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Profile

Ellen Hess PhD

  • Department of Pharmacology & Chemical Biology
    Professor
  • (404) 727-4911
  • ellen.hess@emory.edu
  • Lab website
  • Emory University School of Medicine
    Pharmacology
    101 Woodruff Circle, WMRB Rm 6303
Head shot of Ellen Hess

Overview

Our research focuses on the genetic and neuropharmacologic underpinnings of complex behavioral disorders. We work on several different projects under this broad theme, including dystonia, Lesch-Nyhan disease, and channelopathies (episodic neurological disorders). The goal is to better understand and treat these neurological disorders by using a true bench to bedside approach.

Our group consists of basic science and clinical research components. We use a multi-disciplinary approach to determine the contribution of the basal ganglia and cerebellum to different disorders. We manipulate specific subpopulations of neurons using genetically engineered mice, viral vectors or drug challenges by targeting ion channels, receptors or neurotransmitters to cause or suppress dysfunction. We assess the effects of these manipulations on neuronal function and behavior to pinpoint the source of the dysfunctional signal. Our experiments have resulted in the development and characterization of several mouse models of human disease in our lab and in collaboration with others. This strategy provides a better understanding of the mechanisms underlying neurological dysfunction as well as the development of novel treatments.

Our clinical work is aimed primarily at translational research. This includes more precise characterizations of clinical phenotypes, exploring genotype-phenotype relationships, neuroimaging of the brain, biorepositories for exploring biomarkers of disease, and clinical trials of promising new treatments.

Academic Appointment

  • Professor (with tenure), Departments of Pharmacology and Neurology, Emory University
  • Professor, Departments of Pharmacology and Neurology, Emory University

Education

Degrees

  • PhD from University of California
  • BA from Wellesley College

Research

Focus

  • The general goal is to understand the pathomechanisms of dystonia by examining the underlying anatomical, physiological and biochemical substrates of the disorder. We implement this strategy by creating and manipulating mouse models, which allows us to induce or ameliorate motor dysfunction in the context of an intact nervous system revealing potential targets for therapeutics.

Publications

  • The 6-OHDA Parkinson's Disease Mouse Model Shows Deficits in Sensory Behavior.

    01/29/2025 Authors: Linen SR; Chang NH; Hess EJ; Stanley GB; Waiblinger C
  • Striatal cell-type-specific molecular signatures reveal therapeutic targets in a model of dystonia.
    bioRxiv
    10/07/2024 Authors: Roman KM; Dinasarapu AR; Cherian S; Fan X; Donsante Y; Aravind N; Chan CS; Jinnah HA; Hess EJ
  • Sex Differences in Dystonia.
    Mov Disord Clin Pract Volume: 11 Page(s): 973 - 982
    08/01/2024 Authors: Kilic-Berkmen G; Scorr LM; McKay L; Thayani M; Donsante Y; Perlmutter JS; Norris SA; Wright L; Klein C; Feuerstein JS
  • Ultrastructural analysis of nigrostriatal dopaminergic terminals in a knockin mouse model of DYT1 dystonia.
    Eur J Neurosci Volume: 59 Page(s): 1407 - 1427
    04/01/2024 Authors: Pan K; Jinnah HA; Hess EJ; Smith Y; Villalba RM
  • Spiny projection neurons exhibit transcriptional signatures within subregions of the dorsal striatum.
    Cell Rep Volume: 42 Page(s): 113435
    11/28/2023 Authors: Roman KM; Dinasarapu AR; VanSchoiack A; Ross PM; Kroeppler D; Jinnah HA; Hess EJ
  • Striatal Subregion-selective Dysregulated Dopamine Receptor-mediated Intracellular Signaling in a Model of DOPA-responsive Dystonia.
    Neuroscience Volume: 517 Page(s): 37 - 49
    05/01/2023 Authors: Roman KM; Briscione MA; Donsante Y; Ingram J; Fan X; Bernhard D; Campbell SA; Downs AM; Gutman D; Sardar TA
  • Advances in targeting neurotransmitter systems in dystonia.
    Int Rev Neurobiol Volume: 169 Page(s): 217 - 258
    01/01/2023 Authors: Steel D; Reid KM; Pisani A; Hess EJ; Fox S; Kurian MA
  • Synaptic effects of ethanol on striatal circuitry: therapeutic implications for dystonia.
    FEBS J Volume: 289 Page(s): 5834 - 5849
    10/01/2022 Authors: Imbriani P; Sciamanna G; El Atiallah I; Cerri S; Hess EJ; Pisani A
  • Blockade of M4 muscarinic receptors on striatal cholinergic interneurons normalizes striatal dopamine release in a mouse model of TOR1A dystonia.
    Neurobiol Dis Volume: 168 Page(s): 105699
    06/15/2022 Authors: Downs AM; Donsante Y; Jinnah HA; Hess EJ
  • Striatal Synaptic Dysfunction in Dystonia and Levodopa-Induced Dyskinesia.
    Neurobiol Dis Volume: 166 Page(s): 105650
    05/01/2022 Authors: Scarduzio M; Hess EJ; Standaert DG; Eskow Jaunarajs KL
  • Neuropathology of blepharospasm.
    Exp Neurol Volume: 346 Page(s): 113855
    12/01/2021 Authors: Fagan M; Scorr L; Bernhardt D; Hess EJ; Perlmutter JS; Pardo CA; Jinnah HA
  • Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy.
    ACS Pharmacol Transl Sci Volume: 4 Page(s): 1306 - 1321
    08/13/2021 Authors: Moehle MS; Bender AM; Dickerson JW; Foster DJ; Qi A; Cho HP; Donsante Y; Peng W; Bryant Z; Stillwell KJ
  • Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders.
    Mol Genet Metab Volume: 133 Page(s): 352 - 361
    08/01/2021 Authors: Briscione MA; Dinasarapu AR; Bagchi P; Donsante Y; Roman KM; Downs AM; Fan X; Hoehner J; Jinnah HA; Hess EJ
  • Cell-intrinsic effects of TorsinA(E) disrupt dopamine release in a mouse model of TOR1A dystonia.
    Neurobiol Dis Volume: 155 Page(s): 105369
    07/01/2021 Authors: Downs AM; Fan X; Kadakia RF; Donsante Y; Jinnah HA; Hess EJ
  • Induced pluripotent stem cells from subjects with Lesch-Nyhan disease.
    Sci Rep Volume: 11 Page(s): 8523
    04/19/2021 Authors: Sutcliffe DJ; Dinasarapu AR; Visser JE; Hoed JD; Seifar F; Joshi P; Ceballos-Picot I; Sardar T; Hess EJ; Sun YV
  • The neurobiological basis for novel experimental therapeutics in dystonia.
    Neurobiol Dis Volume: 130 Page(s): 104526
    10/01/2019 Authors: Downs AM; Roman KM; Campbell SA; Pisani A; Hess EJ; Bonsi P
  • Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia.
    Neurobiol Dis Volume: 125 Page(s): 115 - 122
    05/01/2019 Authors: Downs AM; Fan X; Donsante C; Jinnah HA; Hess EJ
  • Aberrant cerebellar Purkinje cell activity as the cause of motor attacks in a mouse model of episodic ataxia type 2.
    Dis Model Mech Volume: 11
    09/21/2018 Authors: Tara E; Vitenzon A; Hess E; Khodakhah K
  • Dopamine Receptor Agonist Treatment of Idiopathic Dystonia: A Reappraisal in Humans and Mice.
    J Pharmacol Exp Ther Volume: 365 Page(s): 20 - 26
    04/01/2018 Authors: Fan X; Donsante Y; Jinnah HA; Hess EJ
  • Striatal ERK is Activated in Response to L-DOPA Administration in a Knock-in Mouse Model of DOPA-Responsive Dystonia
    Volume: 32
    04/01/2018 Authors: Briscione M; Donsante C; Fan X; Campbell S; Bernhard D; Downs A; Gutman D; Sardar T; Shannon A; Sutcliffe DJ
  • Evolving concepts in the pathogenesis of dystonia.
    Parkinsonism Relat Disord Volume: 46 Suppl 1 Page(s): S62 - S65
    01/01/2018 Authors: Jinnah HA; Hess EJ
  • Effects of disulfiram on choice behavior in a rodent gambling task: association with catecholamine levels.
    Psychopharmacology (Berl) Volume: 235 Page(s): 23 - 35
    01/01/2018 Authors: Di Ciano P; Manvich DF; Pushparaj A; Gappasov A; Hess EJ; Weinshenker D; Le Foll B
  • Striatal Cholinergic Interneurons in a Knock-in Mouse Model of L-DOPA-Responsive Dystonia.
    Front Syst Neurosci Volume: 12 Page(s): 28
    01/01/2018 Authors: Yalcin-Cakmakli G; Rose SJ; Villalba RM; Williams L; Jinnah HA; Hess EJ; Smith Y
  • Parkinsonism without dopamine neuron degeneration in aged l-dopa-responsive dystonia knockin mice.
    Mov Disord Volume: 32 Page(s): 1694 - 1700
    12/01/2017 Authors: Rose SJ; Harrast P; Donsante C; Fan X; Joers V; Tansey MG; Jinnah HA; Hess EJ
  • Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia.
    Cerebellum Volume: 16 Page(s): 577 - 594
    04/01/2017 Authors: Shakkottai VG; Batla A; Bhatia K; Dauer WT; Dresel C; Niethammer M; Eidelberg D; Raike RS; Smith Y; Jinnah HA
  • The Anatomical Basis for Dystonia: The Motor Network Model.
    Tremor Other Hyperkinet Mov (N Y) Volume: 7 Page(s): 506
    01/01/2017 Authors: Jinnah HA; Neychev V; Hess EJ
  • A Functional Magnetic Resonance Imaging Study of Head Movements in Cervical Dystonia.
    Front Neurol Volume: 7 Page(s): 201
    01/01/2016 Authors: Prudente CN; Stilla R; Singh S; Buetefisch C; Evatt M; Factor SA; Freeman A; Hu XP; Hess EJ; Sathian K
  • A commentary on the utility of a new L-DOPA-responsive dystonia mouse model.
    Rare Dis Volume: 4 Page(s): e1128617
    01/01/2016 Authors: Rose SJ; Hess EJ
  • A new knock-in mouse model of l-DOPA-responsive dystonia.
    Brain Volume: 138 Page(s): 2987 - 3002
    10/01/2015 Authors: Rose SJ; Yu XY; Heinzer AK; Harrast P; Fan X; Raike RS; Thompson VB; Pare J-F; Weinshenker D; Smith Y
  • Dystonia and cerebellar degeneration in the leaner mouse mutant.
    Brain Res Volume: 1611 Page(s): 56 - 64
    06/22/2015 Authors: Raike RS; Hess EJ; Jinnah HA
  • Neural Substrates for Head Movements in Humans: A Functional Magnetic Resonance Imaging Study.
    J Neurosci Volume: 35 Page(s): 9163 - 9172
    06/17/2015 Authors: Prudente CN; Stilla R; Buetefisch CM; Singh S; Hess EJ; Hu X; Sathian K; Jinnah HA
  • Neural substrates for head movements in cervical dystonia: A functional magnetic resonance imaging study
    Volume: 30 Page(s): S391 - S392
    06/01/2015 Authors: Prudente CN; Stilla R; Singh S; Buetefisch C; Hu X; Hess EJ; Sathian K; Jinnah HA
  • The first knockin mouse model of episodic ataxia type 2.
    Exp Neurol Volume: 261 Page(s): 553 - 562
    11/01/2014 Authors: Rose SJ; Kriener LH; Heinzer AK; Fan X; Raike RS; van den Maagdenberg AMJM; Hess EJ
  • Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): 9977 - 9982
    07/08/2014 Authors: Lohr KM; Bernstein AI; Stout KA; Dunn AR; Lazo CR; Alter SP; Wang M; Li Y; Fan X; Hess EJ
  • Dystonia as a network disorder: what is the role of the cerebellum?
    Neuroscience Volume: 260 Page(s): 23 - 35
    02/28/2014 Authors: Prudente CN; Hess EJ; Jinnah HA
  • Subtle microstructural changes of the cerebellum in a knock-in mouse model of DYT1 dystonia.
    Neurobiol Dis Volume: 62 Page(s): 372 - 380
    02/01/2014 Authors: Song C-H; Bernhard D; Hess EJ; Jinnah HA
  • Animal models for dystonia.
    Mov Disord Volume: 28 Page(s): 982 - 989
    06/15/2013 Authors: Wilson BK; Hess EJ
  • Subtle microstructural changes of the striatum in a DYT1 knock-in mouse model of dystonia.
    Neurobiol Dis Volume: 54 Page(s): 362 - 371
    06/01/2013 Authors: Song C-H; Bernhard D; Bolarinwa C; Hess EJ; Smith Y; Jinnah HA
  • Neuropathology of cervical dystonia.
    Exp Neurol Volume: 241 Page(s): 95 - 104
    03/01/2013 Authors: Prudente CN; Pardo CA; Xiao J; Hanfelt J; Hess EJ; Ledoux MS; Jinnah HA
  • Stress, caffeine and ethanol trigger transient neurological dysfunction through shared mechanisms in a mouse calcium channelopathy.
    Neurobiol Dis Volume: 50 Page(s): 151 - 159
    02/01/2013 Authors: Raike RS; Weisz C; Hoebeek FE; Terzi MC; De Zeeuw CI; van den Maagdenberg AM; Jinnah HA; Hess EJ
  • Limited regional cerebellar dysfunction induces focal dystonia in mice.
    Neurobiol Dis Volume: 49 Page(s): 200 - 210
    01/01/2013 Authors: Raike RS; Pizoli CE; Weisz C; van den Maagdenberg AMJM; Jinnah HA; Hess EJ
  • Functional analysis of dopaminergic systems in a DYT1 knock-in mouse model of dystonia.
    Neurobiol Dis Volume: 48 Page(s): 66 - 78
    10/01/2012 Authors: Song C-H; Fan X; Exeter CJ; Hess EJ; Jinnah HA
  • Dopamine Dysregulation in a Mouse Model of Paroxysmal Non-Kinesigenic Dyskinesia
    Volume: 78
    04/01/2012 Authors: Lee H-Y; Pothos E; Hess EJ; Fu Y-H; Edwards R; Ptacek L
  • Dopamine Dysregulation in a Mouse Model of Paroxysmal Non-Kinesigenic Dyskinesia
    Volume: 78
    04/01/2012 Authors: Lee H-Y; Pothos E; Hess EJ; Fu Y-H; Edwards R; Ptacek L
  • Purkinje cell-specific ablation of Cav2.1 channels is sufficient to cause cerebellar ataxia in mice.
    Cerebellum Volume: 11 Page(s): 246 - 258
    03/01/2012 Authors: Todorov B; Kros L; Shyti R; Plak P; Haasdijk ED; Raike RS; Frants RR; Hess EJ; Hoebeek FE; De Zeeuw CI
  • Selective and sustained -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation in cerebellum induces dystonia in mice.
    J Pharmacol Exp Ther Volume: 340 Page(s): 733 - 741
    03/01/2012 Authors: Fan X; Hughes KE; Jinnah HA; Hess EJ
  • Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia.
    J Clin Invest Volume: 122 Page(s): 507 - 518
    02/01/2012 Authors: Lee H-Y; Nakayama J; Xu Y; Fan X; Karouani M; Shen Y; Pothos EN; Hess EJ; Fu Y-H; Edwards RH
  • Rodent models of ADHD.
    Curr Top Behav Neurosci Volume: 9 Page(s): 273 - 300
    01/01/2012 Authors: Fan X; Bruno KJ; Hess EJ
  • Convergent mechanisms in etiologically-diverse dystonias.
    Expert Opin Ther Targets Volume: 15 Page(s): 1387 - 1403
    12/01/2011 Authors: Thompson VB; Jinnah HA; Hess EJ
  • A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias.
    Neurology Volume: 77 Page(s): 1996 - 1997
    11/29/2011 Authors: Hess E
  • The functional neuroanatomy of dystonia.
    Neurobiol Dis Volume: 42 Page(s): 185 - 201
    05/01/2011 Authors: Neychev VK; Gross RE; Lehricy S; Hess EJ; Jinnah HA
  • Neuronal voltage-gated calcium channels: brief overview of their function and clinical implications in neurology.
    Neurology Volume: 75 Page(s): 937
    09/07/2010 Authors: Hess EJ; Jen JC; Jinnah HA; Benarroch EE
  • Kinematic and electromyographic tools for characterizing movement disorders in mice.
    Mov Disord Volume: 25 Page(s): 265 - 274
    02/15/2010 Authors: Scholle HC; Jinnah HA; Arnold D; Biedermann FHW; Faenger B; Grassme R; Hess EJ; Schumann NP
  • D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD.
    Neurobiol Dis Volume: 37 Page(s): 228 - 236
    01/01/2010 Authors: Fan X; Xu M; Hess EJ
  • Low-frequency oscillations in the cerebellar cortex of the tottering mouse.
    J Neurophysiol Volume: 101 Page(s): 234 - 245
    01/01/2009 Authors: Chen G; Popa LS; Wang X; Gao W; Barnes J; Hendrix CM; Hess EJ; Ebner TJ
  • The basal ganglia and cerebellum interact in the expression of dystonic movement.
    Brain Volume: 131 Page(s): 2499 - 2509
    09/01/2008 Authors: Neychev VK; Fan X; Mitev VI; Hess EJ; Jinnah HA
  • Experimental therapeutics for dystonia.
    Neurotherapeutics Volume: 5 Page(s): 198 - 209
    04/01/2008 Authors: Jinnah HA; Hess EJ
  • Paroxysmal dyskinesias in mice.
    Mov Disord Volume: 23 Page(s): 259 - 264
    01/30/2008 Authors: Shirley TL; Rao LM; Hess EJ; Jinnah HA
  • Animal models for drug discovery in dystonia.
    Expert Opin Drug Discov Volume: 3 Page(s): 83 - 97
    01/01/2008 Authors: Jinnah H; Richter A; Mink JW; Caldwell GA; Caldwell KA; Gonzalez-Alegre P; Cookson MR; Breakefield XO; Delong MR; Hess EJ
  • Primary episodic ataxias: diagnosis, pathogenesis and treatment.
    Brain Volume: 130 Page(s): 2484 - 2493
    10/01/2007 Authors: Jen JC; Graves TD; Hess EJ; Hanna MG; Griggs RC; Baloh RW; CINCH investigators
  • Neuroanatomical substrates for paroxysmal dyskinesia in lethargic mice.
    Neurobiol Dis Volume: 27 Page(s): 249 - 257
    09/01/2007 Authors: Devanagondi R; Egami K; LeDoux MS; Hess EJ; Jinnah HA
  • D2-like dopamine receptors mediate the response to amphetamine in a mouse model of ADHD.
    Neurobiol Dis Volume: 26 Page(s): 201 - 211
    04/01/2007 Authors: Fan X; Hess EJ
  • Neuroanatomy of dystonia: A motor network concept
    Volume: 22 Page(s): S45 - S45
    01/01/2007 Authors: Neychev VK; Hess EJ; Mitev VI; Jinnah HA
  • Abnormal latent inhibition and impulsivity in coloboma mice, a model of ADHD.
    Neurobiol Dis Volume: 25 Page(s): 206 - 216
    01/01/2007 Authors: Bruno KJ; Freet CS; Twining RC; Egami K; Grigson PS; Hess EJ
  • A new twist on the anatomy of dystonia: the basal ganglia and the cerebellum?
    Neurology Volume: 67 Page(s): 1740 - 1741
    11/28/2006 Authors: Jinnah HA; Hess EJ
  • The alpha(2C)-adrenergic receptor mediates hyperactivity of coloboma mice, a model of attention deficit hyperactivity disorder.
    Neurobiol Dis Volume: 23 Page(s): 679 - 688
    09/01/2006 Authors: Bruno KJ; Hess EJ
  • Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.
    J Neurosci Volume: 26 Page(s): 3685 - 3696
    04/05/2006 Authors: von Coelln R; Thomas B; Andrabi SA; Lim KL; Savitt JM; Saffary R; Stirling W; Bruno K; Hess EJ; Lee MK
  • The role of dopamine receptors in the neurobehavioral syndrome provoked by activation of L-type calcium channels in rodents.
    Dev Neurosci Volume: 28 Page(s): 505 - 517
    01/01/2006 Authors: Kasim S; Blake BL; Fan X; Chartoff E; Egami K; Breese GR; Hess EJ; Jinnah HA
  • Noradrenergic blockade prevents attacks in a model of episodic dysfunction caused by a channelopathy.
    Neurobiol Dis Volume: 20 Page(s): 227 - 232
    11/01/2005 Authors: Fureman BE; Hess EJ
  • Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.
    Exp Neurol Volume: 195 Page(s): 208 - 217
    09/01/2005 Authors: Pan B; Fromholt SE; Hess EJ; Crawford TO; Griffin JW; Sheikh KA; Schnaar RL
  • Animal models of generalized dystonia.
    NeuroRx Volume: 2 Page(s): 504 - 512
    07/01/2005 Authors: Raike RS; Jinnah HA; Hess EJ
  • Sturge-Weber syndrome: altered blood vessel fibronectin expression and morphology.
    J Child Neurol Volume: 20 Page(s): 572 - 577
    07/01/2005 Authors: Comi AM; Weisz CJC; Highet BH; Skolasky RL; Pardo CA; Hess EJ
  • Potassium channel blockers inhibit the triggers of attacks in the calcium channel mouse mutant tottering.
    J Neurosci Volume: 25 Page(s): 4141 - 4145
    04/20/2005 Authors: Weisz CJC; Raike RS; Soria-Jasso LE; Hess EJ
  • Rodent models for dystonia research: characteristics, evaluation, and utility.
    Mov Disord Volume: 20 Page(s): 283 - 292
    03/01/2005 Authors: Jinnah HA; Hess EJ; Ledoux MS; Sharma N; Baxter MG; Delong MR
  • Loss of locus coeruleus neurons and reduced startle in parkin null mice.
    Proc Natl Acad Sci U S A Volume: 101 Page(s): 10744 - 10749
    07/20/2004 Authors: Von Coelln R; Thomas B; Savitt JM; Lim KL; Sasaki M; Hess EJ; Dawson VL; Dawson TM
  • Norepinephrine regulates locomotor hyperactivity in the mouse mutant coloboma.
    Pharmacol Biochem Behav Volume: 75 Page(s): 209 - 216
    04/01/2003 Authors: Jones MD; Hess EJ
  • Expression of c-FOS in the brain after activation of L-type calcium channels.
    Dev Neurosci Volume: 25 Page(s): 403 - 411
    01/01/2003 Authors: Jinnah HA; Egami K; Rao L; Shin M; Kasim S; Hess EJ
  • Regulation of tyrosine hydroxylase expression in tottering mouse Purkinje cells.
    Neurotox Res Volume: 5 Page(s): 521 - 528
    01/01/2003 Authors: Fureman BE; Campbell DB; Hess EJ
  • Triggers of paroxysmal dyskinesia in the calcium channel mouse mutant tottering.
    Pharmacol Biochem Behav Volume: 73 Page(s): 631 - 637
    10/01/2002 Authors: Fureman BE; Jinnah HA; Hess EJ
  • Abnormal cerebellar signaling induces dystonia in mice.
    J Neurosci Volume: 22 Page(s): 7825 - 7833
    09/01/2002 Authors: Pizoli CE; Jinnah HA; Billingsley ML; Hess EJ
  • Expression of catecholaminergic mRNAs in the hyperactive mouse mutant coloboma.
    Brain Res Mol Brain Res Volume: 96 Page(s): 114 - 121
    11/30/2001 Authors: Jones MD; Williams ME; Hess EJ
  • Abnormal presynaptic catecholamine regulation in a hyperactive SNAP-25-deficient mouse mutant.
    Pharmacol Biochem Behav Volume: 68 Page(s): 669 - 676
    04/01/2001 Authors: Jones MD; Williams ME; Hess EJ
  • Amperometric analysis of exocytosis at chromaffin cells from genetically distinct mice.
    J Neurosci Methods Volume: 105 Page(s): 95 - 103
    01/30/2001 Authors: Colliver TL; Hess EJ; Ewing AG
  • Iron deficiency decreases dopamine D1 and D2 receptors in rat brain.
    Pharmacol Biochem Behav Volume: 69 Page(s): 409 - 418
    01/01/2001 Authors: Erikson KM; Jones BC; Hess EJ; Zhang Q; Beard JL
  • Calcium channel agonists and dystonia in the mouse.
    Mov Disord Volume: 15 Page(s): 542 - 551
    05/01/2000 Authors: Jinnah HA; Sepkuty JP; Ho T; Yitta S; Drew T; Rothstein JD; Hess EJ
  • Quantitative and statistical analysis of the shape of amperometric spikes recorded from two populations of cells.
    J Neurochem Volume: 74 Page(s): 1086 - 1097
    03/01/2000 Authors: Colliver TL; Hess EJ; Pothos EN; Sulzer D; Ewing AG
  • Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant background.
    Exp Neurol Volume: 160 Page(s): 268 - 278
    11/01/1999 Authors: Campbell DB; North JB; Hess EJ
  • L-type calcium channel regulation of abnormal tyrosine hydroxylase expression in cerebella of tottering mice.
    Ann N Y Acad Sci Volume: 868 Page(s): 217 - 219
    04/30/1999 Authors: Fureman BE; Campbell DB; Hess EJ
  • Purkinje neurons are not required for manganese accumulation by mouse cerebellum.
    FASEB JOURNAL Volume: 13 Page(s): A1101 - A1101
    03/15/1999 Authors: Malecki EA; Campbell D; Hess EJ; Connor JR
  • Characterization and distribution of ferritin binding sites in the adult mouse brain.
    J Neurochem Volume: 72 Page(s): 868 - 874
    02/01/1999 Authors: Hulet SW; Hess EJ; Debinski W; Arosio P; Bruce K; Powers S; Connor JR
  • Influence of age and strain on striatal dopamine loss in a genetic mouse model of Lesch-Nyhan disease.
    J Neurochem Volume: 72 Page(s): 225 - 229
    01/01/1999 Authors: Jinnah HA; Jones MD; Wojcik BE; Rothstein JD; Hess EJ; Friedmann T; Breese GR
  • L-type calcium channels contribute to the tottering mouse dystonic episodes.
    Mol Pharmacol Volume: 55 Page(s): 23 - 31
    01/01/1999 Authors: Campbell DB; Hess EJ
  • Cerebellar circuitry is activated during convulsive episodes in the tottering (tg/tg) mutant mouse.
    Neuroscience Volume: 85 Page(s): 773 - 783
    08/01/1998 Authors: Campbell DB; Hess EJ
  • Rapid genotyping of mutant mice using dried blood spots for polymerase chain reaction (PCR) analysis.
    Brain Res Brain Res Protoc Volume: 1 Page(s): 117 - 123
    05/01/1997 Authors: Campbell DB; Hess EJ
  • Migraines in mice?
    Cell Volume: 87 Page(s): 1149 - 1151
    12/27/1996 Authors: Hess EJ
  • The Use of Transgenes and Mutations in the Mouse to Study the Genetic Basis of Locomotor Hyperactivity.
    Methods Volume: 10 Page(s): 374 - 383
    12/01/1996 Authors: Hess EJ
  • SNAP-25, enSNAREd in neurotransmission and regulation of behaviour.
    Biochem Soc Trans Volume: 24 Page(s): 670 - 676
    08/01/1996 Authors: Wilson MC; Mehta PP; Hess EJ
  • Identification of the weaver mouse mutation: the end of the beginning.
    Neuron Volume: 16 Page(s): 1073 - 1076
    06/01/1996 Authors: Hess EJ
  • Mouse model of hyperkinesis implicates SNAP-25 in behavioral regulation.
    J Neurosci Volume: 16 Page(s): 3104 - 3111
    05/01/1996 Authors: Hess EJ; Collins KA; Wilson MC
  • Chromosomal localization of the neurological mouse mutations tottering (tg), Purkinje cell degeneration (pcd), and nervous (nr).
    Brain Res Mol Brain Res Volume: 37 Page(s): 79 - 84
    04/01/1996 Authors: Campbell DB; Hess EJ
  • Absence of linkage of apparently single gene mediated ADHD with the human syntenic region of the mouse mutant Coloboma.
    Am J Med Genet Volume: 60 Page(s): 573 - 579
    12/18/1995 Authors: Hess EJ; Rogan PK; Domoto M; Tinker DE; Ladda RL; Ramer JC
  • Deletion map of the coloboma (Cm) locus on mouse chromosome 2.
    Genomics Volume: 21 Page(s): 257 - 261
    05/01/1994 Authors: Hess EJ; Collins KA; Copeland NG; Jenkins NA; Wilson MC
  • Spontaneous locomotor hyperactivity in a mouse mutant with a deletion including the Snap gene on chromosome 2.
    J Neurosci Volume: 12 Page(s): 2865 - 2874
    07/01/1992 Authors: Hess EJ; Jinnah HA; Kozak CA; Wilson MC
  • Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization.
    Mol Cell Neurosci Volume: 3 Page(s): 64 - 78
    02/01/1992 Authors: Jinnah HA; Hess EJ; Wilson MC; Gage FH; Friedmann T
  • Tottering and leaner mutations perturb transient developmental expression of tyrosine hydroxylase in embryologically distinct Purkinje cells.
    Neuron Volume: 6 Page(s): 123 - 132
    01/01/1991 Authors: Hess EJ; Wilson MC
  • Lesions of hippocampal circuitry define synaptosomal-associated protein-25 (SNAP-25) as a novel presynaptic marker.
    Neuroscience Volume: 38 Page(s): 515 - 525
    01/01/1990 Authors: Geddes JW; Hess EJ; Hart RA; Kesslak JP; Cotman CW; Wilson MC
  • Chronic treatment with dopamine receptor antagonists: behavioral and pharmacologic effects on D1 and D2 dopamine receptors.
    J Neurosci Volume: 8 Page(s): 2361 - 2370
    07/01/1988 Authors: Hess EJ; Norman AB; Creese I
  • Dopamine receptor subtype imbalance in schizophrenia.
    Life Sci Volume: 40 Page(s): 1487 - 1497
    04/13/1987 Authors: Hess EJ; Bracha HS; Kleinman JE; Creese I
  • Differential modification of striatal D1 dopamine receptors and effector moieties by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vivo and in vitro.
    Mol Pharmacol Volume: 31 Page(s): 50 - 57
    01/01/1987 Authors: Hess EJ; Battaglia G; Norman AB; Creese I
  • Functional recovery of D1 dopamine receptor-mediated stimulation of rat striatal adenylate cyclase activity following irreversible receptor modification by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ): evidence for spare receptors.
    Neurosci Lett Volume: 69 Page(s): 290 - 295
    09/12/1986 Authors: Battaglia G; Norman AB; Hess EJ; Creese I
  • Effects of chronic SCH23390 treatment on the biochemical and behavioral properties of D1 and D2 dopamine receptors: potentiated behavioral responses to a D2 dopamine agonist after selective D1 dopamine receptor upregulation.
    J Pharmacol Exp Ther Volume: 238 Page(s): 846 - 854
    09/01/1986 Authors: Hess EJ; Albers LJ; Le H; Creese I
  • Forskolin potentiates the stimulation of rat striatal adenylate cyclase mediated by D-1 dopamine receptors, guanine nucleotides, and sodium fluoride.
    J Neurochem Volume: 46 Page(s): 1180 - 1185
    04/01/1986 Authors: Battaglia G; Norman AB; Hess EJ; Creese I
  • Guanine nucleotide regulation of agonist interactions at [3H]SCH23390-labeled D1 dopamine receptors in rat striatum.
    Eur J Pharmacol Volume: 121 Page(s): 31 - 38
    02/11/1986 Authors: Hess EJ; Battaglia G; Norman AB; Iorio LC; Creese I
  • Biochemical and behavioral studies of D1 dopamine receptors utilizing SCH 23390.
    Psychopharmacol Bull Volume: 22 Page(s): 605 - 612
    01/01/1986 Authors: Hess EJ; Creese I
  • Biochemical and behavioral studies of D1 dopamine receptors utilizing SCH 23390.
    Volume: 204 Page(s): 29 - 52
    01/01/1986 Authors: Hess EJ; Creese I
  • Biochemical characteristics of D1 dopamine receptors: relationship to behavior and schizophrenia.
    Clin Neuropharmacol Volume: 9 Suppl 4 Page(s): 14 - 16
    01/01/1986 Authors: Creese I; Hess EJ
  • D2 dopamine receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat striatum.
    Neurosci Lett Volume: 59 Page(s): 177 - 182
    08/30/1985 Authors: Battaglia G; Norman AB; Hess EJ; Creese I
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