Inyeong Choi PhD

Department of Cell Biology
Associate Professor

Academic Appointment

Associate Professor, Department of Physiology, Emory

Education

Degrees

PhD from University of Wisconsin
BA from Korea University
M.S. from University of Minnesota

Research

Focus

Research focuses predominantly in 3 areas:
1) Physiology and pathophysiology of acid base regulation in the brain and kidneys. 2) Developing an animal model of alcoholic ketoacidosis. 3) Role of abnormal pH regulation in prostate cancer growth.

Publications

Sodium Bicarbonate Decreases Alcohol Consumption in Mice.
Int J Mol Sci Volume: 25
05/03/2024 Authors: Lin J; Rivadeneira AP; Ye Y; Ryu C; Parvin S; Jang K; Garraway SM; Choi I
The ion binding site in transmembrane domain 5 of NBCe1 has negligible role in electrogenicity.
FASEB J Volume: 36 Suppl 1
05/01/2022 Authors: Choi I; Lee S
Bicarbonate-Independent Sodium Conductance of Na/HCO3 Cotransporter NBCn1 Decreases NMDA Receptor Function.
Curr Issues Mol Biol Volume: 44 Page(s): 1284 - 1293
03/13/2022 Authors: Choi I; Yang H; Kim E; Lee S
Lack of Charge Interaction in the Ion Binding Site Determines Anion Selectivity in the Sodium Bicarbonate Cotransporter NBCe1.
Int J Mol Sci Volume: 23
01/04/2022 Authors: Lee S; Lin J; Choi I
Decreased Brain pH and Pathophysiology in Schizophrenia.
Int J Mol Sci Volume: 22
08/04/2021 Authors: Park H-J; Choi I; Leem K-H
Sodium bicarbonate transporter NBCe1 regulates proliferation and viability of human prostate cancer cells LNCaP and PC3.
Oncol Rep Volume: 46
07/01/2021 Authors: Li JM; Lee S; Zafar R; Shin E; Choi I
Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice.
Behav Brain Res Volume: 401 Page(s): 113065
03/05/2021 Authors: Choi I; Beedholm K; Dam VS; Bae S-H; Noble DJ; Garraway SM; Aalkjaer C; Boedtkjer E
Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1.
Sci Rep Volume: 10 Page(s): 11017
07/03/2020 Authors: Schank JR; Lee S; Gonzalez-Islas CE; Nennig SE; Fulenwider HD; Chang J; Li JM; Kim Y; Jeffers LA; Chung J
Deletion of the Na/HCO3 Transporter NBCn1 Protects Hippocampal Neurons from NMDA-induced Seizures and Neurotoxicity in Mice.
Sci Rep Volume: 9 Page(s): 15981
11/05/2019 Authors: Park HJ; Gonzalez-Islas CE; Kang Y; Li JM; Choi I
4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances Kv 7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries.
Br J Pharmacol Volume: 175 Page(s): 501 - 516
02/01/2018 Authors: Khammy MM; Kim S; Bentzen BH; Lee S; Choi I; Aalkjaer C; Jepps TA
Evidence for ammonium conductance in a mouse thick ascending limb cell line.
Physiol Rep Volume: 5
08/01/2017 Authors: Lee S; Park J; Li JM; Li K; Choi I
Ammonium Conductance in a Mouse Thick Ascending Limb Cell Line
Volume: 31
04/01/2017 Authors: Lee S; Park J; Choi I
Alternative transcription of sodium/bicarbonate transporter SLC4A7 gene enhanced by single nucleotide polymorphisms.
Physiol Genomics Volume: 49 Page(s): 167 - 176
03/01/2017 Authors: Park HJ; Lee S; Ju E; Jones JA; Choi I
Cation-coupled bicarbonate transporters.
Compr Physiol Volume: 4 Page(s): 1605 - 1637
10/01/2014 Authors: Aalkjaer C; Boedtkjer E; Choi I; Lee S
Systematic family-wide analysis of sodium bicarbonate cotransporter NBCn1/SLC4A7 interactions with PDZ scaffold proteins.
Physiol Rep Volume: 2
05/01/2014 Authors: Lee HJ; Kwon MH; Lee S; Hall RA; Yun CC; Choi I
PSD-95 interacts with NBCn1 and enhances channel-like activity without affecting cotransport function
Volume: 27
04/01/2013 Authors: Lee S; Choi I
Electrogenicity and Anion Selectivity of the Sodium/Bicarbonate Transporter NBCe1 Determined by a Single Mechanism
Volume: 26
04/01/2012 Authors: Lee S; Choi I
SLC4A transporters.
Curr Top Membr Volume: 70 Page(s): 77 - 103
01/01/2012 Authors: Choi I
PSD-95 interacts with NBCn1 and enhances channel-like activity without affecting Na/HCO(3) cotransport.
Cell Physiol Biochem Volume: 30 Page(s): 1444 - 1455
01/01/2012 Authors: Lee S; Yang HS; Kim E; Ju EJ; Kwon MH; Dudley RK; Smith Y; Yun CC; Choi I
Sodium-bicarbonate cotransporter NBCn1/Slc4a7 inhibits NH4Cl-mediated inward current in Xenopus oocytes.
Exp Physiol Volume: 96 Page(s): 745 - 755
08/01/2011 Authors: Lee S; Choi I
Sodium/Bicarbonate Transporter NBCn1 (SLC4A7) Reduces Ammonium Transport
Volume: 25
04/01/2011 Authors: Lee S; Choi I
The sodium-driven chloride/bicarbonate exchanger NDCBE in rat brain is upregulated by chronic metabolic acidosis.
Brain Res Volume: 1377 Page(s): 13 - 20
03/04/2011 Authors: Lee HJ; Park HJ; Lee S; Kim YH; Choi I
Evaluation of an intraperitoneal ovarian cancer syngeneic mouse model using 18F-FDG MicroPET imaging.
Int J Gynecol Cancer Volume: 21 Page(s): 22 - 27
01/01/2011 Authors: Lee HJ; Tantawy MN; Nam KT; Choi I; Peterson TE; Price RR
Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages.
J Biol Chem Volume: 285 Page(s): 39655 - 39662
12/17/2010 Authors: Lee HJ; Joo M; Abdolrasulnia R; Young DG; Choi I; Ware LB; Blackwell TS; Christman BW
Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport.
Exp Physiol Volume: 95 Page(s): 926 - 937
09/01/2010 Authors: Lee S; Lee HJ; Yang HS; Thornell IM; Bevensee MO; Choi I
Neuronal expression of sodium/bicarbonate cotransporter NBCn1 (SLC4A7) and its response to chronic metabolic acidosis.
Am J Physiol Cell Physiol Volume: 298 Page(s): C1018 - C1028
05/01/2010 Authors: Park HJ; Rajbhandari I; Yang HS; Lee S; Cucoranu D; Cooper DS; Klein JD; Sands JM; Choi I
Na/Bicarbonate Cotransporter NBCn1 is Upregulated under Acidic Conditions and Enhances Ammonium Transport in the Kidney Medullary Thick Ascending Limb Cell Line
FASEB JOURNAL Volume: 24
04/01/2010 Authors: Lee S; Lee HJ; Park HJ; Yang HS; Cucoranu D; Rajbhandari I; Cooper DS; Choi I
Inhibition of seizure-induced cell death by sodium/bicarbonate cotransporter NBCn1 (SLC4A7)
FASEB JOURNAL Volume: 24
04/01/2010 Authors: Park HJ; Choi I
Ion translocation via the transmembrane domain 5 in the sodium/bicarbonate transporter NBCe1
FASEB JOURNAL Volume: 24
04/01/2010 Authors: Lee S; Choi I
Inhibition of rat Na+(-)HCO3(-) cotransporter (NBCn1) function and expression by the alternative splice domain.
Exp Physiol Volume: 94 Page(s): 1114 - 1123
11/01/2009 Authors: Yang HS; Cooper DS; Rajbhandari I; Park HJ; Lee S; Choi I
Mutation of Aspartate 555 of the Sodium/Bicarbonate Transporter SLC4A4/NBCe1 Induces Chloride Transport.
J Biol Chem Volume: 284 Page(s): 15970 - 15979
06/05/2009 Authors: Yang HS; Kim E; Lee S; Park HJ; Cooper DS; Rajbhandari I; Choi I
Localization of Na/HCO3 cotransporter NBCn1 (SLC4A7) in rat hippocampus
FASEB JOURNAL Volume: 23
04/01/2009 Authors: Park HJ; Rajbhandari I; Choi I
Chloride transport induced by the substitution of Asp555 with a Glu in the Na/HCO3 cotransporter SLC4A4 (NBCe1)
FASEB JOURNAL Volume: 23
04/01/2009 Authors: Lee S; Yang HS; Nichols JW; Rajbhandari I; Choi I
Sodium/bicarbonate cotransporter NBCn1/slc4a7 increases cytotoxicity in magnesium depletion in primary cultures of hippocampal neurons.
Eur J Neurosci Volume: 29 Page(s): 437 - 446
02/01/2009 Authors: Cooper DS; Yang HS; He P; Kim E; Rajbhandari I; Yun CC; Choi I
Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity.
J Biol Chem Volume: 283 Page(s): 12777 - 12788
05/09/2008 Authors: Parker MD; Musa-Aziz R; Rojas JD; Choi I; Daly CM; Boron WF
The conductance properties of Asp(555) in the electrogenic Na/HCO3 cotransporter SLC4A4/NBCe1
FASEB JOURNAL Volume: 22
04/01/2008 Authors: Kim E; Choi I
Interaction of the Na/HCO3 cotransporter SLC4A7 (NBCn1) and the N-Methyl-D-Aspartate (NMDA) receptor subunit NR2A
FASEB JOURNAL Volume: 22
04/01/2008 Authors: Rajbhandari I; Kim E; Choi I
Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain.
Am J Physiol Regul Integr Comp Physiol Volume: 293 Page(s): R2412 - R2420
12/01/2007 Authors: Chen L-M; Choi I; Haddad GG; Boron WF
Cloning and characterization of an electrogenic Na/HCO3- cotransporter from the squid giant fiber lobe.
Am J Physiol Cell Physiol Volume: 292 Page(s): C2032 - C2045
06/01/2007 Authors: Piermarini PM; Choi I; Boron WF
The electrogenicity of the rat sodium-bicarbonate cotransporter NBCe1 requires interactions among transmembrane segments of the transporter.
J Physiol Volume: 578 Page(s): 131 - 142
01/01/2007 Authors: Choi I; Soo Yang H; Boron WF
The electroneutral sodium/bicarbonate cotransporter containing an amino terminal 123-amino-acid cassette is expressed predominantly in the heart.
J Biomed Sci Volume: 13 Page(s): 593 - 595
07/01/2006 Authors: Cooper DS; Lee HJ; Yang HS; Kippen J; Yun CC; Choi I
Cloning of a unique electrogenic bicarbonate transporter from the squid giant fiber lobe
Volume: 20 Page(s): A842 - A842
03/07/2006 Authors: Piermarini PM; Choi I; Boron WF
Coexpression of MAST205 inhibits the activity of Na+/H+ exchanger NHE3.
Am J Physiol Renal Physiol Volume: 290 Page(s): F428 - F437
02/01/2006 Authors: Wang D; Lee HJ; Cooper DS; Cebotaro L; Walden PD; Choi I; Yun CC
Molecular and functional characterization of the electroneutral Na/HCO3 cotransporter NBCn1 in rat hippocampal neurons.
J Biol Chem Volume: 280 Page(s): 17823 - 17830
05/06/2005 Authors: Cooper DS; Saxena NC; Yang HS; Lee HJ; Moring AG; Lee A; Choi I
Molecular and functional role of the electroneutral sodium bicarbonate cotransporter in thick ascending limb
Volume: 45 Page(s): A22 - A22
04/01/2005 Authors: Choi I; Cooper DS
Quantitative measurements of the electroneutral Na/bicarbonate cotransporter (NBCn1) expression in chronic metabolic acidosis
Volume: 18 Page(s): A1018 - A1018
03/24/2004 Authors: Cucoranu D; Cooper DS; Shyntum DY; Chen GP; Klein JD; Sands JM; Choi I
Cloning of a Na+-driven Cl/HCO3 exchanger from squid giant fiber lobe.
Am J Physiol Cell Physiol Volume: 285 Page(s): C771 - C780
10/01/2003 Authors: Virkki LV; Choi I; Davis BA; Boron WF
Role of glycosylation in the renal electrogenic Na+-HCO3- cotransporter (NBCe1).
Am J Physiol Renal Physiol Volume: 284 Page(s): F1199 - F1206
06/01/2003 Authors: Choi I; Hu L; Rojas JD; Schmitt BM; Boron WF
The effect of mutations of K559 and K562, within the KMIK motif of TM5, on the DIDS sensitivity of the electrogenic Na/HCO3 cotransporter from human kidney (hNBCel-A)
Volume: 17 Page(s): A1221 - A1221
03/17/2003 Authors: Lu J; Virkki L; Choi I; Boulpaep EL; Boron WF
Functional characterization of "NCBE", a Na/HCO3 cotransporter
FASEB JOURNAL Volume: 16 Page(s): A796 - A796
03/22/2002 Authors: Choi I; Rojas JD; Kobayashi C; Boron WF
Na+-dependent Cl-HCO3 exchanger: Cloning, tissue distribution & characterization.
AMERICAN JOURNAL OF KIDNEY DISEASES Volume: 37 Page(s): A17 - A17
04/01/2001 Authors: Grichtchenko II; Choi I; Russell JM; Boron WF
Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger.
J Biol Chem Volume: 276 Page(s): 8358 - 8363
03/16/2001 Authors: Grichtchenko II; Choi I; Zhong X; Bray-Ward P; Russell JM; Boron WF
Molecular cloning of an electroneutral Na+ and Cl- -dependent HCO3- transporter from squid (Loligo pealei and Loligo opalescens) giant fiber lobe.
FASEB JOURNAL Volume: 15 Page(s): A446 - A446
03/07/2001 Authors: Virkki LV; Choi I; Davis BA; Somieski P; Franke C; Boron WF
Immunoelectron microscopic localization of the electrogenic Na/HCO(3) cotransporter in rat and ambystoma kidney.
J Am Soc Nephrol Volume: 11 Page(s): 2179 - 2189
12/01/2000 Authors: Maunsbach AB; Vorum H; Kwon T-H; Nielsen S; Simonsen B; Choi I; Schmitt BM; Boron WF; AALKJR C
Immunolocalization of electroneutral Na-HCO(3)(-) cotransporter in rat kidney.
Am J Physiol Renal Physiol Volume: 279 Page(s): F901 - F909
11/01/2000 Authors: Vorum H; Kwon TH; Fulton C; Simonsen B; Choi I; Boron W; Maunsbach AB; Nielsen S; Aalkjaer C
Loss of cell viability by histidine substitution of leucine 325 of the glutamate transporter EAAT1.
Biochem Biophys Res Commun Volume: 275 Page(s): 382 - 385
08/28/2000 Authors: Choi I; Chiu SY
An electrogenic Na(+)-HCO(-)(3) cotransporter (NBC) with a novel COOH-terminus, cloned from rat brain.
Am J Physiol Cell Physiol Volume: 278 Page(s): C1200 - C1211
06/01/2000 Authors: Bevensee MO; Schmitt BM; Choi I; Romero MF; Boron WF
An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel.
Nature Volume: 405 Page(s): 571 - 575
06/01/2000 Authors: Choi I; Aalkjaer C; Boulpaep EL; Boron WF
Functional characterization of an electroneutral Na/HCO3 cotransporter (NBCn1).
FASEB JOURNAL Volume: 14 Page(s): A356 - A356
03/15/2000 Authors: Choi I; Boulpaep EL; Boron WF
Electroneutral Na,HCO3-cotransport (enNBC) in rat seminiferous tubules.
FASEB JOURNAL Volume: 14 Page(s): A356 - A356
03/15/2000 Authors: Aalkiaer C; Fulton C; Kwan T; Nielsen S; Choi I; Boron W; Vorum H
Cloning and characterization of an electroneutral Na-driven bicarbonate transporter from rat pulmonary arteries.
FASEB JOURNAL Volume: 13 Page(s): A400 - A400
03/12/1999 Authors: Choi I; Aalkjaer C; Romero MF; Boron WF
Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC).
Am J Physiol Volume: 276 Page(s): C576 - C584
03/01/1999 Authors: Choi I; Romero MF; Khandoudi N; Bril A; Boron WF
Expression of high-affinity neuronal and glial glutamate transporters in the rat optic nerve.
Glia Volume: 20 Page(s): 184 - 192
07/01/1997 Authors: Choi I; Chiu SY
Abolition of substrate-dependent currents by tyrosine mutation in the transmembrane domain of glutamate transporter.
FEBS Lett Volume: 405 Page(s): 133 - 136
03/24/1997 Authors: Choi I; Chiu SY

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Profile

Inyeong Choi PhD

Academic Appointment

Education

Degrees

Research

Focus

Research focuses predominantly in 3 areas:

Publications