Ellen Hess PhD
- Department of Pharmacology & Chemical Biology
Professor
- (404) 727-4911
- ellen.hess@emory.edu
- Lab website
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Emory University School of Medicine
Pharmacology
101 Woodruff Circle, WMRB Rm 6303
Overview
Our research focuses on the genetic and neuropharmacologic underpinnings of complex behavioral disorders. We work on several different projects under this broad theme, including dystonia, Lesch-Nyhan disease, and channelopathies (episodic neurological disorders). The goal is to better understand and treat these neurological disorders by using a true bench to bedside approach.
Our group consists of basic science and clinical research components. We use a multi-disciplinary approach to determine the contribution of the basal ganglia and cerebellum to different disorders. We manipulate specific subpopulations of neurons using genetically engineered mice, viral vectors or drug challenges by targeting ion channels, receptors or neurotransmitters to cause or suppress dysfunction. We assess the effects of these manipulations on neuronal function and behavior to pinpoint the source of the dysfunctional signal. Our experiments have resulted in the development and characterization of several mouse models of human disease in our lab and in collaboration with others. This strategy provides a better understanding of the mechanisms underlying neurological dysfunction as well as the development of novel treatments.
Our clinical work is aimed primarily at translational research. This includes more precise characterizations of clinical phenotypes, exploring genotype-phenotype relationships, neuroimaging of the brain, biorepositories for exploring biomarkers of disease, and clinical trials of promising new treatments.
Academic Appointment
- Professor (with tenure), Departments of Pharmacology and Neurology, Emory University
- Professor, Departments of Pharmacology and Neurology, Emory University
Education
Degrees
- PhD from University of California
- BA from Wellesley College
Research
Focus
- The general goal is to understand the pathomechanisms of dystonia by examining the underlying anatomical, physiological and biochemical substrates of the disorder. We implement this strategy by creating and manipulating mouse models, which allows us to induce or ameliorate motor dysfunction in the context of an intact nervous system revealing potential targets for therapeutics.
Publications
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The 6-OHDA Parkinson's Disease Mouse Model Shows Deficits in Sensory Behavior.
01/29/2025 Authors: Linen SR; Chang NH; Hess EJ; Stanley GB; Waiblinger C -
Striatal cell-type-specific molecular signatures reveal therapeutic targets in a model of dystonia.
bioRxiv
10/07/2024 Authors: Roman KM; Dinasarapu AR; Cherian S; Fan X; Donsante Y; Aravind N; Chan CS; Jinnah HA; Hess EJ -
Sex Differences in Dystonia.
Mov Disord Clin Pract Volume: 11 Page(s): 973 - 982
08/01/2024 Authors: Kilic-Berkmen G; Scorr LM; McKay L; Thayani M; Donsante Y; Perlmutter JS; Norris SA; Wright L; Klein C; Feuerstein JS -
Ultrastructural analysis of nigrostriatal dopaminergic terminals in a knockin mouse model of DYT1 dystonia.
Eur J Neurosci Volume: 59 Page(s): 1407 - 1427
04/01/2024 Authors: Pan K; Jinnah HA; Hess EJ; Smith Y; Villalba RM -
Spiny projection neurons exhibit transcriptional signatures within subregions of the dorsal striatum.
Cell Rep Volume: 42 Page(s): 113435
11/28/2023 Authors: Roman KM; Dinasarapu AR; VanSchoiack A; Ross PM; Kroeppler D; Jinnah HA; Hess EJ -
Striatal Subregion-selective Dysregulated Dopamine Receptor-mediated Intracellular Signaling in a Model of DOPA-responsive Dystonia.
Neuroscience Volume: 517 Page(s): 37 - 49
05/01/2023 Authors: Roman KM; Briscione MA; Donsante Y; Ingram J; Fan X; Bernhard D; Campbell SA; Downs AM; Gutman D; Sardar TA -
Advances in targeting neurotransmitter systems in dystonia.
Int Rev Neurobiol Volume: 169 Page(s): 217 - 258
01/01/2023 Authors: Steel D; Reid KM; Pisani A; Hess EJ; Fox S; Kurian MA -
Synaptic effects of ethanol on striatal circuitry: therapeutic implications for dystonia.
FEBS J Volume: 289 Page(s): 5834 - 5849
10/01/2022 Authors: Imbriani P; Sciamanna G; El Atiallah I; Cerri S; Hess EJ; Pisani A -
Blockade of M4 muscarinic receptors on striatal cholinergic interneurons normalizes striatal dopamine release in a mouse model of TOR1A dystonia.
Neurobiol Dis Volume: 168 Page(s): 105699
06/15/2022 Authors: Downs AM; Donsante Y; Jinnah HA; Hess EJ -
Striatal Synaptic Dysfunction in Dystonia and Levodopa-Induced Dyskinesia.
Neurobiol Dis Volume: 166 Page(s): 105650
05/01/2022 Authors: Scarduzio M; Hess EJ; Standaert DG; Eskow Jaunarajs KL