Hongjie Yuan MD, PhD
- Department of Pharmacology & Chemical Biology
Associate Professor
- (404) 727-1375
- hyuan@emory.edu
- My Lab
- My ResearchGate
- My Google Scholar
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Emory University School of Medicine
Pharmacology
1510 Clifton Rd NE, Room 5015
Overview
My current research is focused on human glutamate receptor (NMDAR) mutations associated with neurological and neuropsychiatric disorders. We are utilizing a multidisciplinary approach that combines clinical experience, training in electrophysiology, and understanding of neurophysiology to translate basic research involving human glutamate receptor mutations toward therapeutic use.
Academic Appointment
- Associate Professor, Department of Pharmacology and Chemical Biology, Emory University School of Medicine
Education
Degrees
- MD from BaoTou Medical School
- PhD from Akita University School of Medicine
- Master of Medicine from Norman Bethune University of Medical Sciences
Research
Focus
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Molecular Genetics and Neuroscience
My research program utilizes multidisciplinary approaches to translate basic research involving human glutamate receptor genetic variations toward understanding the functional consequences of the variants in neurological patients to catalyze the development of mechanistic hypotheses underlying certain neurological diseases, lay the groundwork for new treatment paradigms, and potentially improve clinical care.
Publications
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Selective enhancement of the interneuron network and gamma-band power via GluN2C/GluN2D NMDA receptor potentiation.
J Physiol
06/25/2025 Authors: Camp CR; Banke TG; Xing H; Yu K; Perszyk RE; Epplin MP; Akins NS; Zhang J; Benke TA; Yuan H -
Advances in the Structural Basis of GluN2A-Selective Negative Allosteric Modulators.
ACS Med Chem Lett Volume: 16 Page(s): 911 - 915
06/12/2025 Authors: Li Y; Yuan H; Liang SH -
Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy.
Brain
04/09/2025 Authors: Teoh J; Simko J; Camp CR; Liu CJ; Wang W; Williams D; Ma L; Soundararajan D; Martin C; Taylor NK -
Development of a Novel 18F-Labeled Radioligand for Imaging Cholesterol 24-Hydroxylase with Positron Emission Tomography.
ACS Pharmacol Transl Sci Volume: 8 Page(s): 800 - 807
03/14/2025 Authors: Rong J; Zhao C; Chaudhary AF; Chen J; Zhou X; Zhang K; Song Z; Sun Z; Gao Y; Zhang Z -
Development of a Novel 18F-Labeled Radioligand for Imaging Phosphodiesterase 7 with Positron Emission Tomography.
Mol Pharm Volume: 22 Page(s): 1657 - 1666
03/03/2025 Authors: Rong J; Zhao C; Chaudhary AF; Jones E; Van R; Song Z; Li Y; Chen J; Zhou X; Patel JS -
Discovery of 18F Labeled AZD5213 Derivatives as Novel Positron Emission Tomography (PET) Radioligands Targeting Histamine Subtype-3 Receptor.
Chembiochem Volume: 26 Page(s): e202400655
02/03/2025 Authors: Song Z; Li Y; Dahl K; Chaudhary A; Sun Z; Zhou X; Chen J; Gao Y; Rong J; Zhao C -
Ligand distances as key predictors of pathogenicity and function in NMDA receptors.
Hum Mol Genet Volume: 34 Page(s): 128 - 139
01/29/2025 Authors: Montanucci L; Brnger T; Bhattarai N; Boelmann CM; Kim S; Allen JP; Zhang J; Klckner C; Krey I; Fariselli P -
Preclinical Evaluation of [ 18 F]P4B-2412 as Phosphodiesterase 4B Radioligand for Positron Emission Tomography Imaging.
bioRxiv
01/16/2025 Authors: Song Z; Li Y; Feng S; Chen J; Zhou X; Zhang Z; Sun Z; Rong J; Zhao C; Chaudhary A -
Automatic synthesis of a phosphodiesterase 4B (PDE4B) radioligand and PET imaging in depression rodent models.
Am J Nucl Med Mol Imaging Volume: 15 Page(s): 55 - 64
01/01/2025 Authors: Dong C; Ye W; Xu Y; Chen J; Liao K; Wei H; Jiang Y; Hou L; Wei J; Tan Z -
Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors.
J Neurochem Volume: 168 Page(s): 3936 - 3949
12/01/2024 Authors: Song R; Zhang J; Perszyk RE; Camp CR; Tang W; Kannan V; Li J; Xu Y; Chen J; Li Y