Publications

• Building Metabolically Stable and Potent Anti-HIV Thioether-Lipid Analogues of Tenofovir Exalidex: A thorough Pharmacological Analysis.
  J Med Chem Volume: 67 Page(s): 18204 - 18220
  10/24/2024 Authors: D'Erasmo MP; Sharma SK; Pribut N; Basson A; Dasari M; Bartsch P; Iskandar SE; Giesler KE; Burton S; Derdeyn CA
• Phase 2 trial of tremelimumab in patients with metastatic urothelial cancer previously treated with programmed death 1/programmed death ligand 1 blockade.
  Cancer Volume: 130 Page(s): 1642 - 1649
  05/01/2024 Authors: Miller EJ; Rose TL; Maughan BL; Milowsky MI; Bilen MA; Carthon BC; Gao X; Rapisuwon S; Zhao Q; Yu M
• Discovery of 5'-Substituted 5-Fluoro-2'-deoxyuridine Monophosphate Analogs: A Novel Class of Thymidylate Synthase Inhibitors.
  ACS Pharmacol Transl Sci Volume: 6 Page(s): 702 - 709
  05/12/2023 Authors: Dasari M; Pelly SC; Geng J; Gold HB; Pribut N; Sharma SK; D'Erasmo MP; Bartsch PW; Sun C; Toti K
• Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
  J Med Chem Volume: 65 Page(s): 4058 - 4084
  03/10/2022 Authors: Jecs E; Tahirovic YA; Wilson RJ; Miller EJ; Kim M; Truax V; Nguyen HH; Akins NS; Saindane M; Wang T
• Expanding the toolbox of metabolically stable lipid prodrug strategies.
  Front Pharmacol Volume: 13 Page(s): 1083284
  01/01/2022 Authors: Toti KS; Pribut N; D'Erasmo M; Dasari M; Sharma SK; Bartsch PW; Burton SL; Gold HB; Bushnev A; Derdeyn CA
• Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings.
  ACS Med Chem Lett Volume: 12 Page(s): 1605 - 1612
  10/14/2021 Authors: Nguyen HH; Tahirovic YA; Truax VM; Wilson RJ; Jecs E; Miller EJ; Kim MB; Akins NS; Xu L; Jiang Y
• -Functionalized Lipid Prodrugs of HIV NtRTI Tenofovir with Enhanced Pharmacokinetic Properties.
  J Med Chem Volume: 64 Page(s): 12917 - 12937
  09/09/2021 Authors: Pribut N; D'Erasmo M; Dasari M; Giesler KE; Iskandar S; Sharma SK; Bartsch PW; Raghuram A; Bushnev A; Hwang SS
• Small molecule and peptide-based CXCR4 modulators as therapeutic agents. A patent review for the period from 2010 to 2018.
  Expert Opin Ther Pat Volume: 30 Page(s): 87 - 101
  02/01/2020 Authors: Tahirovic YA; Pelly S; Jecs E; Miller EJ; Sharma SK; Liotta DC; Wilson LJ
• Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties.
  J Med Chem Volume: 61 Page(s): 7168 - 7188
  08/23/2018 Authors: Nguyen HH; Kim MB; Wilson RJ; Butch CJ; Kuo KM; Miller EJ; Tahirovic YA; Jecs E; Truax VM; Wang T
• Discovery of N-Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties.
  ACS Med Chem Lett Volume: 9 Page(s): 446 - 451
  05/10/2018 Authors: Tahirovic YA; Truax VM; Wilson RJ; Jecs E; Nguyen HH; Miller EJ; Kim MB; Kuo KM; Wang T; Sum CS
• Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains.
  ACS Med Chem Lett Volume: 9 Page(s): 89 - 93
  02/08/2018 Authors: Jecs E; Miller EJ; Wilson RJ; Nguyen HH; Tahirovic YA; Katzman BM; Truax VM; Kim MB; Kuo KM; Wang T
• Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties.
  J Med Chem Volume: 61 Page(s): 946 - 979
  02/08/2018 Authors: Miller EJ; Jecs E; Truax VM; Katzman BM; Tahirovic YA; Wilson RJ; Kuo KM; Kim MB; Nguyen HH; Saindane MT
• The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor.
  Mol Pharmacol Volume: 93 Page(s): 141 - 156
  02/01/2018 Authors: Kaiser TM; Kell SA; Kusumoto H; Shaulsky G; Bhattacharya S; Epplin MP; Strong KL; Miller EJ; Cox BD; Menaldino DS
• Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists.
  ACS Med Chem Lett Volume: 9 Page(s): 17 - 22
  01/11/2018 Authors: Wilson RJ; Jecs E; Miller EJ; Nguyen HH; Tahirovic YA; Truax VM; Kim MB; Kuo KM; Wang T; Sum CS
• Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties.
  ACS Med Chem Lett Volume: 7 Page(s): 537 - 542
  05/12/2016 Authors: Miller EJ; Mays SG; Baillie MT; Howard RB; Culver DG; Saindane M; Pruett ST; Holt JJ; Menaldino DS; Evers TJ
• Chloride is an Agonist of Group II and III Metabotropic Glutamate Receptors.
  Mol Pharmacol Volume: 88 Page(s): 450 - 459
  09/01/2015 Authors: DiRaddo JO; Miller EJ; Bowman-Dalley C; Wroblewska B; Javidnia M; Grajkowska E; Wolfe BB; Liotta DC; Wroblewski JT
• A real-time method for measuring cAMP production modulated by Gi/o-coupled metabotropic glutamate receptors.
  J Pharmacol Exp Ther Volume: 349 Page(s): 373 - 382
  06/01/2014 Authors: DiRaddo JO; Miller EJ; Hathaway HA; Grajkowska E; Wroblewska B; Wolfe BB; Liotta DC; Wroblewski JT
• Structural Basis of Chloride Selectivity between Group II Metabotropic Glutamate Receptors
  Volume: 12 Page(s): 42 - 42
  01/01/2014 Authors: Miller EJ; DiRaddo JO; Grajkowska E; Wroblewska B; Wolfe BB; Snyder JP; Wroblewski JT; Liotta DC
• Chloride is an Agonist of mGlu3, mGlu4, mGlu6, and mGlu8 Receptors
  Volume: 12 Page(s): 15 - 15
  01/01/2014 Authors: DiRaddo JO; Miller EJ; Grajkowska E; Wroblewska B; Snyder JP; Wolfe BB; Liotta DC; Wroblewski JT
• A Real-Time Method for Measuring cAMP Production Modulated by G alpha(i/o)-Coupled Metabotropic Glutamate Receptors
  Volume: 12 Page(s): 15 - 15
  01/01/2014 Authors: DiRaddo JO; Miller EJ; Hathaway HA; Grajkowska E; Wroblewska B; Wolfe BB; Liotta DC; Wroblewski JT
• FLUORINATION OF ENIGMOL IMPROVES TISSUE UPTAKE AND AFFECTS IN VIVO PROSTATE CANCER EFFICACY
  Volume: 189 Page(s): E133 - E134
  04/01/2013 Authors: Mays SG; Baillie MT; Miller EJ; Bushnev AS; Pruett ST; Culver DG; Evers TJ; Gao J; Reddy GP; Natchus MG
• Ligand bias at metabotropic glutamate 1a receptors: molecular determinants that distinguish -arrestin-mediated from G protein-mediated signaling.
  Mol Pharmacol Volume: 82 Page(s): 291 - 301
  08/01/2012 Authors: Emery AC; DiRaddo JO; Miller E; Hathaway HA; Pshenichkin S; Takoudjou GR; Grajkowska E; Yasuda RP; Wolfe BB; Wroblewski JT
• Progress Towards a Structural Understanding of Selective Activation of mGlu3 over mGlu2 Receptors
  Volume: 9 Page(s): 43 - 43
  09/01/2011 Authors: Miller EJ; DiRaddo J; Pshenichkin S; Wroblewska B; Grajkowska E; Snyder JP; Liotta DC; Wroblewski JT
• Selective Agonists of mGlu3 Receptors: N-Acetylaspatylglutamate (NAAG) and 2-Hydroxymethylglutamate (HMG)
  Volume: 9 Page(s): 67 - 68
  09/01/2011 Authors: Wroblewska B; Pshenichkin S; Miller EJ; DiRaddo J; Grajkowska E; Wroblewski JT