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Profile

Hua Yang MD/PhD

  • Department of Ophthalmology
    Associate
  • (404) 778-4723
  • hyang3@emory.edu
Head shot of Hua Yang

Overview

Uveal melanoma is the most common malignant ocular tumor in adults. Metastasis results in the high mortality rate after recovery or removal of the primary tumor. Dr. Yangs research interests are the control of metastatic melanoma from the eye to the liver with anti-angiogenesis and immune modulation therapies and understanding of the mechanisms of metastatic disease and exploration of targeted therapy based on biomarkers for primary and metastatic uveal melanoma.

Dr. Yang's previous research positions include: associate professor, Department of Ophthalmology, First Peoples Hospital of Shanghai and associate director in the Eye Institute of Shanghai, 1996-2004.

Academic Appointment

Education

Degrees

  • PhD from Hunan Medical University
  • MD from Hunan Medical University

Research

Publications

  • Early Detection and Staging of Lung Fibrosis Enabled by Collagen-Targeted MRI Protein Contrast Agent.
    Chem Biomed Imaging Volume: 1 Page(s): 268 - 285
    06/26/2023 Authors: Ibhagui OY; Li D; Han H; Peng G; Meister ML; Gui Z; Qiao J; Salarian M; Dong B; Yuan Y
  • Non-invasive detection and complementary diagnosis of liver metastases via chemokine receptor 4 imaging.
    Cancer Gene Ther Volume: 29 Page(s): 1827 - 1839
    12/01/2022 Authors: Yang H; Tan S; Qiao J; Xu Y; Gui Z; Meng Y; Dong B; Peng G; Ibhagui OY; Qian W
  • Targeting integrin v3 by a rationally designed protein for chronic liver disease treatment.
    Commun Biol Volume: 4 Page(s): 1087
    09/16/2021 Authors: Turaga RC; Satyanarayana G; Sharma M; Yang JJ; Wang S; Liu C; Li S; Yang H; Grossniklaus H; Farris AB
  • Role of Yes-associated Protein-1 in Gastrointestinal Cancers and Hepatocellular Carcinoma.
    Explor Res Hypothesis Med Volume: 6 Page(s): 110 - 117
    09/01/2021 Authors: Qian X; Zhang W; Yang H; Zhang L; Kang N; Lai J
  • Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth.
    Oncogene Volume: 40 Page(s): 5182 - 5191
    08/01/2021 Authors: Kaluz S; Zhang Q; Kuranaga Y; Yang H; Osuka S; Bhattacharya D; Devi NS; Mun J; Wang W; Zhang R
  • In Vivo Evaluation of a Miniaturized Fluorescence Molecular Tomography (FMT) Endoscope for Breast Cancer Detection Using Targeted Nanoprobes.
    Int J Mol Sci Volume: 21
    12/09/2020 Authors: Yang H; Qian W; Yang L; Xie H; Jiang H
  • Chemokine receptor 4 targeted protein MRI contrast agent for early detection of liver metastases.
    Sci Adv Volume: 6 Page(s): eaav7504
    02/01/2020 Authors: Tan S; Yang H; Xue S; Qiao J; Salarian M; Hekmatyar K; Meng Y; Mukkavilli R; Pu F; Odubade OY
  • Natural killer cells and pigment epithelial-derived factor control the infiltrative and nodular growth of hepatic metastases in an Orthotopic murine model of ocular melanoma.
    BMC Cancer Volume: 19 Page(s): 484
    05/22/2019 Authors: Jones NM; Yang H; Zhang Q; Morales-Tirado VM; Grossniklaus HE
  • Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma.
    Clin Cancer Res Volume: 25 Page(s): 2206 - 2218
    04/01/2019 Authors: Dong L; You S; Zhang Q; Osuka S; Devi NS; Kaluz S; Ferguson JH; Yang H; Chen G; Wang B
  • Rational design of a protein that binds integrin v3 outside the ligand binding site.
    Nat Commun Volume: 7 Page(s): 11675
    05/31/2016 Authors: Turaga RC; Yin L; Yang JJ; Lee H; Ivanov I; Yan C; Yang H; Grossniklaus HE; Wang S; Ma C
  • The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism.
    Oncotarget Volume: 7 Page(s): 2936 - 2950
    01/19/2016 Authors: Yang H; Brackett CM; Morales-Tirado VM; Li Z; Zhang Q; Wilson MW; Benjamin C; Harris W; Waller EK; Gudkov AV
  • GRPR-targeted Protein Contrast Agents for Molecular Imaging of Receptor Expression in Cancers by MRI.
    Sci Rep Volume: 5 Page(s): 16214
    11/18/2015 Authors: Pu F; Qiao J; Xue S; Yang H; Patel A; Wei L; Hekmatyar K; Salarian M; Grossniklaus HE; Liu Z-R
  • Effect of Anti-angiogenic Agents Targeting Integrins alpha(v)beta(3) on human uveal melanoma and vascular endothelia
    Volume: 56
    06/01/2015 Authors: Yang H; Grossniklaus HE; Harris W; Zhang Q; Waller EK; Chakra R; Liu Z-R
  • Uveal Melanoma Metastasis Models.
    Ocul Oncol Pathol Volume: 1 Page(s): 151 - 160
    04/01/2015 Authors: Yang H; Cao J; Grossniklaus HE
  • Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma.
    Clin Exp Metastasis Volume: 30 Page(s): 969 - 976
    12/01/2013 Authors: Lattier JM; Yang H; Crawford S; Grossniklaus HE
  • In vivo high-frequency contrast-enhanced ultrasonography of choroidal melanoma in rabbits: imaging features and histopathologic correlations.
    Br J Ophthalmol Volume: 97 Page(s): 929 - 933
    07/01/2013 Authors: Kang SJ; Zhang Q; Patel SR; Berezovsky D; Yang H; Wang Y; Grossniklaus HE
  • Development of a unique small molecule modulator of CXCR4.
    PLoS One Volume: 7 Page(s): e34038
    01/01/2012 Authors: Liang Z; Zhan W; Zhu A; Yoon Y; Lin S; Sasaki M; Klapproth J-MA; Yang H; Grossniklaus HE; Xu J
  • Author response: incorrect citation.
    Invest Ophthalmol Vis Sci Volume: 52 Page(s): 4368
    06/22/2011 Authors: Yang H; Grossniklaus HE
  • In vivo high-frequency, contrast-enhanced ultrasonography of uveal melanoma in mice: imaging features and histopathologic correlations.
    Invest Ophthalmol Vis Sci Volume: 52 Page(s): 2662 - 2668
    04/01/2011 Authors: Zhang Q; Yang H; Kang SJ; Wang Y; Wang GD; Coulthard T; Grossniklaus HE
  • HER2 targeted molecular MR imaging using a de novo designed protein contrast agent.
    PLoS One Volume: 6 Page(s): e18103
    03/24/2011 Authors: Qiao J; Li S; Wei L; Jiang J; Long R; Mao H; Wei L; Wang L; Yang H; Grossniklaus HE
  • Serum vascular endothelial growth factor (VEGF) levels correlate with number and location of micrometastases in a murine model of uveal melanoma.
    Br J Ophthalmol Volume: 95 Page(s): 112 - 117
    01/01/2011 Authors: Crosby MB; Yang H; Gao W; Zhang L; Grossniklaus HE
  • Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity.
    J Med Chem Volume: 53 Page(s): 8556 - 8568
    12/23/2010 Authors: Zhu A; Zhan W; Liang Z; Yoon Y; Yang H; Grossniklaus HE; Xu J; Rojas M; Lockwood M; Snyder JP
  • Bevacizumab suppression of establishment of micrometastases in experimental ocular melanoma.
    Invest Ophthalmol Vis Sci Volume: 51 Page(s): 2835 - 2842
    06/01/2010 Authors: Yang H; Jager MJ; Grossniklaus HE
  • Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis.
    Invest Ophthalmol Vis Sci Volume: 51 Page(s): 28 - 34
    01/01/2010 Authors: Yang H; Grossniklaus HE
  • Modulation of choroidal neovascularization by subretinal injection of retinal pigment epithelium and polystyrene microbeads.
    Mol Vis Volume: 15 Page(s): 146 - 161
    01/01/2009 Authors: Schmack I; Berglin L; Nie X; Wen J; Kang SJ; Marcus AI; Yang H; Lynn MJ; Kapp JA; Grossniklaus HE
  • In-vivo xenograft murine human uveal melanoma model develops hepatic micrometastases.
    Melanoma Res Volume: 18 Page(s): 95 - 103
    04/01/2008 Authors: Yang H; Fang G; Huang X; Yu J; Hsieh C-L; Grossniklaus HE
  • Combined immunologic and anti-angiogenic therapy reduces hepatic micrometastases in a murine ocular melanoma model.
    Curr Eye Res Volume: 31 Page(s): 557 - 562
    06/01/2006 Authors: Yang H; Grossniklaus HE
  • Angiostatin decreases cell migration and vascular endothelium growth factor (VEGF) to pigment epithelium derived factor (PEDF) RNA ratio in vitro and in a murine ocular melanoma model.
    Mol Vis Volume: 12 Page(s): 511 - 517
    05/22/2006 Authors: Yang H; Xu Z; Iuvone PM; Grossniklaus HE
  • Low dose adjuvant angiostatin decreases hepatic micrometastasis in murine ocular melanoma model.
    Mol Vis Volume: 10 Page(s): 987 - 995
    12/23/2004 Authors: Yang H; Akor C; Dithmar S; Grossniklaus HE
  • Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells.
    Invest Ophthalmol Vis Sci Volume: 45 Page(s): 4183 - 4189
    11/01/2004 Authors: Armstrong JS; Whiteman M; Yang H; Jones DP; Sternberg P
  • Interferon alpha 2b decreases hepatic micrometastasis in a murine model of ocular melanoma by activation of intrinsic hepatic natural killer cells.
    Invest Ophthalmol Vis Sci Volume: 45 Page(s): 2056 - 2064
    07/01/2004 Authors: Yang H; Dithmar S; Grossniklaus HE
  • Murine model of choroidal neovascularization with subretinal beads and heterologous retinal pigment epithelial (RPE) cells
    Volume: 45 Page(s): U732 - U732
    04/01/2004 Authors: Nie X; Berglin CL; Wen J; Hernault NL; Yang H; Kapp J; Grossniklaus HE
  • A new RPE flatmount technique for comparative morphometric analysis using Alizarin red staining, confocal and electron microscopy in different species
    Volume: 45 Page(s): U191 - U191
    04/01/2004 Authors: Berglin LC; Holley G; Yanni S; Grossniklaus HE; Hernault NL; Nie X; Yang H
  • Vascular endothelial growth factor (VEGF) pigment epithelium derived factor (PEDF) balance in uveal melanoma
    Volume: 45 Page(s): U608 - U608
    04/01/2004 Authors: Yang H; Nie X; Dithmar S; Berglin CL; Grossniklaus HE
  • Interferon alpha-2b decreases hepatic micrometastasis from ocular melanoma by activation of NK cells
    Volume: 44 Page(s): U367 - U367
    05/01/2003 Authors: Grossniklaus HE; Yang H; Dithmar S
  • Low-dose angiostatin decreases hepatic micrometastasis in murine ocular melanoma model
    Volume: 44 Page(s): U255 - U255
    05/01/2003 Authors: Yang H; Dithmar S; Grossniklaus HE
  • Analysis of angiostatin activity and angiostatin treatment in a murine model for metastatic ocular melanoma
    Volume: 43 Page(s): U245 - U245
    05/01/2002 Authors: Dithmar S; Yang H; Freeman J; Grossniklaus HE
  • Angiostatin expression in human and marine melanoma cell lines
    Volume: 43 Page(s): U245 - U245
    05/01/2002 Authors: Yang H; Liu P; Freeman J; Grossniklaus HE
  • Effect of angiostatin on the in vitro melanoma invasion
    Volume: 43 Page(s): U245 - U245
    05/01/2002 Authors: Akor CM; Campbell R; Yang H; Grossniklaus HE
  • [A Chinese family with autosomal dominant retinitis pigmentosa and a pro347Leu rhodopsin gene mutation].
    Chin Med J (Engl) Volume: 113 Page(s): 574 - 576
    06/01/2000 Authors: Yang H; Luo C; Zhou J; Yan M
  • Newcastle Disease Virus oncolysate treatment of metastatic ocular melanoma in a murine model.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Volume: 41 Page(s): S385 - S385
    03/15/2000 Authors: Adams AW; Dithmar S; Dodson DD; Yang H; Bonaccorsi P; Ansel JC; Grossniklaus HE; Armstrong CA
  • [The study of RDS gene mutation and clinical phenotype in a family with primary retinitis pigmentosa].
    Zhonghua Yan Ke Za Zhi Volume: 36 Page(s): 52 - 7
    01/01/2000 Authors: Yang H; Luo C; Zhou J; Yan M; Chen D; Huang Q
  • [The features of color pattern electroretinogram in early primary open-angle glaucoma].
    Zhonghua Yan Ke Za Zhi Volume: 32 Page(s): 272 - 276
    07/01/1996 Authors: Yang H; Jiang Y; Wu Z
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