Keith Wilkinson PhD

Department of Biochemistry
Professor Emeritus

(404) 727-2545
genekdw@emory.edu

Academic Appointment

Professor, Department of Biochemistry, Emory University School of Medicine

Education

Degrees

PhD from The University of Michigan
BA from Albion College

Research

Focus

Our laboratory concentrates on the regulation of protein amount and location in the cell. We are studying the ubiquitin-dependent proteolysis system that is responsible for regulated degradation of intracellular proteins as well as the role of ubiquitin and ubiquitin-like proteins as a targeting signal.

Publications

Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association.
Int J Mol Sci Volume: 21
07/16/2020 Authors: Chernova TA; Yang Z; Karpova TS; Shanks JR; Shcherbik N; Wilkinson KD; Chernoff YO
Yeast Models for Amyloids and Prions: Environmental Modulation and Drug Discovery.
Molecules Volume: 24
09/18/2019 Authors: Chernova TA; Chernoff YO; Wilkinson KD
Prion-based memory of heat stress in yeast.
Prion Volume: 11 Page(s): 151 - 161
05/04/2017 Authors: Chernova TA; Chernoff YO; Wilkinson KD
Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress.
Cell Rep Volume: 18 Page(s): 751 - 761
01/17/2017 Authors: Chernova TA; Kiktev DA; Romanyuk AV; Shanks JR; Laur O; Ali M; Ghosh A; Kim D; Yang Z; Mang M
Formation of a metastable stress-inducible prion by the yeast short-lived actin associated protein
PRION Volume: 10 Page(s): S66 - S67
01/01/2016 Authors: Chernova TA; Kiktev DA; Romanyuk AV; Shanks JR; Ali M; Ghosh A; Yang Z; Kim D; Mang M; Chernoff YO
Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates.
Elife Volume: 4
09/08/2015 Authors: Balakirev MY; Mullally JE; Favier A; Assard N; Sulpice E; Lindsey DF; Rulina AV; Gidrol X; Wilkinson KD
Formation of a Metastable Prion by the Yeast Actin Associated Protein Lsb2
Volume: 32 Page(s): S206 - S207
09/01/2015 Authors: Chernova TA; Shanks J; Chernoff YO; Wilkinson KD
Irwin Allan Rose (1926-2015) OBITUARY
NATURE Volume: 523 Page(s): 532 - 532
07/30/2015 Authors: Wilkinson K; Hershko A
Irwin Allan Rose (1926-2015).
Nature Volume: 523 Page(s): 532
07/30/2015 Authors: Wilkinson K; Hershko A
Irwin (Ernie) Allen Rose (1926-2015).
Cell Volume: 162 Page(s): 235 - 236
07/16/2015 Authors: Haas AL; Wilkinson K
Quantitative analysis of protein-protein interactions.
Methods Mol Biol Volume: 1278 Page(s): 23 - 37
01/01/2015 Authors: Eletr ZM; Wilkinson KD
Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion.
J Biol Chem Volume: 289 Page(s): 27625 - 27639
10/03/2014 Authors: Ali M; Chernova TA; Newnam GP; Yin L; Shanks J; Karpova TS; Lee A; Laur O; Subramanian S; Kim D
Racial/ethnic differences in clinical trial enrollment, refusal rates, ineligibility, and reasons for decline among patients at sites in the National Cancer Institute's Community Cancer Centers Program.
Cancer Volume: 120 Page(s): 877 - 884
03/01/2014 Authors: Langford AT; Resnicow K; Dimond EP; Denicoff AM; Germain DS; McCaskill-Stevens W; Enos RA; Carrigan A; Wilkinson K; Go RS
Physiological and environmental control of yeast prions.
FEMS Microbiol Rev Volume: 38 Page(s): 326 - 344
03/01/2014 Authors: Chernova TA; Wilkinson KD; Chernoff YO
Regulation of proteolysis by human deubiquitinating enzymes.
Biochim Biophys Acta Volume: 1843 Page(s): 114 - 128
01/01/2014 Authors: Eletr ZM; Wilkinson KD
BAP1 is phosphorylated at serine 592 in S-phase following DNA damage.
FEBS Lett Volume: 587 Page(s): 3906 - 3911
12/11/2013 Authors: Eletr ZM; Yin L; Wilkinson KD
Proteolytic processing of the actin assembly protein Lsb1 is stress dependent and modulates aggregation of other proteins
Volume: 30 Page(s): 62 - 62
09/01/2013 Authors: Chernova T; Ali M; Yin L; Newnam GP; Chernoff YO; Wilkinson KD
Integration of chaperone networks acting in stress defense, protein folding, trafficking and prion propagation
Volume: 280 Page(s): 227 - 228
07/01/2013 Authors: Chernoff Y; Kiktev D; Howie R; Newnam G; Chernova T; Ali M; Wilkinson K
Two ZnF-UBP domains in isopeptidase T (USP5).
Biochemistry Volume: 51 Page(s): 1188 - 1198
02/14/2012 Authors: Avvakumov GV; Walker JR; Xue S; Allali-Hassani A; Asinas A; Nair UB; Fang X; Zuo X; Wang Y-X; Wilkinson KD
Prion induction by the short-lived, stress-induced protein Lsb2 is regulated by ubiquitination and association with the actin cytoskeleton.
Mol Cell Volume: 43 Page(s): 242 - 252
07/22/2011 Authors: Chernova TA; Romanyuk AV; Karpova TS; Shanks JR; Ali M; Moffatt N; Howie RL; O'Dell A; McNally JG; Liebman SW
An emerging model for BAP1's role in regulating cell cycle progression.
Cell Biochem Biophys Volume: 60 Page(s): 3 - 11
06/01/2011 Authors: Eletr ZM; Wilkinson KD
Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.
EMBO Rep Volume: 12 Page(s): 350 - 357
04/01/2011 Authors: Ye Y; Akutsu M; Reyes-Turcu F; Enchev RI; Wilkinson KD; Komander D
Deubiquitinating enzymes as pharmacological targets: BRCA1 associated protein 1 (BAP1)
Volume: 241
03/27/2011 Authors: Wilkinson KD; Eletr Z; Bondesen B
Structure and recognition of polyubiquitin chains of different lengths and linkage.
F1000 Biol Rep Volume: 3 Page(s): 26
01/01/2011 Authors: Fushman D; Wilkinson KD
Distribution and paralogue specificity of mammalian deSUMOylating enzymes.
Biochem J Volume: 430 Page(s): 335 - 344
09/01/2010 Authors: Kolli N; Mikolajczyk J; Drag M; Mukhopadhyay D; Moffatt N; Dasso M; Salvesen G; Wilkinson KD
Identification and developmental expression of Xenopus laevis SUMO proteases.
PLoS One Volume: 4 Page(s): e8462
12/24/2009 Authors: Wang Y; Mukhopadhyay D; Mathew S; Hasebe T; Heimeier RA; Azuma Y; Kolli N; Shi Y-B; Wilkinson KD; Dasso M
DUBs at a glance.
J Cell Sci Volume: 122 Page(s): 2325 - 2329
07/15/2009 Authors: Wilkinson KD
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains.
EMBO Rep Volume: 10 Page(s): 466 - 473
05/01/2009 Authors: Komander D; Reyes-Turcu F; Licchesi JDF; Odenwaelder P; Wilkinson KD; Barford D
Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.
Proc Natl Acad Sci U S A Volume: 106 Page(s): 6650 - 6655
04/21/2009 Authors: Shenoy SK; Modi AS; Shukla AK; Xiao K; Berthouze M; Ahn S; Wilkinson KD; Miller WE; Lefkowitz RJ
Polyubiquitin binding and disassembly by deubiquitinating enzymes.
Chem Rev Volume: 109 Page(s): 1495 - 1508
04/01/2009 Authors: Reyes-Turcu FE; Wilkinson KD
Burkholderia mallei tssM encodes a putative deubiquitinase that is secreted and expressed inside infected RAW 264.7 murine macrophages.
Infect Immun Volume: 77 Page(s): 1636 - 1648
04/01/2009 Authors: Shanks J; Burtnick MN; Brett PJ; Waag DM; Spurgers KB; Ribot WJ; Schell MA; Panchal RG; Gherardini FC; Wilkinson KD
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1.
J Mol Biol Volume: 386 Page(s): 1011 - 1023
03/06/2009 Authors: Wang T; Yin L; Cooper EM; Lai M-Y; Dickey S; Pickart CM; Fushman D; Wilkinson KD; Cohen RE; Wolberger C
Dynamic compartmentalization of base excision repair proteins in response to nuclear and mitochondrial oxidative stress.
Mol Cell Biol Volume: 29 Page(s): 794 - 807
02/01/2009 Authors: Griffiths LM; Swartzlander D; Meadows KL; Wilkinson KD; Corbett AH; Doetsch PW
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.
Annu Rev Biochem Volume: 78 Page(s): 363 - 397
01/01/2009 Authors: Reyes-Turcu FE; Ventii KH; Wilkinson KD
Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.
J Cell Biol Volume: 183 Page(s): 589 - 595
11/17/2008 Authors: Yun C; Wang Y; Mukhopadhyay D; Backlund P; Kolli N; Yergey A; Wilkinson KD; Dasso M
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).
Biochem J Volume: 415 Page(s): 367 - 375
11/01/2008 Authors: Drag M; Mikolajczyk J; Bekes M; Reyes-Turcu FE; Ellman JA; Wilkinson KD; Salvesen GS
Protein partners of deubiquitinating enzymes.
Biochem J Volume: 414 Page(s): 161 - 175
09/01/2008 Authors: Ventii KH; Wilkinson KD
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization.
Cancer Res Volume: 68 Page(s): 6953 - 6962
09/01/2008 Authors: Ventii KH; Devi NS; Friedrich KL; Chernova TA; Tighiouart M; Van Meir EG; Wilkinson KD
Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T.
J Biol Chem Volume: 283 Page(s): 19581 - 19592
07/11/2008 Authors: Reyes-Turcu FE; Shanks JR; Komander D; Wilkinson KD
Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities.
Protein Sci Volume: 17 Page(s): 1035 - 1043
06/01/2008 Authors: Nicholson B; Leach CA; Goldenberg SJ; Francis DM; Kodrasov MP; Tian X; Shanks J; Sterner DE; Bernal A; Mattern MR
DeTEKting ubiquitination of APC/C substrates.
Cell Volume: 133 Page(s): 570 - 572
05/16/2008 Authors: Haas AL; Wilkinson KD
Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein.
J Biol Chem Volume: 283 Page(s): 11038 - 11049
04/18/2008 Authors: Messick TE; Russell NS; Iwata AJ; Sarachan KL; Shiekhattar R; Shanks JR; Reyes-Turcu FE; Wilkinson KD; Marmorstein R
OTU takes the chains OUT.
Nat Chem Biol Volume: 4 Page(s): 227 - 228
04/01/2008 Authors: Balakirev MY; Wilkinson KD
Prion formation in yeast is influenced by alterations of the ubiquitin proteolysis
FASEB JOURNAL Volume: 22
04/01/2008 Authors: Chernova TA; Allen KD; Chernoff YO; Wilkinson KD
Para log specificity of mammalian SENPs for SUMO-1 and SUMO-2
FASEB JOURNAL Volume: 22
04/01/2008 Authors: Kolli N; Mikolajczyk J; Mukhopadhyay D; Dasso M; Salvesen G; Wilkinson KD
Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63.
J Virol Volume: 81 Page(s): 6007 - 6018
06/01/2007 Authors: Chen Z; Wang Y; Ratia K; Mesecar AD; Wilkinson KD; Baker SC
Effects of ubiquitin system alterations on the formation and loss of a yeast prion.
J Biol Chem Volume: 282 Page(s): 3004 - 3013
02/02/2007 Authors: Allen KD; Chernova TA; Tennant EP; Wilkinson KD; Chernoff YO
SUSP1 antagonizes formation of highly SUMO2/3-conjugated species.
J Cell Biol Volume: 174 Page(s): 939 - 949
09/25/2006 Authors: Mukhopadhyay D; Ayaydin F; Kolli N; Tan S-H; Anan T; Kametaka A; Azuma Y; Wilkinson KD; Dasso M
Cecile Pickart - 1954-2006
CELL Volume: 125 Page(s): 635 - 637
05/19/2006 Authors: Finley D; Wilkinson KD
The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin.
Cell Volume: 124 Page(s): 1197 - 1208
03/24/2006 Authors: Reyes-Turcu FE; Horton JR; Mullally JE; Heroux A; Cheng X; Wilkinson KD
Identification of mammalian SUMO-specific ubiquitin-like processing proteases (SENP/Ulp)
Volume: 20 Page(s): A1370 - A1370
03/07/2006 Authors: Kolli N; Wilkinson KD
Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain
Volume: 20 Page(s): A1353 - A1353
03/07/2006 Authors: Mullally JE; Chernova T; Wilkinson KD
The ZnFUBP domain is a novel ubiquitin-binding domain that recognizes the C-terminal di-glycine motif of unanchored ubiquitin
Volume: 20 Page(s): A476 - A476
03/06/2006 Authors: Reyes-Turcu FE; Horton JR; Cheng XD; Wilkinson KD
Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain.
Mol Cell Biol Volume: 26 Page(s): 822 - 830
02/01/2006 Authors: Mullally JE; Chernova T; Wilkinson KD
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
EMBO J Volume: 24 Page(s): 3747 - 3756
11/02/2005 Authors: Hu M; Li P; Song L; Jeffrey PD; Chenova TA; Wilkinson KD; Cohen RE; Shi Y
The discovery of ubiquitin-dependent proteolysis.
Proc Natl Acad Sci U S A Volume: 102 Page(s): 15280 - 15282
10/25/2005 Authors: Wilkinson KD
The ubiquitin signal: assembly, recognition and termination. Symposium on ubiquitin and signaling.
EMBO Rep Volume: 6 Page(s): 815 - 820
09/01/2005 Authors: Wilkinson KD; Ventii KH; Friedrich KL; Mullally JE
Novel effects of ubiquitin system and chaperone proteins on the prion "life cycle" in yeast
Volume: 272 Page(s): 152 - 152
07/01/2005 Authors: Chernova TA; Allen KD; Tennant EP; Wilkinson KD; Chernoff YO
Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.
Oncogene Volume: 24 Page(s): 3319 - 3327
05/05/2005 Authors: Chen C; Sun X; Ran Q; Wilkinson KD; Murphy TJ; Simons JW; Dong J-T
Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI+].
Genetics Volume: 169 Page(s): 1227 - 1242
03/01/2005 Authors: Allen KD; Wegrzyn RD; Chernova TA; Mller S; Newnam GP; Winslett PA; Wittich KB; Wilkinson KD; Chernoff YO
Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1.
J Mol Biol Volume: 345 Page(s): 141 - 151
01/07/2005 Authors: Reverter D; Wu K; Erdene TG; Pan Z-Q; Wilkinson KD; Lima CD
Derivitization of the C-terminus of ubiquitin and ubiquitin-like proteins using intein chemistry: methods and uses.
Methods Enzymol Volume: 399 Page(s): 37 - 51
01/01/2005 Authors: Wilkinson KD; Gan-Erdene T; Kolli N
Deubiquitinating enzyme purification, assay inhibitors, and characterization.
Methods Mol Biol Volume: 301 Page(s): 207 - 219
01/01/2005 Authors: Russell NS; Wilkinson KD
Ubiquitin: a Nobel protein.
Cell Volume: 119 Page(s): 741 - 745
12/17/2004 Authors: Wilkinson KD
Varshavsky's contributions.
Science Volume: 306 Page(s): 1290 - 1292
11/19/2004 Authors: Baumeister W; Bachmair A; Chau V; Cohen R; Coffino P; Demartino G; Deshaies R; Dohmen J; Emr S; Finley D
Modulating huntingtin half-life alters polyglutamine-dependent aggregate formation and cell toxicity.
J Neurochem Volume: 89 Page(s): 962 - 973
05/01/2004 Authors: Kaytor MD; Wilkinson KD; Warren ST
Identification of a novel 29-linked polyubiquitin binding protein, Ufd3, using polyubiquitin chain analogues.
Biochemistry Volume: 43 Page(s): 4844 - 4854
04/27/2004 Authors: Russell NS; Wilkinson KD
Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of free ubiquitin pool (vol 278, pg 52102, 2003)
JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 279 Page(s): 16894 - 16894
04/16/2004 Authors: Chernova TA; Allen KD; Wesoloski LM; Shanks JR; Chernoff YO; Wilkinson KD
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function.
J Biol Chem Volume: 279 Page(s): 8506 - 8515
02/27/2004 Authors: Olzmann JA; Brown K; Wilkinson KD; Rees HD; Huai Q; Ke H; Levey AI; Li L; Chin L-S
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins.
Mol Cell Biol Volume: 24 Page(s): 84 - 95
01/01/2004 Authors: Hemelaar J; Borodovsky A; Kessler BM; Reverter D; Cook J; Kolli N; Gan-Erdene T; Wilkinson KD; Gill G; Lima CD
Quantitative analysis of protein-protein interactions.
Methods Mol Biol Volume: 261 Page(s): 15 - 32
01/01/2004 Authors: Wilkinson KD
Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool.
J Biol Chem Volume: 278 Page(s): 52102 - 52115
12/26/2003 Authors: Chernova TA; Allen KD; Wesoloski LM; Shanks JR; Chernoff YO; Wilkinson KD
ISG15 conjugation and release: A novel antiviral host response in endothelial cells.
Volume: 102 Page(s): 278A - 279A
11/16/2003 Authors: Kaufman JL; Kaiser WJ; Wilkinson KD; Hassel BA; Offermann MK
General competencies are intrinsic to emergency medicine training: a multicenter study.
Acad Emerg Med Volume: 10 Page(s): 1049 - 1053
10/01/2003 Authors: Reisdorff EJ; Hayes OW; Reynolds B; Wilkinson KC; Overton DT; Wagner MJ; Kowalenko T; Portelli D; Walker G; Carlson D
Signal transduction: aspirin, ubiquitin and cancer.
Nature Volume: 424 Page(s): 738 - 739
08/14/2003 Authors: Wilkinson KD
DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1.
J Biol Chem Volume: 278 Page(s): 28882 - 28891
08/01/2003 Authors: Wu K; Yamoah K; Dolios G; Gan-Erdene T; Tan P; Chen A; Lee C-G; Wei N; Wilkinson KD; Wang R
Identification and characterization of DEN1, a deneddylase of the ULP family.
J Biol Chem Volume: 278 Page(s): 28892 - 28900
08/01/2003 Authors: Gan-Erdene T; Nagamalleswari K; Yin L; Wu K; Pan Z-Q; Wilkinson KD
Deubiquitinating enzymes in the pathogenesis of neurodegenerative diseases: the view from the yeast system.
Volume: 20 Page(s): S298 - S298
07/01/2003 Authors: Chernova TA; Allen KD; Shanks JR; Chernoff YO; Wilkinson KD
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.
Chem Biol Volume: 9 Page(s): 1149 - 1159
10/01/2002 Authors: Borodovsky A; Ovaa H; Kolli N; Gan-Erdene T; Wilkinson KD; Ploegh HL; Kessler BM
Cell biology: unchaining the condemned.
Nature Volume: 419 Page(s): 351 - 353
09/26/2002 Authors: Wilkinson KD
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome.
Cell Volume: 107 Page(s): 477 - 487
11/16/2001 Authors: Brown V; Jin P; Ceman S; Darnell JC; O'Donnell WT; Tenenbaum SA; Jin X; Feng Y; Wilkinson KD; Keene JD
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.
EMBO J Volume: 20 Page(s): 5187 - 5196
09/17/2001 Authors: Borodovsky A; Kessler BM; Casagrande R; Overkleeft HS; Wilkinson KD; Ploegh HL
Divergent N-terminal sequences of a deubiquitinating enzyme modulate substrate specificity.
J Biol Chem Volume: 276 Page(s): 20357 - 20363
06/08/2001 Authors: Lin H; Yin L; Reid J; Wilkinson KD; Wing SS
The fragile X mental retardation protein inhibits translation via interacting with mRNA.
Nucleic Acids Res Volume: 29 Page(s): 2276 - 2283
06/01/2001 Authors: Li Z; Zhang Y; Ku L; Wilkinson KD; Warren ST; Feng Y
Development and characterization of a unique set of anti-FMRP antibodies using a novel strategy.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 67 Page(s): 200 - 200
10/01/2000 Authors: Ceman SS; Kenneson A; Nelson R; Jin C; Lakkis L; Brown V; Wilkinson K; Warren ST
Nonhydrolyzable diubiquitin analogues are inhibitors of ubiquitin conjugation and deconjugation.
Biochemistry Volume: 39 Page(s): 10001 - 10010
08/15/2000 Authors: Yin L; Krantz B; Russell NS; Deshpande S; Wilkinson KD
Functional consequence of substitutions at residue 171 in human galactose-1-phosphate uridylyltransferase.
J Biol Chem Volume: 275 Page(s): 22847 - 22853
07/28/2000 Authors: Crews C; Wilkinson KD; Wells L; Perkins C; Fridovich-Keil JL
Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome.
Semin Cell Dev Biol Volume: 11 Page(s): 141 - 148
06/01/2000 Authors: Wilkinson KD
Ubiquitin-dependent signaling: the role of ubiquitination in the response of cells to their environment.
J Nutr Volume: 129 Page(s): 1933 - 1936
11/01/1999 Authors: Wilkinson KD
The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3.
J Mol Biol Volume: 291 Page(s): 1067 - 1077
09/03/1999 Authors: Wilkinson KD; Laleli-Sahin E; Urbauer J; Larsen CN; Shih GH; Haas AL; Walsh ST; Wand AJ
The ubiquitin pathway in Parkinson's disease.
Nature Volume: 395 Page(s): 451 - 452
10/01/1998 Authors: Leroy E; Boyer R; Auburger G; Leube B; Ulm G; Mezey E; Harta G; Brownstein MJ; Jonnalagada S; Chernova T
Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein.
J Biol Chem Volume: 273 Page(s): 15521 - 15527
06/19/1998 Authors: Brown V; Small K; Lakkis L; Feng Y; Gunter C; Wilkinson KD; Warren ST
Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases.
Biochemistry Volume: 37 Page(s): 3358 - 3368
03/10/1998 Authors: Larsen CN; Krantz BA; Wilkinson KD
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.
Oncogene Volume: 16 Page(s): 1097 - 1112
03/05/1998 Authors: Jensen DE; Proctor M; Marquis ST; Gardner HP; Ha SI; Chodosh LA; Ishov AM; Tommerup N; Vissing H; Sekido Y
Regulation of ubiquitin-dependent processes by deubiquitinating enzymes.
FASEB J Volume: 11 Page(s): 1245 - 1256
12/01/1997 Authors: Wilkinson KD
Purification and characterization of the fragile X mental retardation protein.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 61 Page(s): A26 - A26
10/01/1997 Authors: Brown VL; Small K; Lakkis L; Wilkinson KD; Warren ST
Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths.
J Biol Chem Volume: 272 Page(s): 23712 - 23721
09/19/1997 Authors: Piotrowski J; Beal R; Hoffman L; Wilkinson KD; Cohen RE; Pickart CM
In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome.
EMBO J Volume: 16 Page(s): 4826 - 4838
08/15/1997 Authors: Amerik AYu; Swaminathan S; Krantz BA; Wilkinson KD; Hochstrasser M
Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution.
EMBO J Volume: 16 Page(s): 3787 - 3796
07/01/1997 Authors: Johnston SC; Larsen CN; Cook WJ; Wilkinson KD; Hill CP
Functional requirements of the active site position 185 in the human enzyme galactose-1-phosphate uridylyltransferase.
J Biol Chem Volume: 271 Page(s): 26835 - 26842
10/25/1996 Authors: Quimby BB; Wells L; Wilkinson KD; Fridovich-Keil JL
Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T.
Biochemistry Volume: 34 Page(s): 14535 - 14546
11/07/1995 Authors: Wilkinson KD; Tashayev VL; O'Connor LB; Larsen CN; Kasperek E; Pickart CM
Roles of ubiquitinylation in proteolysis and cellular regulation.
Annu Rev Nutr Volume: 15 Page(s): 161 - 189
01/01/1995 Authors: Wilkinson KD
FMR1 protein: conserved RNP family domains and selective RNA binding.
Science Volume: 262 Page(s): 563 - 566
10/22/1993 Authors: Ashley CT; Wilkinson KD; Reines D; Warren ST
FMR-1 IS A RNA-BINDING PROTEIN WITH 2 HIGHLY CONSERVED FUNCTIONAL DOMAINS
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 53 Page(s): 41 - 41
09/01/1993 Authors: ASHLEY CT; WILKINSON KD; WARREN ST
Cloning and analysis of expression of a ubiquitin carboxyl terminal hydrolase expressed during oogenesis in Drosophila melanogaster.
Dev Biol Volume: 157 Page(s): 214 - 223
05/01/1993 Authors: Zhang N; Wilkinson K; Bownes M
HUMAN GENES CONTAINING POLYMORPHIC TRINUCLEOTIDE REPEATS (VOL 2, PG 186, 1992)
NATURE GENETICS Volume: 3 Page(s): 273 - 273
03/01/1993 Authors: RIGGINS GJ; LOKEY LK; CHASTIN JL; LEINER HA; SHERMAN SL; WILKINSON KD; WARREN ST
Human genes containing polymorphic trinucleotide repeats.
Nat Genet Volume: 2 Page(s): 186 - 191
11/01/1992 Authors: Riggins GJ; Lokey LK; Chastain JL; Leiner HA; Sherman SL; Wilkinson KD; Warren ST
Comparisons of neuronal (PGP 9.5) and non-neuronal ubiquitin C-terminal hydrolases.
Biochem Soc Trans Volume: 20 Page(s): 631 - 637
08/01/1992 Authors: Wilkinson KD; Deshpande S; Larsen CN
A specific inhibitor of the ubiquitin activating enzyme: synthesis and characterization of adenosyl-phospho-ubiquitinol, a nonhydrolyzable ubiquitin adenylate analogue.
Biochemistry Volume: 29 Page(s): 7373 - 7380
08/14/1990 Authors: Wilkinson KD; Smith SE; O'Connor L; Sternberg E; Taggart JJ; Berges DA; Butt T
Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.
J Pathol Volume: 161 Page(s): 153 - 160
06/01/1990 Authors: Lowe J; McDermott H; Landon M; Mayer RJ; Wilkinson KD
UBIQUITIN CARBOXYL-TERMINAL HYDROLASE (PGP9.5) IS SELECTIVELY PRESENT IN UBIQUITINATED INCLUSION-BODIES CHARACTERISTIC OF HUMAN NEURODEGENERATIVE DISEASE
NEUROBIOLOGY OF AGING Volume: 11 Page(s): 281 - 282
05/01/1990 Authors: MAYER RJ; MCDERMOTT H; LANDON M; LOWE J; WILKINSON KD
Detection and inhibition of ubiquitin-dependent proteolysis.
Methods Enzymol Volume: 185 Page(s): 387 - 397
01/01/1990 Authors: Wilkinson KD
Probing the structure of processed antigen by using biotin and avidin. MHC-dependent inhibition of responses to selected biotinyl-insulin derivatives.
J Immunol Volume: 143 Page(s): 3423 - 3429
12/01/1989 Authors: Jensen PE; Wilkinson KD
The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase.
Science Volume: 246 Page(s): 670 - 673
11/03/1989 Authors: Wilkinson KD; Lee KM; Deshpande S; Duerksen-Hughes P; Boss JM; Pohl J
Affinity chromatography using protein immobilized via arginine residues: purification of ubiquitin carboxyl-terminal hydrolases.
Biochemistry Volume: 28 Page(s): 8530 - 8536
10/17/1989 Authors: Duerksen-Hughes PJ; Williamson MM; Wilkinson KD
Detection, resolution, and nomenclature of multiple ubiquitin carboxyl-terminal esterases from bovine calf thymus.
Biochemistry Volume: 28 Page(s): 166 - 172
01/10/1989 Authors: Mayer AN; Wilkinson KD
Racemization of individual amino acid residues in membrane proteins.
Prog Clin Biol Res Volume: 292 Page(s): 487 - 496
01/01/1989 Authors: Shapira R; Wilkinson KD; Shapira G
Racemization of individual aspartate residues in human myelin basic protein.
J Neurochem Volume: 50 Page(s): 649 - 654
02/01/1988 Authors: Shapira R; Wilkinson KD; Shapira G
Structure and function of ubiquitin: evidence for differential interactions of arginine-74 with the activating enzyme and the proteases of ATP-dependent proteolysis.
Biochemistry Volume: 26 Page(s): 6980 - 6987
11/03/1987 Authors: Duerksen-Hughes PJ; Xu XX; Wilkinson KD
Protein ubiquitination: a regulatory post-translational modification.
Anticancer Drug Des Volume: 2 Page(s): 211 - 229
10/01/1987 Authors: Wilkinson KD
Comparison of the three-dimensional structures of human, yeast, and oat ubiquitin.
J Biol Chem Volume: 262 Page(s): 6396 - 6399
05/05/1987 Authors: Vijay-Kumar S; Bugg CE; Wilkinson KD; Vierstra RD; Hatfield PM; Cook WJ
NONENZYMATIC SYNTHESIS OF UBIQUITIN-PROTEIN CONJUGATES AND UBIQUITIN C-TERMINAL DERIVATIVES
FEDERATION PROCEEDINGS Volume: 46 Page(s): 2086 - 2086
05/01/1987 Authors: WILKINSON KD; MARRIOTT D; CHAU V
PROBING THE SUBSTRATE-SPECIFICITY OF PROTEIN UBIQUITINATION
FEDERATION PROCEEDINGS Volume: 46 Page(s): 2087 - 2087
05/01/1987 Authors: MARRIOTT D; WILKINSON KD; CHAU V
Immobilization of proteins via arginine residues.
Anal Biochem Volume: 160 Page(s): 444 - 454
02/01/1987 Authors: Duerksen PJ; Wilkinson KD
Role of ubiquitin conformations in the specificity of protein degradation: iodinated derivatives with altered conformations and activities.
Arch Biochem Biophys Volume: 250 Page(s): 400 - 409
11/01/1986 Authors: Cox MJ; Haas AL; Wilkinson KD
Alcohol-induced conformational changes of ubiquitin.
Arch Biochem Biophys Volume: 250 Page(s): 390 - 399
11/01/1986 Authors: Wilkinson KD; Mayer AN
Synthesis and characterization of ubiquitin ethyl ester, a new substrate for ubiquitin carboxyl-terminal hydrolase.
Biochemistry Volume: 25 Page(s): 6644 - 6649
10/21/1986 Authors: Wilkinson KD; Cox MJ; Mayer AN; Frey T
Structure and activities of a variant ubiquitin sequence from bakers' yeast.
Biochemistry Volume: 25 Page(s): 4999 - 5004
09/09/1986 Authors: Wilkinson KD; Cox MJ; O'Connor LB; Shapira R
SYNTHESIS AND CHARACTERIZATION OF THE CARBOXYL-TERMINAL ETHYL-ESTER OF UBIQUITIN
FEDERATION PROCEEDINGS Volume: 45 Page(s): 1599 - 1599
05/01/1986 Authors: WILKINSON KD; COX MJ; MAYER AN; FREY T
4-(OXYACETYL)PHENOXYACETIC ACID, A NEWLY CHARACTERIZED, BIFUNCTIONAL ARGININE-MODIFICATION REAGENT
FEDERATION PROCEEDINGS Volume: 45 Page(s): 1541 - 1541
05/01/1986 Authors: DUERKSEN PJ; WILKINSON KD
Tryptic peptide mapping of ubiquitin and derivatives using reverse-phase high performance liquid chromatography.
Anal Biochem Volume: 154 Page(s): 345 - 352
04/01/1986 Authors: Cox MJ; Shapira R; Wilkinson KD
Ubiquitin-dependent proteolysis of native and alkylated bovine serum albumin: effects of protein structure and ATP concentration on selectivity.
Biochemistry Volume: 24 Page(s): 2915 - 2923
06/04/1985 Authors: Evans AC; Wilkinson KD
Three-dimensional structure of ubiquitin at 2.8 A resolution.
Proc Natl Acad Sci U S A Volume: 82 Page(s): 3582 - 3585
06/01/1985 Authors: Vijay-Kumar S; Bugg CE; Wilkinson KD; Cook WJ
AN INVESTIGATION OF THE CONTRIBUTION OF MASCULINITY TO DELINQUENT-BEHAVIOR
SOCIOLOGICAL FOCUS Volume: 18 Page(s): 249 - 263
01/01/1985 Authors: WILKINSON K
DAUGHTERS OF THE STATE - A SOCIAL PORTRAIT OF THE 1ST REFORM SCHOOL FOR GIRLS IN NORTH-AMERICA, 1856-1905 - BRENZEL,BM
SOCIOLOGY AND SOCIAL RESEARCH Volume: 69 Page(s): 277 - 278
01/01/1985 Authors: WILKINSON K
125I-ubiquitin is kinetically invalid as a tracer radiolabel for studies of ATP-dependent proteolysis.
Prog Clin Biol Res Volume: 180 Page(s): 211 - 213
01/01/1985 Authors: Wilkinson KD; Cox MJ
The large scale purification of ubiquitin from human erythrocytes.
Prep Biochem Volume: 15 Page(s): 49 - 60
01/01/1985 Authors: Haas AL; Wilkinson KD
Gentamicin diffusion across hydrogel bandage lenses and its kinetic distribution on the eye.
Curr Eye Res Volume: 3 Page(s): 977 - 989
08/01/1984 Authors: McCarey BE; Schmidt FH; Wilkinson KD; Baum JP
SUBSTRATE-SPECIFICITY OF UBIQUITIN-DEPENDENT PROTEIN-DEGRADATION
FEDERATION PROCEEDINGS Volume: 42 Page(s): 1813 - 1813
01/01/1983 Authors: WILKINSON KD; EVANS AC
Study of crystalline hexokinase-glucose complexes by isotope trapping.
J Biol Chem Volume: 256 Page(s): 9890 - 9894
10/10/1981 Authors: Wilkinson KD; Rose IA
Stimulation of ATP-dependent proteolysis requires ubiquitin with the COOH-terminal sequence Arg-Gly-Gly.
J Biol Chem Volume: 256 Page(s): 9235 - 9241
09/10/1981 Authors: Wilkinson KD; Audhya TK
NADH inhibition and NAD activation of Escherichia coli lipoamide dehydrogenase catalyzing the NADH-lipoamide reaction.
J Biol Chem Volume: 256 Page(s): 2307 - 2314
03/10/1981 Authors: Wilkinson KD; Williams CH
Glucose exchange and catalysis by two crystalline hexokinase x glucose complexes. Evidence for an obligatory ATP-dependent conformational change in catalysis.
J Biol Chem Volume: 255 Page(s): 7569 - 7574
08/25/1980 Authors: Wilkinson KD; Rose IA
Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes.
J Biol Chem Volume: 255 Page(s): 7529 - 7532
08/25/1980 Authors: Wilkinson KD; Urban MK; Haas AL
A suggestion for naming faces of ring compounds.
Proc Natl Acad Sci U S A Volume: 77 Page(s): 2439 - 2441
05/01/1980 Authors: Rose IA; Hanson KR; Wilkinson KD; Wimmer MJ
UBIQUITIN IS THE ATP-DEPENDENT PROTEOLYSIS FACTOR-I OF RABBIT RETICULOCYTES
FEDERATION PROCEEDINGS Volume: 39 Page(s): 1682 - 1682
01/01/1980 Authors: WILKINSON KD; URBAN MK
Isotope trapping studies of yeast hexokinase during steady state catalysis. A combined rapid quench and isotope trapping technique.
J Biol Chem Volume: 254 Page(s): 12567 - 12572
12/25/1979 Authors: Wilkinson KD; Rose IA
Activation of yeast hexokinase PII. Changes in conformation and association.
J Biol Chem Volume: 254 Page(s): 2125 - 2131
03/25/1979 Authors: Wilkinson KD; Rose IA
Interactions of guanidinium chloride and pyridine nucleotides with oxidized and two-electron-reduced lipoamide dehydrogenase from Escherichia coli.
J Biol Chem Volume: 254 Page(s): 863 - 871
02/10/1979 Authors: Wilkinson KD; Williams CH
Evidence for multiple electronic forms of two-electron-reduced lipoamide dehydrogenase from Escherichia coli.
J Biol Chem Volume: 254 Page(s): 852 - 862
02/10/1979 Authors: Wilkinson KD; Williams CH
ISOTOPE TRAPPING AND CATALYTIC COMPETENCE OF 2 CRYSTALLINE HEXOKINASE-GLUCOSE COMPLEXES
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Page(s): 29 - 29
01/01/1979 Authors: WILKINSON KD; ROSE IA
Methodology employed for anaerobic spectrophotometric titrations and for computer-assisted data analysis.
Methods Enzymol Volume: 62 Page(s): 185 - 198
01/01/1979 Authors: Williams CH; Arscott LD; Matthews RG; Thorpe C; Wilkinson KD
An -N-acetyl-D-glycosamine binding lectin from Bandeiraea simplicifolia seeds.
Arch Biochem Biophys Volume: 177 Page(s): 330 - 333
11/01/1976 Authors: Lyer PN; Wilkinson KD; Goldstein LJ
EVIDENCE FOR MULTIPLE ELECTRONIC STATES IN 2 ELECTRON REDUCED LIPOAMIDE DEHYDROGENASE FROM ESCHERICHIA-COLI
FEDERATION PROCEEDINGS Volume: 35 Page(s): 1534 - 1534
01/01/1976 Authors: WILKINSON KD; WILLIAMS CH

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Keith Wilkinson PhD

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