Publications

• A carnitine transporter at the blood-brain barrier modulates sleep via glial lipid metabolism in Drosophila.
  Proc Natl Acad Sci U S A Volume: 122 Page(s): e2421178122
  01/28/2025 Authors: Avila A; Lewandowski AS; Li Y; Gui J; Lee KA; Yang Z; Kim M; Lyles JT; Man K; Sehgal A
• Low-added sugar dietary intervention study to mitigate glucose intolerance and improve body composition in adults with cystic fibrosis: a protocol of a double-blind, randomised study.
  BMJ Open Volume: 14 Page(s): e092503
  12/26/2024 Authors: Zaveri S; Stecenko A; Hunt WR; Goss A; Sharma P; Hartman TJ; Easley K; Chandler JD; Burley TM; Driggers C
• Chronic hyperglycemia aggravates lung function in a Scnn1b-Tg murine model.
  Am J Physiol Lung Cell Mol Physiol Volume: 327 Page(s): L473 - L486
  10/01/2024 Authors: Cui G; Moustafa DA; Zhao S; Cegla AV; Lyles JT; Goldberg JB; Chandler JD; McCarty NA
• The therapeutic potential of thiocyanate and hypothiocyanous acid against pulmonary infections.
  Free Radic Biol Med Volume: 219 Page(s): 104 - 111
  07/01/2024 Authors: Ashtiwi NM; Kim SO; Chandler JD; Rada B
• Key inflammatory markers in bronchoalveolar lavage predict bronchiectasis progression in young children with CF.
  J Cyst Fibros Volume: 23 Page(s): 450 - 456
  05/01/2024 Authors: Horati H; Margaroli C; Chandler JD; Kilgore MB; Manai B; Andrinopoulou E-R; Peng L; Guglani L; Tiddens HAMW; Caudri D
• Nasal airway inflammatory responses and pathogen detection in infants with cystic fibrosis.
  J Cyst Fibros Volume: 23 Page(s): 219 - 225
  03/01/2024 Authors: Kopp BT; Ross SE; Bojja D; Guglani L; Chandler JD; Tirouvanziam R; Thompson M; Slaven JE; Chmiel JF; Siracusa C
• Sweat induction using Pilocarpine microneedle patches for sweat testing in healthy adults.
  J Cyst Fibros Volume: 23 Page(s): 112 - 119
  01/01/2024 Authors: Chen JY; Li S; Silva GL; Chandler JD; Prausnitz MR; Guglani L
• Substrate-dependent metabolomic signatures of myeloperoxidase activity in airway epithelial cells: Implications for early cystic fibrosis lung disease.
  Free Radic Biol Med Volume: 206 Page(s): 180 - 190
  09/01/2023 Authors: Kim SO; Shapiro JP; Cottrill KA; Collins GL; Shanthikumar S; Rao P; Ranganathan S; Stick SM; Orr ML; Fitzpatrick AM
• Metabolomics identifies disturbances in arginine, phenylalanine, and glycine metabolism as differentiating features of exacerbating atopic asthma in children.
  J Allergy Clin Immunol Glob Volume: 2
  08/01/2023 Authors: Cottrill KA; Chandler JD; Kobara S; Stephenson ST; Mohammad AF; Tidwell M; Mason C; Van Dresser M; Patrignani J; Kamaleswaran R
• The 'omics of obesity in B-cell acute lymphoblastic leukemia.
  J Natl Cancer Inst Monogr Volume: 2023 Page(s): 12 - 29
  05/04/2023 Authors: Geitgey DK; Lee M; Cottrill KA; Jaffe M; Pilcher W; Bhasin S; Randall J; Ross AJ; Salemi M; Castillo-Castrejon M
• Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19.
  Nat Commun Volume: 14 Page(s): 1638
  04/04/2023 Authors: Druzak S; Iffrig E; Roberts BR; Zhang T; Fibben KS; Sakurai Y; Verkerke HP; Rostad CA; Chahroudi A; Schneider F
• Study on the relationship between selenium and cadmium in diseased human lungs.
  Adv Redox Res Volume: 7
  04/01/2023 Authors: Smith MR; Hu X; Jarrell ZR; He X; Orr M; Fernandes J; Chandler JD; Walker DI; Esper A; Marts L
• Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load.
  Blood Adv Volume: 7 Page(s): 778 - 799
  03/14/2023 Authors: Eddins DJ; Yang J; Kosters A; Giacalone VD; Pechuan-Jorge X; Chandler JD; Eum J; Babcock BR; Dobosh BS; Hernndez MR
• Exacerbation-prone pediatric asthma is associated with arginine, lysine, and methionine pathway alterations.
  J Allergy Clin Immunol Volume: 151 Page(s): 118 - 127.e10
  01/01/2023 Authors: Cottrill KA; Stephenson ST; Mohammad AF; Kim SO; McCarty NA; Kamaleswaran R; Fitzpatrick AM; Chandler JD
• Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease.
  J Cyst Fibros Volume: 21 Page(s): 967 - 976
  11/01/2022 Authors: Margaroli C; Horati H; Garratt LW; Giacalone VD; Schofield C; Dittrich AS; Rosenow T; Dobosh BS; Lim HS; Frey DL
• Immunometabolic Analysis of Synovial Fluid from Juvenile Idiopathic Arthritis Patients.
  Immunohorizons Volume: 6 Page(s): 768 - 778
  11/01/2022 Authors: Giacalone VD; Cammarata-Mouchtouris A; Moncada-Giraldo D; Shenoy SPV; Ponder LA; Gergely TR; Kim SO; Chandler JD; Vega-Fernandez P; Manos CK
• Pilot study of inflammatory biomarkers in matched induced sputum and bronchoalveolar lavage of 2-year-olds with cystic fibrosis.
  Pediatr Pulmonol Volume: 57 Page(s): 2189 - 2198
  09/01/2022 Authors: Giacalone VD; Moncada-Giraldo D; Margaroli C; Brown MR; Silva GL; Chandler JD; Peng L; Tirouvanziam R; Guglani L; IMPEDE-CF Program
• Metabolomics of airways disease in cystic fibrosis.
  Curr Opin Pharmacol Volume: 65 Page(s): 102238
  08/01/2022 Authors: Chandler JD; Esther CR
• Inactivation of SARS-CoV-2 and COVID-19 Patient Samples for Contemporary Immunology and Metabolomics Studies.
  Immunohorizons Volume: 6 Page(s): 144 - 155
  02/16/2022 Authors: Eddins DJ; Bassit LC; Chandler JD; Haddad NS; Musall KL; Yang J; Kosters A; Dobosh BS; Hernndez MR; Ramonell RP
• Analysis of Redox and Bioenergetics Metabolites with Polymeric iHILIC (R)-(P) Classic HILIC Column and Mass Spectrometry
  LC GC EUROPE Volume: 34 Page(s): 397 - 398
  09/01/2021 Authors: Kim S; Jiang W; Chandler JD
• Dual oxidase 1 promotes antiviral innate immunity.
  Proc Natl Acad Sci U S A Volume: 118
  06/29/2021 Authors: Sarr D; Gingerich AD; Asthiwi NM; Almutairi F; Sautto GA; Ecker J; Nagy T; Kilgore MB; Chandler JD; Ross TM
• Analysis of Redox and Bioenergetics Metabolites with Polymeric iHILIC (R)-(P) Classic HILIC Column and Mass Spectrometry
  LC GC NORTH AMERICA Volume: 39 Page(s): 293 - 294
  06/01/2021 Authors: Kim S; Jiang W; Chandler JD
• Analysis of Redox and Bioenergetics Metabolites with Polymeric iHILIC (R)-(P) Classic HILIC Column and Mass Spectrometry
  LC GC EUROPE Volume: 34 Page(s): 213 - 214
  05/01/2021 Authors: Kim S; Jiang W; Chandler JD
• OMICS INTEGRATION TO ASSESS IN VITRO RHINOVIRUS INFECTION IN CHILDREN WITH AND WITHOUT CYSTIC FIBROSIS (CF)
  Volume: 26 Page(s): 48 - 48
  04/01/2021 Authors: Agudelo-Romero P; Chandler J; Ling K; Sutanto E; Jones D; Tirovanzium R; Garratt L; Stick S; Kicic A; Arest CF
• Airway profile of bioactive lipids predicts early progression of lung disease in cystic fibrosis.
  J Cyst Fibros Volume: 19 Page(s): 902 - 909
  11/01/2020 Authors: Horati H; Janssens HM; Margaroli C; Veltman M; Stolarczyk M; Kilgore MB; Chou J; Peng L; Tiddens HAMW; Chandler JD
• METABOLOMICS OF INDUCED SPUTUM IN EARLY CYSTIC FIBROSIS
  Volume: 55 Page(s): S52 - S53
  10/01/2020 Authors: Moncada DM; Giacalone VD; Kilgore MB; Brown M; Silva GL; Esther CR; Tirouvanziam R; Guglani L; Chandler JD
• INDUCED SPUTUM COLLECTION AS A NON-INVASIVE METHOD TO INVESTIGATE INFLAMMATORY MARKERS OF EARLY CF LUNG DISEASE
  Volume: 55 Page(s): S42 - S42
  10/01/2020 Authors: Giacalone VD; Moncada DM; Margaroli C; Brown M; Silva GL; Peng L; Chandler JD; Tirouvanziam R; Guglani L
• Using integrated omics to assess the effects of rhinovirus infection in children with Cystic Fibrosis (CF)
  Volume: 56
  09/07/2020 Authors: Agudelo-Romero P; Martinovich K; Chandler JD; Ling K-M; Sutanto EN; Jones DP; Tirouvanzium RM; Stick SM; Garratt LW; Kicic A
• The thiocyanate analog selenocyanate is a more potent antimicrobial pro-drug that also is selectively detoxified by the host.
  Free Radic Biol Med Volume: 146 Page(s): 324 - 332
  01/01/2020 Authors: Day BJ; Bratcher PE; Chandler JD; Kilgore MB; Min E; LiPuma JJ; Hondal RJ; Nichols DP
• PLASMA METABOLOMIC PROFILING OF HOSPITALIZED ADULTS ACROSS THE SPECTRUM OF GLUCOSE TOLERANCE
  Volume: 54 Page(s): S219 - S220
  10/01/2019 Authors: Alvarez JA; Bellissimo MP; Chandler JD; Uppal K; Walker D; Olveira G; Jones DP; Ziegler TR; Tangpricha V
• FEASIBILITY OF EXHALED BREATH CONDENSATE COLLECTION AND METABOLOMICS IN YOUNG CHILDREN WITH CYSTIC FIBROSIS: A PILOT STUDY
  Volume: 54 Page(s): S341 - S341
  10/01/2019 Authors: Chandler JD; Kilgore MB; Silva GL; Peng L; Tirouvanziam R; Guglani L
• INDUCED SPUTUM AS AN ALTERNATIVE TO BRONCHOALVEOLAR LAVAGE FOR EVALUATION OF AIRWAY INFLAMMATION IN YOUNG CHILDREN WITH CYSTIC FIBROSIS
  Volume: 54 Page(s): S157 - S158
  10/01/2019 Authors: Giacalone VD; Margaroli C; Dobosh B; Brown M; Silva GL; Peng L; Chandler JD; Tirouvanziam R; Guglani L
• WORSENING GLUCOSE INTOLERANCE WITH PULMONARY EXACERBATIONS
  Volume: 54 Page(s): S224 - S225
  10/01/2019 Authors: Vala SK; Guglani L; Chandler JD; Stecenko A
• DISCOVERY OF AIRWAY FLUID PROTEINS ASSOCIATED WITH PROGRESSIVE AIRWAY DISEASE IN YOUNG CHILDREN WITH CYSTIC FIBROSIS
  Volume: 54 Page(s): S328 - S328
  10/01/2019 Authors: Chou J; Horati H; Margaroli C; Tiddens HA; Scholte BJ; Chandler JD; Tirouvanziam R; Janssens HM; Peng L
• Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice.
  Environ Int Volume: 127 Page(s): 720 - 729
  06/01/2019 Authors: Chandler JD; Hu X; Ko E-J; Park S; Fernandes J; Lee Y-T; Orr ML; Hao L; Smith MR; Neujahr DC
• Metabolomic Responses to Manganese Dose in SH-SY5Y Human Neuroblastoma Cells.
  Toxicol Sci Volume: 169 Page(s): 84 - 94
  05/01/2019 Authors: Fernandes J; Chandler JD; Liu KH; Uppal K; Hao L; Hu X; Go Y-M; Jones DP
• Low-dose cadmium disrupts mitochondrial citric acid cycle and lipid metabolism in mouse lung.
  Free Radic Biol Med Volume: 131 Page(s): 209 - 217
  02/01/2019 Authors: Hu X; Chandler JD; Park S; Liu K; Fernandes J; Orr M; Smith MR; Ma C; Kang S-M; Uppal K
• Transcriptome Analysis Reveals Distinct Responses to Physiologic versus Toxic Manganese Exposure in Human Neuroblastoma Cells.
  Front Genet Volume: 10 Page(s): 676
  01/01/2019 Authors: Fernandes J; Chandler JD; Lili LN; Uppal K; Hu X; Hao L; Go Y-M; Jones DP
• Low-dose cadmium disrupts mitochondrial citric acid cycle and lipid metabolism in mouse lung
  Volume: 128 Page(s): S86 - S86
  11/20/2018 Authors: Hu X; Chandler J; Park S; Liu KH; Fernandes J; Orr M; Smith MR; Ma C; Kang S-M; Uppal K
• Influence of pH on the reactions of heme peroxidase-derived oxidants with R19S
  Volume: 128 Page(s): S101 - S102
  11/20/2018 Authors: Kilgore MB; Morrison KR; Wuest WM; Chandler JD
• Selenium supplementation prevents metabolic and transcriptomic responses to cadmium in mouse lung.
  Biochim Biophys Acta Gen Subj Volume: 1862 Page(s): 2417 - 2426
  11/01/2018 Authors: Hu X; Chandler JD; Fernandes J; Orr ML; Hao L; Uppal K; Neujahr DC; Jones DP; Go Y-M
• Determination of thiocyanate in exhaled breath condensate.
  Free Radic Biol Med Volume: 126 Page(s): 334 - 340
  10/01/2018 Authors: Chandler JD; Horati H; Walker DI; Pagliano E; Tirouvanziam R; Veltman M; Scholte BJ; Janssens HM; Go Y-M; Jones DP
• Myeloperoxidase oxidation of methionine associates with early cystic fibrosis lung disease.
  Eur Respir J Volume: 52
  10/01/2018 Authors: Chandler JD; Margaroli C; Horati H; Kilgore MB; Veltman M; Liu HK; Taurone AJ; Peng L; Guglani L; Uppal K
• RESPONSES OF FLUORESCENT PROBE R19S TO MYELOPEROXIDASE-DERIVED OXIDANTS FOUND IN CYSTIC FIBROSIS AIRWAYS
  Volume: 53 Page(s): 191 - 191
  09/01/2018 Authors: Kilgore MB; Morrison KR; Wuest W; Chandler JD
• METHIONINE OXIDATION BY MYELOPEROXIDASE IS ASSOCIATED WITH EARLY CYSTIC FIBROSIS LUNG DISEASE
  Volume: 53 Page(s): 262 - 262
  09/01/2018 Authors: Chandler JD; Margaroli C; Horati H; Kilgore MB; Veltman M; Liu HK; Taurone AJ; Peng L; Guglani L; Uppal K
• Putrescine as indicator of manganese neurotoxicity: Dose-response study in human SH-SY5Y cells.
  Food Chem Toxicol Volume: 116 Page(s): 272 - 280
  06/01/2018 Authors: Fernandes J; Chandler JD; Liu KH; Uppal K; Go Y-M; Jones DP
• Selenium Supplementation Alters Hepatic Energy and Fatty Acid Metabolism in Mice.
  J Nutr Volume: 148 Page(s): 675 - 684
  05/01/2018 Authors: Hu X; Chandler JD; Orr ML; Hao L; Liu K; Uppal K; Go Y-M; Jones DP
• Integrative Omics-identified Potential Toxicity of Environmental and Nutritional Metals
  Volume: 112 Page(s): 164 - 164
  11/01/2017 Authors: Go Y-M; Hu X; Chandler J; Jones DP
• Corrigendum to "Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration" [Metabolism vol. 70, May 2017, pages 31-41].
  Metabolism Volume: 74 Page(s): 41 - 42
  09/01/2017 Authors: Alvarez JA; Chong EY; Walker DI; Chandler JD; Michalski ES; Grossmann RE; Uppal K; Li S; Frediani JK; Tirouvanziam R
• Integrative omics-defined redox, metabolic and functional responses to environmental metal exposure
  Volume: 108 Page(s): S106 - S106
  07/01/2017 Authors: Go Y-M; Hu X; Chandler J; Fernandes J; Jones DP
• Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform.
  Ann N Y Acad Sci Volume: 1397 Page(s): 119 - 129
  06/01/2017 Authors: Cornely RM; Schlingmann B; Shepherd WS; Chandler JD; Neujahr DC; Koval M
• Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration.
  Metabolism Volume: 70 Page(s): 31 - 41
  05/01/2017 Authors: Alvarez JA; Chong EY; Walker DI; Chandler JD; Michalski ES; Grossmann RE; Uppal K; Li S; Frediani JK; Tirouvanziam R
• From the Cover: Manganese Stimulates Mitochondrial H2O2 Production in SH-SY5Y Human Neuroblastoma Cells Over Physiologic as well as Toxicologic Range.
  Toxicol Sci Volume: 155 Page(s): 213 - 223
  01/01/2017 Authors: Fernandes J; Hao L; Bijli KM; Chandler JD; Orr M; Hu X; Jones DP; Go Y-M
• Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice.
  Am J Physiol Regul Integr Comp Physiol Volume: 311 Page(s): R906 - R916
  11/01/2016 Authors: Chandler JD; Hu X; Ko E-J; Park S; Lee Y-T; Orr M; Fernandes J; Uppal K; Kang S-M; Jones DP
• Lung Cysteine/cystine Redox Potential Increase Is Associated with Worse Inflammation and Disrupted Metabolism during H1N1 Infection and Exposure to Dietary Levels of Cadmium
  Volume: 100 Page(s): S52 - S52
  11/01/2016 Authors: Chandler JD; Hu X; Ko E; Park S; Fernandes J; Orr ML; Lee Y-T; Jones DP; Kang S-M; Go Y-M
• Integration of Multi-Omics Data Reveal Dynamic Oxidative Stress Responses to Manganese in Human SH-SY5Y Neuroblastoma Cells
  Volume: 100 Page(s): S160 - S160
  11/01/2016 Authors: Fernandes J; Uppal K; Chandler JD; Lili LN; Hu X; Go Y-M; Jones DP
• Human Lung Disease-Associated Proteins Are Oxidized in Mouse Lung by Cadmium Levels Found in Human Environmental and Dietary Exposures
  Volume: 100 Page(s): S24 - S24
  11/01/2016 Authors: Go Y-M; Chandler JD; Orr M; Liang Y; Jones DP
• UNTARGETED METABOLOMICS OF CF INFANT BALF IDENTIFIES SIGNATURES ASSOCIATED WITH EARLY AIRWAY DISEASE BASED ON PRAGMA CT SCORING
  Volume: 51 Page(s): 236 - 237
  10/01/2016 Authors: Chandler JD; Horati H; Scholte BJ; Jones DP; Peng L; Gaggar A; Janssens H; Tirouvanziam R
• BACTERIAL THIOREDOXIN REDUCTASE IS A TARGET FOR HYPOTHIOCYANITE-MEDIATED ANTIMICROBIAL EFFECTS
  Volume: 51 Page(s): 221 - 221
  10/01/2016 Authors: Day BJ; Min E; Nichols D; Chandler JD
• Low-dose oral cadmium increases airway reactivity and lung neuronal gene expression in mice.
  Physiol Rep Volume: 4
  07/01/2016 Authors: Chandler JD; Wongtrakool C; Banton SA; Li S; Orr ML; Barr DB; Neujahr DC; Sutliff RL; Go Y-M; Jones DP
• Anticancer therapeutic potential of Mn porphyrin/ascorbate system.
  Free Radic Biol Med Volume: 89 Page(s): 1231 - 1247
  12/01/2015 Authors: Tovmasyan A; Sampaio RS; Boss M-K; Bueno-Janice JC; Bader BH; Thomas M; Reboucas JS; Orr M; Chandler JD; Go Y-M
• Low-Dose Cadmium Causes Metabolic and Genetic Dysregulation Associated With Fatty Liver Disease in Mice.
  Toxicol Sci Volume: 147 Page(s): 524 - 534
  10/01/2015 Authors: Go Y-M; Sutliff RL; Chandler JD; Khalidur R; Kang B-Y; Anania FA; Orr M; Hao L; Fowler BA; Jones DP
• Antiinflammatory and Antimicrobial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model.
  Am J Respir Cell Mol Biol Volume: 53 Page(s): 193 - 205
  08/01/2015 Authors: Chandler JD; Min E; Huang J; McElroy CS; Dickerhof N; Mocatta T; Fletcher AA; Evans CM; Liang L; Patel M
• The cysteine proteome.
  Free Radic Biol Med Volume: 84 Page(s): 227 - 245
  07/01/2015 Authors: Go Y-M; Chandler JD; Jones DP
• Biochemical mechanisms and therapeutic potential of pseudohalide thiocyanate in human health.
  Free Radic Res Volume: 49 Page(s): 695 - 710
  06/01/2015 Authors: Chandler JD; Day BJ
• Sarcoendoplasmic reticulum Ca(2+) ATPase. A critical target in chlorine inhalation-induced cardiotoxicity.
  Am J Respir Cell Mol Biol Volume: 52 Page(s): 492 - 502
  04/01/2015 Authors: Ahmad S; Ahmad A; Hendry-Hofer TB; Loader JE; Claycomb WC; Mozziconacci O; Schneich C; Reisdorph N; Powell RL; Chandler JD
• Nebulized thiocyanate improves lung infection outcomes in mice.
  Br J Pharmacol Volume: 169 Page(s): 1166 - 1177
  07/01/2013 Authors: Chandler JD; Min E; Huang J; Nichols DP; Day BJ
• Selective metabolism of hypothiocyanous acid by mammalian thioredoxin reductase promotes lung innate immunity and antioxidant defense.
  J Biol Chem Volume: 288 Page(s): 18421 - 18428
  06/21/2013 Authors: Chandler JD; Nichols DP; Nick JA; Hondal RJ; Day BJ
• Thiocyanate: a potentially useful therapeutic agent with host defense and antioxidant properties.
  Biochem Pharmacol Volume: 84 Page(s): 1381 - 1387
  12/01/2012 Authors: Chandler JD; Day BJ