Publications

• Correction: EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair.
  Oncogene Volume: 44 Page(s): 928 - 930
  04/01/2025 Authors: Koyen AE; Madden MZ; Park D; Minten EV; Kapoor-Vazirani P; Werner E; Pfister NT; Haji-Seyed-Javadi R; Zhang H; Xu J
• Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
  Mol Biol Cell Volume: 36 Page(s): ar33
  03/01/2025 Authors: Lane AR; Scher NE; Bhattacharjee S; Zlatic SA; Roberts AM; Gokhale A; Singleton KS; Duong DM; McKenna M; Liu WL
• Mitochondrially Transcribed dsRNA Mediates Manganese-induced Neuroinflammation.
  bioRxiv
  02/20/2025 Authors: Gokhale A; Mendez-Vazquez H; Sampson MM; Moctezuma FGR; Harbuzariu A; Sing A; Zlatic SA; Roberts AM; Prajapati M; Roberts BR
• Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
  
  11/18/2024 Authors: Lane AR; Scher NE; Bhattacharjee S; Zlatic SA; Roberts AM; Gokhale A; Singleton KS; Duong DM; McKenna M; Liu WL
• Proximity Labeling Proteomics Reveals Kv1.3 Potassium Channel Immune Interactors in Microglia.
  Mol Cell Proteomics Volume: 23 Page(s): 100809
  08/01/2024 Authors: Bowen CA; Nguyen HM; Lin Y; Bagchi P; Natu A; Espinosa-Garcia C; Werner E; Kumari R; Brandelli AD; Kumar P
• Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants.
  Hum Mol Genet Volume: 33 Page(s): 12 - 32
  12/12/2023 Authors: Zlatic SA; Werner E; Surapaneni V; Lee CE; Gokhale A; Singleton K; Duong D; Crocker A; Gentile K; Middleton F
• Systemic Proteome Phenotypes Reveal Defective Metabolic Flexibility in Mecp2 Mutants.
  bioRxiv
  09/01/2023 Authors: Zlatic SA; Werner E; Surapaneni V; Lee CE; Gokhale A; Singleton K; Duong D; Crocker A; Gentile K; Middleton F
• Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.
  Sci Adv Volume: 9 Page(s): eadh0558
  08/18/2023 Authors: Purcell RH; Sefik E; Werner E; King AT; Mosley TJ; Merritt-Garza ME; Chopra P; McEachin ZT; Karne S; Raj N
• Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.
  bioRxiv
  05/26/2023 Authors: Purcell RH; Sefik E; Werner E; King AT; Mosley TJ; Merritt-Garza ME; Chopra P; McEachin ZT; Karne S; Raj N
• APOE expression and secretion are modulated by mitochondrial dysfunction.
  Elife Volume: 12
  05/12/2023 Authors: Wynne ME; Ogunbona O; Lane AR; Gokhale A; Zlatic SA; Xu C; Wen Z; Duong DM; Rayaprolu S; Ivanova A
• The mitochondrial RNA granule modulates manganese-dependent cell toxicity.
  Mol Biol Cell Volume: 33 Page(s): ar108
  10/01/2022 Authors: Werner E; Gokhale A; Ackert M; Xu C; Wen Z; Roberts AM; Roberts BR; Vrailas-Mortimer A; Crocker A; Faundez V
• Sulfur- and phosphorus-standardized metal quantification of biological specimens using inductively coupled plasma mass spectrometry.
  STAR Protoc Volume: 3 Page(s): 101334
  06/17/2022 Authors: Lane A; Gokhale A; Werner E; Roberts A; Freeman A; Roberts B; Faundez V
• Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus.
  J Neurosci Volume: 41 Page(s): 6596 - 6616
  08/04/2021 Authors: Gokhale A; Lee CE; Zlatic SA; Freeman AAH; Shearing N; Hartwig C; Ogunbona O; Bassell JL; Wynne ME; Werner E
• Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content.
  J Neurosci Volume: 41 Page(s): 215 - 233
  01/13/2021 Authors: Hartwig C; Mndez GM; Bhattacharjee S; Vrailas-Mortimer AD; Zlatic SA; Freeman AAH; Gokhale A; Concilli M; Werner E; Sapp Savas C
• Heterogeneous Expression of Nuclear Encoded Mitochondrial Genes Distinguishes Inhibitory and Excitatory Neurons.
  eNeuro Volume: 8
  01/01/2021 Authors: Wynne ME; Lane AR; Singleton KS; Zlatic SA; Gokhale A; Werner E; Duong D; Kwong JQ; Crocker AJ; Faundez V
• EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair.
  Oncogene Volume: 39 Page(s): 4798 - 4813
  06/01/2020 Authors: Koyen AE; Madden MZ; Park D; Minten EV; Kapoor-Vazirani P; Werner E; Pfister NT; Haji-Seyed-Javadi R; Zhang H; Xu J
• Replication stress and FOXM1 drive radiation induced genomic instability and cell transformation.
  PLoS One Volume: 15 Page(s): e0235998
  01/01/2020 Authors: Li Z; Yu DS; Doetsch PW; Werner E
• Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue.
  Sci Rep Volume: 9 Page(s): 12546
  08/29/2019 Authors: Werner E; Alter A; Deng Q; Dammer EB; Wang Y; Yu DS; Duong DM; Seyfried NT; Doetsch PW
• Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior.
  J Neurosci Volume: 39 Page(s): 3561 - 3581
  05/01/2019 Authors: Gokhale A; Hartwig C; Freeman AAH; Bassell JL; Zlatic SA; Sapp Savas C; Vadlamudi T; Abudulai F; Pham TT; Crocker A
• Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer.
  Nucleic Acids Res Volume: 46 Page(s): 4515 - 4532
  05/18/2018 Authors: Limpose KL; Trego KS; Li Z; Leung SW; Sarker AH; Shah JA; Ramalingam SS; Werner EM; Dynan WS; Cooper PK
• Targeting a Novel Function for SAMHD1 in DNA Repair for Radiation Therapy and PARP Inhibition
  Volume: 127 Page(s): S192 - S193
  04/01/2018 Authors: Yu D; Daddacha W; Koyen A; Bastien A; Head P; Dhere V; Nabeta G; Connolly E; Werner E; Madden M
• Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees.
  Cell Syst Volume: 6 Page(s): 368 - 380.e6
  03/28/2018 Authors: Zlatic SA; Vrailas-Mortimer A; Gokhale A; Carey LJ; Scott E; Burch R; McCall MM; Rudin-Rush S; Davis JB; Hartwig C
• A Single Exposure to Low- or High-LET Radiation Induces Persistent Genomic Damage in Mouse Epithelial Cells In Vitro and in Lung Tissue.
  Radiat Res Volume: 188 Page(s): 373 - 380
  10/01/2017 Authors: Werner E; Wang Y; Doetsch PW
• SAMHD1 Promotes DNA End Resection to Facilitate DNA Double-Strand Break Repair by Homologous Recombination
  Volume: 58 Page(s): S84 - S84
  09/01/2017 Authors: Yu DS; Daddacha W; Koyen AE; Bastien AJ; Head PE; Dhere VR; Nabeta GN; Connolly EC; Werner E; Madden MZ
• SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
  Cell Rep Volume: 20 Page(s): 1921 - 1935
  08/22/2017 Authors: Daddacha W; Koyen AE; Bastien AJ; Head PE; Dhere VR; Nabeta GN; Connolly EC; Werner E; Madden MZ; Daly MB
• The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors.
  Elife Volume: 6
  03/29/2017 Authors: Comstra HS; McArthy J; Rudin-Rush S; Hartwig C; Gokhale A; Zlatic SA; Blackburn JB; Werner E; Petris M; D'Souza P
• Replication Stress Induced by the Noncatalytic Function of the NTHL1 Glycosylase Results in the Acquisition of Cancer Phenotypes.
  Volume: 57 Page(s): S69 - S69
  09/01/2016 Authors: Limpose KL; Leung SW; Shah JA; Werner EM; Corbett AH; Doetsch PW
• Quality of care in sickle cell disease: Cross-sectional study and development of a measure for adults reporting on ambulatory and emergency department care.
  Medicine (Baltimore) Volume: 95 Page(s): e4528
  08/01/2016 Authors: Evensen CT; Treadwell MJ; Keller S; Levine R; Hassell KL; Werner EM; Smith WR
• Evaluating biomarkers to model cancer risk post cosmic ray exposure.
  Life Sci Space Res (Amst) Volume: 9 Page(s): 19 - 47
  06/01/2016 Authors: Sridharan DM; Asaithamby A; Blattnig SR; Costes SV; Doetsch PW; Dynan WS; Hahnfeldt P; Hlatky L; Kidane Y; Kronenberg A
• Role of Pro-inflammatory Cytokines in Radiation-Induced Genomic Instability in Human Bronchial Epithelial Cells.
  Radiat Res Volume: 184 Page(s): 621 - 629
  12/01/2015 Authors: Werner E; Wang H; Doetsch PW
• HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells.
  Carcinogenesis Volume: 36 Page(s): 1397 - 1406
  11/01/2015 Authors: Marullo R; Werner E; Zhang H; Chen GZ; Shin DM; Doetsch PW
• Neuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor.
  Hum Mol Genet Volume: 24 Page(s): 5512 - 5523
  10/01/2015 Authors: Gokhale A; Vrailas-Mortimer A; Larimore J; Comstra HS; Zlatic SA; Werner E; Manvich DF; Iuvone PM; Weinshenker D; Faundez V
• Regulation of the NTHL1 Base Excision Repair Glycosylase and Genome Maintenance: Implications in Cancer.
  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS Volume: 56 Page(s): S57 - S57
  08/01/2015 Authors: Limpose KL; Shah JA; Werner EM; Corbett AH; Doetsch PW
• Inactivation of a common OGG1 variant by TNF-alpha in mammalian cells.
  DNA Repair (Amst) Volume: 26 Page(s): 15 - 22
  02/01/2015 Authors: Morreall J; Limpose K; Sheppard C; Kow YW; Werner E; Doetsch PW
• Understanding cancer development processes after HZE-particle exposure: roles of ROS, DNA damage repair and inflammation.
  Radiat Res Volume: 183 Page(s): 1 - 26
  01/01/2015 Authors: Sridharan DM; Asaithamby A; Bailey SM; Costes SV; Doetsch PW; Dynan WS; Kronenberg A; Rithidech KN; Saha J; Snijders AM
• Regulation of Base Excision Repair in Genome Maintenance
  Volume: 55 Page(s): S57 - S57
  09/01/2014 Authors: Limpose K; Werner E; Corbett AH; Doetsch PW
• Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability.
  PLoS One Volume: 9 Page(s): e108234
  01/01/2014 Authors: Werner E; Wang H; Doetsch PW
• Vps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomes.
  Hum Mol Genet Volume: 22 Page(s): 5215 - 5228
  12/20/2013 Authors: Tornieri K; Zlatic SA; Mullin AP; Werner E; Harrison R; L'hernault SW; Faundez V
• Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions.
  PLoS One Volume: 8 Page(s): e81162
  01/01/2013 Authors: Marullo R; Werner E; Degtyareva N; Moore B; Altavilla G; Ramalingam SS; Doetsch PW
• MicroRNA-21 modulates the levels of reactive oxygen species by targeting SOD3 and TNF.
  Cancer Res Volume: 72 Page(s): 4707 - 4713
  09/15/2012 Authors: Zhang X; Ng W-L; Wang P; Tian L; Werner E; Wang H; Doetsch P; Wang Y
• A novel microtubule-modulating agent EM011 inhibits angiogenesis by repressing the HIF-1 axis and disrupting cell polarity and migration.
  Carcinogenesis Volume: 33 Page(s): 1769 - 1781
  09/01/2012 Authors: Karna P; Rida PCG; Turaga RC; Gao J; Gupta M; Fritz A; Werner E; Yates C; Zhou J; Aneja R
• The Role of Reactive Oxygen Species in Cisplatin Cytotoxicity
  Volume: 53 Page(s): S32 - S32
  09/01/2012 Authors: Marullo R; Degtyareva NP; Werner E; Ramalingam SS; Doetsch PW
• Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.
  J Neurosci Volume: 32 Page(s): 3697 - 3711
  03/14/2012 Authors: Gokhale A; Larimore J; Werner E; So L; Moreno-De-Luca A; Lese-Martin C; Lupashin VV; Smith Y; Faundez V
• Tumor endothelial marker 8 amplifies canonical Wnt signaling in blood vessels.
  PLoS One Volume: 6 Page(s): e22334
  01/01/2011 Authors: Verma K; Gu J; Werner E
• Endosomal recycling regulates Anthrax Toxin Receptor 1/Tumor Endothelial Marker 8-dependent cell spreading.
  Exp Cell Res Volume: 316 Page(s): 1946 - 1957
  07/15/2010 Authors: Gu J; Faundez V; Werner E
• The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3.
  J Cell Sci Volume: 120 Page(s): 3640 - 3652
  10/15/2007 Authors: Berger AC; Salazar G; Styers ML; Newell-Litwa KA; Werner E; Maue RA; Corbett AH; Faundez V
• BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes.
  Mol Biol Cell Volume: 17 Page(s): 4014 - 4026
  09/01/2006 Authors: Salazar G; Craige B; Styers ML; Newell-Litwa KA; Doucette MM; Wainer BH; Falcon-Perez JM; Dell'Angelica EC; Peden AA; Werner E
• Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton.
  J Biol Chem Volume: 281 Page(s): 23227 - 23236
  08/11/2006 Authors: Werner E; Kowalczyk AP; Faundez V
• Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen.
  J Biol Chem Volume: 280 Page(s): 40187 - 40194
  12/02/2005 Authors: Wall SJ; Werner E; Werb Z; DeClerck YA
• Genetic and biochemical analysis of the role of Egfr in the morphogenetic furrow of the developing Drosophila eye.
  Development Volume: 132 Page(s): 4697 - 4707
  11/01/2005 Authors: Rodrigues AB; Werner E; Moses K
• Axon regeneration in peripheral nerves is enhanced by proteoglycan degradation.
  Exp Neurol Volume: 195 Page(s): 278 - 292
  10/01/2005 Authors: Groves ML; McKeon R; Werner E; Nagarsheth M; Meador W; English AW
• Integrin clustering drives phagocytosis coupled to collagenase 1 induction through RhoA GTPase and superoxide production.
  Antioxid Redox Signal Volume: 7 Page(s): 318 - 326
  01/01/2005 Authors: Werner E
• AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells.
  J Biol Chem Volume: 279 Page(s): 25430 - 25439
  06/11/2004 Authors: Salazar G; Love R; Styers ML; Werner E; Peden A; Rodriguez S; Gearing M; Wainer BH; Faundez V
• The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation.
  Mol Biol Cell Volume: 15 Page(s): 575 - 587
  02/01/2004 Authors: Salazar G; Love R; Werner E; Doucette MM; Cheng S; Levey A; Faundez V
• GTPases and reactive oxygen species: switches for killing and signaling.
  J Cell Sci Volume: 117 Page(s): 143 - 153
  01/15/2004 Authors: Werner E
• Adaptor AP-3-dependent targeting of a chloride channel to synaptic vesicles
  Volume: 122 Page(s): 19A - 19A
  07/01/2003 Authors: Salazar G; Love R; Styers M; Werner E; Peden AA; Faundez V
• Determination of cellular H2O2 production.
  Sci STKE Volume: 2003 Page(s): PL3
  02/04/2003 Authors: Werner E
• Zinc transporter 3 (ZnT3) defines a distinct synaptic vesicles subpopulation
  Volume: 13 Page(s): 396A - 396A
  11/01/2002 Authors: Salazar G; Love R; Werner E; Cheng S; Levey A; Faundez V
• Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases.
  J Cell Biol Volume: 158 Page(s): 357 - 368
  07/22/2002 Authors: Werner E; Werb Z
• Phagocytosis mediated by Yersinia invasin induces collagenase-1 expression in rabbit synovial fibroblasts through a proinflammatory cascade.
  J Cell Sci Volume: 114 Page(s): 3333 - 3343
  09/01/2001 Authors: Werner E; Kheradmand F; Isberg RR; Werb Z
• Integrin-mediated phagocytosis induces collagenase 1 gene expression trough a RhoA dependent pathway
  MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 118A - 118A
  11/01/1998 Authors: Werner E; Kheradmand F; Werb Z
• Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change.
  Science Volume: 280 Page(s): 898 - 902
  05/08/1998 Authors: Kheradmand F; Werner E; Tremble P; Symons M; Werb Z
• Cell growth and Na-K-Cl cotransport responses of vascular smooth muscle cells of Milan rats.
  Volume: 23 Page(s): 1022 - 1026
  06/01/1994 Authors: Canessa M; Salazar G; Werner E; Vallega G; Gonzalez A
• PDGF STIMULATES CELL-GROWTH AND NAK-CL COTRANSPORT IN VASCULAR SMOOTH-MUSCLE CELLS OF MILAN HYPERTENSIVE RATS
  HYPERTENSION Volume: 22 Page(s): 438 - 438
  09/01/1993 Authors: CANESSA M; VALLEGA G; WERNER E; SALAZAR G; GONZALEZ A