Hyojung Choo

Department of Cell Biology
Assistant Professor

hyojung.choo@emory.edu

Emory University, School of Medicine
Cell Biology
615 Michael street Rm 542

Academic Appointment

Assistant Professor, Emory University

Education

Degrees

PhD from Korea University
BS from Korea University

Research

Focus

craniofacial muscle stem cells
Stem cell regulation of craniofacial muscle dysfunctions; Development of preclinical and clinical devices for dysphagia (swallowing difficulty); Drug development for muscular dystrophy (LGMD and DMD) and hindlimb ischemia.

Publications

Automatic Clinical Assessment of Swallowing Behavior and Diagnosis of Silent Aspiration Using Wireless Multimodal Wearable Electronics.
Adv Sci (Weinh) Volume: 11 Page(s): e2404211
09/01/2024 Authors: Shin B; Lee SH; Kwon K; Lee YJ; Crispe N; Ahn S-Y; Shelly S; Sundholm N; Tkaczuk A; Yeo M-K
All-in-one wearable drug efficacy assessment systems for bulbar muscle function using amyotrophic lateral sclerosis animal models.
Nat Commun Volume: 15 Page(s): 6803
08/09/2024 Authors: Shin B; Kwon Y; Mittaz M; Kim H; Xu X; Kim E; Lee YJ; Lee J; Yeo W-H; Choo HJ
Sex differences in the involvement of skeletal and cardiac muscles in myopathic Ano5-/- mice.
Am J Physiol Cell Physiol Volume: 322 Page(s): C283 - C295
02/01/2022 Authors: Foltz S; Wu F; Ghazal N; Kwong JQ; Hartzell HC; Choo HJ
Pharyngeal pathology in a mouse model of oculopharyngeal muscular dystrophy is associated with impaired basal autophagy in myoblasts.
Front Cell Dev Biol Volume: 10 Page(s): 986930
01/01/2022 Authors: Zhang Y; Zeuthen C; Zhu C; Wu F; Mezzell AT; Whitlow TJ; Choo HJ; Vest KE
Fibroadipogenic Progenitors Regulate the Basal Proliferation of Satellite Cells and Homeostasis of Pharyngeal Muscles via HGF Secretion.
Front Cell Dev Biol Volume: 10 Page(s): 875209
01/01/2022 Authors: Kim E; Wu F; Lim D; Zeuthen C; Zhang Y; Allen J; Muraine L; Trollet C; Vest KE; Choo HJ
Real-Time Functional Assay of Volumetric Muscle Loss Injured Mouse Masseter Muscles via Nanomembrane Electronics.
Adv Sci (Weinh) Volume: 8 Page(s): e2101037
09/01/2021 Authors: Kim H; Kwon Y-T; Zhu C; Wu F; Kwon S; Yeo W-H; Choo HJ
ANO5 ensures trafficking of annexins in wounded myofibers.
J Cell Biol Volume: 220
03/01/2021 Authors: Foltz SJ; Cui YY; Choo HJ; Hartzell HC
Generation of craniofacial myogenic progenitor cells from human induced pluripotent stem cells for skeletal muscle tissue regeneration.
Biomaterials Volume: 248 Page(s): 119995
07/01/2020 Authors: Kim E; Wu F; Wu X; Choo HJ
From worms to fish to mice.
Elife Volume: 9
05/06/2020 Authors: Benian GM; Choo HJ
Myosoft: An automated muscle histology analysis tool using machine learning algorithm utilizing FIJI/ImageJ software.
PLoS One Volume: 15 Page(s): e0229041
01/01/2020 Authors: Encarnacion-Rivera L; Foltz S; Hartzell HC; Choo H
The mitochondrial calcium uniporter regulates procoagulant platelet formation.
J Thromb Haemost Volume: 16 Page(s): 2315 - 2321
11/01/2018 Authors: Kholmukhamedov A; Janecke R; Choo H-J; Jobe SM
A tale of two niches: differential functions for VCAM-1 in satellite cells under basal and injured conditions.
Am J Physiol Cell Physiol Volume: 313 Page(s): C392 - C404
10/01/2017 Authors: Choo H-J; Canner JP; Vest KE; Thompson Z; Pavlath GK
Inner Mitochondrial Membrane Disruption Links Apoptotic and Agonist-Initiated Phosphatidylserine Externalization in Platelets.
Arterioscler Thromb Vasc Biol Volume: 37 Page(s): 1503 - 1512
08/01/2017 Authors: Choo H-J; Kholmukhamedov A; Zhou C; Jobe S
Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import.
Stem Cells Volume: 34 Page(s): 2784 - 2797
11/01/2016 Authors: Choo H-J; Cutler A; Rother F; Bader M; Pavlath GK
Pharyngeal Satellite Cells Undergo Myogenesis Under Basal Conditions and Are Required for Pharyngeal Muscle Maintenance.
Stem Cells Volume: 33 Page(s): 3581 - 3595
12/01/2015 Authors: Randolph ME; Phillips BL; Choo H-J; Vest KE; Vera Y; Pavlath GK
Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation.
J Biol Chem Volume: 289 Page(s): 20012 - 20025
07/18/2014 Authors: Hong J; Kim B-W; Choo H-J; Park J-J; Yi J-S; Yu D-M; Lee H; Yoon G-S; Lee J-S; Ko Y-G
Does platelet activation mediate pathogenesis of malaria infection?
Volume: 11 Page(s): 106 - 106
07/01/2013 Authors: Jobe SM; Schenk M; Zhou C; Choo H; Gibbins JM; Lamb TJ
Aggregation of PS exposing platelets and activated (non-PS exposing) platelets
Volume: 11 Page(s): 639 - 640
07/01/2013 Authors: Choo H; Jobe S
Inner mitochondrial membrane disruption is closely associated with both Bax/Bak and cyclophilin D-mediated platelet phosphatidylserine exposure
Volume: 11 Page(s): 501 - 502
07/01/2013 Authors: Choo H; Jobe S
Mitochondrial calcium and reactive oxygen species regulate agonist-initiated platelet phosphatidylserine exposure.
Arterioscler Thromb Vasc Biol Volume: 32 Page(s): 2946 - 2955
12/01/2012 Authors: Choo H-J; Saafir TB; Mkumba L; Wagner MB; Jobe SM
Platelet functions require correct protein O-glycosylation
Volume: 22 Page(s): 1632 - 1632
11/01/2012 Authors: Wang Y; Jobe SM; Ding X; Choo H; Archer D; Mi R; Ju T; Cummings RD
Platelet biogenesis and functions require correct protein O-glycosylation.
Proc Natl Acad Sci U S A Volume: 109 Page(s): 16143 - 16148
10/02/2012 Authors: Wang Y; Jobe SM; Ding X; Choo H; Archer DR; Mi R; Ju T; Cummings RD
Regulation of Platelet Procoagulant Activity by Mitochondrial Calcium Influx
Volume: 118 Page(s): 957 - 957
11/18/2011 Authors: Choo H; Jobe SM
Lipid raft proteome reveals that oxidative phosphorylation system is associated with the plasma membrane.
Expert Rev Proteomics Volume: 7 Page(s): 849 - 866
12/01/2010 Authors: Kim B-W; Lee CS; Yi J-S; Lee J-H; Lee J-W; Choo H-J; Jung S-Y; Kim M-S; Lee S-W; Lee M-S
Changes In mitochondrial Permeability Initiate Platelet Phosphatidylserine Exposure In Response to Elevated - Cytoplasmic Calcium Levels
Volume: 116 Page(s): 842 - 842
11/19/2010 Authors: Choo H; Saafir T; Wagner M; Jobe S
TRIM72 negatively regulates myogenesis via targeting insulin receptor substrate-1.
Cell Death Differ Volume: 17 Page(s): 1254 - 1265
08/01/2010 Authors: Lee CS; Yi J-S; Jung S-Y; Kim B-W; Lee N-R; Choo H-J; Jang S-Y; Han J; Chi S-G; Park M
Mitochondrial oxidative phosphorylation system is recruited to detergent-resistant lipid rafts during myogenesis.
Proteomics Volume: 10 Page(s): 2498 - 2515
07/01/2010 Authors: Kim B-W; Lee J-W; Choo H-J; Lee CS; Jung S-Y; Yi J-S; Ham Y-M; Lee J-H; Hong J; Kang M-J
Ginsenoside Rh2 induces ligand-independent Fas activation via lipid raft disruption.
Biochem Biophys Res Commun Volume: 385 Page(s): 154 - 159
07/24/2009 Authors: Yi J-S; Choo H-J; Cho B-R; Kim H-M; Kim Y-N; Ham Y-M; Ko Y-G
Proteome analysis of adipocyte lipid rafts reveals that gC1qR plays essential roles in adipogenesis and insulin signal transduction.
Proteomics Volume: 9 Page(s): 2373 - 2382
05/01/2009 Authors: Kim K-B; Kim B-W; Choo H-J; Kwon Y-C; Ahn B-Y; Choi J-S; Lee J-S; Ko Y-G
PHB2 interacts with RNF2 and represses CP2c-stimulated transcription.
Mol Cell Biochem Volume: 319 Page(s): 69 - 77
12/01/2008 Authors: Lee S-J; Choi D; Rhim H; Choo H-J; Ko Y-G; Kim CG; Kang S
Two-photon fluorescent probes for biomembrane imaging: effect of chain length.
Chembiochem Volume: 9 Page(s): 2830 - 2838
11/24/2008 Authors: Kim HM; Kim BR; Choo H-J; Ko Y-G; Jeon S-J; Kim CH; Joo T; Cho BR
Secretion of adenylate kinase 1 is required for extracellular ATP synthesis in C2C12 myotubes.
Exp Mol Med Volume: 40 Page(s): 220 - 228
04/30/2008 Authors: Choo H-J; Kim B-W; Kwon O-B; Lee CS; Choi J-S; Ko Y-G
A two-photon fluorescent probe for lipid raft imaging: C-laurdan.
Chembiochem Volume: 8 Page(s): 553 - 559
03/26/2007 Authors: Kim HM; Choo H-J; Jung S-Y; Ko Y-G; Park W-H; Jeon S-J; Kim CH; Joo T; Cho BR
Mitochondria are impaired in the adipocytes of type 2 diabetic mice.
Diabetologia Volume: 49 Page(s): 784 - 791
04/01/2006 Authors: Choo H-J; Kim J-H; Kwon O-B; Lee CS; Mun JY; Han SS; Yoon Y-S; Yoon G; Choi K-M; Ko Y-G
Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary DNA microarray.
Nucl Med Commun Volume: 26 Page(s): 1155 - 1162
12/01/2005 Authors: Gol Choe J; Kim Y-R; Kim K-N; Choo H-J; Shin J-H; Lee Y-J; Chung J-K; Kim M-K
Two-dimensional electrophoretic analysis reveals that lipid rafts are intact at physiological temperature.
Proteomics Volume: 4 Page(s): 3527 - 3535
11/01/2004 Authors: Kim K-B; Kim S-I; Choo H-J; Kim J-H; Ko Y-G
Lipid raft proteome reveals ATP synthase complex in the cell surface.
Proteomics Volume: 4 Page(s): 3536 - 3548
11/01/2004 Authors: Bae T-J; Kim M-S; Kim J-W; Kim B-W; Choo H-J; Lee J-W; Kim K-B; Lee CS; Kim J-H; Chang SY
Extracellular ATP is generated by ATP synthase complex in adipocyte lipid rafts.
Exp Mol Med Volume: 36 Page(s): 476 - 485
10/31/2004 Authors: Kim B-W; Choo H-J; Lee J-W; Kim J-H; Ko Y-G
Genome-wide expression profiling of 8-chloroadenosine- and 8-chloro-cAMP-treated human neuroblastoma cells using radioactive human cDNA microarray.
Exp Mol Med Volume: 34 Page(s): 184 - 193
07/31/2002 Authors: Park GH; Choe J; Choo H-J; Park YG; Sohn J; Kim M-K

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Profile

Hyojung Choo

Academic Appointment

Education

Degrees

Research

Focus

craniofacial muscle stem cells

Publications