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Profile

Eric Sundberg

  • Department of Biochemistry
    Professor
  • (404) 712-7301
  • eric.sundberg@emory.edu
  • Google Scholar
  • Lab website
  • Research Gate
  • PubMed
  • Emory University School of Medicine
    Biochemistry
    1510 Clifton Road, Room 4001
Head shot of Eric Sundberg

Overview

Eric attended the University of Rochester, where he earned Bachelors degrees in both Biochemistry and Economics in 1994. He pursued the former at Northwestern University, earning a Ph.D. in 1999 in the Inter-departmental Biological Sciences (IBiS) Program. At Northwestern, Eric was the first graduate student of Dr. Theodore S. Jardetzky (now in the Department of Structural Biology at the Stanford University School of Medicine).

Upon completion of his Ph.D., Eric became a postdoctoral fellow supported by an Arthritis Foundation fellowship in Dr. Roy A. Mariuzzas laboratory at the Center for Advanced Research in Biotechnology-University of Maryland Biotechnology Institute (CARB-UMBI; now the Institute for Bioscience and Biotechnology at the University of Maryland). He was promoted to Assistant Professor non-Tenure Track three years later and was awarded his first NIH grant shortly thereafter.

In 2004, Eric joined the faculty of the Boston Biomedical Research Institute (BBRI) as a Scientist (Tenure-Track Assistant Professor equivalent). He was promoted to Principal Scientist (Associate Professor equivalent) in 2009. In 2011, he moved his laboratory to the Institute of Human Virology and Departments of Medicine and of Microbiology & Immunology at the University of Maryland School of Medicine in Baltimore, where he was, most recently, Professor of Medicine and Co-Director of the Basic Science Division of the Institute of Human Virology.

In 2019, Eric moved to the Emory University School of Medicine, where he is now Professor and Chair of the Department of Biochemistry.

Academic Appointment

  • Professor and Chair, Biochemistry, Emory University School of Medicine

Education

Degrees

  • PhD from Northwestern University
  • BS from University of Rochester
  • BA from University of Rochester

Research

Publications

  • Oxidative Release of Natural Glycans (ORNG): Preparation of Truncated N-glycans for Engineering Glycoproteins.
    Chemistry Volume: 31 Page(s): e202501020
    06/06/2025 Authors: Zhang Q; Azzam T; Lasanajak Y; Sundberg EJ; Song X
  • Potent efficacy of an IgG-specific endoglycosidase against IgG-mediated pathologies.
    Cell Volume: 187 Page(s): 6994 - 7007.e12
    11/27/2024 Authors: Sastre DE; Bournazos S; Du J; Boder EJ; Edgar JE; Azzam T; Sultana N; Huliciak M; Flowers M; Yoza L
  • Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate.
    Nat Commun Volume: 15 Page(s): 5123
    06/15/2024 Authors: Sastre DE; Sultana N; V A S Navarro M; Huliciak M; Du J; Cifuente JO; Flowers M; Liu X; Lollar P; Trastoy B
  • Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling.
    Cell Rep Volume: 43 Page(s): 114099
    05/28/2024 Authors: Fields JK; Gyllenbck EJ; Bogacz M; Obi J; Birkedal GS; Sjstrm K; Maravillas K; Grnberg C; Rattik S; Kihn K
  • Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.
    Sci Adv Volume: 10 Page(s): eadk8157
    04/12/2024 Authors: Azzam T; Du JJ; Flowers MW; Ali AV; Hunn JC; Vijayvargiya N; Knagaram R; Bogacz M; Maravillas KE; Sastre DE
  • Modulating antibody effector functions by Fc glycoengineering.
    Biotechnol Adv Volume: 67 Page(s): 108201
    10/01/2023 Authors: Garca-Alija M; van Moer B; Sastre DE; Azzam T; Du JJ; Trastoy B; Callewaert N; Sundberg EJ; Guerin ME
  • Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody.
    Nat Commun Volume: 14 Page(s): 2853
    05/18/2023 Authors: Gupta A; Kao KS; Yamin R; Oren DA; Goldgur Y; Du J; Lollar P; Sundberg EJ; Ravetch JV
  • Croquemort elicits activation of the immune deficiency pathway in ticks.
    Proc Natl Acad Sci U S A Volume: 120 Page(s): e2208673120
    05/16/2023 Authors: O'Neal AJ; Singh N; Rolandelli A; Laukaitis HJ; Wang X; Shaw DK; Young BD; Narasimhan S; Dutta S; Snyder GA
  • An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments.
    PLoS Pathog Volume: 19 Page(s): e1010979
    05/01/2023 Authors: Nedeljkovi M; Kreutzberger MAB; Postel S; Bonsor D; Xing Y; Jacob N; Schuler WJ; Egelman EH; Sundberg EJ
  • Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.
    Nat Commun Volume: 14 Page(s): 1705
    03/27/2023 Authors: Trastoy B; Du JJ; Cifuente JO; Rudolph L; Garca-Alija M; Klontz EH; Deredge D; Sultana N; Huynh CG; Flowers MW
  • Mechanism of high-mannose N-glycan breakdown and metabolism by Bifidobacterium longum.
    Nat Chem Biol Volume: 19 Page(s): 218 - 229
    02/01/2023 Authors: Cordeiro RL; Santos CR; Domingues MN; Lima TB; Pirolla RAS; Morais MAB; Colombari FM; Miyamoto RY; Persinoti GF; Borges AC
  • Mechanism of glycoform specificity and protection against antibody dependent enhancement by an anti-afucosylated IgG nanobody.
    bioRxiv
    01/24/2023 Authors: Gupta A; Kao K; Yamin R; Oren DA; Goldgur Y; Du J; Lollar P; Sundberg EJ; Ravetch JV
  • Mass Spectrometry-Based Methods to Determine the Substrate Specificities and Kinetics of N-Linked Glycan Hydrolysis by Endo--N-Acetylglucosaminidases.
    Methods Mol Biol Volume: 2674 Page(s): 147 - 167
    01/01/2023 Authors: Du JJ; Sastre D; Trastoy B; Roberts B; Deredge D; Klontz EH; Flowers MW; Sultana N; Guerin ME; Sundberg EJ
  • The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification.
    RSC Med Chem Volume: 13 Page(s): 1276 - 1299
    11/16/2022 Authors: El-Khoury C; Mansour E; Yuliandra Y; Lai F; Hawkins BA; Du JJ; Sundberg EJ; Sluis-Cremer N; Hibbs DE; Groundwater PW
  • Highly ordered polymeric structure assemblies of endoglycosidases from the gut microbiome
    Volume: 32 Page(s): 1040 - 1041
    10/31/2022 Authors: Sastre DE; Du JJ; Cifuente JO; Sundberg EJ
  • Development of Improved Glycosynthase Enzymes
    Volume: 32 Page(s): 1016 - 1016
    10/31/2022 Authors: Azzam T; Du JJ; Sundberg EJ
  • Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE.
    Nat Commun Volume: 13 Page(s): 1137
    03/03/2022 Authors: Garca-Alija M; Du JJ; Ordez I; Diz-Vallenilla A; Moraleda-Montoya A; Sultana N; Huynh CG; Li C; Donahue TC; Wang L-X
  • Sculpting therapeutic monoclonal antibody N-glycans using endoglycosidases.
    Curr Opin Struct Biol Volume: 72 Page(s): 248 - 259
    02/01/2022 Authors: Trastoy B; Du JJ; Garca-Alija M; Li C; Klontz EH; Wang L-X; Sundberg EJ; Guerin ME
  • Semi-quantitative methods for multi-site deglycosylation events
    Volume: 31 Page(s): 1733 - 1734
    12/01/2021 Authors: Du J; Roberts B; Sundberg E; Deredge D
  • Structural and molecular analysis of endoglycosidases and SusD-like proteins reveal a possible cooperation for the import of N-glycans in the gut
    Volume: 31 Page(s): 1677 - 1678
    12/01/2021 Authors: Sastre D; Navarro MVAS; Sundberg EJ
  • Molecular Determinants of Filament Capping Proteins Required for the Formation of Functional Flagella in Gram-Negative Bacteria.
    Biomolecules Volume: 11
    09/22/2021 Authors: Nedeljkovi M; Postel S; Pierce BG; Sundberg EJ
  • GH18 endo--N-acetylglucosaminidases use distinct mechanisms to process hybrid-type N-linked glycans.
    J Biol Chem Volume: 297 Page(s): 101011
    08/01/2021 Authors: Trastoy B; Du JJ; Li C; Garca-Alija M; Klontz EH; Roberts BR; Donahue TC; Wang L-X; Sundberg EJ; Guerin ME
  • Biophysicists' continued outstanding response to COVID-19.
    Biophys J Volume: 120 Page(s): E1
    07/20/2021 Authors: Schlick T; Sundberg EJ; Schroeder SJ; Babu MM
  • Bacterial Flagellar Filament: A Supramolecular Multifunctional Nanostructure.
    Int J Mol Sci Volume: 22
    07/14/2021 Authors: Nedeljkovi M; Sastre DE; Sundberg EJ
  • Insights into substrate recognition and specificity for IgG by Endoglycosidase S2.
    PLoS Comput Biol Volume: 17 Page(s): e1009103
    07/01/2021 Authors: Aytenfisu AH; Deredge D; Klontz EH; Du J; Sundberg EJ; MacKerell AD
  • Lipid A mimetics BECC438 and BECC470 potentiate durable and balanced immune responses using an ovalbumin murine vaccine model
    Volume: 206
    05/01/2021 Authors: Harberts EM; Varisco DJ; Fields JK; Izac JR; Gardner FM; Sundberg EJ; Snyder GA; Ernst RK
  • Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors.
    EMBO J Volume: 40 Page(s): e106103
    04/01/2021 Authors: van Sorge NM; Bonsor DA; Deng L; Lindahl E; Schmitt V; Lyndin M; Schmidt A; Nilsson OR; Brizuela J; Boero E
  • Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium.
    Commun Biol Volume: 4 Page(s): 360
    03/19/2021 Authors: Gandhi AK; Sun Z-YJ; Kim WM; Huang Y-H; Kondo Y; Bonsor DA; Sundberg EJ; Wagner G; Kuchroo VK; Petsko GA
  • Biophysicists' outstanding response to Covid-19.
    Biophys J Volume: 120 Page(s): E1 - E2
    03/16/2021 Authors: Schlick T; Sundberg EJ; Schroeder SJ; Babu MM
  • Antibody Modeling using Molecular Dynamics and Silcs Fragmaps
    Volume: 120 Page(s): 83A - 83A
    02/12/2021 Authors: Aytenfisu AH; Deredge DJ; Klontz EH; Du J; Sundberg EJ; MacKerell AD
  • Congressional Budget Responses to the Pandemic: Fund Health Care, Not Warfare.
    Am J Public Health Volume: 111 Page(s): 200 - 201
    02/01/2021 Authors: King J; Goldenberg D; Goldstein G; Hartung W; Royer C; Sundberg E; van der Ziel C; Van Elzakker M; Roberts R
  • Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor.
    Front Immunol Volume: 12 Page(s): 779100
    01/01/2021 Authors: Fields JK; Kihn K; Birkedal GS; Klontz EH; Sjstrm K; Gnther S; Beadenkopf R; Forsberg G; Liberg D; Snyder GA
  • Structure and dynamics of an -fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
    Nat Commun Volume: 11 Page(s): 6204
    12/04/2020 Authors: Klontz EH; Li C; Kihn K; Fields JK; Beckett D; Snyder GA; Wintrode PL; Deredge D; Wang L-X; Sundberg EJ
  • Uphold the nuclear weapons test moratorium.
    Science Volume: 369 Page(s): 262
    07/17/2020 Authors: King J; Chalfie M; Chomsky N; Cirincione J; Decatur S; Franklin M; Gerson J; Goldenberg DP; Goldstein G; Hartung W
  • Structural insights into the mechanisms and specificities of IgG-active endoglycosidases.
    Glycobiology Volume: 30 Page(s): 268 - 279
    03/20/2020 Authors: Du JJ; Klontz EH; Guerin ME; Trastoy B; Sundberg EJ
  • CYTOKINES: FROM BASIC MECHANISMS OF CELLULAR CONTROL TO NEW THERAPEUTICS. Cold Spring Harbor Perspectives in Biology
    QUARTERLY REVIEW OF BIOLOGY Volume: 95 Page(s): 90 - 90
    03/01/2020 Authors: Nedeljkovic M; Sundberg EJ
  • Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides.
    Nat Commun Volume: 11 Page(s): 899
    02/14/2020 Authors: Trastoy B; Du JJ; Klontz EH; Li C; Cifuente JO; Wang L-X; Sundberg EJ; Guerin ME
  • Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy.
    Cell Res Volume: 29 Page(s): 609 - 627
    08/01/2019 Authors: Zhang Y; Du X; Liu M; Tang F; Zhang P; Ai C; Fields JK; Sundberg EJ; Latinovic OS; Devenport M
  • Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci.
    Am J Physiol Heart Circ Physiol Volume: 316 Page(s): H1480 - H1494
    06/01/2019 Authors: Xu MM; Mnoret A; Nicholas S-AE; Gnther S; Sundberg EJ; Zhou B; Rodriguez A; Murphy PA; Vella AT
  • Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.
    ACS Cent Sci Volume: 5 Page(s): 524 - 538
    03/27/2019 Authors: Klontz EH; Trastoy B; Deredge D; Fields JK; Li C; Orwenyo J; Marina A; Beadenkopf R; Gnther S; Flores J
  • Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens.
    Antimicrob Agents Chemother Volume: 63
    03/01/2019 Authors: Tomich AD; Klontz EH; Deredge D; Barnard JP; McElheny CL; Eshbach ML; Weisz OA; Wintrode P; Doi Y; Sundberg EJ
  • The structure of PilA from Acinetobacter baumannii AB5075 suggests a mechanism for functional specialization in Acinetobacter type IV pili.
    J Biol Chem Volume: 294 Page(s): 218 - 230
    01/04/2019 Authors: Ronish LA; Lillehoj E; Fields JK; Sundberg EJ; Piepenbrink KH
  • Structural Basis of IL-1 Family Cytokine Signaling.
    Front Immunol Volume: 10 Page(s): 1412
    01/01/2019 Authors: Fields JK; Gnther S; Sundberg EJ
  • Gastric Subserous Vaccination With Helicobacter pylori Vaccine: An Attempt to Establish Tissue-Resident CD4+ Memory T Cells and Induce Prolonged Protection.
    Front Immunol Volume: 10 Page(s): 1115
    01/01/2019 Authors: Liu W; Zeng Z; Luo S; Hu C; Xu N; Huang A; Zheng L; Sundberg EJ; Xi T; Xing Y
  • Roles of Adhesion to Epithelial Cells in Gastric Colonization by Helicobacter pylori.
    Adv Exp Med Biol Volume: 1149 Page(s): 57 - 75
    01/01/2019 Authors: Bonsor DA; Sundberg EJ
  • High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3.
    Sci Rep Volume: 8 Page(s): 17512
    11/30/2018 Authors: Gandhi AK; Kim WM; Sun Z-YJ; Huang Y-H; Bonsor DA; Sundberg EJ; Kondo Y; Wagner G; Kuchroo VK; Petsko G
  • The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA.
    EMBO J Volume: 37
    07/02/2018 Authors: Bonsor DA; Zhao Q; Schmidinger B; Weiss E; Wang J; Deredge D; Beadenkopf R; Dow B; Fischer W; Beckett D
  • Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S.
    Nat Commun Volume: 9 Page(s): 1874
    05/14/2018 Authors: Trastoy B; Klontz E; Orwenyo J; Marina A; Wang L-X; Sundberg EJ; Guerin ME
  • The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs for oncoprotein translocation
    Volume: 77 Page(s): 45 - 45
    04/01/2018 Authors: Bonsor DA; Zhao Q; Schmidinger B; Weiss E; Wang J; Deredge D; Beadenkopf R; Dow B; Fischer W; Beckett D
  • Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016).
    Proteins Volume: 86 Suppl 1 Page(s): 27 - 50
    03/01/2018 Authors: Kryshtafovych A; Albrecht R; Basl A; Bule P; Caputo AT; Carvalho AL; Chao KL; Diskin R; Fidelis K; Fontes CMGA
  • Structure and Dynamics of FosA-Mediated Fosfomycin Resistance in Klebsiella pneumoniae and Escherichia coli.
    Antimicrob Agents Chemother Volume: 61
    11/01/2017 Authors: Klontz EH; Tomich AD; Gnther S; Lemkul JA; Deredge D; Silverstein Z; Shaw JF; McElheny C; Doi Y; Wintrode PL
  • A structural model of flagellar filament switching across multiple bacterial species.
    Nat Commun Volume: 8 Page(s): 960
    10/16/2017 Authors: Wang F; Burrage AM; Postel S; Clark RE; Orlova A; Sundberg EJ; Kearns DB; Egelman EH
  • Structure-Based Design of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses to a Conserved Epitope.
    J Virol Volume: 91
    10/15/2017 Authors: Pierce BG; Boucher EN; Piepenbrink KH; Ejemel M; Rapp CA; Thomas WD; Sundberg EJ; Weng Z; Wang Y
  • IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor.
    Immunity Volume: 47 Page(s): 510 - 523.e4
    09/19/2017 Authors: Gnther S; Deredge D; Bowers AL; Luchini A; Bonsor DA; Beadenkopf R; Liotta L; Wintrode PL; Sundberg EJ
  • Getting oriented with antibodies.
    Biochem J Volume: 474 Page(s): 517 - 519
    02/15/2017 Authors: Klontz EH; Sundberg EJ
  • Infection-derived lipids elicit an immune deficiency circuit in arthropods.
    Nat Commun Volume: 8 Page(s): 14401
    02/14/2017 Authors: Shaw DK; Wang X; Brown LJ; Chvez ASO; Reif KE; Smith AA; Scott AJ; McClure EE; Boradia VM; Hammond HL
  • Common Challenges in Studying the Structure and Function of Bacterial Proteins: Case Studies from Helicobacter pylori.
    Methods Mol Biol Volume: 1535 Page(s): 77 - 93
    01/01/2017 Authors: Bonsor DA; Sundberg EJ
  • Motility and adhesion through type IV pili in Gram-positive bacteria.
    Biochem Soc Trans Volume: 44 Page(s): 1659 - 1666
    12/15/2016 Authors: Piepenbrink KH; Sundberg EJ
  • Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240.
    Sci Rep Volume: 6 Page(s): 36685
    11/09/2016 Authors: Gohain N; Tolbert WD; Orlandi C; Richard J; Ding S; Chen X; Bonsor DA; Sundberg EJ; Lu W; Ray K
  • Erratum: Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA.
    Nat Microbiol Volume: 2 Page(s): 16233
    10/31/2016 Authors: Kniger V; Holsten L; Harrison U; Busch B; Loell E; Zhao Q; Bonsor DA; Roth A; Kengmo-Tchoupa A; Smith SI
  • Structural Diversity in the Type IV Pili of Multidrug-resistant Acinetobacter.
    J Biol Chem Volume: 291 Page(s): 22924 - 22935
    10/28/2016 Authors: Piepenbrink KH; Lillehoj E; Harding CM; Labonte JW; Zuo X; Rapp CA; Munson RS; Goldblum SE; Feldman MF; Gray JJ
  • Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA.
    Nat Microbiol Volume: 2 Page(s): 16188
    10/17/2016 Authors: Kniger V; Holsten L; Harrison U; Busch B; Loell E; Zhao Q; Bonsor DA; Roth A; Kengmo-Tchoupa A; Smith SI
  • Bacterial flagellar capping proteins adopt diverse oligomeric states.
    Elife Volume: 5
    09/24/2016 Authors: Postel S; Deredge D; Bonsor DA; Yu X; Diederichs K; Helmsing S; Vromen A; Friedler A; Hust M; Egelman EH
  • Some of the most interesting CASP11 targets through the eyes of their authors.
    Proteins Volume: 84 Suppl 1 Page(s): 34 - 50
    09/01/2016 Authors: Kryshtafovych A; Moult J; Basl A; Burgin A; Craig TK; Edwards RA; Fass D; Hartmann MD; Korycinski M; Lewis RJ
  • The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo.
    Glycobiology Volume: 26 Page(s): 834 - 849
    08/01/2016 Authors: Hyun SW; Liu A; Liu Z; Cross AS; Verceles AC; Magesh S; Kommagalla Y; Kona C; Ando H; Luzina IG
  • Type IV pili promote early biofilm formation by Clostridium difficile.
    Pathog Dis Volume: 74
    08/01/2016 Authors: Maldarelli GA; Piepenbrink KH; Scott AJ; Freiberg JA; Song Y; Achermann Y; Ernst RK; Shirtliff ME; Sundberg EJ; Donnenberg MS
  • The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation.
    Infect Immun Volume: 84 Page(s): 1796 - 1805
    06/01/2016 Authors: Wang X; Shaw DK; Sakhon OS; Snyder GA; Sundberg EJ; Santambrogio L; Sutterwala FS; Dumler JS; Shirey KA; Perkins DJ
  • Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.
    J Virol Volume: 89 Page(s): 11820 - 11833
    12/01/2015 Authors: Taylor JK; Coleman CM; Postel S; Sisk JM; Bernbaum JG; Venkataraman T; Sundberg EJ; Frieman MB
  • Diverse oligomeric states of CEACAM IgV domains.
    Proc Natl Acad Sci U S A Volume: 112 Page(s): 13561 - 13566
    11/03/2015 Authors: Bonsor DA; Gnther S; Beadenkopf R; Beckett D; Sundberg EJ
  • Synthetic, structural mimetics of the -hairpin flap of HIV-1 protease inhibit enzyme function.
    Bioorg Med Chem Volume: 23 Page(s): 7095 - 7109
    11/01/2015 Authors: Chauhan J; Chen S-E; Fenstermacher KJ; Naser-Tavakolian A; Reingewertz T; Salmo R; Lee C; Williams E; Raje M; Sundberg E
  • Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
    Volume: 76 Page(s): 87 - 87
    11/01/2015 Authors: Guenther S; Sundberg EJ
  • Structure of the N-terminal dimerization domain of CEACAM7.
    Acta Crystallogr F Struct Biol Commun Volume: 71 Page(s): 1169 - 1175
    09/01/2015 Authors: Bonsor DA; Beckett D; Sundberg EJ
  • A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza.
    Cell Rep Volume: 11 Page(s): 1941 - 1952
    06/30/2015 Authors: Piao W; Shirey KA; Ru LW; Lai W; Szmacinski H; Snyder GA; Sundberg EJ; Lakowicz JR; Vogel SN; Toshchakov VY
  • An Intrinsically Disordered Region in the Proapoptotic ASPP2 Protein Binds to the Helicobacter pylori Oncoprotein CagA.
    Biochemistry Volume: 54 Page(s): 3337 - 3347
    06/02/2015 Authors: Reingewertz TH; Iosub-Amir A; Bonsor DA; Mayer G; Amartely H; Friedler A; Sundberg EJ
  • Integrin engagement by the helical RGD motif of the Helicobacter pylori CagL protein is regulated by pH-induced displacement of a neighboring helix.
    J Biol Chem Volume: 290 Page(s): 12929 - 12940
    05/15/2015 Authors: Bonsor DA; Pham KT; Beadenkopf R; Diederichs K; Haas R; Beckett D; Fischer W; Sundberg EJ
  • Microbial Manipulation of Antibody Effector Functions
    Volume: 29
    04/01/2015 Authors: Sundberg E
  • Structural and evolutionary analyses show unique stabilization strategies in the type IV pili of Clostridium difficile.
    Structure Volume: 23 Page(s): 385 - 396
    02/03/2015 Authors: Piepenbrink KH; Maldarelli GA; Martinez de la Pea CF; Dingle TC; Mulvey GL; Lee A; von Rosenvinge E; Armstrong GD; Donnenberg MS; Sundberg EJ
  • Crystal structure of EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies.
    Volume: 67 Page(s): 86 - 86
    11/01/2014 Authors: Trastoy B; Lomino J; Wang L-X; Sundberg E
  • Molecular determinants of agonist and antagonist signaling through the IL-36 receptor
    Volume: 67 Page(s): 84 - 84
    11/01/2014 Authors: Guenther S; Sundberg E
  • A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice.
    J Infect Dis Volume: 210 Page(s): 964 - 972
    09/15/2014 Authors: Yang Z; Schmidt D; Liu W; Li S; Shi L; Sheng J; Chen K; Yu H; Tremblay JM; Chen X
  • Molecular determinants of agonist and antagonist signaling through the IL-36 receptor.
    J Immunol Volume: 193 Page(s): 921 - 930
    07/15/2014 Authors: Gnther S; Sundberg EJ
  • The tick salivary protein sialostatin L2 inhibits caspase-1-mediated inflammation during Anaplasma phagocytophilum infection.
    Infect Immun Volume: 82 Page(s): 2553 - 2564
    06/01/2014 Authors: Chen G; Wang X; Severo MS; Sakhon OS; Sohail M; Brown LJ; Sircar M; Snyder GA; Sundberg EJ; Ulland TK
  • Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): 6714 - 6719
    05/06/2014 Authors: Trastoy B; Lomino JV; Pierce BG; Carter LG; Gnther S; Giddens JP; Snyder GA; Weiss TM; Weng Z; Wang L-X
  • Development of microbial-derived inhibitory peptides using structural studies of microbial TIR proteins TcpB, TcpC and host adapters TIRAP and MyD88.
    Volume: 192
    05/01/2014 Authors: Snyder G; Deredge D; Waldhuber A; Fresquez T; Smith P; Duerr S; Cirl C; Jiang J; Jennings W; Luchetti T
  • Inhibition of TLR2 signaling by small molecule inhibitors targeting a novel putative pocket within the TLR2 TIR domain
    Volume: 192
    05/01/2014 Authors: Mistry P; Laird M; Schwarz R; Greene S; Dyson T; Jabre S; Snyder G; Deredge D; Chauhan J; Wintrode P
  • Structure of Clostridium difficile PilJ exhibits unprecedented divergence from known type IV pilins.
    J Biol Chem Volume: 289 Page(s): 4334 - 4345
    02/14/2014 Authors: Piepenbrink KH; Maldarelli GA; de la Pea CFM; Mulvey GL; Snyder GA; De Masi L; von Rosenvinge EC; Gnther S; Armstrong GD; Donnenberg MS
  • Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry.
    J Biol Chem Volume: 289 Page(s): 669 - 679
    01/10/2014 Authors: Snyder GA; Deredge D; Waldhuber A; Fresquez T; Wilkins DZ; Smith PT; Durr S; Cirl C; Jiang J; Jennings W
  • Molecular interactions in interleukin and toll-like receptor signaling pathways.
    Curr Pharm Des Volume: 20 Page(s): 1244 - 1258
    01/01/2014 Authors: Snyder GA; Sundberg EJ
  • Characterization of the Staphylococcal enterotoxin A: V receptor interaction using human receptor fragments engineered for high affinity.
    Protein Eng Des Sel Volume: 26 Page(s): 781 - 789
    12/01/2013 Authors: Sharma P; Postel S; Sundberg EJ; Kranz DM
  • Liquid-liquid diffusion crystallization improves the X-ray diffraction of EndoS, an endo--N-acetylglucosaminidase from Streptococcus pyogenes with activity on human IgG.
    Acta Crystallogr Sect F Struct Biol Cryst Commun Volume: 69 Page(s): 1405 - 1410
    12/01/2013 Authors: Trastoy B; Lomino JV; Wang LX; Sundberg EJ
  • Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain.
    Proc Natl Acad Sci U S A Volume: 110 Page(s): 19036 - 19041
    11/01/2013 Authors: Piao W; Ru LW; Piepenbrink KH; Sundberg EJ; Vogel SN; Toshchakov VY
  • Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF.
    J Biol Chem Volume: 288 Page(s): 32897 - 32909
    11/15/2013 Authors: Bonsor DA; Weiss E; Iosub-Amir A; Reingewertz TH; Chen TW; Haas R; Friedler A; Fischer W; Sundberg EJ
  • With an antibody whose duty's double, a step towards ending asthma trouble?
    Biochem J Volume: 451 Page(s): e1 - e3
    04/15/2013 Authors: Sundberg EJ
  • Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease.
    Protein Eng Des Sel Volume: 26 Page(s): 133 - 142
    02/01/2013 Authors: Mattis DM; Spaulding AR; Chuang-Smith ON; Sundberg EJ; Schlievert PM; Kranz DM
  • R753Q polymorphism inhibits Toll-like receptor (TLR) 2 tyrosine phosphorylation, dimerization with TLR6, and recruitment of myeloid differentiation primary response protein 88.
    J Biol Chem Volume: 287 Page(s): 38327 - 38337
    11/02/2012 Authors: Xiong Y; Song C; Snyder GA; Sundberg EJ; Medvedev AE
  • Molecular basis of a million-fold affinity maturation process in a protein-protein interaction.
    J Mol Biol Volume: 411 Page(s): 321 - 328
    08/12/2011 Authors: Bonsor DA; Postel S; Pierce BG; Wang N; Zhu P; Buonpane RA; Weng Z; Kranz DM; Sundberg EJ
  • Dissecting protein-protein interactions using directed evolution.
    Biochemistry Volume: 50 Page(s): 2394 - 2402
    04/05/2011 Authors: Bonsor DA; Sundberg EJ
  • The T cell receptor beta-chain second complementarity determining region loop (CDR2beta governs T cell activation and Vbeta specificity by bacterial superantigens.
    J Biol Chem Volume: 286 Page(s): 4871 - 4881
    02/11/2011 Authors: Nur-ur Rahman AKM; Bonsor DA; Herfst CA; Pollard F; Peirce M; Wyatt AW; Kasper KJ; Madrenas J; Sundberg EJ; McCormick JK
  • A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.
    J Exp Med Volume: 208 Page(s): 91 - 102
    01/17/2011 Authors: Sethi DK; Schubert DA; Anders A-K; Heroux A; Bonsor DA; Thomas CP; Sundberg EJ; Pyrdol J; Wucherpfennig KW
  • HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide.
    Nat Immunol Volume: 12 Page(s): 54 - 61
    01/01/2011 Authors: Anders A-K; Call MJ; Schulze M-SED; Fowler KD; Schubert DA; Seth NP; Sundberg EJ; Wucherpfennig KW
  • Assessing energetic contributions to binding from a disordered region in a protein-protein interaction .
    Biochemistry Volume: 49 Page(s): 9256 - 9268
    11/02/2010 Authors: Cho S; Swaminathan CP; Bonsor DA; Kerzic MC; Guan R; Yang J; Kieke MC; Andersen PS; Kranz DM; Mariuzza RA
  • A single, engineered protein therapeutic agent neutralizes exotoxins from both Staphylococcus aureus and Streptococcus pyogenes.
    Clin Vaccine Immunol Volume: 17 Page(s): 1781 - 1789
    11/01/2010 Authors: Wang N; Mattis DM; Sundberg EJ; Schlievert PM; Kranz DM
  • Par-4: a new activator of myosin phosphatase.
    Mol Biol Cell Volume: 21 Page(s): 1214 - 1224
    04/01/2010 Authors: Vetterkind S; Lee E; Sundberg E; Poythress RH; Tao TC; Preuss U; Morgan KG
  • The TCR beta-chain CDR2 Loop Governs V beta-specificity by Bacterial Superantigens
    Volume: 135 Page(s): S54 - S54
    01/01/2010 Authors: Rahman N-U; Pollard F; Herfst C; Peirce M; Wyatt A; Brouillard J-N; Kasper K; Madrenas J; Sundberg E; McCormick J
  • HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses.
    J Exp Med Volume: 206 Page(s): 2959 - 2966
    12/21/2009 Authors: Huang J; Goedert JJ; Sundberg EJ; Cung TDH; Burke PS; Martin MP; Preiss L; Lifson J; Lichterfeld M; Carrington M
  • Structural basis of antibody-antigen interactions.
    Methods Mol Biol Volume: 524 Page(s): 23 - 36
    01/01/2009 Authors: Sundberg EJ
  • Molecular recognition of diverse ligands by T-cell receptors.
    Methods Mol Biol Volume: 524 Page(s): 347 - 359
    01/01/2009 Authors: Sundberg EJ
  • Molecular requirements for MHC class II alpha-chain engagement and allelic discrimination by the bacterial superantigen streptococcal pyrogenic exotoxin C.
    J Immunol Volume: 181 Page(s): 3384 - 3392
    09/01/2008 Authors: Kasper KJ; Xi W; Rahman AKMN-U; Nooh MM; Kotb M; Sundberg EJ; Madrenas J; McCormick JK
  • Neutralization of multiple staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats.
    J Infect Dis Volume: 198 Page(s): 344 - 348
    08/01/2008 Authors: Yang X; Buonpane RA; Moza B; Rahman AKMN-U; Wang N; Schlievert PM; McCormick JK; Sundberg EJ; Kranz DM
  • Regulation of Ca2+/calmodulin kinase II by a small C-terminal domain phosphatase.
    Biochem J Volume: 412 Page(s): 507 - 516
    06/15/2008 Authors: Gangopadhyay SS; Gallant C; Sundberg EJ; Lane WS; Morgan KG
  • A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells.
    J Exp Med Volume: 204 Page(s): 2813 - 2824
    11/26/2007 Authors: Lichterfeld M; Kavanagh DG; Williams KL; Moza B; Mui SK; Miura T; Sivamurthy R; Allgaier R; Pereyra F; Trocha A
  • Interactions between the leucine-zipper motif of cGMP-dependent protein kinase and the C-terminal region of the targeting subunit of myosin light chain phosphatase.
    J Mol Biol Volume: 373 Page(s): 1198 - 1212
    11/09/2007 Authors: Lee E; Hayes DB; Langsetmo K; Sundberg EJ; Tao TC
  • A novel loop domain in superantigens extends their T cell receptor recognition site.
    J Mol Biol Volume: 371 Page(s): 210 - 221
    08/03/2007 Authors: Gnther S; Varma AK; Moza B; Kasper KJ; Wyatt AW; Zhu P; Rahman AKMN-U; Li Y; Mariuzza RA; McCormick JK
  • TCR recognition of peptide/MHC class II complexes and superantigens.
    Semin Immunol Volume: 19 Page(s): 262 - 271
    08/01/2007 Authors: Sundberg EJ; Deng L; Mariuzza RA
  • Recombinant expression and purification of the N-terminal extracellular domain of the parathyroid hormone receptor.
    Protein Expr Purif Volume: 54 Page(s): 87 - 93
    07/01/2007 Authors: Monaghan P; Woznica I; Moza B; Sundberg EJ; Rosenblatt M
  • Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists.
    Nat Med Volume: 13 Page(s): 725 - 729
    06/01/2007 Authors: Buonpane RA; Churchill HRO; Moza B; Sundberg EJ; Peterson ML; Schlievert PM; Kranz DM
  • Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by group V superantigens.
    J Mol Biol Volume: 367 Page(s): 925 - 934
    04/06/2007 Authors: Brouillard J-NP; Gnther S; Varma AK; Gryski I; Herfst CA; Rahman AKMN-U; Leung DYM; Schlievert PM; Madrenas J; Sundberg EJ
  • Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1.
    EMBO J Volume: 26 Page(s): 1187 - 1197
    02/21/2007 Authors: Moza B; Varma AK; Buonpane RA; Zhu P; Herfst CA; Nicholson MJ; Wilbuer A-K; Seth NP; Wucherpfennig KW; McCormick JK
  • Molecular basis of TCR selectivity, cross-reactivity, and allelic discrimination by a bacterial superantigen: integrative functional and energetic mapping of the SpeC-Vbeta2.1 molecular interface.
    J Immunol Volume: 177 Page(s): 8595 - 8603
    12/15/2006 Authors: Rahman AKMN-U; Herfst CA; Moza B; Shames SR; Chau LA; Bueno C; Madrenas J; Sundberg EJ; McCormick JK
  • Long-range cooperative binding effects in a T cell receptor variable domain.
    Proc Natl Acad Sci U S A Volume: 103 Page(s): 9867 - 9872
    06/27/2006 Authors: Moza B; Buonpane RA; Zhu P; Herfst CA; Rahman AKMN-U; McCormick JK; Kranz DM; Sundberg EJ
  • Engineering soluble, high-affinity receptor antagonists of bacterial enterotoxins
    Volume: 176 Page(s): S99 - S99
    04/01/2006 Authors: Buonpane RA; Churchill HRO; Moza B; Sundberg EJ; Schlievert PM; Kranz DM
  • Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.
    Structure Volume: 13 Page(s): 1775 - 1787
    12/01/2005 Authors: Cho S; Swaminathan CP; Yang J; Kerzic MC; Guan R; Kieke MC; Kranz DM; Mariuzza RA; Sundberg EJ
  • Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1.
    J Mol Biol Volume: 353 Page(s): 308 - 321
    10/21/2005 Authors: Buonpane RA; Moza B; Sundberg EJ; Kranz DM
  • Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution.
    J Mol Biol Volume: 347 Page(s): 683 - 691
    04/08/2005 Authors: Guan R; Wang Q; Sundberg EJ; Mariuzza RA
  • Cloning, expression and interaction of human T-cell receptors with the bacterial superantigen SSA.
    Eur J Biochem Volume: 271 Page(s): 4075 - 4083
    10/01/2004 Authors: De Marz MC; Fernndez MM; Sundberg EJ; Molinero L; Zwirner NW; Llera AS; Mariuzza RA; Malchiodi EL
  • Structural mechanism governing cis and trans isomeric states and an intramolecular switch for cis/trans isomerization of a non-proline peptide bond observed in crystal structures of scorpion toxins.
    J Mol Biol Volume: 341 Page(s): 1189 - 1204
    08/27/2004 Authors: Guan R-J; Xiang Y; He X-L; Wang C-G; Wang M; Zhang Y; Sundberg EJ; Wang D-C
  • Dissecting cooperative and additive binding energetics in the affinity maturation pathway of a protein-protein interface.
    J Biol Chem Volume: 278 Page(s): 50412 - 50421
    12/12/2003 Authors: Yang J; Swaminathan CP; Huang Y; Guan R; Cho S; Kieke MC; Kranz DM; Mariuzza RA; Sundberg EJ
  • Exploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1.
    J Biol Chem Volume: 278 Page(s): 44904 - 44912
    11/07/2003 Authors: Zavala-Ruiz Z; Sundberg EJ; Stone JD; DeOliveira DB; Chan IC; Svendsen J; Mariuzza RA; Stern LJ
  • Structural, energetic, and functional analysis of a protein-protein interface at distinct stages of affinity maturation.
    Structure Volume: 11 Page(s): 1151 - 1161
    09/01/2003 Authors: Sundberg EJ; Andersen PS; Schlievert PM; Karjalainen K; Mariuzza RA
  • Functional analysis of the TCR binding domain of toxic shock syndrome toxin-1 predicts further diversity in MHC class II/superantigen/TCR ternary complexes.
    J Immunol Volume: 171 Page(s): 1385 - 1392
    08/01/2003 Authors: McCormick JK; Tripp TJ; Llera AS; Sundberg EJ; Dinges MM; Mariuzza RA; Schlievert PM
  • Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line.
    J Mol Biol Volume: 319 Page(s): 449 - 461
    05/31/2002 Authors: Sundberg EJ; Sawicki MW; Southwood S; Andersen PS; Sette A; Mariuzza RA
  • Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.
    Structure Volume: 10 Page(s): 687 - 699
    05/01/2002 Authors: Sundberg EJ; Li H; Llera AS; McCormick JK; Tormo J; Schlievert PM; Karjalainen K; Mariuzza RA
  • Quantifying the energetics of cooperativity in a ternary protein complex.
    Biochemistry Volume: 41 Page(s): 5177 - 5184
    04/23/2002 Authors: Andersen PS; Schuck P; Sundberg EJ; Geisler C; Karjalainen K; Mariuzza RA
  • So many ways of getting in the way: diversity in the molecular architecture of superantigen-dependent T-cell signaling complexes.
    Curr Opin Immunol Volume: 14 Page(s): 36 - 44
    02/01/2002 Authors: Sundberg EJ; Li Y; Mariuzza RA
  • Molecular recognition in antibody-antigen complexes.
    Adv Protein Chem Volume: 61 Page(s): 119 - 160
    01/01/2002 Authors: Sundberg EJ; Mariuzza RA
  • High affinity T cell receptors from yeast display libraries block T cell activation by superantigens.
    J Mol Biol Volume: 307 Page(s): 1305 - 1315
    04/13/2001 Authors: Kieke MC; Sundberg E; Shusta EV; Mariuzza RA; Wittrup KD; Kranz DM
  • Estimation of the hydrophobic effect in an antigen-antibody protein-protein interface.
    Biochemistry Volume: 39 Page(s): 15375 - 15387
    12/19/2000 Authors: Sundberg EJ; Urrutia M; Braden BC; Isern J; Tsuchiya D; Fields BA; Malchiodi EL; Tormo J; Schwarz FP; Mariuzza RA
  • Luxury accommodations: the expanding role of structural plasticity in protein-protein interactions.
    Structure Volume: 8 Page(s): R137 - R142
    07/15/2000 Authors: Sundberg EJ; Mariuzza RA
  • Structural basis for HLA-DQ binding by the streptococcal superantigen SSA.
    Nat Struct Biol Volume: 6 Page(s): 123 - 129
    02/01/1999 Authors: Sundberg E; Jardetzky TS
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