David Goldsmith

Department of Psychiatry and Behavioral Sciences
Associate Professor

Overview

Dr. David R. Goldsmith is an Associate Professor in the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine and is the Associate Program Director for the Psychiatry Residency Research Track. He is also on Faculty in the Emory Behavioral Immunology Program. Dr. Goldsmiths research program investigates the impact of inflammatory markers on brain reward circuitry, motivational deficits, and negative symptoms in patients with schizophrenia. He is currently funded by an R01 from the National Institute of Mental Health to use the TNF-antagonist infliximab in an experimental medicine study testing its effects on brain circuitry and behavior, which builds on data collected during his K23 Career Development Award. Clinically, Dr. Goldsmith co-directs the Clinical and Research Program for Psychosis at Grady and is the Director of the PSTAR (Persistent Symptoms: Treatment, Assessment, and Recovery) Clinic where he treats patients with persistent symptoms of psychosis. Dr. Goldsmith serves as an Associate Editor of Schizophrenia Research and is on the Editorial Board of Brain, Behavior, and Immunity. He is also an Associate Member of the American College of Neuropsychopharmacology. He has been recognized a number of times for his research and teaching including two Deans Teaching Awards from the Emory University School of Medicine in addition to awards from the Schizophrenia International Research Society and the Society of Biological Psychiatry.

Academic Appointment

Assistant Professor, Psychiatry and Behavioral Sciences, Emory University
Associate Program Director, Research Track, Psychiatry and Behavioral Sciences, Emory University

Education

Degrees

Pre-medical Post-baccalaureate Certificate from Johns Hopkins University
BS from University of Maryland, College Park
MSc from Emory University
MD from Emory University

Research

Publications

Inflammation is associated with avolition and reduced resting state functional connectivity in corticostriatal reward circuitry in patients with schizophrenia.
Neuropsychopharmacology
04/24/2025 Authors: Goldsmith DR; Ning CS; Strauss GP; Gross RE; Cooper JA; Wommack EC; Haroon E; Felger JC; Walker EF; Treadway MT
Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part II: A Review of Fatal Outcomes in US Pharmacovigilance Data and Proposed Changes.
J Clin Psychopharmacol
04/09/2025 Authors: de Leon J; Baldessarini RJ; Balon R; Bilbily J; Caroff SN; Citrome L; Correll CU; Cotes RO; Davis JM; DeLisi LE
Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part I: A Review of the Pharmacokinetic Literature and Proposed Changes.
J Clin Psychopharmacol
04/09/2025 Authors: de Leon J; Baldessarini RJ; Balon R; Bilbily J; Caroff SN; Citrome L; Correll CU; Cotes RO; Davis JM; DeLisi LE
Sustained effects of repeated levodopa (L-DOPA) administration on reward circuitry, effort-based motivation, and anhedonia in depressed patients with higher inflammation.
Brain Behav Immun Volume: 125 Page(s): 240 - 248
03/01/2025 Authors: Bekhbat M; Li Z; Dunlop BW; Treadway MT; Mehta ND; Revill KP; Lucido MJ; Hong C; Ashchi A; Wommack EC
Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression.
Compr Psychoneuroendocrinol Volume: 21 Page(s): 100284
02/01/2025 Authors: Singh A; Bekhbat M; Goldsmith DR; Le N-A; Wommack EC; Li Z; Haroon E; Felger JC
Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis.
Psychiatry Res Volume: 341 Page(s): 116147
11/01/2024 Authors: Cohen S; Goldsmith DR; Ning CS; Addington J; Bearden CE; Cadenhead KS; Cannon TD; Cornblatt BA; Keshavan M; Mathalon DH
The psychoneuroimmunology of Psychosis: Peeking past the clouds of Heterogeneity: Editorial.
Brain Behav Immun Volume: 119 Page(s): 709 - 712
07/01/2024 Authors: Upthegrove R; Goldsmith DR
Immune and oxidative stress biomarkers in pediatric psychosis and psychosis-risk: Meta-analyses and systematic review.
Brain Behav Immun Volume: 117 Page(s): 1 - 11
03/01/2024 Authors: Taylor JH; Bermudez-Gomez J; Zhou M; Gmez O; Ganz-Leary C; Palacios-Ordonez C; Huque ZM; Barzilay R; Goldsmith DR; Gur RE
Predictors of successful anti-inflammatory drug trials in patients with schizophrenia: A meta-regression and critical commentary.
Brain Behav Immun Volume: 114 Page(s): 154 - 162
11/01/2023 Authors: Chandra A; Miller BJ; Goldsmith DR
The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases.
Brain Behav Immun Volume: 112 Page(s): 175 - 187
08/01/2023 Authors: Teng P; Li Y; Ku L; Wang F; Goldsmith DR; Wen Z; Yao B; Feng Y
Antipsychotics and Medical Comorbidity: A Retrospective Study in an Urban Outpatient Psychiatry Clinic.
Community Ment Health J Volume: 59 Page(s): 641 - 653
05/01/2023 Authors: Bennett CW; Gensler L; Goldsmith DR
Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology.
Biol Psychiatry Volume: 93 Page(s): 405 - 418
03/01/2023 Authors: Goldsmith DR; Bekhbat M; Mehta ND; Felger JC
Schizophrenia: A scientific graveyard or a pragmatically useful diagnostic construct?
Schizophr Res Volume: 242 Page(s): 141 - 143
04/01/2022 Authors: Walker EF; Goldsmith DR
A Comparison of Attitudes, Comfort, and Knowledge of Clozapine Among Two Diverse Samples of US Psychiatrists.
Community Ment Health J Volume: 58 Page(s): 517 - 525
04/01/2022 Authors: Cotes RO; Janjua AU; Broussard B; Lazris D; Khan A; Jiao Y; Kopelovich SL; Goldsmith DR
A Slow, Cautious, and Successful Clozapine Rechallenge After Myocarditis.
Prim Care Companion CNS Disord Volume: 24
03/10/2022 Authors: Bowers P; Rosenkrantz B; Palanci J; Goldsmith D; Cotes R
Four cases of myocarditis in US hospitals possibly associated with clozapine poor metabolism and a comparison with prior published cases.
Neuropsychopharmacol Hung Volume: 24 Page(s): 29 - 41
03/01/2022 Authors: Koenig M; McCollum B; Spivey JK; Coleman JK; Shelton C; Cotes RO; Goldsmith DR; De Leon J
The Tortoise Beats the Hare: The Case for Slow Clozapine Titrations with Serial CRP Monitoring.
Psychiatr Danub Volume: 34 Page(s): 428 - 429
01/01/2022 Authors: Cotes RO; Goldsmith DR
Brick by Brick: Building a Transdiagnostic Understanding of Inflammation in Psychiatry.
Harv Rev Psychiatry Volume: 30 Page(s): 40 - 53
01/01/2022 Authors: Thylur DS; Goldsmith DR
Effect of Inflammatory Markers on Acoustic Startle in the North American Prodrome Longitudinal Study (NAPLS-2) Cohort
Volume: 46 Page(s): 365 - 366
12/01/2021 Authors: Duncan E; Massa N; Goldsmith D; Adding-Ton J; Bachman PM; Bearden CE; Belger A; Cannon TD; Carrion RE; Cornblatt BA
C-Reactive Protein is Associated With Symptoms of Amotivation and Impaired Effort Allocation on the EEFRT Task in Patients With Schizophrenia
Volume: 46 Page(s): 340 - 341
12/01/2021 Authors: Goldsmith D; Ning C; Gross R; Walker E; Treadway M; Miller A
Transcriptomic signatures of psychomotor slowing in peripheral blood of depressed patients: evidence for immunometabolic reprogramming.
Mol Psychiatry Volume: 26 Page(s): 7384 - 7392
12/01/2021 Authors: Bekhbat M; Goldsmith DR; Woolwine BJ; Haroon E; Miller AH; Felger JC
The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia.
NPJ Schizophr Volume: 7 Page(s): 50
10/20/2021 Authors: Goldsmith DR; Massa N; Miller BJ; Miller AH; Duncan E
Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications.
Pharmacol Rev Volume: 73 Page(s): 1084 - 1117
07/01/2021 Authors: Lucido MJ; Bekhbat M; Goldsmith DR; Treadway MT; Haroon E; Felger JC; Miller AH
High Inflammation and Metabolic Dysfunction are Associated With Slowed Startle Response Latency in Patients With Schizophrenia
Volume: 89 Page(s): S284 - S285
05/01/2021 Authors: Goldsmith D; Massa N; Miller B; Cuthbert B; Miller A; Pearce B; Duncan E
Transcriptomic Signatures of Inflammation and Metabolic Reprogramming in Peripheral Blood Immune Cells are Implicated in Psychomotor Retardation in Depression
Volume: 89 Page(s): S377 - S378
05/01/2021 Authors: Bekhbat M; Goldsmith DR; Woolwine BJ; Haroon E; Miller AH; Felger JC
Clinical and Structural Differences in Delusions Across Diagnoses: A Systematic Review.
Front Integr Neurosci Volume: 15 Page(s): 726321
01/01/2021 Authors: Rootes-Murdy K; Goldsmith DR; Turner JA
Cluster Analysis of Clozapine Consumer Perspectives and Comparison to Consumers on Other Antipsychotics.
Schizophr Bull Open Volume: 2 Page(s): sgab043
01/01/2021 Authors: Sharma S; Kopelovich SL; Janjua AU; Pritchett C; Broussard B; Dhir M; Wilson JG; Goldsmith DR; Cotes RO
Tardive Dyskinesia: Spotlight on Current Approaches to Treatment.
Focus (Am Psychiatr Publ) Volume: 19 Page(s): 14 - 23
01/01/2021 Authors: Debrey SM; Goldsmith DR
Integrating Diversity, Equity, and Inclusion Into an Academic Department of Psychiatry and Behavioral Sciences.
Focus (Am Psychiatr Publ) Volume: 19 Page(s): 61 - 65
01/01/2021 Authors: Kaslow NJ; Schwartz AC; Ayna DK; Fani N; Gard B; Goldsmith DR; Hampton-Anderson J; Holton J; Marshall-Lee ED; White D
Prenatal exposure to viral infection and neuropsychiatric disorders in offspring: A review of the literature and recommendations for the COVID-19 pandemic.
Brain Behav Immun Volume: 91 Page(s): 756 - 770
01/01/2021 Authors: Zimmer A; Youngblood A; Adnane A; Miller BJ; Goldsmith DR
Systematic Review and Meta-Analysis of NMDA Receptor Autoantibodies in Psychotic Disorders
Volume: 45 Page(s): 247 - 247
12/01/2020 Authors: Thylur D; Miller B; Ellis J; Duncan E; Goldsmith D
High Inflammation and Metabolic Dysfunction are Associated With Increased Negative Symptoms in Patients With Schizophrenia
Volume: 45 Page(s): 342 - 343
12/01/2020 Authors: Goldsmith D; Massa N; Miller B; Pearce B; Miller A; Duncan E
Evaluating the Hypothesis That Schizophrenia Is an Inflammatory Disorder.
Focus (Am Psychiatr Publ) Volume: 18 Page(s): 391 - 401
10/01/2020 Authors: Miller BJ; Goldsmith DR
Where there's smoke, there's fire: Cannabis, P2RX7 and inflammatory pathways intersect to increase psychosis susceptibility.
Brain Behav Immun Volume: 89 Page(s): 3 - 4
10/01/2020 Authors: Goldsmith DR
Protein and gene markers of metabolic dysfunction and inflammation together associate with functional connectivity in reward and motor circuits in depression.
Brain Behav Immun Volume: 88 Page(s): 193 - 202
08/01/2020 Authors: Goldsmith DR; Bekhbat M; Le N-A; Chen X; Woolwine BJ; Li Z; Haroon E; Felger JC
Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia.
Brain Behav Immun Volume: 88 Page(s): 161 - 165
08/01/2020 Authors: Bekhbat M; Treadway MT; Goldsmith DR; Woolwine BJ; Haroon E; Miller AH; Felger JC
GENE SIGNATURES RELATED TO INSULIN SIGNALING AND TYROSINE METABOLISM DEFINE A SUB-TYPE OF DEPRESSION WITH ANHEDONIA AND HIGH CRP
Volume: 82 Page(s): A197 - A197
07/01/2020 Authors: Bekhbat M; Goldsmith DR; Treadway MT; Woolwine BJ; Haroon E; Miller AH; Felger JC
Integration of Clozapine-associated Harm Obsessions into Cognitive Behavioral Conceptualization and Treatment Planning for Thought Broadcasting: A Case Study.
J Psychiatr Pract Volume: 26 Page(s): 329 - 336
07/01/2020 Authors: Kopelovich SL; Wood K; Cotes RO; Goldsmith DR
What does plasma CRP tell us about peripheral and central inflammation in depression?
Mol Psychiatry Volume: 25 Page(s): 1301 - 1311
06/01/2020 Authors: Felger JC; Haroon E; Patel TA; Goldsmith DR; Wommack EC; Woolwine BJ; Le N-A; Feinberg R; Tansey MG; Miller AH
Toxoplasma Gondii Effects on the Relationship of Kynurenine Pathway Metabolites to Acoustic Startle Latency in Schizophrenia Versus Control Subjects
Volume: 87 Page(s): S236 - S236
05/01/2020 Authors: Duncan E; Massa N; Goldsmith DR; Gandhi ZH; Hankus A; Alrohaibani A; Goel N; Cuthbert B; Fargotstein M; Barr DB
Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression.
Neuropsychopharmacology Volume: 45 Page(s): 998 - 1007
05/01/2020 Authors: Haroon E; Welle JR; Woolwine BJ; Goldsmith DR; Baer W; Patel T; Felger JC; Miller AH
Inflammatory markers are associated with psychomotor slowing in patients with schizophrenia compared to healthy controls.
NPJ Schizophr Volume: 6 Page(s): 8
04/01/2020 Authors: Goldsmith DR; Massa N; Pearce BD; Wommack EC; Alrohaibani A; Goel N; Cuthbert B; Fargotstein M; Felger JC; Haroon E
Reply to the Letter to the Editor: Reduced neuropsychiatric events as "beneficial reactions" to drugs: Seek associations with caution.
Brain Behav Immun Volume: 84 Page(s): 277
02/01/2020 Authors: Essali N; Goldsmith DR; Carbone L; Miller BJ
Selective Review of Neuroimaging Findings in Youth at Clinical High Risk for Psychosis: On the Path to Biomarkers for Conversion.
Front Psychiatry Volume: 11 Page(s): 567534
01/01/2020 Authors: Ellis JK; Walker EF; Goldsmith DR
Inflammation and Negative Symptoms of Schizophrenia: Implications for Reward Processing and Motivational Deficits.
Front Psychiatry Volume: 11 Page(s): 46
01/01/2020 Authors: Goldsmith DR; Rapaport MH
Toxoplasma gondii Effects on the Relationship of Kynurenine Pathway Metabolites to Acoustic Startle Latency in Schizophrenia vs. Control Subjects.
Front Psychiatry Volume: 11 Page(s): 552743
01/01/2020 Authors: Pearce BD; Massa N; Goldsmith DR; Gandhi ZH; Hankus A; Alrohaibani A; Goel N; Cuthbert B; Fargotstein M; Barr DB
Severity of Psychomotor Retardation in Depression is Associated With mRNA Enrichment of Inflammatory and Metabolic Signaling Pathways
Volume: 44 Page(s): 438 - 439
12/01/2019 Authors: Goldsmith D; Bekhbat M; Woolwine B; Haroon E; Miller A; Felger J
Psychosis as an adverse effect of monoclonal antibody immunotherapy.
Brain Behav Immun Volume: 81 Page(s): 646 - 649
10/01/2019 Authors: Essali N; Goldsmith DR; Carbone L; Miller BJ
Severity of psychomotor retardation in depressed patients is associated with mRNA enrichment of toll-like receptor, cytokine and mTOR signaling pathways
Volume: 81 Page(s): 29 - 29
10/01/2019 Authors: Bekhbat M; Goldsmith DR; Miller AH; Felger JC
Relationships Between Inflammatory Markers and Kynurenine Metabolites in Patients With Schizophrenia but Not Healthy Controls
Volume: 85 Page(s): S365 - S365
05/15/2019 Authors: Goldsmith D; Massa N; Pearce B; Wommack E; Alrohaibani A; Goel N; Cuthbert B; Fargotstein M; Barr DB; Panuwet P
Association of baseline inflammatory markers and the development of negative symptoms in individuals at clinical high risk for psychosis.
Brain Behav Immun Volume: 76 Page(s): 268 - 274
02/01/2019 Authors: Goldsmith DR; Haroon E; Miller AH; Addington J; Bearden C; Cadenhead K; Cannon T; Cornblatt B; Mathalon D; McGlashan T
Mask Off? Lithium Augmentation for Clozapine Rechallenge After Neutropenia or Agranulocytosis: Discontinuation Might Be Risky.
Prim Care Companion CNS Disord Volume: 20
11/29/2018 Authors: Boazak M; Goldsmith DR; Cotes RO
Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder.
Psychoneuroendocrinology Volume: 95 Page(s): 43 - 49
09/01/2018 Authors: Haroon E; Daguanno AW; Woolwine BJ; Goldsmith DR; Baer WM; Wommack EC; Felger JC; Miller AH
TNF- and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia.
Schizophr Res Volume: 199 Page(s): 281 - 284
09/01/2018 Authors: Goldsmith DR; Haroon E; Miller AH; Strauss GP; Buckley PF; Miller BJ
Characteristics of Medicaid Recipients Receiving Persistent Antipsychotic Polypharmacy.
Community Ment Health J Volume: 54 Page(s): 699 - 706
08/01/2018 Authors: Cotes RO; Goldsmith DR; Kopelovich SL; Lally CA; Druss BG
Re-titration rates after clozapine-induced neutropenia or agranulocytosis: A case report and literature review.
Clin Schizophr Relat Psychoses
06/26/2018 Authors: Boazak M; Kahn B; Cox L; Ragazino J; Goldsmith DR; Cotes RO
Association of Baseline Tumor Necrosis Factor and the Development of Negative Symptoms in Individuals at Clinical High Risk for Psychosis
Volume: 83 Page(s): S330 - S331
05/01/2018 Authors: Goldsmith D; Miller A; Addington J; Bearden C; Cadenhead K; Cannon T; Cornblatt B; Mathalon D; McGlashan T; Perkins D
An Update on Promising Biomarkers in Schizophrenia.
Focus (Am Psychiatr Publ) Volume: 16 Page(s): 153 - 163
04/01/2018 Authors: Goldsmith DR; Crooks CL; Walker EF; Cotes RO
An Unmet Need: A Clozapine-Induced Myocarditis Screening Protocol.
Prim Care Companion CNS Disord Volume: 19
08/03/2017 Authors: Goldsmith DR; Cotes RO
ASSOCIATION BETWEEN INFLAMMATORY MARKERS AND NEGATIVE SYMPTOMS IN INDIVIDUALS WITH PERSISTENT SYMPTOMS OF SCHIZOPHRENIA TREATED WITH CLOZAPINE
SCHIZOPHRENIA BULLETIN Volume: 43 Page(s): S184 - S184
03/01/2017 Authors: Goldsmith D; Kopelovich S; Novacek D; Widener J; Wommack E; Felger J; Miller A; Cotes R
Suicide Prevention in Schizophrenia: Do Long-Acting Injectable Antipsychotics (LAIs) have a Role?
CNS Neurol Disord Drug Targets Volume: 16 Page(s): 454 - 462
01/01/2017 Authors: Pompili M; Orsolini L; Lamis DA; Goldsmith DR; Nardella A; Falcone G; Corigliano V; Luciano M; Fiorillo A
Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions.
Neuropsychopharmacology Volume: 42 Page(s): 299 - 317
01/01/2017 Authors: Miller BJ; Goldsmith DR
Association Between Inflammatory Markers and Negative Symptoms in Individuals With Persistent Symptoms of Schizophrenia Treated With Clozapine
NEUROPSYCHOPHARMACOLOGY Volume: 41 Page(s): S390 - S391
12/01/2016 Authors: Goldsmith D; Kopelovich S; Novacek D; Widener J; Wommack E; Felger J; Miller A; Cotes R
A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression.
Mol Psychiatry Volume: 21 Page(s): 1696 - 1709
12/01/2016 Authors: Goldsmith DR; Rapaport MH; Miller BJ
Parental type 2 diabetes in patients with non-affective psychosis.
Schizophr Res Volume: 175 Page(s): 223 - 225
08/01/2016 Authors: Miller BJ; Goldsmith DR; Paletta N; Wong J; Kandhal P; Black C; Rapaport MH; Buckley PF
Inflammatory markers are associated with decreased psychomotor speed in patients with major depressive disorder.
Brain Behav Immun Volume: 56 Page(s): 281 - 288
08/01/2016 Authors: Goldsmith DR; Haroon E; Woolwine BJ; Jung MY; Wommack EC; Harvey PD; Treadway MT; Felger JC; Miller AH
Inflammatory Markers are Associated with Decreased Psychomotor Speed in Patients with Major Depressive Disorder
Volume: 79 Page(s): 53S - 53S
05/01/2016 Authors: Goldsmith DR; Haroon E; Woolwine BJ; Jung MY; Wommack E; Harvey PD; Treadway MT; Felger JC; Miller AH
Inflammatory Cytokines Are Associated with Decreased Psychomotor Speed in Female, but Not Male, Patients with Major Depression
Volume: 40 Page(s): S339 - S340
12/01/2015 Authors: Goldsmith D; Haroon E; Woolwine B; Jung M; Wommack E; Felger J; Miller A
META-ANALYSIS OF CYTOKINE ALTERATIONS IN ACUTELY ILL PSYCHIATRIC PATIENTS: COMPARISONS BETWEEN SCHIZOPHRENIA, BIPOLAR DISORDER, AND DEPRESSION
Volume: 41 Page(s): S140 - S140
03/01/2015 Authors: Goldsmith DR; Miller BJ; Rapaport MH
Neural Correlates of Social Cooperation and Non-Cooperation as a Function of Psychopathy (vol 61, pg 1260, 2007)
BIOLOGICAL PSYCHIATRY Volume: 67 Page(s): 595 - 595
03/15/2010 Authors: Rilling JK; Glenn AL; Jairam MR; Pagnoni G; Goldsmith DR; Elfenbein HA; Lilienfeld SO
Social cognitive neural networks during in-group and out-group interactions.
Neuroimage Volume: 41 Page(s): 1447 - 1461
07/15/2008 Authors: Rilling JK; Dagenais JE; Goldsmith DR; Glenn AL; Pagnoni G
The neural correlates of the affective response to unreciprocated cooperation.
Neuropsychologia Volume: 46 Page(s): 1256 - 1266
04/01/2008 Authors: Rilling JK; Goldsmith DR; Glenn AL; Jairam MR; Elfenbein HA; Dagenais JE; Murdock CD; Pagnoni G
Neural correlates of social cooperation and non-cooperation as a function of psychopathy.
Biol Psychiatry Volume: 61 Page(s): 1260 - 1271
06/01/2007 Authors: Rilling JK; Glenn AL; Jairam MR; Pagnoni G; Goldsmith DR; Elfenbein HA; Lilienfeld SO

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