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Profile

Eric Ortlund PhD

  • Department of Biochemistry
    Professor
  • (404) 727-5014
  • eortlun@emory.edu
  • Ortlund Lab website
  • Emory University
    Biochemistry
    1510 Clifton Rd. NE Room 4017
Head shot of Eric Ortlund

Overview

Dr. Ortlund is a Professor of Biochemistry at Emory University School of Medicine. His lab uses structural, biochemical and biophysical approaches to study lipid signaling, transcriptional control and host-pathogen interactions. He is the Scientific Director of the Emory Integrated Metabolomics and Lipidomics Core.

Academic Appointment

  • Vice Chair of Biochemistry, Biochemistry, Emory University School of Medicine
  • Professor, Biochemistry, Emory University School of Medicine

Education

Degrees

  • PhD from University of South Carolina
  • BS from University of South Carolina

Research

Publications

  • Mapping affinity and allostery in human IgG antibody Fc region-Fc receptor interactions.

    04/01/2025 Authors: Keith AD; Xu T; Chernova TA; Keen MM; Bogacz M; Nedeljkovi M; Flowers M; Brown T; Frank F; Ortlund EA
  • Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer's Dementia to Living Humans.
    bioRxiv
    03/24/2025 Authors: Iturria-Medina Y; Poole VN; Zammit AR; Yu L; Tasaki S; Hong JH; Lopes KDP; Batalha C; Ridwan AR; Vialle RA
  • The Design and Immunogenicity of an HIV-1 Clade C Pediatric Envelope Glycoprotein Stabilized by Multiple Platforms.
    Vaccines (Basel) Volume: 13
    01/22/2025 Authors: Kumar S; Moral-Snchez ID; Singh S; Newby ML; Allen JD; Bijl TPL; Vaghani Y; Jing L; Lodha R; Ortlund EA
  • Epitope mapping via invitro deep mutational scanning methods and its applications.
    J Biol Chem Volume: 301 Page(s): 108072
    01/01/2025 Authors: Keen MM; Keith AD; Ortlund EA
  • Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog.
    J Biol Chem Volume: 301 Page(s): 108074
    01/01/2025 Authors: Weinberg J; Liu KH; Lee C-M; Crandall WJ; Cuevas AR; Druzak SA; Morgan ET; Jarrell ZR; Ortlund EA; Martin GS
  • Structural dynamics and binding of Caenorhabditis elegans lifespan-extending lipid binding protein-3 to polyunsaturated fatty acids.
    Protein Sci Volume: 34 Page(s): e5249
    01/01/2025 Authors: Cuevas AR; Tillman MC; Wang MC; Ortlund EA
  • A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose.
    NPJ Vaccines Volume: 9 Page(s): 255
    12/23/2024 Authors: Rostad CA; Yildirim I; Kao C; Yi J; Kamidani S; Peters E; Stephens K; Gibson T; Hsiao H-M; Singh K
  • Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
    Nature Volume: 636 Page(s): E9
    12/01/2024 Authors: Blanchard JW; Akay LA; Davila-Velderrain J; von Maydell D; Mathys H; Davidson SM; Effenberger A; Chen C-Y; Maner-Smith K; Hajjar I
  • Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk.
    Nat Commun Volume: 15 Page(s): 10201
    11/25/2024 Authors: Oshinowo O; Copeland R; Patel A; Shaver N; Fay ME; Jeltuhin R; Xiang Y; Caruso C; Otumala AE; Hernandez S
  • Endurance Exercise Training Alters Lipidomic Profiles of Plasma and Eight Tissues in Rats: a MoTrPAC study.

    11/21/2024 Authors: Ortlund E; Hou Z; Chen C-Y; Gaul D; Zhang T; Moore S; Liu X; Ivanova A; Maner-Smith K; Newgard C
  • Activity and phosphatidylcholine transfer protein interactions of skeletal muscle thioesterase Them2 enable hepatic steatosis and insulin resistance.
    J Biol Chem Volume: 300 Page(s): 107855
    11/01/2024 Authors: Xie Y; Liu X; Liu W; Carr LR; Lee LP; Imai N; Ortlund EA; Cohen DE
  • Design and immunogenicity of an HIV-1 clade C pediatric envelope glycoprotein stabilized by multiple platforms.

    09/19/2024 Authors: Kumar S; Del Moral-Snchez I; Singh S; Newby ML; Allen JD; Bijl TPL; Vaghani Y; Jing L; Ortlund EA; Crispin M
  • Structure, function, and lipid sensing activity in the thioesterase superfamily.
    Biochem Soc Trans Volume: 52 Page(s): 1565 - 1577
    08/28/2024 Authors: Little M; Ortlund EA
  • Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).
    Function (Oxf) Volume: 5
    07/11/2024 Authors: Schenk S; Sagendorf TJ; Many GM; Lira AK; de Sousa LGO; Bae D; Cicha M; Kramer KS; Muehlbauer M; Hevener AL
  • The impact of exercise on gene regulation in association with complex trait genetics.
    Nat Commun Volume: 15 Page(s): 3346
    05/01/2024 Authors: Vetr NG; Gay NR; MoTrPAC Study Group; Montgomery SB
  • Temporal dynamics of the multi-omic response to endurance exercise training.
    Nature Volume: 629 Page(s): 174 - 183
    05/01/2024 Authors: MoTrPACStudy Group; Lead Analysts; MoTrPAC Study Group
  • Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.
    Nat Metab Volume: 6 Page(s): 963 - 979
    05/01/2024 Authors: Many GM; Sanford JA; Sagendorf TJ; Hou Z; Nigro P; Whytock KL; Amar D; Caputo T; Gay NR; Gaul DA
  • Lipidome Changes Associated with a Diet-Induced Reduction in Hepatic Fat among Adolescent Boys with Metabolic Dysfunction-Associated Steatotic Liver Disease.
    Metabolites Volume: 14
    03/28/2024 Authors: Huneault HE; Chen C-Y; Cohen CC; Liu X; Jarrell ZR; He Z; DeSantos KE; Welsh JA; Maner-Smith KM; Ortlund EA
  • Integrative brain omics approach reveals key role for sn-1 lysophosphatidylethanolamine in Alzheimer's dementia.

    02/27/2024 Authors: Ortlund E; Chen C-Y; Maner-Smith K; Khadka M; Ahn J; Gulbin X; Ivanova A; Dammer E; Seyfried N; Bennett D
  • FABP5-binding lipids regulate autophagy in differentiated SH-SY5Y cells.
    PLoS One Volume: 19 Page(s): e0300168
    01/01/2024 Authors: Soto-Avellaneda A; Oxford AE; Halla F; Vasquez P; Oe E; Pugel AD; Schoenfeld AM; Tillman MC; Cuevas A; Ortlund EA
  • Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes.
    Mol Cell Endocrinol Volume: 578 Page(s): 112068
    12/01/2023 Authors: Proffitt MR; Liu X; Ortlund EA; Smith GT
  • High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease.
    Mol Metab Volume: 78 Page(s): 101832
    12/01/2023 Authors: Krumm CS; Landzberg RS; Ramos-Espiritu L; Adura C; Liu X; Acuna M; Xie Y; Xu X; Tillman MC; Li Y
  • Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against Wuhan-WT, delta and omicron BA1, BA2 spike trimers.
    iScience Volume: 26 Page(s): 108256
    11/17/2023 Authors: Cheedarla N; Verkerke HP; Potlapalli S; McLendon KB; Patel A; Frank F; O'Sick WH; Cheedarla S; Baugh TJ; Damhorst GL
  • Sensitivity of rapid antigen tests against SARS-CoV-2 Omicron and Delta variants.
    J Clin Microbiol Volume: 61 Page(s): e0013823
    10/24/2023 Authors: Rao A; Westbrook A; Bassit L; Parsons R; Fitts E; Greenleaf M; McLendon K; Sullivan JA; O'Sick W; Baugh T
  • The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits.
    Protein Sci Volume: 32 Page(s): e4754
    10/01/2023 Authors: Mays SG; Hercules D; Ortlund EA; Okafor CD
  • Light chain of a public SARS-CoV-2 class-3 antibody modulates neutralization against Omicron.
    Cell Rep Volume: 42 Page(s): 113150
    09/26/2023 Authors: Patel A; Kumar S; Lai L; Keen M; Valanparambil R; Chakravarthy C; Laughlin Z; Frank F; Cheedarla N; Verkerke HP
  • Correction to 'DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining'.
    Nucleic Acids Res Volume: 51 Page(s): 9507
    09/22/2023
  • DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining.
    Nucleic Acids Res Volume: 51 Page(s): 7972 - 7987
    08/25/2023 Authors: Head PE; Kapoor-Vazirani P; Nagaraju GP; Zhang H; Rath SK; Luong NC; Haji-Seyed-Javadi R; Sesay F; Wang S-Y; Duong DM
  • Comparison of activity, structure, and dynamics of SF-1 and LRH-1 complexed with small molecule modulators.
    J Biol Chem Volume: 299 Page(s): 104921
    08/01/2023 Authors: Cato ML; D'Agostino EH; Spurlin RM; Flynn AR; Cornelison JL; Johnson AM; Fujita RA; Abraham SM; Jui NT; Ortlund EA
  • Meet the authors: Dr. Eva Huber, Dr. Michael Groll, and Dr. Eric Ortlund.
    Structure Volume: 31 Page(s): 762 - 763
    07/06/2023 Authors: Huber E; Groll M; Ortlund E
  • Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response.
    Structure Volume: 31 Page(s): 801 - 811.e5
    07/06/2023 Authors: Patel A; Kumar S; Lai L; Chakravarthy C; Valanparambil R; Reddy ES; Gottimukkala K; Bajpai P; Raju DR; Edara VV
  • Acyl-CoA thioesterase 12 suppresses YAP-mediated hepatocarcinogenesis by limiting glycerolipid biosynthesis.
    Cancer Lett Volume: 565 Page(s): 216210
    07/01/2023 Authors: He H; Sugiyama A; Snyder NW; Teneche MG; Liu X; Maner-Smith KM; Goessling W; Hagen SJ; Ortlund EA; Najafi-Shoushtari SH
  • Ligand dependent interaction between PC-TP and PPAR mitigates diet-induced hepatic steatosis in male mice.
    Nat Commun Volume: 14 Page(s): 2748
    05/12/2023 Authors: Druzak SA; Tardelli M; Mays SG; El Bejjani M; Mo X; Maner-Smith KM; Bowen T; Cato ML; Tillman MC; Sugiyama A
  • APOE expression and secretion are modulated by mitochondrial dysfunction.
    Elife Volume: 12
    05/12/2023 Authors: Wynne ME; Ogunbona O; Lane AR; Gokhale A; Zlatic SA; Xu C; Wen Z; Duong DM; Rayaprolu S; Ivanova A
  • Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19.
    Nat Commun Volume: 14 Page(s): 1638
    04/04/2023 Authors: Druzak S; Iffrig E; Roberts BR; Zhang T; Fibben KS; Sakurai Y; Verkerke HP; Rostad CA; Chahroudi A; Schneider F
  • Sensitivity of Rapid Antigen Tests Against SARS-CoV-2 Omicron and Delta Variants.
    medRxiv
    02/10/2023 Authors: Rao A; Westbrook A; Bassit L; Parsons R; Fitts E; Greenleaf M; McLendon K; Sullivan JA; O'Sick W; Baugh T
  • Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.
    bioRxiv
    02/04/2023 Authors: Many GM; Sanford JA; Sagendorf TJ; Hou Z; Nigro P; Whytock K; Amar D; Caputo T; Gay NR; Gaul DA
  • The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits.
    bioRxiv
    01/28/2023 Authors: Mays SG; Hercules D; Ortlund EA; Okafor CD
  • African American Women with Cardiometabolic Complications of Pregnancy Have Decreased Serum Abundance of Specialized Pro-Resolving Lipid Mediators and Endocannabinoids.
    Nutrients Volume: 15
    12/28/2022 Authors: Maner-Smith KM; Ferranti E; Dunlop A; Corwin E; Ortlund EA
  • SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks.
    Nat Commun Volume: 13 Page(s): 6707
    11/07/2022 Authors: Kapoor-Vazirani P; Rath SK; Liu X; Shu Z; Bowen NE; Chen Y; Haji-Seyed-Javadi R; Daddacha W; Minten EV; Danelia D
  • APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
    Nature Volume: 611 Page(s): 769 - 779
    11/01/2022 Authors: Blanchard JW; Akay LA; Davila-Velderrain J; von Maydell D; Mathys H; Davidson SM; Effenberger A; Chen C-Y; Maner-Smith K; Hajjar I
  • Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response.
    bioRxiv
    10/24/2022 Authors: Patel A; Kumar S; Lai L; Chakravarthy C; Valanparambil R; Reddy ES; Gottimukkala K; Bajpai P; Raju DR; Edara VV
  • Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody.
    Sci Adv Volume: 8 Page(s): eadd2032
    10/07/2022 Authors: Kumar S; Patel A; Lai L; Chakravarthy C; Valanparambil R; Reddy ES; Gottimukkala K; Davis-Gardner ME; Edara VV; Linderman S
  • OBESITY-INDUCED ACTIVATION OF Ybx1 PROMOTES ADIPOGENIC AND INFLAMMATORY GENE EXPRESSION WITHIN HEPATOCYTES
    Volume: 76 Page(s): S831 - S831
    10/01/2022 Authors: Jordan JM; Qiao J; Haczeyni F; Maner-Smith KM; Ortlund EA; Ersoy BA
  • COMBINED VIRTUAL AND CHEMICAL HIGH-THROUGHPUT SCREENING IDENTIFIES SMALL MOLECULE INHIBITORS TARGETING THIOESTERASE SUPERFAMILY MEMBER 2 FOR THE MANAGEMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
    Volume: 76 Page(s): S660 - S661
    10/01/2022 Authors: Landzberg RS; Krumm CS; Hare SR; Liu X; Ortlund EA; Cohen DE
  • CATALYTIC ACTIVITY IS REQUIRED FOR THIOESTERASE SUPERFAMILY MEMBER 2 IN SKELETAL MUSCLE TO PROMOTE HEPATIC STEATOSIS AND INSULIN RESISTANCE
    Volume: 76 Page(s): S643 - S643
    10/01/2022 Authors: Xie Y; Liu X; Ortlund EA; Cohen DE
  • Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests.
    Cell Volume: 185 Page(s): 3603 - 3616.e13
    09/15/2022 Authors: Frank F; Keen MM; Rao A; Bassit L; Liu X; Bowers HB; Patel AB; Cato ML; Sullivan JA; Greenleaf M
  • A phospholipid mimetic targeting LRH-1 ameliorates colitis.
    Cell Chem Biol Volume: 29 Page(s): 1174 - 1186.e7
    07/21/2022 Authors: Mays SG; D'Agostino EH; Flynn AR; Huang X; Wang G; Liu X; Millings EJ; Okafor CD; Patel A; Cato ML
  • Lysosome lipid signalling from the periphery to neurons regulates longevity.
    Nat Cell Biol Volume: 24 Page(s): 906 - 916
    06/01/2022 Authors: Savini M; Folick A; Lee Y-T; Jin F; Cuevas A; Tillman MC; Duffy JD; Zhao Q; Neve IA; Hu P-W
  • Don't forget about human factors: Lessons learned from COVID-19 point-of-care testing.
    Cell Rep Methods Volume: 2 Page(s): 100222
    05/23/2022 Authors: Farmer S; Razin V; Peagler AF; Strickler S; Fain WB; Damhorst GL; Kempker RR; Pollock NR; Brand O; Seitter B
  • Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket.
    J Med Chem Volume: 65 Page(s): 6888 - 6902
    05/12/2022 Authors: Cato ML; Cornelison JL; Spurlin RM; Courouble VV; Patel AB; Flynn AR; Johnson AM; Okafor CD; Frank F; D'Agostino EH
  • Development and Characterization of Novel LRH-1 Antagonist Using Structural and Computational Techniques.
    FASEB J Volume: 36 Suppl 1
    05/01/2022 Authors: Cato ML; Spurlin R; Cornelison J; Jui N; Ortlund E
  • Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against native-like vaccine and delta variant spike trimers.
    Res Sq
    02/16/2022 Authors: Cheedarla N; Verkerke HP; Potlapalli S; McLendon KB; Patel A; Frank F; Damhorst GL; Wu H; O'Sick WH; Graciaa D
  • Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against native-like vaccine and delta variant spike trimers.
    medRxiv
    02/02/2022 Authors: Cheedarla N; Verkerke HP; Potlapalli S; McLendon KB; Patel A; Frank F; Damhorst GL; Wu H; O Sick WH; Graciaa D
  • Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity.
    PLoS One Volume: 17 Page(s): e0277053
    01/01/2022 Authors: Heintz MM; Eccles JA; Olack EM; Maner-Smith KM; Ortlund EA; Baldwin WS
  • Age- and Diet-Dependent Changes in Hepatic Lipidomic Profiles of Phospholipids in Male Mice: Age Acceleration in Cyp2b-Null Mice.
    J Lipids Volume: 2022 Page(s): 7122738
    01/01/2022 Authors: Heintz MM; Kumar R; Maner-Smith KM; Ortlund EA; Baldwin WS
  • Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice.
    Hepatology Volume: 75 Page(s): 154 - 169
    01/01/2022 Authors: Imai N; Nicholls HT; Alves-Bezerra M; Li Y; Ivanova AA; Ortlund EA; Cohen DE
  • Microbial metabolite delta-valerobetaine is a diet-dependent obesogen.
    Nat Metab Volume: 3 Page(s): 1694 - 1705
    12/01/2021 Authors: Liu KH; Owens JA; Saeedi B; Cohen CE; Bellissimo MP; Naudin C; Darby T; Druzak S; Maner-Smith K; Orr M
  • Structural insights into glucocorticoid receptor function.
    Biochem Soc Trans Volume: 49 Page(s): 2333 - 2343
    11/01/2021 Authors: Frank F; Ortlund EA; Liu X
  • Ligand-dependent interactions between phosphatidylcholine transfer protein and PPARd: Therapeutic implications for the metabolic syndrome.
    Volume: 30 Page(s): 71 - 72
    10/01/2021 Authors: Druzak S; Tardelli M; Mays S; Cato M; Tillman M; Cohen D; Ortlund E
  • Disruption of a key ligand-H-bond network drives glucocorticoid receptor gene suppression without off-target gene activation
    Volume: 30 Page(s): 23 - 23
    10/01/2021 Authors: Liu X; Hoffman E; Ortlund E
  • Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element.
    Nucleic Acids Res Volume: 49 Page(s): 8923 - 8933
    09/07/2021 Authors: Liu X; Weikum ER; Tilo D; Vinson C; Ortlund EA
  • TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis.
    PLoS Pathog Volume: 17 Page(s): e1009941
    09/01/2021 Authors: Collins JM; Jones DP; Sharma A; Khadka M; Liu KH; Kempker RR; Prideaux B; Maner-Smith K; Tukvadze N; Shah NS
  • Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation.
    Proc Natl Acad Sci U S A Volume: 118
    07/27/2021 Authors: Frank F; Liu X; Ortlund EA
  • Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice.
    Nat Commun Volume: 12 Page(s): 3493
    06/09/2021 Authors: Li Y; Imai N; Nicholls HT; Roberts BR; Goyal S; Krisko TI; Ang L-H; Tillman MC; Roberts AM; Baqai M
  • Targeting Them1 for the Management of Obesity-Related Disorders
    Volume: 35
    05/01/2021 Authors: Krumm C; Ramos-Espiritu L; Adura C; Tillman M; Landzberg R; Glickman JF; Ortlund E; Cohen D
  • Uniting features from strongly activating small molecules to develop chimeric LRH-1 agonist
    Volume: 35
    05/01/2021 Authors: Cato M; Cornelison J; Flynn A; Johnson A; Okafor C; Jui N; Patel A; Frank F; D'Agostino E; Ortlund E
  • Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling.
    Nat Chem Biol Volume: 17 Page(s): 307 - 316
    03/01/2021 Authors: Bruno NE; Nwachukwu JC; Srinivasan S; Nettles CC; Izard T; Jin Z; Nowak J; Cameron MD; Boregowda SV; Phinney DG
  • Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons.
    J Biol Chem Volume: 296 Page(s): 100024
    01/01/2021 Authors: Squires KE; Gerber KJ; Tillman MC; Lustberg DJ; Montaez-Miranda C; Zhao M; Ramineni S; Scharer CD; Saha RN; Shu F-J
  • RADx Variant Task Force Program for Assessing the Impact of Variants on SARS-CoV-2 Molecular and Antigen Tests.
    IEEE Open J Eng Med Biol Volume: 2 Page(s): 286 - 290
    01/01/2021 Authors: Creager R; Blackwood J; Pribyl T; Bassit L; Rao A; Greenleaf M; Frank F; Lam W; Ortlund E; Schinazi R
  • Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist.
    Sci Rep Volume: 10 Page(s): 22279
    12/17/2020 Authors: Mays SG; Stec J; Liu X; D'Agostino EH; Whitby RJ; Ortlund EA
  • Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons.
    J Biol Chem
    11/04/2020 Authors: Squires KE; Gerber KJ; Tillman MC; Lustberg DJ; Montaez-Miranda C; Zhao M; Ramineni S; Scharer CD; Saha RN; Shu F-J
  • The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells.
    Nat Commun Volume: 11 Page(s): 5010
    10/06/2020 Authors: Moody JC; Qadota H; Reedy AR; Okafor CD; Shanmugan N; Matsunaga Y; Christian CJ; Ortlund EA; Benian GM
  • Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment.
    Proc Natl Acad Sci U S A Volume: 117 Page(s): 24285 - 24293
    09/29/2020 Authors: Liu X; Wang Y; Gutierrez JS; Damsker JM; Nagaraju K; Hoffman EP; Ortlund EA
  • Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine.
    Proc Natl Acad Sci U S A Volume: 117 Page(s): 22080 - 22089
    09/08/2020 Authors: Tillman MC; Imai N; Li Y; Khadka M; Okafor CD; Juneja P; Adhiyaman A; Hagen SJ; Cohen DE; Ortlund EA
  • Acyl-Coenzyme A Thioesterase 9 Traffics Mitochondrial Short-Chain Fatty Acids Toward De Novo Lipogenesis and Glucose Production in the Liver.
    Hepatology Volume: 72 Page(s): 857 - 872
    09/01/2020 Authors: Steensels S; Qiao J; Zhang Y; Maner-Smith KM; Kika N; Holman CD; Corey KE; Bracken WC; Ortlund EA; Ersoy BA
  • A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird.
    Proc Natl Acad Sci U S A Volume: 117 Page(s): 21673 - 21680
    09/01/2020 Authors: Merritt JR; Grogan KE; Zinzow-Kramer WM; Sun D; Ortlund EA; Yi SV; Maney DL
  • Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition.
    Bioorg Med Chem Lett Volume: 30 Page(s): 127293
    08/15/2020 Authors: Cornelison JL; Cato ML; Johnson AM; D'Agostino EH; Melchers D; Patel AB; Mays SG; Houtman R; Ortlund EA; Jui NT
  • Lactococcus lactis Subspecies cremoris Elicits Protection Against Metabolic Changes Induced by a Western-Style Diet.
    Gastroenterology Volume: 159 Page(s): 639 - 651.e5
    08/01/2020 Authors: Naudin CR; Maner-Smith K; Owens JA; Wynn GM; Robinson BS; Matthews JD; Reedy AR; Luo L; Wolfarth AA; Darby TM
  • Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination.
    Vaccines (Basel) Volume: 8
    07/24/2020 Authors: Maner-Smith KM; Goll JB; Khadka M; Jensen TL; Colucci JK; Gelber CE; Albert CJ; Bosinger SE; Franke JD; Natrajan M
  • The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions.
    Cell Rep Volume: 32 Page(s): 107933
    07/21/2020 Authors: Frank F; Kavousi N; Bountali A; Dammer EB; Mourtada-Maarabouni M; Ortlund EA
  • Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.
    Cell Volume: 181 Page(s): 1464 - 1474
    06/25/2020 Authors: Sanford JA; Nogiec CD; Lindholm ME; Adkins JN; Amar D; Dasari S; Drugan JK; Fernndez FM; Radom-Aizik S; Schenk S
  • Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients.
    Cell Rep Med Volume: 1 Page(s): 100040
    06/23/2020 Authors: Suthar MS; Zimmerman MG; Kauffman RC; Mantus G; Linderman SL; Hudson WH; Vanderheiden A; Nyhoff L; Davis CW; Adekunle O
  • Rapid generation of neutralizing antibody responses in COVID-19 patients.
    medRxiv
    05/08/2020 Authors: Suthar MS; Zimmerman M; Kauffman R; Mantus G; Linderman S; Vanderheiden A; Nyhoff L; Davis C; Adekunle S; Affer M
  • Interleukin-13 drives metabolic conditioning of muscle to endurance exercise.
    Science Volume: 368
    05/01/2020 Authors: Knudsen NH; Stanya KJ; Hyde AL; Chalom MM; Alexander RK; Liou Y-H; Starost KA; Gangl MR; Jacobi D; Liu S
  • Fragment-Based Screening to Identify Thioesterase Superfamily Member 2 (Them2) Inhibitors for the Management of Obesity-Related Disorders
    Volume: 34
    04/01/2020 Authors: Krumm C; Adura C; Liu X; Li Y; Bracken W; Ginn J; Glickman J; Ortlund E; Cohen D
  • Development of picomolar liver receptor homolog-1 agonist
    Volume: 34
    04/01/2020 Authors: Cato M; Cornelison J; Flynn A; D'Agostino E; Jui N; Ortlund E
  • Thioesterase Superfamily Member 1 Undergoes Stimulus-coupled Reorganization to Regulate Metabolic Activity in Brown Adipose Tissue
    Volume: 34
    04/01/2020 Authors: Li Y; Imai N; Goyal S; Nicholls H; Krisko T; Baqai M; Ang L-H; Tillman M; Ortlund E; Cohen D
  • The Them1 START Domain Regulates Nuclear Trafficking in Brown Adipocytes
    Volume: 34
    04/01/2020 Authors: Baqai M; Li Y; Tillman M; Ortlund E; Cohen D; Hagen S
  • Them1 Binds to Free Fatty Acids and is Allosterically Regulated by Lysophosphatidylcholine to Control Fatty Acyl-CoA Hydrolysis in Brown Adipose Tissue
    Volume: 34
    04/01/2020 Authors: Tillman M; Li Y; Khadka M; Imai N; Adhiyaman A; Juneja P; Hagen S; Cohen D; Ortlund E
  • Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors.
    ACS Med Chem Lett Volume: 11 Page(s): 365 - 370
    03/12/2020 Authors: D'Agostino EH; Flynn AR; Cornelison JL; Mays SG; Patel A; Jui NT; Ortlund EA
  • Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors.
    Structure Volume: 28 Page(s): 196 - 205.e3
    02/04/2020 Authors: Okafor CD; Hercules D; Kell SA; Ortlund EA
  • Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis.
    Cell Mol Gastroenterol Hepatol Volume: 10 Page(s): 713 - 727
    01/01/2020 Authors: Wolfarth AA; Liu X; Darby TM; Boyer DJ; Spizman JB; Owens JA; Chandrasekharan B; Naudin CR; Hanley KZ; Robinson BS
  • Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.
    J Med Chem Volume: 62 Page(s): 11022 - 11034
    12/26/2019 Authors: Mays SG; Flynn AR; Cornelison JL; Okafor CD; Wang H; Wang G; Huang X; Donaldson HN; Millings EJ; Polavarapu R
  • First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-Activated Coactivator 1- Complex with Endogenous and Synthetic Glucocorticoids.
    Mol Pharmacol Volume: 96 Page(s): 408 - 417
    10/01/2019 Authors: Liu X; Wang Y; Ortlund EA
  • Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids Into Triglyceride Biosynthesis.
    Hepatology Volume: 70 Page(s): 496 - 510
    08/01/2019 Authors: Alves-Bezerra M; Li Y; Acua M; Ivanova AA; Corey KE; Ortlund EA; Cohen DE
  • Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8.
    Sci Rep Volume: 9 Page(s): 9966
    07/10/2019 Authors: Tillman MC; Khadka M; Duffy J; Wang MC; Ortlund EA
  • The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry.
    Biomolecules Volume: 9
    05/23/2019 Authors: Khadka M; Todor A; Maner-Smith KM; Colucci JK; Tran V; Gaul DA; Anderson EJ; Natrajan MS; Rouphael N; Mulligan MJ
  • Distinct amino acid and lipid perturbations characterize acute versus chronic malaria.
    JCI Insight Volume: 4
    05/02/2019 Authors: Cordy RJ; Patrapuvich R; Lili LN; Cabrera-Mora M; Chien J-T; Tharp GK; Khadka M; Meyer EV; Lapp SA; Joyner CJ
  • Development of a Robust Direct Binding Assay for Phospholipid-Sensing NR5A Receptors
    Volume: 33
    04/01/2019 Authors: D'Agostino EH; Cornelison J; Mays S; Flynn A; Jui N; Ortlund E
  • Fatty Acids Bind to Theml, a Negative Regulator of Thermogenesis in Brown Adipose Tissue
    Volume: 33
    04/01/2019 Authors: Tillman MC; Khadka M; Okafor CD; Juneja PC; Ortlund EA
  • The Allosteric Mechanisms Driving the Evolution of Androgen Specificity
    Volume: 27 Page(s): 148 - 148
    11/01/2018 Authors: Okafor D; Colucci J; Ortlund E
  • Structure and Inhibition of Them2, An Acyl-Coa Thioesterase that Controls Hepatic Glucose and Lipid Metabolism
    Volume: 27 Page(s): 188 - 189
    11/01/2018 Authors: Liu X; Tillander V; Cohen D; Ortlund E
  • The nuclear receptor superfamily: A structural perspective.
    Protein Sci Volume: 27 Page(s): 1876 - 1892
    11/01/2018 Authors: Weikum ER; Liu X; Ortlund EA
  • Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1.
    ACS Med Chem Lett Volume: 9 Page(s): 1051 - 1056
    10/11/2018 Authors: Flynn AR; Mays SG; Ortlund EA; Jui NT
  • Delimiting the autoinhibitory module of von Willebrand factor.
    J Thromb Haemost Volume: 16 Page(s): 2097 - 2105
    10/01/2018 Authors: Deng W; Voos KM; Colucci JK; Legan ER; Ortlund EA; Lollar P; Li R
  • The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor.
    Sci Rep Volume: 8 Page(s): 13497
    09/10/2018 Authors: Frank F; Okafor CD; Ortlund EA
  • The allosteric mechanisms driving the evolution of androgen specificity
    Volume: 256
    08/19/2018 Authors: Okafor C; Colucci J; Ortlund E
  • Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
    Immunity Volume: 49 Page(s): 42 - 55.e6
    07/17/2018 Authors: Mandal P; Feng Y; Lyons JD; Berger SB; Otani S; DeLaney A; Tharp GK; Maner-Smith K; Burd EM; Schaeffer M
  • Cryptic glucocorticoid receptor-binding sites pervade genomic NF-B response elements.
    Nat Commun Volume: 9 Page(s): 1337
    04/06/2018 Authors: Hudson WH; Vera IMSD; Nwachukwu JC; Weikum ER; Herbst AG; Yang Q; Bain DL; Nettles KW; Kojetin DJ; Ortlund EA
  • Fatty Acids Bind to the StAR-Related Lipid Transfer Domain of Thioesterase Superfamily Member 1, a Master Regulator of Thermogenesis and Energy Expenditure
    Volume: 32
    04/01/2018 Authors: Tillman MC; Ortlund E
  • Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.
    Structure Volume: 26 Page(s): 118 - 129.e3
    01/02/2018 Authors: Okafor CD; Pathak MC; Fagan CE; Bauer NC; Cole MF; Gaucher EA; Ortlund EA
  • High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans.
    PLoS One Volume: 13 Page(s): e0205398
    01/01/2018 Authors: Collins JM; Walker DI; Jones DP; Tukvadze N; Liu KH; Tran VT; Uppal K; Frediani JK; Easley KA; Shenvi N
  • Elucidating the Mechanism of Lipid Binding Protein 8 Shuttling of Lysosomal Lipids into the Nucleus in Caenorhabditis Elegans
    Volume: 26 Page(s): 185 - 185
    12/01/2017 Authors: Tillman M; Wang M; Ortlund E
  • Nucleotide Binding to ARL2 in the TBCDARL2-Tubulin Complex Drives Conformational Changes in -Tubulin.
    J Mol Biol Volume: 429 Page(s): 3696 - 3716
    11/24/2017 Authors: Francis JW; Goswami D; Novick SJ; Pascal BD; Weikum ER; Ortlund EA; Griffin PR; Kahn RA
  • Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.
    Nucleic Acids Res Volume: 45 Page(s): 8596 - 8608
    08/21/2017 Authors: Weikum ER; de Vera IMS; Nwachukwu JC; Hudson WH; Nettles KW; Kojetin DJ; Ortlund EA
  • Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner.
    Mol Pharmacol Volume: 92 Page(s): 12 - 21
    07/01/2017 Authors: Weikum ER; Okafor CD; D'Agostino EH; Colucci JK; Ortlund EA
  • Structure and Dynamics of the Liver Receptor Homolog 1-PGC1 Complex.
    Mol Pharmacol Volume: 92 Page(s): 1 - 11
    07/01/2017 Authors: Mays SG; Okafor CD; Tuntland ML; Whitby RJ; Dharmarajan V; Stec J; Griffin PR; Ortlund EA
  • Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation
    Volume: 31
    04/01/2017 Authors: Okafor D; Mays SC; Whitby RJ; Goswami D; Stec J; Flynn AR; Dugan MC; Jui N; Griffin P; Ortlund E
  • An estrogen receptor alpha polymorphism may mediate behavioral polymorphism in the white-throated sparrow
    Volume: 57 Page(s): E348 - E348
    03/01/2017 Authors: Merritt JR; Mays SG; Ortlund EA; Maney DL
  • Glucocorticoid receptor control of transcription: precision and plasticity via allostery.
    Nat Rev Mol Cell Biol Volume: 18 Page(s): 159 - 174
    03/01/2017 Authors: Weikum ER; Knuesel MT; Ortlund EA; Yamamoto KR
  • Elucidating the Mechanism of LBP-8 Shuttling of Lysosomal Lipids into the Nucleus in C. elegans
    Volume: 73 Page(s): A106 - A106
    01/01/2017 Authors: Tillman M; Wang M; Ortlund E
  • THE ROLE OF SOLUBLE LIPID TRANSPORT PROTEINS IN MODULATING LIVER RECEPTOR HOMOLOG-1 (LRH-1) MEDIATED GENE EXPRESSION
    Volume: 88 Page(s): 34 - 35
    01/01/2017 Authors: El Bejjani M; Mays SG; Tillman MC; Ortlund EA
  • Targeting the Nuclear Receptor LRH-1 with Synthetic Agonists
    Volume: 73 Page(s): A98 - A98
    01/01/2017 Authors: Mays SG; Okafor CD; Whitby R; Goswami D; Stec J; Flynn A; Dugan M; Jui N; Griffin P; Ortlund EA
  • A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).
    J Mol Biol Volume: 428 Page(s): 4981 - 4992
    12/04/2016 Authors: Weikum ER; Tuntland ML; Murphy MN; Ortlund EA
  • Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.
    J Biol Chem Volume: 291 Page(s): 25281 - 25291
    12/02/2016 Authors: Mays SG; Okafor CD; Whitby RJ; Goswami D; Stec J; Flynn AR; Dugan MC; Jui NT; Griffin PR; Ortlund EA
  • Biophysical mechanisms driving the evolution of androgen specificity
    Volume: 25 Page(s): 100 - 100
    10/01/2016 Authors: Okafor D; Colucci J; Ortlund E
  • Untethering glucocorticoid receptor-mediated transcriptional repression
    Volume: 30
    04/01/2016 Authors: Weikum ER; Hudson W; Ortlund E
  • Untethering glucocorticoid receptor-mediated transcriptional repression
    Volume: 30
    04/01/2016 Authors: Weikum ER; Hudson W; Ortlund E
  • Evolving allostery of the 3-ketosteroid family of nuclear receptors
    Volume: 251
    03/13/2016 Authors: Kossmann B; Hudson W; Ivanov I; Ortlund E
  • Computational discovery of activating and repressing states for the liver receptor homologue 1 ligand binding domain
    Volume: 251
    03/13/2016 Authors: Kossmann B; Musille P; Ivanov I; Ortlund E
  • Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.
    J Biol Chem Volume: 291 Page(s): 1411 - 1426
    01/15/2016 Authors: Musille PM; Kossmann BR; Kohn JA; Ivanov I; Ortlund EA
  • Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
    Proc Natl Acad Sci U S A Volume: 113 Page(s): 326 - 331
    01/12/2016 Authors: Hudson WH; Kossmann BR; de Vera IMS; Chuo S-W; Weikum ER; Eick GN; Thornton JW; Ivanov IN; Kojetin DJ; Ortlund EA
  • Identification of a lipid scrambling domain in ANO6/TMEM16F.
    Elife Volume: 4 Page(s): e06901
    06/09/2015 Authors: Yu K; Whitlock JM; Lee K; Ortlund EA; Cui YY; Hartzell HC
  • Integration of G protein (G) signaling by the regulator of G protein signaling 14 (RGS14).
    J Biol Chem Volume: 290 Page(s): 9037 - 9049
    04/03/2015 Authors: Brown NE; Goswami D; Branch MR; Ramineni S; Ortlund EA; Griffin PR; Hepler JR
  • Untethering Glucocorticoid Receptor-Mediated Transcriptional Repression of Inflammatory Genes
    Volume: 29
    04/01/2015 Authors: Rye E; Ortlund E
  • Evolution of Novel Response Element Specificity in the Glucocorticoid Receptor
    Volume: 29
    04/01/2015 Authors: Hudson W; Ortlund E
  • An Allosteric Network in LRH-1 Mediates Phospholipid-Driven Gene Regulation
    Volume: 29
    04/01/2015 Authors: Kohn J; Musille P; Kossmann B; Ivanov I; Ortlund E
  • Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.
    Science Volume: 347 Page(s): 83 - 86
    01/02/2015 Authors: Folick A; Oakley HD; Yu Y; Armstrong EH; Kumari M; Sanor L; Moore DD; Ortlund EA; Zechner R; Wang MC
  • Evolution of novel response element specificity in the glucocorticoid receptor
    Volume: 25
    12/01/2014 Authors: Hudson WH; Ortlund EA
  • Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.
    Nat Commun Volume: 5 Page(s): 5395
    11/07/2014 Authors: Hudson WH; Pickard MR; de Vera IMS; Kuiper EG; Mourtada-Maarabouni M; Conn GL; Kojetin DJ; Williams GT; Ortlund EA
  • The structure, function and evolution of proteins that bind DNA and RNA.
    Nat Rev Mol Cell Biol Volume: 15 Page(s): 749 - 760
    11/01/2014 Authors: Hudson WH; Ortlund EA
  • Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
    Cell Volume: 159 Page(s): 58 - 68
    09/25/2014 Authors: McKeown AN; Bridgham JT; Anderson DW; Murphy MN; Ortlund EA; Thornton JW
  • Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor / (FABP5-PPAR/) signaling pathway.
    J Biol Chem Volume: 289 Page(s): 14941 - 14954
    05/23/2014 Authors: Armstrong EH; Goswami D; Griffin PR; Noy N; Ortlund EA
  • Identification of a small molecular insulin receptor agonist with potent antidiabetes activity.
    Diabetes Volume: 63 Page(s): 1394 - 1409
    04/01/2014 Authors: Qiang G; Xue S; Yang JJ; Du G; Pang X; Li X; Goswami D; Griffin PR; Ortlund EA; Chan CB
  • Evolutionary history and metabolic insights of ancient mammalian uricases.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): 3763 - 3768
    03/11/2014 Authors: Kratzer JT; Lanaspa MA; Murphy MN; Cicerchi C; Graves CL; Tipton PA; Ortlund EA; Johnson RJ; Gaucher EA
  • A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis.
    Mol Biol Cell Volume: 25 Page(s): 712 - 727
    03/01/2014 Authors: Ren J; Pei-Chen Lin C; Pathak MC; Temple BRS; Nile AH; Mousley CJ; Duncan MC; Eckert DM; Leiker TJ; Ivanova PT
  • Structure of glycerol dehydrogenase from Serratia.
    Acta Crystallogr F Struct Biol Commun Volume: 70 Page(s): 166 - 172
    02/01/2014 Authors: Musille P; Ortlund E
  • Estrogen receptor polymorphism in a species with alternative behavioral phenotypes.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): 1443 - 1448
    01/28/2014 Authors: Horton BM; Hudson WH; Ortlund EA; Shirk S; Thomas JW; Young ER; Zinzow-Kramer WM; Maney DL
  • Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.
    PLoS One Volume: 9 Page(s): e107000
    01/01/2014 Authors: Hudson WH; Youn C; Ortlund EA
  • Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.
    PLoS Genet Volume: 10 Page(s): e1004058
    01/01/2014 Authors: Bridgham JT; Keay J; Ortlund EA; Thornton JW
  • Expression, purification and crystallization of the ancestral androgen receptor-DHT complex.
    Acta Crystallogr Sect F Struct Biol Cryst Commun Volume: 69 Page(s): 994 - 996
    09/01/2013 Authors: Colucci JK; Ortlund EA
  • Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors.
    J Biol Chem Volume: 288 Page(s): 20702 - 20712
    07/12/2013 Authors: Musille PM; Pathak M; Lauer JL; Griffin PR; Ortlund EA
  • Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.
    Proc Natl Acad Sci U S A Volume: 110 Page(s): 11475 - 11480
    07/09/2013 Authors: Harms MJ; Eick GN; Goswami D; Colucci JK; Griffin PR; Ortlund EA; Thornton JW
  • Phospholipid--driven gene regulation.
    FEBS Lett Volume: 587 Page(s): 1238 - 1246
    04/17/2013 Authors: Musille PM; Kohn JA; Ortlund EA
  • Hydrophobic environment is a key factor for the stability of thermophilic proteins.
    Proteins Volume: 81 Page(s): 715 - 721
    04/01/2013 Authors: Gromiha MM; Pathak MC; Saraboji K; Ortlund EA; Gaucher EA
  • X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface.
    PLoS One Volume: 8 Page(s): e80761
    01/01/2013 Authors: Colucci JK; Ortlund EA
  • The structural basis of direct glucocorticoid-mediated transrepression.
    Nat Struct Mol Biol Volume: 20 Page(s): 53 - 58
    01/01/2013 Authors: Hudson WH; Youn C; Ortlund EA
  • Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation.
    ChemMedChem Volume: 7 Page(s): 1909 - 1914
    11/01/2012 Authors: Rey J; Hu H; Kyle F; Lai C-F; Buluwela L; Coombes RC; Ortlund EA; Ali S; Snyder JP; Barrett AGM
  • Deciphering modern glucocorticoid cross-pharmacology using ancestral corticosteroid receptors
    Volume: 21 Page(s): 168 - 168
    08/01/2012 Authors: Kohn J; Deshpande K; Ortlund E
  • Evolution of Ligand Specificity in Steroid Hormone Nuclear Receptors
    Volume: 21 Page(s): 87 - 87
    08/01/2012 Authors: Colucci J; Ortlund E
  • Deciphering modern glucocorticoid cross-pharmacology using ancestral corticosteroid receptors.
    J Biol Chem Volume: 287 Page(s): 16267 - 16275
    05/11/2012 Authors: Kohn JA; Deshpande K; Ortlund EA
  • Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.
    Nat Struct Mol Biol Volume: 19 Page(s): 532 - 5S2
    04/15/2012 Authors: Musille PM; Pathak M; Lauer JL; Hudson WH; Griffin PR; Ortlund EA
  • Evolution of minimal specificity and promiscuity in steroid hormone receptors.
    PLoS Genet Volume: 8 Page(s): e1003072
    01/01/2012 Authors: Eick GN; Colucci JK; Harms MJ; Ortlund EA; Thornton JW
  • Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily.
    Acta Crystallogr Sect F Struct Biol Cryst Commun Volume: 67 Page(s): 1239 - 1243
    10/01/2011 Authors: Ren J; Schaaf G; Bankaitis VA; Ortlund EA; Pathak MC
  • The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells.
    Breast Cancer Res Treat Volume: 127 Page(s): 385 - 396
    06/01/2011 Authors: Thiruchelvam PTR; Lai C-F; Hua H; Thomas RS; Hurtado A; Hudson W; Bayly AR; Kyle FJ; Periyasamy M; Photiou A
  • Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor.
    PLoS Genet Volume: 7 Page(s): e1002117
    06/01/2011 Authors: Carroll SM; Ortlund EA; Thornton JW
  • A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.
    Nature Volume: 474 Page(s): 506 - 510
    05/25/2011 Authors: Lee JM; Lee YK; Mamrosh JL; Busby SA; Griffin PR; Pathak MC; Ortlund EA; Moore DD
  • Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution.
    Mol Biol Cell Volume: 22 Page(s): 892 - 905
    03/15/2011 Authors: Schaaf G; Dynowski M; Mousley CJ; Shah SD; Yuan P; Winklbauer EM; de Campos MKF; Trettin K; Quinones M-C; Smirnova TI
  • Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor.
    PLoS Biol Volume: 8
    10/05/2010 Authors: Bridgham JT; Eick GN; Larroux C; Deshpande K; Harms MJ; Gauthier MEA; Ortlund EA; Degnan BM; Thornton JW
  • Molecular Evolution of Mineralocorticoid Receptor - Hormone Interactions
    Volume: 50 Page(s): E17 - E17
    07/01/2010 Authors: Bridgham JT; Ortlund EA; Thornton JW
  • Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection.
    Proc Natl Acad Sci U S A Volume: 107 Page(s): 1948 - 1953
    02/02/2010 Authors: Chen F; Gaucher EA; Leal NA; Hutter D; Havemann SA; Govindarajan S; Ortlund EA; Benner SA
  • An epistatic ratchet constrains the direction of glucocorticoid receptor evolution.
    Nature Volume: 461 Page(s): 515 - 519
    09/24/2009 Authors: Bridgham JT; Ortlund EA; Thornton JW
  • Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily.
    Mol Cell Volume: 29 Page(s): 191 - 206
    02/01/2008 Authors: Schaaf G; Ortlund EA; Tyeryar KR; Mousley CJ; Ile KE; Garrett TA; Ren J; Woolls MJ; Raetz CRH; Redinbo MR
  • Crystal structure of an ancient protein: evolution by conformational epistasis.
    Science Volume: 317 Page(s): 1544 - 1548
    09/14/2007 Authors: Ortlund EA; Bridgham JT; Redinbo MR; Thornton JW
  • Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family.
    Biochim Biophys Acta Volume: 1774 Page(s): 637 - 644
    05/01/2007 Authors: Chiswell B; Lovelace LL; Brannen C; Ortlund EA; Lebioda L; Sodetz JM
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.
    J Mol Biol Volume: 354 Page(s): 1091 - 1102
    12/16/2005 Authors: Solomon IH; Hager JM; Safi R; McDonnell DP; Redinbo MR; Ortlund EA
  • Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.
    Nat Struct Mol Biol Volume: 12 Page(s): 357 - 363
    04/01/2005 Authors: Ortlund EA; Lee Y; Solomon IH; Hager JM; Safi R; Choi Y; Guan Z; Tripathy A; Raetz CRH; McDonnell DP
  • Crystal structure of a covalent intermediate of endogenous human arylsulfatase A.
    J Inorg Biochem Volume: 96 Page(s): 386 - 392
    08/01/2003 Authors: Chruszcz M; Laidler P; Monkiewicz M; Ortlund E; Lebioda L; Lewinski K
  • Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design.
    Biochemistry Volume: 42 Page(s): 383 - 389
    01/21/2003 Authors: Ortlund E; LaCount MW; Lebioda L
  • Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site.
    Biochemistry Volume: 41 Page(s): 7030 - 7037
    06/04/2002 Authors: Ortlund E; Parker CL; Schreck SF; Ginell S; Minor W; Sodetz JM; Lebioda L
  • Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu.
    Biochemistry Volume: 39 Page(s): 1199 - 1204
    02/15/2000 Authors: Ortlund E; Lacount MW; Lewinski K; Lebioda L
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