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Profile

Jessica Cooper

  • Department of Psychiatry and Behavioral Sciences
    Assistant Professor
  • j.cooper@emory.edu
Head shot of Jessica Cooper

Overview

Dr. Jessica A. Cooper is an Assistant Professor in the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine and is the Associate Director for the Psychiatry Residency Research Track. She is also the Assistant Director of the Translational Research in Affective Disorders Laboratory in the Department of Psychology at Emory University. Dr. Cooper is currently funded by a K01 career development award from the National Institute of Mental Health to investigate elevated inflammation and altered glutamatergic functioning as transdiagnostic mediators of stress-induced anhedonia. She primarily studies the neurobiology of motivation, decision making, and response to reward using fMRI and computational modeling.

Research

Publications

  • Inflammation is associated with avolition and reduced resting state functional connectivity in corticostriatal reward circuitry in patients with schizophrenia.
    Neuropsychopharmacology
    04/24/2025 Authors: Goldsmith DR; Ning CS; Strauss GP; Gross RE; Cooper JA; Wommack EC; Haroon E; Felger JC; Walker EF; Treadway MT
  • A randomized proof-of-mechanism trial of TNF antagonism for motivational deficits and related corticostriatal circuitry in depressed patients with high inflammation.
    Mol Psychiatry Volume: 30 Page(s): 1407 - 1417
    04/01/2025 Authors: Treadway MT; Etuk SM; Cooper JA; Hossein S; Hahn E; Betters SA; Liu S; Arulpragasam AR; DeVries BAM; Irfan N
  • Medial prefrontal glutamate response to acute stress is associated with social subordination in female rhesus macaques.
    Transl Psychiatry Volume: 15 Page(s): 107
    03/29/2025 Authors: Treadway MT; Betters SA; Cooper JA; Li C-X; Zhang X; Michopoulos V
  • Computational Phenotyping of Effort-Based Decision Making in Unmedicated Adults With Remitted Depression.
    Biol Psychiatry Cogn Neurosci Neuroimaging
    02/24/2025 Authors: Kuhn M; Palermo EH; Pagnier G; Blank JM; Steinberger DC; Long Y; Nowicki G; Cooper JA; Treadway MT; Frank MJ
  • Spontaneous thought separates into clusters of negative, positive, and flexible thinking.
    Commun Psychol Volume: 3 Page(s): 21
    02/05/2025 Authors: Mig M; Cooper JA; Kragel PA; Treadway MT
  • Using Computational Phenotyping to Identify Divergent Strategies for Effort Allocation Across the Psychosis Spectrum.
    Schizophr Bull Volume: 50 Page(s): 1127 - 1136
    08/27/2024 Authors: Whitton AE; Cooper JA; Merchant JT; Treadway MT; Lewandowski KE
  • A randomized proof-of-mechanism trial of TNF antagonism for motivational anhedonia and related corticostriatal circuitry in depressed patients with high inflammation.

    03/05/2024 Authors: Treadway M; Etuk S; Cooper J; Hossein S; Hahn E; Betters S; Liu S; Arulpragasam A; DeVries B; Irfan N
  • Effects of acute stress and depression on functional connectivity between prefrontal cortex and the amygdala.
    Mol Psychiatry Volume: 28 Page(s): 4602 - 4612
    11/01/2023 Authors: Hossein S; Cooper JA; DeVries BAM; Nuutinen MR; Hahn EC; Kragel PA; Treadway MT
  • Hormone sensitivity predicts the beneficial effects of transdermal estradiol on reward-seeking behaviors in perimenopausal women: A randomized controlled trial.
    Psychoneuroendocrinology Volume: 156 Page(s): 106339
    10/01/2023 Authors: Swales DA; Lozza-Fiacco S; Andersen EH; Cooper JA; Treadway MT; Xia K; Schiller CE; Girdler SS; Dichter GS
  • Age-related differences in the social associative learning of trust information.
    Neurobiol Aging Volume: 125 Page(s): 32 - 40
    05/01/2023 Authors: Seaman KL; Christensen AP; Senn KD; Cooper JA; Cassidy BS
  • Increased Effort Expenditure in Major Depression Following a TNF-Alpha Antagonist is Mediated by Change in Systemic Immunometabolism
    Volume: 46 Page(s): 239 - 239
    12/01/2021 Authors: Etuk S; Hahn E; DeVries B; Cooper J; Irfan N; Harrison D; Nuutinen M; Lal A; Arulpragasam A; Hossein S
  • Acute drug effects differentially predict desire to take dextroamphetamine again for work and recreation.
    Psychopharmacology (Berl) Volume: 238 Page(s): 2815 - 2826
    10/01/2021 Authors: Hoots JK; Webber HE; Nunez C; Cooper JA; Lopez-Gamundi P; Lawlor VM; Lane SD; Treadway MT; Wardle MC
  • Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression.
    Nat Commun Volume: 12 Page(s): 3166
    05/26/2021 Authors: Cooper JA; Nuutinen MR; Lawlor VM; DeVries BAM; Barrick EM; Hossein S; Cole DJ; Leonard CV; Hahn EC; Teer AP
  • Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning.
    Neuropsychopharmacology Volume: 46 Page(s): 1078 - 1085
    05/01/2021 Authors: Soder HE; Cooper JA; Lopez-Gamundi P; Hoots JK; Nunez C; Lawlor VM; Lane SD; Treadway MT; Wardle MC
  • Distinct regions of the striatum underlying effort, movement initiation and effort discounting.
    Nat Hum Behav Volume: 5 Page(s): 378 - 388
    03/01/2021 Authors: Suzuki S; Lawlor VM; Cooper JA; Arulpragasam AR; Treadway MT
  • Using Computational Models to Examine Effort-Based Decision-Making in Psychopathology
    Volume: 44 Page(s): 65 - 66
    12/01/2019 Authors: Cooper J
  • Effortful goal-directed behavior in schizophrenia: Computational subtypes and associations with cognition.
    J Abnorm Psychol Volume: 128 Page(s): 710 - 722
    10/01/2019 Authors: Cooper JA; Barch DM; Reddy LF; Horan WP; Green MF; Treadway MT
  • Can't or Won't? Immunometabolic Constraints on Dopaminergic Drive.
    Trends Cogn Sci Volume: 23 Page(s): 435 - 448
    05/01/2019 Authors: Treadway MT; Cooper JA; Miller AH
  • Anhedonia in depression: biological mechanisms and computational models.
    Curr Opin Behav Sci Volume: 22 Page(s): 128 - 135
    08/01/2018 Authors: Cooper JA; Arulpragasam AR; Treadway MT
  • Corticoinsular circuits encode subjective value expectation and violation for effortful goal-directed behavior.
    Proc Natl Acad Sci U S A Volume: 115 Page(s): E5233 - E5242
    05/29/2018 Authors: Arulpragasam AR; Cooper JA; Nuutinen MR; Treadway MT
  • Computational Models of Effort-Based Choice in Patients With Major Depression and Schizophrenia
    Volume: 83 Page(s): S19 - S19
    05/01/2018 Authors: Cooper J; Nusslock R; Craske M; Zinbarg R; Chat IK-Y; Barch D; Reddy F; Green M; Horan W; Treadway M
  • Association Between Interleukin-6 and Striatal Prediction-Error Signals Following Acute Stress in Healthy Female Participants.
    Biol Psychiatry Volume: 82 Page(s): 570 - 577
    10/15/2017 Authors: Treadway MT; Admon R; Arulpragasam AR; Mehta M; Douglas S; Vitaliano G; Olson DP; Cooper JA; Pizzagalli DA
  • Framing matters: Effects of framing on older adults' exploratory decision-making.
    Psychol Aging Volume: 32 Page(s): 60 - 68
    02/01/2017 Authors: Cooper JA; Blanco NJ; Maddox WT
  • Neural correlates of state-based decision-making in younger and older adults.
    Neuroimage Volume: 130 Page(s): 13 - 23
    04/15/2016 Authors: Worthy DA; Davis T; Gorlick MA; Cooper JA; Bakkour A; Mumford JA; Poldrack RA; Todd Maddox W
  • Information about foregone rewards impedes dynamic decision-making in older adults.
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn Volume: 23 Page(s): 103 - 116
    01/01/2016 Authors: Cooper JA; Worthy DA; Maddox WT
  • Chronic motivational state interacts with task reward structure in dynamic decision-making.
    Cogn Psychol Volume: 83 Page(s): 40 - 53
    12/01/2015 Authors: Cooper JA; Worthy DA; Maddox WT
  • The influence of expertise on essence beliefs for mental and medical disorder categories.
    Cognition Volume: 144 Page(s): 67 - 75
    11/01/2015 Authors: Cooper JA; Marsh JK
  • A frontal dopamine system for reflective exploratory behavior.
    Neurobiol Learn Mem Volume: 123 Page(s): 84 - 91
    09/01/2015 Authors: Blanco NJ; Love BC; Cooper JA; McGeary JE; Knopik VS; Maddox WT
  • State-based versus reward-based motivation in younger and older adults.
    Cogn Affect Behav Neurosci Volume: 14 Page(s): 1208 - 1220
    12/01/2014 Authors: Worthy DA; Cooper JA; Byrne KA; Gorlick MA; Maddox WT
  • Training attention improves decision making in individuals with elevated self-reported depressive symptoms.
    Cogn Affect Behav Neurosci Volume: 14 Page(s): 729 - 741
    06/01/2014 Authors: Cooper JA; Gorlick MA; Denny T; Worthy DA; Beevers CG; Maddox WT
  • Scaffolding across the lifespan in history-dependent decision-making.
    Psychol Aging Volume: 28 Page(s): 505 - 514
    06/01/2013 Authors: Cooper JA; Worthy DA; Gorlick MA; Maddox WT
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