Guiying Cui PhD

Department of Pediatrics
Assistant Professor

(404) 727-7352
gcui2@emory.edu

Emory University
Emory University
2015 Uppergate drive

Education

Degrees

PhD from China Medical University
MD from China Medical University
MD from Yanbian Medical College

Research

Focus

In the past 2 and half years, I have focused on the CFTR pore structure and function relationship project, including to probe the interhelices and intrahelices amino acids interaction by using site-directed mutagenesis, patch clamp, immuoprecipitation and immunohistogram techniques.

Publications

Effects of hyperglycemia on airway epithelial barrier function in WT and CF 16HBE cells.
Sci Rep Volume: 14 Page(s): 25095
10/23/2024 Authors: Vazquez Cegla AJ; Jones KT; Cui G; Cottrill KA; Koval M; McCarty NA
Chronic hyperglycemia aggravates lung function in a Scnn1b-Tg murine model.
Am J Physiol Lung Cell Mol Physiol Volume: 327 Page(s): L473 - L486
10/01/2024 Authors: Cui G; Moustafa DA; Zhao S; Cegla AV; Lyles JT; Goldberg JB; Chandler JD; McCarty NA
Development of a programmable automated cell culture system to study the lung pathophysiology of Cystic Fibrosis-related diabetes.
Heliyon Volume: 10 Page(s): e37977
09/30/2024 Authors: Vazquez Cegla AJ; Hedden C; Imhoff BR; Cui G; McCarty NA
Comparing ATPase activity of ATP-binding cassette subfamily C member 4, lamprey CFTR, and human CFTR using an antimony-phosphomolybdate assay.
Front Pharmacol Volume: 15 Page(s): 1363456
01/01/2024 Authors: Cui G; Strickland KM; Vazquez Cegla AJ; McCarty NA
Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function.
Nat Commun Volume: 14 Page(s): 6214
10/05/2023 Authors: Raya-Sandino A; Lozada-Soto KM; Rajagopal N; Garcia-Hernandez V; Luissint A-C; Brazil JC; Cui G; Koval M; Parkos CA; Nangia S
A transistor model for the cystic fibrosis transmembrane conductance regulator.
Biophys Rep (N Y) Volume: 3 Page(s): 100108
06/14/2023 Authors: Hunt WD; McCarty NA; Marin EM; Westafer RS; Yamin PR; Cui G; Eckford AW; Denison DR
Permissive and nonpermissive channel closings inCFTR revealed by a factor graph inference algorithm.
Biophys Rep (N Y) Volume: 2 Page(s): 100083
12/14/2022 Authors: Moffett AS; Cui G; Thomas PJ; Hunt WD; McCarty NA; Westafer RS; Eckford AW
Alteration of Membrane Cholesterol Content Plays a Key Role in Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Channel Activity.
Front Physiol Volume: 12 Page(s): 652513
01/01/2021 Authors: Cui G; Cottrill KA; Strickland KM; Mashburn SA; Koval M; McCarty NA
Electrophysiological Approaches for the Study of Ion Channel Function.
Methods Mol Biol Volume: 2302 Page(s): 49 - 67
01/01/2021 Authors: Cui G; Cottrill KA; McCarty NA
HYPERGLYCEMIC CONDITIONS DYSREGULATE BARRIER AND CHANNEL FUNCTION IN HUMAN CYSTIC FIBROSIS BRONCHIAL EPITHELIA
Volume: 55 Page(s): S47 - S47
10/01/2020 Authors: Cui G; Cottrill KA; Strickland K; Mashburn SA; Koval M; McCarty NA
Alteration of Membrane Cholesterol Content Plays a Key Role in Regulation of CFTR Channel Activity
Volume: 118 Page(s): 588A - 588A
02/07/2020 Authors: Cui G; Cottrill KA; Strickland KM; Imhoff BR; McCarty NA
An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters.
Dev Cell Volume: 51 Page(s): 421 - 430.e3
11/18/2019 Authors: Cui G; Hong J; Chung-Davidson Y-W; Infield D; Xu X; Li J; Simhaev L; Khazanov N; Stauffer B; Imhoff B
HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CHANNEL FUNCTION IS REGULATED BY CHOLESTEROL
Volume: 54 Page(s): S202 - S202
10/01/2019 Authors: Cui G; Cottrill KA; Strickland K; Imhoff B; McCarty NA
LAMPREY CFTR: AN ANCIENT CFTR ORTHOLOG INFORMS MOLECULAR EVOLUTION IN ABC TRANSPORTERS
Volume: 54 Page(s): S195 - S195
10/01/2019 Authors: Cui G; Hong JS; Chung-Davidson Y; Infield D; Xu X; Simhaev L; Khazanov N; Stauffer BB; Imhoff B; Cottrill KA
VX-770-mediated potentiation of numerous human CFTR disease mutants is influenced by phosphorylation level.
Sci Rep Volume: 9 Page(s): 13460
09/17/2019 Authors: Cui G; Stauffer BB; Imhoff BR; Rab A; Hong JS; Sorscher EJ; McCarty NA
ATP-Dependent Signaling in Simulations of a Revised Model of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
J Phys Chem B Volume: 123 Page(s): 3177 - 3188
04/18/2019 Authors: Strickland KM; Stock G; Cui G; Hwang H; Infield DT; Schmidt-Krey I; McCarty NA; Gumbart JC
Human CFTR Channel Function is Regulated by Cholesterol
Volume: 116 Page(s): 249A - 249A
02/15/2019 Authors: Cui G; Cottrill KA; McGill KA; Imhoff B; McCarty NA
CFTR PHOSPHORYLATION LEVEL MODULATES THE EFFICACY OF VX-770-MEDIATED POTENTIATION OF NUMEROUS HUMAN CFTR DISEASE-ASSOCIATED VARIANTS
Volume: 53 Page(s): 110 - 111
09/01/2018 Authors: Cui G; Stauffer BB; Imhoff B; Rab A; Hong JS; Sorscher EJ; McCarty NA
Machine-Learning-Based Classification of Low-Grade and High-Grade Glioblastoma Using Radiomic Features in Multiparametric MRI
Volume: 45 Page(s): E617 - E617
06/01/2018 Authors: Cui G; Jeong J; Lei Y; Wang T; Dong X; Liu T; Curran W; Mao H; Yang X
LAMPREY CFTR, AN EVOLUTIONARY ANCESTOR OF HUMAN CFTR, EXHIBITS NUMEROUS BIOPHYSICAL DISSIMILARITIES FROM HUMAN CFTR
Volume: 52 Page(s): S224 - S224
09/01/2017 Authors: Cui G; Hong JS; Stauffer B; Imhoff BR; Gaggar A; McCarty NA
Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR).
Sci Rep Volume: 7 Page(s): 2931
06/07/2017 Authors: Stauffer BB; Cui G; Cottrill KA; Infield DT; McCarty NA
Hemichorea caused by nonketotic hyperosmolar state: A case report and review of the literature.
Somatosens Mot Res Volume: 34 Page(s): 44 - 46
03/01/2017 Authors: Raza HK; Jing J; Cui G; Liang X; Hua F; Zhang Z; Tang H; Shi H; Chen H
MyD88 contributes to neuroinflammatory responses induced by cerebral ischemia/reperfusion in mice.
Biochem Biophys Res Commun Volume: 480 Page(s): 69 - 74
11/04/2016 Authors: Ye X; Kong D; Wang J; Ishrat T; Shi H; Ding X; Cui G; Hua F
S. AUREUS SPHINGOMYELINASE IS A STATE-DEPENDENT INHIBITOR OF CFTR
PEDIATRIC PULMONOLOGY Volume: 51 Page(s): 232 - 233
10/01/2016 Authors: Stauffer B; Cui G; Infield DT; McCarty NA
NOVEL POTENTIATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR IDENTIFIED WITH PHARMACOPHORE MODELING AND EXPERIMENTAL SCREENING
PEDIATRIC PULMONOLOGY Volume: 51 Page(s): 203 - 203
10/01/2016 Authors: Cui G; Khazanov N; Imhoff B; Senderowitz H; McCarty NA
Potentiators exert distinct effects on human, murine, and Xenopus CFTR.
Am J Physiol Lung Cell Mol Physiol Volume: 311 Page(s): L192 - L207
08/01/2016 Authors: Cui G; Khazanov N; Stauffer BB; Infield DT; Imhoff BR; Senderowitz H; McCarty NA
Positioning of extracellular loop 1 affects pore gating of the cystic fibrosis transmembrane conductance regulator.
Am J Physiol Lung Cell Mol Physiol Volume: 310 Page(s): L403 - L414
03/01/2016 Authors: Infield DT; Cui G; Kuang C; McCarty NA
CFTR Potentiators Exert Different Effects on Human, Murine, and Xenopus CFTR
Volume: 110 Page(s): 452A - 452A
02/16/2016 Authors: Cui G; Khazanov N; Stauffer BB; Infield DT; Imhoff BR; Senderowitz H; McCarty NA
COMPARATIVE MOLECULAR PHARMACOLOGY OF CFTR: TOWARD THE IDENTIFICATION OF NOVEL POTENTIATORS AND THEIR BINDING SITES
PEDIATRIC PULMONOLOGY Volume: 50 Page(s): 208 - 208
10/01/2015 Authors: Cui G; Khazanov N; Senderowitz H; McCarty NA
PHOSPHORYLATION SITES IN THE R DOMAIN IN MURINE CFTR EXHIBIT POWERFUL INHIBITORY FUNCTIONS ON CHANNEL ACTIVATION
PEDIATRIC PULMONOLOGY Volume: 50 Page(s): 207 - 207
10/01/2015 Authors: Cui G; Imhoff BR; McCarty NA
Murine and human CFTR exhibit different sensitivities to CFTR potentiators.
Am J Physiol Lung Cell Mol Physiol Volume: 309 Page(s): L687 - L699
10/01/2015 Authors: Cui G; McCarty NA
Positioning of the First Extracellular Loop of CFTR Has Significant Effects on CFTR Gating
Volume: 108 Page(s): 441A - 441A
01/27/2015 Authors: Infield DT; Cui G; Kuang C; McCarty NA
Inhibition of the CFTR Chloride Channel by Sphingomyelinase
Volume: 108 Page(s): 435A - 435A
01/27/2015 Authors: Stauffer B; Cui G; Infield DT; McCarty N
Refinement and Evaluation of a CFTR Homology Model and Identification of Residues Controlling Channel Gating
BIOPHYSICAL JOURNAL Volume: 108 Page(s): 127A - 127A
01/27/2015 Authors: Stock G; Cui G; McCarty NA; Gumbart JC
POSITIONING OF THE FIRST EXTRACELLULAR LOOP OF CFTR HAS SIGNIFICANT EFFECTS ON CFTR GATING
PEDIATRIC PULMONOLOGY Volume: 49 Page(s): 233 - 233
09/01/2014 Authors: Infield DT; Cui G; Kuang C; McCarty NA
MURINE CFTR BEHAVIOR DIFFERS FROM HUMAN CFTR IN DISTINCT ASPECTS
PEDIATRIC PULMONOLOGY Volume: 49 Page(s): 226 - 226
09/01/2014 Authors: Cui G; Prince C; McCarty NA
Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR.
J Gen Physiol Volume: 144 Page(s): 159 - 179
08/01/2014 Authors: Cui G; Rahman KS; Infield DT; Kuang C; Prince CZ; McCarty NA
Identification of novel MicroRNA signatures linked to experimental autoimmune myasthenia gravis pathogenesis: down-regulated miR-145 promotes pathogenetic Th17 cell response.
J Neuroimmune Pharmacol Volume: 8 Page(s): 1287 - 1302
12/01/2013 Authors: Wang J; Zheng S; Xin N; Dou C; Fu L; Zhang X; Chen J; Zhang Y; Geng D; Xiao C
THREE CHARGED AMINO ACIDS IN THE OUTER VESTIBULE OF CFTR STABILIZE THE OPEN PORE ARCHITECTURE
PEDIATRIC PULMONOLOGY Volume: 48 Page(s): 219 - 219
10/01/2013 Authors: Cui G; Kuang C; Rahman KS; Prince CZ; McCarty NA
MOLECULAR MODELING AND SIMULATIONS OF CHANNEL OPENING IN CFTR
PEDIATRIC PULMONOLOGY Volume: 48 Page(s): 220 - 220
10/01/2013 Authors: Rahman K; Cui G; Harvey SC; McCarty NA
THE STRUCTURAL AND FUNCTIONAL IMPORTANCE OF TYPE II DIVERGENT AMINO ACIDS IN THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
PEDIATRIC PULMONOLOGY Volume: 48 Page(s): 219 - 219
10/01/2013 Authors: Cui G; Wang J; Kuang C; Rahman KS; Prince CZ; Jordan IK; McCarty NA
Three Charged Amino Acids in the Outer Vestibule of CFTR Stabilize the Open Pore Architecture
Volume: 142 Page(s): 5A - 6A
08/01/2013 Authors: Cui G; Kuang C; Rahman KS; Prince CZ; Mccarty NA
Two salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.
J Biol Chem Volume: 288 Page(s): 20758 - 20767
07/12/2013 Authors: Cui G; Freeman CS; Knotts T; Prince CZ; Kuang C; McCarty NA
Expression of interleukin-22 in myasthenia gravis.
Scand J Immunol Volume: 78 Page(s): 98 - 107
07/01/2013 Authors: Zheng S; Dou C; Xin N; Wang J; Wang J; Li P; Fu L; Shen X; Cui G; Dong R
Modeling the conformational changes underlying channel opening in CFTR.
PLoS One Volume: 8 Page(s): e74574
01/01/2013 Authors: Rahman KS; Cui G; Harvey SC; McCarty NA
EXTRACELLULAR LOOP 1 IS INVOLVED IN MAINTAINING OUTER VESTIBULE PORE ARCHITECTURE OF CFTR
PEDIATRIC PULMONOLOGY Volume: 47 Page(s): 237 - 238
09/01/2012 Authors: Cui G; Kuang C; Prince CZ; McCarty NA
TARGETED MOLECULAR DYNAMICS SIMULATIONS OF THE CFTR GATING CYCLE
PEDIATRIC PULMONOLOGY Volume: 47 Page(s): 244 - 244
09/01/2012 Authors: Rahman K; Cui G; McCarty NA; Harvey SC
Differential contribution of TM6 and TM12 to the pore of CFTR identified by three sulfonylurea-based blockers.
Pflugers Arch Volume: 463 Page(s): 405 - 418
03/01/2012 Authors: Cui G; Song B; Turki HW; McCarty NA
Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters.
Proc Natl Acad Sci U S A Volume: 105 Page(s): 18865 - 18870
12/02/2008 Authors: Jordan IK; Kota KC; Cui G; Thompson CH; McCarty NA
The best disease-linked Cl- channel hBest1 regulates Ca V 1 (L-type) Ca2+ channels via src-homology-binding domains.
J Neurosci Volume: 28 Page(s): 5660 - 5670
05/28/2008 Authors: Yu K; Xiao Q; Cui G; Lee A; Hartzell HC
Mutations at arginine 352 alter the pore architecture of CFTR.
J Membr Biol Volume: 222 Page(s): 91 - 106
03/01/2008 Authors: Cui G; Zhang Z-R; O'Brien ARW; Song B; McCarty NA
Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells.
J Physiol Volume: 585 Page(s): 791 - 803
12/15/2007 Authors: Cui G; Meyer AC; Calin-Jageman I; Neef J; Haeseleer F; Moser T; Lee A
Phosphorylation of the Ca2+-binding protein CaBP4 by protein kinase C zeta in photoreceptors.
J Neurosci Volume: 27 Page(s): 12743 - 12754
11/14/2007 Authors: Lee A; Jimenez A; Cui G; Haeseleer F
Attenuation of streptomycin ototoxicity by tetramethylpyrazine and its effect on K channels in the outer hair cells of guinea pig cochlea.
Sheng Li Xue Bao Volume: 59 Page(s): 534 - 538
08/25/2007 Authors: Tang H; Cui G-Y; Shi L-J; Gao Q-H; Cao Y
The block of CFTR by scorpion venom is state-dependent.
Biophys J Volume: 89 Page(s): 3960 - 3975
12/01/2005 Authors: Fuller MD; Zhang Z-R; Cui G; McCarty NA
Determination of the functional unit of the cystic fibrosis transmembrane conductance regulator chloride channel. One polypeptide forms one pore.
J Biol Chem Volume: 280 Page(s): 458 - 468
01/07/2005 Authors: Zhang Z-R; Cui G; Liu X; Song B; Dawson DC; McCarty NA
Mutations at arginine 352 alter the pore architecture of CFTR
Volume: 88 Page(s): 612A - 612A
01/01/2005 Authors: Cui GY; Song BL; McCarty NA
The block of CFTR by scorpion venom is state dependent
Volume: 88 Page(s): 611A - 611A
01/01/2005 Authors: Fuller MD; Zhang ZR; Cui GY; McCarty NA
Inhibition of CFTR channels by a peptide toxin of scorpion venom.
Am J Physiol Cell Physiol Volume: 287 Page(s): C1328 - C1341
11/01/2004 Authors: Fuller MD; Zhang Z-R; Cui G; Kubanek J; McCarty NA
Time-dependent interactions of glibenclamide with CFTR: kinetically complex block of macroscopic currents.
J Membr Biol Volume: 201 Page(s): 139 - 155
10/01/2004 Authors: Zhang Z-R; Cui G; Zeltwanger S; McCarty NA
CFTR: One pore channel
Volume: 86 Page(s): 586A - 586A
01/01/2004 Authors: Zhang ZR; Cui GY; Song BL; Liu XH; Dawson DC; McCarty NA
Differential block of CFTR pore by three members of the sulphonylurea family
Volume: 86 Page(s): 586A - 586A
01/01/2004 Authors: Cui GY; Song BL; McCarty NA
Inhibition of CFTR channels by a peptide toxin of scorpion venom
Volume: 122 Page(s): 23A - 23A
07/01/2003 Authors: Fuller MD; Zhang ZR; Cui GY; Mccarty NA
CFTR channel inhibition by a peptide toxin of scorpion venom
Volume: 84 Page(s): 82A - 83A
02/01/2003 Authors: Fuller MD; Zhang ZR; Cui GY; McCarty NA
Probing a new mechanism of glibenclamide interation with CFTR: gating efffects
Volume: 84 Page(s): 83A - 83A
02/01/2003 Authors: Cui GY; McCarty NA
Analgesic domains of interferon-alpha.
Neuroreport Volume: 12 Page(s): 857 - 859
03/26/2001 Authors: Wang YX; Cui GY; Shen J; Huang AJ; Liu XY; Chen YZ; Jiang CL

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Guiying Cui PhD

Education

Degrees

Research

Focus

Publications