Jae Won Chang
- Department of Pharmacology & Chemical Biology
Assistant Professor
- (404) 727-5939
- jae.won.chang@emory.edu
Overview
Large-scale profiling methods have uncovered numerous gene and protein expression changes that correlate with tumorigenesis. However, determining the relevance of these expression changes and which biochemical pathways they affect has been hindered by our incomplete understanding of the proteome and its myriad functions and modes of regulation. Activity-based profiling platforms enable both the discovery of cancer-relevant enzymes and selective pharmacological probes to perturb and characterize these proteins in tumor cells. When integrated with other large-scale profiling methods, activity-based proteomics can provide insight into the metabolic and signaling pathways that support cancer pathogenesis and illuminate new strategies for disease diagnosis and treatment. Overall goal of our lab is to understand how alterations in the function of proteins contribute to human disease and to identify individual proteins and cognate biochemical pathways that can be pharmacologically targeted for human disease. Therefore our laboratory is mainly focused on developing of novel chemical probes for profiling poorly characterized protein activities and drugs for prevention, diagnosis, treatment and cure of diseases like cancer and diabetes.
Academic Appointment
- Assistant Professor, Department of Pharmacology and Chemical Biology, Emory University School of Medicine
- Assistant Professor, Hematology and Medical Oncology, Emory University School of Medicine
- Member, Winship Cancer Institute, Discovery and Developmental Therapeutics Program, Emory University School of Medicine
Education
Degrees
- PhD from Scripps Research Institute
Research
Publications
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Development of a Dual-Factor Activatable Covalent Targeted Photoacoustic Imaging Probe for Tumor Imaging.
Angew Chem Int Ed Engl Volume: 63 Page(s): e202410645
10/01/2024 Authors: Song J; Zhai T; Hahm HS; Li Y; Mao H; Wang X; Jo J; Chang JW -
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.
Cancer Discov Volume: 13 Page(s): 1002 - 1025
04/03/2023 Authors: Stein BD; Ferrarone JR; Gardner EE; Chang JW; Wu D; Hollstein PE; Liang RJ; Yuan M; Chen Q; Coukos JS -
Soft Wireless Headband Bioelectronics and Electrooculography for Persistent Human-Machine Interfaces.
ACS Appl Electron Mater Volume: 5 Page(s): 877 - 886
02/28/2023 Authors: Ban S; Lee YJ; Kwon S; Kim Y-S; Chang JW; Kim J-H; Yeo W-H -
Effectiveness of the Fibrinogen-Thrombin-Impregnated Collagen Patch in the Prevention of Postoperative Complications after Parotidectomy: A Single-Blinded, Randomized Controlled Study.
J Clin Med Volume: 11
01/29/2022 Authors: Song K; Oh C; Won H-R; Koo BS; Kim DM; Yeo M-K; Choi Y; Chang JW -
Recent advances in development of hetero-bivalent kinase inhibitors.
Eur J Med Chem Volume: 216 Page(s): 113318
04/15/2021 Authors: Lee S; Kim J; Jo J; Chang JW; Sim J; Yun H -
InVivo Imaging of the Tumor-Associated Enzyme NCEH1 with a Covalent PET Probe.
Angew Chem Int Ed Engl Volume: 59 Page(s): 15161 - 15165
08/24/2020 Authors: Chang JW; Bhuiyan M; Tsai H-M; Zhang HJ; Li G; Fathi S; McCutcheon DC; Leoni L; Freifelder R; Chen C-T -
Systematic identification of genomic markers of drug sensitivity in cancer cells.
Nature Volume: 483 Page(s): 570 - 575
03/28/2012 Authors: Garnett MJ; Edelman EJ; Heidorn SJ; Greenman CD; Dastur A; Lau KW; Greninger P; Thompson IR; Luo X; Soares J