Publications

• Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk.
  Nat Commun Volume: 15 Page(s): 10201
  11/25/2024 Authors: Oshinowo O; Copeland R; Patel A; Shaver N; Fay ME; Jeltuhin R; Xiang Y; Caruso C; Otumala AE; Hernandez S
• Less-deformable erythrocyte subpopulations biomechanically induce endothelial inflammation in sickle cell disease.
  Blood Volume: 144 Page(s): 2050 - 2062
  11/07/2024 Authors: Caruso C; Cheng X; Michaud ME; Szafraniec HM; Thomas BE; Fay ME; Mannino RG; Zhang X; Sakurai Y; Li W
• Iquitos Virus in Traveler Returning to the United States from Ecuador.
  Emerg Infect Dis Volume: 30 Page(s): 2447 - 2451
  11/01/2024 Authors: Baer K; Arora I; Kimbro J; Haider A; Mott M; Marshall K; Wu HM; Fairley J; Piantadosi A; Myers DR
• Single-pericyte nanomechanics measured by contraction cytometry.
  APL Bioeng Volume: 8 Page(s): 036109
  09/01/2024 Authors: Islam MM; Gaska I; Oshinowo O; Otumala A; Shekhar S; Au Yong N; Myers DR
• An economical in-class sticker microfluidic activity develops student expertise in microscale physics and device manufacturing.
  Lab Chip Volume: 24 Page(s): 2176 - 2192
  04/16/2024 Authors: Delgado P; Luna CA; Dissanayaka A; Oshinowo O; Waggoner JJ; Schley S; Fernandez T; Myers DR
• Opportunities and considerations for studying liver disease with microphysiological systems on a chip.
  Lab Chip Volume: 23 Page(s): 2877 - 2898
  06/28/2023 Authors: Otumala AE; Hellen DJ; Luna CA; Delgado P; Dissanayaka A; Ugwumadu C; Oshinowo O; Islam MM; Shen L; Karpen SJ
• Universal pre-mixing dry-film stickers capable of retrofitting existing microfluidics.
  Biomicrofluidics Volume: 17 Page(s): 014104
  01/01/2023 Authors: Delgado P; Oshinowo O; Fay ME; Luna CA; Dissanayaka A; Dorbala P; Ravindran A; Shen L; Myers DR
• Simple and Economical Extraction of Viral RNA and Storage at Ambient Temperature.
  Microbiol Spectr Volume: 10 Page(s): e0085922
  06/29/2022 Authors: Hernandez S; Cardozo F; Myers DR; Rojas A; Waggoner JJ
• INTRODUCING A BIOPHYSICAL PLATELET FUNCTION PANEL TO INVESTIGATE BLEEDING OF UNKNOWN CAUSE
  Volume: 69
  06/01/2022 Authors: Azer S; Oshinowo O; Fay M; Sakurai Y; Qiu Y; Bennett C; Meeks S; Brown M; Myers D; Lam W
• Resolving the missing link between single platelet force and clot contractile force.
  iScience Volume: 25 Page(s): 103690
  01/21/2022 Authors: Sun Y; Oshinowo O; Myers DR; Lam WA; Alexeev A
• Pathologically stiff erythrocytes impede contraction of blood clots: Reply to comment.
  J Thromb Haemost Volume: 19 Page(s): 2894 - 2895
  11/01/2021 Authors: Tutwiler V; Litvinov RI; Protopopova A; Nagaswami C; Villa C; Woods E; Abdulmalik O; Siegel DL; Russell JE; Muzykantov VR
• Pathologically stiff erythrocytes impede contraction of blood clots.
  J Thromb Haemost Volume: 19 Page(s): 1990 - 2001
  08/01/2021 Authors: Tutwiler V; Litvinov RI; Protopopova A; Nagaswami C; Villa C; Woods E; Abdulmalik O; Siegel DL; Russell JE; Muzykantov VR
• Vascularized Microfluidics and Their Untapped Potential for Discovery in Diseases of the Microvasculature.
  Annu Rev Biomed Eng Volume: 23 Page(s): 407 - 432
  07/13/2021 Authors: Myers DR; Lam WA
• Platelet heterogeneity enhances blood clot volumetric contraction: An example of asynchrono-mechanical amplification.
  Biomaterials Volume: 274 Page(s): 120828
  07/01/2021 Authors: Sun Y; Myers DR; Nikolov SV; Oshinowo O; Baek J; Bowie SM; Lambert TP; Woods E; Sakurai Y; Lam WA
• Stiffness based enrichment of leukemia cells using microfluidics.
  APL Bioeng Volume: 4 Page(s): 036101
  09/01/2020 Authors: Islam M; Raj A; McFarland B; Brink HM; Ciciliano J; Fay M; Myers DR; Flowers C; Waller EK; Lam W
• Getting a good view: in vitro imaging of platelets under flow.
  Platelets Volume: 31 Page(s): 570 - 579
  07/03/2020 Authors: Oshinowo O; Lambert T; Sakurai Y; Copeland R; Hansen CE; Lam WA; Myers DR
• Label-free hematology analysis using deep-ultraviolet microscopy.
  Proc Natl Acad Sci U S A Volume: 117 Page(s): 14779 - 14789
  06/30/2020 Authors: Ojaghi A; Carrazana G; Caruso C; Abbas A; Myers DR; Lam WA; Robles FE
• Increased Platelet Force Is Associated with Decreased Bleeding Severity in Pediatric Immune Thrombocytopenia
  Volume: 134
  11/13/2019 Authors: Oshinowo OT; Copeland R; Caruso C; Fay ME; Leong T; Bennett CM; Lam WA; Myers DR
• The biophysics and mechanics of blood from a materials perspective.
  Nat Rev Mater Volume: 4 Page(s): 294 - 311
  05/01/2019 Authors: Qiu Y; Myers DR; Lam WA
• Feeling the Force: Measurements of Platelet Contraction and Their Diagnostic Implications.
  Semin Thromb Hemost Volume: 45 Page(s): 285 - 296
  04/01/2019 Authors: Williams EK; Oshinowo O; Ravindran A; Lam WA; Myers DR
• Smartphone app for non-invasive detection of anemia using only patient-sourced photos.
  Nat Commun Volume: 9 Page(s): 4924
  12/04/2018 Authors: Mannino RG; Myers DR; Tyburski EA; Caruso C; Boudreaux J; Leong T; Clifford GD; Lam WA
• A Comparative Medicine Study of Platelet Biophysics Among Hemostasis Models of Different Species
  Volume: 132
  11/29/2018 Authors: Copeland R; Oshinowo OT; Sakurai Y; Fay ME; Petrich BG; Brainard B; Lam WA; Myers DR
• A microengineered vascularized bleeding model that integrates the principal components of hemostasis.
  Nat Commun Volume: 9 Page(s): 509
  02/06/2018 Authors: Sakurai Y; Hardy ET; Ahn B; Tran R; Fay ME; Ciciliano JC; Mannino RG; Myers DR; Qiu Y; Carden MA
• Platelet Contraction Cytometry: A Biophysical, High-Throughput Research-Enabling and Diagnostic Platform
  Volume: 130
  12/07/2017 Authors: Oshinowo OT; Lam AW; Brainard B; Bennett CM; Lam WA; Myers DR
• Clot Formation Under Physiological Flow Conditions Is Altered in Sickle Cell Disease As Measured By a Multiparameter Microfluidic System
  Volume: 130
  12/07/2017 Authors: Ravindran A; Baek J; Myers DR; Lam WA
• Towards remote assessment and screening of acute abdominal pain using only a smartphone with native accelerometers.
  Sci Rep Volume: 7 Page(s): 12750
  10/06/2017 Authors: Myers DR; Weiss A; Rollins MR; Lam WA
• Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency.
  Mol Ther Volume: 25 Page(s): 2372 - 2382
  10/04/2017 Authors: Tran R; Myers DR; Denning G; Shields JE; Lytle AM; Alrowais H; Qiu Y; Sakurai Y; Li WC; Brand O
• Platelet-Microcapsule Hybrids Leverage Contractile Force for Targeted Delivery of Hemostatic Agents.
  ACS Nano Volume: 11 Page(s): 5579 - 5589
  06/27/2017 Authors: Hansen CE; Myers DR; Baldwin WH; Sakurai Y; Meeks SL; Lyon LA; Lam WA
• Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions.
  Nat Commun Volume: 8 Page(s): 15594
  06/08/2017 Authors: Qiu Y; Tong S; Zhang L; Sakurai Y; Myers DR; Hong L; Lam WA; Bao G
• Single-platelet nanomechanics measured by high-throughput cytometry.
  Nat Mater Volume: 16 Page(s): 230 - 235
  02/01/2017 Authors: Myers DR; Qiu Y; Fay ME; Tennenbaum M; Chester D; Cuadrado J; Sakurai Y; Baek J; Tran R; Ciciliano JC
• Leveraging the Contractile Force of Platelets for Targeted Factor VIII Delivery in Hemophilia with Inhibitors
  Volume: 128
  12/02/2016 Authors: Hansen CE; Myers DR; Sakurai Y; Baldwin WH; Meeks SL; Lyon LA; Lam WA
• Cellular softening mediates leukocyte demargination and trafficking, thereby increasing clinical blood counts.
  Proc Natl Acad Sci U S A Volume: 113 Page(s): 1987 - 1992
  02/23/2016 Authors: Fay ME; Myers DR; Kumar A; Turbyfield CT; Byler R; Crawford K; Mannino RG; Laohapant A; Tyburski EA; Sakurai Y
• Colorectal delivery and retention of PEG-Amprenavir-Bac7 nanoconjugates--proof of concept for HIV mucosal pre-exposure prophylaxis.
  Drug Deliv Transl Res Volume: 6 Page(s): 1 - 16
  02/01/2016 Authors: Samizadeh M; Zhang X; Gunaseelan S; Nelson AG; Palombo MS; Myers DR; Singh Y; Ganapathi U; Szekely Z; Sinko PJ
• Improving Lentiviral Transduction Efficiency with Microfluidic Systems
  Volume: 126
  12/03/2015 Authors: Tran R; Myers DR; Shields JE; Ahn B; Qiu Y; Hansen C; Sakurai Y; Moot R; Spencer HT; Doering CB
• Vessel Geometry Interacts with Red Blood Cell Stiffness to Promote Endothelial Dysfunction in Sickle Cell Disease
  Volume: 126
  12/03/2015 Authors: Wang Y; Mannino RG; Myers DR; Li W; Joiner CH; Lam WA
• Clot Contraction-Mediated Erythrocyte Packing Is Significantly Altered in Sickle Cell Disease
  Volume: 126
  12/03/2015 Authors: Strauss H; Myers DR; Rollins MR; Weisel JW; Lam WA
• Platelets and physics: How platelets "feel" and respond to their mechanical microenvironment.
  Blood Rev Volume: 29 Page(s): 377 - 386
  11/01/2015 Authors: Qiu Y; Ciciliano J; Myers DR; Tran R; Lam WA
• Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach.
  Blood Volume: 126 Page(s): 817 - 824
  08/06/2015 Authors: Ciciliano JC; Sakurai Y; Myers DR; Fay ME; Hechler B; Meeks S; Li R; Dixon JB; Lyon LA; Gachet C
• Platelet geometry sensing spatially regulates -granule secretion to enable matrix self-deposition.
  Blood Volume: 126 Page(s): 531 - 538
  07/23/2015 Authors: Sakurai Y; Fitch-Tewfik JL; Qiu Y; Ahn B; Myers DR; Tran R; Fay ME; Ding L; Spearman PW; Michelson AD
• "Do-it-yourself in vitro vasculature that recapitulates in vivo geometries for investigating endothelial-blood cell interactions".
  Sci Rep Volume: 5 Page(s): 12401
  07/23/2015 Authors: Mannino RG; Myers DR; Ahn B; Wang Y; Margo Rollins; Gole H; Lin AS; Guldberg RE; Giddens DP; Timmins LH
• Platelet mechanosensing of collagen matrices.
  PLoS One Volume: 10 Page(s): e0126624
  01/01/2015 Authors: Kee MF; Myers DR; Sakurai Y; Lam WA; Qiu Y
• Platelet Adhesion, Spreading and Activation Are Mediated By Mechanosensing of Matrix Stiffness
  Volume: 124
  12/06/2014 Authors: Qiu Y; Brown AC; Myers DR; Sakurai Y; Mannino R; Tran R; Ahn B; Hardy E; Kee MF; Kumar S
• Platelet Mechanosensing of Collagen Matrices
  Volume: 124
  12/06/2014 Authors: Kee MF; Qiu Y; Myers DR; Sakurai Y; Lam WA
• "Self-Deposition" of Matrix Proteins from Platelet alpha-Granules Enable Extended Adhesion and Spreading on Micron/Submicron-Scale Fibrinogen and Collagen Substrates.
  Volume: 124
  12/06/2014 Authors: Sakurai Y; Fitch-Tewfik JL; Qiu Y; Myers DR; Ahn B; Flaumenhaft R; Lam WA
• Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation.
  Proc Natl Acad Sci U S A Volume: 111 Page(s): 14430 - 14435
  10/07/2014 Authors: Qiu Y; Brown AC; Myers DR; Sakurai Y; Mannino RG; Tran R; Ahn B; Hardy ET; Kee MF; Kumar S
• Simplified prototyping of perfusable polystyrene microfluidics.
  Biomicrofluidics Volume: 8 Page(s): 046501
  07/01/2014 Authors: Tran R; Ahn B; Myers DR; Qiu Y; Sakurai Y; Moot R; Mihevc E; Trent Spencer H; Doering C; A Lam W
• New Insights Into The Mechanisms Of Ferric Chloride-Induced Thrombosis: a Reductionist Microfluidic Approach
  Volume: 122
  11/15/2013 Authors: Ciciliano JC; Myers DR; Fay ME; Sakurai Y; Li R; Lyon A; Lam WA
• Mitochondrially mediated integrin IIb3 protein inactivation limits thrombus growth.
  J Biol Chem Volume: 288 Page(s): 30672 - 30681
  10/18/2013 Authors: Liu F; Gamez G; Myers DR; Clemmons W; Lam WA; Jobe SM
• Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.
  Blood Volume: 122 Page(s): 1695 - 1706
  09/05/2013 Authors: Chen Y; Aardema J; Kale S; Whichard ZL; Awomolo A; Blanchard E; Chang B; Myers DR; Ju L; Tran R
• Biomechanics of haemostasis and thrombosis in health and disease: from the macro- to molecular scale.
  J Cell Mol Med Volume: 17 Page(s): 579 - 596
  05/01/2013 Authors: Tran R; Myers DR; Ciciliano J; Trybus Hardy EL; Sakurai Y; Ahn B; Qiu Y; Mannino RG; Fay ME; Lam WA
• An "Endothelialized" Microfluidic System That Distinguishes Procoagulant Mechanisms in Arterial and Venous Thrombosis
  Volume: 120
  11/16/2012 Authors: Ahn B; Sakurai Y; Myers DR; Qiu Y; Hardy E; Tran R; Mannino R; Wolberg AS; Lam W
• Endothelialized microfluidics for studying microvascular interactions in hematologic diseases.
  J Vis Exp
  06/22/2012 Authors: Myers DR; Sakurai Y; Tran R; Ahn B; Hardy ET; Mannino R; Kita A; Tsai M; Lam WA
• Measuring the Direct Effects of Sickle Cell Vaso-Occlusion on Endothelial Cells Using Microfluidic Technology
  Volume: 118 Page(s): 410 - 410
  11/18/2011 Authors: Myers DR; Sakurai Y; Chappa P; Barabino G; Archer DR; Lam W
• A Novel Assay That Integrates the Effects of Multiple Agonists At the Single-Platelet Level
  Volume: 118 Page(s): 1402 - 1403
  11/18/2011 Authors: Sakurai Y; Myers DR; Kita A; Lam W
• Nanomechanics of Platelet Contractility
  Volume: 118 Page(s): 959 - 960
  11/18/2011 Authors: Myers DR; Sulchek T; Lam W
• Mitochondrially-Mediated Platelet Integrin Alpha(IIb)beta(3) Inactivation Limits Platelet Recruitment and Thrombus Growth
  Volume: 118 Page(s): 1400 - 1400
  11/18/2011 Authors: Liu F; Gamez G; Myers DR; Lam W; Jobe SM
• Platelet Sensing of Microenviornmental Geometry Guides Adhesion and Spreading: A Quantitative Study At the Single-Cell Level
  Volume: 118 Page(s): 956 - 957
  11/18/2011 Authors: Kita A; Sakurai Y; Myers DR; Rounsevell R; Seok TJ; Yu K; Huang J; Wu M; Fletcher D; Lam W
• Microenvironmental geometry guides platelet adhesion and spreading: a quantitative analysis at the single cell level.
  PLoS One Volume: 6 Page(s): e26437
  01/01/2011 Authors: Kita A; Sakurai Y; Myers DR; Rounsevell R; Huang JN; Seok TJ; Yu K; Wu MC; Fletcher DA; Lam WA
• Silicon carbide coated MEMS strain sensor for harsh environment applications
  Page(s): 826 - +
  01/01/2007 Authors: Azevedo RG; Zhang J; Jones DG; Myers DR; Jog AV; Jamshidi B; Wijesundara MBJ; Maboudian R; Pisano AP