Francisco Alvarez PhD

Department of Cell Biology
Professor

Academic Appointment

Professor and Vice Chair, Department of Cell Biology, Emory University School of Medicine

Education

Degrees

BSC from Universidad Complutense
PhD from Cajal Institute/ Universidad Complutense

Research

Focus

Development of synaptic interneuronal circuits in the spinal cord ventral horn motor network during the onset of motor behaviors and locomotion and their alteration after injury or during neurodegenerative disease. Techniques used: confocal, two-photon and electron microscopy, in vivo imaging, in vitro electrophysiology, mouse transgenic models

Publications

GABA and Glycine Synaptic Release on Axotomized Motoneuron Cell Bodies Promotes Motor Axon Regeneration.
Eur J Neurosci Volume: 61 Page(s): e70045
03/01/2025 Authors: Wood RL; Calvo PM; McCallum WM; English AW; Alvarez FJ
Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity.
Elife Volume: 13
11/28/2024 Authors: Worthy AE; Anderson JT; Lane AR; Gomez-Perez LJ; Wang AA; Griffith RW; Rivard AF; Bikoff JB; Alvarez FJ
Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity.
bioRxiv
09/17/2024 Authors: Worthy AE; Anderson JT; Lane AR; Gomez-Perez L; Wang AA; Griffith RW; Rivard AF; Bikoff JB; Alvarez FJ
VEGF, but Not BDNF, Prevents the Downregulation of KCC2 Induced by Axotomy in Extraocular Motoneurons.
Int J Mol Sci Volume: 25
09/14/2024 Authors: Capilla-Lpez J; Hernndez RG; Carrero-Rojas G; Calvo PM; Alvarez FJ; de la Cruz RR; Pastor AM
Synaptic imbalance and increased inhibition impair motor function in SMA.
bioRxiv
09/01/2024 Authors: Fletcher EV; Chalif JI; Rotterman TM; Pagiazitis JG; Alstyne MV; Sivakumar N; Rabinowitz JE; Pellizzoni L; Alvarez FJ; Mentis GZ
Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia.
Cell Rep Volume: 43 Page(s): 113776
02/27/2024 Authors: Rotterman TM; Haley-Johnson Z; Pottorf TS; Chopra T; Chang E; Zhang S; McCallum WM; Fisher S; Franklin H; Alvarez M
Air-stepping in the neonatal mouse: a powerful tool for analyzing early stages of rhythmic limb movement development.
J Neurophysiol Volume: 131 Page(s): 321 - 337
02/01/2024 Authors: Mistretta OC; Wood RL; English AW; Alvarez FJ
Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF.
Brain Struct Funct Volume: 228 Page(s): 967 - 984
05/01/2023 Authors: Calvo PM; de la Cruz RR; Pastor AM; Alvarez FJ
Massive Loss of Proprioceptive Ia Synapses in Rat Spinal Motoneurons after Nerve Crush Injuries in the Postnatal Period.
eNeuro Volume: 10
02/01/2023 Authors: Arbat-Plana A; Bolvar S; Navarro X; Udina E; Alvarez FJ
The Role of Microglia in Neuroinflammation of the Spinal Cord after Peripheral Nerve Injury.
Cells Volume: 11
06/30/2022 Authors: Pottorf TS; Rotterman TM; McCallum WM; Haley-Johnson ZA; Alvarez FJ
Genetic targeting of adult Renshaw cells using a Calbindin 1 destabilized Cre allele for intersection with Parvalbumin or Engrailed1.
Sci Rep Volume: 11 Page(s): 19861
10/06/2021 Authors: Lane AR; Cogdell IC; Jessell TM; Bikoff JB; Alvarez FJ
Microglia Dynamics and Interactions with Motoneurons Axotomized After Nerve Injuries Revealed By Two-Photon Imaging.
Sci Rep Volume: 10 Page(s): 8648
05/26/2020 Authors: Rotterman TM; Alvarez FJ
Synaptic Plasticity on Motoneurons After Axotomy: A Necessary Change in Paradigm.
Front Mol Neurosci Volume: 13 Page(s): 68
01/01/2020 Authors: Alvarez FJ; Rotterman TM; Akhter ET; Lane AR; English AW; Cope TC
Sciatic Nerve Cut and Repair Using Fibrin Glue in Adult Mice.
Bio Protoc Volume: 9
09/20/2019 Authors: Akhter ET; Rotterman TM; English AW; Alvarez FJ
Spinal Motor Circuit Synaptic Plasticity after Peripheral Nerve Injury Depends on Microglia Activation and a CCR2 Mechanism.
J Neurosci Volume: 39 Page(s): 3412 - 3433
05/01/2019 Authors: Rotterman TM; Akhter ET; Lane AR; MacPherson KP; Garca VV; Tansey MG; Alvarez FJ
Genetic and pharmacological inactivation of apical Na+-K+-2Cl- cotransporter 1 in choroid plexus epithelial cells reveals the physiological function of the cotransporter.
Am J Physiol Cell Physiol Volume: 316 Page(s): C525 - C544
04/01/2019 Authors: Gregoriades JMC; Madaris A; Alvarez FJ; Alvarez-Leefmans FJ
A motor physiology recurrent topic: simplify assumptions to gain extra insight.
J Physiol Volume: 597 Page(s): 2117 - 2118
04/01/2019 Authors: Alvarez FJ
Removal of the Potassium Chloride Co-Transporter from the Somatodendritic Membrane of Axotomized Motoneurons Is Independent of BDNF/TrkB Signaling But Is Controlled by Neuromuscular Innervation.
eNeuro Volume: 6
01/01/2019 Authors: Akhter ET; Griffith RW; English AW; Alvarez FJ
Spinal Interneurons " La Carte".
Neuron Volume: 100 Page(s): 3 - 6
10/10/2018 Authors: Alvarez FJ
VGLUT1 synapses and P-boutons on regenerating motoneurons after nerve crush.
J Comp Neurol Volume: 525 Page(s): 2876 - 2889
09/01/2017 Authors: Schultz AJ; Rotterman TM; Dwarakanath A; Alvarez FJ
Gephyrin and the regulation of synaptic strength and dynamics at glycinergic inhibitory synapses.
Brain Res Bull Volume: 129 Page(s): 50 - 65
03/01/2017 Authors: Alvarez FJ
Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells.
J Comp Neurol Volume: 524 Page(s): 1892 - 1919
06/15/2016 Authors: Siembab VC; Gomez-Perez L; Rotterman TM; Shneider NA; Alvarez FJ
Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits.
Cell Volume: 165 Page(s): 207 - 219
03/24/2016 Authors: Bikoff JB; Gabitto MI; Rivard AF; Drobac E; Machado TA; Miri A; Brenner-Morton S; Famojure E; Diaz C; Alvarez FJ
V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion.
Neuron Volume: 82 Page(s): 138 - 150
04/02/2014 Authors: Zhang J; Lanuza GM; Britz O; Wang Z; Siembab VC; Zhang Y; Velasquez T; Alvarez FJ; Frank E; Goulding M
Normal distribution of VGLUT1 synapses on spinal motoneuron dendrites and their reorganization after nerve injury.
J Neurosci Volume: 34 Page(s): 3475 - 3492
03/05/2014 Authors: Rotterman TM; Nardelli P; Cope TC; Alvarez FJ
Motor axon synapses on renshaw cells contain higher levels of aspartate than glutamate.
PLoS One Volume: 9 Page(s): e97240
01/01/2014 Authors: Richards DS; Griffith RW; Romer SH; Alvarez FJ
Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model.
J Comp Neurol Volume: 521 Page(s): 1449 - 1469
05/01/2013 Authors: Wootz H; Fitzsimons-Kantamneni E; Larhammar M; Rotterman TM; Enjin A; Patra K; Andr E; Van Zundert B; Kullander K; Alvarez FJ
Principles of interneuron development learned from Renshaw cells and the motoneuron recurrent inhibitory circuit.
Ann N Y Acad Sci Volume: 1279 Page(s): 22 - 31
03/01/2013 Authors: Alvarez FJ; Benito-Gonzalez A; Siembab VC
Early pathogenesis in the adult-onset neurodegenerative disease amyotrophic lateral sclerosis.
J Cell Biochem Volume: 113 Page(s): 3301 - 3312
11/01/2012 Authors: van Zundert B; Izaurieta P; Fritz E; Alvarez FJ
Molecular and functional expression of cation-chloride cotransporters in dorsal root ganglion neurons during postnatal maturation.
J Neurophysiol Volume: 108 Page(s): 834 - 852
08/01/2012 Authors: Mao S; Garzon-Muvdi T; Di Fulvio M; Chen Y; Delpire E; Alvarez FJ; Alvarez-Leefmans FJ
Renshaw cells and Ia inhibitory interneurons are generated at different times from p1 progenitors and differentiate shortly after exiting the cell cycle.
J Neurosci Volume: 32 Page(s): 1156 - 1170
01/25/2012 Authors: Benito-Gonzalez A; Alvarez FJ
Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. I. Loss of VGLUT1/IA synapses on motoneurons.
J Neurophysiol Volume: 106 Page(s): 2450 - 2470
11/01/2011 Authors: Alvarez FJ; Titus-Mitchell HE; Bullinger KL; Kraszpulski M; Nardelli P; Cope TC
Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. II. Loss of functional connectivity with motoneurons.
J Neurophysiol Volume: 106 Page(s): 2471 - 2485
11/01/2011 Authors: Bullinger KL; Nardelli P; Pinter MJ; Alvarez FJ; Cope TC
Properties of a distinct subpopulation of GABAergic commissural interneurons that are part of the locomotor circuitry in the neonatal spinal cord.
J Neurosci Volume: 31 Page(s): 4821 - 4833
03/30/2011 Authors: Wu L; Sonner PM; Titus DJ; Wiesner EP; Alvarez FJ; Ziskind-Conhaim L
Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy.
Neuron Volume: 69 Page(s): 453 - 467
02/10/2011 Authors: Mentis GZ; Blivis D; Liu W; Drobac E; Crowder ME; Kong L; Alvarez FJ; Sumner CJ; O'Donovan MJ
Target selection of proprioceptive and motor axon synapses on neonatal V1-derived Ia inhibitory interneurons and Renshaw cells.
J Comp Neurol Volume: 518 Page(s): 4675 - 4701
12/01/2010 Authors: Siembab VC; Smith CA; Zagoraiou L; Berrocal MC; Mentis GZ; Alvarez FJ
Immunogold electron microscopic evidence of differential regulation of GluN1, GluN2A, and GluN2B, NMDA-type glutamate receptor subunits in rat hippocampal CA1 synapses during benzodiazepine withdrawal.
J Comp Neurol Volume: 518 Page(s): 4311 - 4328
11/01/2010 Authors: Das P; Zerda R; Alvarez FJ; Tietz EI
Permanent reorganization of Ia afferent synapses on motoneurons after peripheral nerve injuries.
Ann N Y Acad Sci Volume: 1198 Page(s): 231 - 241
06/01/2010 Authors: Alvarez FJ; Bullinger KL; Titus HE; Nardelli P; Cope TC
Mechanisms regulating the specificity and strength of muscle afferent inputs in the spinal cord.
Ann N Y Acad Sci Volume: 1198 Page(s): 220 - 230
06/01/2010 Authors: Mentis GZ; Alvarez FJ; Shneider NA; Siembab VC; O'Donovan MJ
Mechanisms of excitation of spinal networks by stimulation of the ventral roots.
Ann N Y Acad Sci Volume: 1198 Page(s): 63 - 71
06/01/2010 Authors: O'Donovan MJ; Bonnot A; Mentis GZ; Chub N; Pujala A; Alvarez FJ
Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival.
Neural Dev Volume: 4 Page(s): 42
12/02/2009 Authors: Shneider NA; Brown MN; Smith CA; Pickel J; Alvarez FJ
Increased AMPA receptor GluR1 subunit incorporation in rat hippocampal CA1 synapses during benzodiazepine withdrawal.
J Comp Neurol Volume: 511 Page(s): 832 - 846
12/20/2008 Authors: Das P; Lilly SM; Zerda R; Gunning WT; Alvarez FJ; Tietz EI
Gamma fusimotor neurons dependence on muscle spindle-derived GDNF
Volume: 64 Page(s): S70 - S70
01/01/2008 Authors: Shneider NA; Brown M; Smith C; Alvarez FJ
Primary afferent synapses on developing and adult Renshaw cells.
J Neurosci Volume: 26 Page(s): 13297 - 13310
12/20/2006 Authors: Mentis GZ; Siembab VC; Zerda R; O'Donovan MJ; Alvarez FJ
Postnatal phenotype and localization of spinal cord V1 derived interneurons.
J Comp Neurol Volume: 493 Page(s): 177 - 192
12/12/2005 Authors: Alvarez FJ; Jonas PC; Sapir T; Hartley R; Berrocal MC; Geiman EJ; Todd AJ; Goulding M
Transynaptic effects of tetanus neurotoxin in the oculomotor system.
Brain Volume: 128 Page(s): 2175 - 2188
09/01/2005 Authors: Gonzlez-Forero D; Morcuende S; Alvarez FJ; de la Cruz RR; Pastor AM
Expression of GABAB receptors in magnocellular neurosecretory cells of male, virgin female and lactating rats.
J Neuroendocrinol Volume: 17 Page(s): 413 - 423
07/01/2005 Authors: Richards DS; Villalba RM; Alvarez FJ; Stern JE
Noncholinergic excitatory actions of motoneurons in the neonatal mammalian spinal cord.
Proc Natl Acad Sci U S A Volume: 102 Page(s): 7344 - 7349
05/17/2005 Authors: Mentis GZ; Alvarez FJ; Bonnot A; Richards DS; Gonzalez-Forero D; Zerda R; O'Donovan MJ
Differential postnatal maturation of GABAA, glycine receptor, and mixed synaptic currents in Renshaw cells and ventral spinal interneurons.
J Neurosci Volume: 25 Page(s): 2010 - 2023
02/23/2005 Authors: Gonzlez-Forero D; Alvarez FJ
Regulation of gephyrin cluster size and inhibitory synaptic currents on Renshaw cells by motor axon excitatory inputs.
J Neurosci Volume: 25 Page(s): 417 - 429
01/12/2005 Authors: Gonzalez-Forero D; Pastor AM; Geiman EJ; Bentez-Temio B; Alvarez FJ
Synaptic and subcellular localization of A-kinase anchoring protein 150 in rat hippocampal CA1 pyramidal cells: Co-localization with excitatory synaptic markers.
Neuroscience Volume: 134 Page(s): 155 - 163
01/01/2005 Authors: Lilly SM; Alvarez FJ; Tietz EI
Changes on the properties of glycine receptors during neuronal development.
Brain Res Brain Res Rev Volume: 47 Page(s): 33 - 45
12/01/2004 Authors: Aguayo LG; van Zundert B; Tapia JC; Carrasco MA; Alvarez FJ
Vesicular glutamate transporters in the spinal cord, with special reference to sensory primary afferent synapses.
J Comp Neurol Volume: 472 Page(s): 257 - 280
05/03/2004 Authors: Alvarez FJ; Villalba RM; Zerda R; Schneider SP
Synaptic structural modification following changes in activity induced by tetanus neurotoxin in cat abducens neurons.
J Comp Neurol Volume: 471 Page(s): 201 - 218
03/29/2004 Authors: Gonzlez-Forero D; Pastor AM; Delgado-Garca JM; de la Cruz RR; Alvarez FJ
Pax6 and engrailed 1 regulate two distinct aspects of renshaw cell development.
J Neurosci Volume: 24 Page(s): 1255 - 1264
02/04/2004 Authors: Sapir T; Geiman EJ; Wang Z; Velasquez T; Mitsui S; Yoshihara Y; Frank E; Alvarez FJ; Goulding M
Developmental-dependent action of microtubule depolymerization on the function and structure of synaptic glycine receptor clusters in spinal neurons.
J Neurophysiol Volume: 91 Page(s): 1036 - 1049
02/01/2004 Authors: van Zundert B; Alvarez FJ; Tapia JC; Yeh HH; Diaz E; Aguayo LG
Functional alterations of cat abducens neurons after peripheral tetanus neurotoxin injection.
J Neurophysiol Volume: 89 Page(s): 1878 - 1890
04/01/2003 Authors: Gonzalez-Forero D; de la Cruz RR; Delgado-Garcia JM; Alvarez FJ; Pastor AM
Correlation between CGRP immunoreactivity and firing activity in cat abducens motoneurons.
J Comp Neurol Volume: 451 Page(s): 201 - 212
09/23/2002 Authors: Gonzlez-Forero D; De La Cruz RR; Delgado-Garca JM; Alvarez FJ; Pastor AM
Influence of afferent synaptic innervation on the discharge variability of cat abducens motoneurones.
J Physiol Volume: 541 Page(s): 283 - 299
05/15/2002 Authors: Gonzlez-Forero D; Alvarez FJ; de la Cruz RR; Delgado-Garca JM; Pastor AM
Characterization of GABAB receptor subunits expression in magnocellular neuroendocrine neurons.
FASEB JOURNAL Volume: 16 Page(s): A839 - A839
03/22/2002 Authors: Richards DS; Villalba R; Alvarez F; Stern JE
Glycine and GABA(A) receptor subunits on Renshaw cells: relationship with presynaptic neurotransmitters and postsynaptic gephyrin clusters.
J Comp Neurol Volume: 444 Page(s): 275 - 289
03/12/2002 Authors: Geiman EJ; Zheng W; Fritschy J-M; Alvarez FJ
Glycine receptors involved in synaptic transmission are selectively regulated by the cytoskeleton in mouse spinal neurons.
J Neurophysiol Volume: 87 Page(s): 640 - 644
01/01/2002 Authors: van Zundert B; Alvarez FJ; Yevenes GE; Crcamo JG; Vera JC; Aguayo LG
GABA-B receptor subunits expression in magnocellular neuroendocrine neurons. An immunohistochemical study
FASEB JOURNAL Volume: 15 Page(s): A811 - A811
03/08/2001 Authors: Richards D; Villalba RM; Alvarez FJ; Stern JE
Immunolocalization of the Na(+)-K(+)-2Cl(-) cotransporter in peripheral nervous tissue of vertebrates.
Neuroscience Volume: 104 Page(s): 569 - 582
01/01/2001 Authors: Alvarez-Leefmans FJ; Len-Olea M; Mendoza-Sotelo J; Alvarez FJ; Antn B; Garduo R
Factors regulating AMPA-type glutamate receptor subunit changes induced by sciatic nerve injury in rats.
J Comp Neurol Volume: 426 Page(s): 229 - 242
10/16/2000 Authors: Alvarez FJ; Fyffe RE; Dewey DE; Haftel VK; Cope TC
Postnatal maturation of gephyrin/glycine receptor clusters on developing Renshaw cells.
J Comp Neurol Volume: 426 Page(s): 130 - 142
10/09/2000 Authors: Geiman EJ; Knox MC; Alvarez FJ
Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord.
J Comp Neurol Volume: 422 Page(s): 464 - 487
07/03/2000 Authors: Alvarez FJ; Villalba RM; Carr PA; Grandes P; Somohano PM
GABA mediates presynaptic inhibition at glycinergic synapses in a rat auditory brainstem nucleus.
J Physiol Volume: 525 Pt 2 Page(s): 447 - 459
06/01/2000 Authors: Lim R; Alvarez FJ; Walmsley B
Ultrastructural localization of monoclonal antiphospholipid antibody binding to rat brain.
Exp Neurol Volume: 163 Page(s): 173 - 179
05/01/2000 Authors: Kent MN; Alvarez FJ; Ng AK; Rote NS
Nociceptors for the 21st century.
Curr Rev Pain Volume: 4 Page(s): 451 - 458
01/01/2000 Authors: Alvarez FJ; Fyffe RE
Glycinergic miniature synaptic currents and receptor cluster sizes differ between spinal cord interneurons.
J Neurophysiol Volume: 82 Page(s): 312 - 319
07/01/1999 Authors: Oleskevich S; Alvarez FJ; Walmsley B
Quantal size is correlated with receptor cluster area at glycinergic synapses in the rat brainstem.
J Physiol Volume: 516 ( Pt 2) Page(s): 505 - 512
04/15/1999 Authors: Lim R; Alvarez FJ; Walmsley B
Distribution of cholinergic contacts on Renshaw cells in the rat spinal cord: a light microscopic study.
J Physiol Volume: 515 ( Pt 3) Page(s): 787 - 797
03/15/1999 Authors: Alvarez FJ; Dewey DE; McMillin P; Fyffe RE
Effects of botulinum neurotoxin type A on the expression of gephyrin in cat abducens motoneurons.
J Comp Neurol Volume: 400 Page(s): 1 - 17
10/12/1998 Authors: Moreno-Lpez B; de la Cruz RR; Pastor AM; Delgado-Garca JM; Alvarez FJ
Calbindin D28k expression in immunohistochemically identified Renshaw cells.
Neuroreport Volume: 9 Page(s): 2657 - 2661
08/03/1998 Authors: Carr PA; Alvarez FJ; Leman EA; Fyffe RE
Distribution of 5-hydroxytryptamine-immunoreactive boutons on alpha-motoneurons in the lumbar spinal cord of adult cats.
J Comp Neurol Volume: 393 Page(s): 69 - 83
03/30/1998 Authors: Alvarez FJ; Pearson JC; Harrington D; Dewey D; Torbeck L; Fyffe RE
Diversity of structure and function at mammalian central synapses.
Trends Neurosci Volume: 21 Page(s): 81 - 88
02/01/1998 Authors: Walmsley B; Alvarez FJ; Fyffe RE
Effect of sciatic nerve transection or TTX application on enzyme activity in rat spinal cord.
Neuroreport Volume: 9 Page(s): 357 - 361
01/26/1998 Authors: Carr PA; Haftel V; Alvarez FJ; Cope TC; Fyffe RE
Metabotropic type I glutamate receptors in the spinal cord.
EUROPEAN JOURNAL OF NEUROSCIENCE Volume: 10 Page(s): 406 - 406
01/01/1998 Authors: Alvarez FJ; Somohano PM
Monoclonal antiphosphatidylserine antibodies react directly with feline and murine central nervous system.
J Rheumatol Volume: 24 Page(s): 1725 - 1733
09/01/1997 Authors: Kent M; Alvarez F; Vogt E; Fyffe R; Ng AK; Rote N
Downregulation of metabotropic glutamate receptor 1a in motoneurons after axotomy.
Neuroreport Volume: 8 Page(s): 1711 - 1716
05/06/1997 Authors: Alvarez FJ; Dewey DE; Carr PA; Cope TC; Fyffe RE
Cell-type specific organization of glycine receptor clusters in the mammalian spinal cord.
J Comp Neurol Volume: 379 Page(s): 150 - 170
03/03/1997 Authors: Alvarez FJ; Dewey DE; Harrington DA; Fyffe RE
Distribution of immunoreactivity for the beta 2 and beta 3 subunits of the GABAA receptor in the mammalian spinal cord.
J Comp Neurol Volume: 365 Page(s): 392 - 412
02/12/1996 Authors: Alvarez FJ; Taylor-Blake B; Fyffe RE; De Blas AL; Light AR
Expression of glycine receptors by identified alpha and gamma motoneurones
Page(s): 421 - 428
01/01/1995 Authors: Fyffe REW; Alvarez FJ; Harrington D; Dewey DE
Presence of calcitonin gene-related peptide in intraepithelial nerve fibers and motor end-plates of the cat esophagus: a light and electron microscopic study.
J Auton Nerv Syst Volume: 49 Page(s): 21 - 31
09/01/1994 Authors: Rodrigo J; Pedrosa JA; Alvarez FJ; Bentura ML; Uttenthal O; Martnez-Murillo R; Polak JM
Ultrastructural morphology, synaptic relationships, and CGRP immunoreactivity of physiologically identified C-fiber terminals in the monkey spinal cord.
J Comp Neurol Volume: 329 Page(s): 472 - 490
03/22/1993 Authors: Alvarez FJ; Kavookjian AM; Light AR
Synaptic interactions between GABA-immunoreactive profiles and the terminals of functionally defined myelinated nociceptors in the monkey and cat spinal cord.
J Neurosci Volume: 12 Page(s): 2901 - 2917
08/01/1992 Authors: Alvarez FJ; Kavookjian AM; Light AR
Sub-populations of smaller diameter trigeminal primary afferent neurons defined by expression of calcitonin gene-related peptide and the cell surface oligosaccharide recognized by monoclonal antibody LA4.
J Neurocytol Volume: 20 Page(s): 716 - 731
09/01/1991 Authors: Alvarez FJ; Morris HR; Priestley JV
Distribution of small-diameter primary afferents containing oligosaccharide residues recognized by monoclonal antibody LA4 in the dorsal horn of the cat.
Brain Res Volume: 524 Page(s): 175 - 179
07/30/1990 Authors: Alvarez FJ; Rodrigo J; Priestley JV
Ultrastructure of somatostatin-immunoreactive nerve terminals in laminae I and II of the rat trigeminal subnucleus caudalis.
Neuroscience Volume: 38 Page(s): 359 - 371
01/01/1990 Authors: Alvarez FJ; Priestley JV
Anatomy of somatostatin-immunoreactive fibres and cell bodies in the rat trigeminal subnucleus caudalis.
Neuroscience Volume: 38 Page(s): 343 - 357
01/01/1990 Authors: Alvarez FJ; Priestley JV
Morphology and distribution of primary afferent fibres expressing alpha-galactose extended oligosaccharides in the spinal cord and brainstem of the rat. Light microscopy.
J Neurocytol Volume: 18 Page(s): 611 - 629
10/01/1989 Authors: Alvarez FJ; Rodrigo J; Jessell TM; Dodd J; Priestley JV
Ultrastructure of primary afferent fibres and terminals expressing alpha-galactose extended oligosaccharides in the spinal cord and brainstem of the rat.
J Neurocytol Volume: 18 Page(s): 631 - 645
10/01/1989 Authors: Alvarez FJ; Rodrigo J; Jessell TM; Dodd J; Priestley JV
Light and electron microscopic study of galanin-immunoreactive nerve fibers in the rat posterior thalamus.
J Comp Neurol Volume: 283 Page(s): 1 - 12
05/01/1989 Authors: Blasco I; Alvarez FJ; Villalba RM; Solano ML; Martnez-Murillo R; Rodrigo J
Localization of C-PON immunoreactivity in the rat main olfactory bulb. Demonstration that the population of neurons containing endogenous C-PON display NADPH-diaphorase activity.
Neuroscience Volume: 33 Page(s): 373 - 382
01/01/1989 Authors: Villalba RM; Rodrigo J; Alvarez FJ; Achaval M; Martinez-Murillo R
Immunocytochemical analysis of calcitonin gene-related peptide and vasoactive intestinal polypeptide in Merkel cells and cutaneous free nerve endings of cats.
Cell Tissue Res Volume: 254 Page(s): 429 - 437
11/01/1988 Authors: Alvarez FJ; Cervantes C; Villalba R; Blasco I; Martnez-Murillo R; Polak JM; Rodrigo J
C-PON containing neurons in the rat striatum are also positive for NADPH-diaphorase activity. A light microscopic study.
Brain Res Volume: 462 Page(s): 359 - 362
10/18/1988 Authors: Villalba RM; Martnez-Murillo R; Blasco I; Alvarez FJ; Rodrigo J
Distribution of enkephalin-immunoreactive nerve fibres and terminals in the region of the nucleus basalis magnocellularis of the rat: a light and electron microscopic study.
J Neurocytol Volume: 17 Page(s): 361 - 376
06/01/1988 Authors: Martnez-Murillo R; Blasco I; Alvarez FJ; Villalba R; Solano ML; Montero-Caballero MI; Rodrigo J
Presence of calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity in intraepidermal free nerve endings of cat skin.
Brain Res Volume: 442 Page(s): 391 - 395
03/01/1988 Authors: Alvarez FJ; Cervantes C; Blasco I; Villalba R; Martinez-Murillo R; Polak JM; Rodrigo J

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Francisco Alvarez PhD

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