Hua Yang MD/PhD
Overview
Uveal melanoma is the most common malignant ocular tumor in adults. Metastasis results in the high mortality rate after recovery or removal of the primary tumor. Dr. Yangs research interests are the control of metastatic melanoma from the eye to the liver with anti-angiogenesis and immune modulation therapies and understanding of the mechanisms of metastatic disease and exploration of targeted therapy based on biomarkers for primary and metastatic uveal melanoma.
Dr. Yang's previous research positions include: associate professor, Department of Ophthalmology, First Peoples Hospital of Shanghai and associate director in the Eye Institute of Shanghai, 1996-2004.
Academic Appointment
Education
Degrees
- PhD from Hunan Medical University
- MD from Hunan Medical University
Research
Publications
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Early Detection and Staging of Lung Fibrosis Enabled by Collagen-Targeted MRI Protein Contrast Agent.
Chem Biomed Imaging Volume: 1 Page(s): 268 - 285
06/26/2023 Authors: Ibhagui OY; Li D; Han H; Peng G; Meister ML; Gui Z; Qiao J; Salarian M; Dong B; Yuan Y -
Non-invasive detection and complementary diagnosis of liver metastases via chemokine receptor 4 imaging.
Cancer Gene Ther Volume: 29 Page(s): 1827 - 1839
12/01/2022 Authors: Yang H; Tan S; Qiao J; Xu Y; Gui Z; Meng Y; Dong B; Peng G; Ibhagui OY; Qian W -
Targeting integrin v3 by a rationally designed protein for chronic liver disease treatment.
Commun Biol Volume: 4 Page(s): 1087
09/16/2021 Authors: Turaga RC; Satyanarayana G; Sharma M; Yang JJ; Wang S; Liu C; Li S; Yang H; Grossniklaus H; Farris AB -
Role of Yes-associated Protein-1 in Gastrointestinal Cancers and Hepatocellular Carcinoma.
Explor Res Hypothesis Med Volume: 6 Page(s): 110 - 117
09/01/2021 Authors: Qian X; Zhang W; Yang H; Zhang L; Kang N; Lai J -
Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth.
Oncogene Volume: 40 Page(s): 5182 - 5191
08/01/2021 Authors: Kaluz S; Zhang Q; Kuranaga Y; Yang H; Osuka S; Bhattacharya D; Devi NS; Mun J; Wang W; Zhang R -
In Vivo Evaluation of a Miniaturized Fluorescence Molecular Tomography (FMT) Endoscope for Breast Cancer Detection Using Targeted Nanoprobes.
Int J Mol Sci Volume: 21
12/09/2020 Authors: Yang H; Qian W; Yang L; Xie H; Jiang H -
Chemokine receptor 4 targeted protein MRI contrast agent for early detection of liver metastases.
Sci Adv Volume: 6 Page(s): eaav7504
02/01/2020 Authors: Tan S; Yang H; Xue S; Qiao J; Salarian M; Hekmatyar K; Meng Y; Mukkavilli R; Pu F; Odubade OY -
Natural killer cells and pigment epithelial-derived factor control the infiltrative and nodular growth of hepatic metastases in an Orthotopic murine model of ocular melanoma.
BMC Cancer Volume: 19 Page(s): 484
05/22/2019 Authors: Jones NM; Yang H; Zhang Q; Morales-Tirado VM; Grossniklaus HE -
Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma.
Clin Cancer Res Volume: 25 Page(s): 2206 - 2218
04/01/2019 Authors: Dong L; You S; Zhang Q; Osuka S; Devi NS; Kaluz S; Ferguson JH; Yang H; Chen G; Wang B -
Rational design of a protein that binds integrin v3 outside the ligand binding site.
Nat Commun Volume: 7 Page(s): 11675
05/31/2016 Authors: Turaga RC; Yin L; Yang JJ; Lee H; Ivanov I; Yan C; Yang H; Grossniklaus HE; Wang S; Ma C