simon JS; Gustafson EL; Noviello S; Cubells JF; Epstein MP; Devlin DJ; Qiu P; Albrecht JK; Brass CA
Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms.
Am J Med Genet B Neuropsychiatr Genet Volume: 159B Page(s): 549 - 559
07/01/2012 Authors: Hunter JE; Leslie M; Novak G; Hamilton D; Shubeck L; Charen K; Abramowitz A; Epstein MP; Lori A; Binder E
Pharmacogenetic association of the galanin receptor (GALR1) SNP rs2717162 with smoking cessation.
Neuropsychopharmacology Volume: 37 Page(s): 1683 - 1688
06/01/2012 Authors: Gold AB; Wileyto EP; Lori A; Conti D; Cubells JF; Lerman C
Regulation of mRNA expression encoding chaperone and co-chaperone proteins of the glucocorticoid receptor in peripheral blood: association with depressive symptoms during pregnancy.
Psychol Med Volume: 42 Page(s): 943 - 956
05/01/2012 Authors: Katz ER; Stowe ZN; Newport DJ; Kelley ME; Pace TW; Cubells JF; Binder EB
Prenatal antiepileptic exposure associates with neonatal DNA methylation differences.
Epigenetics Volume: 7 Page(s): 458 - 463
05/01/2012 Authors: Smith AK; Conneely KN; Newport DJ; Kilaru V; Schroeder JW; Pennell PB; Knight BT; Cubells JC; Stowe ZN; Brennan PA
DNA methylation in neonates born to women receiving psychiatric care.
Epigenetics Volume: 7 Page(s): 409 - 414
04/01/2012 Authors: Schroeder JW; Smith AK; Brennan PA; Conneely KN; Kilaru V; Knight BT; Newport DJ; Cubells JF; Stowe ZN
Human genetics of schizophrenia.
Volume: 106 Page(s): 37 - 52
01/01/2012 Authors: Claes S; Tang Y-L; Gillespie CF; Cubells JF
Genetics of stimulant dependence
Page(s): 306 - 315
01/01/2012 Authors: Cubells JF; Tang Y-L
Neonatal DNA methylation patterns associate with gestational age.
Epigenetics Volume: 6 Page(s): 1498 - 1504
12/01/2011 Authors: Schroeder JW; Conneely KN; Cubells JC; Kilaru V; Newport DJ; Knight BT; Stowe ZN; Brennan PA; Krushkal J; Tylavsky FA
Validation of the Autism Spectrum Screening Questionnaire, Mandarin Chinese Version (CH-ASSQ) in Beijing, China.
Autism Volume: 15 Page(s): 713 - 727
11/01/2011 Authors: Guo Y-Q; Tang Y; Rice C; Lee L-C; Wang Y-F; Cubells JF
Linkage analysis of plasma dopamine -hydroxylase activity in families of patients with schizophrenia.
Hum Genet Volume: 130 Page(s): 635 - 643
11/01/2011 Authors: Cubells JF; Sun X; Li W; Bonsall RW; McGrath JA; Avramopoulos D; Lasseter VK; Wolyniec PS; Tang Y-L; Mercer K
Dopamine -hydroxylase gene associates with stroop color-word task performance in Han Chinese children with attention deficit/hyperactivity disorder.
Am J Med Genet B Neuropsychiatr Genet Volume: 156B Page(s): 730 - 736
09/01/2011 Authors: Ji N; Shuai L; Chen Y; Liu L; Li H-M; Li Z-H; Yang L; Qian Q-J; Tang Y-L; Cubells JF
Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder.
Am J Med Genet B Neuropsychiatr Genet Volume: 156B Page(s): 700 - 708
09/01/2011 Authors: Smith AK; Conneely KN; Kilaru V; Mercer KB; Weiss TE; Bradley B; Tang Y; Gillespie CF; Cubells JF; Ressler KJ
Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.
Am J Med Genet B Neuropsychiatr Genet Volume: 156B Page(s): 651 - 660
09/01/2011 Authors: Ittiwut R; Listman JB; Ittiwut C; Cubells JF; Weiss RD; Brady K; Oslin D; Farrer LA; Kranzler HR; Gelernter J
Practical guidelines for managing patients with 22q11.2 deletion syndrome.
J Pediatr Volume: 159 Page(s): 332 - 9.e1
08/01/2011 Authors: Bassett AS; McDonald-McGinn DM; Devriendt K; Digilio MC; Goldenberg P; Habel A; Marino B; Oskarsdottir S; Philip N; Sullivan K
Predictors of neonatal hypothalamic-pituitary-adrenal axis activity at delivery.
Clin Endocrinol (Oxf) Volume: 75 Page(s): 90 - 95
07/01/2011 Authors: Smith AK; Newport DJ; Ashe MP; Brennan PA; Laprairie JL; Calamaras M; Nemeroff CB; Ritchie JC; Cubells JF; Stowe ZN
Prodromal symptoms in adolescents with 22q11.2 deletion syndrome and schizotypal personality disorder.
Schizophr Res Volume: 129 Page(s): 20 - 28
06/01/2011 Authors: Shapiro DI; Cubells JF; Ousley OY; Rockers K; Walker EF
The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment.
Neuropsychopharmacology Volume: 36 Page(s): 1412 - 1420
06/01/2011 Authors: Lori A; Tang Y; O'Malley S; Picciotto MR; Wu R; Conneely KN; Cubells JF
Functional polymorphisms of dopamine pathway genes (COMT, MAOB and DBH) in the development of Parkinson's disease: A study with multiple stratifications and risk factor adjustments
Volume: 26 Page(s): S319 - S319
05/01/2011 Authors: Xie T; Marder K; Tang Y; Levey A; Santella R; Tang M; Wang Q; Cubells J; Duan W; Clark L
Genotype-Controlled Analysis of Serum Dopamine beta-hydroxylase Across Pregnancy in Women Seeking Care for Mental illness
Volume: 69 Page(s): 59S - 60S
05/01/2011 Authors: Perdomo DL; Li W; Bonsall R; Tang Y; Newport J; Knight B; Stowe ZN; Cubells JF
Pharmaco-genetically guided treatment of recurrent rage outbursts in an adult male with 15q13.3 deletion syndrome.
Am J Med Genet A Volume: 155A Page(s): 805 - 810
04/01/2011 Authors: Cubells JF; Deoreo EH; Harvey PD; Garlow SJ; Garber K; Adam MP; Martin CL
Concerns over participant suicides prematurely abort a clinical trial of potentially significant impact on public health: how will we make progress in timid times?
Curr Psychiatry Rep Volume: 13 Page(s): 80 - 81
04/01/2011 Authors: Cubells JF
Copy number variants: a new molecular frontier in clinical psychiatry.
Curr Psychiatry Rep Volume: 13 Page(s): 129 - 137
04/01/2011 Authors: Moreno-De-Luca D; Cubells JF
A head-to-head comparison of risperidone and divalproex for treatment of pediatric bipolar disorder.
Curr Psychiatry Rep Volume: 13 Page(s): 82 - 83
04/01/2011 Authors: Cubells JF
Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients.
Drug Alcohol Depend Volume: 113 Page(s): 184 - 191
01/15/2011 Authors: Oliveto A; Poling J; Mancino MJ; Feldman Z; Cubells JF; Pruzinsky R; Gonsai K; Cargile C; Sofuoglu M; Chopra MP
Substance use disorders assessed using the Kreek-McHugh-Schluger-Kellogg (KMSK) scale in an urban low-income and predominantly African American sample of primary care patients.
Am J Addict Volume: 20 Page(s): 292 - 299
01/01/2011 Authors: Tang Y-L; Khoury L; Bradley B; Gillespie CF; Ressler KJ; Cubells JF
Genotype-controlled analysis of serum dopamine -hydroxylase activity in civilian post-traumatic stress disorder.
Prog Neuropsychopharmacol Biol Psychiatry Volume: 34 Page(s): 1396 - 1401
12/01/2010 Authors: Tang Y-L; Li W; Mercer K; Bradley B; Gillespie CF; Bonsall R; Ressler KJ; Cubells JF
Substance use, childhood traumatic experience, and Posttraumatic Stress Disorder in an urban civilian population.
Depress Anxiety Volume: 27 Page(s): 1077 - 1086
12/01/2010 Authors: Khoury L; Tang YL; Bradley B; Cubells JF; Ressler KJ
Social-adaptive and psychological functioning of patients affected by Fabry disease.
J Inherit Metab Dis Volume: 33 Suppl 3 Page(s): S73 - S81
12/01/2010 Authors: Laney DA; Gruskin DJ; Fernhoff PM; Cubells JF; Ousley OY; Hipp H; Mehta AJ
Catechol-O-methyltransferase modulation of cortisol secretion in psychiatrically at-risk and healthy adolescents.
Psychiatr Genet Volume: 20 Page(s): 166 - 170
08/01/2010 Authors: Walder DJ; Trotman HD; Cubells JF; Brasfield J; Tang Y-L; Walker EF
A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at-risk psychiatric cohort.
J Psychiatr Res Volume: 44 Page(s): 640 - 646
07/01/2010 Authors: Binder EB; Newport DJ; Zach EB; Smith AK; Deveau TC; Altshuler LL; Cohen LS; Stowe ZN; Cubells JF
The Galanin Receptor 1 (GalR1) Gene Associates with Tobacco Craving in Smokers Seeking Treatment Cessation Therapy
Volume: 67 Page(s): 191S - 191S
05/01/2010 Authors: Lori A; Tang Y-L; O'Malley SS; Picciotto MR; Wu R; Cubells JF
Association of Plasma Dopamine beta-Hydroxylase and Variants at the DBH Gene with Differences in Factor Scores Representing Clinical Features of Schizophrenia
Volume: 67 Page(s): 162S - 162S
05/01/2010 Authors: Cubells JF; Sun X; McGrath JA; Elston RC; Li W; Bonsall RW; Tang Y-L; Avramopoulos D; Lasseter VK; Wolyniec P
Validation of the Kreek-McHugh-Schluger-Kellogg (KMSK) Scale of Substance Use in an Urban Low-Income and Predominantly African-American Sample of Primary Care Patients
Volume: 67 Page(s): 91S - 91S
05/01/2010 Authors: Tang Y; Khoury L; Bradley B; Gillespie C; Ressler KJ; Cubells JF
Validation of the Autism Spectrum Screening Scale (ASSQ), Mandarin Chinese Version
Volume: 67 Page(s): 219S - 219S
05/01/2010 Authors: Guo Y; Tang Y; Rice C; Lee L-C; Wang Y; Cubells JF
FKBP5 Polymorphism and Childhood Trauma are Associated with Impaired Fear Inhibition
Volume: 67 Page(s): 114S - 114S
05/01/2010 Authors: Jovanovic T; Norrholm SD; Binder E; Cubells J; Mercer K; Duncan E; Davis M; Bradley B; Ressler K
Association between DNA Methylation Patterns and Total Life Stress in Inner City Primary Care Patients
Volume: 67 Page(s): 147S - 147S
05/01/2010 Authors: Smith AK; Kilaru V; Conneely KN; Gillespie CF; Mercer KB; Weiss TE; Bradley-Davino B; Tang Y; Cubells JF; Ressler KJ
Genotype-Controlled Analysis of Plasma Dopamine beta-Hydroxylase Activity in Civilian Post-Traumatic Stress Disorder
Volume: 67 Page(s): 115S - 115S
05/01/2010 Authors: Tang Y; Li W; Mercer K; Bradley B; Gillespie CF; Bonsall R; Ressler K; Cubells JF
Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms.
Am J Med Genet B Neuropsychiatr Genet Volume: 153B Page(s): 812 - 824
04/05/2010 Authors: Ressler KJ; Bradley B; Mercer KB; Deveau TC; Smith AK; Gillespie CF; Nemeroff CB; Cubells JF; Binder EB
SCHIZOTYPAL PERSONALITY DISORDER AND THE 22Q11.2 DELETION SYNDROME: THE RELATIONSHIP BETWEEN PRODROMAL SYMPTOMS AND AUTISTIC FEATURES
Volume: 117 Page(s): 303 - 303
04/01/2010 Authors: Esterberg ML; Ousley O; Cubells J; Walker EF
COGNITIVE PERFORMANCE IN THE SCHIZOPHRENIA SPECTRUM: THE INFLUENCE OF COMT AND BDNF POLYMORPHISMS
Volume: 117 Page(s): 455 - 455
04/01/2010 Authors: Trotman HD; Cubells JF; Compton MT; Walker EF
Functional Polymorphisms of Human Dopamine Pathway Genes COMT, DBH and MAOS: A Pilot SNP Study of Single Gene Locus and Gene-Gene Interaction in Parkinson Disease
Volume: 74 Page(s): A254 - A254
03/02/2010 Authors: Xie T; Levey A; Tang Y; Cubells J; Duan W
Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment.
Mol Psychiatry Volume: 14 Page(s): 1095 - 1104
12/01/2009 Authors: Bull SJ; Huezo-Diaz P; Binder EB; Cubells JF; Ranjith G; Maddock C; Miyazaki C; Alexander N; Hotopf M; Cleare AJ
Subtypes of major depression in substance dependence.
Addiction Volume: 104 Page(s): 1700 - 1709
10/01/2009 Authors: Niciu MJ; Chan G; Gelernter J; Arias AJ; Douglas K; Weiss R; Anton RF; Farrer L; Cubells JF; Kranzler HR
Performance on the Modified Card Sorting Test and its relation to psychopathology in adolescents and young adults with 22q11.2 deletion syndrome.
J Intellect Disabil Res Volume: 53 Page(s): 665 - 676
07/01/2009 Authors: Rockers K; Ousley O; Sutton T; Schoenberg E; Coleman K; Walker E; Cubells JF
Sources of unreliability in the diagnosis of substance dependence.
J Stud Alcohol Drugs Volume: 70 Page(s): 475 - 481
05/01/2009 Authors: Feinn R; Gelernter J; Cubells JF; Farrer L; Kranzler HR
Polymorphisms in CRHR1 Moderate the Effects of 5-HTTLPR x Child Abuse Interactions On Adult Depression
Volume: 65 Page(s): 227S - 227S
04/15/2009 Authors: Ressler KJ; Bradley B; Gillespie CF; Cubells J; Nemeroff CB; Binder E
Linkage Analysis of Plasma Dopamine beta-Hydroxylase in Families Segregating Schizophrenia
Volume: 65 Page(s): 197S - 197S
04/15/2009 Authors: Cubells JF; Sun X; Elston RC; Bonsall RW; Mercer K; Li W; Tang Y-L; Avramopoulos D; Lasseter VK; Wolniek PS
Trauma Exposure and Stress-Related Disorders in Inner City Primary Care Patients
Volume: 65 Page(s): 118S - 118S
04/15/2009 Authors: Gillespie CF; Bradley RG; Mercer K; Smith AK; Conneely K; Gapen M; Weiss T; Schwartz AC; Cubells JF; Ressler KJ
22Q11DELETION SYNDROME AND SCHIZOTYPAL PERSONALITY DISORDER: BEHAVIORAL AND PRODROMAL SYMPTOMS IN INDIVIDUALS AT HIGH RISK FOR PSYCHOSIS
Volume: 35 Page(s): 20 - 21
03/01/2009 Authors: Shapiro D; Cubells JF; Rockers K; Ousley O; Walker EF
Association of variants in MANEA with cocaine-related behaviors.
Arch Gen Psychiatry Volume: 66 Page(s): 267 - 274
03/01/2009 Authors: Farrer LA; Kranzler HR; Yu Y; Weiss RD; Brady KT; Anton R; Cubells JF; Gelernter J
Trauma exposure and stress-related disorders in inner city primary care patients.
Gen Hosp Psychiatry Volume: 31 Page(s): 505 - 514
01/01/2009 Authors: Gillespie CF; Bradley B; Mercer K; Smith AK; Conneely K; Gapen M; Weiss T; Schwartz AC; Cubells JF; Ressler KJ
Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP).
Am J Addict Volume: 18 Page(s): 339 - 345
01/01/2009 Authors: Tang Y-L; Kranzler HR; Gelernter J; Farrer LA; Pearson D; Cubells JF
Genetics and Genomics
Page(s): 81 - 104
01/01/2009 Authors: Binder EB; Cubells JF
Gender dependent differences in glucocorticoid receptor sensitivity and mRNA levels of glucocorticoid receptor co-chaperone proteins in college-aged meditators
Volume: 11 Page(s): 220 - 220
07/01/2008 Authors: Katz E; Binder EB; Cubells JF; Pace TWW; Raison CL
Childhood trauma alters the expression of the glucocorticoid receptor co-chaperone BAG1
Volume: 11 Page(s): 287 - 288
07/01/2008 Authors: Deveau T; Heim C; Mletzko T; Cubells JF; Nemeroff C; Binder EB
Genetic association analysis of dopamine-related genes with cocaine-induced psychosis
Volume: 106 Page(s): 34 - 34
07/01/2008 Authors: Tang Y; Binder EB; Kranzler HR; Gelernter J; Houston M; Caceda R; Kinkead B; Nemeroff CB; Cubells JF
Abnormal lipid metabolism in patients with PTSD identified in a general medical clinic
Volume: 63 Page(s): 179S - 179S
04/01/2008 Authors: Weiss TE; Gillespie CF; Jones H; Schwartz A; Woodworth M; Umpierrez G; Cubells JF; Bradley RG; Ressler KJ
Motor-behavior abnormalities and schizophrenia-prodrome symptoms in adolescents and young adults with 22q11 deletion syndrome
Volume: 63 Page(s): 269S - 269S
04/01/2008 Authors: Cubells JF; Ousley OY; Rockers K; McMillan A; Schoenberg E; Sutton TJ; Kim S-H; Coleman K; Walker EF
Risk for adult posttraumatic stress disorder is predicted by child abuse and FKBP5, a gene regulating stress-responsiveness
Volume: 63 Page(s): 174S - 174S
04/01/2008 Authors: Gillespie CF; Bradley RG; Liu W; Epstein MR; Deveau TC; Tang Y; Heim CM; Nemeroff CB; Schwartz AC; Cubells JF
A single nucleotide polymorphism (SNP) at DBH is associated with Alzheimer disease in European-American subjects
Volume: 63 Page(s): 92S - 92S
04/01/2008 Authors: Tang Y; Lah J; Rosen A; Levey A; Cubells JF
Predictors of neonatal hypothalamic-pituitary-adrenal axis activity at delivery in women with psychiatric illness
Volume: 63 Page(s): 231S - 231S
04/01/2008 Authors: Smith AK; Katz ER; Newport DJ; Brennan PA; Ritchie JC; Ashe MR; Nemeroff CB; Cubells JF; Stowe ZN
Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.
JAMA Volume: 299 Page(s): 1291 - 1305
03/19/2008 Authors: Binder EB; Bradley RG; Liu W; Epstein MP; Deveau TC; Mercer KB; Tang Y; Gillespie CF; Heim CM; Nemeroff CB
Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.
Arch Gen Psychiatry Volume: 65 Page(s): 190 - 200
02/01/2008 Authors: Bradley RG; Binder EB; Epstein MP; Tang Y; Nair HP; Liu W; Gillespie CF; Berg T; Evces M; Newport DJ
Sleep & activity disturbances in 22q11 Deletion Syndrome using actigraphy
Volume: 31 Page(s): A70 - A70
01/01/2008 Authors: Umlauf MG; Coleman K; Rockers K; Cubells JF; Ousley O; Pryor ER; Makris C
Addictions biology: haplotype-based analysis for 130 candidate genes on a single array.
Alcohol Alcohol Volume: 43 Page(s): 505 - 515
01/01/2008 Authors: Hodgkinson CA; Yuan Q; Xu K; Shen P-H; Heinz E; Lobos EA; Binder EB; Cubells J; Ehlers CL; Gelernter J
Dopamine beta-hydroxylase (DBH) activity and -1021C/T polymorphism of DBH gene in combat-related post-traumatic stress disorder.
Am J Med Genet B Neuropsychiatr Genet Volume: 144B Page(s): 1087 - 1089
12/05/2007 Authors: Mustapi M; Pivac N; Kozari-Kovaci D; Dezeljin M; Cubells JF; Mck-Seler D
The incidence of depression and anxiety is increased in patients affected by Fabry disease
Volume: 92 Page(s): S25 - S26
12/01/2007 Authors: Gruskin D; Laney D; Cubells J
Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA).
Drug Alcohol Depend Volume: 91 Page(s): 85 - 90
11/02/2007 Authors: Pierucci-Lagha A; Gelernter J; Chan G; Arias A; Cubells JF; Farrer L; Kranzler HR
Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African Americans.
Eur J Hum Genet Volume: 15 Page(s): 878 - 883
08/01/2007 Authors: Tang Y-L; Epstein MP; Anderson GM; Zabetian CP; Cubells JF
Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration.
Biol Psychiatry Volume: 61 Page(s): 1310 - 1313
06/01/2007 Authors: Kalayasiri R; Sughondhabirom A; Gueorguieva R; Coric V; Lynch WJ; Lappalainen J; Gelernter J; Cubells JF; Malison RT
MRNA levels of BCL2-associated athanogene (BAG1) change during pregnancy and may be associated with glucocorticoid receptor (GR) sensitivity in a high-risk population for periparturn depression
Volume: 61 Page(s): 6S - 6S
04/15/2007 Authors: Katz ER; Deveau TC; Newport DJ; Stowe ZN; Cubells JF; Binder EB
Linkage disequilibrium (LD) structure of the cholecystolkinin-B receptor gene (CCKBR) in European-American (EA) and African-American (AA) subjects
Volume: 61 Page(s): 206S - 206S
04/15/2007 Authors: Gillespie CF; Binder ES; Tang Y; Berg T; Liu W; Bradley RG; Ressler KJ; Cubells JF
Genetic variants in genes regulating the corticotropin releasing hormone (CRH) system and response to citalopram in the STAR*D sample
Volume: 61 Page(s): 172S - 172S
04/15/2007 Authors: Binder EB; Owens MJ; Liu W; Fava M; Rush AJ; Trivedi MH; Cubells JF; Nemeroff CB
Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects
Volume: 61 Page(s): 46S - 46S
04/15/2007 Authors: Tang Y-L; Kranzler HR; Gelernter J; Farrer LA; Cubells JF
Comorbid alcohol dependence is associated with increased severity of cocaine-induced psychosis: Results from 243 cocaine dependent subjects
Volume: 61 Page(s): 46S - 46S
04/15/2007 Authors: Tang Y; Kranzler HR; Gelernter J; Cubells JF
Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African Americans
Volume: 61 Page(s): 135S - 135S
04/15/2007 Authors: Tang Y; Anderson GM; Zabetian CR; Cubells JF
Novel promoter variant in the neurotensin gene is protective against cocaine-induced psychosis in African American subjects
Volume: 61 Page(s): 205S - 205S
04/15/2007 Authors: Binder EB; Houston MJ; Caseda R; Tang Y-L; Kinkead B; Deveau TC; Gelernter J; Kranzler HR; Nemeroff CB; Cubells JF
A review of neurocognitive and behavioral profiles associated with 22q11 deletion syndrome: implications for clinical evaluation and treatment.
Curr Psychiatry Rep Volume: 9 Page(s): 148 - 158
04/01/2007 Authors: Ousley O; Rockers K; Dell ML; Coleman K; Cubells JF
Clinical genomic psychiatry comes of age in the evaluation and treatment of developmental disabilities: is our nation prepared to make the benefits available to all who need them?
Curr Psychiatry Rep Volume: 9 Page(s): 81 - 82
04/01/2007 Authors: Cubells JF
Acetylcholine and cognition in schizophrenia: effects of galantamine.
Curr Psychiatry Rep Volume: 9 Page(s): 133 - 134
04/01/2007 Authors: Cubells JF
Beyond irritability and aggressive behavior: does risperidone improve adaptive behavior in autistic spectrum disorders?
Curr Psychiatry Rep Volume: 9 Page(s): 132 - 133
04/01/2007 Authors: Cubells JF
Targeting the glutamate system in the treatment of autistic spectrum disorders.
Curr Psychiatry Rep Volume: 9 Page(s): 131
04/01/2007 Authors: Cubells JF
Genetic research and smoking behavior.
JAMA Volume: 297 Page(s): 809
02/28/2007 Authors: Bierut LJ; Cubells JF; Iacono WG; Li MD; Madden PAF; Nelson EC; Pollock JD; Rutter JL; Swan GE; Vanyukov M
Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects.
Am J Addict Volume: 16 Page(s): 343 - 351
01/01/2007 Authors: Tang Y-L; Kranzler HR; Gelernter J; Farrer LA; Cubells JF
Lack of physiological regulation of the expression of co-chaperones of the glucocorticoid receptor in periparturn depression
Volume: 31 Page(s): S135 - S135
12/01/2006 Authors: Katz ER; Deveau TC; Capello CF; Owens MJ; Newport DJ; Stowe ZN; Cubells JF; Binder EB
A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine beta-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide polymorphisms.
Biol Psychiatry Volume: 60 Page(s): 1034 - 1038
11/15/2006 Authors: Tang Y; Buxbaum SG; Waldman I; Anderson GM; Zabetian CP; Khnke MD; Cubells JF
Autism-spectrum and schizophrenia-prodrome symptoms in young adults with 22q11 Deletion Syndrome
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH Volume: 50 Page(s): 785 - 785
11/01/2006 Authors: Ousely OY; Rockers K; Walker E; Coleman K; Cubells JF
Co-chaperones of the glucocorticoid receptor and depression during pregnancy
Volume: 141B Page(s): 710 - 711
10/05/2006 Authors: Katz E; Binder E; Deveau T; Newport J; Stowe Z; Cubells J; Nemeroff C
Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence.
Am J Med Genet B Neuropsychiatr Genet Volume: 141B Page(s): 499 - 503
07/05/2006 Authors: Herman AI; Kranzler HR; Cubells JF; Gelernter J; Covault J
Co-chaperones of the glucocorticoid receptor and peripartum depression
Volume: 9 Page(s): S178 - S178
07/01/2006 Authors: Binder E; Deveau T; Katz E; Newport J; Stowe Z; Cubells J
Opiate addiction in China: current situation and treatments.
Addiction Volume: 101 Page(s): 657 - 665
05/01/2006 Authors: Tang Y-L; Zhao D; Zhao C; Cubells JF
Association of polymorphism in the neurotensin/neuromedin N preproprotein (NTS) gene with cocaine-induced psychosis
Volume: 59 Page(s): 54S - 54S
04/15/2006 Authors: Binder EB; Tang YL; Gelernter J; Kranzler HR; Nemeroff CB; Cubells JF
Alleles and a haplotype at DRD3 associate with cocaine-induced psychosis in African-American cocaine-dependent subjects
Volume: 59 Page(s): 138S - 138S
04/15/2006 Authors: Tang YL; Binder EB; Gelernter J; Kranzler HR; Cubells JF
A cannabinoid-1 receptor antagonist to treat obesity.
Curr Psychiatry Rep Volume: 8 Page(s): 129 - 130
04/01/2006 Authors: Cubells JF
Disulfiram for cocaine dependence.
Curr Psychiatry Rep Volume: 8 Page(s): 131 - 132
04/01/2006 Authors: Cubells JF
Topiramate for cocaine dependence.
Curr Psychiatry Rep Volume: 8 Page(s): 130 - 131
04/01/2006 Authors: Cubells JF
High-resolution mapping of DNA copy alterations in human chromosome 22 using high-density tiling oligonucleotide arrays.
Proc Natl Acad Sci U S A Volume: 103 Page(s): 4534 - 4539
03/21/2006 Authors: Urban AE; Korbel JO; Selzer R; Richmond T; Hacker A; Popescu GV; Cubells JF; Green R; Emanuel BS; Gerstein MB
Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence.
Addict Biol Volume: 11 Page(s): 76 - 83
03/01/2006 Authors: Dahl JP; Cubells JF; Ray R; Weller AE; Lohoff FW; Ferraro TN; Oslin DW; Kampman KM; Dackis C; Tang Y
Self-reported paranoia during laboratory "binge" cocaine self-administration in humans.
Pharmacol Biochem Behav Volume: 83 Page(s): 249 - 256
02/01/2006 Authors: Kalayasiri R; Sughondhabirom A; Gueorguieva R; Coric V; Lynch WJ; Morgan PT; Cubells JF; Malison RT
Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA).
Drug Alcohol Depend Volume: 80 Page(s): 303 - 312
12/12/2005 Authors: Pierucci-Lagha A; Gelernter J; Feinn R; Cubells JF; Pearson D; Pollastri A; Farrer L; Kranzler HR
Human genetics of plasma DBH activity in cocaine dependence
Volume: 30 Page(s): S1 - S1
12/01/2005 Authors: Cubells JF; Schottenfeld RS; Oliveto A; George T; Chawarski MC; Poling J; Kranzler HR; Gelernter J; Kosten TR
Neurotensin system genes and susceptibility to cocaine-induced psychosis
Volume: 30 Page(s): S87 - S87
12/01/2005 Authors: Binder EB; Tang Y; Nemeroff CB; Cubells JF
Haplotype-controlled analysis of the association of a non-synonymous single nucleotide polymorphism at DBH (+ 1603C --> T) with plasma dopamine beta-hydroxylase activity.
Am J Med Genet B Neuropsychiatr Genet Volume: 139B Page(s): 88 - 90
11/05/2005 Authors: Tang Y; Anderson GM; Zabetian CP; Khnke MD; Cubells JF
Genetic research on nicotine dependence will facilitate public health.
PLoS Med Volume: 2 Page(s): e396
11/01/2005 Authors: Cubells J
Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP).
Drug Alcohol Depend Volume: 80 Page(s): 23 - 33
10/01/2005 Authors: Cubells JF; Feinn R; Pearson D; Burda J; Tang Y; Farrer LA; Gelernter J; Kranzler HR
Dopamine B-hydroxylase and psychotic depression
Volume: 138B Page(s): 105 - 106
09/05/2005 Authors: Katz ER; Westby K; Price LH; Meyers BS; Anderson GM; Gelernter J; Cubells JF
Allele and haplotype frequencies of an addiction candidate gene, CNR1, in African Americans and European Americans with cocaine dependence
Volume: 138B Page(s): 38 - 38
09/05/2005 Authors: Tang Y; Kranzler HR; Gelernter J; Cubells JF
Application of ultra-high resolution fine-tiling array CGH (FT-CGH) to the analysis of 22q11 deletion syndrome
Volume: 138B Page(s): 138 - 138
09/05/2005 Authors: Urban A; Selzer R; Richmond T; Popescu G; Cubells JF; Green R; Emanuel B; Weissman SM; Snyder M
Association analysis of dopamine beta-hydroxylase gene and attention deficit hyperactivity disorder in the Chinese Han population
Volume: 138B Page(s): 63 - 63
09/05/2005 Authors: Zhang F; Wang Y; Li J; Wang L; Wang B; Cubells J; Tang Y; Sham P
Association study between three polymorphisms of MAOA gene and attention deficit hyperactivity disorder among the Chinese Han ethnicity
Volume: 138B Page(s): 63 - 64
09/05/2005 Authors: Zhang H; Wang Y; Li J; Yang L; Wang B; Cubells J; Tang Y; Sham P
CB1 receptor gene CN1 and drug dependence: Replication of association with a 3-marker intron 2 haplotype in both Caucasian and African-American samples
Volume: 138B Page(s): 34 - 34
09/05/2005 Authors: Covault J; Herman A; Gelernter J; Cubells J; Kranzler H
Association of norepinephrine transporter gene and monoamine oxidase A gene with methylphenidate response
Volume: 138B Page(s): 63 - 63
09/05/2005 Authors: Yang L; Wang Y; Tang Y; Wang B; Cubells JF; Faraone SV
Rapid array-based genomic characterization of a subtle structural abnormality: a patient with psychosis and der(18)t(5;18)(p14.1;p11.23).
Am J Med Genet A Volume: 134 Page(s): 282 - 289
04/30/2005 Authors: Drazinic CM; Ercan-Sencicek AG; Gault LM; Hisama FM; Qumsiyeh MB; Nowak NJ; Cubells JF; State MW
Rapid genomic array analysis of copy number abnormalities in a patient with psychosis and der(18)t(18;?) (p12;?)
Volume: 29 Page(s): S114 - S114
12/01/2004 Authors: Drazinic C; Ercan-Sencicek AG; Gault L; Hisama F; Nowak NJ; Qumsiyeh M; Cubells J; State MW
Efficacy of disulfiram for cocaine abuse in methadone patients: Relevance of dopamine beta-hydroxylase
Volume: 29 Page(s): S184 - S184
12/01/2004 Authors: Oliveto A; Poling J; Pruzinsky R; Gonsai K; Cubells J; Anderson G; Sofuoglu M; Carroll K; Gonzalez G; Kosten TR
DBH genotype in disulfiram treatment for cocaine dependence
Volume: 29 Page(s): S72 - S72
12/01/2004 Authors: Cubells JF; Chawarski MC; George TP; Schottenfeld RS
DBH genotype in disulfiram treatment for cocaine dependence
Volume: 130B Page(s): 164 - 165
09/15/2004 Authors: Cubells JF; Chawarski MC; George T; Schottenfled RS
Application of emerging genomics and epigenomics technologies to the analysis of 22q11 deletion syndrome
Volume: 130B Page(s): 148 - 149
09/15/2004 Authors: Urban AE; Pan X; Tang Y; Lian J; Szekely A; Lian Z; Euskirchen G; Nelson K; Goetsch-Martone R; Rinn J
Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology.
Psychopharmacology (Berl) Volume: 174 Page(s): 463 - 476
08/01/2004 Authors: Cubells JF; Zabetian CP
Sex differences in cocaine-dependent individuals' response to disulfiram treatment.
Addict Behav Volume: 29 Page(s): 1123 - 1128
08/01/2004 Authors: Nich C; McCance-Katz EF; Petrakis IL; Cubells JF; Rounsaville BJ; Carroll KM
Setting priorities for genomic research.
Science Volume: 304 Page(s): 1445 - 1447
06/04/2004 Authors: Berrettini W; Bierut L; Crowley TJ; Cubells JF; Frascella J; Gelernter J; Hewitt JK; Kreek MJ; Lachman H; Leppert M
A revised allele frequency estimate and haplotype analysis of the DBH deficiency mutation IVS1+2T --> C in African- and European-Americans.
Am J Med Genet A Volume: 123A Page(s): 190 - 192
12/01/2003 Authors: Zabetian CP; Romero R; Robertson D; Sharma S; Padbury JF; Kuivaniemi H; Kim K-S; Kim C-H; Khnke MD; Kranzler HR
Association of a DBH intron 5 Taq I polymorphism and plasma dopamine beta-hydroxylase activity results from linkage disequilibrium to a putative functional variant, -1021C-> T.
Volume: 73 Page(s): 388 - 388
11/01/2003 Authors: Tang Y; Buxbaum S; Kohnke M; Anderson G; Cubells J
Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophy.
Am J Med Genet A Volume: 120A Page(s): 234 - 236
07/15/2003 Authors: Cho S; Kim C-H; Cubells JF; Zabetian CP; Hwang D-Y; Kim J-W; Cohen BM; Biaggioni I; Robertson D; Kim K-S
The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine beta-hydroxylase activity.
Am J Hum Genet Volume: 72 Page(s): 1389 - 1400
06/01/2003 Authors: Zabetian CP; Buxbaum SG; Elston RC; Khnke MD; Anderson GM; Gelernter J; Cubells JF
Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study.
Am J Med Genet B Neuropsychiatr Genet Volume: 117B Page(s): 33 - 38
02/01/2003 Authors: Yamamoto K; Cubells JF; Gelernter J; Benkelfat C; Lalonde P; Bloom D; Lal S; Labelle A; Turecki G; Rouleau GA
A genotype-controlled analysis of plasma dopamine beta-hydroxylase in healthy and alcoholic subjects: evidence for alcohol-related differences in noradrenergic function.
Biol Psychiatry Volume: 52 Page(s): 1151 - 1158
12/15/2002 Authors: Khnke MD; Zabetian CP; Anderson GM; Kolb W; Gaertner I; Buchkremer G; Vonthein R; Schick S; Lutz U; Khnke AM
Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary data.
Biol Psychiatry Volume: 51 Page(s): 683 - 686
04/15/2002 Authors: Boutros NN; Gelernter J; Gooding DC; Cubells J; Young A; Krystal JH; Kosten T
Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency.
Am J Med Genet Volume: 108 Page(s): 140 - 147
03/01/2002 Authors: Kim C-H; Zabetian CP; Cubells JF; Cho S; Biaggioni I; Cohen BM; Robertson D; Kim K-S
Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression.
Biol Psychiatry Volume: 51 Page(s): 358 - 364
03/01/2002 Authors: Cubells JF; Price LH; Meyers BS; Anderson GM; Zabetian CP; Alexopoulos GS; Nelson JC; Sanacora G; Kirwin P; Carpenter L
Molecular genetic analysis of plasma dopamine beta-hydroxylase in depression - New implications for an old biomarker
Volume: 53 Page(s): 423 - 426
01/01/2002 Authors: Cubells JF; Zabetian CP; Anderson GM; Price LH; Meyers BS; Malison RT; Nelson JC; Nagatsu T; Ichinose H; Gelernter J
Bright light therapy for schizoaffective disorder.
Am J Psychiatry Volume: 158 Page(s): 2086 - 2087
12/01/2001 Authors: Oren DA; Cubells JF; Litsch S
The dopamine beta-hydroxylase C-1021T polymorphism: Evolutionary origins and relationship to plasma DBH activity in nonhuman primates.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 69 Page(s): 396 - 396
10/01/2001 Authors: Zabetian CP; Anderson GM; Hoppenot R; Kaplan JR; Cubells JF
A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus.
Am J Hum Genet Volume: 68 Page(s): 515 - 522
02/01/2001 Authors: Zabetian CP; Anderson GM; Buxbaum SG; Elston RC; Ichinose H; Nagatsu T; Kim KS; Kim CH; Malison RT; Gelernter J
Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence.
Am J Med Genet Volume: 96 Page(s): 638 - 645
10/09/2000 Authors: Zabetian CP; Gelernter J; Cubells JF
Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in unipolar psychotic depression.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 67 Page(s): 339 - 339
10/01/2000 Authors: Cubells JF; Price LH; Meyers B; Anderson GM; Zabetian CP; Malison RT; Alexopoulos G; Sanacora G; Nelson JC; Kirwin P
Molecular genetics of the human very-low dopamine beta-hydroxylase (DBH) trait.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 67 Page(s): 179 - 179
10/01/2000 Authors: Zabetian CP; Anderson GM; Gelernter J; Ichinose H; Nagatsu T; Malison RT; Cubells JF
Phenotypic assessment of cocaine-induced paranoia and psychotic symptoms (CIPPS)
BIOLOGICAL PSYCHIATRY Volume: 47 Page(s): 167S - 168S
04/15/2000 Authors: Cubells JF; McCance-Katz EF; Grieg T; Hart R; Coporale MJ; Malison RT; Gelernter J; Bell MD
Functional variants at CYP2A6: New genotyping methods, population genetics, and relevance to studies of tobacco dependence
BIOLOGICAL PSYCHIATRY Volume: 47 Page(s): 132S - 133S
04/15/2000 Authors: Zabetian CP; Gelernter J; Cubells JF
A haplotype at the DBH locus, associated with low plasma dopamine beta-hydroxylase activity, also associates with cocaine-induced paranoia.
Mol Psychiatry Volume: 5 Page(s): 56 - 63
01/01/2000 Authors: Cubells JF; Kranzler HR; McCance-Katz E; Anderson GM; Malison RT; Price LH; Gelernter J
A low enzyme activity haplotype at DBH associates with cocaine-induced paranoia.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 65 Page(s): A268 - A268
10/01/1999 Authors: Cubells JF; Kranzler HR; McCance-Katz E; Anderson GM; Malison RT; Price LH; Gelernter J
Cytochrome P450 2A6 (CYP2A6): a population genetics study using a new genotyping approach.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 65 Page(s): A433 - A433
10/01/1999 Authors: Zabetian CP; Gelernter J; Kranzler HR; Cubells JF
Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects.
Mol Psychiatry Volume: 4 Page(s): 476 - 483
09/01/1999 Authors: Gelernter J; Kranzler H; Cubells J
Genetic variation at the DBH locus: Relationship to biochemical and psychiatric phenotype
BIOLOGICAL PSYCHIATRY Volume: 45 Page(s): 51S - 51S
04/15/1999 Authors: Cubells JF; Kranzler H; McCance-Katz E; Satel S; Gelernter J
Candidate gene studies in substance dependence
BIOLOGICAL PSYCHIATRY Volume: 45 Page(s): 101S - 101S
04/15/1999 Authors: Gelernter J; Kranzler H; Cubells J
A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene.
J Biol Chem Volume: 274 Page(s): 6507 - 6518
03/05/1999 Authors: Kim CH; Kim HS; Cubells JF; Kim KS
Population studies of polymorphisms of the serotonin transporter protein gene.
Am J Med Genet Volume: 88 Page(s): 61 - 66
02/05/1999 Authors: Gelernter J; Cubells JF; Kidd JR; Pakstis AJ; Kidd KK
DRD2 allele frequencies and linkage disequilibria, including the -141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects.
Genomics Volume: 51 Page(s): 21 - 26
07/01/1998 Authors: Gelernter J; Kranzler H; Cubells JF; Ichinose H; Nagatsu T
Dopamine beta-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation.
Hum Genet Volume: 102 Page(s): 533 - 540
05/01/1998 Authors: Cubells JF; van Kammen DP; Kelley ME; Anderson GM; O'Connor DT; Price LH; Malison R; Rao PA; Kobayashi K; Nagatsu T
Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects.
Hum Genet Volume: 101 Page(s): 243 - 246
12/01/1997 Authors: Gelernter J; Kranzler H; Cubells JF
Association between DBH alleles and dopamine beta-hydroxylase biochemical phenotypes in subjects with schizophrenia, and mood or anxiety disorders.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 61 Page(s): A272 - A272
10/01/1997 Authors: Cubells JF; van Kammen DP; Kelley ME; Price LH; Anderson GM; Malison R; Rao P; O'Connor DT; Gelernter J
Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's disease.
Am J Med Genet Volume: 74 Page(s): 497 - 500
09/19/1997 Authors: Gelernter J; Van Dyck C; van Kammen DP; Malison R; Price LH; Cubells JF; Berman R; Charney DS; Heninger G
Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH).
Am J Med Genet Volume: 74 Page(s): 374 - 379
07/25/1997 Authors: Cubells JF; Kobayashi K; Nagatsu T; Kidd KK; Kidd JR; Calafell F; Kranzler HR; Ichinose H; Gelernter J
Inducible cAMP early repressor can modulate tyrosine hydroxylase gene expression after stimulation of cAMP synthesis.
J Biol Chem Volume: 271 Page(s): 25375 - 25381
10/11/1996 Authors: Tinti C; Conti B; Cubells JF; Kim KS; Baker H; Joh TH
A transgenic mouse model to study transsynaptic regulation of tyrosine hydroxylase gene expression.
J Neurochem Volume: 67 Page(s): 11 - 18
07/01/1996 Authors: Min N; Joh TH; Corp ES; Baker H; Cubells JF; Son JH
Differential in vivo regulation of mRNA encoding the norepinephrine transporter and tyrosine hydroxylase in rat adrenal medulla and locus ceruleus.
J Neurochem Volume: 65 Page(s): 502 - 509
08/01/1995 Authors: Cubells JF; Kim KS; Baker H; Volpe BT; Chung Y; Houpt TA; Wessel TC; Joh TH
Innervation-independent changes in the mRNAs encoding tyrosine hydroxylase and the norepinephrine transporter in rat adrenal medulla after high-dose reserpine.
Neurosci Lett Volume: 193 Page(s): 189 - 192
07/07/1995 Authors: Cubells JF; Baker H; Volpe BT; Smith GP; Das SS; Joh TH
Cyclic AMP-dependent protein kinase regulates basal and cyclic AMP-stimulated but not phorbol ester-stimulated transcription of the tyrosine hydroxylase gene.
J Neurochem Volume: 63 Page(s): 834 - 842
09/01/1994 Authors: Kim KS; Tinti C; Song B; Cubells JF; Joh TH
Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress.
J Neurosci Volume: 14 Page(s): 2260 - 2271
04/01/1994 Authors: Cubells JF; Rayport S; Rajendran G; Sulzer D
2-amino-4-phosphonobutyric acid exerts a light-dependent effect on post-gabaculine levels of retinal gamma-aminobutyric acid (GABA): evidence that ON synaptic pathways regulate retinal GABAergic transmission.
J Neurochem Volume: 57 Page(s): 46 - 52
07/01/1991 Authors: Cubells JF; Ndubuka C; Makman MH
REGULATION BY NEUROPEPTIDES OF AMINO-ACID TRANSMITTER RELEASE IN MAMMALIAN BRAIN AND RETINA
Volume: 11 Page(s): 271 - 286
01/01/1991 Authors: MAKMAN MH; CUBELLS JF
The effects of gabaculine in vivo on the distribution of GABA-like immunoreactivity in the rat retina.
Brain Res Volume: 458 Page(s): 82 - 90
08/16/1988 Authors: Cubells JF; Walkley SU; Makman MH
The effects of in vivo inactivation of GABA-transaminase and glutamic acid decarboxylase on levels of GABA in the rat retina.
Brain Res Volume: 419 Page(s): 208 - 215
09/01/1987 Authors: Cubells JF; Blanchard JS; Makman MH
In vivo action of enzyme-activated irreversible inhibitors of glutamic acid decarboxylase and gamma-aminobutyric acid transaminase in retina vs. brain.
J Pharmacol Exp Ther Volume: 238 Page(s): 508 - 514
08/01/1986 Authors: Cubells JF; Blanchard JS; Smith DM; Makman MH
Unilateral peri-substantia nigra catecholaminergic lesion and amygdala kindling.
Brain Res Volume: 370 Page(s): 388 - 392
04/09/1986 Authors: Albala BJ; Mosh SL; Cubells JF; Sharpless NS; Makman MH
Evidence for a role of endogenous opioids in the nigrostriatal system: influence of naloxone and morphine on nigrostriatal dopaminergic supersensitivity.
Brain Res Volume: 270 Page(s): 109 - 117
06/27/1983 Authors: Hirschhorn ID; Hittner D; Gardner EL; Cubells J; Makman MH
Neostriatal dopamine receptor loss and behavioral deficits in the senescent rat.
Life Sci Volume: 28 Page(s): 1215 - 1218
03/16/1981 Authors: Cubells JF; Joseph JA