Hongjie Yuan MD, PhD

Department of Pharmacology & Chemical Biology
Associate Professor

Emory University School of Medicine
Pharmacology
1510 Clifton Rd NE, Room 5015

Overview

My current research is focused on human glutamate receptor (NMDAR) mutations associated with neurological and neuropsychiatric disorders. We are utilizing a multidisciplinary approach that combines clinical experience, training in electrophysiology, and understanding of neurophysiology to translate basic research involving human glutamate receptor mutations toward therapeutic use.

Academic Appointment

Assistant Professor, Department of Pharmacology, Emory University School of Medicine

Education

Degrees

MD from BaoTou Medical School
PhD from Akita University School of Medicine
Master of Medicine from Norman Bethune University of Medical Sciences

Research

Focus

Molecular Genetics and Neuroscience
My research program utilizes multidisciplinary approaches to translate basic research involving human glutamate receptor genetic variations toward understanding the functional consequences of the variants in neurological patients to catalyze the development of mechanistic hypotheses underlying certain neurological diseases, lay the groundwork for new treatment paradigms, and potentially improve clinical care.

Publications

Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy.
Brain
04/09/2025 Authors: Teoh J; Simko J; Camp CR; Liu CJ; Wang W; Williams D; Ma L; Soundararajan D; Martin C; Taylor NK
Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors.
J Neurochem Volume: 168 Page(s): 3936 - 3949
12/01/2024 Authors: Song R; Zhang J; Perszyk RE; Camp CR; Tang W; Kannan V; Li J; Xu Y; Chen J; Li Y
Distances from ligands as main predictive features for pathogenicity and functional effect of variants in NMDA receptors.
medRxiv
05/07/2024 Authors: Montanucci L; Brnger T; Bhattarai N; Boelmann CM; Kim S; Allen JP; Zhang J; Klckner C; Fariselli P; May P
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.
Cell Mol Life Sci Volume: 81 Page(s): 153
03/28/2024 Authors: Xu Y; Song R; Perszyk RE; Chen W; Kim S; Park KL; Allen JP; Nocilla KA; Zhang J; XiangWei W
Preclinical Evaluation of Azabenzimidazole-Based PET Radioligands for -8 Dependent Transmembrane AMPA Receptor Regulatory Protein Imaging.
Chembiochem Volume: 25 Page(s): e202300813
03/15/2024 Authors: Chen J; Li Y; Yu Q; Patel JS; Zhou X; Zhang K; Rong J; Zhao C; Chaudhary AF; Zhang W
Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.
Hum Mol Genet Volume: 33 Page(s): 355 - 373
02/01/2024 Authors: Allen JP; Garber KB; Perszyk R; Khayat CT; Kell SA; Kaneko M; Quindipan C; Saitta S; Ladda RL; Hewson S
Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry.
Neuropsychopharmacology Volume: 49 Page(s): 51 - 66
01/01/2024 Authors: Hanson JE; Yuan H; Perszyk RE; Banke TG; Xing H; Tsai M-C; Menniti FS; Traynelis SF
Clinical and functional consequences of GRIA variants in patients with neurological diseases.
Cell Mol Life Sci Volume: 80 Page(s): 345
11/03/2023 Authors: XiangWei W; Perszyk RE; Liu N; Xu Y; Bhattacharya S; Shaulsky GH; Smith-Hicks C; Fatemi A; Fry AE; Chandler K
De novo CLPTM1 variants with reduced GABAA R current response in patients with epilepsy.
Epilepsia Volume: 64 Page(s): 2968 - 2981
11/01/2023 Authors: Liu N; Li J; Gao K; Perszyk RE; Zhang J; Wang J; Wu Y; Jenkins A; Yuan H; Traynelis SF
Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons.
Commun Biol Volume: 6 Page(s): 952
09/19/2023 Authors: Camp CR; Vlachos A; Klckner C; Krey I; Banke TG; Shariatzadeh N; Ruggiero SM; Galer P; Park KL; Caccavano A
Classification of missense variants in the N-methyl-d-aspartate receptor GRIN gene family as gain- or loss-of-function.
Hum Mol Genet Volume: 32 Page(s): 2857 - 2871
09/16/2023 Authors: Myers SJ; Yuan H; Perszyk RE; Zhang J; Kim S; Nocilla KA; Allen JP; Bain JM; Lemke JR; Lal D
Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor.
ACS Chem Neurosci Volume: 14 Page(s): 3059 - 3076
09/06/2023 Authors: D'Erasmo MP; Akins NS; Ma P; Jing Y; Swanger SA; Sharma SK; Bartsch PW; Menaldino DS; Arcoria PJ; Bui T-T
Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening.
Cell Mol Life Sci Volume: 80 Page(s): 110
03/31/2023 Authors: Xie L; McDaniel MJ; Perszyk RE; Kim S; Cappuccio G; Shapiro KA; Muoz-Cabello B; Sanchez-Lara PA; Grand K; Zhang J
Overlapping cortical malformations in patients with pathogenic variants in GRIN1 and GRIN2B.
J Med Genet Volume: 60 Page(s): 183 - 192
02/01/2023 Authors: Brock S; Laquerriere A; Marguet F; Myers SJ; Hongjie Y; Baralle D; Vanderhasselt T; Stouffs K; Keymolen K; Kim S
Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions.
Cell Mol Life Sci Volume: 80 Page(s): 42
01/16/2023 Authors: Tang W; Beckley JT; Zhang J; Song R; Xu Y; Kim S; Quirk MC; Robichaud AJ; Diaz ES; Myers SJ
Opportunities for Precision Treatment of GRIN2A and GRIN2B Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors.
J Pharmacol Exp Ther Volume: 381 Page(s): 54 - 66
04/01/2022 Authors: Han W; Yuan H; Allen JP; Kim S; Shaulsky GH; Perszyk RE; Traynelis SF; Myers SJ
Clinical and therapeutic significance of genetic variation in the GRIN gene family encoding NMDARs.
Neuropharmacology Volume: 199 Page(s): 108805
11/01/2021 Authors: Benke TA; Park K; Krey I; Camp CR; Song R; Ramsey AJ; Yuan H; Traynelis SF; Lemke J
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Pharmacol Rev Volume: 73 Page(s): 298 - 487
10/01/2021 Authors: Hansen KB; Wollmuth LP; Bowie D; Furukawa H; Menniti FS; Sobolevsky AI; Swanson GT; Swanger SA; Greger IH; Nakagawa T
Recurrent seizure-related GRIN1 variant: Molecular mechanism and targeted therapy.
Ann Clin Transl Neurol Volume: 8 Page(s): 1480 - 1494
07/01/2021 Authors: Xu Y; Song R; Chen W; Strong K; Shrey D; Gedela S; Traynelis SF; Zhang G; Yuan H
The Negative Allosteric Modulator EU1794-4 Reduces Single-Channel Conductance and Ca2+ Permeability of GluN1/GluN2A N-Methyl-d-Aspartate Receptors.
Mol Pharmacol Volume: 99 Page(s): 399 - 411
05/01/2021 Authors: Perszyk RE; Zheng Z; Banke TG; Zhang J; Xie L; McDaniel MJ; Katzman BM; Pelly SC; Yuan H; Liotta DC
A de novo GRIN1 Variant Associated With Myoclonus and Developmental Delay: From Molecular Mechanism to Rescue Pharmacology.
Front Genet Volume: 12 Page(s): 694312
01/01/2021 Authors: Zhang J; Tang W; Bhatia NK; Xu Y; Paudyal N; Liu D; Kim S; Song R; XiangWei W; Shaulsky G
Hodgkin-huxley-katz prize lecture: genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif (vol 598, pg 3071, 2020)
JOURNAL OF PHYSIOLOGY-LONDON Volume: 598 Page(s): 4995 - 4995
11/01/2020 Authors: Perszyk RE; Myers SJ; Yuan H; Gibb AJ; Furukawa H; Sobolevsky A; Traynelis SF
Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders.
Neuropharmacology Volume: 177 Page(s): 108247
10/15/2020 Authors: Tang W; Liu D; Traynelis SF; Yuan H
Negative allosteric modulation of GluN1/GluN3 NMDA receptors.
Neuropharmacology Volume: 176 Page(s): 108117
10/01/2020 Authors: Zhu Z; Yi F; Epplin MP; Liu D; Summer SL; Mizu R; Shaulsky G; XiangWei W; Tang W; Burger PB
Hodgkin-Huxley-Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif.
J Physiol Volume: 598 Page(s): 3071 - 3083
08/01/2020 Authors: Perszyk RE; Myers SJ; Yuan H; Gibb AJ; Furukawa H; Sobolevsky AI; Traynelis SF
The GRIA3 c.2477G >A Variant Causes an Exaggerated Startle Reflex, Chorea, and Multifocal Myoclonus.
Mov Disord Volume: 35 Page(s): 1224 - 1232
07/01/2020 Authors: Piard J; Breau M; XiangWei W; Wirth T; Amsallem D; Buisson L; Richard P; Liu N; Xu Y; Myers SJ
Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice.
Brain Volume: 143 Page(s): 2039 - 2057
07/01/2020 Authors: Amador A; Bostick CD; Olson H; Peters J; Camp CR; Krizay D; Chen W; Han W; Tang W; Kanber A
Biased modulators of NMDA receptors control channel opening and ion selectivity.
Nat Chem Biol Volume: 16 Page(s): 188 - 196
02/01/2020 Authors: Perszyk RE; Swanger SA; Shelley C; Khatri A; Fernandez-Cuervo G; Epplin MP; Zhang J; Le P; Blow P; Garnier-Amblard E
GRIN2D/GluN2D NMDA receptor: Unique features and its contribution to pediatric developmental and epileptic encephalopathy.
Eur J Paediatr Neurol Volume: 24 Page(s): 89 - 99
01/01/2020 Authors: Camp CR; Yuan H
De novo GRIN variants in NMDA receptor M2 channel pore-forming loop are associated with neurological diseases.
Hum Mutat Volume: 40 Page(s): 2393 - 2413
12/01/2019 Authors: Li J; Zhang J; Tang W; Mizu RK; Kusumoto H; XiangWei W; Xu Y; Chen W; Amin JB; Hu C
Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy.
Brain Volume: 142 Page(s): 3009 - 3027
10/01/2019 Authors: XiangWei W; Kannan V; Xu Y; Kosobucki GJ; Schulien AJ; Kusumoto H; Moufawad El Achkar C; Bhattacharya S; Lesca G; Nguyen S
Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain.
ACS Chem Neurosci Volume: 10 Page(s): 2263 - 2275
05/15/2019 Authors: Fu H; Tang W; Chen Z; Belov VV; Zhang G; Shao T; Zhang X; Yu Q; Rong J; Deng X
Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors.
Nat Commun Volume: 10 Page(s): 321
01/18/2019 Authors: Regan MC; Zhu Z; Yuan H; Myers SJ; Menaldino DS; Tahirovic YA; Liotta DC; Traynelis SF; Furukawa H
Distinct roles of GRIN2A and GRIN2B variants in neurological conditions.
F1000Res Volume: 8
01/01/2019 Authors: Myers SJ; Yuan H; Kang J-Q; Tan FCK; Traynelis SF; Low C-M
The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening.
Proteins Volume: 86 Page(s): 1265 - 1276
12/01/2018 Authors: Wells G; Yuan H; McDaniel MJ; Kusumoto H; Snyder JP; Liotta DC; Traynelis SF
Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells.
Neuron Volume: 99 Page(s): 315 - 328.e5
07/25/2018 Authors: Bhattacharya S; Khatri A; Swanger SA; DiRaddo JO; Yi F; Hansen KB; Yuan H; Traynelis SF
A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder.
Mov Disord Volume: 33 Page(s): 992 - 999
07/01/2018 Authors: Fernndez-Marmiesse A; Kusumoto H; Rekarte S; Roca I; Zhang J; Myers SJ; Traynelis SF; Couce ML; Gutierrez-Solana L; Yuan H
De Novo Mutations and Rare Variants Occurring in NMDA Receptors.
Curr Opin Physiol Volume: 2 Page(s): 27 - 35
04/01/2018 Authors: XiangWei W; Jiang Y; Yuan H
De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.
Brain Volume: 141 Page(s): 698 - 712
03/01/2018 Authors: Fry AE; Fawcett KA; Zelnik N; Yuan H; Thompson BAN; Shemer-Meiri L; Cushion TD; Mugalaasi H; Sims D; Stoodley N
GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects.
J Med Genet Volume: 54 Page(s): 460 - 470
07/01/2017 Authors: Platzer K; Yuan H; Schtz H; Winschel A; Chen W; Hu C; Kusumoto H; Heyne HO; Helbig KL; Tang S
GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function.
J Hum Genet Volume: 62 Page(s): 589 - 597
06/01/2017 Authors: Chen W; Shieh C; Swanger SA; Tankovic A; Au M; McGuire M; Tagliati M; Graham JM; Madan-Khetarpal S; Traynelis SF
A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density.
J Neurosci Volume: 37 Page(s): 4093 - 4102
04/12/2017 Authors: Liu S; Zhou L; Yuan H; Vieira M; Sanz-Clemente A; Badger JD; Lu W; Traynelis SF; Roche KW
Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy.
Mol Pharmacol Volume: 91 Page(s): 317 - 330
04/01/2017 Authors: Chen W; Tankovic A; Burger PB; Kusumoto H; Traynelis SF; Yuan H
Corrigendum to "Human GRIN2B variants in neurodevelopmental disorders" [J Pharmacol Sci 132 (2) 115-121].
J Pharmacol Sci Volume: 133 Page(s): 280
04/01/2017 Authors: Hu C; Chen W; Myers SJ; Yuan H; Traynelis SF
Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.
PLoS Genet Volume: 13 Page(s): e1006536
01/01/2017 Authors: Ogden KK; Chen W; Swanger SA; McDaniel MJ; Fan LZ; Hu C; Tankovic A; Kusumoto H; Kosobucki GJ; Schulien AJ
A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia.
PLoS One Volume: 12 Page(s): e0170818
01/01/2017 Authors: Gao K; Tankovic A; Zhang Y; Kusumoto H; Zhang J; Chen W; XiangWei W; Shaulsky GH; Hu C; Traynelis SF
Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains.
Am J Hum Genet Volume: 99 Page(s): 1261 - 1280
12/01/2016 Authors: Swanger SA; Chen W; Wells G; Burger PB; Tankovic A; Bhattacharya S; Strong KL; Hu C; Kusumoto H; Zhang J
NOVEL PHENOTYPIC- AND FUNCTIONAL ASPECTS OF HETEROZYGOUS DE NOVO MUTATIONS IN GRIN2B
Volume: 57 Page(s): 120 - 121
12/01/2016 Authors: Platzer K; Yuan H; Traynelis S; Lemke J
GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.
Am J Hum Genet Volume: 99 Page(s): 802 - 816
10/06/2016 Authors: Li D; Yuan H; Ortiz-Gonzalez XR; Marsh ED; Tian L; McCormick EM; Kosobucki GJ; Chen W; Schulien AJ; Chiavacci R
Human GRIN2B variants in neurodevelopmental disorders.
J Pharmacol Sci Volume: 132 Page(s): 115 - 121
10/01/2016 Authors: Hu C; Chen W; Myers SJ; Yuan H; Traynelis SF
A novel class of negative allosteric modulators of NMDA receptor function.
Bioorg Med Chem Lett Volume: 25 Page(s): 5583 - 5588
12/01/2015 Authors: Katzman BM; Perszyk RE; Yuan H; Tahirovic YA; Sotimehin AE; Traynelis SF; Liotta DC
Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.
Mol Pharmacol Volume: 88 Page(s): 203 - 217
07/01/2015 Authors: Yuan H; Low C-M; Moody OA; Jenkins A; Traynelis SF
GRIN1 Mutations in Early-Onset Epileptic Encephalopathy.
Pediatr Neurol Briefs Volume: 29 Page(s): 44
06/01/2015 Authors: Chen W; Yuan H
Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects.
Neuron Volume: 85 Page(s): 1305 - 1318
03/18/2015 Authors: Yuan H; Myers SJ; Wells G; Nicholson KL; Swanger SA; Lyuboslavsky P; Tahirovic YA; Menaldino DS; Ganesh T; Wilson LJ
Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.
Mol Genet Metab Volume: 113 Page(s): 161 - 170
11/01/2014 Authors: Adams DR; Yuan H; Holyoak T; Arajs KH; Hakimi P; Markello TC; Wolfe LA; Vilboux T; Burton BK; Fajardo KF
Glutamate Receptor Ion Channels: Structure, Regulation, and Function (vol 62, pg 405, 2010)
PHARMACOLOGICAL REVIEWS Volume: 66 Page(s): 1141 - 1141
10/01/2014 Authors: Traynelis SF; Wollmuth LP; McBain CJ; Menniti FS; Vance KM; Ogden KK; Hansen KB; Yuan H; Myers SJ; Dingledine R
Functional Changes of a De Novo GRIN2B Missense Mutation in a Patient with Developmental Delay
Volume: 76 Page(s): S74 - S74
10/01/2014 Authors: Yuan H; Swanger SA; Wells G; Hansen KB; Adams DR; Boerkoel CF; Toro C; Gahl WA; Synder JP; Traynelis SF
Two NMDA Receptor Mutations in Transmembrane Domain M3 Related to Early-Onset Seizures
Volume: 76 Page(s): S32 - S32
10/01/2014 Authors: Traynelis SF; Falk MJ; Yudkoff M; Li D; Tian L; Marsh ED; Ortiz-Gonzalez X; McCormick E; Lynch D; Hakonarson H
Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors.
Neuron Volume: 81 Page(s): 1084 - 1096
03/05/2014 Authors: Hansen KB; Ogden KK; Yuan H; Traynelis SF
GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine.
Ann Clin Transl Neurol Volume: 1 Page(s): 190 - 198
03/01/2014 Authors: Pierson TM; Yuan H; Marsh ED; Fuentes-Fajardo K; Adams DR; Markello T; Golas G; Simeonov DR; Holloman C; Tankovic A
Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy.
Nat Commun Volume: 5 Page(s): 3251
01/01/2014 Authors: Yuan H; Hansen KB; Zhang J; Pierson TM; Markello TC; Fajardo KVF; Holloman CM; Golas G; Adams DR; Boerkoel CF
Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators.
Mol Pharmacol Volume: 82 Page(s): 344 - 359
08/01/2012 Authors: Burger PB; Yuan H; Karakas E; Geballe M; Furukawa H; Liotta DC; Snyder JP; Traynelis SF
Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators.
Mol Pharmacol Volume: 80 Page(s): 782 - 795
11/01/2011 Authors: Acker TM; Yuan H; Hansen KB; Vance KM; Ogden KK; Jensen HS; Burger PB; Mullasseril P; Snyder JP; Liotta DC
Synthesis and SAR of a novel class of tetrahydroisoquinoline-based potentiators of NR2C/D containing NMDA receptors
Volume: 241
03/27/2011 Authors: Santangelo RM; Vance KM; Ogden KK; Yuan H; Hansen KB; Mullasseril P; Kurtkaya NL; Orr AG; Le P; Vellano KM
A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.
Nat Commun Volume: 1 Page(s): 90
10/05/2010 Authors: Mullasseril P; Hansen KB; Vance KM; Ogden KK; Yuan H; Kurtkaya NL; Santangelo R; Orr AG; Le P; Vellano KM
Glutamate receptor ion channels: structure, regulation, and function.
Pharmacol Rev Volume: 62 Page(s): 405 - 496
09/01/2010 Authors: Traynelis SF; Wollmuth LP; McBain CJ; Menniti FS; Vance KM; Ogden KK; Hansen KB; Yuan H; Myers SJ; Dingledine R
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
J Pharmacol Exp Ther Volume: 333 Page(s): 650 - 662
06/01/2010 Authors: Hansen KB; Mullasseril P; Dawit S; Kurtkaya NL; Yuan H; Vance KM; Orr AG; Kvist T; Ogden KK; Le P
The expression of the dopamine receptors in neurons and astrocytes of the substantia nigra pars reticulata by single-cell real time RT-PCR
NEUROSCIENCE RESEARCH Volume: 68 Page(s): E126 - E126
01/01/2010 Authors: Nagatomo K; Suga S; Shibasaki K; Watanabe N; Kodama S; Yuan H; Inagaki N; Yamamoto Y; Tominaga M; Yamada K
Dopamine receptor expression in substantia nigra pars reticulata -single-cell RT-PCR analysis-
JOURNAL OF PHYSIOLOGICAL SCIENCES Volume: 60 Page(s): S131 - S131
01/01/2010 Authors: Nagatomo K; Suga S; Shibasaki K; Watanabe N; Yuan H; Inagaki N; Yamamoto Y; Tominaga M; Yamada K
Dopamine-triggered gliotransmitter release in midbrain substantia nigra
JOURNAL OF PHYSIOLOGICAL SCIENCES Volume: 60 Page(s): S44 - S44
01/01/2010 Authors: Yamada K; Shibasaki K; Suga S; Watanabe N; Yuan H; Inagaki N; Yamamoto Y; Tominaga M; Nagatomo K
Control of NMDA receptor function by the NR2 subunit amino-terminal domain.
J Neurosci Volume: 29 Page(s): 12045 - 12058
09/30/2009 Authors: Yuan H; Hansen KB; Vance KM; Ogden KK; Traynelis SF
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.
Bioorg Med Chem Volume: 17 Page(s): 6463 - 6480
09/01/2009 Authors: Mosley CA; Myers SJ; Murray EE; Santangelo R; Tahirovic YA; Kurtkaya N; Mullasseril P; Yuan H; Lyuboslavsky P; Le P
The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors.
J Biol Chem Volume: 284 Page(s): 12862 - 12873
05/08/2009 Authors: Yuan H; Vance KM; Junge CE; Geballe MT; Snyder JP; Hepler JR; Yepes M; Low C-M; Traynelis SF
Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.
J Med Chem Volume: 51 Page(s): 5506 - 5521
09/25/2008 Authors: Tahirovic YA; Geballe M; Gruszecka-Kowalik E; Myers SJ; Lyuboslavsky P; Le P; French A; Irier H; Choi W-B; Easterling K
Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1.
J Biol Chem Volume: 283 Page(s): 20600 - 20611
07/18/2008 Authors: Mannaioni G; Orr AG; Hamill CE; Yuan H; Pedone KH; McCoy KL; Berlinguer Palmini R; Junge CE; Lee CJ; Yepes M
Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors.
Mol Pharmacol Volume: 72 Page(s): 907 - 920
10/01/2007 Authors: Erreger K; Geballe MT; Kristensen A; Chen PE; Hansen KB; Lee CJ; Yuan H; Le P; Lyuboslavsky PN; Micale N
Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1.
Mol Pharmacol Volume: 72 Page(s): 653 - 664
09/01/2007 Authors: Hamill CE; Caudle WM; Richardson JR; Yuan H; Pennell KD; Greene JG; Miller GW; Traynelis SF
Astrocytic control of synaptic NMDA receptors.
J Physiol Volume: 581 Page(s): 1057 - 1081
06/15/2007 Authors: Lee CJ; Mannaioni G; Yuan H; Woo DH; Gingrich MB; Traynelis SF
Structural aspects of AMPA receptor activation, desensitization and deactivation.
Curr Opin Neurobiol Volume: 17 Page(s): 281 - 288
06/01/2007 Authors: Hansen KB; Yuan H; Traynelis SF
Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block.
J Physiol Volume: 581 Page(s): 107 - 128
05/15/2007 Authors: Dravid SM; Erreger K; Yuan H; Nicholson K; Le P; Lyuboslavsky P; Almonte A; Murray E; Mosely C; Barber J
Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3.
J Biol Chem Volume: 280 Page(s): 29708 - 29716
08/19/2005 Authors: Yuan H; Erreger K; Dravid SM; Traynelis SF
Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling.
Mol Pharmacol Volume: 67 Page(s): 1470 - 1484
05/01/2005 Authors: Chen PE; Geballe MT; Stansfeld PJ; Johnston AR; Yuan H; Jacob AL; Snyder JP; Traynelis SF; Wyllie DJA
Glucose sensitivity in mouse substantia nigra pars reticulata neurons in vitro.
Neurosci Lett Volume: 355 Page(s): 173 - 176
01/30/2004 Authors: Yuan H; Yamada K; Inagaki N
Multiminute oscillations in mouse substantia nigra pars reticulata neurons in vitro.
Neurosci Lett Volume: 355 Page(s): 136 - 140
01/23/2004 Authors: Yuan H; Yamada K; Inagaki N
Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure.
Science Volume: 292 Page(s): 1543 - 1546
05/25/2001 Authors: Yamada K; Ji JJ; Yuan H; Miki T; Sato S; Horimoto N; Shimizu T; Seino S; Inagaki N

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