Publications

• Contractility and Calcium Transient Maturation in the Human iPSC-Derived Cardiac Microfibers.
  ACS Appl Mater Interfaces Volume: 14 Page(s): 35376 - 35388
  08/10/2022 Authors: Strimaityte D; Tu C; Yanez A; Itzhaki I; Wu H; Wu JC; Yang H
• Transcriptome analysis of non human primate-induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer culture vs. 3D engineered heart tissue.
  Cardiovasc Res Volume: 117 Page(s): 2125 - 2136
  07/27/2021 Authors: Yang H; Shao N; Holmstrm A; Zhao X; Chour T; Chen H; Itzhaki I; Wu H; Ameen M; Cunningham NJ
• Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies.
  JCI Insight Volume: 6
  04/08/2021 Authors: Chour T; Tian L; Lau E; Thomas D; Itzhaki I; Malak O; Zhang JZ; Qin X; Wardak M; Liu Y
• RNA Sequencing Analysis of Induced Pluripotent Stem Cell-Derived Cardiomyocytes From Congenital Heart Disease Patients.
  Circ Res Volume: 126 Page(s): 923 - 925
  03/27/2020 Authors: Kitani T; Tian L; Zhang T; Itzhaki I; Zhang JZ; Ma N; Liu C; Rhee J-W; Romfh AW; Lui GK
• Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
  Nature Volume: 572 Page(s): 335 - 340
  08/01/2019 Authors: Lee J; Termglinchan V; Diecke S; Itzhaki I; Lam CK; Garg P; Lau E; Greenhaw M; Seeger T; Wu H
• A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.
  Cell Stem Cell Volume: 24 Page(s): 802 - 811.e5
  05/02/2019 Authors: Zhang JZ; Termglinchan V; Shao N-Y; Itzhaki I; Liu C; Ma N; Tian L; Wang VY; Chang ACY; Guo H
• Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells.
  Circulation Volume: 138 Page(s): 2666 - 2681
  12/04/2018 Authors: Ma N; Zhang JZ; Itzhaki I; Zhang SL; Chen H; Haddad F; Kitani T; Wilson KD; Tian L; Shrestha R
• Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction.
  Stem Cell Reports Volume: 10 Page(s): 422 - 435
  02/13/2018 Authors: Zhao X; Chen H; Xiao D; Yang H; Itzhaki I; Qin X; Chour T; Aguirre A; Lehmann K; Kim Y
• A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases.
  Circ Res Volume: 120 Page(s): 1561 - 1571
  05/12/2017 Authors: Karakikes I; Termglinchan V; Cepeda DA; Lee J; Diecke S; Hendel A; Itzhaki I; Ameen M; Shrestha R; Wu H
• Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome.
  J Am Coll Cardiol Volume: 68 Page(s): 2086 - 2096
  11/08/2016 Authors: Liang P; Sallam K; Wu H; Li Y; Itzhaki I; Garg P; Zhang Y; Vermglinchan V; Lan F; Gu M
• Modeling of catecholaminergic polymorphic ventricular tachycardia with patient-specific human-induced pluripotent stem cells.
  J Am Coll Cardiol Volume: 60 Page(s): 990 - 1000
  09/11/2012 Authors: Itzhaki I; Maizels L; Huber I; Gepstein A; Arbel G; Caspi O; Miller L; Belhassen B; Nof E; Glikson M
• Calcium handling in human induced pluripotent stem cell derived cardiomyocytes.
  PLoS One Volume: 6 Page(s): e18037
  04/01/2011 Authors: Itzhaki I; Rapoport S; Huber I; Mizrahi I; Zwi-Dantsis L; Arbel G; Schiller J; Gepstein L
• Modelling the long QT syndrome with induced pluripotent stem cells.
  Nature Volume: 471 Page(s): 225 - 229
  03/10/2011 Authors: Itzhaki I; Maizels L; Huber I; Zwi-Dantsis L; Caspi O; Winterstern A; Feldman O; Gepstein A; Arbel G; Hammerman H
• A combined gene and cell therapy approach for restoration of conduction.
  Heart Rhythm Volume: 8 Page(s): 121 - 130
  01/01/2011 Authors: Hofshi A; Itzhaki I; Gepstein A; Arbel G; Gross GJ; Gepstein L
• In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes.
  Stem Cells Dev Volume: 18 Page(s): 161 - 172
  01/01/2009 Authors: Caspi O; Itzhaki I; Kehat I; Gepstein A; Arbel G; Huber I; Satin J; Gepstein L
• Calcium handling in human embryonic stem cell-derived cardiomyocytes.
  Stem Cells Volume: 26 Page(s): 1961 - 1972
  08/01/2008 Authors: Satin J; Itzhaki I; Rapoport S; Schroder EA; Izu L; Arbel G; Beyar R; Balke CW; Schiller J; Gepstein L
• Cell therapy for modification of the myocardial electrophysiological substrate.
  Circulation Volume: 117 Page(s): 720 - 731
  02/12/2008 Authors: Yankelson L; Feld Y; Bressler-Stramer T; Itzhaki I; Huber I; Gepstein A; Aronson D; Marom S; Gepstein L
• Identification and selection of cardiomyocytes during human embryonic stem cell differentiation.
  FASEB J Volume: 21 Page(s): 2551 - 2563
  08/01/2007 Authors: Huber I; Itzhaki I; Caspi O; Arbel G; Tzukerman M; Gepstein A; Habib M; Yankelson L; Kehat I; Gepstein L
• Calcium handling in embryonic stem cell-derived cardiac myocytes: of mice and men.
  Volume: 1080 Page(s): 207 - 215
  10/01/2006 Authors: Itzhaki I; Schiller J; Beyar R; Satin J; Gepstein L
• Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes.
  J Physiol Volume: 559 Page(s): 479 - 496
  09/01/2004 Authors: Satin J; Kehat I; Caspi O; Huber I; Arbel G; Itzhaki I; Magyar J; Schroder EA; Perlman I; Gepstein L