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Profile

Gregory Damhorst

  • Department of Medicine
    Assistant Professor
  • gregory.damhorst@emory.edu

Overview

Physician-scientist bioengineer with clinical subspecialty in infectious diseases and research focus on the development and validation of diagnostic technologies. The Damhorst lab is developing novel assays to characterize the host-pathogen interaction in Staphylococcus aureus bloodstream infections while supporting the activities and research of the Investigational Clinical Microbiology Core (ICMC) in the Department of Medicine, Emory Center for the Advancement of Diagnostics for a Just Society (ADJUST Center), and the Atlanta Center for Microsystems Engineered Point-of-Care Technologies (ACME POCT) primarily through the NIH Rapid Acceleration of Diagnostics (RADx) initiative and related activities.

Research

Publications

  • Diagnostic Utility of SARS-CoV-2 Nucleocapsid Antigenemia: A Meta-analysis.
    Open Forum Infect Dis Volume: 11 Page(s): ofae561
    10/01/2024 Authors: Damhorst GL; Martin SE; Wilber E; Verkerke H; Goodman M; Lam WA
  • Protocol for the creation and characterization of SARS-CoV-2 variant testing panels using remnant clinical samples for diagnostic assay testing.
    STAR Protoc Volume: 5 Page(s): 103146
    09/20/2024 Authors: Bassit L; Bowers HB; Greenleaf M; Sabino C; Lai E; Yu G; Piantadosi A; Wang E; O'Sick W; McLendon K
  • Performance of the Xpert Mpox PCR assay with oropharyngeal, anorectal, and cutaneous lesion swab specimens.
    J Clin Virol Volume: 171 Page(s): 105659
    04/01/2024 Authors: Damhorst GL; McLendon K; Morales E; Solis ZM; Fitts E; Bowers HB; Sabino C; Sullivan J; Greenleaf M; Roback JD
  • Comparison of RT-PCR and antigen test sensitivity across nasopharyngeal, nares, and oropharyngeal swab, and saliva sample types during the SARS-CoV-2 omicron variant.
    Heliyon Volume: 10 Page(s): e27188
    03/30/2024 Authors: Damhorst GL; Lin J; Frediani JK; Sullivan JA; Westbrook A; McLendon K; Baugh TJ; O'Sick WH; Roback JD; Piantadosi AL
  • Multisite Mpox Infection and Viral Dynamics Among Persons With HIV in Metro Atlanta.
    J Infect Dis Volume: 229 Page(s): S213 - S218
    03/26/2024 Authors: Damhorst GL; Fujita AW; Fitts E; Szabo B; Bowers HB; Sabino C; Ahmed A; Wang E; Piantadosi A; McLendon K
  • Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against Wuhan-WT, delta and omicron BA1, BA2 spike trimers.
    iScience Volume: 26 Page(s): 108256
    11/17/2023 Authors: Cheedarla N; Verkerke HP; Potlapalli S; McLendon KB; Patel A; Frank F; O'Sick WH; Cheedarla S; Baugh TJ; Damhorst GL
  • Use of Natural Language Processing of Patient-Initiated Electronic Health Record Messages to Identify Patients With COVID-19 Infection.
    JAMA Netw Open Volume: 6 Page(s): e2322299
    07/03/2023 Authors: Mermin-Bunnell K; Zhu Y; Hornback A; Damhorst G; Walker T; Robichaux C; Mathew L; Jaquemet N; Peters K; Johnson TM
  • Pivot, persevere, or perish: how Ellume Health overcame development and regulatory obstacles to become the first authorized over-the-counter COVID-19 test in the United States.
    Lab Chip Volume: 23 Page(s): 2366 - 2370
    05/16/2023 Authors: Greenleaf MN; Nehl E; Damhorst GL; Lam WA
  • Investigation of Blood Plasma Viral Nucleocapsid Antigen as a Marker of Active Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Infection.
    Open Forum Infect Dis Volume: 10 Page(s): ofad226
    05/01/2023 Authors: Damhorst GL; Schoof N; Nguyen P-V; Verkerke H; Wilber E; McLendon K; O'Sick W; Baugh T; Cheedarla S; Cheedarla N
  • SARS-CoV-2 Antigenemia is Associated With Pneumonia in Children But Lacks Sensitivity to Diagnose Acute Infection.
    Pediatr Infect Dis J Volume: 42 Page(s): 130 - 135
    02/01/2023 Authors: Damhorst GL; Verkerke HP; Harrington KRV; McLendon K; Lu A; Perez MA; Hussaini L; Anderson EJ; Stowell SR; Roback JD
  • Effect of swab pooling on the Accula point-of-care RT-PCR for SARS-CoV-2 detection.
    Front Microbiol Volume: 14 Page(s): 1219214
    01/01/2023 Authors: Lancelot M; Fibben K; Sullivan J; O'Sick W; McLendon K; Wu H; Rao A; Bassit LC; Greenleaf M; Miller P
  • Nucleocapsid Antigenemia Is a Marker of Acute SARS-CoV-2 Infection.
    J Infect Dis Volume: 226 Page(s): 1577 - 1587
    11/01/2022 Authors: Verkerke HP; Damhorst GL; Graciaa DS; McLendon K; O'Sick W; Robichaux C; Cheedarla N; Potlapalli S; Wu S-C; Harrington KRV
  • Nucleocapsid Antigenemia in Patients Receiving Anti-CD20 Therapy With Protracted COVID-19.
    Open Forum Infect Dis Volume: 9 Page(s): ofac419
    08/01/2022 Authors: Wilber E; Piantadosi A; Babiker A; McLendon K; O'Sick W; Fitts E; Webster AS; Verkerke H; Kim JS; Phadke VK
  • Don't forget about human factors: Lessons learned from COVID-19 point-of-care testing.
    Cell Rep Methods Volume: 2 Page(s): 100222
    05/23/2022 Authors: Farmer S; Razin V; Peagler AF; Strickler S; Fain WB; Damhorst GL; Kempker RR; Pollock NR; Brand O; Seitter B
  • Designing for simplicity: lessons from Mesa Biotech for microfluidic entrepreneurs and early-stage companies.
    Lab Chip Volume: 22 Page(s): 1469 - 1473
    04/12/2022 Authors: Greenleaf MN; Damhorst GL; Ku DN; Nehl EJ; Tyburski EA; Brand O; Martin GS; Lam WA
  • Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against native-like vaccine and delta variant spike trimers.
    Res Sq
    02/16/2022 Authors: Cheedarla N; Verkerke HP; Potlapalli S; McLendon KB; Patel A; Frank F; Damhorst GL; Wu H; O'Sick WH; Graciaa D
  • Where is Omicron? Comparison of SARS-CoV-2 RT-PCR and Antigen Test Sensitivity at Commonly Sampled Anatomic Sites Over the Course of Disease.
    medRxiv
    02/09/2022 Authors: Lin J; Frediani JK; Damhorst GL; Sullivan JA; Westbrook A; McLendon K; Baugh TJ; O'Sick WH; Roback JD; Piantadosi AL
  • Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against native-like vaccine and delta variant spike trimers.
    medRxiv
    02/02/2022 Authors: Cheedarla N; Verkerke HP; Potlapalli S; McLendon KB; Patel A; Frank F; Damhorst GL; Wu H; O Sick WH; Graciaa D
  • Acanthamoeba castellanii encephalitis in a patient with AIDS: a case report and literature review.
    Lancet Infect Dis Volume: 22 Page(s): e59 - e65
    02/01/2022 Authors: Damhorst GL; Watts A; Hernandez-Romieu A; Mel N; Palmore M; Ali IKM; Neill SG; Kalapila A; Cope JR
  • Acanthamoeba castellanii encephalitis in a patient with AIDS a case report and literature review
    LANCET INFECTIOUS DISEASES Volume: 22 Page(s): E59 - E65
    02/01/2022 Authors: Damhorst GL; Watts A; Hernandez-Romieu A; Mel N; Palmore M; Ali IKM; Neill SG; Kalapila A; Cope JR; Palmore M
  • Clinical Utilization of DiaSorin Molecular Polymerase Chain Reaction in Pneumocystis Pneumonia.
    Open Forum Infect Dis Volume: 9 Page(s): ofab634
    01/01/2022 Authors: Damhorst GL; Broder KJ; Overton EC; Rara R; Busch LM; Burd EM; Webster AS; Kraft CS; Babiker A
  • Diagnostic and prognostic capabilities of a biomarker and EMR-based machine learning algorithm for sepsis.
    Clin Transl Sci Volume: 14 Page(s): 1578 - 1589
    07/01/2021 Authors: Taneja I; Damhorst GL; Lopez-Espina C; Zhao SD; Zhu R; Khan S; White K; Kumar J; Vincent A; Yeh L
  • Current Capabilities of Gut Microbiome-Based Diagnostics and the Promise of Clinical Application.
    J Infect Dis Volume: 223 Page(s): S270 - S275
    06/16/2021 Authors: Damhorst GL; Adelman MW; Woodworth MH; Kraft CS
  • Publisher Correction: Combining Biomarkers with EMR Data to Identify Patients in Different Phases of Sepsis.
    Sci Rep Volume: 9 Page(s): 17419
    11/19/2019 Authors: Taneja I; Reddy B; Damhorst G; Zhao SD; Hassan U; Price Z; Jensen T; Ghonge T; Patel M; Wachspress S
  • Diagnosis of acute serious illness: the role of point-of-care technologies.
    Curr Opin Biomed Eng Volume: 11 Page(s): 22 - 34
    09/01/2019 Authors: Damhorst GL; Tyburski EA; Brand O; Martin GS; Lam WA
  • Smartphone-imaged microfluidic biochip for measuring CD64 expression from whole blood.
    Analyst Volume: 144 Page(s): 3925 - 3935
    07/07/2019 Authors: Ghonge T; Ceylan Koydemir H; Valera E; Berger J; Garcia C; Nawar N; Tiao J; Damhorst GL; Ganguli A; Hassan U
  • Pixelated spatial gene expression analysis from tissue.
    Nat Commun Volume: 9 Page(s): 202
    01/15/2018 Authors: Ganguli A; Ornob A; Spegazzini N; Liu Y; Damhorst G; Ghonge T; Thornton B; Konopka CJ; Dobrucki W; Clare SE
  • A microfluidic technique to estimate antigen expression on particles.
    APL Bioeng Volume: 1 Page(s): 016103
    12/01/2017 Authors: Ghonge T; Ganguli A; Valera E; Saadah M; Damhorst GL; Berger J; Pagan Diaz G; Hassan U; Chheda M; Haidry Z
  • Combining Biomarkers with EMR Data to Identify Patients in Different Phases of Sepsis.
    Sci Rep Volume: 7 Page(s): 10800
    09/07/2017 Authors: Taneja I; Reddy B; Damhorst G; Dave Zhao S; Hassan U; Price Z; Jensen T; Ghonge T; Patel M; Wachspress S
  • Hands-free smartphone-based diagnostics for simultaneous detection of Zika, Chikungunya, and Dengue at point-of-care.
    Biomed Microdevices Volume: 19 Page(s): 73
    08/22/2017 Authors: Ganguli A; Ornob A; Yu H; Damhorst GL; Chen W; Sun F; Bhuiya A; Cunningham BT; Bashir R
  • HIV-1 IIIB capture from whole blood on magnetic microparticles.
    Annu Int Conf IEEE Eng Med Biol Soc Volume: 2016 Page(s): 5785 - 5788
    08/01/2016 Authors: Damhorst GL; Kooiman JM; Bashir R
  • Microfluidic differential immunocapture biochip for specific leukocyte counting.
    Nat Protoc Volume: 11 Page(s): 714 - 726
    04/01/2016 Authors: Hassan U; Watkins NN; Reddy B; Damhorst G; Bashir R
  • A microfluidic biochip for complete blood cell counts at the point-of-care.
    Technology (Singap World Sci) Volume: 3 Page(s): 201 - 213
    12/01/2015 Authors: Hassan U; Reddy B; Damhorst G; Sonoiki O; Ghonge T; Yang C; Bashir R
  • Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip from Whole Blood.
    Engineering (Beijing) Volume: 1 Page(s): 324 - 335
    09/01/2015 Authors: Damhorst GL; Duarte-Guevara C; Chen W; Ghonge T; Cunningham BT; Bashir R
  • Graphene-Based Platform for Infrared Near-Field Nanospectroscopy of Water and Biological Materials in an Aqueous Environment.
    ACS Nano Volume: 9 Page(s): 7968 - 7975
    08/25/2015 Authors: Khatib O; Wood JD; McLeod AS; Goldflam MD; Wagner M; Damhorst GL; Koepke JC; Doidge GP; Rangarajan A; Bashir R
  • Microfluidic CD4+ and CD8+ T lymphocyte counters for point-of-care HIV diagnostics using whole blood.
    Sci Transl Med Volume: 5 Page(s): 214ra170
    12/04/2013 Authors: Watkins NN; Hassan U; Damhorst G; Ni H; Vaid A; Rodriguez W; Bashir R
  • A liposome-based ion release impedance sensor for biological detection.
    Biomed Microdevices Volume: 15 Page(s): 895 - 905
    10/01/2013 Authors: Damhorst GL; Smith CE; Salm EM; Sobieraj MM; Ni H; Kong H; Bashir R
  • Micro- and nanotechnology for HIV/AIDS diagnostics in resource-limited settings.
    IEEE Trans Biomed Eng Volume: 60 Page(s): 715 - 726
    03/01/2013 Authors: Damhorst GL; Watkins NN; Bashir R
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