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Profile

Dmitry Shayakhmetov PhD

  • Department of Pediatrics
    Professor
  • (404) 727-4038
  • dmitryshay@emory.edu
Head shot of Dmitry Shayakhmetov

Overview

Dr. Shayakhmetov obtained his BS degree in biochemistry and PhD degree in molecular biology and virology under the supervision of one of the leading virologists in Russia, Professor Thomas Tikchonenko. He obtained his postdoctoral training in virology and immunology in the laboratory of Dr. Andre Lieber, in the Department of Medicine at the University of Washington, in Seattle, where he was appointed to faculty as an Assistant Professor (2005) and later promoted to an Associate Professor (2010). Dr. Shayakhmetov joined the Lowance Center for Human Immunology at Emory University in April of 2014.

The main focus of Dr. Shayakhmetovs research program has been on improving our understanding of the role of innate immunity in initiating and exacerbating inflammation in response to viral (adenovirus) and bacterial pathogens, and tissue damage. The interplay between pro-inflammatory IL-1- and TNF-dependent signaling pathways in the context of infection and sterile tissue damage is the current focus of his research. Specifically, he is interested to understand the role of non-apoptotic pro-inflammatory cell death in triggering devastating local and systemic inflammation, associated with severe acute bacterial infections, sepsis, and several autoimmune and autoinflammatory disorders.

In 2008, Dr. Shayakhmetov was awarded the Outstanding New Investigator Award by the American Society of Gene and Cell Therapy for his contribution to deciphering molecular mechanisms triggering severe inflammation to adenovirus vectors in clinically-relevant settings.

Dr. Shayakhmetov is a member of several professional societies, including American Association of Immunologists, American Society for Microbiology, American Association for the Advancement of Science, and American Society of Gene and Cell Therapy. He serves as an Editorial Board member of Molecular Therapy, Cancer Gene Therapy, and Genes and Immunity journals, as well as participating as an ad hoc reviewer at the NIH study sections (VIR-A, GDD, and III) and many international grant review panels. Dr. Shayakhmetov has served as a regular member (2012-2014) and as a Chair (2014-2016) of the NIH Innate Immunity and Inflammation study section.

Over the years, Dr. Shayakhmetovs research program has been supported by the grants from the National Institutes of Health and private foundations, including Cystic Fibrosis Foundation and the Bill and Melinda Gates Foundation.

Academic Appointment

  • Professor of Pediatrics, Pediatrics - Rheumatology, Emory University School of Medicine
  • Professor of Medicine, Medicine - Rheumatology, Emory University School of Medicine

Education

Degrees

  • PHD from National Scientific Research Institute of Applied Biotechnology

Research

Publications

  • Improving efficacy of invivo therapy of sickle cell disease by hijacking natural biology of hematopoietic stem cells.
    Mol Ther Volume: 32 Page(s): 4167 - 4169
    12/04/2024 Authors: Yao J; Shayakhmetov DM
  • Targeted, safe, and efficient gene delivery to human hematopoietic stem and progenitor cells invivo using the engineered AVID adenovirus vector platform.
    Mol Ther Volume: 32 Page(s): 3743 - 3745
    10/02/2024 Authors: Yao J; Atasheva S; Wagner N; Di Paolo NC; Stewart PL; Shayakhmetov DM
  • TLR9-independent CD8+ Tcell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling.
    Mol Ther Volume: 32 Page(s): 325 - 339
    02/07/2024 Authors: Kumar SRP; Biswas M; Cao D; Arisa S; Muoz-Melero M; Lam AK; Pieros AR; Kapur R; Kaisho T; Kaufman RJ
  • Targeted, safe, and efficient gene delivery to human hematopoietic stem and progenitor cells in vivo using the engineered AVID adenovirus vector platform.
    Mol Ther Volume: 32 Page(s): 103 - 123
    01/03/2024 Authors: Yao J; Atasheva S; Wagner N; Di Paolo NC; Stewart PL; Shayakhmetov DM
  • A paracrine circuit of IL-1/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.
    J Clin Invest Volume: 133
    11/15/2023 Authors: Chen Z; Giotti B; Kaluzova M; Vallcorba MP; Rawat K; Price G; Herting CJ; Pinero G; Cristea S; Ross JL
  • Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus.
    Viruses Volume: 15
    06/09/2023 Authors: Wagner N; Shayakhmetov DM; Stewart PL
  • p38MAPK guards the integrity of endosomal compartments through regulating necrotic death.
    Sci Rep Volume: 12 Page(s): 16357
    09/29/2022 Authors: Yao J; Atasheva S; Toy R; Blanchard EL; Santangelo PJ; Roy K; Mocarski ES; Shayakhmetov DM
  • Adenovirus-based vaccines-a platform for pandemic preparedness against emerging viral pathogens.
    Mol Ther Volume: 30 Page(s): 1822 - 1849
    05/04/2022 Authors: Coughlan L; Kremer EJ; Shayakhmetov DM
  • Cytokine Responses to Adenovirus and Adenovirus Vectors.
    Viruses Volume: 14
    04/24/2022 Authors: Atasheva S; Shayakhmetov DM
  • Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation.
    Apoptosis Volume: 26 Page(s): 361 - 370
    06/01/2021 Authors: Kolachala VL; Lopez C; Shen M; Shayakhmetov D; Gupta NA
  • Oncolytic Viruses for Systemic Administration: Engineering a Whole Different Animal.
    Mol Ther Volume: 29 Page(s): 904 - 907
    03/03/2021 Authors: Atasheva S; Shayakhmetov DM
  • Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells.
    PLoS Pathog Volume: 17 Page(s): e1009168
    01/01/2021 Authors: Lee W; Kingstad-Bakke B; Paulson B; Larsen A; Overmyer K; Marinaik CB; Dulli K; Toy R; Vogel G; Mueller KP
  • TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation.
    Sci Adv Volume: 7
    01/01/2021 Authors: Pradhan P; Toy R; Jhita N; Atalis A; Pandey B; Beach A; Blanchard EL; Moore SG; Gaul DA; Santangelo PJ
  • Systemic cancer therapy with engineered adenovirus that evades innate immunity.
    Sci Transl Med Volume: 12
    11/25/2020 Authors: Atasheva S; Emerson CC; Yao J; Young C; Stewart PL; Shayakhmetov DM
  • Cellular dynamics of productive anti-tumor response mediating long-term rejection of disseminated lung tumors after systemic therapy with oncolytic adenovirus
    Volume: 80
    08/01/2020 Authors: Yao J; Atasheva S; Young CB; Shayakhmetov DM
  • Tumor-targeted oncolytic adenovirus demonstrates high cytotoxicity for human lung and renal cell carcinomas independently of the level of tumor PD-L1 expression.
    Volume: 38
    05/20/2020 Authors: Yao J; Atasheva S; Young C; Master VA; Shayakhmetov D
  • IRF5 Drives Potentiated IFN-beta and IL-12 production by dendritic cells in response to combinatorial CpG- and MPLA- delivery on microparticles
    Volume: 204
    05/01/2020 Authors: Jhita N; Toy R; Pradhan P; Blanchard E; Narang N; Cortes G; Keenum MC; Santangelo PJ; Shayakhmetov DM; Roy K
  • Cellular Innate Immune Mechanisms Mediating Long-Term Rejection of Disseminated Lung Tumors after Systemic Therapy with Oncolytic Adenovirus
    Volume: 28 Page(s): 156 - 156
    04/28/2020 Authors: Yao J; Atasheva S; Young C; Shayakhmetov D
  • Single-Cell Transcriptomics Analysis of a Complete Response Phenotype in Mice with Disseminated Lung Cancer after Systemic Therapy with Oncolytic Adenovirus
    Volume: 28 Page(s): 591 - 591
    04/28/2020 Authors: Atasheva S; Yao J; Young C; Shayakhmetov D
  • Innate immunity to adenovirus: lessons from mice.
    FEBS Lett Volume: 593 Page(s): 3461 - 3483
    12/01/2019 Authors: Atasheva S; Yao J; Shayakhmetov DM
  • Tumour-associated macrophage-derived interleukin-1 mediates glioblastoma-associated cerebral oedema.
    Brain Volume: 142 Page(s): 3834 - 3851
    12/01/2019 Authors: Herting CJ; Chen Z; Maximov V; Duffy A; Szulzewsky F; Shayakhmetov DM; Hambardzumyan D
  • Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways.
    Biomaterials Volume: 225 Page(s): 119512
    12/01/2019 Authors: Toy R; Pradhan P; Ramesh V; Di Paolo NC; Lash B; Liu J; Blanchard EL; Pinelli CJ; Santangelo PJ; Shayakhmetov DM
  • Preclinical assessment of efficacy and safety of novel oncolytic adenovirus for therapy of disseminated lung cancer
    Volume: 79
    07/01/2019 Authors: Atasheva S; Yao J; Young C; Di Paolo NC; Wyche H; Shayakhmetov DM
  • Influence of Fat on Differential Receptor Interacting Serine/Threonine Protein Kinase 1 Activity Leading to Apoptotic Cell Death in Murine Liver Ischemia Reperfusion Injury Through Caspase 8.
    Hepatol Commun Volume: 3 Page(s): 925 - 942
    07/01/2019 Authors: Kolachala VL; Palle SK; Shen M; Shenoi A; Shayakhmetov DM; Gupta NA
  • Development of an Oncolytic Adenovirus for Systemic Intravascular Administration for Treatment of Solid and Disseminated Tumors in Mouse Lung Adenocarcinoma Model
    Volume: 27 Page(s): 123 - 124
    04/22/2019 Authors: Atasheva S; Emerson C; Young C; Stewart P; Shayakhmetov D
  • Pre-Clinical Assessment of Efficacy and Safety of Novel Oncolytic Adenovirus for Therapy of Disseminated Lung Cancer
    Volume: 27 Page(s): 121 - 122
    04/22/2019 Authors: Atasheva S; Yao J; Young C; Di Paolo N; Wyche H; Shayakhmetov D
  • INTERLEUKIN 1 SIGNALING REGULATES BLOOD-BRAIN BARRIER INTEGRITY IN GLIOBLASTOMA
    Volume: 20 Page(s): 31 - 32
    11/01/2018 Authors: Herting C; Shayakhmetov D; Hambardzumyan D
  • Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
    Immunity Volume: 49 Page(s): 42 - 55.e6
    07/17/2018 Authors: Mandal P; Feng Y; Lyons JD; Berger SB; Otani S; DeLaney A; Tharp GK; Maner-Smith K; Burd EM; Schaeffer M
  • Inflammasome components caspase-1 and adaptor protein apoptosis-associated speck-like proteins are important in resistance to Cryptosporidium parvum.
    Microbes Infect Volume: 20 Page(s): 369 - 375
    01/01/2018 Authors: McNair NN; Bedi C; Shayakhmetov DM; Arrowood MJ; Mead JR
  • DELINEATING THE THERAPEUTIC MECHANISM OF DEXAMETHASONE IN GLIOBLASTOMA-RELATED CEREBRAL EDEMA
    Volume: 19 Page(s): 254 - 254
    11/01/2017 Authors: Herting C; Shayakhmetov D; Hambardzumyan D
  • Loss of L-selectin-guided CD8+ , but not CD4+ , cells protects against ischemia reperfusion injury in a steatotic liver.
    Hepatology Volume: 66 Page(s): 1258 - 1274
    10/01/2017 Authors: Kolachala VL; Palle S; Shen M; Feng A; Shayakhmetov D; Gupta NA
  • Molecular Determinants Limiting Productive Replication of Human Adenovirus in Mouse Cells
    Volume: 25 Page(s): 266 - 266
    05/01/2017 Authors: Atasheva S; Shayakhmetov D
  • Adenovirus sensing by the immune system.
    Curr Opin Virol Volume: 21 Page(s): 109 - 113
    12/01/2016 Authors: Atasheva S; Shayakhmetov DM
  • Hepatocellular injury is mediated through Caspase 1/11 and IL-1 receptor in steatotic liver undergoing ischemia reperfusion injury
    Volume: 64 Page(s): 89A - 89A
    10/01/2016 Authors: Kolachala VL; Palle SK; Shen M; Shayakhmetov D; Gupta NA
  • Interleukin 1 and the inflammatory process.
    Nat Immunol Volume: 17 Page(s): 906 - 913
    07/19/2016 Authors: Di Paolo NC; Shayakhmetov DM
  • Functional Role of Adenovirus Penton in Modulating In Vivo Properties of Liver-Targeted and Liver-Detargeted Adenovirus Variants
    Volume: 24 Page(s): S7 - S7
    05/01/2016 Authors: Atasheva S; Emerson C; Di Paolo NC; Irons E; Gulati N; Stewart P; Shayakhmetov DM
  • Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo.
    J Virol Volume: 90 Page(s): 412 - 420
    01/01/2016 Authors: Zaiss AK; Foley EM; Lawrence R; Schneider LS; Hoveida H; Secrest P; Catapang AB; Yamaguchi Y; Alemany R; Shayakhmetov DM
  • Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo.
    PLoS One Volume: 11 Page(s): e0151252
    01/01/2016 Authors: Ciraci C; Janczy JR; Jain N; Haasken S; Pecli E Silva C; Benjamim CF; Sadler JJ; Olivier AK; Iwakura Y; Shayakhmetov DM
  • Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis Infection.
    Immunity Volume: 43 Page(s): 1125 - 1136
    12/15/2015 Authors: Di Paolo NC; Shafiani S; Day T; Papayannopoulou T; Russell DW; Iwakura Y; Sherman D; Urdahl K; Shayakhmetov DM
  • Blockade of RIP kinase pathway exacerbates ischemia reperfusion injury in a steatotic liver
    Volume: 62 Page(s): 213A - 213A
    10/01/2015 Authors: Palle S; Kolachala VL; Shen M; Abramowsky CR; Shayakhmetov D; Gupta NA
  • Adenovirus Variant With a Defined Set of Genetic Mutations in the Penton and Hexon Escapes Liver Sequestration After Intravascular Administration
    Volume: 23 Page(s): S20 - S20
    05/01/2015 Authors: Atasheva S; Di Paolo N; Doronin K; Shayakhmetov D
  • Mycobacterium tuberculosis strains lacking surface lipid phthiocerol dimycocerosate are susceptible to killing by an early innate host response.
    Infect Immun Volume: 82 Page(s): 5214 - 5222
    12/01/2014 Authors: Day TA; Mittler JE; Nixon MR; Thompson C; Miner MD; Hickey MJ; Liao RP; Pang JM; Shayakhmetov DM; Sherman DR
  • Retinal transduction profiles by high-capacity viral vectors.
    Gene Ther Volume: 21 Page(s): 855 - 865
    10/01/2014 Authors: Puppo A; Cesi G; Marrocco E; Piccolo P; Jacca S; Shayakhmetov DM; Parks RJ; Davidson BL; Colloca S; Brunetti-Pierri N
  • Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): 7391 - 7396
    05/20/2014 Authors: Weng D; Marty-Roix R; Ganesan S; Proulx MK; Vladimer GI; Kaiser WJ; Mocarski ES; Pouliot K; Chan FK-M; Kelliher MA
  • IL-1alpha-IL-1RI-CXCR2 Axis and Complement Cooperate in Triggering Local Neutrophilic Inflammation and Elimination of Virus-Containing Cells in Response to Adenovirus
    Volume: 22 Page(s): S74 - S74
    05/01/2014 Authors: Di Paolo NC; Baldwin LK; Papayannopoulou T; Tomlinson S; Shayakhmetov DM
  • Adenovirus Vectors With Large Substitutions in the Penton Base RGD Loop Retain Infectivity and Elicit a Diminished Innate Immune Response In Vivo
    Volume: 22 Page(s): S189 - S189
    05/01/2014 Authors: Irons E; Doronin K; Di Paolo N; Baldwin L; Shayakhmetov D
  • IL-1 and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells.
    PLoS Pathog Volume: 10 Page(s): e1004035
    03/01/2014 Authors: Di Paolo NC; Baldwin LK; Irons EE; Papayannopoulou T; Tomlinson S; Shayakhmetov DM
  • Inflammasome-independent IL-1 mediates autoinflammatory disease in Pstpip2-deficient mice.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): 1072 - 1077
    01/21/2014 Authors: Cassel SL; Janczy JR; Bing X; Wilson SP; Olivier AK; Otero JE; Iwakura Y; Shayakhmetov DM; Bassuk AG; Abu-Amer Y
  • The analysis of innate immune response to adenovirus using antibody arrays.
    Methods Mol Biol Volume: 1089 Page(s): 133 - 141
    01/01/2014 Authors: Di Paolo NC; Shayakhmetov DM
  • Coagulation factor binding orientation and dimerization may influence infectivity of adenovirus-coagulation factor complexes.
    J Virol Volume: 87 Page(s): 9610 - 9619
    09/01/2013 Authors: Irons EE; Flatt JW; Doronin K; Fox TL; Acchione M; Stewart PL; Shayakhmetov DM
  • The transcription factor IRF3 triggers "defensive suicide" necrosis in response to viral and bacterial pathogens.
    Cell Rep Volume: 3 Page(s): 1840 - 1846
    06/27/2013 Authors: Di Paolo NC; Doronin K; Baldwin LK; Papayannopoulou T; Shayakhmetov DM
  • Molecular Modeling of Coagulation FVII Binding to Adenovirus Hexon Revealed a Binding Pocket for Coagulation Factor GLA Domain That Defines the Infectivity of Adenovirus-Coagulation Factor Complexes
    Volume: 21 Page(s): S184 - S184
    06/01/2013 Authors: Irons EE; Flatt JW; Doronin K; Fox TL; Acchione M; Stewart PL; Shayakhmetov DM
  • FX and host defense evasion tactics by adenovirus.
    Mol Ther Volume: 21 Page(s): 1109 - 1111
    06/01/2013 Authors: Baker AH; Nicklin SA; Shayakhmetov DM
  • Monocyte-derived IL-1 alpha enables host resistance to M. tuberculosis by activating stroma-derived TNF-alpha and stalling pathogen replication in vivo. (P1247)
    Volume: 190
    05/01/2013 Authors: Shayakhmetov D; Di Paolo N; Shafiani S; Day T; Papayannopoulou T; Russell D; Iwakura Y; Sherman D; Urdahl K
  • Interleukin-1 receptor 2 keeps the lid on interleukin-1.
    Immunity Volume: 38 Page(s): 203 - 205
    02/21/2013 Authors: Di Paolo NC; Shayakhmetov DM
  • Coagulation factor X activates innate immunity to human species C adenovirus.
    Science Volume: 338 Page(s): 795 - 798
    11/09/2012 Authors: Doronin K; Flatt JW; Di Paolo NC; Khare R; Kalyuzhniy O; Acchione M; Sumida JP; Ohto U; Shimizu T; Akashi-Takamura S
  • Protease-Activated Receptor 2 Cooperates with Toll-Like Receptor 4 in Sensing of Adenovirus-Coagulation Factor X Complex and Activating Innate Immune and Inflammatory Responses
    Volume: 20 Page(s): S117 - S117
    05/01/2012 Authors: Di Paolo NC; Baldwin LK; Hollenberg MD; Shayakhmetov DM
  • A Dynamic Shift from Cytokine to Cell Death-Mediated Stimuli Orchestrates Macrophage-Driven Local Neutrophilic Inflammation in Response to Adenovirus In Vivo
    Volume: 20 Page(s): S276 - S276
    05/01/2012 Authors: Di Paolo NC; Baldwin LK; Papayannopoulou T; Shayakhmetov DM
  • Construction of targeted and armed oncolytic adenoviruses.
    Methods Mol Biol Volume: 797 Page(s): 35 - 52
    01/01/2012 Authors: Doronin K; Shayakhmetov DM
  • Recognition of virus infection and innate host responses to viral gene therapy vectors.
    Mol Ther Volume: 18 Page(s): 1422 - 1429
    08/01/2010 Authors: Shayakhmetov DM; Di Paolo NC; Mossman KL
  • Virus infection recognition and early innate responses to non-enveloped viral vectors.
    Viruses Volume: 2 Page(s): 244 - 261
    01/01/2010 Authors: Shayakhmetov DM
  • Adenovirus de-targeting from the liver.
    Curr Opin Mol Ther Volume: 11 Page(s): 523 - 531
    10/01/2009 Authors: Di Paolo NC; Shayakhmetov DM
  • Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.
    Immunity Volume: 31 Page(s): 110 - 121
    07/17/2009 Authors: Di Paolo NC; Miao EA; Iwakura Y; Murali-Krishna K; Aderem A; Flavell RA; Papayannopoulou T; Shayakhmetov DM
  • Transduction of liver metastases after intravenous injection of Ad5/35 or Ad35 vectors with and without factor X-binding protein pretreatment.
    Hum Gene Ther Volume: 20 Page(s): 621 - 629
    06/01/2009 Authors: Liu Y; Wang H; Yumul R; Gao W; Gambotto A; Morita T; Baker A; Shayakhmetov D; Lieber A
  • The Interaction of Adenovirus with the beta-3 Integrin Mediates the Activation of IL-1alpha, a Key Cytokine That Triggers the Immediate Pro-Response In Vivo
    Volume: 17 Page(s): S167 - S167
    05/01/2009 Authors: Di Paolo NC; Miao EA; Iwakura Y; Aderem A; Flavell R; Papayannopoulou T; Shayakhmetov DM
  • Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver.
    Mol Ther Volume: 17 Page(s): 675 - 684
    04/01/2009 Authors: Di Paolo NC; van Rooijen N; Shayakhmetov DM
  • In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46.
    J Virol Volume: 82 Page(s): 10567 - 10579
    11/01/2008 Authors: Wang H; Liu Y; Li Z; Tuve S; Stone D; Kalyushniy O; Shayakhmetov D; Verlinde CLM; Stehle T; McVey J
  • Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo.
    Proc Natl Acad Sci U S A Volume: 105 Page(s): 5483 - 5488
    04/08/2008 Authors: Kalyuzhniy O; Di Paolo NC; Silvestry M; Hofherr SE; Barry MA; Stewart PL; Shayakhmetov DM
  • Identification of CD46 binding sites within the adenovirus serotype 35 fiber knob.
    J Virol Volume: 81 Page(s): 12785 - 12792
    12/01/2007 Authors: Wang H; Liaw Y-C; Stone D; Kalyuzhniy O; Amiraslanov I; Tuve S; Verlinde CLMJ; Shayakhmetov D; Stehle T; Roffler S
  • Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells.
    Nature Volume: 450 Page(s): 110 - 114
    11/01/2007 Authors: Junt T; Moseman EA; Iannacone M; Massberg S; Lang PA; Boes M; Fink K; Henrickson SE; Shayakhmetov DM; Di Paolo NC
  • Fiber shaft-chimeric adenovirus vectors lacking the KKTK motif efficiently infect liver cells in vivo.
    J Virol Volume: 81 Page(s): 12249 - 12259
    11/01/2007 Authors: Di Paolo NC; Kalyuzhniy O; Shayakhmetov DM
  • The influence of blood on in vivo adenovirus bio-distribution and transduction.
    Mol Ther Volume: 15 Page(s): 1410 - 1416
    08/01/2007 Authors: Baker AH; Mcvey JH; Waddington SN; Di Paolo NC; Shayakhmetov DM
  • Adenovirus-platelet interaction in blood causes virus sequestration to the reticuloendothelial system of the liver.
    J Virol Volume: 81 Page(s): 4866 - 4871
    05/01/2007 Authors: Stone D; Liu Y; Shayakhmetov D; Li Z-Y; Ni S; Lieber A
  • Identifying functional adenovirus-host interactions using tandem mass spectrometry.
    Methods Mol Med Volume: 131 Page(s): 141 - 155
    01/01/2007 Authors: Gaggar A; Shayakhmetov D; Lieber A
  • A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells.
    J Virol Volume: 80 Page(s): 12109 - 12120
    12/01/2006 Authors: Tuve S; Wang H; Ware C; Liu Y; Gaggar A; Bernt K; Shayakhmetov D; Li Z; Strauss R; Stone D
  • Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes.
    Blood Volume: 108 Page(s): 2554 - 2561
    10/15/2006 Authors: Parker AL; Waddington SN; Nicol CG; Shayakhmetov DM; Buckley SM; Denby L; Kemball-Cook G; Ni S; Lieber A; McVey JH
  • Hepatic Tropism of Adenoviral Type 5 Vectors Can Be Mediated by Multiple Coagulation Factors
    MOLECULAR THERAPY Volume: 13 Page(s): S143 - S143
    05/01/2006 Authors: Parker AL; Nicol CG; Waddington SN; Buckley SM; Shayakhmetov DM; Ni SH; Lieber A; McVey JH; Denby L; Nicklin SA
  • Identification of Structural Aspects of Adenovirus Interactions with Host Factors In Vivo Using Tandem Mass Spectrometry
    MOLECULAR THERAPY Volume: 13 Page(s): S144 - S144
    05/01/2006 Authors: Kalyuzhniy O; Doneanu C; Sadilek M; Shayakhmetov DM
  • Intravascular Delivery of Adenovirus Vectors Rapidly Targets Platelets to the Reticuloendothelial System
    MOLECULAR THERAPY Volume: 13 Page(s): S143 - S144
    05/01/2006 Authors: Stone D; Ni S; Li Z-Y; Shayakhmetov D; Lieber A
  • Intravascular Interaction between Adenovirus and Platelets Promotes Adenovirus Sequestration, Degradation and Toxicity
    MOLECULAR THERAPY Volume: 13 Page(s): S30 - S31
    05/01/2006 Authors: Stone D; Ni S; Li Z-Y; Shayakhmetov D; Lieber A
  • Enrichment and Characterization of Ovarian Cancer Stem Cells
    MOLECULAR THERAPY Volume: 13 Page(s): S40 - S41
    05/01/2006 Authors: Li ZY; Strauss R; Sova P; Ni S; Yu M; Shayakhmetov D; Drescher C; Urban N; Lieber A
  • Evaluation of adenovirus vectors containing serotype 35 fibers for vaccination.
    Mol Ther Volume: 13 Page(s): 756 - 765
    04/01/2006 Authors: DiPaolo N; Ni S; Gaggar A; Strauss R; Tuve S; Li ZY; Stone D; Shayakhmetov D; Kiviat N; Tour P
  • A capsid-modified helper-dependent adenovirus vector containing the beta-globin locus control region displays a nonrandom integration pattern and allows stable, erythroid-specific gene expression.
    J Virol Volume: 79 Page(s): 10999 - 11013
    09/01/2005 Authors: Wang H; Shayakhmetov DM; Leege T; Harkey M; Li Q; Papayannopoulou T; Stamatoyannopolous G; Lieber A
  • Interference with the IL-1-signaling pathway improves the toxicity profile of systemically applied adenovirus vectors.
    J Immunol Volume: 174 Page(s): 7310 - 7319
    06/01/2005 Authors: Shayakhmetov DM; Li Z-Y; Ni S; Lieber A
  • Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity.
    J Virol Volume: 79 Page(s): 7478 - 7491
    06/01/2005 Authors: Shayakhmetov DM; Gaggar A; Ni S; Li Z-Y; Lieber A
  • Localization of regions in CD46 that interact with adenovirus.
    J Virol Volume: 79 Page(s): 7503 - 7513
    06/01/2005 Authors: Gaggar A; Shayakhmetov DM; Liszewski MK; Atkinson JP; Lieber A
  • Development of high-capacity gutless adenovirus vectors for gene transfer into human hematopoietic cells.
    Volume: 34 Page(s): 121 - 122
    03/01/2005 Authors: Shayakhmetov D; Wang HJ; Leege T; Lieber A
  • Deletion of penton RGD motifs affects the efficiency of both the internalization and the endosome escape of viral particles containing adenovirus serotype 5 or 35 fiber knobs.
    J Virol Volume: 79 Page(s): 1053 - 1061
    01/01/2005 Authors: Shayakhmetov DM; Eberly AM; Li Z-Y; Lieber A
  • Genome size and structure determine efficiency of postinternalization steps and gene transfer of capsid-modified adenovirus vectors in a cell-type-specific manner.
    J Virol Volume: 78 Page(s): 10009 - 10022
    09/01/2004 Authors: Shayakhmetov DM; Li Z-Y; Gaggar A; Gharwan H; Ternovoi V; Sandig V; Lieber A
  • Helper-dependent, capsid-modified adenoviral vectors for immunotherapy of breast cancer
    Volume: 9 Page(s): S104 - S104
    05/01/2004 Authors: Di Paolo NC; Stone D; Shayakhmetov D; Lieber A
  • Interference with the IL-1 signaling pathway significantly improves the toxicity profile of systemically applied adenovirus vectors
    Volume: 9 Page(s): S386 - S387
    05/01/2004 Authors: Shayakhmetov DM; Li ZY; Ni SH; Lieber A
  • Stable gene expression under the control of the beta-globin LCR in hematopoietic cells after transduction with integrating helper-dependent adeno-AAV vectors
    Volume: 9 Page(s): S343 - S343
    05/01/2004 Authors: Wang HJ; Shayakhmetov D; Li QL; Papayannopoulou T; Stamatoyannopolous G; Lieber A
  • Vector host interactions of group B Adenoviruses in CD46 transgenic mice
    Volume: 9 Page(s): S53 - S53
    05/01/2004 Authors: Gaggar A; Shayakhmetov DM; Marwah S; Ni SH; Lieber AM
  • Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors.
    J Virol Volume: 78 Page(s): 5368 - 5381
    05/01/2004 Authors: Shayakhmetov DM; Li Z-Y; Ni S; Lieber A
  • Identification of CD46 as a cellular receptor for group B adenoviruses.
    Volume: 52 Page(s): S150 - S151
    01/01/2004 Authors: Gaggar A; Shayakhmetov D; Lieber A
  • The effect of sequestration by nontarget tissues on anti-tumor efficacy of systemically applied, conditionally replicating adenovirus vectors (vol 8, pg 746, 2003)
    MOLECULAR THERAPY Volume: 9 Page(s): 139 - 139
    01/01/2004 Authors: Bernt KM; Ni SH; Gaggar A; Li ZY; Shayakhmetov DM; Lieber A
  • CD46 is a cellular receptor for group B adenoviruses.
    Nat Med Volume: 9 Page(s): 1408 - 1412
    11/01/2003 Authors: Gaggar A; Shayakhmetov DM; Lieber A
  • The effect of sequestration by nontarget tissues on anti-tumor efficacy of systemically applied, conditionally replicating adenovirus vectors.
    Mol Ther Volume: 8 Page(s): 746 - 755
    11/01/2003 Authors: Bernt KM; Ni S; Gaggar A; Li ZY; Shayakhmetov DM; Lieber A
  • Identification of a cellular receptor for group B2 adenoviruses
    Volume: 7 Page(s): S164 - S164
    05/01/2003 Authors: Gaggar A; Shayakhmetov DM; Lieber A
  • Binding of adenovirus fiber knob to blood coagulation factors mediates CAR-independent liver tropism
    Volume: 7 Page(s): S165 - S165
    05/01/2003 Authors: Shayakhmetov DM; Gaggar A; Ni SH; Krasnykh V; Lieber A
  • The infectivity pathway selected by adenovirus in vivo alters its acute toxicity after intravenous vector administration
    Volume: 7 Page(s): S56 - S57
    05/01/2003 Authors: Shayakhmetov DM; Eberly AL; Ni SH; Li ZY; Lieber A
  • The effect of sequestrastion by non-target tissues on the efficacy of adenoviral gene therapy vectors
    Volume: 7 Page(s): S172 - S173
    05/01/2003 Authors: Bernt KM; Ni SH; Shayakhmetov D; Lieber A; Li ZY
  • A chimeric helper-dependent gutless ad5/35 adenovirus vector for dual adeno-/retroviral transduction of hematopoietic stem/progenitor cells
    Volume: 7 Page(s): S197 - S197
    05/01/2003 Authors: Gharwan H; Shayakhmetov DM; Lieber AM; Stamatoyannopoulos G
  • New models for in vivo gene therapy targeted to human metastasis-associated vascular endothelium
    Volume: 7 Page(s): S432 - S432
    05/01/2003 Authors: Mealiffe ME; Gaggar A; Ni SH; Li ZY; Shayakhmetov DM; Lieber A
  • The role of the penton RGD motif in internalization and endosome escape of capsid-modified adenovirus vectors
    Volume: 7 Page(s): S48 - S49
    09/08/2003 Authors: Eberly AL; Shayakhmetov DM; Lieber A
  • The interaction between the fiber knob domain and the cellular attachment receptor determines the intracellular trafficking route of adenoviruses.
    J Virol Volume: 77 Page(s): 3712 - 3723
    03/01/2003 Authors: Shayakhmetov DM; Li Z-Y; Ternovoi V; Gaggar A; Gharwan H; Lieber A
  • Generation of adenovirus vectors devoid of all viral genes by recombination between inverted repeats.
    Methods Mol Med Volume: 76 Page(s): 135 - 152
    01/01/2003 Authors: Stecher H; Carlson CA; Shayakhmetov DM; Lieber A
  • Advances in gene transfer into haematopoietic stem cells by adenoviral vectors.
    Expert Opin Biol Ther Volume: 2 Page(s): 847 - 856
    12/01/2002 Authors: Marini FC; Shayakhmetov D; Gharwan H; Lieber A; Andreeff M
  • An adenoviral expression system for AAV rep78 using homologous recombination.
    Mol Ther Volume: 6 Page(s): 91 - 98
    07/01/2002 Authors: Carlson CA; Shayakhmetov DM; Lieber A
  • Restoration of a functional open reading frame by homologous recombination between two adenoviral vectors.
    Mol Ther Volume: 6 Page(s): 99 - 105
    07/01/2002 Authors: Carlson CA; Shayakhmetov DM; Lieber A
  • Targeting of human hematopoietic stem cells with adenovirus vectors.
    BLOOD CELLS MOLECULES AND DISEASES Volume: 28 Page(s): 344 - 345
    05/01/2002 Authors: Shayakhmetov DM; Gharwan H; Bernt K; Papayannopoulou T; Stamatoyannopoulos G; Lieber A
  • Capsid-modified Ad.AAV vectors for stable transduction of human hematopoietic cells.
    BLOOD CELLS MOLECULES AND DISEASES Volume: 28 Page(s): 334 - 335
    05/01/2002 Authors: Lieber A; Shayakhmetov DM; Li QL; Stamatoyannopoulos G
  • Targeting of adenovirus vectors to tumor cells does not enable efficient transduction of breast cancer metastases.
    Cancer Res Volume: 62 Page(s): 1063 - 1068
    02/15/2002 Authors: Shayakhmetov DM; Li Z-Y; Ni S; Lieber A
  • A high-capacity, capsid-modified hybrid adenovirus/adeno-associated virus vector for stable transduction of human hematopoietic cells.
    J Virol Volume: 76 Page(s): 1135 - 1143
    02/01/2002 Authors: Shayakhmetov DM; Carlson CA; Stecher H; Li Q; Stamatoyannopoulos G; Lieber A
  • Rearrangements in adenoviral genomes mediated by inverted repeats.
    Methods Enzymol Volume: 346 Page(s): 277 - 292
    01/01/2002 Authors: Carlson CA; Steinwaerder DS; Stecher H; Shayakhmetov DM; Lieber A
  • Recombinant adenovirus vectors for tumor-specific gene delivery and expression
    CANCER GENE THERAPY Volume: 8 Page(s): 687 - 688
    09/01/2001 Authors: Lieber A; Steinwaerder D; Mi J; Shayakhmetov D
  • A capsid-modified adenovirus vector devoid of all viral genes: assessment of transduction and toxicity in human hematopoietic cells.
    Mol Ther Volume: 4 Page(s): 36 - 44
    07/01/2001 Authors: Stecher H; Shayakhmetov DM; Stamatoyannopoulos G; Lieber A
  • Efficient infection of primitive hematopoietic stem cells by modified adenovirus.
    Gene Ther Volume: 8 Page(s): 930 - 937
    06/01/2001 Authors: Yotnda P; Onishi H; Heslop HE; Shayakhmetov D; Lieber A; Brenner M; Davis A
  • Gene transfer into human hematopoietic cells with chimeric adenovirus vectors, devoid of all viral genes.
    BLOOD Volume: 96 Page(s): 430A - 430A
    11/16/2000 Authors: Shayakhmetov DM; Farrer D; Papayannopoulou T; Stamatoyannopoulos G; Lieber A
  • Sequential transduction of human hematopoietic stem cells with retargeted adenovirus vectors devoid of all viral genes encoding the ecotropic retrovirus receptor followed by an ecotropic retrovirus vector.
    BLOOD Volume: 96 Page(s): 384B - 384B
    11/16/2000 Authors: Stecher H; Shayakhmetov D; Farrer D; Stamatoyannopoulos G; Lieber A
  • High efficiency gene transfer to normal and malignant hematopoietic precursor cells using a chimeric adenovirus.
    BLOOD Volume: 96 Page(s): 218A - 218A
    11/16/2000 Authors: Yotnda P; Onishi H; Heslop H; Brenner M; Shayakhmetov D; Lieber A; Davis A
  • Dependence of adenovirus infectivity on length of the fiber shaft domain.
    J Virol Volume: 74 Page(s): 10274 - 10286
    11/01/2000 Authors: Shayakhmetov DM; Lieber A
  • Sequential transduction of human hematopoietic stem cells with retargeted adenovirus vectors devoid of all viral genes encoding the ecotropic retrovirus receptor followed by an ecotropic retrovirus vector.
    BLOOD CELLS MOLECULES AND DISEASES Volume: 26 Page(s): 528 - 529
    10/01/2000 Authors: Stecher H; Shayakhmetov D; Stamatoyannopoulos G; Lieber A
  • Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector.
    J Virol Volume: 74 Page(s): 2567 - 2583
    03/01/2000 Authors: Shayakhmetov DM; Papayannopoulou T; Stamatoyannopoulos G; Lieber A
  • [Antisense RNA, suppressing the reproduction of bovine leukemia virus in cell culture, binds effectively with an RNA target in vitro].
    Mol Biol (Mosk) Volume: 32 Page(s): 332 - 340
    01/01/1998 Authors: Shaiakhmetov DM; Ternovo VV; Borisenko AS; Tikhonenko TI
  • Use of the bovine leukaemia virus LTR U3 promoter for expressing antisense antiviral RNAs and competitive inhibition of viral infection in cell culture.
    J Gen Virol Volume: 78 ( Pt 8) Page(s): 1941 - 1948
    08/01/1997 Authors: Shayakhmetov D; Kovalenko D; Yurov G; Borisenko A; Tikchonenko T
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