Publications

• Discovery of Novel TYRO3/MERTK Dual Inhibitors.
  J Med Chem Volume: 68 Page(s): 8455 - 8470
  04/24/2025 Authors: Kong D; Zhao J; Huang D; Stashko MA; Yan D; Ding R; Guduru SKR; Zhou Y; Kania CE; Shelton Earp H
• UNC9426, a Potent and Orally Bioavailable TYRO3-Specific Inhibitor.
  J Med Chem Volume: 68 Page(s): 6665 - 6682
  03/27/2025 Authors: Kong D; Yang X; Judd S; Yan D; Springborn S; Stashko MA; Kidwell A; Huelse JM; Kireev D; Graham DK
• Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors.
  J Med Chem Volume: 67 Page(s): 5866 - 5882
  04/11/2024 Authors: Kong D; Tian Q; Chen Z; Zheng H; Stashko MA; Yan D; Earp HS; Frye SV; DeRyckere D; Kireev D
• Corrigendum to "Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J" [DNA Repair9 (2010) 1170-1175].
  DNA Repair (Amst) Volume: 134 Page(s): 103631
  02/01/2024 Authors: Ng WL; Yan D; Zhang X; Mo Y-Y; Wang Y
• Hope and Challenges: Immunotherapy in EGFR-Mutant NSCLC Patients.
  Biomedicines Volume: 11
  10/28/2023 Authors: Yan D
• Targeting a positive feedback loop of MERTK and STAT3 during macrophage differentiation may provide anti-tumor immune function
  Volume: 83
  04/01/2023 Authors: Yan D; Huelse JM; Bhasin SS; Bhasin M; DeRyckere D; Graham DK
• MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer.
  J Clin Invest Volume: 132
  08/01/2022 Authors: Yan D; Huelse JM; Kireev D; Tan Z; Chen L; Goyal S; Wang X; Frye SV; Behera M; Schneider F
• Targeting MERTK and AXL in EGFR Mutant Non-Small Cell Lung Cancer.
  Cancers (Basel) Volume: 13
  11/11/2021 Authors: Yan D; Earp HS; DeRyckere D; Graham DK
• MERTK drives residual tumor growth in EGFR-mutated non-small cell lung cancer cells treated with osimertinib
  Volume: 80
  08/01/2020 Authors: Yan D; Huelse J; Parker R; Tan Z; Wang X; Frye S; Earp HS; DeRyckere D; Graham DK
• MERTK is a potential therapeutic target in osimertinib-resistant non-small cell lung cancer
  Volume: 79
  07/01/2019 Authors: Yan D; Huelse J; Parker R; Wang X; Frye SV; Earp HS; DeRyckere D; Graham D
• MERTK Promotes Resistance to Irreversible EGFR Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancers Expressing Wild-type EGFR Family Members.
  Clin Cancer Res Volume: 24 Page(s): 6523 - 6535
  12/15/2018 Authors: Yan D; Parker RE; Wang X; Frye SV; Earp HS; DeRyckere D; Graham DK
• MerTK promotes resistance to irreversible EGFR TKIs by activation of the PI3K-AKT pathway in NSCLCs expressing wild-type EGFR
  Volume: 77
  07/01/2017 Authors: Yan D; Wang X; Frye SV; Earp SH; DeRyckere D; Graham DK
• Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex.
  J Med Chem Volume: 60 Page(s): 2305 - 2325
  03/23/2017 Authors: Jimnez-Somarribas A; Mao S; Yoon J-J; Weisshaar M; Cox RM; Marengo JR; Mitchell DG; Morehouse ZP; Yan D; Solis I
• Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening.
  J Virol Volume: 90 Page(s): 7368 - 7387
  08/15/2016 Authors: Weisshaar M; Cox R; Morehouse Z; Kyasa SK; Yan D; Oberacker P; Mao S; Golden JE; Lowen AC; Natchus MG
• Replication-Competent Influenza Virus and Respiratory Syncytial Virus Luciferase Reporter Strains Engineered for Co-Infections Identify Antiviral Compounds in Combination Screens.
  Biochemistry Volume: 54 Page(s): 5589 - 5604
  09/15/2015 Authors: Yan D; Weisshaar M; Lamb K; Chung HK; Lin MZ; Plemper RK
• Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity.
  J Med Chem Volume: 57 Page(s): 10314 - 10328
  12/26/2014 Authors: Matharu DS; Flaherty DP; Simpson DS; Schroeder CE; Chung D; Yan D; Noah JW; Jonsson CB; White EL; Aub J
• Cross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors.
  Proc Natl Acad Sci U S A Volume: 111 Page(s): E3441 - E3449
  08/19/2014 Authors: Yan D; Lee S; Thakkar VD; Luo M; Moore ML; Plemper RK
• An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.
  Sci Transl Med Volume: 6 Page(s): 232ra52
  04/16/2014 Authors: Krumm SA; Yan D; Hovingh ES; Evers TJ; Enkirch T; Reddy GP; Sun A; Saindane MT; Arrendale RF; Painter G
• Dual myxovirus screen identifies a small-molecule agonist of the host antiviral response.
  J Virol Volume: 87 Page(s): 11076 - 11087
  10/01/2013 Authors: Yan D; Krumm SA; Sun A; Steinhauer DA; Luo M; Moore ML; Plemper RK
• Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy.
  ACS Med Chem Lett Volume: 4 Page(s): 762 - 767
  08/08/2013 Authors: Moore TW; Sana K; Yan D; Krumm SA; Thepchatri P; Snyder JP; Marengo J; Arrendale RF; Prussia AJ; Natchus MG
• Asymmetric synthesis of host-directed inhibitors of myxoviruses.
  Beilstein J Org Chem Volume: 9 Page(s): 197 - 203
  01/01/2013 Authors: Moore TW; Sana K; Yan D; Thepchatri P; Ndungu JM; Saindane MT; Lockwood MA; Natchus MG; Liotta DC; Plemper RK
• A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis.
  Virology Volume: 434 Page(s): 129 - 136
  12/05/2012 Authors: Hotard AL; Shaikh FY; Lee S; Yan D; Teng MN; Plemper RK; Crowe JE; Moore ML
• Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics.
  J Med Chem Volume: 55 Page(s): 4220 - 4230
  05/10/2012 Authors: Ndungu JM; Krumm SA; Yan D; Arrendale RF; Reddy GP; Evers T; Howard R; Natchus MG; Saindane MT; Liotta DC
• Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires beta-catenin activation via Akt/GSK3-dependent and MTA1/Wnt1-dependent pathways
  CANCER RESEARCH Volume: 72
  04/15/2012 Authors: Yan D; Avtanski DB; Saxena NK; Sharma D
• Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires -catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways.
  J Biol Chem Volume: 287 Page(s): 8598 - 8612
  03/09/2012 Authors: Yan D; Avtanski D; Saxena NK; Sharma D
• The involvement of -actin in the signaling of transmembrane TNF--mediated cytotoxicity.
  J Leukoc Biol Volume: 89 Page(s): 917 - 926
  06/01/2011 Authors: Chen H; Xiao L; Zhang H; Liu N; Liu T; Liu L; Hu X; Yan D; Yang K; Yin B
• Identifying the key domain of CHK1 interaction with MEPE/OF45 and the key ubiquitination site of CHK1
  CANCER RESEARCH Volume: 71
  04/15/2011 Authors: Chen G; Yan D; Wang Y
• Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J.
  DNA Repair (Amst) Volume: 9 Page(s): 1170 - 1175
  11/10/2010 Authors: Ng WL; Yan D; Zhang X; Mo Y-Y; Wang Y
• Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation.
  PLoS One Volume: 5 Page(s): e11397
  07/01/2010 Authors: Yan D; Ng WL; Zhang X; Wang P; Zhang Z; Mo Y-Y; Mao H; Hao C; Olson JJ; Curran WJ
• Expression of TNF-alpha leader sequence renders MCF-7 tumor cells resistant to the cytotoxicity of soluble TNF-alpha.
  Breast Cancer Res Treat Volume: 116 Page(s): 91 - 102
  07/01/2009 Authors: Yan D; Qin N; Zhang H; Liu T; Yu M; Jiang X; Feng W; Wang J; Yin B; Zhang T
• Lipid rafts uncouple surface expression of transmembrane TNF-alpha from its cytotoxicity associated with ICAM-1 clustering in Raji cells.
  Mol Immunol Volume: 46 Page(s): 1551 - 1560
  04/01/2009 Authors: Zhang S; Liu T; Liang H; Zhang H; Yan D; Wang N; Jiang X; Feng W; Wang J; Li P
• Influence of reverse signaling via membrane TNF-alpha on cytotoxicity of NK92 cells.
  Eur J Cell Biol Volume: 88 Page(s): 181 - 191
  03/01/2009 Authors: Yu M; Shi W; Zhang J; Niu L; Chen Q; Yan D; Liu T; Jing W; Jiang X; Wei F
• Transmembrane TNF-alpha mediates "forward" and "reverse" signaling, inducing cell death or survival via the NF-kappaB pathway in Raji Burkitt lymphoma cells.
  J Leukoc Biol Volume: 84 Page(s): 789 - 797
  09/01/2008 Authors: Zhang H; Yan D; Shi X; Liang H; Pang Y; Qin N; Chen H; Wang J; Yin B; Jiang X
• The opposite effects on Raji cells associated with transmembrane TNF - alpha-mediated bidirectional signaling
  Volume: 21 Page(s): A443 - A443
  04/01/2007 Authors: Zhang H; Yan D; Shi X; Wang J; Jiang X; Li Z