Graeme Conn PhD

Department of Biochemistry
Professor

Emory University School of Medicine
Department of Biochemsitry
1510 Clifton Rd., Room 4031 RRC

Overview

Molecular studies of RNA/protein structure and interactions in bacterial antibiotic resistance and RNA-mediated regulation of the human innate immune response.

Academic Appointment

Professor, Biochemistry, Emory University School of Medicine

Education

Degrees

Ph.D. from University of Edinburgh
B.Sc. from University of Edinburgh

Research

Focus

We use a combination of biochemical, biophysical and molecular structural approaches to study the mechanisms by which proteins and nucleic acids identify their targets, interact with them and thereby carry out their biological function(s).

Publications

Regulation, structure, and activity of the Pseudomonas aeruginosa MexXY efflux system.
Antimicrob Agents Chemother Volume: 69 Page(s): e0182524
04/07/2025 Authors: Kavanaugh LG; Hinrichsen ME; Dunham CM; Conn GL
Determination of Pseudomonas aeruginosa MexXY-OprM substrate profile in a major efflux knockout system reveals distinct antibiotic substrate classes.
Microbiol Spectr Volume: 13 Page(s): e0290324
03/04/2025 Authors: Kavanaugh LG; Hariharan SM; Conn GL
Evading resistance at the double.
Nat Chem Biol Volume: 20 Page(s): 1555 - 1556
12/01/2024 Authors: Barmada MI; Conn GL
Determination of Pseudomonas aeruginosa MexXY-OprM substrate profile in a major efflux knockout system reveals distinct antibiotic substrate classes.

11/20/2024 Authors: Kavanaugh LG; Hariharan SM; Conn GL
DISTANT RIBOSE 2'-O-METHYLATION OF 23S rRNA HELIX 69 PRE-ORDERS THE CAPREOMYCIN DRUG BINDING POCKET AT THE RIBOSOME SUBUNIT INTERFACE.

11/05/2024 Authors: Nandi S; Dey D; Srinivas P; Dunham CM; Conn GL
Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistance.
Microbiol Mol Biol Rev Volume: 88 Page(s): e0008923
09/26/2024 Authors: Kavanaugh LG; Dey D; Shafer WM; Conn GL
Ensuring a sustained workforce to combat antibiotic resistance in the 21st century: the critical need for training the next-gen of scientists at the pre-doctoral level.
Antimicrob Agents Chemother Volume: 68 Page(s): e0024424
06/05/2024 Authors: Shafer WM; Conn GL
AI is a viable alternative to high throughput screening: a 318-target study.
Sci Rep Volume: 14 Page(s): 7526
04/02/2024 Authors: Atomwise AIMS Program
tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10.
J Biol Chem Volume: 299 Page(s): 105443
12/01/2023 Authors: Strassler SE; Bowles IE; Krishnamohan A; Kim H; Edgington CB; Kuiper EG; Hancock CJ; Comstock LR; Jackman JE; Conn GL
tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10.
bioRxiv
10/19/2023 Authors: Strassler SE; Bowles IE; Krishnamohan A; Kim H; Edgington CB; Kuiper EG; Hancock CJ; Comstock LR; Jackman JE; Conn GL
Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition.
NPJ Antimicrob Resist Volume: 1 Page(s): 12
10/06/2023 Authors: Kavanaugh LG; Mahoney AR; Dey D; Wuest WM; Conn GL
Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition.
bioRxiv
09/19/2023 Authors: Kavanaugh LG; Mahoney AR; Dey D; Wuest WM; Conn GL
30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC.
Proc Natl Acad Sci U S A Volume: 120 Page(s): e2304128120
06/20/2023 Authors: Srinivas P; Nosrati M; Zelinskaya N; Dey D; Comstock LR; Dunham CM; Conn GL
30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC.
bioRxiv
04/30/2023 Authors: Srinivas P; Nosrati M; Zelinskaya N; Dey D; Comstock LR; Dunham CM; Conn GL
Ribosome-targeting antibiotics and resistance via ribosomal RNA methylation.
RSC Med Chem Volume: 14 Page(s): 624 - 643
04/26/2023 Authors: Jeremia L; Deprez BE; Dey D; Conn GL; Wuest WM
Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2-dependent ISR in C9ORF72 FTD/ALS.
Elife Volume: 12
04/19/2023 Authors: Parameswaran J; Zhang N; Braems E; Tilahun K; Pant DC; Yin K; Asress S; Heeren K; Banerjee A; Davis E
Tied up in knots: Untangling substrate recognition by the SPOUT methyltransferases.
J Biol Chem Volume: 298 Page(s): 102393
10/01/2022 Authors: Strassler SE; Bowles IE; Dey D; Jackman JE; Conn GL
50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA.
Proc Natl Acad Sci U S A Volume: 119 Page(s): e2120352119
04/05/2022 Authors: Laughlin ZT; Nandi S; Dey D; Zelinskaya N; Witek MA; Srinivas P; Nguyen HA; Kuiper EG; Comstock LR; Dunham CM
Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs.
Proc Natl Acad Sci U S A Volume: 119
01/18/2022 Authors: Schwartz SL; Dey D; Tanquary J; Bair CR; Lowen AC; Conn GL
Tuberactinomycin antibiotics: Biosynthesis, anti-mycobacterial action, and mechanisms of resistance.
Front Microbiol Volume: 13 Page(s): 961921
01/01/2022 Authors: Laughlin ZT; Conn GL
Targeted Redesign of Suramin Analogs for Novel Antimicrobial Lead Development.
J Chem Inf Model Volume: 61 Page(s): 4442 - 4454
09/27/2021 Authors: Dey D; Ramakumar S; Conn GL
Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency.
Sci Immunol Volume: 6
06/18/2021 Authors: Magg T; Okano T; Koenig LM; Boehmer DFR; Schwartz SL; Inoue K; Heimall J; Licciardi F; Ley-Zaporozhan J; Ferdman RM
BASIS OF SUBSTRATE PREFERENCE IN THE PSEUDOMONAS EFFLUX SYSTEMS MEXY AND MEXB
Volume: 55 Page(s): S166 - S167
10/01/2020 Authors: Dey D; Kavanaugh LG; Conn GL
Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs.
Nucleic Acids Res Volume: 48 Page(s): 7520 - 7531
07/27/2020 Authors: Schwartz SL; Park EN; Vachon VK; Danzy S; Lowen AC; Conn GL
Antibiotic Substrate Selectivity of Pseudomonas aeruginosa MexY and MexB Efflux Systems Is Determined by a Goldilocks Affinity.
Antimicrob Agents Chemother Volume: 64
07/22/2020 Authors: Dey D; Kavanaugh LG; Conn GL
Aminoglycoside conformation and ring substituents dictate evasion from bacterial resistance mechanisms
Volume: 34
04/01/2020 Authors: Dey D; Hoffer E; Francis D; Dunham C; Conn G
Ribosomal Protein L11 Selectively Stabilizes a Tertiary Structure of the GTPase Center rRNA Domain.
J Mol Biol Volume: 432 Page(s): 991 - 1007
02/14/2020 Authors: Welty R; Rau M; Pabit S; Dunstan MS; Conn GL; Pollack L; Hall KB
Substrate recognition by the Pseudomonas aeruginosa EF-Tu-modifying methyltransferase EftM.
J Biol Chem Volume: 294 Page(s): 20109 - 20121
12/27/2019 Authors: Kuiper EG; Dey D; LaMore PA; Owings JP; Prezioso SM; Goldberg JB; Conn GL
Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition.
J Biol Chem Volume: 294 Page(s): 17642 - 17653
11/15/2019 Authors: Nosrati M; Dey D; Mehrani A; Strassler SE; Zelinskaya N; Hoffer ED; Stagg SM; Dunham CM; Conn GL
Dysregulation of M segment gene expression contributes to influenza A virus host restriction.
PLoS Pathog Volume: 15 Page(s): e1007892
08/01/2019 Authors: Calderon BM; Danzy S; Delima GK; Jacobs NT; Ganti K; Hockman MR; Conn GL; Lowen AC; Steel J
RNA regulation of the antiviral protein 2'-5'-oligoadenylate synthetase.
Wiley Interdiscip Rev RNA Volume: 10 Page(s): e1534
07/01/2019 Authors: Schwartz SL; Conn GL
Trimethylation of Elongation Factor-Tu by the Dual Thermoregulated Methyltransferase EftM Does Not Impact Its Canonical Function in Translation.
Sci Rep Volume: 9 Page(s): 3553
03/05/2019 Authors: Prezioso SM; Duong DM; Kuiper EG; Deng Q; Albert S; Conn GL; Goldberg JB
Heterozygous OAS1 Mutations Cause Spontaneous RNA Cleavage and Apoptosis with Resulting Multisystem Inflammation and Immunodeficiency
Volume: 39 Page(s): S23 - S23
02/01/2019 Authors: Heimall J; Magg T; Sullivan KE; Albert M; Griese M; Conway D; Gray PE; Calderon B; Conn G; Klein C
Editorial: Bacterial Mechanisms of Antibiotic Resistance: A Structural Perspective.
Front Mol Biosci Volume: 6 Page(s): 71
01/01/2019 Authors: Conn GL; Bavro VN; Davies C
Application of Isothermal Titration Calorimetry (ITC) to Biomolecular Interactions
Page(s): 279 - 305
01/01/2019 Authors: Conn GL
A human cellular noncoding RNA activates the antiviral protein 2'-5'-oligoadenylate synthetase 1.
J Biol Chem Volume: 293 Page(s): 16115 - 16124
10/12/2018 Authors: Calderon BM; Conn GL
Substrate Recognition and Modification by a Pathogen-Associated Aminoglycoside Resistance 16S rRNA Methyltransferase.
Antimicrob Agents Chemother Volume: 61
05/01/2017 Authors: Vinal K; Conn GL
A Cellular Non-coding RNA Activator of Human 2 '-5 '-Oligoadenylate Synthetase 1
Volume: 31
04/01/2017 Authors: Calderon BM; Conn GL
Human noncoding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR.
RNA Volume: 23 Page(s): 557 - 566
04/01/2017 Authors: Calderon BM; Conn GL
A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis.
J Biol Chem Volume: 292 Page(s): 1977 - 1987
02/03/2017 Authors: Witek MA; Kuiper EG; Minten E; Crispell EK; Conn GL
Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast.
Genetics Volume: 205 Page(s): 221 - 237
01/01/2017 Authors: Fasken MB; Losh JS; Leung SW; Brutus S; Avin B; Vaught JC; Potter-Birriel J; Craig T; Conn GL; Mills-Lujan K
Use of a Grant Writing Class in Training PhD Students.
Traffic Volume: 17 Page(s): 803 - 814
07/01/2016 Authors: Kahn RA; Conn GL; Pavlath GK; Corbett AH
Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase.
J Biol Chem Volume: 291 Page(s): 3280 - 3290
02/12/2016 Authors: Owings JP; Kuiper EG; Prezioso SM; Meisner J; Varga JJ; Zelinskaya N; Dammer EB; Duong DM; Seyfried NT; Albert S
Functional dichotomy in the 16S rRNA (m1A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization.
Nucleic Acids Res Volume: 44 Page(s): 342 - 353
01/08/2016 Authors: Witek MA; Conn GL
Adenovirus VA RNA: An essential pro-viral non-coding RNA.
Virus Res Volume: 212 Page(s): 39 - 52
01/02/2016 Authors: Vachon VK; Conn GL
Heterologous Expression and Functional Characterization of the Exogenously Acquired Aminoglycoside Resistance Methyltransferases RmtD, RmtD2, and RmtG.
Antimicrob Agents Chemother Volume: 60 Page(s): 699 - 702
01/01/2016 Authors: Corra LL; Witek MA; Zelinskaya N; Pico RC; Conn GL
The Pathogen-Derived Aminoglycoside Resistance 16S rRNA Methyltransferase NpmA Possesses Dual m1A1408/m1G1408 Specificity.
Antimicrob Agents Chemother Volume: 59 Page(s): 7862 - 7865
12/01/2015 Authors: Zelinskaya N; Witek MA; Conn GL
The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs.
J Biol Chem Volume: 290 Page(s): 28156 - 28165
11/20/2015 Authors: Sunita S; Schwartz SL; Conn GL
Functional roles in S-adenosyl-L-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase.
FEBS Lett Volume: 589 Page(s): 3263 - 3270
10/24/2015 Authors: Myers CL; Kuiper EG; Grant PC; Hernandez J; Conn GL; Honek JF
30S Subunit-dependent activation of the Sorangium cellulosum So ce56 aminoglycoside resistance-conferring 16S rRNA methyltransferase Kmr.
Antimicrob Agents Chemother Volume: 59 Page(s): 2807 - 2816
05/01/2015 Authors: Savic M; Sunita S; Zelinskaya N; Desai PM; Macmaster R; Vinal K; Conn GL
Structural Characterization of nc886, a Cellular Non-coding RNA Regulator of the Antiviral Kinase PKR
Volume: 29
04/01/2015 Authors: Calderon B; Conn G
A Formal Scientific Writing Course for Biomedical Graduate Students Enhances Student Training and Success.
Volume: 26
01/01/2015 Authors: Corbett AH; Pavlath GK; Vertino PM; Conn GL; Goldberg JB; Kahn RA
The Pseudomonas aeruginosa EF-Tu modifying enzyme, EftM, is a temperature-regulated enzyme that aids in adhesion and invasion of host cells
Volume: 26
01/01/2015 Authors: Kuiper EG; Owings JP; Prezioso SM; Meisner J; Varga JP; Zelinskaya N; Dammer EB; Duong D; Seyfried N; Alberti S
A novel RNA molecular signature for activation of 2'-5' oligoadenylate synthetase-1.
Nucleic Acids Res Volume: 43 Page(s): 544 - 552
01/01/2015 Authors: Vachon VK; Calderon BM; Conn GL
Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.
Nat Commun Volume: 5 Page(s): 5395
11/07/2014 Authors: Hudson WH; Pickard MR; de Vera IMS; Kuiper EG; Mourtada-Maarabouni M; Conn GL; Kojetin DJ; Williams GT; Ortlund EA
Binding induced RNA conformational changes control substrate recognition and catalysis by the thiostrepton resistance methyltransferase (Tsr).
J Biol Chem Volume: 289 Page(s): 26189 - 26200
09/19/2014 Authors: Kuiper EG; Conn GL
Expansion of the aminoglycoside-resistance 16S rRNA (m(1)A1408) methyltransferase family: expression and functional characterization of four hypothetical enzymes of diverse bacterial origin.
Biochim Biophys Acta Volume: 1844 Page(s): 1648 - 1655
09/01/2014 Authors: Witek MA; Conn GL
Dissection of the adenoviral VA RNAI central domain structure reveals minimum requirements for RNA-mediated inhibition of PKR.
J Biol Chem Volume: 289 Page(s): 23233 - 23245
08/15/2014 Authors: Wilson JL; Vachon VK; Sunita S; Schwartz SL; Conn GL
Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA.
Proc Natl Acad Sci U S A Volume: 111 Page(s): 6275 - 6280
04/29/2014 Authors: Dunkle JA; Vinal K; Desai PM; Zelinskaya N; Savic M; West DM; Conn GL; Dunham CM
The structural basis for recognition and modification of the 30S ribosomal subunit by an antibiotic resistance methyltransferase
Volume: 28
04/01/2014 Authors: Dunkle J; Vinal K; Zelinskaya N; Conn G; Dunham C
Probing the role of active site residues in an antibiotic-resistance methyltransferase
Volume: 28
04/01/2014 Authors: Hernandez J; Kuiper E; Conn G
Insights into the function of the kindlin to ILK interaction from C. elegans
Volume: 24
01/01/2013 Authors: Qadota H; Gernert KM; Luo Y; Subramanian S; Conn GL; Benian GM
Plasmid template design and in vitro transcription of short RNAs within a "structure cassette" for structure probing experiments.
Methods Mol Biol Volume: 941 Page(s): 157 - 169
01/01/2012 Authors: Vachon VK; Conn GL
Cis-acting ribozymes for the production of RNA in vitro transcripts with defined 5' and 3' ends.
Methods Mol Biol Volume: 941 Page(s): 83 - 98
01/01/2012 Authors: Avis JM; Conn GL; Walker SC
General protocols for preparation of plasmid DNA template, RNA in vitro transcription, and RNA purification by denaturing PAGE.
Methods Mol Biol Volume: 941 Page(s): 43 - 58
01/01/2012 Authors: Linpinsel JL; Conn GL
Identification of new inhibitors of protein kinase R guided by statistical modeling.
Bioorg Med Chem Lett Volume: 21 Page(s): 4108 - 4114
07/01/2011 Authors: Bryk R; Wu K; Raimundo BC; Boardman PE; Chao P; Conn GL; Anderson E; Cole JL; Duffy NP; Nathan C
Reduced sweetness of a monellin (MNEI) mutant results from increased protein flexibility and disruption of a distant poly-(L-proline) II helix.
Chem Senses Volume: 36 Page(s): 425 - 434
06/01/2011 Authors: Templeton CM; Ostovar pour S; Hobbs JR; Blanch EW; Munger SD; Conn GL
Structure-function studies of m1A1408 aminoglycoside-resistance ribosomal RNA methyltransferases
Volume: 278 Page(s): 478 - 479
06/01/2011 Authors: Savic M; Macmaster R; Zelinskaya N; Subramanian S; Desai P; Vasiljevic B; Conn GL
Inhibition of PKR by Adenovirus-Associated RNA I
Volume: 100 Page(s): 232 - 233
02/02/2011 Authors: Launer-Felty K; Wong CJ; Wahid AM; Conn GL; Cole JL
Expression, purification and crystallization of adenosine 1408 aminoglycoside-resistance rRNA methyltransferases for structural studies.
Protein Expr Purif Volume: 75 Page(s): 89 - 94
01/01/2011 Authors: Zelinskaya N; Rankin CR; Macmaster R; Savic M; Conn GL
Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria.
Nucleic Acids Res Volume: 38 Page(s): 7791 - 7799
11/01/2010 Authors: Macmaster R; Zelinskaya N; Savic M; Rankin CR; Conn GL
Magnesium-dependent interaction of PKR with adenovirus VAI.
J Mol Biol Volume: 402 Page(s): 638 - 644
10/01/2010 Authors: Launer-Felty K; Wong CJ; Wahid AM; Conn GL; Cole JL
Regulation of PKR By Viral RNAS
Volume: 98 Page(s): 13A - 13A
01/01/2010 Authors: Wong CJ; Heinicke LA; Launer-Felty K; Lary JW; Conn GL; Bevilacqua PC; Cole JL
Heterologous Escherichia coli expression, purification and characterization of the GrmA aminoglycoside-resistance methyltransferase.
Protein J Volume: 28 Page(s): 326 - 332
10/01/2009 Authors: Moric I; Bajkic S; Savic M; Tomic TI; Conn GL; Vasiljevic B
The PKR-binding domain of adenovirus VA RNAI exists as a mixture of two functionally non-equivalent structures.
Nucleic Acids Res Volume: 37 Page(s): 5830 - 5837
09/01/2009 Authors: Wahid AM; Coventry VK; Conn GL
Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics.
Nucleic Acids Res Volume: 37 Page(s): 5420 - 5431
09/01/2009 Authors: Savic M; Lovric J; Tomic TI; Vasiljevic B; Conn GL
Structure of the thiostrepton resistance methyltransferase.S-adenosyl-L-methionine complex and its interaction with ribosomal RNA.
J Biol Chem Volume: 284 Page(s): 17013 - 17020
06/19/2009 Authors: Dunstan MS; Hang PC; Zelinskaya NV; Honek JF; Conn GL
Structure-Function Studies on MNEI: What Makes Monellin Sweet?
Volume: 33 Page(s): S68 - S69
10/01/2008 Authors: Royle C; Hobbs JR; Vigues S; Munger SD; Conn GL
Critical residues for cofactor binding and catalytic activity in the aminoglycoside resistance methyltransferase Sgm.
J Bacteriol Volume: 190 Page(s): 5855 - 5861
09/01/2008 Authors: Savic M; Ilic-Tomic T; Macmaster R; Vasiljevic B; Conn GL
Insights into Class III GPCR function from studies of the T1R taste receptor family
Volume: 22 Page(s): 19 - 19
08/01/2008 Authors: Conn G
Systematic deletion of the adenovirus-associated RNAI terminal stem reveals a surprisingly active RNA inhibitor of double-stranded RNA-activated protein kinase.
J Biol Chem Volume: 283 Page(s): 17485 - 17493
06/20/2008 Authors: Wahid AM; Coventry VK; Conn GL
Analysis of adenovirus VA RNAI structure and stability using compensatory base pair modifications.
Nucleic Acids Res Volume: 36 Page(s): 1645 - 1653
03/01/2008 Authors: Coventry VK; Conn GL
Aminoglycoside resistance genes sgm and kgmB protect bacterial but not yeast small ribosomal subunits in vitro despite high conservation of the rRNA A-site.
Res Microbiol Volume: 159 Page(s): 658 - 662
01/01/2008 Authors: Tomic TI; Moric I; Conn GL; Vasiljevic B
Recombinant RNA expression.
Nat Methods Volume: 4 Page(s): 547 - 548
07/01/2007 Authors: Dunham CM; Conn GL
Monellin (MNEI) at 1.15 A resolution.
Acta Crystallogr Sect F Struct Biol Cryst Commun Volume: 63 Page(s): 162 - 167
03/01/2007 Authors: Hobbs JR; Munger SD; Conn GL
Raman and Raman optical activity (ROA) analysis of RNA structural motifs in Domain I of the EMCV IRES.
Nucleic Acids Res Volume: 35 Page(s): 1169 - 1177
01/01/2007 Authors: Hobro AJ; Rouhi M; Blanch EW; Conn GL
Expression and purification of functional ligand-binding domains of T1R3 taste receptors.
Chem Senses Volume: 31 Page(s): 505 - 513
07/01/2006 Authors: Nie Y; Hobbs JR; Vigues S; Olson WJ; Conn GL; Munger SD
Optimization of a ribosomal structural domain by natural selection.
Biochemistry Volume: 45 Page(s): 6635 - 6643
05/30/2006 Authors: Maeder C; Conn GL; Draper DE
Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli.
Curr Biol Volume: 15 Page(s): 1948 - 1952
11/08/2005 Authors: Nie Y; Vigues S; Hobbs JR; Conn GL; Munger SD
Coevolution of protein and RNA structures within a highly conserved ribosomal domain.
Chem Biol Volume: 12 Page(s): 201 - 206
02/01/2005 Authors: Dunstan MS; Guhathakurta D; Draper DE; Conn GL
Probing the structural basis of sweet taste specificity
Volume: 13 Page(s): 201 - 201
08/01/2004 Authors: Nie Y; Hobbs JR; Vigues S; Conn GL; Munger SD
NMR studies of the structure and Mg2+ binding properties of a conserved RNA motif of EMCV picornavirus IRES element.
Nucleic Acids Res Volume: 32 Page(s): 4715 - 4724
01/01/2004 Authors: Phelan M; Banks RJ; Conn G; Ramesh V
Conserved nucleotides within the J domain of the encephalomyocarditis virus internal ribosome entry site are required for activity and for interaction with eIF4G.
J Virol Volume: 77 Page(s): 12441 - 12449
12/01/2003 Authors: Clark AT; Robertson MEM; Conn GL; Belsham GJ
Expression of active RNA-activated protein kinase (PKR) in bacteria.
Biotechniques Volume: 35 Page(s): 682 - 686
10/01/2003 Authors: Conn GL
General plasmids for producing RNA in vitro transcripts with homogeneous ends.
Nucleic Acids Res Volume: 31 Page(s): e82
08/01/2003 Authors: Walker SC; Avis JM; Conn GL
The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications.
Nucleic Acids Res Volume: 31 Page(s): 2683 - 2693
05/15/2003 Authors: Gyi JI; Gao D; Conn GL; Trent JO; Brown T; Lane AN
A compact RNA tertiary structure contains a buried backbone-K+ complex.
J Mol Biol Volume: 318 Page(s): 963 - 973
05/10/2002 Authors: Conn GL; Gittis AG; Lattman EE; Misra VK; Draper DE
RNA tertiary structure and protein recognition in an L11-RNA complex
Page(s): 105 - 114
01/01/2000 Authors: Draper DE; Conn GL; Gittis AG; GuhaThakurta D; Lattman EE; Reynaldo L
Crystal structure of a conserved ribosomal protein-RNA complex.
Science Volume: 284 Page(s): 1171 - 1174
05/14/1999 Authors: Conn GL; Draper DE; Lattman EE; Gittis AG
The crystal structure of the RNA/DNA hybrid r(GAAGAGAAGC). d(GCTTCTCTTC) shows significant differences to that found in solution.
Nucleic Acids Res Volume: 27 Page(s): 555 - 561
01/15/1999 Authors: Conn GL; Brown T; Leonard GA
A functional ribosomal RNA tertiary structure involves a base triple interaction.
Biochemistry Volume: 37 Page(s): 11980 - 11988
08/25/1998 Authors: Conn GL; Gutell RR; Draper DE
The orientation and dynamics of the C2'-OH and hydration of RNA and DNA.RNA hybrids.
Nucleic Acids Res Volume: 26 Page(s): 3104 - 3110
07/01/1998 Authors: Gyi JI; Lane AN; Conn GL; Brown T
RNA structure.
Curr Opin Struct Biol Volume: 8 Page(s): 278 - 285
06/01/1998 Authors: Conn GL; Draper DE
Energetics of ribosomal protein - RNA recognition
Volume: 74 Page(s): A243 - A243
02/01/1998 Authors: Draper DE; Bukhman YV; Conn GL; Thakurta DG; Reynaldo L
Solution structures of DNA.RNA hybrids with purine-rich and pyrimidine-rich strands: comparison with the homologous DNA and RNA duplexes.
Biochemistry Volume: 37 Page(s): 73 - 80
01/06/1998 Authors: Gyi JI; Lane AN; Conn GL; Brown T
Comparison of the electrophoretic and hydrodynamic properties of DNA and RNA oligonucleotide duplexes.
Biophys J Volume: 73 Page(s): 1532 - 1538
09/01/1997 Authors: Bonifacio GF; Brown T; Conn GL; Lane AN
Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2.
Nucleic Acids Res Volume: 25 Page(s): 2627 - 2634
07/01/1997 Authors: Conte MR; Conn GL; Brown T; Lane AN
Conformational heterogeneity in nucleic acids.
Volume: 213 Page(s): 160 - COMP
04/13/1997 Authors: Lane AN; Gyi JI; Brown T; Conn GL
The dependence of DNase I activity on the conformation of oligodeoxynucleotides.
Biochem J Volume: 321 ( Pt 2) Page(s): 481 - 486
01/15/1997 Authors: Sutton DH; Conn GL; Brown T; Lane AN
Hydration of the RNA duplex r(CGCAAAUUUGCG)2 determined by NMR.
Nucleic Acids Res Volume: 24 Page(s): 3693 - 3699
10/01/1996 Authors: Conte MR; Conn GL; Brown T; Lane AN
Comparison of the thermodynamic stabilities and solution conformations of DNA.RNA hybrids containing purine-rich and pyrimidine-rich strands with DNA and RNA duplexes.
Biochemistry Volume: 35 Page(s): 12538 - 12548
09/24/1996 Authors: Gyi JI; Conn GL; Lane AN; Brown T

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Graeme Conn PhD

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