Publications

• Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer.
  Nat Commun Volume: 16 Page(s): 2324
  03/08/2025 Authors: Shu C; Li J; Rui J; Fan D; Niu Q; Bai R; Cicka D; Doyle S; Wahafu A; Zheng X
• Improving glioma drug delivery: A multifaceted approach for glioma drug development.
  Pharmacol Res Volume: 208 Page(s): 107390
  10/01/2024 Authors: Yonk MG; Lim MA; Thompson CM; Tora MS; Lakhina Y; Du Y; Hoang KB; Molinaro AM; Boulis NM; Hassaneen W
• Development of a time-resolved fluorescence resonance energy transfer ultra-high throughput screening assay targeting SYK and FCER1G interaction.
  SLAS Discov Volume: 29 Page(s): 100177
  09/01/2024 Authors: Du Y; Wang D; Katis VL; Zoeller EL; Qui M; Levey AI; Gileadi O; Fu H; Emory-SAGE-SGC TREAT-AD Center
• A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting the SMAD4-SMAD3-DNA complex.
  J Mol Cell Biol Volume: 15
  04/10/2024 Authors: Ouyang W; Li Q; Niu Q; Qui M; Fu H; Du Y; Mo X
• Frequency-potency analysis of IgG+ memory B cells delineates neutralizing antibody responses at single-cell resolution.
  Cell Rep Volume: 43 Page(s): 113948
  03/26/2024 Authors: Tenggara MK; Oh S-H; Yang C; Nariya HK; Metz AM; Upadhyay AA; Gudipati DR; Guo L; McGhee EG; Gill K
• Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
  PLoS One Volume: 19 Page(s): e0293548
  01/01/2024 Authors: Bashore FM; Katis VL; Du Y; Sikdar A; Wang D; Bradshaw WJ; Rygiel KA; Leisner TM; Chalk R; Mishra S
• Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
  J Biol Chem Volume: 299 Page(s): 105382
  12/01/2023 Authors: Du Y; Bradshaw WJ; Leisner TM; Annor-Gyamfi JK; Qian K; Bashore FM; Sikdar A; Nwogbo FO; Ivanov AA; Frye SV
• Fused Tetrahydroquinolines Are Interfering with Your Assay.
  J Med Chem Volume: 66 Page(s): 14434 - 14446
  11/09/2023 Authors: Bashore FM; Annor-Gyamfi J; Du Y; Katis V; Nwogbo F; Flax RG; Frye SV; Pearce KH; Fu H; Willson TM
• A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis.
  ACS Med Chem Lett Volume: 14 Page(s): 1338 - 1343
  10/12/2023 Authors: Rab A; Yang X; Tracy WF; Hong JS; Joshi D; Manfredi C; Ponnaluri SS; Kolykhalov AA; Qui M; Fu H
• Tumor microenvironment in a minipig model of spinal cord glioma.
  J Transl Med Volume: 21 Page(s): 667
  09/27/2023 Authors: Tora MS; Neill SG; Lakhina Y; Assed H; Zhang M; Nagarajan PP; Federici T; Gutierrez J; Hoang KB; Du Y
• Constitutively Synergistic Multiagent Drug Formulations Targeting MERTK, FLT3, and BCL-2 for Treatment of AML.
  Pharm Res Volume: 40 Page(s): 2133 - 2146
  09/01/2023 Authors: Kelvin JM; Jain J; Thapa A; Qui M; Birnbaum LA; Moore SG; Zecca H; Summers RJ; Switchenko JM; Costanza E
• Development of constitutively synergistic nanoformulations to enhance chemosensitivity in T-cell leukemia.
  J Control Release Volume: 361 Page(s): 470 - 482
  09/01/2023 Authors: Kelvin JM; Chimenti ML; Zhang DY; Williams EK; Moore SG; Humber GM; Baxter TA; Birnbaum LA; Qui M; Zecca H
• Nicardipine is a putative EED inhibitor and has high selectivity and potency against chemoresistant prostate cancer in preclinical models.
  Br J Cancer Volume: 129 Page(s): 884 - 894
  09/01/2023 Authors: Li X; Chen Y; Bai L; Zhao R; Wu Y; Xie Z-R; Wu JM; Bowen NJ; Danaher A; Cook N
• TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS.
  J Mol Cell Biol Volume: 15
  08/03/2023 Authors: Cicka D; Niu Q; Qui M; Qian K; Miller E; Fan D; Mo X; Ivanov AA; Sarafianos SG; Du Y
• Bromocriptine monotherapy overcomes prostate cancer chemoresistance in preclinical models.
  Transl Oncol Volume: 34 Page(s): 101707
  08/01/2023 Authors: Bai L; Li X; Yang Y; Zhao R; White EZ; Danaher A; Bowen NJ; Hinton CV; Cook N; Li D
• Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
  bioRxiv
  07/29/2023 Authors: Bashore FM; Katis VL; Du Y; Sikdar A; Wang D; Bradshaw WJ; Rygiel KA; Leisner TM; Chalk R; Mishra S
• Cyclosporines Antagonize the Antiviral Activity of IFITMProteins by Redistributing Them toward the Golgi Apparatus.
  Biomolecules Volume: 13
  06/03/2023 Authors: Prikryl D; Marin M; Desai TM; Du Y; Fu H; Melikyan GB
• Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer's disease.
  bioRxiv
  05/22/2023 Authors: Du Y; Bradshaw WJ; Leisner TM; Annor-Gyamfi JK; Qian K; Bashore FM; Sikdar A; Nwogbo FO; Ivanov AA; Frye SV
• High-throughput screening strategies for space-based radiation countermeasure discovery.
  Life Sci Space Res (Amst) Volume: 35 Page(s): 88 - 104
  11/01/2022 Authors: Putt KS; Du Y; Fu H; Zhang Z-Y
• Correction for Puckett et al., "Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-IB Kinase Cascade".
  Mol Cell Biol Volume: 42 Page(s): e0028222
  10/20/2022 Authors: Puckett MC; Goldman EH; Cockrell LM; Huang B; Kasinski AL; Du Y; Wang C-Y; Lin A; Ichijo H; Khuri F
• Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells.
  Acta Pharmacol Sin Volume: 43 Page(s): 2419 - 2428
  09/01/2022 Authors: Shu C; Zheng X; Wuhafu A; Cicka D; Doyle S; Niu Q; Fan D; Qian K; Ivanov AA; Du Y
• Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
  Cell Volume: 185 Page(s): 1974 - 1985.e12
  05/26/2022 Authors: Mo X; Niu Q; Ivanov AA; Tsang YH; Tang C; Shu C; Li Q; Qian K; Wahafu A; Doyle SP
• A time-resolved fluorescence resonance energy transfer screening assay for discovery of protein-protein interaction modulators.
  STAR Protoc Volume: 2 Page(s): 100804
  09/17/2021 Authors: Tang C; Niu Q; Cicka D; Du Y; Mo X; Fu H
• Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer.
  Bioorg Med Chem Volume: 45 Page(s): 116324
  09/01/2021 Authors: Yang X; Fan D; Troha AH; Ahn HM; Qian K; Liang B; Du Y; Fu H; Ivanov AA
• A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation.
  Cancer Discov Volume: 11 Page(s): 1562 - 1581
  06/01/2021 Authors: Lo Y-H; Kolahi KS; Du Y; Chang C-Y; Krokhotin A; Nair A; Sobba WD; Karlsson K; Jones SJ; Longacre TA
• Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF- signaling.
  Cell Chem Biol Volume: 28 Page(s): 636 - 647.e5
  05/20/2021 Authors: Tang C; Mo X; Niu Q; Wahafu A; Yang X; Qui M; Ivanov AA; Du Y; Fu H
• An expanded universe of cancer targets.
  Cell Volume: 184 Page(s): 1142 - 1155
  03/04/2021 Authors: Hahn WC; Bader JS; Braun TP; Califano A; Clemons PA; Druker BJ; Ewald AJ; Fu H; Jagu S; Kemp CJ
• Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer.
  Theranostics Volume: 11 Page(s): 6873 - 6890
  01/01/2021 Authors: Li X; Gera L; Zhang S; Chen Y; Lou L; Wilson LM; Xie Z-R; Sautto G; Liu D; Danaher A
• Melphalan induces cardiotoxicity through oxidative stress in cardiomyocytes derived from human induced pluripotent stem cells.
  Stem Cell Res Ther Volume: 11 Page(s): 470
  11/05/2020 Authors: Liu R; Li D; Sun F; Rampoldi A; Maxwell JT; Wu R; Fischbach P; Castellino SM; Du Y; Fu H
• Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma.
  J Hematol Oncol Volume: 13 Page(s): 141
  10/21/2020 Authors: Lei K; Gu X; Alvarado AG; Du Y; Luo S; Ahn EH; Kang SS; Ji B; Liu X; Mao H
• High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients.
  J Transl Med Volume: 18 Page(s): 334
  09/01/2020 Authors: Yang X; Amgad M; Cooper LAD; Du Y; Fu H; Ivanov AA
• Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening.
  J Mol Cell Biol Volume: 12 Page(s): 630 - 643
  08/01/2020 Authors: Du Y; Li X; Niu Q; Mo X; Qui M; Ma T; Kuo CJ; Fu H
• NSD3S stabilizes MYC through hindering its interaction with FBXW7.
  J Mol Cell Biol Volume: 12 Page(s): 438 - 447
  07/03/2020 Authors: Gonzalez-Pecchi V; Kwan AK; Doyle S; Ivanov AA; Du Y; Fu H
• Human beige adipocytes for drug discovery and cell therapy in metabolic diseases.
  Nat Commun Volume: 11 Page(s): 2758
  06/02/2020 Authors: Singh AM; Zhang L; Avery J; Yin A; Du Y; Wang H; Li Z; Fu H; Yin H; Dalton S
• Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion.
  Nat Commun Volume: 11 Page(s): 1533
  03/24/2020 Authors: Commander R; Wei C; Sharma A; Mouw JK; Burton LJ; Summerbell E; Mahboubi D; Peterson RJ; Konen J; Zhou W
• Discovery and targeting MKK3-MYC protein-protein interaction for therapeutic interrogation in cancer
  Volume: 79
  07/01/2019 Authors: Yang X; Du Y; Fu H; Ivanov AA
• HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers.
  Cell Chem Biol Volume: 26 Page(s): 331 - 339.e3
  03/21/2019 Authors: Mo X; Tang C; Niu Q; Ma T; Du Y; Fu H
• Repositioning Dopamine D2 Receptor Agonist Bromocriptine to Enhance Docetaxel Chemotherapy and Treat Bone Metastatic Prostate Cancer.
  Mol Cancer Ther Volume: 17 Page(s): 1859 - 1870
  09/01/2018 Authors: Yang Y; Mamouni K; Li X; Chen Y; Kavuri S; Du Y; Fu H; Kucuk O; Wu D
• Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening.
  Sci Rep Volume: 8 Page(s): 10210
  07/05/2018 Authors: Mady ASA; Liao C; Bajwa N; Kump KJ; Abulwerdi FA; Lev KL; Miao L; Grigsby SM; Perdih A; Stuckey JA
• Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.
  ACS Chem Biol Volume: 13 Page(s): 933 - 941
  04/20/2018 Authors: Huard DJE; Crowley VM; Du Y; Cordova RA; Sun Z; Tomlin MO; Dickey CA; Koren J; Blair L; Fu H
• The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target discovery.
  Bioinformatics Volume: 34 Page(s): 1183 - 1191
  04/01/2018 Authors: Ivanov AA; Revennaugh B; Rusnak L; Gonzalez-Pecchi V; Mo X; Johns MA; Du Y; Cooper LAD; Moreno CS; Khuri FR
• Development of a Time-Resolved Fluorescence Resonance Energy Transfer Ultrahigh-Throughput Screening Assay for Targeting the NSD3 and MYC Interaction.
  Assay Drug Dev Technol Volume: 16 Page(s): 96 - 106
  01/01/2018 Authors: Xiong J; Pecchi VG; Qui M; Ivanov AA; Mo X; Niu Q; Chen X; Fu H; Du Y
• OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc.
  Oncogene Volume: 36 Page(s): 5852 - 5860
  10/19/2017 Authors: Ivanov AA; Gonzalez-Pecchi V; Khuri LF; Niu Q; Wang Y; Xu Y; Bai Y; Mo X; Prochownik EV; Johns MA
• PRAS40 promotes NF-B transcriptional activity through association with p65.
  Oncogenesis Volume: 6 Page(s): e381
  09/25/2017 Authors: Zhu G; Qi Q; Havel JJ; Li Z; Du Y; Zhang X; Fu H
• Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.
  J Med Chem Volume: 60 Page(s): 7244 - 7255
  09/14/2017 Authors: Qi Q; Obianyo O; Du Y; Fu H; Li S; Ye K
• Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype.
  Oncogene Volume: 36 Page(s): 4224 - 4232
  07/20/2017 Authors: Guo X; Koff JL; Moffitt AB; Cinar M; Ramachandiran S; Chen Z; Switchenko JM; Mosunjac M; Neill SG; Mann KP
• Aurora kinase A interacts with H-Ras and potentiates Ras-MAPK signaling.
  Oncotarget Volume: 8 Page(s): 28359 - 28372
  04/25/2017 Authors: Umstead M; Xiong J; Qi Q; Du Y; Fu H
• Corrigendum: The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
  Nat Commun Volume: 8 Page(s): 15350
  04/18/2017 Authors: Li Z; Ivanov AA; Su R; Gonzalez-Pecchi V; Qi Q; Liu S; Webber P; McMillan E; Rusnak L; Pham C
• AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc-Based Protein-Fragment Complementation Assay.
  Mol Pharmacol Volume: 91 Page(s): 339 - 347
  04/01/2017 Authors: Mo X; Qi Q; Ivanov AA; Niu Q; Luo Y; Havel J; Goetze R; Bell S; Moreno CS; Cooper LAD
• Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
  Nat Commun Volume: 8 Page(s): 14740
  03/27/2017 Authors: Zhang Z; Obianyo O; Dall E; Du Y; Fu H; Liu X; Kang SS; Song M; Yu S-P; Cabrele C
• The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
  Nat Commun Volume: 8 Page(s): 14356
  02/16/2017 Authors: Li Z; Ivanov AA; Su R; Gonzalez-Pecchi V; Qi Q; Liu S; Webber P; McMillan E; Rusnak L; Pham C
• Screening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors.
  Assay Drug Dev Technol Volume: 15 Page(s): 53 - 63
  01/01/2017 Authors: Giroud C; Du Y; Marin M; Min Q; Jui NT; Fu H; Melikyan GB
• MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development.
  PLoS One Volume: 12 Page(s): e0170339
  01/01/2017 Authors: Harati S; Cooper LAD; Moran JD; Giuste FO; Du Y; Ivanov AA; Johns MA; Khuri FR; Fu H; Moreno CS
• Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment.
  Cancer Cell Volume: 30 Page(s): 623 - 636
  10/10/2016 Authors: Gu L; Zhang H; Liu T; Zhou S; Du Y; Xiong J; Yi S; Qu C-K; Fu H; Zhou M
• Enabling systematic interrogation of protein-protein interactions in live cells with a versatile ultra-high-throughput biosensor platform.
  J Mol Cell Biol Volume: 8 Page(s): 271 - 281
  06/01/2016 Authors: Mo X-L; Luo Y; Ivanov AA; Su R; Havel JJ; Li Z; Khuri FR; Du Y; Fu H
• Predicting the essentialities of protein-protein interactions in cancer
  CANCER RESEARCH Volume: 75
  11/15/2015 Authors: Cooper LAD; Moran JD; Li Z; Du Y; Harati S; Ivanov AA; Webber P; Havel JJ; Johns MA; Fu H
• Downregulation of urea transporter UT-A1 activity by 14-3-3 protein.
  Am J Physiol Renal Physiol Volume: 309 Page(s): F71 - F78
  07/01/2015 Authors: Feng X; Li Z; Du Y; Fu H; Klein JD; Cai H; Sands JM; Chen G
• Chromosome instability in diffuse large B cell lymphomas is suppressed by activation of the noncanonical NF-B pathway.
  Int J Cancer Volume: 136 Page(s): 2341 - 2351
  05/15/2015 Authors: Ramachandiran S; Adon A; Guo X; Wang Y; Wang H; Chen Z; Kowalski J; Sunay UR; Young AN; Brown T
• Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3.
  Oncogene Volume: 34 Page(s): 2538 - 2545
  05/07/2015 Authors: Shi Z; Li Z; Li ZJ; Cheng K; Du Y; Fu H; Khuri FR
• High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors.
  Assay Drug Dev Technol Volume: 13 Page(s): 155 - 166
  04/01/2015 Authors: Marin M; Du Y; Giroud C; Kim JH; Qui M; Fu H; Melikyan GB
• Stress induces p38 MAPK-mediated phosphorylation and inhibition of Drosha-dependent cell survival.
  Mol Cell Volume: 57 Page(s): 721 - 734
  02/19/2015 Authors: Yang Q; Li W; She H; Dou J; Duong DM; Du Y; Yang S-H; Seyfried NT; Fu H; Gao G
• Cables1 complex couples survival signaling to the cell death machinery.
  Cancer Res Volume: 75 Page(s): 147 - 158
  01/01/2015 Authors: Shi Z; Park HR; Du Y; Li Z; Cheng K; Sun S-Y; Li Z; Fu H; Khuri FR
• Fluorescence polarization assay to quantify protein-protein interactions in an HTS format.
  Methods Mol Biol Volume: 1278 Page(s): 529 - 544
  01/01/2015 Authors: Du Y
• Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.
  Oncoscience Volume: 2 Page(s): 765 - 776
  01/01/2015 Authors: Webber PJ; Park C; Qui M; Ramalingam SS; Khuri FR; Fu H; Du Y
• Synthesis and evaluation of bisbenzylidenedioxotetrahydrothiopranones as activators of endoplasmic reticulum (ER) stress signaling pathways and apoptotic cell death in acute promyelocytic leukemic cells.
  J Med Chem Volume: 57 Page(s): 5904 - 5918
  07/24/2014 Authors: Tan K-L; Ali A; Du Y; Fu H; Jin H-X; Chin T-M; Khan M; Go M-L
• Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs.
  Oncotarget Volume: 5 Page(s): 3197 - 3209
  05/30/2014 Authors: Li Z; Park HR; Shi Z; Li Z; Pham CD; Du Y; Khuri FR; Zhang Y; Han Q; Fu H
• The Emory Chemical Biology Discovery Center: leveraging academic innovation to advance novel targets through HTS and beyond.
  Comb Chem High Throughput Screen Volume: 17 Page(s): 290 - 296
  03/01/2014 Authors: Johns MA; Meyerkord-Belton CL; Du Y; Fu H
• Ligands for glaucoma-associated myocilin discovered by a generic binding assay.
  ACS Chem Biol Volume: 9 Page(s): 517 - 525
  02/21/2014 Authors: Orwig SD; Chi PV; Du Y; Hill SE; Cavitt MA; Suntharalingam A; Turnage KC; Dickey CA; France S; Fu H
• Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma (vol 11, pg 4757, 2013)
  ORGANIC & BIOMOLECULAR CHEMISTRY Volume: 11 Page(s): 8511 - 8511
  12/28/2013 Authors: Liu K; Zhang D; Chojnacki J; Du Y; Wu J; Fu H; Grant S; Zhang S
• Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma.
  Org Biomol Chem Volume: 11 Page(s): 4757 - 4763
  08/07/2013 Authors: Liu K; Zhang D; Chojnacki J; Du Y; Fu H; Grant S; Zhang S
• Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models.
  Biochem Pharmacol Volume: 86 Page(s): 351 - 360
  08/01/2013 Authors: Zhang Q; Zhai S; Li L; Li X; Zhou H; Liu A; Su G; Mu Q; Du Y; Yan B
• A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors.
  Assay Drug Dev Technol Volume: 11 Page(s): 367 - 381
  07/01/2013 Authors: Du Y; Fu RW; Lou B; Zhao J; Qui M; Khuri FR; Fu H
• Integration of apoptosis signal-regulating kinase 1-mediated stress signaling with the Akt/protein kinase B-IB kinase cascade.
  Mol Cell Biol Volume: 33 Page(s): 2252 - 2259
  06/01/2013 Authors: Puckett MC; Goldman EH; Cockrell LM; Huang B; Kasinski AL; Du Y; Wang C-Y; Lin A; Ichijo H; Khuri F
• Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway.
  Oncol Rep Volume: 29 Page(s): 430 - 436
  02/01/2013 Authors: Chen M; Du Y; Qui M; Wang M; Chen K; Huang Z; Jiang M; Xiong F; Chen J; Zhou J
• Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits.
  Chem Biol Volume: 19 Page(s): 752 - 763
  06/22/2012 Authors: Smith SME; Min J; Ganesh T; Diebold B; Kawahara T; Zhu Y; McCoy J; Sun A; Snyder JP; Fu H
• Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis.
  Bioorg Med Chem Lett Volume: 22 Page(s): 4179 - 4181
  06/15/2012 Authors: Yan Y-M; Dai H-Q; Du Y; Schneider B; Guo H; Li D-P; Zhang L-X; Fu H; Dong X-P; Cheng Y-X
• An endogenous mTOR inhibitor, PRAS40, is upregulated in lung cancer and contributes to tumor cell invasion and chemoresistance
  CANCER RESEARCH Volume: 72
  04/15/2012 Authors: Li Z; Du Y; Sica G; Ramalingam SS; Gal AA; Pan L; Tighiouart MM; Khuri FRFR; Fu H
• 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.
  DNA Repair (Amst) Volume: 11 Page(s): 267 - 277
  03/01/2012 Authors: Andersen SD; Keijzers G; Rampakakis E; Engels K; Luhn P; El-Shemerly M; Nielsen FC; Du Y; May A; Bohr VA
• Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.
  Proc Natl Acad Sci U S A Volume: 109 Page(s): 3149 - 3154
  02/21/2012 Authors: Jiang J; Ganesh T; Du Y; Quan Y; Serrano G; Qui M; Speigel I; Rojas A; Lelutiu N; Dingledine R
• Label-Free Resonant Waveguide Grating (RWG) Biosensor Technology for Noninvasive Detection of Oncogenic Signaling Pathways in Cancer Cells
  Page(s): 171 - 184
  01/01/2012 Authors: Du Y; Qui M; Fu H
• Truncation of NF-KB2 Is Associated with Poor Response to Bortezomib Treatment in Multiple Myeloma
  Volume: 118 Page(s): 1248 - 1248
  11/18/2011 Authors: Ramachandiran S; Guo X; Garderet L; Ikhlef S; El-cheikh J; Weil MR; Young AN; Bagirov M; Lonial S; Chen Z
• Ebselen Congeners Inhibit NADPH-oxidase 2 (Nox2)-Dependent Superoxide Generation by Interrupting the Binding of Regulatory Subunits
  Volume: 51 Page(s): S98 - S98
  11/01/2011 Authors: Smith SME; Min J; Ganesh T; Kawahara T; Diebold B; Zhu Y; McCoy J; Sun A; Snyder JP; Fu H
• Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.
  Proc Natl Acad Sci U S A Volume: 108 Page(s): 16212 - 16216
  09/27/2011 Authors: Zhao J; Du Y; Horton JR; Upadhyay AK; Lou B; Bai Y; Zhang X; Du L; Li M; Wang B
• 14-3-3 proteins as potential therapeutic targets.
  Semin Cell Dev Biol Volume: 22 Page(s): 705 - 712
  09/01/2011 Authors: Zhao J; Meyerkord CL; Du Y; Khuri FR; Fu H
• A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin.
  J Biomol Screen Volume: 16 Page(s): 836 - 844
  09/01/2011 Authors: Li L; Du Y; Chen W; Fu H; Harrison DG
• A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.
  Assay Drug Dev Technol Volume: 9 Page(s): 382 - 393
  08/01/2011 Authors: Du Y; Nikolovska-Coleska Z; Qui M; Li L; Lewis I; Dingledine R; Stuckey JA; Krajewski K; Roller PP; Wang S
• Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.
  J Virol Volume: 85 Page(s): 6381 - 6389
  07/01/2011 Authors: Cencic R; Desforges M; Hall DR; Kozakov D; Du Y; Min J; Dingledine R; Fu H; Vajda S; Talbot PJ
• The Cables1 protein complex couples survival signaling to cell death machinery
  CANCER RESEARCH Volume: 71
  04/15/2011 Authors: Shi Z; Park HR; Du Y; Fu H; Khuri FR
• Discovering small-molecule estrogen receptor /coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency.
  ChemMedChem Volume: 6 Page(s): 654 - 666
  04/04/2011 Authors: Sun A; Moore TW; Gunther JR; Kim M-S; Rhoden E; Du Y; Fu H; Snyder JP; Katzenellenbogen JA
• Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.
  Proc Natl Acad Sci U S A Volume: 108 Page(s): 1046 - 1051
  01/18/2011 Authors: Cencic R; Hall DR; Robert F; Du Y; Min J; Li L; Qui M; Lewis I; Kurtkaya S; Dingledine R
• Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-B signaling pathway.
  J Med Chem Volume: 53 Page(s): 8260 - 8273
  12/09/2010 Authors: Qiu X; Du Y; Lou B; Zuo Y; Shao W; Huo Y; Huang J; Yu Y; Zhou B; Du J
• Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy.
  Biochem Pharmacol Volume: 80 Page(s): 1309 - 1316
  11/01/2010 Authors: Thomas SL; Zhao J; Li Z; Lou B; Du Y; Purcell J; Snyder JP; Khuri FR; Liotta D; Fu H
• Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
  J Pharmacol Exp Ther Volume: 333 Page(s): 650 - 662
  06/01/2010 Authors: Hansen KB; Mullasseril P; Dawit S; Kurtkaya NL; Yuan H; Vance KM; Orr AG; Kvist T; Ogden KK; Le P
• Monitoring GTPCH-1 Interaction with GFRP Using Time-Resolved Fluorescence Resonance Energy Transfer
  FASEB JOURNAL Volume: 24
  04/01/2010 Authors: Li L; Du Y; Fu H; Salerno JC; Chen W; Harrison DG
• Small molecule inhibitors of estrogen receptor a/coactivator binding: Synthesis and in vitro and cell-based biological evaluation
  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 239
  03/21/2010 Authors: Sun A; Moore T; Gunther JR; Kim M-S; Rhoden E; Du Y; Fu H; Snyder JP; Katzenellenbogen JA
• Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.
  Proc Natl Acad Sci U S A Volume: 107 Page(s): 2307 - 2312
  02/02/2010 Authors: Jiang J; Ganesh T; Du Y; Thepchatri P; Rojas A; Lewis I; Kurtkaya S; Li L; Qui M; Serrano G
• Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.
  Mol Cell Volume: 34 Page(s): 497 - 509
  05/14/2009 Authors: Aslan JE; You H; Williamson DM; Endig J; Youker RT; Thomas L; Shu H; Du Y; Milewski RL; Brush MH
• Anticancer activity profiling of a panel of curcumin analogues in head and neck and lung cancer cells
  CANCER RESEARCH Volume: 69
  05/01/2009 Authors: Lou B; Du Y; Kasinski A; Thomas S; Sun A; Sun S-Y; Chen G; Shin D; Khuri F; Liotta D
• Label-free biosensor technology for monitoring oncogenic signaling pathways
  CANCER RESEARCH Volume: 69
  05/01/2009 Authors: Du Y; Zhao J; Chen ZG; Shin DM; Khui FR; Fu H
• Anticancer activity profiling of a panel of curcumin analogues in head and neck and lung cancer cells
  CANCER RESEARCH Volume: 69
  05/01/2009 Authors: Iou B; Du Y; Kasinski A; Thomas S; Sun A; Sun S-Y; Chen G; Shin D; Khuri F; Liotta D
• Discovery of novel angiogenesis inhibitors using transgenic zebrafish as a high-throughput phenotypic screening model
  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 237
  03/22/2009 Authors: Min J; Kurtkaya S; Sneed B; Du Y; Sandberg EM; Baranowski TC; Sun A; Snyder JP; Liotta DC; Dingledine R
• Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening.
  Mol Cancer Ther Volume: 8 Page(s): 563 - 570
  03/01/2009 Authors: Bialkowska AB; Du Y; Fu H; Yang VW
• A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding.
  J Biomol Screen Volume: 14 Page(s): 181 - 193
  02/01/2009 Authors: Gunther JR; Du Y; Rhoden E; Lewis I; Revennaugh B; Moore TW; Kim SH; Dingledine R; Fu H; Katzenellenbogen JA
• Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells.
  J Recept Signal Transduct Res Volume: 29 Page(s): 182 - 194
  01/01/2009 Authors: Du Y; Li Z; Li L; Chen ZG; Sun S-Y; Chen P; Shin DM; Khuri FR; Fu H
• Cancer and virus leads by HTS, chemical design and SEA data mining.
  Curr Top Med Chem Volume: 9 Page(s): 1159 - 1171
  01/01/2009 Authors: Thepchatri P; Min J; Ganesh T; Du Y; Lewis I; Kurtkaya S; Prussia A; Li L; Sneed B; Plemper RK
• A homogenous luminescent proximity assay for 14-3-3 interactions with both phosphorylated and nonphosphorylated client peptides.
  Curr Chem Genomics Volume: 2 Page(s): 40 - 47
  11/06/2008 Authors: Du Y; Khuri FR; Fu H
• Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay.
  Bioorg Med Chem Lett Volume: 18 Page(s): 4982 - 4987
  09/15/2008 Authors: Ganesh T; Thepchatri P; Li L; Du Y; Fu H; Snyder JP; Sun A
• Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.
  Mol Pharmacol Volume: 74 Page(s): 654 - 661
  09/01/2008 Authors: Kasinski AL; Du Y; Thomas SL; Zhao J; Sun S-Y; Khuri FR; Wang C-Y; Shoji M; Sun A; Snyder JP
• High-throughput screening-based identification of paramyxovirus inhibitors.
  J Biomol Screen Volume: 13 Page(s): 591 - 608
  08/01/2008 Authors: Yoon J-J; Chawla D; Paal T; Ndungu M; Du Y; Kurtkaya S; Sun A; Snyder JP; Plemper RK
• Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.
  Bioorg Med Chem Volume: 16 Page(s): 6903 - 6910
  07/15/2008 Authors: Ganesh T; Min J; Thepchatri P; Du Y; Li L; Lewis I; Wilson L; Fu H; Chiosis G; Dingledine R
• Role of 14-3-3zeta in Anoikis Resistance and Anchorage-independent Growth of Lung Cancer Cells
  FASEB JOURNAL Volume: 22
  04/01/2008 Authors: Zhao J; Li Z; Du Y; Park HR; Sun S-Y; Khuri F; Fu H
• Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation.
  Proc Natl Acad Sci U S A Volume: 105 Page(s): 162 - 167
  01/08/2008 Authors: Li Z; Zhao J; Du Y; Park HR; Sun S-Y; Bernal-Mizrachi L; Aitken A; Khuri FR; Fu H
• High-throughput screening fluorescence polarization assay for tumor-specific Hsp90.
  J Biomol Screen Volume: 12 Page(s): 915 - 924
  10/01/2007 Authors: Du Y; Moulick K; Rodina A; Aguirre J; Felts S; Dingledine R; Fu H; Chiosis G
• Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity.
  Antimicrob Agents Chemother Volume: 51 Page(s): 2293 - 2303
  07/01/2007 Authors: White LK; Yoon J-J; Lee JK; Sun A; Du Y; Fu H; Snyder JP; Plemper RK
• cAMP/adenylyl cyclase stimulation promotes 14-3-3 binding to UT-A1 urea transporter
  Volume: 21 Page(s): A906 - A906
  04/01/2007 Authors: Chen G; Li Z; Klein JD; Yang Y; Frhlich O; Du Y; Fu H; Sands JM
• Targeting protein-protein interactions in signaling pathways for therapeutic interventions
  ACTA PHARMACOLOGICA SINICA Volume: 27 Page(s): 26 - 26
  07/01/2006 Authors: Du Y; Luhn P; Park H; Sun S; Khuri FR; Fu H
• Arsenic trioxide induced a caspase-independent cell death involving downregulation of Bclxl in cisplatin resistant ovarian cancer cell line - OVCAR-3
  Volume: 66
  04/01/2006 Authors: Ong P-S; Du Y; Chan S-Y; Ho PC
• Monitoring 14-3-3 protein interactions with a homogeneous fluorescence polarization assay.
  J Biomol Screen Volume: 11 Page(s): 269 - 276
  04/01/2006 Authors: Du Y; Masters SC; Khuri FR; Fu H
• Arsenic compounds induce cytotoxicity and apoptosis in cisplatin-sensitive and -resistant gynecological cancer cell lines.
  Cancer Chemother Pharmacol Volume: 47 Page(s): 481 - 490
  06/01/2001 Authors: Du YH; Ho PC