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Profile

John Altman PhD

  • Department of Microbiology and Immunology
    Associate Professor
  • (404) 727-5981
  • jaltman@emory.edu
  • NIH Tetramer Facility
  • Emory Vaccine Center at Emory National Primate Research Center
    954 Gatewood Rd, NE
Head shot of John Altman

Overview

While most efficacious vaccines are thought to work through elicitation of neutralizing antibodies, the pathogens that cause diseases such as AIDS and malaria are notoriously difficult to neutralize with antibodies, leading vaccine developers to test the efficacy of vaccines designed specifically to elicit strong T cell responses, in the hope that a rapid secondary T cell response could limit early dissemination of the pathogen before it has the opportunity to establish a chronic infection. These efforts are complicated by the fact that antigen-specific memory T cell populations are phenotypically heterogeneous, and the role of defined subpopulations in secondary immune responses remains hotly debated. Our MHC tetramer technology has played an essential role in defining the distribution of T cell subsets specific for a variety of pathogens, and this continues to be a central focus of the work in our laboratory. We are interested in both defining the relationships between T cell phenotypes and effector functions that can be assessed using short-term in vitro assays (that do not require amplification of T cell populations), as well as using adoptive transfer experiments in mouse models that permit in vivo testing of the efficacy of purified T cell subsets. In support of these studies, we are actively engaged in the development of new technologies that will (1) permit more rapid assessment of T cell responses to large pathogens as well as mapping of T cell epitopes and (2) permit multiparametric flow cytometry assessment of T cell phenotypes.

Research Topics:
-Cellular And Molecular Immunology
-Development Of Novel Vaccines
-Emerging Infectious Diseases
-Viral Pathogenesis

Academic Appointment

  • Affiliate Scientist, Emory Regional Primate Center of Emory University
  • Associate Professor of Microbiology and Immunology, Emory University School of Medicine
  • Affiliate Scientist, Emory Vaccine Center

Education

Degrees

  • SB from Massachusetts Institute of Technology
  • PhD from University of California

Research

Focus

  • The research of my laboratory is focused upon the induction, function, trafficking, and regulation of antiviral T cell immune responses. We pursue studies in mouse, nonhuman primate, and human models, with the ultimate goal of developing principles and applications that result in improved vaccines for humans

Publications

  • Frequency-potency analysis of IgG+ memory B cells delineates neutralizing antibody responses at single-cell resolution.
    Cell Rep Volume: 43 Page(s): 113948
    03/26/2024 Authors: Tenggara MK; Oh S-H; Yang C; Nariya HK; Metz AM; Upadhyay AA; Gudipati DR; Guo L; McGhee EG; Gill K
  • Rare Variable M. tuberculosis Antigens induce predominant Th17 responses in human infection.
    bioRxiv
    03/06/2024 Authors: Ogongo P; Wassie L; Tran A; Columbus D; Sharling L; Ouma G; Ouma SG; Bobosha K; Lindestam Arlehamn CS; Gandhi NR
  • CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms.
    Cell Volume: 186 Page(s): 4583 - 4596.e13
    10/12/2023 Authors: Huang S; Shahine A; Cheng T-Y; Chen Y-L; Ng SW; Balaji GR; Farquhar R; Gras S; Hardman CS; Altman JD
  • The Long-Awaited Respiratory Syncytial Virus Vaccine.
    J Interferon Cytokine Res Volume: 43 Page(s): 285 - 286
    07/01/2023 Authors: Altman JD; Rouse BT
  • Spheromers reveal robust Tcell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ Tcell responses post SARS-CoV-2 infection.
    Immunity Volume: 56 Page(s): 864 - 878.e4
    04/11/2023 Authors: Gao F; Mallajosyula V; Arunachalam PS; van der Ploeg K; Manohar M; Rltgen K; Yang F; Wirz O; Hoh R; Haraguchi E
  • The Impact of Diabetes and Prediabetes on Prevalence of Mycobacterium tuberculosis Infection Among Household Contacts of Active Tuberculosis Cases in Ethiopia.
    Open Forum Infect Dis Volume: 9 Page(s): ofac323
    07/01/2022 Authors: Smith AGC; Kempker RR; Wassie L; Bobosha K; Nizam A; Gandhi NR; Auld SC; Magee MJ; Blumberg HM; Tuberculosis Research Unit: Role of Antigen Specific Responses in the Control of TB (TBRU-ASTRa) Study Group
  • T cells in COVID-19 - the kids are all right.
    Nat Immunol Volume: 23 Page(s): 647 - 649
    05/01/2022 Authors: Altman JD
  • Minimal Information about MHC Multimers (MIAMM).
    J Immunol Volume: 208 Page(s): 531 - 537
    02/01/2022 Authors: Vita R; Mody A; Overton JA; Buus S; Haley ST; Sette A; Mallajosyula V; Davis MM; Long DL; Willis RA
  • CD1a selectively captures endogenous cellular lipids that broadly block T cell response.
    J Exp Med Volume: 218
    07/05/2021 Authors: Cotton RN; Wegrecki M; Cheng T-Y; Chen Y-L; Veerapen N; Le Nours J; Orgill DP; Pomahac B; Talbot SG; Willis R
  • Isoniazid and Rifapentine Treatment Eradicates Persistent Mycobacterium tuberculosis in Macaques (Retraction of Vol 201, Pg 469, 2020)
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 203 Page(s): 1045 - 1045
    04/15/2021 Authors: Foreman TW; Bucsan AN; Mehra S; Peloquin C; Doyle LA; Russell-Lodrigue K; Gandhi NR; Altman J; Day CL; Ernst JD
  • T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette-Gurin Vaccination.
    J Immunol Volume: 206 Page(s): 1240 - 1250
    03/15/2021 Authors: Layton ED; Barman S; Wilburn DB; Yu KKQ; Smith MT; Altman JD; Scriba TJ; Tahiri N; Minnaard AJ; Roederer M
  • Production of Class II MHC Proteins in Lentiviral Vector-Transduced HEK-293T Cells for Tetramer Staining Reagents.
    Curr Protoc Volume: 1 Page(s): e36
    02/01/2021 Authors: Willis RA; Ramachandiran V; Shires JC; Bai G; Jeter K; Bell DL; Han L; Kazarian T; Ugwu KC; Laur O
  • Schistosoma mansoni Infection Is Associated With a Higher Probability of Tuberculosis Disease in HIV-Infected Adults in Kenya.
    J Acquir Immune Defic Syndr Volume: 86 Page(s): 157 - 163
    02/01/2021 Authors: McLaughlin TA; Nizam A; Hayara FO; Ouma GS; Campbell A; Khayumbi J; Ongalo J; Ouma SG; Shah NS; Altman JD
  • Human skin is colonized by T cells that recognize CD1a independently of lipid.
    J Clin Invest Volume: 131
    01/04/2021 Authors: Cotton RN; Cheng T-Y; Wegrecki M; Le Nours J; Orgill DP; Pomahac B; Talbot SG; Willis RA; Altman JD; de Jong A
  • Isoniazid and Rifapentine Treatment Eradicates Persistent Mycobacterium tuberculosis in Macaques.
    Am J Respir Crit Care Med Volume: 201 Page(s): 469 - 477
    02/15/2020 Authors: Foreman TW; Bucan AN; Mehra S; Peloquin C; Doyle LA; Russell-Lodrigue K; Gandhi NR; Altman J; Day CL; Ernst JD
  • MHC-I peptide binding activity assessed by exchange after cleavage of peptide covalently linked to 2-microglobulin.
    Anal Biochem Volume: 584 Page(s): 113328
    11/01/2019 Authors: Jurewicz MM; Willis RA; Ramachandiran V; Altman JD; Stern LJ
  • The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08+ Rhesus Macaques.
    J Virol Volume: 93
    03/01/2019 Authors: Martins MA; Gonzalez-Nieto L; Shin YC; Domingues A; Gutman MJ; Maxwell HS; Magnani DM; Ricciardi MJ; Pedreo-Lopez N; Bailey VK
  • Casting a wider net: Immunosurveillance by nonclassical MHC molecules.
    PLoS Pathog Volume: 15 Page(s): e1007567
    02/01/2019 Authors: D'Souza MP; Adams E; Altman JD; Birnbaum ME; Boggiano C; Casorati G; Chien Y-H; Conley A; Eckle SBG; Frh K
  • A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.
    Nat Commun Volume: 10 Page(s): 56
    01/04/2019 Authors: Shahine A; Reinink P; Reijneveld JF; Gras S; Holzheimer M; Cheng T-Y; Minnaard AJ; Altman JD; Lenz S; Prandi J
  • Delayed SIV infection in vaccinated, rectally-challenged Mamu-B*08+rhesus macaques in the absence of anti-Env humoral responses
    Volume: 47 Page(s): 339 - 339
    10/01/2018 Authors: Martins M; Shin Y; Gonzalez-Nieto L; Gutman M; Domingues A; Maxwell H; Magnani D; Ricciardi M; Pedreno-Lopez N; Bailey V
  • Mamu-B*17+ Rhesus Macaques Vaccinated with env, vif, and nef Manifest Early Control of SIVmac239 Replication.
    J Virol Volume: 92
    08/15/2018 Authors: Martins MA; Tully DC; Pedreo-Lopez N; von Bredow B; Pauthner MG; Shin YC; Yuan M; Lima NS; Bean DJ; Gonzalez-Nieto L
  • Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function.
    Elife Volume: 7
    05/09/2018 Authors: Geng J; Altman JD; Krishnakumar S; Raghavan M
  • A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection.
    J Immunol Volume: 200 Page(s): 3008 - 3019
    04/15/2018 Authors: Whatney WE; Gandhi NR; Lindestam Arlehamn CS; Nizam A; Wu H; Quezada MJ; Campbell A; Allana S; Kabongo MM; Khayumbi J
  • T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.
    Nat Immunol Volume: 19 Page(s): 397 - 406
    04/01/2018 Authors: Wun KS; Reijneveld JF; Cheng T-Y; Ladell K; Uldrich AP; Le Nours J; Miners KL; McLaren JE; Grant EJ; Haigh OL
  • Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU).
    PLoS One Volume: 13 Page(s): e0191837
    01/01/2018 Authors: Li K; Vorkas CK; Chaudhry A; Bell DL; Willis RA; Rudensky A; Altman JD; Glickman MS; Aub J
  • Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-nave individual during the 2016 outbreak in Miami, FL.
    PLoS Negl Trop Dis Volume: 11 Page(s): e0006000
    12/01/2017 Authors: Ricciardi MJ; Magnani DM; Grifoni A; Kwon Y-C; Gutman MJ; Grubaugh ND; Gangavarapu K; Sharkey M; Silveira CGT; Bailey VK
  • Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque.
    AIDS Res Hum Retroviruses Volume: 33 Page(s): 843 - 858
    08/01/2017 Authors: Martins MA; Tully DC; Shin YC; Gonzalez-Nieto L; Weisgrau KL; Bean DJ; Gadgil R; Gutman MJ; Domingues A; Maxwell HS
  • Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques.
    PLoS Pathog Volume: 13 Page(s): e1006529
    07/01/2017 Authors: Martins MA; Shin YC; Gonzalez-Nieto L; Domingues A; Gutman MJ; Maxwell HS; Castro I; Magnani DM; Ricciardi M; Pedreo-Lopez N
  • MHC-Peptide Tetramers to Visualize Antigen-Specific T Cells.
    Curr Protoc Immunol Volume: 115 Page(s): 17.3.1 - 17.3.44
    11/01/2016 Authors: Altman JD; Davis MM
  • Molecular Analysis of Lipid-Reactive V1 T Cells Identified by CD1c Tetramers.
    J Immunol Volume: 196 Page(s): 1933 - 1942
    02/15/2016 Authors: Roy S; Ly D; Castro CD; Li N-S; Hawk AJ; Altman JD; Meredith SC; Piccirilli JA; Moody DB; Adams EJ
  • Human autoreactive T cells recognize CD1b and phospholipids.
    Proc Natl Acad Sci U S A Volume: 113 Page(s): 380 - 385
    01/12/2016 Authors: Van Rhijn I; van Berlo T; Hilmenyuk T; Cheng T-Y; Wolf BJ; Tatituri RVV; Uldrich AP; Napolitani G; Cerundolo V; Altman JD
  • Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection.
    J Virol Volume: 89 Page(s): 10802 - 10820
    11/01/2015 Authors: Martins MA; Tully DC; Cruz MA; Power KA; Veloso de Santana MG; Bean DJ; Ogilvie CB; Gadgil R; Lima NS; Magnani DM
  • Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by T cells.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): E4648 - E4657
    10/28/2014 Authors: Roy S; Ly D; Li N-S; Altman JD; Piccirilli JA; Moody DB; Adams EJ
  • CD1a autoreactive T cells recognize natural skin lipids
    Volume: 134 Page(s): S8 - S8
    05/01/2014 Authors: de Jong A; Cheng T; Huang S; Gras S; Birkinshaw RW; Kasmar AG; Van Rhijn I; Pena-Cruz V; Ruan DT; Altman JD
  • CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens.
    Nat Immunol Volume: 15 Page(s): 177 - 185
    02/01/2014 Authors: de Jong A; Cheng T-Y; Huang S; Gras S; Birkinshaw RW; Kasmar AG; Van Rhijn I; Pea-Cruz V; Ruan DT; Altman JD
  • Cutting Edge: CD1a tetramers and dextramers identify human lipopeptide-specific T cells ex vivo.
    J Immunol Volume: 191 Page(s): 4499 - 4503
    11/01/2013 Authors: Kasmar AG; Van Rhijn I; Magalhaes KG; Young DC; Cheng T-Y; Turner MT; Schiefner A; Kalathur RC; Wilson IA; Bhati M
  • Evidence of a Less Pathogenic HIV Infection Associated with High Adaptation to HLA-I Mediated Immune Response in a South American Native Community
    Volume: 29 Page(s): A86 - A86
    11/01/2013 Authors: Dilernia DA; Monaco DC; Quipildor M; Di Paolo A; Yue L; Kaur S; Ibegbu C; Altman J; Salomon H; Hunter E
  • A conserved human T cell population targets mycobacterial antigens presented by CD1b.
    Nat Immunol Volume: 14 Page(s): 706 - 713
    07/01/2013 Authors: Van Rhijn I; Kasmar A; de Jong A; Gras S; Bhati M; Doorenspleet ME; de Vries N; Godfrey DI; Altman JD; de Jager W
  • Comparative lipidomics reveals a global sampling of major cellular membrane lipids by human CD1 proteins
    Volume: 190
    05/01/2013 Authors: Huang S; Cheng T-Y; Altman J; Moody DB
  • CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens.
    J Exp Med Volume: 210 Page(s): 729 - 741
    04/08/2013 Authors: Ly D; Kasmar AG; Cheng T-Y; de Jong A; Huang S; Roy S; Bhatt A; van Summeren RP; Altman JD; Jacobs WR
  • Platelets support a protective immune response to LCMV by preventing splenic necrosis.
    Blood Volume: 121 Page(s): 940 - 950
    02/07/2013 Authors: Loria GD; Romagnoli PA; Moseley NB; Rucavado A; Altman JD
  • CD8 T cell memory recall is enhanced by novel direct interactions with CD4 T cells enabled by MHC class II transferred from APCs.
    PLoS One Volume: 8 Page(s): e56999
    01/01/2013 Authors: Romagnoli PA; Premenko-Lanier MF; Loria GD; Altman JD
  • Deletion of specific immune-modulatory genes from modified vaccinia virus Ankara-based HIV vaccines engenders improved immunogenicity in rhesus macaques.
    J Virol Volume: 86 Page(s): 12605 - 12615
    12/01/2012 Authors: Garber DA; O'Mara LA; Gangadhara S; McQuoid M; Zhang X; Zheng R; Gill K; Verma M; Yu T; Johnson B
  • Lipids from human epidermis can function as antigens for CD1a-restricted T cells
    Volume: 132 Page(s): S106 - S106
    05/01/2012 Authors: de Jong A; Cheng T; Huang S; Kasmar AG; Pena-Cruz V; Altman J; Moody D
  • A CD1 lipidomic analysis determines the structures of human CD1b scaffold lipids and its function to enhance mycobacterial antigen presentation
    Volume: 188
    05/01/2012 Authors: Huang S; Cheng T-Y; Young D; Layre E; Madigan C; Shires J; Cerundolo V; Altman J; Moody B
  • CD8 T cell memory precursors are found in bone marrow upon activation after acute LCMV infection
    Volume: 188
    05/01/2012 Authors: Romagnoli P; Premenko-Lanier M; Loria G; Lefrancois L; Altman J
  • Use of replication restricted recombinant vesicular stomatitis virus vectors for detection of antigen-specific T cells.
    J Immunol Methods Volume: 375 Page(s): 118 - 128
    01/31/2012 Authors: Moseley NB; Laur O; Ibegbu CC; Loria GD; Ikwuenzunma G; Jayakar HR; Whitt MA; Altman JD
  • Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system.
    Proc Natl Acad Sci U S A Volume: 108 Page(s): 19335 - 19340
    11/29/2011 Authors: Huang S; Cheng T-Y; Young DC; Layre E; Madigan CA; Shires J; Cerundolo V; Altman JD; Moody DB
  • CD1b tetramers bind T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans.
    J Exp Med Volume: 208 Page(s): 1741 - 1747
    08/29/2011 Authors: Kasmar AG; van Rhijn I; Cheng T-Y; Turner M; Seshadri C; Schiefner A; Kalathur RC; Annand JW; de Jong A; Shires J
  • Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis.
    Nat Rev Immunol Volume: 11 Page(s): 551 - 558
    07/15/2011 Authors: Davis MM; Altman JD; Newell EW
  • Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.
    J Immunol Volume: 187 Page(s): 7 - 9
    07/01/2011 Authors: Altman JD; Moss PAH; Goulder PJR; Barouch DH; McHeyzer-Williams MG; Bell JI; McMichael AJ; Davis MM
  • New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation.
    J Immunol Volume: 183 Page(s): 7949 - 7957
    12/15/2009 Authors: Landais E; Romagnoli PA; Corper AL; Shires J; Altman JD; Wilson IA; Garcia KC; Teyton L
  • The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response.
    J Immunol Volume: 183 Page(s): 7919 - 7930
    12/15/2009 Authors: Akondy RS; Monson ND; Miller JD; Edupuganti S; Teuwen D; Wu H; Quyyumi F; Garg S; Altman JD; Del Rio C
  • Vaccine-induced, simian immunodeficiency virus-specific CD8+ T cells reduce virus replication but do not protect from simian immunodeficiency virus disease progression.
    J Immunol Volume: 183 Page(s): 706 - 717
    07/01/2009 Authors: Engram JC; Dunham RM; Makedonas G; Vanderford TH; Sumpter B; Klatt NR; Ratcliffe SJ; Garg S; Paiardini M; McQuoid M
  • IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection.
    Blood Volume: 113 Page(s): 6304 - 6314
    06/18/2009 Authors: Sereti I; Dunham RM; Spritzler J; Aga E; Proschan MA; Medvik K; Battaglia CA; Landay AL; Pahwa S; Fischl MA
  • Direct CD8:CD4 T cell interactions improve memory recall of CD8 T cells
    JOURNAL OF IMMUNOLOGY Volume: 182
    04/01/2009 Authors: Romagnoli PA; Premenko-Lanier MF; Loria GD; Altman JD
  • Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness.
    J Virol Volume: 83 Page(s): 2728 - 2742
    03/01/2009 Authors: Jagannathan P; Osborne CM; Royce C; Manion MM; Tilton JC; Li L; Fischer S; Hallahan CW; Metcalf JA; McLaughlin M
  • Development of Immunologically-Enhanced HIV Vaccines from Genetically Modified MVA Vectors
    Volume: 24 Page(s): 8 - 9
    10/01/2008 Authors: Garber DA; O'Mara L; Gill K; Zheng R; McQuoid M; Ibegbu C; Altman JD; Feinberg MB
  • Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes.
    J Infect Dis Volume: 198 Page(s): 500 - 507
    08/15/2008 Authors: Pulendran B; Miller J; Querec TD; Akondy R; Moseley N; Laur O; Glidewell J; Monson N; Zhu T; Zhu H
  • Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection.
    Nature Volume: 454 Page(s): 894 - 898
    08/14/2008 Authors: Premenko-Lanier M; Moseley NB; Pruett ST; Romagnoli PA; Altman JD
  • Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part II: Panel performance across different instrument platforms.
    Cytometry A Volume: 73 Page(s): 411 - 420
    05/01/2008 Authors: McLaughlin BE; Baumgarth N; Bigos M; Roederer M; De Rosa SC; Altman JD; Nixon DF; Ottinger J; Li J; Beckett L
  • Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines.
    Immunity Volume: 28 Page(s): 710 - 722
    05/01/2008 Authors: Miller JD; van der Most RG; Akondy RS; Glidewell JT; Albott S; Masopust D; Murali-Krishna K; Mahar PL; Edupuganti S; Lalor S
  • Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part I: Panel design by an empiric approach.
    Cytometry A Volume: 73 Page(s): 400 - 410
    05/01/2008 Authors: McLaughlin BE; Baumgarth N; Bigos M; Roederer M; De Rosa SC; Altman JD; Nixon DF; Ottinger J; Oxford C; Evans TG
  • CD8 T cell responses to live, viral Yellow fever vaccine in humans
    FASEB JOURNAL Volume: 22
    04/01/2008 Authors: Akondy R; Miller J; Monson N; Wu H; Quyyumi F; Mulligan M; Teuwen D; Altman J; Ahmed R
  • Loss of IFN-gamma enables the expansion of autoreactive CD4+ T cells to induce experimental autoimmune encephalomyelitis by a nonencephalitogenic myelin variant antigen.
    J Immunol Volume: 180 Page(s): 4451 - 4457
    04/01/2008 Authors: Sabatino JJ; Shires J; Altman JD; Ford ML; Evavold BD
  • IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses.
    J Immunol Volume: 180 Page(s): 350 - 360
    01/01/2008 Authors: Mueller YM; Do DH; Altork SR; Artlett CM; Gracely EJ; Katsetos CD; Legido A; Villinger F; Altman JD; Brown CR
  • Actin integrity is indispensable for CD95/Fas-induced apoptosis of HIV-specific CD8+ T cells.
    Apoptosis Volume: 12 Page(s): 2175 - 2186
    12/01/2007 Authors: Petrovas C; Mueller YM; Yang G; Altork SR; Jacobson JM; Pitsakis PG; Mounzer KC; Altman JD; Katsikis PD
  • Memory CD8+ T cells require CD28 costimulation.
    J Immunol Volume: 179 Page(s): 6494 - 6503
    11/15/2007 Authors: Borowski AB; Boesteanu AC; Mueller YM; Carafides C; Topham DJ; Altman JD; Jennings SR; Katsikis PD
  • Early establishment and antigen dependence of simian immunodeficiency virus-specific CD8+ T-cell defects.
    J Virol Volume: 81 Page(s): 10861 - 10868
    10/01/2007 Authors: Mueller YM; Petrovas C; Do DH; Altork SR; Fischer-Smith T; Rappaport J; Altman JD; Lewis MG; Katsikis PD
  • Activated CD8 T cells can stimulate CD4 T cells by direct interaction
    JOURNAL OF IMMUNOLOGY Volume: 178
    04/01/2007 Authors: Romagnoli PA; Altman JD
  • Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8(+) T cells.
    Blood Volume: 109 Page(s): 2505 - 2513
    03/15/2007 Authors: Petrovas C; Mueller YM; Dimitriou ID; Altork SR; Banerjee A; Sklar P; Mounzer KC; Altman JD; Katsikis PD
  • Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression.
    J Virol Volume: 81 Page(s): 2545 - 2553
    03/01/2007 Authors: Radziewicz H; Ibegbu CC; Fernandez ML; Workowski KA; Obideen K; Wehbi M; Hanson HL; Steinberg JP; Masopust D; Wherry EJ
  • A robust method for production of MHC tetramers with small molecule fluorophores.
    J Immunol Methods Volume: 319 Page(s): 13 - 20
    01/30/2007 Authors: Ramachandiran V; Grigoriev V; Lan L; Ravkov E; Mertens SA; Altman JD
  • A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells.
    J Immunol Methods Volume: 312 Page(s): 34 - 39
    05/30/2006 Authors: Liu Y; Goff RD; Zhou D; Mattner J; Sullivan BA; Khurana A; Cantu C; Ravkov EV; Ibegbu CC; Altman JD
  • DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T cell expansion.
    J Immunol Volume: 176 Page(s): 4562 - 4572
    04/15/2006 Authors: Chappell C; Beard C; Altman J; Jaenisch R; Jacob J
  • Multimeric Major Histocompatibility Complex Reagents for the Detection and Quantitation of Specific T-Cell Populations
    Page(s): 215 - +
    01/01/2006 Authors: Altman JD
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    Am J Trop Med Hyg Volume: 73 Page(s): 244 - 255
    08/01/2005 Authors: Tran TM; Oliveira-Ferreira J; Moreno A; Santos F; Yazdani SS; Chitnis CE; Altman JD; Meyer EV-S; Barnwell JW; Galinski MR
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    03/15/2005 Authors: Abdel-Motal UM; Gillis J; Manson K; Wyand M; Montefiori D; Stefano-Cole K; Montelaro RC; Altman JD; Johnson RP
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    J Immunol Volume: 174 Page(s): 2900 - 2909
    03/01/2005 Authors: Paiardini M; Cervasi B; Albrecht H; Muthukumar A; Dunham R; Gordon S; Radziewicz H; Piedimonte G; Magnani M; Montroni M
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    J Immunol Volume: 173 Page(s): 2524 - 2529
    08/15/2004 Authors: Kim AHJ; Dimitriou ID; Holland MCH; Mastellos D; Mueller YM; Altman JD; Lambris JD; Katsikis PD
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    J Immunol Volume: 172 Page(s): 4444 - 4453
    04/01/2004 Authors: Petrovas C; Mueller YM; Dimitriou ID; Bojczuk PM; Mounzer KC; Witek J; Altman JD; Katsikis PD
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    01/01/2004 Authors: Petrovas C; Muellerm YM; Dimitriou ID; Bojczuk PM; Mounzer K; Witek J; Altman JD; Katsikis PD
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    J Immunol Volume: 171 Page(s): 5372 - 5379
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    J Immunol Volume: 171 Page(s): 2393 - 2401
    09/01/2003 Authors: Maris CH; Miller JD; Altman JD; Jacob J
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    09/01/2003 Authors: Wang XL; Altman JD
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    J Immunol Volume: 167 Page(s): 1333 - 1337
    08/01/2001 Authors: Grayson JM; Lanier JG; Altman JD; Ahmed R
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    AIDS Res Hum Retroviruses Volume: 17 Page(s): 703 - 717
    05/20/2001 Authors: Bond KB; Sriwanthana B; Hodge TW; De Groot AS; Mastro TD; Young NL; Promadej N; Altman JD; Limpakarnjanarat K; McNicholl JM
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    Science Volume: 292 Page(s): 69 - 74
    04/06/2001 Authors: Amara RR; Villinger F; Altman JD; Lydy SL; O'Neil SP; Staprans SI; Montefiori DC; Xu Y; Herndon JG; Wyatt LS
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    FASEB JOURNAL Volume: 15 Page(s): A1050 - A1050
    03/08/2001 Authors: Halstead ES; Altman JD; Katsikis PD
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    03/07/2001 Authors: Gao XY; Altman JD; Suresh M
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    03/05/2001 Authors: Moser JM; Altman JD; Lukacher AE
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    J Virol Volume: 75 Page(s): 2458 - 2461
    03/01/2001 Authors: Vogel TU; Allen TM; Altman JD; Watkins DI
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    J Virol Volume: 75 Page(s): 3028 - 3033
    03/01/2001 Authors: Xiong Y; Luscher MA; Altman JD; Hulsey M; Robinson HL; Ostrowski M; Barber BH; MacDonald KS
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    Int Immunol Volume: 13 Page(s): 265 - 271
    03/01/2001 Authors: Sherritt M; Cooper L; Moss DJ; Kienzle N; Altman J; Khanna R
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    ScientificWorldJournal Volume: 1 Page(s): 53
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    J Immunol Volume: 165 Page(s): 6229 - 6234
    12/01/2000 Authors: Burrows SR; Kienzle N; Winterhalter A; Bharadwaj M; Altman JD; Brooks A
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    09/21/2000 Authors: Allen TM; O'Connor DH; Jing P; Dzuris JL; Moth BR; Vogel TU; Dunphy E; Liebl ME; Emerson C; Wilson N
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    08/25/2000 Authors: Huang CC; Coppola MA; Nguyen P; Carragher D; Rohl C; Flynn KJ; Altman JD; Blackman MA
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    07/15/2000 Authors: Gea-Banacloche JC; Migueles SA; Martino L; Shupert WL; McNeil AC; Sabbaghian MS; Ehler L; Prussin C; Stevens R; Lambert L
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    05/01/2000 Authors: Drake DR; Moser JM; Hadley A; Altman JD; Maliszewski C; Butz E; Lukacher AE
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    04/20/2000 Authors: Zajac AJ; Lau L; Altman JD; Ahmed R
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    FASEB JOURNAL Volume: 14 Page(s): A971 - A971
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    04/01/2000 Authors: Bosselut R; Kubo S; Guinter T; Kopacz JL; Altman JD; Feigenbaum L; Singer A
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    03/29/2000 Authors: Whitmire JK; Murali-Krishna K; Altman J; Ahmed R
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  • Examination of proliferation and migration of CD8+T cells into the mouse intestinal mucosa during primary and secondary immune responses
    FASEB JOURNAL Volume: 13 Page(s): A607 - A607
    03/12/1999 Authors: Masopust D; Altman JD; Lefrancois L
  • Massive expansion of antigen-specific CTL during polyoma virus infection
    FASEB JOURNAL Volume: 13 Page(s): A638 - A638
    03/12/1999 Authors: Lukacher AE; Moser JM; Altman JD
  • Protection against a lethal avian influenza A virus in a mammalian system.
    J Virol Volume: 73 Page(s): 1453 - 1459
    02/01/1999 Authors: Riberdy JM; Flynn KJ; Stech J; Webster RG; Altman JD; Doherty PC
  • Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART).
    J Immunol Volume: 162 Page(s): 1780 - 1788
    02/01/1999 Authors: Gray CM; Lawrence J; Schapiro JM; Altman JD; Winters MA; Crompton M; Loi M; Kundu SK; Davis MM; Merigan TC
  • Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy.
    J Immunol Volume: 162 Page(s): 1765 - 1771
    02/01/1999 Authors: Bieganowska K; Hllsberg P; Buckle GJ; Lim DG; Greten TF; Schneck J; Altman JD; Jacobson S; Ledis SL; Hanchard B
  • T-cell anergy during chronic viral infection
    Page(s): 243 - 253
    01/01/1999 Authors: Blattman JN; Zajac AJ; Murali-Krishna K; Sourdive DJD; Suresh M; Altman JD; Ahmed R
  • Virus-specific CD8(+) T cell numbers are maintained during gamma-herpesvirus reactivation in CD4-deficient mice.
    Proc Natl Acad Sci U S A Volume: 95 Page(s): 15565 - 15570
    12/22/1998 Authors: Stevenson PG; Belz GT; Altman JD; Doherty PC
  • Viral immune evasion due to persistence of activated T cells without effector function.
    J Exp Med Volume: 188 Page(s): 2205 - 2213
    12/21/1998 Authors: Zajac AJ; Blattman JN; Murali-Krishna K; Sourdive DJ; Suresh M; Altman JD; Ahmed R
  • Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b).
    J Exp Med Volume: 188 Page(s): 1841 - 1848
    11/16/1998 Authors: Vance RE; Kraft JR; Altman JD; Jensen PE; Raulet DH
  • Characteristics of virus-specific CD8(+) T cells in the liver during the control and resolution phases of influenza pneumonia.
    Proc Natl Acad Sci U S A Volume: 95 Page(s): 13812 - 13817
    11/10/1998 Authors: Belz GT; Altman JD; Doherty PC
  • Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected].
    Immunity Volume: 9 Page(s): 459 - 466
    10/01/1998 Authors: Boniface JJ; Rabinowitz JD; Wlfing C; Hampl J; Reich Z; Altman JD; Kantor RM; Beeson C; McConnell HM; Davis MM
  • Divergent IFN-alpha/beta- and IL-12-mediated pathways supporting protective T cell responses to lymphocytic choriomeningitis infections.
    EUROPEAN CYTOKINE NETWORK Volume: 9 Page(s): 350 - 350
    09/01/1998 Authors: Cousens LP; Altman JD; Dorner A; Ahmed R; Biron CA
  • Individual variations in the murine T cell response to a specific peptide reflect variability in naive repertoires.
    Immunity Volume: 9 Page(s): 169 - 178
    08/01/1998 Authors: Bousso P; Casrouge A; Altman JD; Haury M; Kanellopoulos J; Abastado JP; Kourilsky P
  • Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection.
    J Exp Med Volume: 188 Page(s): 71 - 82
    07/06/1998 Authors: Sourdive DJ; Murali-Krishna K; Altman JD; Zajac AJ; Whitmire JK; Pannetier C; Kourilsky P; Evavold B; Sette A; Ahmed R
  • Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen.
    Immunity Volume: 8 Page(s): 667 - 673
    06/01/1998 Authors: Gtgemann I; Fahrer AM; Altman JD; Davis MM; Chien YH
  • Virus-specific CD8+ T cells in primary and secondary influenza pneumonia.
    Immunity Volume: 8 Page(s): 683 - 691
    06/01/1998 Authors: Flynn KJ; Belz GT; Altman JD; Ahmed R; Woodland DL; Doherty PC
  • Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.
    Immunity Volume: 8 Page(s): 177 - 187
    02/01/1998 Authors: Murali-Krishna K; Altman JD; Suresh M; Sourdive DJ; Zajac AJ; Miller JD; Slansky J; Ahmed R
  • In vivo dynamics of anti-viral CD8 T cell responses to different epitopes. An evaluation of bystander activation in primary and secondary responses to viral infection.
    Adv Exp Med Biol Volume: 452 Page(s): 123 - 142
    01/01/1998 Authors: Murali-Krishna K; Altman JD; Suresh M; Sourdive D; Zajac A; Ahmed R
  • The recognition of the nonclassical major histocompatibility complex (MHC) class I molecule, T10, by the gammadelta T cell, G8.
    J Exp Med Volume: 185 Page(s): 1223 - 1230
    04/07/1997 Authors: Crowley MP; Reich Z; Mavaddat N; Altman JD; Chien Y
  • Stability of empty and peptide-loaded class II major histocompatibility complex molecules at neutral and endosomal pH: comparison to class I proteins.
    Proc Natl Acad Sci U S A Volume: 94 Page(s): 2495 - 2500
    03/18/1997 Authors: Reich Z; Altman JD; Boniface JJ; Lyons DS; Kozono H; Ogg G; Morgan C; Davis MM
  • T cell receptor biochemistry, repertoire selection and general features of TCR and Ig structure.
    Ciba Found Symp Volume: 204 Page(s): 94 - 100
    01/01/1997 Authors: Davis MM; Lyons DS; Altman JD; McHeyzer-Williams M; Hampl J; Boniface JJ; Chien Y
  • Biological and chemical aspects of T-cell receptor-mediated recognition
    Volume: 40 Page(s): 193 - 203
    01/01/1997 Authors: Davis MM; Lyons DS; Altman JD; Hampl J; Boniface JJ; Arden B; Chien Y
  • Phenotypic analysis of antigen-specific T lymphocytes.
    Science Volume: 274 Page(s): 94 - 96
    10/04/1996 Authors: Altman JD; Moss PA; Goulder PJ; Barouch DH; McHeyzer-Williams MG; Bell JI; McMichael AJ; Davis MM
  • Direct visualisation and phenotyping or HIV-specific T cells in blood of infected patients
    BRITISH JOURNAL OF HAEMATOLOGY Volume: 93 Page(s): 1185 - 1185
    06/01/1996 Authors: Moss PAH; Altman J; Goulder P; McMichael A; Davis M; Bell J
  • Enumeration and characterization of memory cells in the TH compartment.
    Immunol Rev Volume: 150 Page(s): 5 - 21
    04/01/1996 Authors: McHeyzer-Williams MG; Altman JD; Davis MM
  • Tracking antigen-specific helper T cell responses.
    Curr Opin Immunol Volume: 8 Page(s): 278 - 284
    04/01/1996 Authors: McHeyzer-Williams MG; Altman JD; Davis MM
  • Direct visualisation and phenotyping of HIV-specific T cells in blood of infected patients
    BRITISH JOURNAL OF HAEMATOLOGY Volume: 93 Page(s): 56 - 56
    04/01/1996 Authors: Moss PAH; Altman J; Goulder P; McMichael A; Davis M; Bell J
  • STAINING OF ANTIGEN-SPECIFIC T-CELLS WITH MULTIMERIZED CLASS-II MHC MOLECULES
    JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 87 - 87
    03/10/1995 Authors: ALTMAN J; MCHEYZERWILLIAMS M; FUKUI Y; BONIFACE J; DAVIS M
  • IN-VITRO FOLDING OF MHC CLASS-II HETEORDIMERS IN THE ABSENCE OF A PEPTIDE
    JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 288 - 288
    01/01/1994 Authors: ALTMAN JD; DAVIS MM
  • Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli.
    Proc Natl Acad Sci U S A Volume: 90 Page(s): 10330 - 10334
    11/01/1993 Authors: Altman JD; Reay PA; Davis MM
  • Two-dimensional nuclear magnetic resonance analysis of a labeled peptide bound to a class II major histocompatibility complex molecule.
    J Mol Biol Volume: 232 Page(s): 342 - 350
    07/20/1993 Authors: Driscoll PC; Altman JD; Boniface JJ; Sakaguchi K; Reay PA; Omichinski JG; Appella E; Davis MM
  • NUCLEAR-MAGNETIC-RESONANCE STUDIES OF A SOLUBLE CLASS-II MHC PEPTIDE COMPLEX
    JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 215 - 215
    02/08/1993 Authors: DRISCOLL PC; SAKAGUCHI K; OMISCHINSKI JG; APPELLA E; BONIFACE JJ; ALTMAN J; DAVIS MM
  • RECONSTITUTION OF SPECIFIC PEPTIDE BINDING AND T-CELL RECOGNITION OF CLASS-II I-EK HETERODIMERS FROM SUBUNITS PRODUCED IN ESCHERICHIA-COLI
    JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 89 - 89
    02/08/1993 Authors: ALTMAN JD; REAY PA; DAVIS MM
  • Intracellular expression of BPTI fusion proteins and single column cleavage/affinity purification by chymotrypsin.
    Protein Eng Volume: 4 Page(s): 593 - 600
    06/01/1991 Authors: Altman JD; Henner D; Nilsson B; Anderson S; Kuntz ID
  • Structural studies of cytochrome b5: complete sequence-specific resonance assignments for the trypsin-solubilized microsomal ferrocytochrome b5 obtained from pig and calf.
    Biochemistry Volume: 29 Page(s): 1276 - 1289
    02/06/1990 Authors: Guiles RD; Altman J; Kuntz ID; Waskell L; Lipka JJ
  • Identification by proton nuclear magnetic resonance of the histidines in cytochrome b5 modified by diethyl pyrocarbonate.
    Biochemistry Volume: 28 Page(s): 7516 - 7523
    09/19/1989 Authors: Altman J; Lipka JJ; Kuntz I; Waskell L
  • STRUCTURAL STUDIES OF A SYNTHETIC HEPTADECAPEPTIDE DESIGNED AS A MONOMERIC HELIX IN SOLUTION
    JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 231 - 231
    01/01/1987 Authors: THOMASON JF; BRADLEY EK; ALTMAN JD; SCHEEK RM; KUNTZ ID
  • Stimulation of in vitro human skin collagenase expression by platelet-derived growth factor.
    Proc Natl Acad Sci U S A Volume: 82 Page(s): 4132 - 4136
    06/01/1985 Authors: Bauer EA; Cooper TW; Huang JS; Altman J; Deuel TF
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