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Profile

Felipe Garcia Quiroz

  • Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory
    Assistant Professor
  • felipe.quiroz@emory.edu
  • Lab Website
  • Publications
  • BME Profile

  • Wallace H. Coulter Department of Biomedical Engineering
    1760 Haygood Dr NE
Head shot of Felipe Garcia Quiroz

Overview

My lab engineers self-assembling materials that are genetically-encoded and stimuli-responsive. Using these materials, together with genetic and protein engineering tools, we tackle exciting challenges in nanotechnology, biotechnology and medicine. As curious engineers, our work has led us to dissect the DNA and genomic parts that encode for such material systems and their emergent biophysical properties at the DNA/genome and protein levels. To learn new principles of self-assembly and stimuli-responsiveness, we take a bioinspired approach. We probe and manipulate self-assembly phenomena within cells and tissues. The resulting findings illuminate fundamental aspects of biology and serve as foundation to engineer advanced biomaterials.

Academic Appointment

  • Assistant Professor, Wallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine

Education

Degrees

  • PhD from Duke University

Research

Publications

  • Genetically-Encoded Phase Separation Sensors Enable High-Fidelity Live-Cell Probing of Biomolecular Condensates.
    ACS Sens Volume: 10 Page(s): 1857 - 1869
    03/28/2025 Authors: Avecilla ARC; Thomas J; Quiroz FG
  • Programmability and biomedical utility of intrinsically-disordered protein polymers.
    Adv Drug Deliv Rev Volume: 212 Page(s): 115418
    09/01/2024 Authors: Giraldo-Castao MC; Littlejohn KA; Avecilla ARC; Barrera-Villamizar N; Quiroz FG
  • Genetically-encoded phase separation sensors for intracellular probing of biomolecular condensates.

    08/30/2024 Authors: Regina Chua Avecilla A; Thomas J; Quiroz FG
  • Biocondensates fuel tumor immune evasion.
    Nat Cancer Volume: 4 Page(s): 312 - 314
    03/01/2023 Authors: Kubelick KP; Quiroz FG
  • Dissecting biomolecular condensates across stratified epithelial tissues
    Volume: 32
    01/01/2023 Authors: Quiroz FG
  • Cracking the Skin Barrier: Liquid-Liquid Phase Separation Shines under the Skin.
    JID Innov Volume: 1 Page(s): 100036
    09/01/2021 Authors: Avecilla ARC; Quiroz FG
  • Nanoscopic Dynamics Dictate the Phase Separation Behavior of Intrinsically Disordered Proteins.
    Biomacromolecules Volume: 22 Page(s): 1015 - 1025
    02/08/2021 Authors: Laa K; Quiroz FG; Hunold J; Roberts S; Chilkoti A; Hinderberger D
  • Publisher Correction: Mechanics of a multilayer epithelium instruct tumour architecture and function.
    Nature Volume: 586 Page(s): E9
    10/01/2020 Authors: Fiore VF; Krajnc M; Quiroz FG; Levorse J; Pasolli HA; Shvartsman SY; Fuchs E
  • Mechanics of a multilayer epithelium instruct tumour architecture and function.
    Nature Volume: 585 Page(s): 433 - 439
    09/01/2020 Authors: Fiore VF; Krajnc M; Quiroz FG; Levorse J; Pasolli HA; Shvartsman SY; Fuchs E
  • Liquid-liquid phase separation drives skin barrier formation.
    Science Volume: 367
    03/13/2020 Authors: Quiroz FG; Fiore VF; Levorse J; Polak L; Wong E; Pasolli HA; Fuchs E
  • Intrinsically disordered proteins access a range of hysteretic phase separation behaviors.
    Sci Adv Volume: 5 Page(s): eaax5177
    10/01/2019 Authors: Garcia Quiroz F; Li NK; Roberts S; Weber P; Dzuricky M; Weitzhandler I; Yingling YG; Chilkoti A
  • Sequence Directionality Dramatically Affects LCST Behavior of Elastin-Like Polypeptides.
    Biomacromolecules Volume: 19 Page(s): 2496 - 2505
    07/09/2018 Authors: Li NK; Roberts S; Quiroz FG; Chilkoti A; Yingling YG
  • Micellar Self-Assembly of Recombinant Resilin-/Elastin-Like Block Copolypeptides.
    Biomacromolecules Volume: 18 Page(s): 2419 - 2426
    08/14/2017 Authors: Weitzhandler I; Dzuricky M; Hoffmann I; Garcia Quiroz F; Gradzielski M; Chilkoti A
  • Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers.
    Nat Mater Volume: 14 Page(s): 1164 - 1171
    11/01/2015 Authors: Quiroz FG; Chilkoti A
  • Molecular description of the LCST behavior of an elastin-like polypeptide.
    Biomacromolecules Volume: 15 Page(s): 3522 - 3530
    10/13/2014 Authors: Li NK; Garca Quiroz F; Hall CK; Chilkoti A; Yingling YG
  • Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ.
    Cancer Res Volume: 72 Page(s): 5956 - 5965
    11/15/2012 Authors: Liu W; McDaniel J; Li X; Asai D; Quiroz FG; Schaal J; Park JS; Zalutsky M; Chilkoti A
  • Protein polymer hydrogels by in situ, rapid and reversible self-gelation.
    Biomaterials Volume: 33 Page(s): 5451 - 5458
    07/01/2012 Authors: Asai D; Xu D; Liu W; Garcia Quiroz F; Callahan DJ; Zalutsky MR; Craig SL; Chilkoti A
  • Reinforced Portland cement porous scaffolds for load-bearing bone tissue engineering applications.
    J Biomed Mater Res B Appl Biomater Volume: 100 Page(s): 501 - 507
    02/01/2012 Authors: Higuita-Castro N; Gallego-Perez D; Pelaez-Vargas A; Garca Quiroz F; Posada OM; Lpez LE; Sarassa CA; Agudelo-Florez P; Monteiro FJ; Litsky AS
  • Portland cement for bone tissue engineering: Effects of processing and metakaolin blends.
    J Biomed Mater Res B Appl Biomater Volume: 98 Page(s): 308 - 315
    08/01/2011 Authors: Gallego-Perez D; Higuita-Castro N; Quiroz FG; Posada OM; Lpez LE; Litsky AS; Hansford DJ
  • A highly parallel method for synthesizing DNA repeats enables the discovery of 'smart' protein polymers.
    Nat Mater Volume: 10 Page(s): 141 - 148
    02/01/2011 Authors: Amiram M; Quiroz FG; Callahan DJ; Chilkoti A
  • Recursive directional ligation by plasmid reconstruction allows rapid and seamless cloning of oligomeric genes.
    Biomacromolecules Volume: 11 Page(s): 944 - 952
    04/12/2010 Authors: McDaniel JR; Mackay JA; Quiroz FG; Chilkoti A
  • Housekeeping gene stability influences the quantification of osteogenic markers during stem cell differentiation to the osteogenic lineage.
    Cytotechnology Volume: 62 Page(s): 109 - 120
    04/01/2010 Authors: Quiroz FG; Posada OM; Gallego-Perez D; Higuita-Castro N; Sarassa C; Hansford DJ; Agudelo-Florez P; Lpez LE
  • Amyloid-beta-induced ion flux in artificial lipid bilayers and neuronal cells: resolving a controversy.
    Neurotox Res Volume: 16 Page(s): 1 - 13
    07/01/2009 Authors: Capone R; Quiroz FG; Prangkio P; Saluja I; Sauer AM; Bautista MR; Turner RS; Yang J; Mayer M
  • Description of multipotent bovine cell lines and their potential application as a model for the evaluation of biomaterials
    Volume: 18 Page(s): 1211 - 1215
    01/01/2008 Authors: Garcia F; Zapata NM; Lopez LE; Londono C
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