Gregory Melikian
Academic Appointment
- Professor, Emory University School of Medicine
Education
Degrees
- PhD from Institute of Electrochemistry
- M.S from Yerevan State University
- BS from Yerevan State University
Research
Focus
- My research is aimed at understanding the entry of enveloped viruses into cells with a primary focus on HIV-1 and other retroviruses. My goal is to delineate the molecular mechanisms by which diverse viruses fuse their envelope to a cell membrane and to identify cellular factors required for virus entry.
Publications
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Rolosense: Mechanical Detection of SARS-CoV-2 Using a DNA-Based Motor.
ACS Cent Sci Volume: 10 Page(s): 1332 - 1347
07/24/2024 Authors: Piranej S; Zhang L; Bazrafshan A; Marin M; Melikian GB; Salaita K -
Disruption of Transmembrane Phosphatidylserine Asymmetry by HIV-1 Incorporated SERINC5 Is Not Responsible for Virus Restriction.
Biomolecules Volume: 14
05/10/2024 Authors: Raghunath G; Abbott EH; Marin M; Wu H; Reyes Ballista JM; Brindley MA; Melikyan GB -
Bioorthogonal click labeling of an amber-free HIV-1 provirus for in-virus single molecule imaging.
Cell Chem Biol Volume: 31 Page(s): 487 - 501.e7
03/21/2024 Authors: Ao Y; Grover JR; Gifford L; Han Y; Zhong G; Katte R; Li W; Bhattacharjee R; Zhang B; Sauve S -
Influenza D virus utilizes both 9-O-acetylated N-acetylneuraminic and 9-O-acetylated N-glycolylneuraminic acids as functional entry receptors.
J Virol Volume: 98 Page(s): e0004224
03/19/2024 Authors: Uprety T; Yu J; Nogales A; Naveed A; Yu H; Chen X; Liu Y; Bowman AS; Martinez-Sobrido L; Parrish CR -
HIV-1 Capsid Uncoating Is a Multistep Process That Proceeds through Defect Formation Followed by Disassembly of the Capsid Lattice.
ACS Nano Volume: 18 Page(s): 2928 - 2947
01/30/2024 Authors: Gifford LB; Melikyan GB -
IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters.
Viruses Volume: 15
12/07/2023 Authors: Verma S; Chen Y-C; Marin M; Gillespie SE; Melikyan GB -
Label-free imaging of nuclear membrane for analysis of nuclear import of viral complexes.
J Virol Methods Volume: 322 Page(s): 114834
12/01/2023 Authors: Ten Eyck A; Chen Y-C; Gifford L; Torres-Rivera D; Dyer EL; Melikyan GB -
Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.
Nat Commun Volume: 14 Page(s): 5614
09/12/2023 Authors: Gres AT; Kirby KA; McFadden WM; Du H; Liu D; Xu C; Bryer AJ; Perilla JR; Shi J; Aiken C -
Human Immunodeficiency Virus 1 Preferentially Fuses with pH-Neutral Endocytic Vesicles in Cell Lines and Human Primary CD4+ T-Cells.
ACS Nano Volume: 17 Page(s): 17436 - 17450
09/12/2023 Authors: Sharma M; Marin M; Wu H; Prikryl D; Melikyan GB -
Fusogenic structural changes in arenavirus glycoproteins are associated with viroporin activity.
PLoS Pathog Volume: 19 Page(s): e1011217
07/01/2023 Authors: Zhang Y; York J; Brindley MA; Nunberg JH; Melikyan GB