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Profile

Gary Bassell PhD

  • Department of Cell Biology
    Professor
  • (404) 727-3772
  • gary.bassell@emory.edu
  • Lab Website
  • Pubmed
  • My NCBI
Head shot of Gary Bassell

Overview

Additional Websites
http://cellbio.emory.edu/basselllab/
Research Focus
The research interests of our laboratory are to understand the diverse and critical roles played by mRNA binding proteins and associated factors in the posttranscriptional regulation of gene expression in the nervous system, and investigate how these processes go awry in neurodevelopmental and neurodegenerative disorders. We investigate the normal mechanism, function and regulation of mRNA binding proteins in mRNA transport and local protein synthesis needed for neuronal development and synaptic plasticity. We investigate pathomechanisms for Fragile X syndrome (FXS) and other autism spectrum disorders, as well as two motor neuron diseases: spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). We are using mouse models of neurological diseases to assess the function of mRNA regulation and local protein synthesis in axon guidance, synapse development and neuronal signaling. Efforts are also underway to evaluate different therapeutic modalities in these mouse models of neurological diseases. Our research utilizes an integrated multi-disciplinary approach that involves cellular, molecular, biochemical, physiological, and behavioral methods and paradigms. These studies are expected to reveal new mechanisms important for neuronal development and function, and targeted approaches for therapeutic intervention that treat underlying molecular defects in SMA, Fragile X syndrome and autism spectrum disorders.

Lab Personnel:

GiaLinh "Linda" Nguyen (Lab Manager)
Anwesha Banerjee (Assistant Scientist)
Liang Shi (Assistant Scientist)
Ryan Purcell (Postdoc)
Nisha Raj (Postdoc)
Zachary McEachin (Postdoc)
Aleksandra Janusz-Kaminska (Postdoc)
Pernille Buelow (Graduate Student)
Luke Knudson (Graduate Student)
Kamyra Edokpolor (Graduate Student)
Kun Lin (Graduate Student)

Academic Appointment

  • Charles Howard Candler Professor of Cell Biology and Department Chair, Department of Cell Biology, Emory University School of Medicine
  • Charles Howard Candler Professor of Cell Biology and Department Chair, Departments of Cell Biology (primary) and Neurology (secondary), Emory University School of Medicine

Education

Degrees

  • PhD from University of Massachusetts Medical School
  • BS from Framingham State University

Research

Focus

  • Mechanisms, regulation and function of mRNA transport and local protein synthesis in neurons; Dysfunction of mRNA regulation in fragile X syndrome and spinal muscular atrophy; Development of new drugs for Fragile X and autism therapeutics.

Publications

  • Where to start? Activity-dependent alternative translation initiation generates multifunctional proteoforms in the brain.
    Mol Cell Volume: 84 Page(s): 3863 - 3865
    10/17/2024 Authors: Kosti A; Bassell GJ
  • Isoform balance of the long noncoding RNA NEAT1 is regulated by the RNA-binding protein QKI, governs the glioma transcriptome, and impacts cell migration.
    J Biol Chem Volume: 300 Page(s): 107595
    08/01/2024 Authors: Zakutansky PM; Ku L; Zhang G; Shi L; Li Y; Yao B; Bassell GJ; Read RD; Feng Y
  • Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner.
    Mol Biol Cell Volume: 35 Page(s): ar43
    03/01/2024 Authors: Janusz-Kaminska A; Brzozowska A; Tempes A; Urbanska M; Blazejczyk M; Miek J; Kuzniewska B; Zeng J; Wesawski J; Kisielewska K
  • Cryptic exon inclusion is a molecular signature ofLATE-NCin aging brains.
    Acta Neuropathol Volume: 147 Page(s): 29
    02/03/2024 Authors: Chung M; Carter EK; Veire AM; Dammer EB; Chang J; Duong DM; Raj N; Bassell GJ; Glass JD; Gendron TF
  • Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
    Nat Commun Volume: 14 Page(s): 8043
    12/19/2023 Authors: Urzi A; Lahmann I; Nguyen LVN; Rost BR; Garca-Prez A; Lelievre N; Merritt-Garza ME; Phan HC; Bassell GJ; Rossoll W
  • LSD1/KDM1A is essential for neural stem cell differentiation in mice.
    bioRxiv
    12/03/2023 Authors: Falkenberry EC; Reeves M; Scott A; Myrick DA; Fallini C; Bassell GJ; Katz DJ
  • Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.
    Sci Adv Volume: 9 Page(s): eadh0558
    08/18/2023 Authors: Purcell RH; Sefik E; Werner E; King AT; Mosley TJ; Merritt-Garza ME; Chopra P; McEachin ZT; Karne S; Raj N
  • FMRP phosphorylation and interactions with Cdh1 regulate association with dendritic RNA granules and MEF2-triggered synapse elimination.
    Neurobiol Dis Volume: 182 Page(s): 106136
    06/15/2023 Authors: Wilkerson JR; Ifrim MF; Valdez-Sinon AN; Hahn P; Bowles JE; Molinaro G; Janusz-Kaminska A; Bassell GJ; Huber KM
  • Muscleblind-like proteins use modular domains to localize RNAs by riding kinesins and docking to membranes.
    Nat Commun Volume: 14 Page(s): 3427
    06/09/2023 Authors: Hildebrandt RP; Moss KR; Janusz-Kaminska A; Knudson LA; Denes LT; Saxena T; Boggupalli DP; Li Z; Lin K; Bassell GJ
  • Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.
    bioRxiv
    05/26/2023 Authors: Purcell RH; Sefik E; Werner E; King AT; Mosley TJ; Merritt-Garza ME; Chopra P; McEachin ZT; Karne S; Raj N
  • Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2-dependent ISR in C9ORF72 FTD/ALS.
    Elife Volume: 12
    04/19/2023 Authors: Parameswaran J; Zhang N; Braems E; Tilahun K; Pant DC; Yin K; Asress S; Heeren K; Banerjee A; Davis E
  • Muscleblind-like proteins use modular domains to localize RNAs by riding kinesins and docking to membranes
    Volume: 34 Page(s): 186 - 186
    02/01/2023 Authors: Wang E; Bassell G
  • The Fragile X Messenger Ribonucleoprotein (FMRP) Negatively Regulates Clathrin-associated Adaptor Complex Protein 2 (AP2) and Endocytosis
    Volume: 34 Page(s): 1043 - 1044
    02/01/2023 Authors: Shi L; Valdez-Sinon A; Raj N; Kosti A; Faundez V; Bassell G
  • Development of single-molecule ubiquitination mediated fluorescence complementation to visualize protein ubiquitination dynamics in dendrites.
    Cell Rep Volume: 41 Page(s): 111658
    11/15/2022 Authors: Ifrim MF; Janusz-Kaminska A; Bassell GJ
  • ALS-linked KIF5A Exon27 mutant causes neuronal toxicity through gain-of-function.
    EMBO Rep Volume: 23 Page(s): e54234
    08/03/2022 Authors: Pant DC; Parameswaran J; Rao L; Loss I; Chilukuri G; Parlato R; Shi L; Glass JD; Bassell GJ; Koch P
  • Correction to: Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model.
    Neuropsychopharmacology Volume: 47 Page(s): 1733
    08/01/2022 Authors: Gross C; Banerjee A; Tiwari D; Longo F; White AR; Allen AG; Schroeder-Carter LM; Krzeski JC; Elsayed NA; Puckett R
  • Mechanisms Driving the Emergence of Neuronal Hyperexcitability in Fragile X Syndrome.
    Int J Mol Sci Volume: 23
    06/05/2022 Authors: Blow P; Segal M; Bassell GJ
  • Metabolic effects of the schizophrenia-associated 3q29 deletion.
    Transl Psychiatry Volume: 12 Page(s): 66
    02/17/2022 Authors: Pollak RM; Purcell RH; Rutkowski TP; Malone T; Pachura KJ; Bassell GJ; Epstein MP; Dawson PA; Smith MR; Jones DP
  • Diversity on location.
    Elife Volume: 11
    02/07/2022 Authors: Yoon YJ; Bassell GJ
  • Caregiver Perspectives on a Child's Diagnosis of 3q29 Deletion: "We Can't Just Wish This Thing Away".
    J Dev Behav Pediatr Volume: 43 Page(s): e94 - e102
    02/01/2022 Authors: Glassford MR; Purcell RH; Pass S; Murphy MM; Bassell GJ; Mulle JG; Emory 3q29 Project,*
  • Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy.
    eNeuro Volume: 9
    01/01/2022 Authors: Edokpolor KS; Banerjee A; McEachin ZT; Gu J; Kosti A; Arboleda JD; Garca PS; Wang ET; Bassell GJ
  • A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.
    Nat Neurosci Volume: 24 Page(s): 1377 - 1391
    10/01/2021 Authors: Kang Y; Zhou Y; Li Y; Han Y; Xu J; Niu W; Li Z; Liu S; Feng H; Huang W
  • Remembering Stephen T. Warren, a pillar of neurogenetics (1953-2021).
    Nat Neurosci Volume: 24 Page(s): 1340 - 1341
    10/01/2021 Authors: Jin P; Bassell GJ
  • Craniofacial features of 3q29 deletion syndrome: Application of next-generation phenotyping technology.
    Am J Med Genet A Volume: 185 Page(s): 2094 - 2101
    07/01/2021 Authors: Mak BC; Sanchez Russo R; Gambello MJ; Fleischer N; Black ED; Leslie E; Murphy MM; Emory 3q29 Project; Mulle JG
  • Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome.
    Transl Psychiatry Volume: 11 Page(s): 357
    06/15/2021 Authors: Sefik E; Purcell RH; Emory 3q29 Project; Walker EF; Bassell GJ; Mulle JG
  • The PI3-Kinase p110 Isoform Controls Severity of Cocaine-Induced Sequelae and Alters the Striatal Transcriptome.
    Biol Psychiatry Volume: 89 Page(s): 959 - 969
    05/15/2021 Authors: Shapiro LP; Pitts EG; Li DC; Barbee BR; Hinton EA; Bassell GJ; Gross C; Gourley SL
  • Deep phenotyping in 3q29 deletion syndrome: recommendations for clinical care.
    Genet Med Volume: 23 Page(s): 872 - 880
    05/01/2021 Authors: Sanchez Russo R; Gambello MJ; Murphy MM; Aberizk K; Black E; Burrell TL; Carlock G; Cubells JF; Epstein MT; Espana R
  • FMRP attenuates activity dependent modifications in the mitochondrial proteome.
    Mol Brain Volume: 14 Page(s): 75
    04/30/2021 Authors: Blow P; Zlatic SA; Wenner PA; Bassell GJ; Faundez V
  • Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
    Cell Rep Volume: 35 Page(s): 108991
    04/13/2021 Authors: Raj N; McEachin ZT; Harousseau W; Zhou Y; Zhang F; Merritt-Garza ME; Taliaferro JM; Kalinowska M; Marro SG; Hales CM
  • Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion.
    Mol Psychiatry Volume: 26 Page(s): 772 - 783
    03/01/2021 Authors: Rutkowski TP; Purcell RH; Pollak RM; Grewenow SM; Gafford GM; Malone T; Khan UA; Schroeder JP; Epstein MP; Bassell GJ
  • The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease.
    Neurobiol Dis Volume: 149 Page(s): 105228
    02/01/2021 Authors: Bakkar N; Starr A; Rabichow BE; Lorenzini I; McEachin ZT; Kraft R; Chaung M; Macklin-Isquierdo S; Wingfield T; Carhart B
  • Mitochondrial Structure and Polarity in Dendrites and the Axon Initial Segment Are Regulated by Homeostatic Plasticity and Dysregulated in Fragile X Syndrome.
    Front Cell Dev Biol Volume: 9 Page(s): 702020
    01/01/2021 Authors: Blow P; Wenner PA; Faundez V; Bassell GJ
  • TBK1 interacts with tau and enhances neurodegeneration in tauopathy.
    J Biol Chem Volume: 296 Page(s): 100760
    01/01/2021 Authors: Abreha MH; Ojelade S; Dammer EB; McEachin ZT; Duong DM; Gearing M; Bassell GJ; Lah JJ; Levey AI; Shulman JM
  • Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage.
    Neurobiol Dis Volume: 146 Page(s): 105085
    12/01/2020 Authors: Johnson MA; Deng Q; Taylor G; McEachin ZT; Chan AWS; Root J; Bassell GJ; Kukar T
  • RNA-mediated toxicity in C9orf72 ALS and FTD.
    Neurobiol Dis Volume: 145 Page(s): 105055
    11/01/2020 Authors: McEachin ZT; Parameswaran J; Raj N; Bassell GJ; Jiang J
  • Protocol for Immuno-Enrichment of FLAG-Tagged Protein Complexes.
    STAR Protoc Volume: 1 Page(s): 100083
    09/18/2020 Authors: Valdez-Sinon AN; Gokhale A; Faundez V; Bassell GJ
  • Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.
    Neuron Volume: 107 Page(s): 292 - 305.e6
    07/22/2020 Authors: McEachin ZT; Gendron TF; Raj N; Garca-Murias M; Banerjee A; Purcell RH; Ward PJ; Todd TW; Merritt-Garza ME; Jansen-West K
  • Regulation of RNA granules by FMRP and implications for neurological diseases.
    Traffic Volume: 21 Page(s): 454 - 462
    07/01/2020 Authors: Lai A; Valdez-Sinon AN; Bassell GJ
  • Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns.
    Mol Autism Volume: 11 Page(s): 52
    06/19/2020 Authors: Das Sharma S; Pal R; Reddy BK; Selvaraj BT; Raj N; Samaga KK; Srinivasan DJ; Ornelas L; Sareen D; Livesey MR
  • FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences.
    Elife Volume: 9
    06/08/2020 Authors: Goering R; Hudish LI; Guzman BB; Raj N; Bassell GJ; Russ HA; Dominguez D; Taliaferro JM
  • Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
    iScience Volume: 23 Page(s): 101132
    05/22/2020 Authors: Valdez-Sinon AN; Lai A; Shi L; Lancaster CL; Gokhale A; Faundez V; Bassell GJ
  • Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration InVivo.
    Cell Rep Volume: 31 Page(s): 107616
    05/05/2020 Authors: Todd TW; McEachin ZT; Chew J; Burch AR; Jansen-West K; Tong J; Yue M; Song Y; Castanedes-Casey M; Kurti A
  • Comprehensive phenotyping of neuropsychiatric traits in a multiplex 3q29 deletion family: a case report.
    BMC Psychiatry Volume: 20 Page(s): 184
    04/22/2020 Authors: Murphy MM; Burrell TL; Cubells JF; Epstein MT; Espana R; Gambello MJ; Goines K; Klaiman C; Koh S; Russo RS
  • A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis.
    Nat Neurosci Volume: 23 Page(s): 386 - 397
    03/01/2020 Authors: Rodriguez CM; Wright SE; Kearse MG; Haenfler JM; Flores BN; Liu Y; Ifrim MF; Glineburg MR; Krans A; Jafar-Nejad P
  • Biased modulators of NMDA receptors control channel opening and ion selectivity.
    Nat Chem Biol Volume: 16 Page(s): 188 - 196
    02/01/2020 Authors: Perszyk RE; Swanger SA; Shelley C; Khatri A; Fernandez-Cuervo G; Epplin MP; Zhang J; Le P; Blow P; Garnier-Amblard E
  • CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual.
    Commun Biol Volume: 3 Page(s): 33
    01/20/2020 Authors: Yun Y; Hong S-A; Kim K-K; Baek D; Lee D; Londhe AM; Lee M; Yu J; McEachin ZT; Bassell GJ
  • FUS Recognizes G Quadruplex Structures Within Neuronal mRNAs.
    Front Mol Biosci Volume: 7 Page(s): 6
    01/01/2020 Authors: Imperatore JA; McAninch DS; Valdez-Sinon AN; Bassell GJ; Mihailescu MR
  • METABOLIC DYSFUNCTION AS A CONTRIBUTOR TO PHENOTYPES OF THE SCHIZOPHRENIA-ASSOCIATED 3Q29 DELETION
    Volume: 29 Page(s): S224 - S225
    10/01/2019 Authors: Pollak R; Purcell R; Rutkowski T; Malone T; Pachura K; Bassell GJ; Epstein MP; Caspary T; Dawson PA; Jones DP
  • WEIGHTED GENE CO-EXPRESSION NETWORK ANALYSIS OF THE HUMAN FRONTAL CORTEX REVEALS NOVEL INSIGHTS INTO THE SCHIZOPHRENIA-ASSOCIATED 3Q29 DELETION SYNDROME
    Volume: 29 Page(s): S195 - S195
    10/01/2019 Authors: Sefik E; Purcell R; Bassell GJ; Walker E; Mulle J
  • Reward-Related Expectations Trigger Dendritic Spine Plasticity in the Mouse Ventrolateral Orbitofrontal Cortex.
    J Neurosci Volume: 39 Page(s): 4595 - 4605
    06/05/2019 Authors: Whyte AJ; Kietzman HW; Swanson AM; Butkovich LM; Barbee BR; Bassell GJ; Gross C; Gourley SL
  • Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons.
    Cell Rep Volume: 26 Page(s): 1378 - 1388.e3
    02/05/2019 Authors: Blow P; Murphy TJ; Bassell GJ; Wenner P
  • Crosstalk of Local Translation and Mitochondria: Powering Plasticity in Axons and Dendrites.
    Neuron Volume: 101 Page(s): 204 - 206
    01/16/2019 Authors: Rossoll W; Bassell GJ
  • FMRP - G-quadruplex mRNA - miR-125a interactions: Implications for miR-125a mediated translation regulation of PSD-95 mRNA.
    PLoS One Volume: 14 Page(s): e0217275
    01/01/2019 Authors: DeMarco B; Stefanovic S; Williams A; Moss KR; Anderson BR; Bassell GJ; Mihailescu MR
  • Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model.
    Neuropsychopharmacology Volume: 44 Page(s): 324 - 333
    01/01/2019 Authors: Gross C; Banerjee A; Tiwari D; Longo F; White AR; Allen AG; Schroeder-Carter LM; Krzeski JC; Elsayed NA; Puckett R
  • Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies.
    Brain Res Volume: 1693 Page(s): 24 - 36
    08/15/2018 Authors: Banerjee A; Ifrim MF; Valdez AN; Raj N; Bassell GJ
  • microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease.
    Front Mol Neurosci Volume: 11 Page(s): 455
    01/01/2018 Authors: Thomas KT; Gross C; Bassell GJ
  • IMPAIRED CONSCIOUSNESS STATES IN MYOTONIC DYSTROPHY-TYPE 1 MEDIATION BY gamma-AMINO BUTYRIC ACID (GABA)
    Volume: 40 Page(s): E285 - E285
    12/01/2017 Authors: McConnell O; Wang E; Bassell G; Moody O; Jenkins A; Freeman A; Trotti LM; Saini P; Rye D
  • Familiarity with a vocal category biases the compartmental expression of Arc/Arg3.1 in core auditory cortex.
    Learn Mem Volume: 24 Page(s): 612 - 621
    12/01/2017 Authors: Ivanova TN; Gross C; Mappus RC; Kwon YJ; Bassell GJ; Liu RC
  • The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice.
    Hum Mol Genet Volume: 26 Page(s): 3663 - 3681
    10/01/2017 Authors: Rha J; Jones SK; Fidler J; Banerjee A; Leung SW; Morris KJ; Wong JC; Inglis GAS; Shapiro L; Deng Q
  • The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons.
    Cell Rep Volume: 20 Page(s): 1372 - 1384
    08/08/2017 Authors: Bienkowski RS; Banerjee A; Rounds JC; Rha J; Omotade OF; Gross C; Morris KJ; Leung SW; Pak C; Jones SK
  • Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5'-UTR.
    Mol Biosyst Volume: 13 Page(s): 1448 - 1457
    07/25/2017 Authors: McAninch DS; Heinaman AM; Lang CN; Moss KR; Bassell GJ; Rita Mihailescu M; Evans TL
  • Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1 Neurodevelopmental Signal Transduction.
    Cell Rep Volume: 20 Page(s): 1 - 12
    07/05/2017 Authors: Thomas KT; Anderson BR; Shah N; Zimmer SE; Hawkins D; Valdez AN; Gu Q; Bassell GJ
  • Spatially and temporally regulating translation via mRNA-binding proteins in cellular and neuronal function.
    FEBS Lett Volume: 591 Page(s): 1508 - 1525
    06/01/2017 Authors: Donlin-Asp PG; Rossoll W; Bassell GJ
  • ZBP1 phosphorylation at serine 181 regulates its dendritic transport and the development of dendritic trees of hippocampal neurons.
    Sci Rep Volume: 7 Page(s): 1876
    05/12/2017 Authors: Urbanska AS; Janusz-Kaminska A; Switon K; Hawthorne AL; Perycz M; Urbanska M; Bassell GJ; Jaworski J
  • Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation.
    J Neurosci Volume: 37 Page(s): 1685 - 1695
    02/15/2017 Authors: Lepelletier L; Langlois SD; Kent CB; Welshhans K; Morin S; Bassell GJ; Yam PT; Charron F
  • The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly.
    Cell Rep Volume: 18 Page(s): 1660 - 1673
    02/14/2017 Authors: Donlin-Asp PG; Fallini C; Campos J; Chou C-C; Merritt ME; Phan HC; Bassell GJ; Rossoll W
  • Muscleblind-like RNA binding proteins form RNA transport granules associated with Kif1b.
    Volume: 28
    01/01/2017 Authors: Bassell GJ; Moss KR; Dences L; Knudson L; Wang ET
  • Dysregulation of mRNA Localization and Translation in Genetic Disease.
    J Neurosci Volume: 36 Page(s): 11418 - 11426
    11/09/2016 Authors: Wang ET; Taliaferro JM; Lee J-A; Sudhakaran IP; Rossoll W; Gross C; Moss KR; Bassell GJ
  • MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset.
    Cell Rep Volume: 17 Page(s): 37 - 45
    09/27/2016 Authors: Gross C; Yao X; Engel T; Tiwari D; Xing L; Rowley S; Danielson SW; Thomas KT; Jimenez-Mateos EM; Schroeder LM
  • Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing protein 1 mRNA 5 '-UTR: a potential link between fragile X syndrome and splicing
    Volume: 252
    08/20/2016 Authors: Heinaman A; McAninch D; Lang C; Williams K; Bassell G; Mihailescu MR; Evans T
  • Identification of consensus binding sites clarifies FMRP binding determinants.
    Nucleic Acids Res Volume: 44 Page(s): 6649 - 6659
    08/19/2016 Authors: Anderson BR; Chopra P; Suhl JA; Warren ST; Bassell GJ
  • Trehalose enhances progranulin expression in progranulin-deficient patient cells and mouse brain
    Volume: 138 Page(s): 249 - 249
    08/01/2016 Authors: Holler C; Taylor G; McEachin Z; Deng Q; Watkins W; Hudson K; Easley C; Hu W; Hales C; Rossoll W
  • A role for the survival of motor neuron protein in mRNP assembly and transport.
    Curr Opin Neurobiol Volume: 39 Page(s): 53 - 61
    08/01/2016 Authors: Donlin-Asp PG; Bassell GJ; Rossoll W
  • Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
    Mol Neurodegener Volume: 11 Page(s): 46
    06/24/2016 Authors: Holler CJ; Taylor G; McEachin ZT; Deng Q; Watkins WJ; Hudson K; Easley CA; Hu WT; Hales CM; Rossoll W
  • Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons.
    J Neurosci Volume: 36 Page(s): 3811 - 3820
    03/30/2016 Authors: Fallini C; Donlin-Asp PG; Rouanet JP; Bassell GJ; Rossoll W
  • hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation.
    Mol Biol Cell Volume: 27 Page(s): 518 - 534
    02/01/2016 Authors: Williams KR; McAninch DS; Stefanovic S; Xing L; Allen M; Li W; Feng Y; Mihailescu MR; Bassell GJ
  • Increased expression of the PI3K catalytic subunit p110 underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family.
    Mol Autism Volume: 7 Page(s): 3
    01/01/2016 Authors: Poopal AC; Schroeder LM; Horn PS; Bassell GJ; Gross C
  • Fragile X mental retardation protein interactions with a G quadruplex structure in the 3'-untranslated region of NR2B mRNA.
    Mol Biosyst Volume: 11 Page(s): 3222 - 3230
    12/01/2015 Authors: Stefanovic S; DeMarco BA; Underwood A; Williams KR; Bassell GJ; Mihailescu MR
  • A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR.
    Proc Natl Acad Sci U S A Volume: 112 Page(s): E6553 - E6561
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    J Neurosci Volume: 35 Page(s): 7116 - 7130
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  • Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.
    Cell Rep Volume: 11 Page(s): 727 - 736
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    Cell Rep Volume: 11 Page(s): 681 - 688
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    01/01/2015 Authors: Stefanovic S; Bassell GJ; Mihailescu MR
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    Volume: 26
    01/01/2015 Authors: Donlin-Asp PG; Ruppersburg CC; Hartzell C; Bassell G
  • The RNA Binding Protein, ZC3H14, Localizes to Nuclear Speckles and Neuronal Axons to Coordinate Multiple Steps in Gene Expression that are Required for Proper Brain Function
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    01/01/2015 Authors: Rha J; Leung SW; Morris KJ; Shi Y; Dammer EB; Kelly SM; Moberg KH; Gross C; Bassell G; Corbett AH
  • A new step in ciliogenesis: The ANO1 Nimbus.
    Volume: 25
    12/01/2014 Authors: Ruppersburg CC; Donlin-Asp PG; Bassell GJ; Hartzell C
  • SMN functions as a chaperone for mRNP complex assembly.
    Volume: 25
    12/01/2014 Authors: Donlin-Asp PG; Fallini C; Rouanet JP; Williams KR; Bassell GJ; Rossoll W
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    Hum Mol Genet Volume: 23 Page(s): 5479 - 5491
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    Dev Neurobiol Volume: 74 Page(s): 319 - 332
    03/01/2014 Authors: Fallini C; Rouanet JP; Donlin-Asp PG; Guo P; Zhang H; Singer RH; Rossoll W; Bassell GJ
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    Dev Neurobiol Volume: 74 Page(s): 397 - 406
    03/01/2014 Authors: Sasaki Y; Gross C; Xing L; Goshima Y; Bassell GJ
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    Front Mol Neurosci Volume: 7 Page(s): 12
    01/01/2014 Authors: Gross C; Bassell GJ
  • Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions.
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    Neuron Volume: 80 Page(s): 72 - 79
    10/02/2013 Authors: Jakkamsetti V; Tsai N-P; Gross C; Molinaro G; Collins KA; Nicoletti F; Wang KH; Osten P; Bassell GJ; Gibson JR
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    05/15/2013 Authors: Swanger SA; He YA; Richter JD; Bassell GJ
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    01/01/2013 Authors: Larimore J; Ryder PV; Kim K-Y; Ambrose LA; Chapleau C; Calfa G; Gross C; Bassell GJ; Pozzo-Miller L; Smith Y
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    J Neurosci Volume: 32 Page(s): 15133 - 15141
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    Hum Mol Genet Volume: 21 Page(s): 3703 - 3718
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    05/09/2012 Authors: Gross C; Bassell GJ
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    04/01/2012 Authors: Tyor W; Fritz-French C; Welshhans K; Zhang L; Sas A; Bassell G
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    Mol Biol Cell Volume: 23 Page(s): 1500 - 1509
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    PLoS One Volume: 7 Page(s): e38658
    01/01/2012 Authors: Dammer EB; Fallini C; Gozal YM; Duong DM; Rossoll W; Xu P; Lah JJ; Levey AI; Peng J; Bassell GJ
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    Neuropsychopharmacology Volume: 37 Page(s): 178 - 195
    01/01/2012 Authors: Gross C; Berry-Kravis EM; Bassell GJ
  • Examining the Role for the Survival of Motor Neuron Protein in Axonal mRNA Localization and Transport in Spinal Motor Neurons.
    MOLECULAR BIOLOGY OF THE CELL Volume: 23
    01/01/2012 Authors: Fallini C; Donlin-Asp PG; Bassell G; Rossoll W
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    11/23/2011 Authors: Bassell GJ
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    Mol Brain Volume: 4 Page(s): 40
    11/03/2011 Authors: Han L; Wen Z; Lynn RC; Baudet M-L; Holt CE; Sasaki Y; Bassell GJ; Zheng JQ
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    06/10/2011 Authors: Muddashetty RS; Nalavadi VC; Gross C; Yao X; Xing L; Laur O; Warren ST; Bassell GJ
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    05/01/2011 Authors: Bassell GJ
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    05/01/2011 Authors: Peter CJ; Evans M; Thayanithy V; Taniguchi-Ishigaki N; Bach I; Kolpak A; Bassell GJ; Rossoll W; Lorson CL; Bao Z-Z
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    04/13/2011 Authors: Gross C; Yao X; Pong DL; Jeromin A; Bassell GJ
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    01/01/2011 Authors: Xing L; Yao X; Williams KR; Bassell GJ
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    01/01/2011 Authors: Sasaki Y; Xing L; Gross C; Goshima Y; Bassell GJ
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    08/11/2010 Authors: Gross C; Nakamoto M; Yao X; Chan C-B; Yim SY; Ye K; Warren ST; Bassell GJ
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    Mol Neurodegener Volume: 5 Page(s): 17
    04/21/2010 Authors: Fallini C; Bassell GJ; Rossoll W
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    03/18/2009 Authors: Muddashetty R; Bassell GJ
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    01/01/2001 Authors: Bassell GJ; Singer RH
  • Trafficking of zip code binding protein and binding to the beta-actin zip code mediate the regulation of beta-actin mRNA localization to neuronal processes.
    MOLECULAR BIOLOGY OF THE CELL Volume: 11 Page(s): 156A - 156A
    12/01/2000 Authors: Eom T; Zhang HL; Oleynikov YS; Shenoy SM; Singer RH; Bassell GJ
  • ZBP2, a predominantly nuclear protein, is involved in the cytoplasmic localization of beta-actin mRNA in chicken embryo fibroblasts and neurons
    MOLECULAR BIOLOGY OF THE CELL Volume: 11 Page(s): 156A - 156A
    12/01/2000 Authors: Pan F; Gu W; Zhang HL; Bassell G; Singer RH
  • Targeting of CaMKIIa mRNA and polyribosomes to dendrites and spines or hippocampal neurons is stimulated by BDNF and NT-3
    EUROPEAN JOURNAL OF NEUROSCIENCE Volume: 12 Page(s): 2 - 2
    01/01/2000 Authors: Bassell GJ; Martinez MM; Schubert AL; Plociniak MP; Zhang HL; Shenoy SM; Singer RH
  • Neurotrophin regulation of beta-actin mRNA and protein localization within growth cones
    MOLECULAR BIOLOGY OF THE CELL Volume: 10 Page(s): 8A - 8A
    11/01/1999 Authors: Zhang H; Singer RH; Bassell GJ
  • Neuronal zip code binding proteins (ZBP) for beta-actin mRNA localization to growth cones
    MOLECULAR BIOLOGY OF THE CELL Volume: 10 Page(s): 177A - 177A
    11/01/1999 Authors: Eom T; Zhang HL; Oleynikov Y; Singer RH; Bassell GJ
  • Neurotrophin regulation of beta-actin mRNA and protein localization within growth cones.
    J Cell Biol Volume: 147 Page(s): 59 - 70
    10/04/1999 Authors: Zhang HL; Singer RH; Bassell GJ
  • The travels of mRNAs through all cells large and small.
    FASEB J Volume: 13 Page(s): 447 - 454
    03/01/1999 Authors: Bassell GJ; Oleynikov Y; Singer RH
  • Involvement of 3 ' UTR sequences and RNA binding proteins in beta-actin protein localization to growth cones.
    MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 189A - 189A
    11/01/1998 Authors: Zhang HL; Oleynikov Y; Singer RH; Bassell GJ
  • Identification of ZBP2, a 95 kDa protein involved in beta-actin mRNA localization
    MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 189A - 189A
    11/01/1998 Authors: Gu W; Pan F; Zhang H; Bassell G; Singer RH
  • Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types.
    Brain Res Volume: 804 Page(s): 177 - 192
    09/07/1998 Authors: Ikezu T; Ueda H; Trapp BD; Nishiyama K; Sha JF; Volonte D; Galbiati F; Byrd AL; Bassell G; Serizawa H
  • Sorting of beta-actin mRNA and protein to neurites and growth cones in culture.
    J Neurosci Volume: 18 Page(s): 251 - 265
    01/01/1998 Authors: Bassell GJ; Zhang H; Byrd AL; Femino AM; Singer RH; Taneja KL; Lifshitz LM; Herman IM; Kosik KS
  • Sorting of mRNAs in dendrites and axons of cultured neurons visualized using high resolution in situ hybridization: Implications for neuronal polarity and process outgrowth
    Page(s): 431 - 432
    01/01/1998 Authors: Zhang HL; Byrd AL; Singer RH; Bassell GJ
  • Signal transduction mechanisms can promote the transport of beta-actin mRNA to neuronal growth cones and localization of beta-actin protein
    MOLECULAR BIOLOGY OF THE CELL Volume: 8 Page(s): 1239 - 1239
    11/01/1997 Authors: Zhang HL; Byrd AL; Shi L; Singer RH; Bassell GJ
  • mRNA and cytoskeletal filaments.
    Curr Opin Cell Biol Volume: 9 Page(s): 109 - 115
    02/01/1997 Authors: Bassell G; Singer RH
  • Translocation of RNA granules in living neurons.
    J Neurosci Volume: 16 Page(s): 7812 - 7820
    12/15/1996 Authors: Knowles RB; Sabry JH; Martone ME; Deerinck TJ; Ellisman MH; Bassell GJ; Kosik KS
  • LOCALIZATION OF BETA-ACTIN MESSENGER-RNA TO GROWTH CONES DEPENDS ON MICROTUBLES AND CIS-ACTING SEQUENCES SPECIFIC TO NEURONS
    MOLECULAR BIOLOGY OF THE CELL Volume: 6 Page(s): 700 - 700
    11/01/1995 Authors: BASSELL GJ; KAO AC; KISLAUSKIS EH; FEMINO AF; LIFSHITZ LM; SINGER RH; KOSIK KS
  • Localization of HIV RNA in mitochondria of infected cells: potential role in cytopathogenicity.
    J Cell Biol Volume: 126 Page(s): 1353 - 1360
    09/01/1994 Authors: Somasundaran M; Zapp ML; Beattie LK; Pang L; Byron KS; Bassell GJ; Sullivan JL; Singer RH
  • Single mRNAs visualized by ultrastructural in situ hybridization are principally localized at actin filament intersections in fibroblasts.
    J Cell Biol Volume: 126 Page(s): 863 - 876
    08/01/1994 Authors: Bassell GJ; Powers CM; Taneja KL; Singer RH
  • Association of poly(A) mRNA with microtubules in cultured neurons.
    Neuron Volume: 12 Page(s): 571 - 582
    03/01/1994 Authors: Bassell GJ; Singer RH; Kosik KS
  • Actin filaments and the spatial positioning of mRNAS.
    Adv Exp Med Biol Volume: 358 Page(s): 183 - 189
    01/01/1994 Authors: Bassell GJ; Taneja KL; Kislauskis EH; Sundell CL; Powers CM; Ross A; Singer RH
  • High resolution distribution of mRNA within the cytoskeleton.
    J Cell Biochem Volume: 52 Page(s): 127 - 133
    06/01/1993 Authors: Bassell GJ
  • INTRACELLULAR-DISTRIBUTION OF HIV-1 RNA - POSSIBLE CORRELATION WITH CYTOPATHICITY
    MOLECULAR BIOLOGY OF THE CELL Volume: 3 Page(s): A186 - A186
    09/01/1992 Authors: SOMASUNDARAN M; BEATTIE L; BASSELL G; POWERS C; BYRON K; SULLIVAN J; SINGER R
  • ULTRASTRUCTURAL ORGANIZATION OF MESSENGER-RNA ON THE FIBROBLAST CYTOSKELETON
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY Volume: 39 Page(s): 720 - 720
    05/01/1991 Authors: BASSELL G; SINGER R
  • CONSISTENT PRESENCE OF VIRUS AND IMMUNE-SYSTEM MARKERS IN ALZHEIMERS-DISEASE
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY Volume: 35 Page(s): 901 - 901
    09/01/1987 Authors: ROGERS J; SINGER R; BASSELL GJ; LUBERNAROD J
  • Separation and analysis of fluorescent derivatives of myo-inositol and myo-inositol 2-phosphate by high-performance liquid chromatography.
    J Chromatogr Volume: 393 Page(s): 454 - 458
    05/01/1987 Authors: Kargacin ME; Bassell G; Ryan PJ; Honeyman TW
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