Publications

• Sensitizing solid tumors to CAR-mediated cytotoxicity by lipid nanoparticle delivery of synthetic antigens.
  Volume: 6 Page(s): 1073 - 1087
  06/01/2025 Authors: Gamboa L; Zamat AH; Thiveaud CA; Lee HJ; Kulaksizoglu E; Zha Z; Campbell NS; Chan CS; Fbrega S; Oliver SA
• AND-gated protease-activated nanosensors for programmable detection of anti-tumour immunity.
  Nat Nanotechnol Volume: 20 Page(s): 441 - 450
  03/01/2025 Authors: Sivakumar A; Phuengkham H; Rajesh H; Mac QD; Rogers LC; Silva Trenkle AD; Bawage SS; Hincapie R; Li Z; Vainikos S
• A facile yeast-display approach for antibody mask discovery.
  Protein Eng Des Sel Volume: 38
  01/10/2025 Authors: Badarinath NM; Mondal B; Yellman CM; Holland KL; Lee HJ; Phuengkham H; Cazier AP; Son J; Smith JR; Cox JR
• Quantifying UV-induced photodamage for longitudinal live-cell imaging applications of deep-UV microscopy.
  Biomed Opt Express Volume: 16 Page(s): 208 - 221
  01/01/2025 Authors: Gorti V; McCubbins K; Houston D; Silva Trenkle AD; Holberton A; Serafini CE; Wood L; Kwong G; Robles FE
• Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy.
  Nat Commun Volume: 15 Page(s): 10444
  12/01/2024 Authors: Wu Y; Huang Z; Liu Y; He P; Wang Y; Yan L; Wang X; Gao S; Zhou X; Yoon CW
• Antigen-specific T cell immunotherapy by in vivo mRNA delivery.
  bioRxiv
  11/03/2024 Authors: Su F-Y; Siebart JC; Chan CS; Wang MY; Yao X; Trenkle AS; Sivakumar A; Su M; Harandi R; Shahrawat N
• In vivo gene delivery to immune cells.
  Curr Opin Biotechnol Volume: 88 Page(s): 103169
  08/01/2024 Authors: Siebart JC; Chan CS; Yao X; Su F-Y; Kwong GA
• Light-field flow cytometry for high-resolution, volumetric and multiparametric 3D single-cell analysis.
  Nat Commun Volume: 15 Page(s): 1975
  03/04/2024 Authors: Hua X; Han K; Mandracchia B; Radmand A; Liu W; Kim H; Yuan Z; Ehrlich SM; Li K; Zheng C
• Rescue of NLRC5 expression restores antigen processing machinery in head and neck cancer cells lacking functional STAT1 and p53.
  Cancer Immunol Immunother Volume: 73 Page(s): 10
  01/17/2024 Authors: Kinney BLC; Gunti S; Kansal V; Parrish CJ; Saba NF; Teng Y; Henry MK; Su F-Y; Kwong GA; Schmitt NC
• Portable light-sheet optofluidic microscopy for 3D fluorescence imaging flow cytometry.
  Lab Chip Volume: 23 Page(s): 624 - 630
  02/14/2023 Authors: Son J; Mandracchia B; Silva Trenkle AD; Kwong GA; Jia S
• Embracing enzyme promiscuity with activity-based compressed biosensing.
  Cell Rep Methods Volume: 3 Page(s): 100372
  01/23/2023 Authors: Holt BA; Lim HS; Sivakumar A; Phuengkham H; Su M; Tuttle M; Xu Y; Liakakos H; Qiu P; Kwong GA
• Urinary detection of early responses to checkpoint blockade and of resistance to it via protease-cleaved antibody-conjugated sensors.
  Nat Biomed Eng Volume: 6 Page(s): 310 - 324
  03/01/2022 Authors: Mac QD; Sivakumar A; Phuengkham H; Xu C; Bowen JR; Su F-Y; Stentz SZ; Sim H; Harris AM; Li TT
• In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles.
  Sci Adv Volume: 8 Page(s): eabm7950
  02/25/2022 Authors: Su F-Y; Zhao QH; Dahotre SN; Gamboa L; Bawage SS; Silva Trenkle AD; Zamat A; Phuengkham H; Ahmed R; Santangelo PJ
• Dimensionless parameter predicts bacterial prodrug success.
  Mol Syst Biol Volume: 18 Page(s): e10495
  01/01/2022 Authors: Holt BA; Tuttle M; Xu Y; Su M; Rise JJ; Wang X; Murthy N; Kwong GA
• Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control.
  Nat Biomed Eng Volume: 5 Page(s): 1348 - 1359
  11/01/2021 Authors: Miller IC; Zamat A; Sun L-K; Phuengkham H; Harris AM; Gamboa L; Yang J; Murad JP; Priceman SJ; Kwong GA
• Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors.
  Sci Transl Med Volume: 13 Page(s): eabe8939
  10/20/2021 Authors: Cazanave SC; Warren AD; Pacula M; Touti F; Zagorska A; Gural N; Huang EK; Sherman S; Cheema M; Ibarra S
• Synthetic biomarkers: a twenty-first century path to early cancer detection.
  Nat Rev Cancer Volume: 21 Page(s): 655 - 668
  10/01/2021 Authors: Kwong GA; Ghosh S; Gamboa L; Patriotis C; Srivastava S; Bhatia SN
• Interfacing Biomaterials with Synthetic T Cell Immunity.
  Adv Healthc Mater Volume: 10 Page(s): e2100157
  08/01/2021 Authors: Su F-Y; Mac QD; Sivakumar A; Kwong GA
• DNA Gold Nanoparticle Motors Demonstrate Processive Motion with Bursts of Speed Up to 50 nm Per Second.
  ACS Nano Volume: 15 Page(s): 8427 - 8438
  05/25/2021 Authors: Bazrafshan A; Kyriazi M-E; Holt BA; Deng W; Piranej S; Su H; Hu Y; El-Sagheer AH; Brown T; Kwong GA
• ACTIVITY SENSORS FOR NONINVASIVE MONITORING OF IMMUNE RESPONSE AND TUMOR RESISTANCE DURING IMMUNE CHECKPOINT BLOCKADE THERAPY
  Volume: 8 Page(s): A9 - A9
  11/01/2020 Authors: Mac Q; Bowen J; Phuengkham H; Sivakumar A; Xu C; Su F-Y; Stentz S; Sim H; Harris A; Li T
• SAFETY AND TOLERABILITY IN HEALTHY VOLUNTEERS OF THE GLYMPSE BIO TEST SYSTEM-NASH DIAGNOSTIC
  Volume: 72 Page(s): 941 - 942
  11/01/2020 Authors: Azeem R; Brimhall D; Pacula M; Weisman M; Miller V; Ibarra S; Cazanave S; Bhatia S; Kwong G; Winckler W
• HEPATIC PROTEASE GENE EXPRESSION ANALYSIS TO PREDICT ADVANCED FIBROSIS IN PATIENTS WITH NASH: A CROSS-VALIDATION STUDY
  Volume: 72 Page(s): 918A - 919A
  11/01/2020 Authors: Cazanave S; Pacula M; Huang EK; Kwong G; Luther J; Corey KE; Chung RT; Daly A; Govaere O; Anstee QM
• Protease circuits for processing biological information.
  Nat Commun Volume: 11 Page(s): 5021
  10/06/2020 Authors: Holt BA; Kwong GA
• Harnessing lipid signaling pathways to target specialized pro-angiogenic neutrophil subsets for regenerative immunotherapy.
  Sci Adv Volume: 6
  10/01/2020 Authors: Turner TC; Sok MCP; Hymel LA; Pittman FS; York WY; Mac QD; Vyshnya S; Lim HS; Kwong GA; Qiu P
• STAR particles for enhanced topical drug and vaccine delivery.
  Nat Med Volume: 26 Page(s): 341 - 347
  03/21/2025 Authors: Tadros AR; Romanyuk A; Miller IC; Santiago A; Noel RK; O'Farrell L; Kwong GA; Prausnitz MR
• Heat-Triggered Remote Control of CRISPR-dCas9 for Tunable Transcriptional Modulation.
  ACS Chem Biol Volume: 15 Page(s): 533 - 542
  02/21/2020 Authors: Gamboa L; Phung EV; Li H; Meyers JP; Hart AC; Miller IC; Kwong GA
• Macrophage Sensors for Early Cancer Detection.
  Clin Chem Volume: 66 Page(s): 268 - 270
  02/01/2020 Authors: Kwong GA
• Synthetic immunity by remote control.
  Theranostics Volume: 10 Page(s): 3652 - 3667
  01/01/2020 Authors: Gamboa L; Zamat AH; Kwong GA
• GLYMPSE LIVER TEST FOR NONINVASIVE MONITORING OF COMBINATION DRUG THERAPY IN A RAT MODEL OF NONALCOHOLIC STEATOHEPATITIS (NASH)
  Volume: 70 Page(s): 1028A - 1029A
  10/01/2019 Authors: Cazanave S; Pacula M; Zagorska A; Warren A; Sherman S; Huang EK; Walker K; Liu K; Lopez D; Newstrom D
• Deconvolving multiplexed protease signatures with substrate reduction and activity clustering.
  PLoS Comput Biol Volume: 15 Page(s): e1006909
  09/01/2019 Authors: Zhuang Q; Holt BA; Kwong GA; Qiu P
• Protease activity sensors for non-invasive monitoring of NASH
  Volume: 70 Page(s): E760 - E760
  04/01/2019 Authors: Cazanave S; Warren A; Huang E; Kwong G; Luther J; Corey K; Chung R; Bhatia S
• Non-invasive early detection of acute transplant rejection via nanosensors of granzymeB activity.
  Nat Biomed Eng Volume: 3 Page(s): 281 - 291
  04/01/2019 Authors: Mac QD; Mathews DV; Kahla JA; Stoffers CM; Delmas OM; Holt BA; Adams AB; Kwong GA
• DNA-Barcoded pMHC Tetramers for Detection of Single Antigen-Specific T Cells by Digital PCR.
  Anal Chem Volume: 91 Page(s): 2695 - 2700
  02/19/2019 Authors: Dahotre SN; Chang YM; Romanov AM; Kwong GA
• Hepatic Protease Expression in Patients with Nash Correlates with Fibrosis Stage and Treatment Response in a Phase 2 Trial of Selonsertib
  Volume: 68 Page(s): 736A - 736A
  10/01/2018 Authors: Warren A; Cazanave S; Huang EK; Kwong G; Diehl AM; Caldwell S; Charlton MR; Billin A; Zagorska A; Djedjos S
• Protease-Activated Nanosensors for Noininvasive Monitoring of Nash
  Volume: 68 Page(s): 734A - 734A
  10/01/2018 Authors: Warren A; Cazanave S; Huang EK; Kwong G; Luther J; Witkowski E; Hutter M; Chung RT; Corey KE; Bhatia S
• Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics.
  J Vis Exp
  07/16/2018 Authors: Holt BA; Mac QD; Kwong GA
• Activity Nanosensors for Early and Noninvasive Detection of Acute Organ Transplant Rejection.
  Volume: 18 Page(s): 399 - 400
  06/01/2018 Authors: Mac Q; Mathews D; Kahla J; Stoffers C; Delmas O; Holt B; Adams A; Kwong G
• Sensing T Cell Killing Activity with Granzyme B Activity Probes.
  Volume: 18 Page(s): 492 - 493
  06/01/2018 Authors: Mac Q; Mathews D; Kahla J; Stoffers C; Delmas O; Holt B; Adams A; Kwong G
• Individually addressable and dynamic DNA gates for multiplexed cell sorting.
  Proc Natl Acad Sci U S A Volume: 115 Page(s): 4357 - 4362
  04/24/2018 Authors: Dahotre SN; Chang YM; Wieland A; Stammen SR; Kwong GA
• Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains.
  ACS Synth Biol Volume: 7 Page(s): 1167 - 1173
  04/20/2018 Authors: Miller IC; Gamboa Castro M; Maenza J; Weis JP; Kwong GA
• Sustained-release synthetic biomarkers for monitoring thrombosis and inflammation using point-of-care compatible readouts.
  Adv Funct Mater Volume: 26 Page(s): 2919 - 2928
  05/03/2016 Authors: Dudani JS; Buss CG; Akana RTK; Kwong GA; Bhatia SN
• Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity.
  ACS Nano Volume: 9 Page(s): 11708 - 11717
  12/22/2015 Authors: Dudani JS; Jain PK; Kwong GA; Stevens KR; Bhatia SN
• Mathematical framework for activity-based cancer biomarkers.
  Proc Natl Acad Sci U S A Volume: 112 Page(s): 12627 - 12632
  10/13/2015 Authors: Kwong GA; Dudani JS; Carrodeguas E; Mazumdar EV; Zekavat SM; Bhatia SN
• Dual-Reporter Induced Pluripotent Stem Cells for Vascular Cell Sheet Engineering
  Volume: 21 Page(s): S225 - S225
  09/01/2015 Authors: Kwong G; Kotton DN; Wong JY
• Programmable probiotics for detection of cancer in urine.
  Sci Transl Med Volume: 7 Page(s): 289ra84
  05/27/2015 Authors: Danino T; Prindle A; Kwong GA; Skalak M; Li H; Allen K; Hasty J; Bhatia SN
• Regulation Of Airway Smooth Muscle Differentiation By Retinoic Acid In The Developing Airway
  Volume: 191
  01/01/2015 Authors: Marquez HA; Chen F; Cao Y; Kwong G; Kotton DN; Cardoso WV
• Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers.
  J Am Chem Soc Volume: 136 Page(s): 13709 - 13714
  10/01/2014 Authors: Warren AD; Gaylord ST; Ngan KC; Dumont Milutinovic M; Kwong GA; Bhatia SN; Walt DR
• Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade.
  ACS Nano Volume: 8 Page(s): 8776 - 8785
  09/23/2014 Authors: Lin KY; Lo JH; Consul N; Kwong GA; Bhatia SN
• Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics.
  Proc Natl Acad Sci U S A Volume: 111 Page(s): 3671 - 3676
  03/11/2014 Authors: Warren AD; Kwong GA; Wood DK; Lin KY; Bhatia SN
• Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.
  ACS Nano Volume: 7 Page(s): 9001 - 9009
  10/22/2013 Authors: Lin KY; Kwong GA; Warren AD; Wood DK; Bhatia SN
• Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease.
  Nat Biotechnol Volume: 31 Page(s): 63 - 70
  01/01/2013 Authors: Kwong GA; von Maltzahn G; Murugappan G; Abudayyeh O; Mo S; Papayannopoulos IA; Sverdlov DY; Liu SB; Warren AD; Popov Y
• Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1.
  J Am Chem Soc Volume: 133 Page(s): 18280 - 18288
  11/16/2011 Authors: Millward SW; Henning RK; Kwong GA; Pitram S; Agnew HD; Deyle KM; Nag A; Hein J; Lee SS; Lim J
• High-density, multiplexed patterning of cells at single-cell resolution for tissue engineering and other applications.
  Angew Chem Int Ed Engl Volume: 50 Page(s): 7378 - 7380
  08/01/2011 Authors: Vermesh U; Vermesh O; Wang J; Kwong GA; Ma C; Hwang K; Heath JR
• A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells.
  Nat Med Volume: 17 Page(s): 738 - 743
  06/01/2011 Authors: Ma C; Fan R; Ahmad H; Shi Q; Comin-Anduix B; Chodon T; Koya RC; Liu C-C; Kwong GA; Radu CG
• BIOL 9 - Nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells
  Volume: 238 Page(s): 871 - 871
  08/16/2009 Authors: Kwong GA; Radu C; Ribas A; Witte O; Heath JR
• Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells.
  J Am Chem Soc Volume: 131 Page(s): 9695 - 9703
  07/22/2009 Authors: Kwong GA; Radu CG; Hwang K; Shu CJ; Ma C; Koya RC; Comin-Anduix B; Hadrup SR; Bailey RC; Witte ON
• Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood.
  Nat Biotechnol Volume: 26 Page(s): 1373 - 1378
  12/01/2008 Authors: Fan R; Vermesh O; Srivastava A; Yen BKH; Qin L; Ahmad H; Kwong GA; Liu C-C; Gould J; Hood L
• Response rates to combination therapy for chronic HCV infection in a clinical setting and derivation of probability tables for individual patient management.
  J Viral Hepat Volume: 15 Page(s): 271 - 278
  04/01/2008 Authors: Thomson BJ; Kwong G; Ratib S; Sweeting M; Ryder SD; De Angelis D; Grieve R; Irving WL; Trent HCV Study Group
• DNA-encoded antibody libraries: a unified platform for multiplexed cell sorting and detection of genes and proteins.
  J Am Chem Soc Volume: 129 Page(s): 1959 - 1967
  02/21/2007 Authors: Bailey RC; Kwong GA; Radu CG; Witte ON; Heath JR
• Quantitative real-time measurements of DNA hybridization with alkylated nonoxidized silicon nanowires in electrolyte solution.
  J Am Chem Soc Volume: 128 Page(s): 16323 - 16331
  12/20/2006 Authors: Bunimovich YL; Shin YS; Yeo W-S; Amori M; Kwong G; Heath JR