Publications

• Lifting the curse from high-dimensional data: automated projection pursuit clustering for a variety of biological data modalities.
  Gigascience Volume: 14
  01/06/2025 Authors: Simpson C; Tabatsky E; Rahil Z; Eddins DJ; Tkachev S; Georgescauld F; Papalegis D; Culka M; Levy T; Gregoretti I
• Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE.
  Nat Immunol Volume: 26 Page(s): 131 - 145
  01/01/2025 Authors: Faliti CE; Van TTP; Anam FA; Cheedarla N; Williams ME; Mishra AK; Usman SY; Woodruff MC; Kraker G; Runnstrom MC
• Publisher Correction: Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE.
  Nat Immunol Volume: 26 Page(s): 148
  01/01/2025 Authors: Faliti CE; Van TTP; Anam FA; Cheedarla N; Williams ME; Mishra AK; Usman SY; Woodruff MC; Kraker G; Runnstrom MC
• Transient anti-interferon autoantibodies in the airways are associated with recovery from COVID-19.
  Sci Transl Med Volume: 16 Page(s): eadq1789
  11/06/2024 Authors: Babcock BR; Kosters A; Eddins DJ; Donaire MSB; Sarvadhavabhatla S; Pae V; Beltran F; Murray VW; Gill G; Xie G
• Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Niche Factors.
  Stem Cells Volume: 41 Page(s): 944 - 957
  10/08/2023 Authors: Wang Z; Emmel G; Lim HS; Zhu W; Kosters A; Ghosn EEB; Qiu P; Bunting KD
• Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses.
  Cell Rep Volume: 42 Page(s): 112682
  07/25/2023 Authors: Duan M; Nguyen DC; Joyner CJ; Saney CL; Tipton CM; Andrews J; Lonial S; Kim C; Hentenaar I; Kosters A
• Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma.
  Nat Commun Volume: 14 Page(s): 1839
  04/03/2023 Authors: Chen Z; Soni N; Pinero G; Giotti B; Eddins DJ; Lindblad KE; Ross JL; Puigdelloses Vallcorba M; Joshi T; Angione A
• Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load.
  Blood Adv Volume: 7 Page(s): 778 - 799
  03/14/2023 Authors: Eddins DJ; Yang J; Kosters A; Giacalone VD; Pechuan-Jorge X; Chandler JD; Eum J; Babcock BR; Dobosh BS; Hernndez MR
• Profiling the peripheral immune response to ex vivo TNF stimulation in untreated juvenile idiopathic arthritis using single cell RNA sequencing.
  Pediatr Rheumatol Online J Volume: 21 Page(s): 17
  02/15/2023 Authors: Imbach KJ; Treadway NJ; Prahalad V; Kosters A; Arafat D; Duan M; Gergely T; Ponder LA; Chandrakasan S; Ghosn EEB
• Assessing Cellular and Transcriptional Diversity of Ileal Mucosa Among Treatment-Nave and Treated Crohn's Disease.
  Inflamm Bowel Dis Volume: 29 Page(s): 274 - 285
  02/01/2023 Authors: Maddipatla SC; Kolachala VL; Venkateswaran S; Dodd AF; Pelia RS; Geem D; Yin H; Sun Y; Xu C; Mo A
• Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses.
  bioRxiv
  01/20/2023 Authors: Duan M; Nguyen DC; Joyner CJ; Saney CL; Tipton CM; Andrews J; Lonial S; Kim C; Hentenaar I; Kosters A
• ELIMINATING MONOCYTE CHEMOATTRACTION INVOKES COMPENSATORY NEUTROPHIL INFLUX AND PRONEURAL TO MESENCHYMAL TRANSITION IN GLIOBLASTOMA
  Volume: 24 Page(s): 136 - 136
  11/01/2022 Authors: Chen Z; Soni N; Pinero G; Giotti B; Eddins D; Lindblad K; Ross J; Tsankova N; Gutmann D; Lira S
• Comprehensive multi-omics single-cell data integration reveals greater heterogeneity in the human immune system.
  iScience Volume: 25 Page(s): 105123
  10/21/2022 Authors: Xu C; Yang J; Kosters A; Babcock BR; Qiu P; Ghosn EEB
• Baricitinib attenuates the proinflammatory phase of COVID-19 driven by lung-infiltrating monocytes.
  Cell Rep Volume: 39 Page(s): 110945
  06/14/2022 Authors: Dobosh B; Zandi K; Giraldo DM; Goh SL; Musall K; Aldeco M; LeCher J; Giacalone VD; Yang J; Eddins DJ
• Inactivation of SARS-CoV-2 and COVID-19 Patient Samples for Contemporary Immunology and Metabolomics Studies.
  Immunohorizons Volume: 6 Page(s): 144 - 155
  02/16/2022 Authors: Eddins DJ; Bassit LC; Chandler JD; Haddad NS; Musall KL; Yang J; Kosters A; Dobosh BS; Hernndez MR; Ramonell RP
• Regulation of the BCR signalosome by the class II peptide editor, H2-M, affects the development and repertoire of innate-like B cells.
  Cell Rep Volume: 38 Page(s): 110200
  01/25/2022 Authors: Ghosh D; Pham TD; Nanaware PP; Sengupta D; Adler LN; Li CG; He X; O'Mara ME; Kantor AB; Nguyen KD
• Mast Cell Repopulating Ability Is Lost During the Transition From Pre-HSC to FL HSC.
  Front Immunol Volume: 13 Page(s): 896396
  01/01/2022 Authors: Yoshimoto M; Kosters A; Cornelius S; Valiente N; Cheng H; Latorre A; Nishida C; Ghosn EEB; Kobayashi M
• Hematopoietic Stem Cell Requirement for Macrophage Regeneration Is Tissue Specific.
  J Immunol Volume: 207 Page(s): 3028 - 3037
  12/15/2021 Authors: Eddins DJ; Kosters A; Waters J; Sosa J; Phillips M; Yadava K; Herzenberg LA; Kuipers HF; Ghosn EEB
• Ultra-selective carbon nanotubes for photoacoustic imaging of inflamed atherosclerotic plaques.
  Adv Funct Mater Volume: 31
  09/09/2021 Authors: Gifani M; Eddins DJ; Kosuge H; Zhang Y; Paluri SLA; Larson T; Leeper N; Herzenberg LA; Gambhir SS; McConnell MV
• Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8+ T Cells during Convalescence.
  J Immunol Volume: 207 Page(s): 1344 - 1356
  09/01/2021 Authors: Ma T; Ryu H; McGregor M; Babcock B; Neidleman J; Xie G; George AF; Frouard J; Murray V; Gill G
• FETAL LIVER HEMATOPOIETIC STEM CELLS POSSESS THE MAST CELL REPOPULATION ABILITY WITHIN A LIMITED TIME WINDOW
  Volume: 100 Page(s): S34 - S34
  08/01/2021 Authors: Kobayashi M; Costers A; Ghosn E; Yoshimoto M
• Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19.
  Cell Rep Volume: 36 Page(s): 109414
  07/20/2021 Authors: Neidleman J; Luo X; George AF; McGregor M; Yang J; Yun C; Murray V; Gill G; Greene WC; Vasquez J
• Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence.
  bioRxiv
  04/29/2021 Authors: Ma T; Ryu H; McGregor M; Babcock B; Neidleman J; Xie G; George AF; Frouard J; Murray V; Gill G
• Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19.
  medRxiv
  02/05/2021 Authors: Neidleman J; Luo X; George AF; McGregor M; Yang J; Yun C; Murray V; Gill G; Greene WC; Vasquez J
• Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.
  Nat Immunol Volume: 21 Page(s): 1506 - 1516
  12/01/2020 Authors: Woodruff MC; Ramonell RP; Nguyen DC; Cashman KS; Saini AS; Haddad NS; Ley AM; Kyu S; Howell JC; Ozturk T
• SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential.
  Cell Rep Med Volume: 1 Page(s): 100081
  09/22/2020 Authors: Neidleman J; Luo X; Frouard J; Xie G; Gill G; Stein ES; McGregor M; Ma T; George AF; Kosters A
• SARS-CoV-2-specific T cells exhibit unique features reflecting robust helper function, lack of terminal differentiation, and high proliferative potential.
  bioRxiv
  08/03/2020 Authors: Neidleman J; Luo X; Frouard J; Xie G; Gill G; Stein ES; McGregor M; Ma T; George A; Kosters A
• Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes.
  J Immunol Volume: 204 Page(s): 3262 - 3272
  06/15/2020 Authors: Kobayashi M; Lin Y; Mishra A; Shelly C; Gao R; Reeh CW; Wang PZ; Xi R; Liu Y; Wenzel P
• A novel dual-reporter lineage tracing model reveals phenotypic and functional heterogeneity of tissue-resident macrophages
  Volume: 204
  05/01/2020 Authors: Eddins DJ; Kosters A; Ghosn EEB
• The class II peptide editor, H2-M, affects the development and repertoire of B-1 cells
  Volume: 204
  05/01/2020 Authors: Ghosh D; Pham TD; He X; O'mara ME; Kantor AB; Khoa N; Sengupta D; Eisenlohr LC; Jensen PE; Herzenberg LA
• Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes.
  Development Volume: 146
  08/01/2019 Authors: Ghosn E; Yoshimoto M; Nakauchi H; Weissman IL; Herzenberg LA
• Automated subset identification and characterization pipeline for multidimensional flow and mass cytometry data clustering and visualization.
  Commun Biol Volume: 2 Page(s): 229
  06/20/2019 Authors: Meehan S; Kolyagin GA; Parks D; Youngyunpipatkul J; Herzenberg LA; Walther G; Ghosn EEB; Orlova DY
• B1 B cell progenitors.
  Science Volume: 364 Page(s): 248
  04/19/2019 Authors: Ghosn E; Dorshkind K; Herzenberg LA; Holodick N; Kantor A; Montecino-Rodriguez E; Rothstein TL; Silverman GJ; Yang Y; Yoder MC
• Automated subset identification and characterization pipeline for multidimensional flow and mass cytometry data clustering and visualization.
  Commun Biol Volume: 2 Page(s): 229
  01/01/2019 Authors: Meehan S; Kolyagin GA; Parks D; Youngyunpipatkul J; Herzenberg LA; Walther G; Ghosn EEB; Orlova DY
• Single-walled carbon nanotubes target neutrophils and Ly-6C(hi) monocytes and localize to joints in murine models of arthritis
  Volume: 200
  05/01/2018 Authors: Hung S-C; Rajasekaran N; Zhu S; Ma Z; Ghosn E; Mellins ED
• HSC-requirement for macrophage regeneration is tissue-specific
  Volume: 200
  05/01/2018 Authors: Ghosn E; Kuipers H; Waters J; Sosa J; Phillips M; Herzenberg LA
• QFMatch: multidimensional flow and mass cytometry samples alignment.
  Sci Rep Volume: 8 Page(s): 3291
  02/19/2018 Authors: Orlova DY; Meehan S; Parks D; Moore WA; Meehan C; Zhao Q; Ghosn EEB; Herzenberg LA; Walther G
• Evidence for altered levels of IgD in the nasal airway mucosa of patients with chronic rhinosinusitis.
  J Allergy Clin Immunol Volume: 140 Page(s): 1562 - 1571.e5
  12/01/2017 Authors: Min J-Y; Nayak JV; Hulse KE; Stevens WW; Raju PA; Huang JH; Suh LA; Van Roey GA; Norton JE; Carter RG
• Of mice and men: HSC transplantation fails to fully regenerate the immune system
  Volume: 46 Page(s): 518 - 518
  08/01/2016 Authors: Ghosn E; Waters J; Phillips M; Yamamoto R; Long B; Yang Y; Gerstein R; Stoddart C; Nakauchi H; Herzenberg L
• Provision of IL-10 by B cells are necessary for the therapeutic efficacy of amyloid fibrils in autoimmune encephalomyelitis
  Volume: 22 Page(s): 31 - 32
  02/01/2016 Authors: Kurnellas MP; Rothbard JB; Ghosn E; Steinman L
• Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment.
  Stem Cell Reports Volume: 6 Page(s): 137 - 149
  01/12/2016 Authors: Ghosn EEB; Waters J; Phillips M; Yamamoto R; Long BR; Yang Y; Gerstein R; Stoddart CA; Nakauchi H; Herzenberg LA
• Earth Mover's Distance (EMD): A True Metric for Comparing Biomarker Expression Levels in Cell Populations.
  PLoS One Volume: 11 Page(s): e0151859
  01/01/2016 Authors: Orlova DY; Zimmerman N; Meehan S; Meehan C; Waters J; Ghosn EEB; Filatenkov A; Kolyagin GA; Gernez Y; Tsuda S
• Amyloid fibrils activate B-1a lymphocytes to ameliorate inflammatory brain disease.
  Proc Natl Acad Sci U S A Volume: 112 Page(s): 15016 - 15023
  12/08/2015 Authors: Kurnellas MP; Ghosn EEB; Schartner JM; Baker J; Rothbard JJ; Negrin RS; Herzenberg LA; Fathman CG; Steinman L; Rothbard JB
• Hematopoietic stem cell-independent B-1a lineage.
  Ann N Y Acad Sci Volume: 1362 Page(s): 23 - 38
  12/01/2015 Authors: Ghosn EEB; Yang Y
• B-1 Cell Development and Function.
  Ann N Y Acad Sci Volume: 1362 Page(s): v - vi
  12/01/2015 Authors: Rothstein TL; Herzenberg LA; Holodick NE; Ghosn E
• Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires.
  Elife Volume: 4 Page(s): e09083
  09/30/2015 Authors: Yang Y; Wang C; Yang Q; Kantor AB; Chu H; Ghosn EE; Qin G; Mazmanian SK; Han J; Herzenberg LA
• HSC-independent lymphopoiesis
  Volume: 194
  05/01/2015 Authors: Ghosn E; Yamamoto R; Phillips M; Waters J; Yang Y; Nakauchi H; Herzenberg L
• Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumour delivery.
  Nat Nanotechnol Volume: 9 Page(s): 481 - 487
  06/01/2014 Authors: Smith BR; Ghosn EEB; Rallapalli H; Prescher JA; Larson T; Herzenberg LA; Gambhir SS
• AutoGate: automating analysis of flow cytometry data.
  Immunol Res Volume: 58 Page(s): 218 - 223
  05/01/2014 Authors: Meehan S; Walther G; Moore W; Orlova D; Meehan C; Parks D; Ghosn E; Philips M; Mitsunaga E; Waters J
• Intracellular localization of myeloperoxidase in murine peritoneal B-lymphocytes and macrophages.
  Cell Immunol Volume: 281 Page(s): 27 - 30
  01/01/2013 Authors: de Araujo TH; Okada SS; Ghosn EEB; Taniwaki NN; Rodrigues MR; de Almeida SR; Mortara RA; Russo M; Campa A; Albuquerque RC
• Reversal of paralysis and reduced inflammation from peripheral administration of -amyloid in TH1 and TH17 versions of experimental autoimmune encephalomyelitis.
  Sci Transl Med Volume: 4 Page(s): 145ra105
  08/01/2012 Authors: Grant JL; Ghosn EEB; Axtell RC; Herges K; Kuipers HF; Woodling NS; Andreasson K; Herzenberg LA; Herzenberg LA; Steinman L
• Antigen-specific memory in B-1a and its relationship to natural immunity.
  Proc Natl Acad Sci U S A Volume: 109 Page(s): 5388 - 5393
  04/03/2012 Authors: Yang Y; Ghosn EEB; Cole LE; Obukhanych TV; Sadate-Ngatchou P; Vogel SN; Herzenberg LA; Herzenberg LA
• Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells.
  Proc Natl Acad Sci U S A Volume: 109 Page(s): 5394 - 5398
  04/03/2012 Authors: Ghosn EEB; Yamamoto R; Hamanaka S; Yang Y; Herzenberg LA; Nakauchi H; Herzenberg LA
• Antigen-specific antibody responses in B-1a and their relationship to natural immunity.
  Proc Natl Acad Sci U S A Volume: 109 Page(s): 5382 - 5387
  04/03/2012 Authors: Yang Y; Ghosn EEB; Cole LE; Obukhanych TV; Sadate-Ngatchou P; Vogel SN; Herzenberg LA; Herzenberg LA
• Development of B cells and erythrocytes is specifically impaired by the drug celastrol in mice.
  PLoS One Volume: 7 Page(s): e35733
  01/01/2012 Authors: Kusy S; Ghosn EEB; Herzenberg LA; Contag CH
• Distinct progenitors for B-1 and B-2 cells are present in adult mouse spleen.
  Proc Natl Acad Sci U S A Volume: 108 Page(s): 2879 - 2884
  02/15/2011 Authors: Ghosn EEB; Sadate-Ngatchou P; Yang Y; Herzenberg LA; Herzenberg LA
• Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy.
  Int Arch Allergy Immunol Volume: 154 Page(s): 318 - 327
  01/01/2011 Authors: Gernez Y; Tirouvanziam R; Yu G; Ghosn EEB; Reshamwala N; Nguyen T; Tsai M; Galli SJ; Herzenberg LA; Herzenberg LA
• Cellular renewal and improvement of local cell effector activity in peritoneal cavity in response to infectious stimuli.
  PLoS One Volume: 6 Page(s): e22141
  01/01/2011 Authors: Cassado ADA; de Albuquerque JAT; Sardinha LR; Buzzo CDL; Faustino L; Nascimento R; Ghosn EEB; Lima MRD; Alvarez JMM; Bortoluci KR
• Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy
  Volume: 65 Page(s): 503 - 503
  06/01/2010 Authors: Gernez Y; Yu G; Ghosn E; Tsai M; Galli S; Herzenberg L; Tirouvanziam R; Nadeau K
• Two physically, functionally, and developmentally distinct peritoneal macrophage subsets.
  Proc Natl Acad Sci U S A Volume: 107 Page(s): 2568 - 2573
  02/09/2010 Authors: Ghosn EEB; Cassado AA; Govoni GR; Fukuhara T; Yang Y; Monack DM; Bortoluci KR; Almeida SR; Herzenberg LA; Herzenberg LA
• Monocyte-derived dendritic cells from patients with severe forms of chromoblastomycosis induce CD4+ T cell activation in vitro.
  Clin Exp Immunol Volume: 156 Page(s): 117 - 125
  04/01/2009 Authors: Sousa MG; Ghosn EEB; Nascimento RC; Bomfim GF; Noal V; Santiago K; de Maria Pedrozo E Silva Azevedo C; Marques SG; Gonalves AG; de Castro Lima Santos DW
• Fonsecaea pedrosoi infection induces differential modulation of costimulatory molecules and cytokines in monocytes from patients with severe and mild forms of chromoblastomycosis.
  J Leukoc Biol Volume: 84 Page(s): 864 - 870
  09/01/2008 Authors: Sousa MGT; de Maria Pedrozo e Silva Azevedo C; Nascimento RC; Ghosn EEB; Santiago KL; Noal V; Bomfim GF; Marques SG; Gonalves AG; Wagner de Castro Lima Santos D
• CD11b expression distinguishes sequential stages of peritoneal B-1 development.
  Proc Natl Acad Sci U S A Volume: 105 Page(s): 5195 - 5200
  04/01/2008 Authors: Ghosn EEB; Yang Y; Tung J; Herzenberg LA; Herzenberg LA
• Division and differentiation of natural antibody-producing cells in mouse spleen.
  Proc Natl Acad Sci U S A Volume: 104 Page(s): 4542 - 4546
  03/13/2007 Authors: Yang Y; Tung JW; Ghosn EEB; Herzenberg LA; Herzenberg LA
• Absence of CD4+ T cells impairs host defence of mice infected with Fonsecaea pedrosoi.
  Scand J Immunol Volume: 64 Page(s): 595 - 600
  12/01/2006 Authors: Teixeira de Sousa MDG; Ghosn EEB; Almeida SR
• Phagocytosis, production of nitric oxide and pro-inflammatory cytokines by macrophages in the presence of dematiaceous [correction of dematiaceus] fungi that cause chromoblastomycosis.
  Scand J Immunol Volume: 64 Page(s): 382 - 387
  10/01/2006 Authors: Hayakawa M; Ghosn EEB; da Gloria Teixeria de Sousa M; Ferreira KS; Almeida SR
• Nitric oxide-dependent killing of Cryptococcus neoformans by B-1-derived mononuclear phagocyte.
  J Leukoc Biol Volume: 80 Page(s): 36 - 44
  07/01/2006 Authors: Ghosn EEB; Russo M; Almeida SR