Jimena Andersen
- Department of Human Genetics
Assistant Professor
-
615 Michael Street
Suite 305M
Atlanta, GA 30322
Overview
The main goal of the lab is to understand at a cellular and tissue levels what are the mechanisms that shape the development and function of the spinal cord and associated motor system, and understand how these mechanisms might go awry during disease. In particular, the lab focuses on studying cell-cell interactions in this context and answering two questions: how do cell-to-cell interactions regulate the development and function of the human spinal cord and motor system? And how do aberrations in cell-to-cell interactions contribute to disease? Towards this goal the lab uses stem cell-derived organoid and assembloid technologies in combination with state-of-the-art molecular and functional techniques.
Academic Appointment
- Assistant Professor, Human Genetics, Emory University
Education
Degrees
- PhD, Cell and Developmental Biology from National Institute for Medical Research
- BSc (Hons) Biology from University of Bath
Research
Publications
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Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway.
Neuron Volume: 112 Page(s): 4048 - 4059.e7
12/18/2024 Authors: Kim J-I; Miura Y; Li M-Y; Revah O; Selvaraj S; Birey F; Meng X; Thete MV; Pavlov SD; Andersen J -
Neuron-Astrocyte Interactions: A Human Perspective.
Adv Neurobiol Volume: 39 Page(s): 69 - 93
01/01/2024 Authors: Pio T; Hill EJ; Kebede N; Andersen J; Sloan SA -
Single-cell transcriptomic landscape of the developing human spinal cord.
Nat Neurosci Volume: 26 Page(s): 902 - 914
05/01/2023 Authors: Andersen J; Thom N; Shadrach JL; Chen X; Onesto MM; Amin ND; Yoon S-J; Li L; Greenleaf WJ; Mller F -
Maturation and circuit integration of transplanted human cortical organoids.
Nature Volume: 610 Page(s): 319 - 326
10/01/2022 Authors: Revah O; Gore F; Kelley KW; Andersen J; Sakai N; Chen X; Li M-Y; Birey F; Yang X; Saw NL -
Generation of Functional Human 3D Cortico-Motor Assembloids.
Cell Volume: 183 Page(s): 1913 - 1929.e26
12/23/2020 Authors: Andersen J; Revah O; Miura Y; Thom N; Amin ND; Kelley KW; Singh M; Chen X; Thete MV; Walczak EM -
Chromatin accessibility dynamics in a model of human forebrain development.
Science Volume: 367
01/24/2020 Authors: Trevino AE; Sinnott-Armstrong N; Andersen J; Yoon S-J; Huber N; Pritchard JK; Chang HY; Greenleaf WJ; Paca SP -
Absent forebrain replaced by embryonic stem cells.
Nature Volume: 563 Page(s): 44 - 45
11/01/2018 Authors: Andersen J; Paca SP -
Generation and assembly of human brain region-specific three-dimensional cultures.
Nat Protoc Volume: 13 Page(s): 2062 - 2085
09/01/2018 Authors: Sloan SA; Andersen J; Paca AM; Birey F; Paca SP -
Assembly of functionally integrated human forebrain spheroids.
Nature Volume: 545 Page(s): 54 - 59
05/04/2017 Authors: Birey F; Andersen J; Makinson CD; Islam S; Wei W; Huber N; Fan HC; Metzler KRC; Panagiotakos G; Thom N -
Return to quiescence of mouse neural stem cells by degradation of a proactivation protein.
Science Volume: 353 Page(s): 292 - 295
07/15/2016 Authors: Urbn N; van den Berg DLC; Forget A; Andersen J; Demmers JAA; Hunt C; Ayrault O; Guillemot F