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Profile

Erin Scherer

  • Department of Medicine
    Assistant Professor
  • (404) 712-6904
  • erin.margaret.scherer@emory.edu
  • Emory University
    Hope Clinic
    500 Irvin Ct., Ste 200
Head shot of Erin Scherer

Overview

My independent research focuses on understanding the immune mechanisms that underlie durable and protective B cell/antibody responses in order to more reliably design infectious disease vaccines that provide life-long immunity.

Academic Appointment

  • Assistant Professor, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University
  • Director, Hope Clinic Vaccine and Treatment Evaluation Unit (VTEU) Research Laboratory, Hope Clinic, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University

Education

Degrees

  • DPhil from University of Oxford
  • PhD from Scripps Research Institute
  • BS from University of Arkansas at Fayetteville

Research

Publications

  • Corrigendum to "Long-Term immune memory responses to human papillomavirus (HPV) vaccination following 2 versus 3 doses of HPV vaccine" [Vaccine, Volume 50, 19 March 2025, 126,817].
    Vaccine Volume: 54 Page(s): 126974
    04/30/2025 Authors: Carter JJ; Smith RA; Scherer EM; Skibinski DAG; Sankaranarayanan S; Luxembourg A; Kollmann T; Marty KD; Sadarangani M; Dobson S
  • Postnatal Zika and Dengue Infection and their Effects on Neurodevelopment Among Children Living in Rural Guatemala.
    Pediatr Infect Dis J Volume: 44 Page(s): 290 - 298
    04/01/2025 Authors: Asturias EJ; Connery AK; Olson D; Lamb MM; Paniagua-Avila A; Anderson EJ; Focht C; Colbert AM; Natrajan M; Waggoner JJ
  • Term immune memory responses to human papillomavirus (HPV) vaccination following 2 versus 3 doses of HPV vaccine.
    Vaccine Volume: 50 Page(s): 126817
    03/19/2025 Authors: Carter JJ; Smith RA; Scherer EM; Skibinski DAG; Sankaranarayanan S; Luxembourg A; Kollmann T; Marty KD; Sadarangani M; Dobson S
  • Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients.
    Nat Commun Volume: 16 Page(s): 586
    01/10/2025 Authors: Pickering H; Schaenman J; Phan HV; Maguire C; Tsitsiklis A; Rouphael N; Higuita NIA; Atkinson MA; Brakenridge S; Fung M
  • Safety and immunogenicity of a ChAd155-vectored rabies vaccine compared with inactivated, purified chick embryo cell rabies vaccine in healthy adults.
    Vaccine Volume: 42 Page(s): 126441
    12/02/2024 Authors: Phadke VK; Gromer DJ; Rebolledo PA; Graciaa DS; Wiley Z; Sherman AC; Scherer EM; Leary M; Girmay T; McCullough MP
  • A Phase 1, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Safety and Immunogenicity of HEV-239 (Hecolin) Vaccine in Healthy US Adults.
    J Infect Dis Volume: 230 Page(s): 1093 - 1101
    11/15/2024 Authors: Kao CM; Rostad CA; Nolan LE; Peters E; Kleinhenz J; Sherman JD; Tippett A; Shih JWK; Yildirim I; Agbakoba V
  • Altered Spike Immunoglobulin G Fc N-Linked Glycans Are Associated With Hyperinflammatory State in Adult Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome in Children.
    Open Forum Infect Dis Volume: 11 Page(s): ofae626
    11/01/2024 Authors: Sherman JD; Karmali V; Kumar B; Simon TW; Bechnak S; Panjwani A; Ciric CR; Wang D; Huerta C; Johnson B
  • Altered spike IgG Fc N-linked glycans are associated with hyperinflammatory state in adult COVID and Multisystem Inflammatory Syndrome in Children.
    medRxiv
    07/14/2024 Authors: Sherman JD; Karmali V; Kumar B; Simon TW; Bechnak S; Panjwani A; Ciric CR; Wang D; Huerta C; Johnson B
  • IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition.
    Nat Commun Volume: 15 Page(s): 404
    01/09/2024 Authors: Haslund-Gourley BS; Woloszczuk K; Hou J; Connors J; Cusimano G; Bell M; Taramangalam B; Fourati S; Mege N; Bernui M
  • Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.
    Nat Commun Volume: 15 Page(s): 216
    01/03/2024 Authors: Ozonoff A; Jayavelu ND; Liu S; Melamed E; Milliren CE; Qi J; Geng LN; McComsey GA; Cairns CB; Baden LR
  • Relationship of Heterologous Virus Responses and Outcomes in Hospitalized COVID-19 Patients.
    J Immunol Volume: 211 Page(s): 1224 - 1231
    10/15/2023 Authors: Rosenberg-Hasson Y; Holmes TH; Diray-Arce J; Chen J; Kellogg R; Snyder M; Becker PM; Ozonoff A; Rouphael N; Reed EF
  • Efficacy and Durability of Immune Response after Receipt of HPV Vaccines in People Living with HIV.
    Vaccines (Basel) Volume: 11
    06/05/2023 Authors: Losada C; Samaha H; Scherer EM; Kazzi B; Khalil L; Ofotokun I; Rouphael N
  • The Coronavirus Disease 2019 Pandemic Unmasked the Challenges Faced by Early-Stage Faculty in Infectious Diseases: A Call to Action.
    Clin Infect Dis Volume: 76 Page(s): 753 - 759
    02/18/2023 Authors: Scherer EM; Backer M; Carvajal K; Danziger-Isakov L; Frey S; Howard LM; Scaggs Huang F; Kottkamp AC; Reid T; Rodriguez-Barradas MC
  • Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study.
    EBioMedicine Volume: 83 Page(s): 104208
    09/01/2022 Authors: Ozonoff A; Schaenman J; Jayavelu ND; Milliren CE; Calfee CS; Cairns CB; Kraft M; Baden LR; Shaw AC; Krammer F
  • SARS-CoV-2 Evolution and Immune Escape in Immunocompromised Patients.
    N Engl J Med Volume: 386 Page(s): 2436 - 2438
    06/23/2022 Authors: Scherer EM; Babiker A; Adelman MW; Allman B; Key A; Kleinhenz JM; Langsjoen RM; Nguyen P-V; Onyechi I; Sherman JD
  • Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase.
    N Engl J Med Volume: 385 Page(s): 1774 - 1785
    11/04/2021 Authors: El Sahly HM; Baden LR; Essink B; Doblecki-Lewis S; Martin JM; Anderson EJ; Campbell TB; Clark J; Jackson LA; Fichtenbaum CJ
  • Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants.
    Science Volume: 373 Page(s): 1372 - 1377
    09/17/2021 Authors: Pegu A; O'Connell SE; Schmidt SD; O'Dell S; Talana CA; Lai L; Albert J; Anderson E; Bennett H; Corbett KS
  • Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19.
    N Engl J Med Volume: 384 Page(s): 2259 - 2261
    06/10/2021 Authors: Doria-Rose N; Suthar MS; Makowski M; O'Connell S; McDermott AB; Flach B; Ledgerwood JE; Mascola JR; Graham BS; Lin BC
  • Evaluation of Cellular and Serological Responses to Acute SARS-CoV-2 Infection Demonstrates the Functional Importance of the Receptor-Binding Domain.
    J Immunol Volume: 206 Page(s): 2605 - 2613
    06/01/2021 Authors: Mantus G; Nyhoff LE; Kauffman RC; Edara VV; Lai L; Floyd K; Shi P-Y; Menachery VD; Edupuganti S; Scherer EM
  • Serotype-Switch Variant of Multidrug-Resistant Streptococcus pneumoniae Sequence Type 271.
    Emerg Infect Dis Volume: 27 Page(s): 1689 - 1692
    06/01/2021 Authors: Scherer EM; Beall B; Metcalf B
  • Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination.
    N Engl J Med Volume: 384 Page(s): 80 - 82
    01/07/2021 Authors: Widge AT; Rouphael NG; Jackson LA; Anderson EJ; Roberts PC; Makhene M; Chappell JD; Denison MR; Stevens LJ; Pruijssers AJ
  • Generation of a cost-effective cell line for support of high-throughput isolation of primary human B cells and monoclonal neutralizing antibodies.
    J Immunol Methods Volume: 488 Page(s): 112901
    01/01/2021 Authors: Whaley RE; Ameny S; Arkatkar T; Seese A; Wall A; Khan I; Carter JJ; Scherer EM; Rawlings DJ; Galloway DA
  • Application of SARS-CoV-2 Serology to Address Public Health Priorities.
    Front Public Health Volume: 9 Page(s): 744535
    01/01/2021 Authors: Sherman AC; Smith T; Zhu Y; Taibl K; Howard-Anderson J; Landay T; Pisanic N; Kleinhenz J; Simon TW; Espinoza D
  • Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults.
    N Engl J Med Volume: 383 Page(s): 2427 - 2438
    12/17/2020 Authors: Anderson EJ; Rouphael NG; Widge AT; Jackson LA; Roberts PC; Makhene M; Chappell JD; Denison MR; Stevens LJ; Pruijssers AJ
  • An mRNA Vaccine against SARS-CoV-2 - Preliminary Report.
    N Engl J Med Volume: 383 Page(s): 1920 - 1931
    11/12/2020 Authors: Jackson LA; Anderson EJ; Rouphael NG; Roberts PC; Makhene M; Coler RN; McCullough MP; Chappell JD; Denison MR; Stevens LJ
  • Remdesivir for the Treatment of Covid-19 - Final Report.
    N Engl J Med Volume: 383 Page(s): 1813 - 1826
    11/05/2020 Authors: Beigel JH; Tomashek KM; Dodd LE; Mehta AK; Zingman BS; Kalil AC; Hohmann E; Chu HY; Luetkemeyer A; Kline S
  • Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients.
    Cell Rep Med Volume: 1 Page(s): 100040
    06/23/2020 Authors: Suthar MS; Zimmerman MG; Kauffman RC; Mantus G; Linderman SL; Hudson WH; Vanderheiden A; Nyhoff L; Davis CW; Adekunle O
  • The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients.
    Sci Immunol Volume: 5
    06/11/2020 Authors: Premkumar L; Segovia-Chumbez B; Jadi R; Martinez DR; Raut R; Markmann A; Cornaby C; Bartelt L; Weiss S; Park Y
  • The RBD Of The Spike Protein Of SARS-Group Coronaviruses Is A Highly Specific Target Of SARS-CoV-2 Antibodies But Not Other Pathogenic Human and Animal Coronavirus Antibodies.
    medRxiv
    05/10/2020 Authors: Premkumar L; Segovia-Chumbez B; Jadi R; Martinez DR; Raut R; Markmann A; Cornaby C; Bartelt L; Weiss S; Park Y
  • Rapid generation of neutralizing antibody responses in COVID-19 patients.
    medRxiv
    05/08/2020 Authors: Suthar MS; Zimmerman M; Kauffman R; Mantus G; Linderman S; Vanderheiden A; Nyhoff L; Davis C; Adekunle S; Affer M
  • Analysis of Memory B-Cell Responses Reveals Suboptimal Dosing Schedule of a Licensed Vaccine.
    J Infect Dis Volume: 217 Page(s): 572 - 580
    01/30/2018 Authors: Scherer EM; Smith RA; Carter JJ; Wipf GC; Gallego DF; Stern M; Wald A; Galloway DA
  • Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
    PLoS Pathog Volume: 12 Page(s): e1005815
    08/01/2016 Authors: Jardine JG; Sok D; Julien J-P; Briney B; Sarkar A; Liang C-H; Scherer EA; Henry Dunand CJ; Adachi Y; Diwanji D
  • A Single Human Papillomavirus Vaccine Dose Improves B Cell Memory in Previously Infected Subjects.
    EBioMedicine Volume: 10 Page(s): 55 - 64
    08/01/2016 Authors: Scherer EM; Smith RA; Gallego DF; Carter JJ; Wipf GC; Hoyos M; Stern M; Thurston T; Trinklein ND; Wald A
  • Sterile inflammation induced by Carbopol elicits robust adaptive immune responses in the absence of pathogen-associated molecular patterns.
    Vaccine Volume: 34 Page(s): 2188 - 2196
    04/27/2016 Authors: Gartlan KH; Krashias G; Wegmann F; Hillson WR; Scherer EM; Greenberg PD; Eisenbarth SC; Moghaddam AE; Sattentau QJ
  • Characteristics of memory B cells elicited by a highly efficacious HPV vaccine in subjects with no pre-existing immunity.
    PLoS Pathog Volume: 10 Page(s): e1004461
    10/01/2014 Authors: Scherer EM; Smith RA; Simonich CA; Niyonzima N; Carter JJ; Galloway DA
  • Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens.
    Nat Biotechnol Volume: 30 Page(s): 883 - 888
    09/01/2012 Authors: Wegmann F; Gartlan KH; Harandi AM; Brinckmann SA; Coccia M; Hillson WR; Kok WL; Cole S; Ho L-P; Lambe T
  • Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions.
    Proc Natl Acad Sci U S A Volume: 107 Page(s): 1529 - 1534
    01/26/2010 Authors: Scherer EM; Leaman DP; Zwick MB; McMichael AJ; Burton DR
  • 25 years of HIV research on virology, virus restriction, immunopathogenesis, genes and vaccines.
    Clin Exp Immunol Volume: 154 Page(s): 6 - 14
    10/01/2008 Authors: Scherer E; Douek D; McMichael A
  • Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity.
    AIDS Volume: 21 Page(s): 2131 - 2139
    10/18/2007 Authors: Scherer EM; Zwick MB; Teyton L; Burton DR
  • Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure.
    Toxicol Appl Pharmacol Volume: 193 Page(s): 281 - 292
    12/01/2003 Authors: Seng JE; Agrawal N; Horsley ETM; Leakey TI; Scherer EM; Xia S; Allaben WT; Leakey JEA
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