Gary Bassell PhD
- Department of Cell Biology
Professor
- (404) 727-3772
- gary.bassell@emory.edu
- Lab Website
- Pubmed
- My NCBI
Overview
Additional Websites
http://cellbio.emory.edu/basselllab/
Research Focus
The research interests of our laboratory are to understand the diverse and critical roles played by mRNA binding proteins and associated factors in the posttranscriptional regulation of gene expression in the nervous system, and investigate how these processes go awry in neurodevelopmental and neurodegenerative disorders. We investigate the normal mechanism, function and regulation of mRNA binding proteins in mRNA transport and local protein synthesis needed for neuronal development and synaptic plasticity. We investigate pathomechanisms for Fragile X syndrome (FXS) and other autism spectrum disorders, as well as two motor neuron diseases: spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). We are using mouse models of neurological diseases to assess the function of mRNA regulation and local protein synthesis in axon guidance, synapse development and neuronal signaling. Efforts are also underway to evaluate different therapeutic modalities in these mouse models of neurological diseases. Our research utilizes an integrated multi-disciplinary approach that involves cellular, molecular, biochemical, physiological, and behavioral methods and paradigms. These studies are expected to reveal new mechanisms important for neuronal development and function, and targeted approaches for therapeutic intervention that treat underlying molecular defects in SMA, Fragile X syndrome and autism spectrum disorders.
Lab Personnel:
GiaLinh "Linda" Nguyen (Lab Manager)
Anwesha Banerjee (Assistant Scientist)
Liang Shi (Assistant Scientist)
Ryan Purcell (Postdoc)
Nisha Raj (Postdoc)
Zachary McEachin (Postdoc)
Aleksandra Janusz-Kaminska (Postdoc)
Pernille Buelow (Graduate Student)
Luke Knudson (Graduate Student)
Kamyra Edokpolor (Graduate Student)
Kun Lin (Graduate Student)
Academic Appointment
- Charles Howard Candler Professor of Cell Biology and Department Chair, Department of Cell Biology, Emory University School of Medicine
- Charles Howard Candler Professor of Cell Biology and Department Chair, Departments of Cell Biology (primary) and Neurology (secondary), Emory University School of Medicine
Education
Degrees
- PhD from University of Massachusetts Medical School
- BS from Framingham State University
Research
Focus
- Mechanisms, regulation and function of mRNA transport and local protein synthesis in neurons; Dysfunction of mRNA regulation in fragile X syndrome and spinal muscular atrophy; Development of new drugs for Fragile X and autism therapeutics.
Publications
-
Where to start? Activity-dependent alternative translation initiation generates multifunctional proteoforms in the brain.
Mol Cell Volume: 84 Page(s): 3863 - 3865
10/17/2024 Authors: Kosti A; Bassell GJ -
Isoform balance of the long noncoding RNA NEAT1 is regulated by the RNA-binding protein QKI, governs the glioma transcriptome, and impacts cell migration.
J Biol Chem Volume: 300 Page(s): 107595
08/01/2024 Authors: Zakutansky PM; Ku L; Zhang G; Shi L; Li Y; Yao B; Bassell GJ; Read RD; Feng Y -
Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner.
Mol Biol Cell Volume: 35 Page(s): ar43
03/01/2024 Authors: Janusz-Kaminska A; Brzozowska A; Tempes A; Urbanska M; Blazejczyk M; Miek J; Kuzniewska B; Zeng J; Wesawski J; Kisielewska K -
Cryptic exon inclusion is a molecular signature ofLATE-NCin aging brains.
Acta Neuropathol Volume: 147 Page(s): 29
02/03/2024 Authors: Chung M; Carter EK; Veire AM; Dammer EB; Chang J; Duong DM; Raj N; Bassell GJ; Glass JD; Gendron TF -
Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Nat Commun Volume: 14 Page(s): 8043
12/19/2023 Authors: Urzi A; Lahmann I; Nguyen LVN; Rost BR; Garca-Prez A; Lelievre N; Merritt-Garza ME; Phan HC; Bassell GJ; Rossoll W -
LSD1/KDM1A is essential for neural stem cell differentiation in mice.
bioRxiv
12/03/2023 Authors: Falkenberry EC; Reeves M; Scott A; Myrick DA; Fallini C; Bassell GJ; Katz DJ -
Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.
Sci Adv Volume: 9 Page(s): eadh0558
08/18/2023 Authors: Purcell RH; Sefik E; Werner E; King AT; Mosley TJ; Merritt-Garza ME; Chopra P; McEachin ZT; Karne S; Raj N -
FMRP phosphorylation and interactions with Cdh1 regulate association with dendritic RNA granules and MEF2-triggered synapse elimination.
Neurobiol Dis Volume: 182 Page(s): 106136
06/15/2023 Authors: Wilkerson JR; Ifrim MF; Valdez-Sinon AN; Hahn P; Bowles JE; Molinaro G; Janusz-Kaminska A; Bassell GJ; Huber KM -
Muscleblind-like proteins use modular domains to localize RNAs by riding kinesins and docking to membranes.
Nat Commun Volume: 14 Page(s): 3427
06/09/2023 Authors: Hildebrandt RP; Moss KR; Janusz-Kaminska A; Knudson LA; Denes LT; Saxena T; Boggupalli DP; Li Z; Lin K; Bassell GJ -
Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.
bioRxiv
05/26/2023 Authors: Purcell RH; Sefik E; Werner E; King AT; Mosley TJ; Merritt-Garza ME; Chopra P; McEachin ZT; Karne S; Raj N